sparteine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2467 90-39-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sparteine
  • lupinidin
  • lupinidine
  • (-)-Sparteine
  • spartein
  • l-Sparteine
  • sparteine sulfate
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
  • Molecular weight: 234.39
  • Formula: C15H26N2
  • CLOGP: 1.77
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -2.40
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.20 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.435 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.117 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.612 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 3.251 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 65.840 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 28.010 % High 1
herg hERG pIC50 3.976 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.908 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.767 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 43.020 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IRAK4,ITK,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,TEK,TGFBR1 29
kinase-selectivity-class AXL,CAMK2D,CDK4,EIF2AK3,PLK1,TYRO3 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.815 High 1
mh-clint Mouse hepatocyte intrinsic clearance 13.490 High 1
mppb Mouse plasma protein binding (% unbound) 74.870 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.687 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 82.820 % High 1
rh-clint Rat hepatocyte intrinsic clearance 5.236 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 43.700 % High 1
rppb Rat plasma protein binding (% unbound) 70.430 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 322.849 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BA04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents

Related Drugs by ATC class:

C01BA Antiarrhythmics, class Ia 7 drugs
ajmalinedisopyramidehydroquinidinelorajmineprajmaliumprocainamidequinidine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.96 Basic
pKa2 8.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01041 KEGG_DRUG
C0037760 UMLSCUI
CHEBI:28827 CHEBI
CHEMBL1908847 ChEMBL_ID
DB06727 DRUGBANK_ID
CHEMBL1908348 ChEMBL_ID
D013034 MESH_DESCRIPTOR_UI
644020 PUBCHEM_CID
1447 INN_ID
6160-12-9 SECONDARY_CAS_RN
298897D62S UNII
001311 NDDF
006191 NDDF
377002 SNOMEDCT_US
412311003 SNOMEDCT_US

Pharmaceutical products:

None