salicylamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 2415 65-45-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salicylamide
  • salicylic acid amide
  • 2-carbamoylphenol
  • 2-hydroxybenzamide
  • Molecular weight: 137.14
  • Formula: C7H7NO2
  • CLOGP: 1.28
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.24
  • ROTB: 1

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BA05 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA55 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA75 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35842 anti-rheumatic drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Joint pain indication 57676002
Backache indication 161891005
Headache disorder indication 230461009
Fever indication 386661006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypophosphatemia contraindication 4996001
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Gastrectomy contraindication 53442002
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hemorrhoids contraindication 70153002 DOID:9746
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Atrophic gastritis contraindication 84568007 DOID:8929
Epilepsy contraindication 84757009 DOID:1826
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Panic disorder contraindication 371631005 DOID:594
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.32 acidic
pKa2 12.39 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018828 VUID
N0000147131 NUI
D01811 KEGG_DRUG
4018828 VANDF
C0036071 UMLSCUI
CHEBI:32114 CHEBI
OHB PDB_CHEM_ID
CHEMBL27577 ChEMBL_ID
5147 PUBCHEM_CID
DB08797 DRUGBANK_ID
1861 INN_ID
C031060 MESH_SUPPLEMENTAL_RECORD_UI
C524082 MESH_SUPPLEMENTAL_RECORD_UI
EM8BM710ZC UNII
9518 RXNORM
5076 MMSL
5438 MMSL
d03094 MMSL
001589 NDDF
22192002 SNOMEDCT_US
400325002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pain Stoppers Regular HUMAN OTC DRUG LABEL 4 0498-2421 TABLET 152 mg ORAL OTC monograph not final 14 sections
Pain Stoppers HUMAN OTC DRUG LABEL 4 0498-2422 TABLET 152 mg ORAL OTC monograph not final 14 sections
Zee Pain Aid HUMAN OTC DRUG LABEL 3 35418-242 TABLET 152 mg ORAL OTC monograph not final 9 sections
Zee Pain Aid HUMAN OTC DRUG LABEL 3 42961-042 TABLET 152 mg ORAL OTC monograph not final 9 sections
Green Guard Pain and Ache Relief HUMAN OTC DRUG LABEL 4 47682-003 TABLET 152 mg ORAL OTC monograph not final 17 sections
Green Guard Pain and Ache Relief HUMAN OTC DRUG LABEL 4 47682-003 TABLET 152 mg ORAL OTC monograph not final 17 sections
Medi First Pain Relief HUMAN OTC DRUG LABEL 4 47682-811 TABLET 152 mg ORAL OTC monograph not final 16 sections
Medi First Pain Relief HUMAN OTC DRUG LABEL 4 47682-811 TABLET 152 mg ORAL OTC monograph not final 16 sections
Medi First Plus Pain Zapper HUMAN OTC DRUG LABEL 4 47682-911 TABLET 152 mg ORAL OTC monograph not final 16 sections
Medi First Plus Pain Zapper HUMAN OTC DRUG LABEL 4 47682-911 TABLET 152 mg ORAL OTC monograph not final 16 sections
Unishield Pain Zapper HUMAN OTC DRUG LABEL 4 49314-8113 TABLET 152 mg ORAL OTC monograph not final 17 sections
Unishield Pain Zapper HUMAN OTC DRUG LABEL 4 49314-8113 TABLET 152 mg ORAL OTC monograph not final 17 sections
EXAPRIN HUMAN OTC DRUG LABEL 4 50332-0105 TABLET 152 mg ORAL OTC monograph not final 14 sections
Pain Free HUMAN OTC DRUG LABEL 4 51532-0242 TABLET 152 1 ORAL OTC monograph not final 9 sections
PAIN RELIEVER HUMAN OTC DRUG LABEL 4 67060-113 TABLET 152 1 ORAL OTC monograph not final 9 sections
PAIN TERMINATOR HUMAN OTC DRUG LABEL 3 69103-2507 TABLET 152 mg ORAL OTC monograph not final 9 sections
Extra Strength Pain Reliever HUMAN OTC DRUG LABEL 4 71105-242 TABLET 152 mg ORAL OTC monograph not final 12 sections
Crane Safety XS Pain Relief HUMAN OTC DRUG LABEL 4 73408-911 TABLET 152 mg ORAL OTC monograph not final 17 sections
Crane Safety XS Pain Relief HUMAN OTC DRUG LABEL 4 73408-911 TABLET 152 mg ORAL OTC monograph not final 17 sections
Aramark Pain Free HUMAN OTC DRUG LABEL 4 81238-0242 TABLET 152 mg ORAL OTC monograph not final 12 sections