sparteine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2467 90-39-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sparteine
  • lupinidin
  • lupinidine
  • (-)-Sparteine
  • spartein
  • l-Sparteine
  • sparteine sulfate
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
  • Molecular weight: 234.39
  • Formula: C15H26N2
  • CLOGP: 2.60
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -2.40
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.20 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BA04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.96 Basic
pKa2 8.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01041 KEGG_DRUG
6160-12-9 SECONDARY_CAS_RN
C0037760 UMLSCUI
CHEBI:28827 CHEBI
3966 PUBCHEM_CID
DB06727 DRUGBANK_ID
CHEMBL412873 ChEMBL_ID
CHEMBL2303617 ChEMBL_ID
D013034 MESH_DESCRIPTOR_UI
1447 INN_ID
298897D62S UNII
001311 NDDF
006191 NDDF
377002 SNOMEDCT_US
412311003 SNOMEDCT_US

Pharmaceutical products:

None