sitosterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2451 83-46-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • angelicin
  • azuprostat
  • betaprost
  • prostasal
  • quebrachol
  • sitosterol
  • alpha-Dihydrofucosterol
  • beta-Sitosterin
  • beta-Sitosterol
  • SITOSTEROL, BETA-
used as tranquillizer; sedative; or anticonvulsant; structure
  • Molecular weight: 414.72
  • Formula: C29H50O
  • CLOGP: 10.45
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -7.35
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.02 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 372.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D007202 Indicators and Reagents
MeSH PA D007364 Intercalating Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:35821 anticholesteremic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] B Enzyme IC50 5.56 CHEMBL
Amine oxidase [flavin-containing] A Enzyme Ki 6.34 CHEMBL
Prothrombin Enzyme Ki 6.57 CHEMBL
Dipeptidyl peptidase 4 Enzyme IC50 4.54 CHEMBL
Nuclear factor NF-kappa-B p105 subunit Cytosolic other IC50 5.60 CHEMBL
DNA polymerase beta Enzyme IC50 4.58 CHEMBL
Acetylcholinesterase Enzyme IC50 4.59 CHEMBL
Amine oxidase [flavin-containing] A Enzyme IC50 5.05 CHEMBL

External reference:

IDSource
4021488 VUID
N0000148865 NUI
523-50-2 SECONDARY_CAS_RN
4021488 VANDF
C0037215 UMLSCUI
CHEBI:27693 CHEBI
CHEMBL2108117 ChEMBL_ID
CHEMBL53569 ChEMBL_ID
CHEMBL221542 ChEMBL_ID
DB14038 DRUGBANK_ID
C025473 MESH_SUPPLEMENTAL_RECORD_UI
C011659 MESH_SUPPLEMENTAL_RECORD_UI
222284 PUBCHEM_CID
47070 RXNORM
012937 NDDF
CZZ080D7BD UNII

Pharmaceutical products:

None