silymarin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2443 65666-07-1

Description:

MoleculeDescription

Synonyms:

  • silymarin
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A05BA03 ALIMENTARY TRACT AND METABOLISM
BILE AND LIVER THERAPY
LIVER THERAPY, LIPOTROPICS
Liver therapy
MeSH PA D000975 Antioxidants
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:62868 hepatoprotective agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 1 Enzyme Ki 5.83 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.60 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.19 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.05 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.39 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.34 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 5.01 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.33 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.99 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.04 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 5.32 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.93 CHEMBL
Urokinase-type plasminogen activator Enzyme IC50 4.68 CHEMBL
Prothrombin Enzyme Kd 4.73 CHEMBL
P-glycoprotein 3 Unclassified Kd 5.17 CHEMBL
Xanthine dehydrogenase/oxidase Enzyme IC50 4.10 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 6.19 CHEMBL

External reference:

IDSource
N0000167027 NUI
C0037135 UMLSCUI
NOCODE MMSL
9794 RXNORM
004366 NDDF
CHEMBL431701 ChEMBL_ID
CHEBI:9144 CHEBI
CHEMBL1401508 ChEMBL_ID
D012838 MESH_DESCRIPTOR_UI
31553 PUBCHEM_CID

Pharmaceutical products:

None