risperidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, risperidone derivatives 2389 106266-06-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • risperidone
  • ripedon
  • rispadal
  • risperdal
  • risperidal
  • R 64,766
  • okedi
A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
  • Molecular weight: 410.49
  • Formula: C23H27FN4O2
  • CLOGP: 2.71
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 61.94
  • ALOGS: -3.38
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
2.70 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.29 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.56 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 66 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 14, 2022 EMA LABORATORIOS FARMACEUTICOS ROVI, S.A.
Dec. 29, 1993 FDA JANSSEN PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperprolactinaemia 1584.88 11.55 468 95775 3432 63389347
Extrapyramidal disorder 1544.03 11.55 625 95618 12659 63380120
Suicide attempt 1493.23 11.55 1006 95237 59912 63332867
Neuroleptic malignant syndrome 1400.37 11.55 567 95676 11489 63381290
Blood prolactin increased 1138.63 11.55 354 95889 3149 63389630
Galactorrhoea 1135.92 11.55 368 95875 3787 63388992
Dystonia 989.16 11.55 462 95781 13357 63379422
Sedation 910.06 11.55 624 95619 38185 63354594
Intentional overdose 855.46 11.55 785 95458 73367 63319412
Dyskinesia 806.22 11.55 538 95705 31464 63361315
Intentional self-injury 795.96 11.55 492 95751 25195 63367584
Drug interaction 791.91 11.55 1318 94925 227813 63164966
Aggression 786.88 11.55 473 95770 23025 63369754
Blood prolactin abnormal 774.16 11.55 256 95987 2823 63389956
Sexual dysfunction 746.15 11.55 272 95971 4087 63388692
Anosognosia 725.29 11.55 246 95997 2950 63389829
Disturbance in social behaviour 724.02 11.55 260 95983 3733 63389046
Schizophrenia 700.67 11.55 329 95914 9623 63383156
Hallucination, auditory 690.42 11.55 353 95890 12471 63380308
Akathisia 667.57 11.55 310 95933 8836 63383943
Psychotic disorder 656.60 11.55 436 95807 25276 63367503
Metabolic disorder 647.23 11.55 274 95969 6229 63386550
Treatment noncompliance 610.25 11.55 483 95760 36842 63355937
Tardive dyskinesia 586.01 11.55 277 95966 8225 63384554
Somnolence 585.03 11.55 1004 95239 177681 63215098
Catatonia 583.84 11.55 229 96014 4248 63388531
Personality change 580.37 11.55 259 95984 6714 63386065
Parkinsonism 558.01 11.55 286 95957 10153 63382626
Amenorrhoea 519.48 11.55 268 95975 9646 63383133
Hypothermia 482.25 11.55 284 95959 13297 63379482
Delusion 468.41 11.55 267 95976 11750 63381029
Abnormal behaviour 444.98 11.55 320 95923 21106 63371673
Device leakage 433.94 11.55 213 96030 6883 63385896
Agitation 426.90 11.55 489 95754 59268 63333511
Pain 421.13 11.55 307 95936 740321 62652458
Arthralgia 413.35 11.55 174 96069 569536 62823243
Suicidal ideation 386.74 11.55 475 95768 61946 63330833
Salivary hypersecretion 383.76 11.55 201 96042 7465 63385314
Joint swelling 362.13 11.55 38 96205 327628 63065151
Syringe issue 357.44 11.55 142 96101 2727 63390052
Oculogyric crisis 342.11 11.55 120 96123 1601 63391178
Rheumatoid arthritis 328.44 11.55 13 96230 253806 63138973
Electrocardiogram QT prolonged 324.41 11.55 425 95818 59105 63333674
Muscle rigidity 322.81 11.55 207 96036 11293 63381486
Toxicity to various agents 322.34 11.55 963 95280 246287 63146492
Overdose 312.87 11.55 597 95646 114481 63278298
Completed suicide 312.40 11.55 685 95558 144988 63247791
Arthropathy 310.82 11.55 10 96233 234782 63157997
Sopor 297.72 11.55 256 95987 21908 63370871
Rash 294.87 11.55 251 95992 560620 62832159
Infusion related reaction 291.46 11.55 21 96222 245500 63147279
Fatigue 288.62 11.55 571 95672 887457 62505322
Delirium 284.98 11.55 367 95876 50174 63342605
Mania 280.59 11.55 195 96048 12172 63380607
Diarrhoea 279.00 11.55 409 95834 714957 62677822
Device malfunction 278.76 11.55 225 96018 17632 63375147
Abdominal discomfort 277.77 11.55 72 96171 320813 63071966
Alopecia 275.04 11.55 85 96158 337451 63055328
Synovitis 267.11 11.55 3 96240 186915 63205864
Hypomania 263.88 11.55 147 96096 6183 63386596
Pemphigus 262.31 11.55 3 96240 183723 63209056
Restlessness 260.81 11.55 270 95973 29183 63363596
Paranoia 255.29 11.55 180 96063 11499 63381280
Depressed level of consciousness 247.73 11.55 382 95861 61696 63331083
Systemic lupus erythematosus 233.83 11.55 23 96220 208895 63183884
Contraindicated product administered 226.09 11.55 31 96212 217617 63175162
Glossodynia 222.09 11.55 12 96231 178864 63213915
Sinusitis 215.90 11.55 41 96202 226612 63166167
Altered state of consciousness 213.92 11.55 226 96017 25004 63367775
Jaundice cholestatic 213.43 11.55 135 96108 7189 63385590
Peripheral swelling 212.93 11.55 69 96174 265873 63126906
Drug intolerance 208.19 11.55 104 96139 308557 63084222
Tachycardia 207.56 11.55 514 95729 117642 63275137
Swelling 207.53 11.55 79 96164 275299 63117480
Pruritus 200.56 11.55 153 96090 361300 63031479
Tremor 200.17 11.55 544 95699 131695 63261084
Headache 200.17 11.55 413 95830 632828 62759951
Weight increased 198.64 11.55 852 95391 259940 63132839
Pleurothotonus 193.64 11.55 74 96169 1275 63391504
Dyspnoea 190.43 11.55 454 95789 660859 62731920
Persecutory delusion 183.37 11.55 88 96155 2702 63390077
Hallucination 181.50 11.55 310 95933 54507 63338272
Hypersensitivity 176.70 11.55 113 96130 292572 63100207
Coma 173.64 11.55 333 95910 64031 63328748
Nausea 173.29 11.55 689 95554 853782 62538997
Nasopharyngitis 170.90 11.55 86 96157 254171 63138608
Hyperammonaemic encephalopathy 163.71 11.55 78 96165 2356 63390423
Diabetes mellitus 163.32 11.55 299 95944 55511 63337268
Cogwheel rigidity 156.98 11.55 71 96172 1899 63390880
Pericarditis 156.77 11.55 11 96232 131568 63261211
Psychomotor hyperactivity 153.09 11.55 128 96115 10535 63382244
Discomfort 151.64 11.55 34 96209 167340 63225439
Blood creatine phosphokinase increased 151.53 11.55 208 96035 30222 63362557
Pneumonia aspiration 149.76 11.55 221 96022 34319 63358460
Blood glucose increased 148.75 11.55 366 95877 83390 63309389
Stomatitis 143.43 11.55 20 96223 138705 63254074
Disturbance in attention 142.58 11.55 228 96015 37961 63354818
Mutism 133.87 11.55 60 96183 1570 63391209
Pain in extremity 131.17 11.55 187 96056 331299 63061480
Treatment failure 126.84 11.55 72 96171 198971 63193808
Irritability 126.33 11.55 195 96048 31499 63361280
Social avoidant behaviour 126.20 11.55 70 96173 2918 63389861
Drug hypersensitivity 126.18 11.55 172 96071 310515 63082264
Therapeutic product effect decreased 122.93 11.55 70 96173 193117 63199662
Rhabdomyolysis 121.73 11.55 230 96013 43721 63349058
Urinary retention 120.17 11.55 186 96057 30115 63362664
Cough 119.95 11.55 161 96082 292582 63100197
Hyponatraemia 119.13 11.55 407 95836 111493 63281286
Dysarthria 117.66 11.55 223 96020 42488 63350291
Mastitis 117.62 11.55 64 96179 2568 63390211
Psychomotor retardation 116.94 11.55 73 96170 3797 63388982
Disorientation 114.95 11.55 211 96032 39241 63353538
Urticaria 114.50 11.55 54 96189 165748 63227031
Serotonin syndrome 113.65 11.55 176 96067 28506 63364273
Pituitary tumour benign 113.41 11.55 57 96186 1938 63390841
Sluggishness 112.35 11.55 80 96163 5189 63387590
Hallucination, visual 110.08 11.55 141 96102 19157 63373622
Wound 109.96 11.55 55 96188 163208 63229571
Helicobacter infection 109.81 11.55 8 96235 92777 63300002
Mental impairment 106.39 11.55 119 96124 14032 63378747
Back pain 105.45 11.55 148 96095 263997 63128782
Psoriatic arthropathy 105.21 11.55 9 96234 91511 63301268
Urinary incontinence 104.56 11.55 180 96063 31834 63360945
Product dose omission issue 102.12 11.55 656 95587 233657 63159122
Impaired healing 100.92 11.55 17 96226 102525 63290254
Polydipsia 99.63 11.55 64 96179 3500 63389279
Infection 98.00 11.55 122 96121 229051 63163728
Rabbit syndrome 97.25 11.55 31 96212 301 63392478
Hypertonia 95.65 11.55 69 96174 4568 63388211
Hallucinations, mixed 95.39 11.55 70 96173 4759 63388020
Confusional state 95.26 11.55 649 95594 235731 63157048
Psychiatric symptom 94.89 11.55 72 96171 5151 63387628
Arthritis 94.59 11.55 29 96214 115892 63276887
Hypotension 94.05 11.55 721 95522 271883 63120896
Logorrhoea 93.06 11.55 54 96189 2456 63390323
Folliculitis 92.94 11.55 3 96240 70314 63322465
Drooling 92.47 11.55 63 96180 3805 63388974
Hyperthermia 92.16 11.55 90 96153 9066 63383713
Lower respiratory tract infection 91.48 11.55 43 96200 132264 63260515
Intentional product use issue 89.29 11.55 41 96202 127851 63264928
Sudden death 89.27 11.55 94 96149 10355 63382424
COVID-19 89.26 11.55 30 96213 113073 63279706
Stupor 89.06 11.55 64 96179 4211 63388568
Miosis 88.84 11.55 80 96163 7273 63385506
Febrile neutropenia 87.44 11.55 35 96208 118414 63274365
Psychotic symptom 86.98 11.55 44 96199 1517 63391262
Inappropriate affect 85.93 11.55 37 96206 877 63391902
Psychiatric decompensation 85.48 11.55 42 96201 1359 63391420
Gestational diabetes 83.52 11.55 82 96161 8314 63384465
Somatic symptom disorder of pregnancy 81.69 11.55 21 96222 84 63392695
Sinus tachycardia 81.29 11.55 138 96105 24130 63368649
Blister 81.18 11.55 48 96195 129766 63263013
Mental disorder 81.08 11.55 143 96100 25776 63367003
Medication error 78.91 11.55 215 96028 52069 63340710
Accidental exposure to product 77.85 11.55 145 96098 27260 63365519
Oromandibular dystonia 75.97 11.55 29 96214 498 63392281
Injection site pain 75.67 11.55 52 96191 129748 63263031
Antipsychotic drug level increased 75.19 11.55 53 96190 3382 63389397
Torticollis 75.11 11.55 43 96200 1906 63390873
Anxiety 74.77 11.55 575 95668 216966 63175813
Bradycardia 74.12 11.55 262 95981 72965 63319814
Obsessive-compulsive disorder 73.82 11.55 56 96187 4004 63388775
Fibromyalgia 73.48 11.55 16 96227 80404 63312375
Gastrointestinal disorder 73.34 11.55 55 96188 131184 63261595
Apathy 73.15 11.55 78 96165 8716 63384063
Seizure 72.99 11.55 395 95848 132239 63260540
Thinking abnormal 72.41 11.55 85 96158 10558 63382221
Osteoarthritis 72.31 11.55 27 96216 95316 63297463
Refusal of examination 72.24 11.55 22 96221 181 63392598
Embolism venous 72.16 11.55 50 96193 3104 63389675
Electroencephalogram abnormal 72.02 11.55 53 96190 3619 63389160
Exposure to contaminated device 71.92 11.55 14 96229 6 63392773
Respiratory depression 71.69 11.55 96 96147 13619 63379160
Abdominal pain upper 71.59 11.55 127 96116 206317 63186462
Maternal exposure during pregnancy 71.36 11.55 141 96102 219921 63172858
Hospitalisation 70.87 11.55 286 95957 84795 63307984
Neuropathy peripheral 69.71 11.55 43 96200 113624 63279155
Impulsive behaviour 69.37 11.55 38 96205 1545 63391234
Affective disorder 68.67 11.55 64 96179 6082 63386697
Chest discomfort 68.28 11.55 41 96202 109928 63282851
Eosinophil count decreased 67.91 11.55 42 96201 2148 63390631
Migraine 66.34 11.55 37 96206 103309 63289470
Generalised tonic-clonic seizure 66.12 11.55 140 96103 28876 63363903
Psychomotor skills impaired 64.90 11.55 42 96201 2326 63390453
Irritable bowel syndrome 64.78 11.55 22 96221 82390 63310389
Erythema 64.73 11.55 104 96139 175647 63217132
Withdrawal syndrome 64.72 11.55 112 96131 19885 63372894
Malignant catatonia 64.09 11.55 20 96223 180 63392599
Injection site erythema 64.01 11.55 23 96220 83151 63309628
Anaemia 63.35 11.55 230 96013 293200 63099579
Disease progression 62.93 11.55 56 96187 122702 63270077
Autonomic nervous system imbalance 62.90 11.55 44 96199 2774 63390005
Asthma 62.08 11.55 61 96182 127500 63265279
Obesity 61.97 11.55 139 96104 29813 63362966
Herpes zoster 61.45 11.55 24 96219 82438 63310341
Leukopenia 61.36 11.55 256 95987 77034 63315745
Prolactin-producing pituitary tumour 61.33 11.55 17 96226 96 63392683
Granulocytopenia 61.33 11.55 58 96185 5614 63387165
Hypoaesthesia 60.75 11.55 101 96142 168292 63224487
Knee arthroplasty 60.50 11.55 6 96237 54200 63338579
Asthma-chronic obstructive pulmonary disease overlap syndrome 60.07 11.55 38 96205 2023 63390756
Contusion 59.89 11.55 84 96159 149960 63242819
Ataxia 59.85 11.55 93 96150 15102 63377677
Bradykinesia 59.85 11.55 55 96188 5133 63387646
Inflammation 59.59 11.55 25 96218 82248 63310531
Dysphagia 57.95 11.55 277 95966 88308 63304471
C-reactive protein abnormal 57.46 11.55 3 96240 46093 63346686
Inappropriate antidiuretic hormone secretion 57.26 11.55 92 96151 15370 63377409
Tic 57.15 11.55 33 96210 1487 63391292
Condition aggravated 57.13 11.55 891 95352 401326 62991453
Fall 56.83 11.55 872 95371 391462 63001317
Incoherent 56.14 11.55 50 96193 4480 63388299
Total lung capacity increased 56.11 11.55 38 96205 2272 63390507
Ileus paralytic 55.94 11.55 50 96193 4501 63388278
Flushing 55.71 11.55 22 96221 75065 63317714
Plasma cell mastitis 55.61 11.55 13 96230 31 63392748
Dyspepsia 55.60 11.55 44 96199 102152 63290627
Floppy iris syndrome 55.55 11.55 16 96227 106 63392673
Anticholinergic syndrome 55.06 11.55 38 96205 2344 63390435
Faecaloma 54.99 11.55 64 96179 7877 63384902
Bronchitis 54.96 11.55 65 96178 124870 63267909
Malignant neoplasm progression 54.76 11.55 28 96215 82093 63310686
Myalgia 54.62 11.55 86 96157 146443 63246336
Malaise 54.45 11.55 388 95855 415566 62977213
Torsade de pointes 54.39 11.55 83 96160 13268 63379511
Dementia 54.08 11.55 100 96143 18694 63374085
Insurance issue 53.96 11.55 56 96187 6065 63386714
Drug abuse 53.55 11.55 235 96008 72283 63320496
Wrong patient received product 52.88 11.55 36 96207 2171 63390608
Psychotic behaviour 52.21 11.55 23 96220 577 63392202
Hyperreflexia 51.79 11.55 54 96189 5880 63386899
Dyspnoea exertional 51.18 11.55 14 96229 60288 63332491
Epilepsy 50.93 11.55 121 96122 26944 63365835
Impaired self-care 50.84 11.55 33 96210 1837 63390942
Injection site reaction 50.78 11.55 13 96230 58511 63334268
Personality change due to a general medical condition 50.63 11.55 17 96226 197 63392582
Influenza 50.62 11.55 54 96189 108668 63284111
Needle issue 50.25 11.55 70 96173 10306 63382473
Asthenia 50.11 11.55 358 95885 383246 63009533
Hyperphagia 49.86 11.55 32 96211 1747 63391032
Bradyphrenia 49.58 11.55 57 96186 6923 63385856
Hypokinesia 49.01 11.55 81 96162 13855 63378924
Drug level increased 48.71 11.55 107 96136 22629 63370150
Musculoskeletal pain 48.62 11.55 41 96202 92236 63300543
Protrusion tongue 48.49 11.55 19 96224 351 63392428
Refusal of treatment by patient 47.93 11.55 50 96193 5447 63387332
Abdominal pain 47.58 11.55 256 95987 293200 63099579
Product container issue 47.18 11.55 31 96212 1762 63391017
Increased appetite 46.69 11.55 65 96178 9565 63383214
Cardio-respiratory arrest 46.34 11.55 197 96046 59762 63333017
Breast discharge 46.33 11.55 25 96218 986 63391793
Cystoid macular oedema 45.81 11.55 29 96214 1546 63391233
Antipsychotic drug level above therapeutic 45.60 11.55 25 96218 1018 63391761
Echolalia 45.57 11.55 16 96227 214 63392565
Flat affect 45.45 11.55 28 96215 1422 63391357
Homicidal ideation 45.39 11.55 30 96213 1722 63391057
Psoriasis 45.37 11.55 39 96204 86918 63305861
Diabetic coma 45.26 11.55 22 96221 695 63392084
Bipolar disorder 45.14 11.55 58 96185 7902 63384877
Intellectual disability 44.66 11.55 25 96218 1061 63391718
Soliloquy 44.46 11.55 16 96227 231 63392548
Nasal congestion 44.36 11.55 22 96221 65638 63327141
Rhinorrhoea 44.26 11.55 22 96221 65555 63327224
Influenza like illness 44.23 11.55 23 96220 66801 63325978
Abnormal weight gain 44.20 11.55 30 96213 1800 63390979
Bone pain 43.97 11.55 14 96229 54627 63338152
Myoclonus 43.87 11.55 83 96160 15785 63376994
Ill-defined disorder 43.47 11.55 36 96207 81719 63311060
Abulia 43.23 11.55 19 96224 474 63392305
Bipolar I disorder 43.20 11.55 30 96213 1869 63390910
Pulmonary fibrosis 42.91 11.55 5 96238 39804 63352975
Spasmodic dysphonia 42.68 11.55 12 96231 72 63392707
Throat irritation 42.45 11.55 4 96239 37643 63355136
Activation syndrome 42.29 11.55 15 96228 207 63392572
Negative symptoms in schizophrenia 42.26 11.55 13 96230 111 63392668
Hypersexuality 42.19 11.55 19 96224 503 63392276
Phagophobia 41.66 11.55 11 96232 50 63392729
Grandiosity 41.43 11.55 16 96227 284 63392495
Drug withdrawal syndrome 41.19 11.55 112 96131 27082 63365697
Movement disorder 40.93 11.55 97 96146 21564 63371215
Breast hyperplasia 40.82 11.55 16 96227 296 63392483
Lactation disorder 40.69 11.55 17 96226 373 63392406
Metabolic syndrome 40.68 11.55 27 96216 1561 63391218
Chest pain 40.42 11.55 179 96064 215780 63176999
Weight decreased 40.29 11.55 250 95993 276548 63116231
Blood bilirubin increased 40.28 11.55 136 96107 37004 63355775
Night sweats 40.19 11.55 12 96231 48802 63343977
Paraesthesia 40.14 11.55 114 96129 156852 63235927
Reduced facial expression 39.97 11.55 29 96214 1937 63390842
Mobility decreased 39.79 11.55 77 96166 121082 63271697
Schizoaffective disorder 39.62 11.55 37 96206 3525 63389254
Oropharyngeal pain 39.61 11.55 51 96192 94436 63298343
Negativism 39.60 11.55 17 96226 400 63392379
Product tampering 39.56 11.55 17 96226 401 63392378
Cholelithiasis 39.26 11.55 151 96092 43774 63349005
Mood swings 39.23 11.55 86 96157 18162 63374617
Water intoxication 39.21 11.55 17 96226 410 63392369
Rash pruritic 38.96 11.55 21 96222 59778 63333001
Menstrual disorder 38.77 11.55 44 96199 5269 63387510
Loss of consciousness 38.75 11.55 309 95934 117812 63274967
Productive cough 38.62 11.55 24 96219 63184 63329595
Hypotonia 38.22 11.55 58 96185 9227 63383552
Product use issue 38.19 11.55 188 96055 220332 63172447
Communication disorder 37.95 11.55 31 96212 2469 63390310
Poisoning deliberate 37.84 11.55 64 96179 11154 63381625
Gynaecomastia 37.81 11.55 14 96229 220 63392559
Product administration error 37.76 11.55 96 96147 22301 63370478
Red blood cell sedimentation rate increased 37.72 11.55 10 96233 43972 63348807
Aphasia 37.71 11.55 123 96120 32877 63359902
Myocarditis 37.64 11.55 61 96182 10264 63382515
Thermal burn 37.38 11.55 46 96197 6000 63386779
Binge eating 37.23 11.55 17 96226 465 63392314
Major depression 37.21 11.55 53 96190 7965 63384814
Personality disorder 37.21 11.55 45 96198 5766 63387013
Pulmonary embolism 37.06 11.55 303 95940 116381 63276398
Hepatotoxicity 37.01 11.55 132 96111 36909 63355870
Obsessive thoughts 36.90 11.55 18 96225 573 63392206
Hostility 36.67 11.55 27 96216 1845 63390934
Speech disorder 36.58 11.55 140 96103 40489 63352290
Adulterated product 36.48 11.55 14 96229 244 63392535
Breast discomfort 36.47 11.55 17 96226 488 63392291
Device expulsion 36.15 11.55 5 96238 34917 63357862
Cognitive disorder 36.11 11.55 174 96069 55641 63337138
Compulsions 35.25 11.55 13 96230 202 63392577
Injection site bruising 35.06 11.55 10 96233 41900 63350879
Oropharyngeal spasm 34.99 11.55 14 96229 274 63392505
Oesophageal atresia 34.95 11.55 17 96226 538 63392241
Mydriasis 34.88 11.55 64 96179 11892 63380887
Bursitis 34.59 11.55 7 96236 37034 63355745
Diabetes insipidus 34.59 11.55 30 96213 2595 63390184
Precocious puberty 34.50 11.55 13 96230 215 63392564
Vomiting 34.20 11.55 620 95623 558997 62833782
Injection site pruritus 33.82 11.55 13 96230 45103 63347676
Hemivertebra 33.52 11.55 11 96232 118 63392661
Foreign body 33.42 11.55 28 96215 2310 63390469
Osteoporosis 33.36 11.55 23 96220 57315 63335464
Fluid retention 33.35 11.55 25 96218 59661 63333118
Diet refusal 33.16 11.55 17 96226 603 63392176
Morbid thoughts 33.08 11.55 17 96226 606 63392173
Mental status changes 32.86 11.55 133 96110 39466 63353313
Anaphylactic reaction 32.86 11.55 31 96212 66069 63326710
Pneumonia 32.85 11.55 491 95752 456276 62936503
Distractibility 32.23 11.55 15 96228 429 63392350
Emotional poverty 32.01 11.55 14 96229 345 63392434
Underdose 31.97 11.55 103 96140 27353 63365426
Intentional product misuse 31.86 11.55 179 96064 60738 63332041
Blood pressure systolic increased 31.83 11.55 16 96227 47381 63345398
Tension 31.56 11.55 31 96212 3144 63389635
Substance-induced psychotic disorder 31.32 11.55 25 96218 1926 63390853
Oxygen saturation decreased 31.13 11.55 54 96189 88531 63304248
Pulse abnormal 31.11 11.55 27 96216 2337 63390442
Antipsychotic drug level below therapeutic 30.71 11.55 13 96230 295 63392484
Upper respiratory tract infection 30.71 11.55 48 96195 81999 63310780
Therapy interrupted 30.58 11.55 6 96237 32449 63360330
Affect lability 30.42 11.55 58 96185 11093 63381686
Substance abuse 30.41 11.55 37 96206 4770 63388009
Hepatocellular injury 30.34 11.55 101 96142 27280 63365499
Somatic symptom disorder 30.30 11.55 28 96215 2632 63390147
Hypertension 30.27 11.55 274 95969 279029 63113750
Parkinsonian gait 30.01 11.55 15 96228 504 63392275
Potentiating drug interaction 29.98 11.55 35 96208 4321 63388458
Interstitial lung disease 29.65 11.55 30 96213 61878 63330901
Hypotonic urinary bladder 29.57 11.55 7 96236 18 63392761
Cystitis 29.50 11.55 24 96219 54967 63337812
Cardiac failure congestive 29.26 11.55 60 96183 92373 63300406
Mouth ulceration 29.25 11.55 7 96236 32977 63359802
Hypernatraemia 29.17 11.55 46 96197 7563 63385216
Altered visual depth perception 29.15 11.55 13 96230 336 63392443
Injection site swelling 29.15 11.55 18 96225 47554 63345225
Wrong dose 29.13 11.55 20 96223 1223 63391556
Dry skin 29.08 11.55 26 96217 56861 63335918
Screaming 29.03 11.55 30 96213 3232 63389547
Basal cell carcinoma 28.99 11.55 4 96239 27987 63364792
Pituitary tumour 28.94 11.55 18 96225 930 63391849
Orthostatic hypotension 28.86 11.55 120 96123 36040 63356739
Poriomania 28.65 11.55 9 96234 83 63392696
Joint range of motion decreased 28.52 11.55 7 96236 32421 63360358
Depressive symptom 28.30 11.55 33 96210 4069 63388710
Skin ulcer 28.21 11.55 15 96228 43030 63349749
Neoplasm progression 28.14 11.55 10 96233 36418 63356361
Oligomenorrhoea 28.13 11.55 17 96226 834 63391945
Cellulitis 27.86 11.55 51 96192 81907 63310872
Hot flush 27.85 11.55 22 96221 51137 63341642
Polyuria 27.85 11.55 48 96195 8494 63384285
Claustrophobia 27.76 11.55 18 96225 1000 63391779
Acute psychosis 27.64 11.55 26 96217 2499 63390280
Unresponsive to stimuli 27.60 11.55 113 96130 33703 63359076
Full blood count abnormal 27.60 11.55 7 96236 31710 63361069
Slow response to stimuli 27.54 11.55 18 96225 1014 63391765
Megacolon 27.51 11.55 23 96220 1892 63390887
Plasma cell myeloma 27.50 11.55 10 96233 35895 63356884
Pain in jaw 27.29 11.55 16 96227 43480 63349299
Lethargy 26.96 11.55 161 96082 55846 63336933
Encephalopathy 26.88 11.55 123 96120 38497 63354282
Product reconstitution quality issue 26.69 11.55 8 96235 62 63392717
Nasal polyps 26.68 11.55 39 96204 6000 63386779
Chorea 26.48 11.55 21 96222 1603 63391176
Macular degeneration 26.43 11.55 3 96240 24373 63368406
Intracranial pressure increased 26.42 11.55 36 96207 5191 63387588
Ulcer 26.42 11.55 4 96239 26103 63366676
Hyperammonaemia 26.39 11.55 36 96207 5196 63387583
Breast enlargement 26.34 11.55 21 96222 1615 63391164
Pemphigoid 26.24 11.55 43 96200 7301 63385478
Brain injury 26.21 11.55 42 96201 7001 63385778
Idiopathic intracranial hypertension 26.17 11.55 27 96216 2904 63389875
Device occlusion 26.06 11.55 43 96200 7344 63385435
Anger 25.98 11.55 58 96185 12398 63380381
Behaviour disorder 25.95 11.55 28 96215 3171 63389608
Blood pressure increased 25.89 11.55 142 96101 161920 63230859
Target skin lesion 25.87 11.55 9 96234 117 63392662
Cerebral atrophy 25.77 11.55 35 96208 5031 63387748
Chills 25.68 11.55 87 96156 113291 63279488
Diverticulitis 25.61 11.55 14 96229 39543 63353236
Multiple organ dysfunction syndrome 25.51 11.55 29 96214 56723 63336056
Posture abnormal 25.51 11.55 24 96219 2308 63390471
Regurgitation 25.48 11.55 21 96222 1693 63391086
Bladder dilatation 25.48 11.55 16 96227 841 63391938
Type 2 diabetes mellitus 25.44 11.55 175 96068 63693 63329086
Electrocardiogram abnormal 25.36 11.55 48 96195 9131 63383648
Muscular weakness 25.00 11.55 98 96145 122255 63270524
Hyperlactacidaemia 24.99 11.55 26 96217 2823 63389956
Paradoxical drug reaction 24.72 11.55 31 96212 4121 63388658
Gaze palsy 24.53 11.55 19 96224 1401 63391378
Hepatic enzyme increased 24.38 11.55 193 96050 202135 63190644
Disorganised speech 24.23 11.55 18 96225 1247 63391532
Oral herpes 24.19 11.55 5 96238 26069 63366710
Compartment syndrome 24.02 11.55 23 96220 2261 63390518
Endocarditis fibroplastica 24.01 11.55 5 96238 5 63392774
Sciatica 23.95 11.55 11 96232 34313 63358466
Multiple sclerosis relapse 23.78 11.55 23 96220 48455 63344324
Type 1 diabetes mellitus 23.70 11.55 29 96214 3761 63389018
Cardiac output decreased 23.63 11.55 16 96227 956 63391823
Pleural effusion 23.59 11.55 68 96175 93142 63299637
Resting tremor 23.55 11.55 15 96228 808 63391971
Stress 23.54 11.55 41 96202 67126 63325653
Circulatory collapse 23.49 11.55 80 96163 21858 63370921
Inappropriate schedule of product administration 23.46 11.55 251 95992 103714 63289065
Oedema 23.43 11.55 73 96170 97549 63295230
Stereotypy 23.30 11.55 12 96231 430 63392349
Lack of spontaneous speech 23.29 11.55 9 96234 160 63392619
Dementia with Lewy bodies 23.25 11.55 11 96232 327 63392452
Loss of libido 23.20 11.55 18 96225 1331 63391448
Sarcoidosis 23.19 11.55 40 96203 7082 63385697
Antidiuretic hormone abnormality 23.14 11.55 6 96237 25 63392754
Neglect of personal appearance 23.06 11.55 8 96235 103 63392676
Optic nerve injury 22.94 11.55 13 96230 565 63392214
Pyrexia 22.85 11.55 541 95702 469937 62922842
Brain contusion 22.79 11.55 13 96230 572 63392207
Eating disorder 22.74 11.55 72 96171 18944 63373835
Foot deformity 22.65 11.55 7 96236 27846 63364933
Blood triglycerides increased 22.60 11.55 55 96188 12433 63380346
Procedural pain 22.54 11.55 3 96240 21566 63371213
Dementia Alzheimer's type 22.38 11.55 16 96227 1044 63391735
Haematochezia 22.33 11.55 29 96214 53515 63339264
Amaurosis 22.31 11.55 13 96230 596 63392183
Frontotemporal dementia 22.22 11.55 11 96232 362 63392417
Muscle spasms 22.19 11.55 142 96101 156008 63236771
Hypoosmolar state 22.18 11.55 9 96234 183 63392596
Full blood count decreased 22.16 11.55 6 96237 26018 63366761
Cytotoxic oedema 22.13 11.55 9 96234 184 63392595
Decreased gait velocity 21.99 11.55 5 96238 10 63392769
Caput succedaneum 21.99 11.55 5 96238 10 63392769
Device use confusion 21.97 11.55 4 96239 0 63392779
Drug withdrawal syndrome neonatal 21.97 11.55 21 96222 2060 63390719
Osteonecrosis of jaw 21.92 11.55 13 96230 35110 63357669
Product quality issue 21.90 11.55 110 96133 35755 63357024
Dysphoria 21.84 11.55 32 96211 4934 63387845
Clostridium difficile infection 21.81 11.55 9 96234 29913 63362866
Ventricular extrasystoles 21.71 11.55 52 96191 11635 63381144
Cytomegalovirus infection 21.69 11.55 3 96240 20949 63371830
Bundle branch block right 21.68 11.55 32 96211 4966 63387813
Pulmonary mass 21.67 11.55 4 96239 22592 63370187
Pulmonary arterial hypertension 21.64 11.55 4 96239 22573 63370206
Respiratory dyskinesia 21.63 11.55 6 96237 34 63392745
Disease recurrence 21.57 11.55 92 96151 27938 63364841
Attention-seeking behaviour 21.51 11.55 7 96236 73 63392706
Tourette's disorder 21.37 11.55 5 96238 12 63392767
Myocarditis septic 21.34 11.55 6 96237 36 63392743
Injury associated with device 21.24 11.55 27 96216 3639 63389140
Nuchal rigidity 21.18 11.55 13 96230 656 63392123
Respiratory tract infection 21.15 11.55 19 96224 41464 63351315
Cardiac arrest 21.14 11.55 224 96019 92321 63300458
Sinus bradycardia 21.11 11.55 59 96184 14492 63378287
Oesophageal food impaction 21.11 11.55 9 96234 208 63392571
Postmortem blood drug level 21.08 11.55 8 96235 135 63392644
Mucosal inflammation 21.07 11.55 24 96219 46904 63345875
Transient aphasia 21.06 11.55 6 96237 38 63392741
Anaphylactic shock 20.98 11.55 5 96238 23628 63369151
Neurological symptom 20.85 11.55 34 96209 5749 63387030
Euphoric mood 20.78 11.55 31 96212 4856 63387923
Cataract 20.76 11.55 34 96209 57019 63335760
Immunodeficiency 20.73 11.55 3 96240 20251 63372528
Withdrawal catatonia 20.70 11.55 7 96236 83 63392696
Platelet count decreased 20.66 11.55 98 96145 116024 63276755
Neonatal tachypnoea 20.61 11.55 8 96235 144 63392635
Localised infection 20.59 11.55 10 96233 30200 63362579
Colitis 20.53 11.55 26 96217 48502 63344277
Colitis ulcerative 20.44 11.55 7 96236 26084 63366695
Gastric disorder 20.43 11.55 16 96227 37353 63355426
Grimacing 20.41 11.55 11 96232 433 63392346
Locked-in syndrome 20.41 11.55 11 96232 433 63392346
Status epilepticus 20.39 11.55 60 96183 15173 63377606
Product use in unapproved indication 20.36 11.55 383 95860 178697 63214082
Staring 20.22 11.55 18 96225 1612 63391167
Muscle enzyme increased 20.21 11.55 8 96235 152 63392627
Fear 20.06 11.55 61 96182 15705 63377074
Attention deficit hyperactivity disorder 19.99 11.55 24 96219 3052 63389727
Hypervolaemia 19.99 11.55 9 96234 28404 63364375
Convulsive threshold lowered 19.84 11.55 10 96233 342 63392437
Agranulocytosis 19.74 11.55 83 96160 25051 63367728
Optic atrophy 19.72 11.55 16 96227 1262 63391517
Parachute mitral valve 19.71 11.55 7 96236 97 63392682
Thrombosis 19.69 11.55 43 96200 64712 63328067
Skin discolouration 19.68 11.55 17 96226 37811 63354968
Encephalitis autoimmune 19.61 11.55 17 96226 1469 63391310
Injury 19.61 11.55 52 96191 73195 63319584
Breast engorgement 19.58 11.55 7 96236 99 63392680
Amimia 19.33 11.55 6 96237 53 63392726
Tongue biting 19.28 11.55 17 96226 1503 63391276
Gastrointestinal haemorrhage 19.27 11.55 61 96182 81115 63311664
Urinary tract infection staphylococcal 19.27 11.55 10 96233 364 63392415
Eye movement disorder 19.21 11.55 31 96212 5197 63387582
Gastroenteritis viral 19.19 11.55 6 96237 23694 63369085
Pre-existing disease 18.88 11.55 8 96235 182 63392597
Long QT syndrome 18.76 11.55 24 96219 3255 63389524
Fungal infection 18.67 11.55 17 96226 36857 63355922
Choreoathetosis 18.61 11.55 11 96232 518 63392261
Menstruation irregular 18.58 11.55 36 96207 6968 63385811
Oral pain 18.45 11.55 10 96233 28384 63364395
Dyslipidaemia 18.40 11.55 37 96206 7356 63385423
Atrioventricular block second degree 18.35 11.55 26 96217 3888 63388891
Device dislocation 18.31 11.55 8 96235 25697 63367082
Dizziness 18.29 11.55 504 95739 429421 62963358
Hepatic cytolysis 18.12 11.55 58 96185 15349 63377430
Pneumonitis 18.12 11.55 16 96227 35206 63357573
Tubulointerstitial nephritis 18.09 11.55 4 96239 19899 63372880
Wrong product administered 18.07 11.55 33 96210 6108 63386671
Breast tenderness 18.07 11.55 20 96223 2330 63390449
Drug reaction with eosinophilia and systemic symptoms 18.07 11.55 100 96143 33736 63359043
Congenital ureteric anomaly 17.99 11.55 6 96237 68 63392711
Depression 17.98 11.55 407 95836 196085 63196694
Suicidal behaviour 17.82 11.55 21 96222 2618 63390161
Maternal drugs affecting foetus 17.80 11.55 30 96213 5212 63387567
Dysgeusia 17.79 11.55 27 96216 46683 63346096
Respiratory arrest 17.78 11.55 97 96146 32548 63360231
Gastrointestinal sounds abnormal 17.66 11.55 26 96217 4025 63388754
Surgery 17.66 11.55 17 96226 35895 63356884
Blood calcium decreased 17.66 11.55 9 96234 26442 63366337
Metastases to bone 17.61 11.55 5 96238 21014 63371765
Meige's syndrome 17.59 11.55 4 96239 8 63392771
Product physical issue 17.58 11.55 29 96214 4951 63387828
Musculoskeletal stiffness 17.51 11.55 187 96056 184431 63208348
CSF pressure increased 17.35 11.55 7 96236 140 63392639
Fibrin D dimer increased 17.35 11.55 29 96214 5005 63387774
Decreased appetite 17.28 11.55 272 95971 250780 63141999
Nephrolithiasis 17.24 11.55 23 96220 41961 63350818
Bedridden 17.22 11.55 46 96197 11005 63381774
Wrong technique in product usage process 17.22 11.55 157 96086 62183 63330596
Osteomyelitis 17.15 11.55 9 96234 26011 63366768
Phobia 16.91 11.55 9 96234 345 63392434
Retinal ischaemia 16.87 11.55 9 96234 347 63392432
Opisthotonus 16.87 11.55 9 96234 347 63392432
Product substitution issue 16.84 11.55 58 96185 15938 63376841
Wheezing 16.82 11.55 81 96162 95514 63297265
Aspiration 16.74 11.55 45 96198 10806 63381973
Neonatal respiratory distress syndrome 16.72 11.55 21 96222 2797 63389982
Incontinence 16.72 11.55 47 96196 11585 63381194
Tachyphrenia 16.70 11.55 15 96228 1359 63391420
Enuresis 16.60 11.55 20 96223 2553 63390226
Areflexia 16.56 11.55 22 96221 3096 63389683
Neck pain 16.51 11.55 52 96191 69266 63323513
Hirsutism 16.50 11.55 15 96228 1380 63391399
Hysterical psychosis 16.48 11.55 3 96240 0 63392779
Oppositional defiant disorder 16.43 11.55 5 96238 41 63392738
Cataract cortical 16.43 11.55 5 96238 41 63392738
Blunted affect 16.39 11.55 8 96235 255 63392524
Suspiciousness 16.34 11.55 9 96234 370 63392409
Labelled drug-drug interaction medication error 16.27 11.55 51 96192 13348 63379431
Cholangitis sclerosing 16.27 11.55 16 96227 1625 63391154
Hypoprolactinaemia 16.21 11.55 4 96239 13 63392766
Product leakage 16.18 11.55 12 96231 829 63391950
Tenderness 16.12 11.55 7 96236 22571 63370208
Drug abuser 16.11 11.55 21 96222 2902 63389877
Alcohol abuse 16.05 11.55 18 96225 2128 63390651
Femur fracture 16.03 11.55 24 96219 41732 63351047
Alcohol interaction 15.99 11.55 19 96224 2390 63390389
Flank pain 15.98 11.55 58 96185 16352 63376427
Bed bug infestation 15.98 11.55 4 96239 14 63392765
Delusional disorder, unspecified type 15.95 11.55 9 96234 388 63392391
Merycism 15.89 11.55 8 96235 273 63392506
Tachypnoea 15.89 11.55 60 96183 17242 63375537
Nodule 15.86 11.55 6 96237 21020 63371759
Facial spasm 15.80 11.55 11 96232 688 63392091
Delusion of reference 15.77 11.55 6 96237 102 63392677
Hyperdynamic left ventricle 15.77 11.55 7 96236 179 63392600
Seasonal allergy 15.76 11.55 6 96237 20944 63371835
Epistaxis 15.66 11.55 57 96186 72668 63320111
Ear pain 15.65 11.55 19 96224 36099 63356680
Ear infection 15.63 11.55 21 96222 38192 63354587
Pulmonary vein occlusion 15.61 11.55 6 96237 105 63392674
Trismus 15.61 11.55 24 96219 3861 63388918
Poisoning 15.59 11.55 51 96192 13649 63379130
Sinus disorder 15.45 11.55 9 96234 24544 63368235
Exostosis 15.43 11.55 4 96239 17858 63374921
Dermatosis 15.37 11.55 8 96235 293 63392486
Spinal shock 15.37 11.55 4 96239 17 63392762
Nystagmus 15.33 11.55 31 96212 6189 63386590
Conversion disorder 15.30 11.55 16 96227 1748 63391031
Cortisol increased 15.30 11.55 9 96234 420 63392359
Cardiac disorder 15.23 11.55 34 96209 50782 63341997
Blood cholesterol increased 15.22 11.55 82 96161 93950 63298829
Joint stiffness 15.19 11.55 25 96218 41844 63350935
Feeling guilty 15.16 11.55 10 96233 572 63392207
Acute generalised exanthematous pustulosis 15.13 11.55 44 96199 11055 63381724
Palmar-plantar erythrodysaesthesia syndrome 15.11 11.55 8 96235 23007 63369772
Xanthopsia 15.05 11.55 7 96236 200 63392579
Somatic delusion 15.01 11.55 10 96233 582 63392197
Affective ambivalence 15.01 11.55 4 96239 19 63392760
Feeling hot 14.84 11.55 34 96209 50320 63342459
Haemoptysis 14.84 11.55 13 96230 28713 63364066
Akinesia 14.81 11.55 15 96228 1578 63391201
Injection site rash 14.81 11.55 5 96238 18804 63373975
Nephrogenic diabetes insipidus 14.78 11.55 12 96231 947 63391832
Bronchospasm 14.68 11.55 4 96239 17276 63375503
Hepatitis 14.66 11.55 107 96136 39681 63353098
Transient tachypnoea of the newborn 14.65 11.55 6 96237 125 63392654
Bone disorder 14.62 11.55 7 96236 21319 63371460
Neurological decompensation 14.61 11.55 19 96224 2619 63390160
Pulmonary hypertension 14.58 11.55 21 96222 37102 63355677
Rhinitis allergic 14.58 11.55 45 96198 11682 63381097
Brain oedema 14.53 11.55 51 96192 14144 63378635
Exposure during pregnancy 14.48 11.55 323 95920 155224 63237555
Bruxism 14.48 11.55 22 96221 3503 63389276
Myelosuppression 14.48 11.55 9 96234 23694 63369085
Dyslalia 14.42 11.55 9 96234 468 63392311
Obsessive rumination 14.41 11.55 3 96240 3 63392776
Disruptive mood dysregulation disorder 14.41 11.55 3 96240 3 63392776
Metastases to liver 14.40 11.55 9 96234 23630 63369149
Feelings of worthlessness 14.37 11.55 8 96235 336 63392443
Polydipsia psychogenic 14.30 11.55 5 96238 66 63392713
Lip dry 14.28 11.55 3 96240 15467 63377312
Laryngitis 14.28 11.55 4 96239 16963 63375816
Mood altered 14.27 11.55 52 96191 14691 63378088
Grip strength decreased 14.26 11.55 8 96235 22279 63370500
Oesophageal achalasia 14.26 11.55 9 96234 477 63392302
Body mass index increased 14.20 11.55 13 96230 1207 63391572
Illness anxiety disorder 14.18 11.55 6 96237 136 63392643
Cardiovascular symptom 14.16 11.55 5 96238 68 63392711
Infusion site pain 14.15 11.55 4 96239 16865 63375914
Ascites 14.15 11.55 25 96218 40703 63352076
Device related infection 14.12 11.55 9 96234 23383 63369396
Meningism 14.11 11.55 9 96234 486 63392293
Sneezing 14.07 11.55 5 96238 18213 63374566
Heart rate decreased 14.06 11.55 30 96213 45530 63347249
Obsessive-compulsive symptom 14.03 11.55 5 96238 70 63392709
Suspected suicide attempt 14.02 11.55 6 96237 140 63392639
Food interaction 14.02 11.55 11 96232 827 63391952
CSF glucose decreased 13.97 11.55 5 96238 71 63392708
Hypotonia neonatal 13.97 11.55 13 96230 1233 63391546
Lung disorder 13.94 11.55 48 96195 62213 63330566
Severe myoclonic epilepsy of infancy 13.90 11.55 5 96238 72 63392707
Onychophagia 13.90 11.55 5 96238 72 63392707
Diabetic neuropathy 13.88 11.55 23 96220 3941 63388838
Blood pressure fluctuation 13.88 11.55 31 96212 46286 63346493
Hypoxic-ischaemic encephalopathy 13.86 11.55 24 96219 4263 63388516
Musculoskeletal discomfort 13.76 11.55 5 96238 17962 63374817
Parkinsonism hyperpyrexia syndrome 13.75 11.55 6 96237 147 63392632
Foetal macrosomia 13.72 11.55 5 96238 75 63392704
Lower limb fracture 13.71 11.55 10 96233 24211 63368568
Frequent bowel movements 13.71 11.55 9 96234 23013 63369766
Electrocardiogram T wave amplitude decreased 13.64 11.55 8 96235 371 63392408
Limb discomfort 13.56 11.55 15 96228 29701 63363078
Schizophreniform disorder 13.54 11.55 5 96238 78 63392701
Hypoglycaemia 13.54 11.55 145 96098 59920 63332859
Gamma-glutamyltransferase increased 13.40 11.55 93 96150 33938 63358841
Head injury 13.34 11.55 79 96164 27317 63365462
Hyporesponsive to stimuli 13.31 11.55 12 96231 1092 63391687
Retinal exudates 13.29 11.55 10 96233 706 63392073
Electrocardiogram T wave inversion 13.28 11.55 21 96222 3460 63389319
Respiratory failure 13.28 11.55 95 96148 101763 63291016
Candida infection 13.28 11.55 14 96229 28337 63364442
Procedural complication 13.28 11.55 27 96216 5412 63387367
Macroprolactinaemia 13.19 11.55 3 96240 6 63392773
Throat tightness 13.17 11.55 11 96232 24876 63367903
Pressure of speech 13.17 11.55 10 96233 716 63392063
Arrhythmia 13.17 11.55 101 96142 38039 63354740
Device breakage 13.17 11.55 43 96200 11499 63381280
Blood glucose 13.13 11.55 4 96239 33 63392746
Polyserositis 13.12 11.55 8 96235 399 63392380
Chronic kidney disease 13.10 11.55 31 96212 45367 63347412
Tooth disorder 13.08 11.55 14 96229 28143 63364636
Product packaging quantity issue 13.01 11.55 13 96230 1346 63391433
Eye pruritus 13.00 11.55 6 96237 18665 63374114
Pupillary light reflex tests abnormal 12.95 11.55 6 96237 170 63392609
Laboratory test abnormal 12.93 11.55 13 96230 26899 63365880
Abortion threatened 12.93 11.55 9 96234 563 63392216
Drug ineffective 12.83 11.55 1388 94855 1043377 62349402
Brief psychotic disorder, with postpartum onset 12.82 11.55 4 96239 36 63392743
Cerebrovascular stenosis 12.82 11.55 4 96239 36 63392743
Retinal vein occlusion 12.76 11.55 16 96227 2127 63390652
Palatal swelling 12.73 11.55 5 96238 93 63392686
COVID-19 pneumonia 12.63 11.55 3 96240 14206 63378573
Epileptic psychosis 12.63 11.55 4 96239 38 63392741
Sacroiliac joint dysfunction 12.63 11.55 4 96239 38 63392741
Regressive behaviour 12.60 11.55 6 96237 181 63392598
Antidepressant drug level above therapeutic 12.59 11.55 8 96235 429 63392350
Electrocardiogram U wave present 12.58 11.55 5 96238 96 63392683
Hypotensive crisis 12.53 11.55 4 96239 39 63392740
Intestinal obstruction 12.50 11.55 85 96158 30814 63361965
Hyponatraemic seizure 12.49 11.55 8 96235 435 63392344
Verbal abuse 12.49 11.55 5 96238 98 63392681
Orthostatic intolerance 12.48 11.55 12 96231 1185 63391594
Vasculitis 12.45 11.55 6 96237 18203 63374576
Product packaging issue 12.41 11.55 12 96231 1194 63391585
Deep vein thrombosis 12.36 11.55 187 96056 83613 63309166
Joint injury 12.35 11.55 16 96227 29556 63363223
Skin disorder 12.29 11.55 16 96227 29491 63363288
Road traffic accident 12.26 11.55 23 96220 36609 63356170
Frostbite 12.26 11.55 5 96238 103 63392676
Ventricular septal defect 12.23 11.55 23 96220 4355 63388424
Drug ineffective for unapproved indication 12.21 11.55 91 96152 33972 63358807
Paraesthesia oral 12.20 11.55 7 96236 19249 63373530
Delirium tremens 12.17 11.55 5 96238 105 63392674
Colour blindness 12.15 11.55 7 96236 314 63392465
Sitting disability 12.09 11.55 7 96236 317 63392462
Flight of ideas 12.00 11.55 8 96235 466 63392313
Gastric lavage 11.94 11.55 4 96239 46 63392733
Toxic encephalopathy 11.93 11.55 29 96214 6550 63386229
Subileus 11.89 11.55 19 96224 3160 63389619
Hepatic cirrhosis 11.83 11.55 12 96231 24722 63368057
Nightmare 11.81 11.55 59 96184 19135 63373644
Muscle twitching 11.78 11.55 60 96183 19608 63373171
Somnolence neonatal 11.75 11.55 5 96238 115 63392664
Product monitoring error 11.72 11.55 23 96220 4493 63388286
Spinal stenosis 11.70 11.55 4 96239 14921 63377858
Snoring 11.64 11.55 22 96221 4180 63388599
Insomnia 11.62 11.55 417 95826 214835 63177944
Posturing 11.58 11.55 8 96235 494 63392285
Drug tolerance decreased 11.58 11.55 6 96237 17467 63375312
Blood pressure systolic abnormal 11.56 11.55 3 96240 13383 63379396

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gynaecomastia 3595.01 13.03 1299 104886 8881 34841865
Extrapyramidal disorder 1914.56 13.03 884 105301 11996 34838750
Neuroleptic malignant syndrome 1617.63 13.03 877 105308 17057 34833689
Aggression 1045.03 13.03 899 105286 38065 34812681
Dystonia 1043.83 13.03 554 105631 10291 34840455
Psychotic disorder 1035.23 13.03 739 105446 23713 34827033
Sedation 952.17 13.03 662 105523 20344 34830402
Suicide attempt 838.98 13.03 796 105389 38320 34812426
Hyperprolactinaemia 832.62 13.03 273 105912 1323 34849423
Treatment noncompliance 811.97 13.03 677 105508 27423 34823323
Akathisia 807.96 13.03 424 105761 7685 34843061
Emotional disorder 761.52 13.03 364 105821 5352 34845394
Weight increased 730.50 13.03 1136 105049 91897 34758849
Tardive dyskinesia 664.39 13.03 333 105852 5457 34845289
Hallucination, auditory 648.86 13.03 421 105764 11496 34839250
Blood prolactin increased 625.76 13.03 226 105959 1534 34849212
Parkinsonism 573.82 13.03 339 105846 7799 34842947
Somnolence 541.04 13.03 1101 105084 110015 34740731
Intentional self-injury 534.30 13.03 395 105790 13376 34837370
Catatonia 532.79 13.03 274 105911 4751 34845995
Emotional distress 499.33 13.03 393 105792 14633 34836113
Priapism 485.70 13.03 257 105928 4737 34846009
Agitation 472.57 13.03 717 105468 56682 34794064
Dyskinesia 472.40 13.03 452 105733 21961 34828785
Intentional overdose 442.19 13.03 602 105583 43072 34807674
Salivary hypersecretion 437.97 13.03 292 105893 8352 34842394
Delusion 436.13 13.03 338 105847 12297 34838449
Device malfunction 417.96 13.03 305 105880 10116 34840630
Obesity 415.38 13.03 331 105854 12547 34838199
Product dose omission issue 414.44 13.03 1036 105149 118675 34732071
Muscle rigidity 408.67 13.03 302 105883 10216 34840530
Paranoia 408.21 13.03 319 105866 11749 34838997
Suicidal ideation 407.78 13.03 556 105629 39832 34810914
Abnormal behaviour 396.01 13.03 432 105753 24537 34826209
Diarrhoea 378.92 13.03 377 105808 389535 34461211
Drug interaction 369.40 13.03 1509 104676 224437 34626309
Galactorrhoea 352.27 13.03 105 106080 345 34850401
Abnormal weight gain 349.78 13.03 128 106057 906 34849840
Increased appetite 333.73 13.03 233 105952 7196 34843550
Oculogyric crisis 333.25 13.03 139 106046 1447 34849299
Device leakage 313.68 13.03 214 105971 6361 34844385
Obsessive-compulsive disorder 306.31 13.03 198 105987 5366 34845380
Schizophrenia 301.60 13.03 233 105952 8433 34842313
Febrile neutropenia 289.87 13.03 37 106148 136812 34713934
Blood creatine phosphokinase increased 288.22 13.03 501 105684 44356 34806390
Syringe issue 286.10 13.03 191 105994 5473 34845273
Psychiatric decompensation 285.17 13.03 151 106034 2786 34847960
Blood prolactin abnormal 276.88 13.03 106 106079 863 34849883
Sexual dysfunction 269.92 13.03 192 105993 6111 34844635
Arthralgia 266.64 13.03 92 106093 169949 34680797
Psychotic symptom 266.12 13.03 122 106063 1621 34849125
Nausea 261.83 13.03 393 105792 339515 34511231
Dyspnoea 255.69 13.03 473 105712 376309 34474437
Restlessness 234.99 13.03 336 105849 25146 34825600
Rash 230.30 13.03 203 105982 222549 34628197
Tic 223.29 13.03 114 106071 1944 34848802
Pneumonia 219.65 13.03 486 105699 362141 34488605
Psychomotor hyperactivity 214.01 13.03 200 105985 9422 34841324
Rhabdomyolysis 211.85 13.03 567 105618 67596 34783150
Pleurothotonus 211.56 13.03 93 106092 1112 34849634
Psychomotor skills impaired 210.10 13.03 137 106048 3769 34846977
Tachycardia 209.16 13.03 649 105536 84123 34766623
Anxiety 206.61 13.03 718 105467 98710 34752036
Tearfulness 206.24 13.03 118 106067 2549 34848197
Disinhibition 205.66 13.03 126 106059 3100 34847646
Depressive symptom 193.42 13.03 116 106069 2743 34848003
Antipsychotic drug level below therapeutic 192.44 13.03 111 106074 2436 34848310
Disturbance in social behaviour 187.76 13.03 98 106087 1753 34848993
Anaemia 181.05 13.03 268 105917 233067 34617679
Irritability 180.13 13.03 292 105893 24398 34826348
Malignant neoplasm progression 176.53 13.03 28 106157 88018 34762728
Hypothermia 173.89 13.03 188 105997 10560 34840186
Anosognosia 173.76 13.03 76 106109 897 34849849
Mania 171.02 13.03 176 106009 9335 34841411
Coma 170.08 13.03 407 105778 45271 34805475
Psychomotor retardation 169.84 13.03 117 106068 3533 34847213
Depressed level of consciousness 169.61 13.03 391 105794 42450 34808296
Depression suicidal 167.81 13.03 101 106084 2404 34848342
Sopor 165.14 13.03 194 105991 11942 34838804
Euphoric mood 165.01 13.03 137 106048 5504 34845242
Emotional poverty 162.25 13.03 63 106122 535 34850211
Cogwheel rigidity 161.68 13.03 80 106105 1272 34849474
Back pain 158.85 13.03 86 106099 121703 34729043
Asthenia 157.98 13.03 317 105868 244934 34605812
Sepsis 157.74 13.03 164 106021 166397 34684349
Pain 154.92 13.03 239 105946 204436 34646310
Death 154.67 13.03 654 105531 397395 34453351
Pain in extremity 152.77 13.03 98 106087 126415 34724331
Pruritus 151.92 13.03 125 106060 141856 34708890
Product use in unapproved indication 148.49 13.03 728 105457 116771 34733975
Fatigue 142.69 13.03 611 105574 370042 34480704
Persecutory delusion 137.56 13.03 90 106095 2490 34848256
Therapeutic product effect variable 136.65 13.03 88 106097 2368 34848378
Oromandibular dystonia 133.16 13.03 52 106133 449 34850297
Serotonin syndrome 132.34 13.03 226 105959 19707 34831039
Overdose 131.74 13.03 587 105598 90472 34760274
Disease progression 131.45 13.03 83 106102 107994 34742752
Cough 129.94 13.03 159 106026 149981 34700765
Cardiac failure congestive 127.04 13.03 47 106138 83223 34767523
Foreign body 126.80 13.03 63 106122 1011 34849735
Atrial fibrillation 125.72 13.03 112 106073 122281 34728465
Apathy 124.13 13.03 128 106057 6804 34843942
Acute kidney injury 122.06 13.03 495 105690 304493 34546253
Delirium 118.93 13.03 348 105837 43643 34807103
Metabolic disorder 114.96 13.03 99 106086 4184 34846562
Hallucination 113.94 13.03 380 105805 51118 34799628
Peripheral swelling 113.77 13.03 45 106140 76496 34774250
Mental impairment 111.55 13.03 147 106038 10175 34840571
Insomnia 109.29 13.03 612 105573 103295 34747451
Infusion related reaction 108.31 13.03 16 106169 53041 34797705
Tremor 108.06 13.03 517 105668 82070 34768676
Speech disorder 107.82 13.03 240 105945 25446 34825300
Nasopharyngitis 107.55 13.03 39 106146 69929 34780817
Medication error 107.46 13.03 239 105946 25326 34825420
Sedation complication 107.17 13.03 67 106118 1710 34849036
Haemoglobin decreased 106.48 13.03 126 106059 120646 34730100
Homicidal ideation 106.38 13.03 78 106107 2604 34848142
Diabetes mellitus 105.59 13.03 348 105837 46525 34804221
Neuropathy peripheral 105.34 13.03 61 106124 83202 34767544
Drooling 102.81 13.03 84 106101 3298 34847448
Product reconstitution quality issue 101.95 13.03 30 106155 93 34850653
Needle issue 101.76 13.03 109 106076 6056 34844690
Joint swelling 101.64 13.03 28 106157 59862 34790884
Dyspnoea exertional 101.14 13.03 8 106177 43271 34807475
Product administration error 100.29 13.03 179 106006 16165 34834581
Electrocardiogram QT prolonged 99.46 13.03 312 105873 40640 34810106
Psychiatric symptom 97.95 13.03 83 106102 3430 34847316
Drug hypersensitivity 97.67 13.03 62 106123 80467 34770279
Urinary incontinence 96.27 13.03 191 105994 18683 34832063
Septic shock 94.67 13.03 50 106135 71784 34778962
Withdrawal syndrome 94.51 13.03 150 106035 12305 34838441
Underdose 93.80 13.03 158 106027 13622 34837124
Disturbance in attention 93.12 13.03 228 105957 25717 34825029
Myocarditis 91.97 13.03 156 106029 13526 34837220
Social avoidant behaviour 91.85 13.03 76 106109 3038 34847708
Abdominal pain 91.68 13.03 228 105957 163390 34687356
Prostate cancer 90.80 13.03 8 106177 39641 34811105
Polydipsia 90.18 13.03 83 106102 3832 34846914
Product quality issue 90.05 13.03 175 106010 16860 34833886
Acute myocardial infarction 89.51 13.03 26 106159 53693 34797053
Decreased appetite 89.28 13.03 237 105948 166155 34684591
Device breakage 89.22 13.03 66 106119 2234 34848512
Refusal of treatment by patient 88.44 13.03 92 106093 4940 34845806
Headache 88.30 13.03 313 105872 200322 34650424
Delusional disorder, persecutory type 88.25 13.03 34 106151 282 34850464
Sluggishness 87.66 13.03 76 106109 3241 34847505
Interstitial lung disease 86.67 13.03 45 106140 65237 34785509
Torticollis 86.40 13.03 50 106135 1104 34849642
Breast enlargement 86.17 13.03 38 106147 458 34850288
Delusion of grandeur 86.16 13.03 50 106135 1110 34849636
Erythema 85.55 13.03 86 106099 88694 34762052
Opisthotonus 85.09 13.03 37 106148 430 34850316
Rheumatoid arthritis 84.19 13.03 9 106176 38229 34812517
Seizure 82.89 13.03 574 105611 104283 34746463
Pyrexia 82.50 13.03 633 105552 332380 34518366
Cognitive disorder 82.39 13.03 232 105953 28461 34822285
Thinking abnormal 81.65 13.03 97 106088 6040 34844706
Malignant catatonia 81.53 13.03 30 106155 216 34850530
Intrusive thoughts 81.28 13.03 32 106153 283 34850463
Hallucination, visual 81.24 13.03 172 106013 17619 34833127
Chills 80.99 13.03 76 106109 80967 34769779
Gastrointestinal haemorrhage 80.45 13.03 90 106095 88387 34762359
Pneumonia aspiration 80.38 13.03 295 105890 41608 34809138
Hyperthermia 79.73 13.03 127 106058 10450 34840296
Chest discomfort 79.48 13.03 33 106152 54497 34796249
Thrombosis 79.46 13.03 27 106158 50431 34800315
Dysarthria 79 13.03 259 105926 34523 34816223
Wrong product administered 78.84 13.03 89 106096 5245 34845501
Hospitalisation 78.62 13.03 362 105823 56540 34794206
Dyslipidaemia 78.39 13.03 105 106080 7383 34843363
Incorrect dose administered 78.36 13.03 286 105899 40229 34810517
Confusional state 78.32 13.03 724 105461 143436 34707310
Accidental exposure to product 78.27 13.03 140 106045 12662 34838084
Stomatitis 77.73 13.03 17 106168 42497 34808249
Schizoaffective disorder 77.43 13.03 49 106136 1278 34849468
Blunted affect 77.14 13.03 32 106153 328 34850418
Enuresis 76.95 13.03 61 106124 2292 34848454
Ascites 76.75 13.03 23 106162 46548 34804198
Polydipsia psychogenic 76.67 13.03 24 106161 97 34850649
Mutism 75.70 13.03 42 106143 853 34849893
Myocardial infarction 75.67 13.03 159 106026 120926 34729820
Metabolic syndrome 75.62 13.03 53 106132 1646 34849100
Type 2 diabetes mellitus 75.54 13.03 157 106028 15875 34834871
Blood triglycerides increased 75.50 13.03 146 106039 14013 34836733
Water intoxication 75.03 13.03 33 106152 395 34850351
Behaviour disorder 74.41 13.03 83 106102 4827 34845919
Paraesthesia 74.31 13.03 52 106133 64120 34786626
Oedema peripheral 74.31 13.03 158 106027 119654 34731092
Productive cough 73.59 13.03 13 106172 37800 34812946
Drug ineffective 73.11 13.03 1858 104327 454893 34395853
Soliloquy 71.88 13.03 32 106153 395 34850351
Infection 69.76 13.03 105 106080 90810 34759936
Oropharyngeal spasm 69.07 13.03 24 106161 143 34850603
Intentional product use issue 68.56 13.03 49 106136 59767 34790979
Overweight 68.34 13.03 52 106133 1838 34848908
Completed suicide 68.15 13.03 521 105664 97647 34753099
Abdominal pain upper 68.01 13.03 70 106115 71420 34779326
Plasma cell myeloma 67.06 13.03 22 106163 42015 34808731
Personality change 66.36 13.03 80 106105 5059 34845687
Psoriasis 66.11 13.03 18 106167 38794 34811952
COVID-19 66.09 13.03 83 106102 77467 34773279
Staring 65.76 13.03 46 106139 1424 34849322
Cerebrovascular accident 65.02 13.03 98 106087 84713 34766033
Pancytopenia 64.58 13.03 119 106066 95038 34755708
Coronary artery disease 64.55 13.03 33 106152 48272 34802474
Leukopenia 63.89 13.03 367 105818 62489 34788257
Hyperkalaemia 63.71 13.03 70 106115 69319 34781427
Anger 62.70 13.03 122 106063 11762 34838984
Sinusitis 62.06 13.03 24 106161 41378 34809368
Hypertonia 61.32 13.03 70 106115 4176 34846570
Pneumonitis 61.02 13.03 14 106171 33864 34816882
Myalgia 60.87 13.03 101 106084 84009 34766737
Systemic infection 60.65 13.03 77 106108 5135 34845611
Arthritis 60.51 13.03 11 106174 31335 34819411
Suicidal behaviour 60.42 13.03 44 106141 1453 34849293
Blood pressure increased 59.94 13.03 110 106075 87992 34762754
Colitis 59.79 13.03 20 106165 37730 34813016
Rebound effect 59.60 13.03 61 106124 3213 34847533
Inappropriate affect 59.49 13.03 33 106152 670 34850076
Gaze palsy 59.48 13.03 46 106139 1666 34849080
Sudden death 59.30 13.03 138 106047 15063 34835683
Conduction disorder 59.13 13.03 50 106135 2060 34848686
Malaise 58.67 13.03 328 105857 185497 34665249
Urticaria 58.29 13.03 62 106123 62315 34788431
Spasmodic dysphonia 58.07 13.03 23 106162 207 34850539
Diet refusal 57.92 13.03 25 106160 285 34850461
Psychosexual disorder 57.77 13.03 19 106166 93 34850653
Protrusion tongue 57.68 13.03 22 106163 177 34850569
Cytokine release syndrome 57.08 13.03 3 106182 22874 34827872
Epilepsy 57.07 13.03 169 106016 21326 34829420
Chest pain 56.87 13.03 196 105989 126566 34724180
Erectile dysfunction 56.46 13.03 164 106021 20473 34830273
Blood creatinine increased 55.79 13.03 129 106056 94847 34755899
Breast discharge 54.96 13.03 15 106170 32 34850714
Antipsychotic drug level increased 54.60 13.03 63 106122 3802 34846944
Epistaxis 54.32 13.03 58 106127 58193 34792553
Respiratory failure 53.48 13.03 161 106024 108411 34742335
Muscle spasms 53.40 13.03 91 106094 74910 34775836
Herpes zoster 53.14 13.03 19 106166 34380 34816366
Eye movement disorder 52.89 13.03 64 106121 4063 34846683
Cardiac failure 52.74 13.03 125 106060 91123 34759623
Adverse event 52.59 13.03 151 106034 18726 34832020
Bradykinesia 52.56 13.03 62 106123 3831 34846915
Incoherent 52.16 13.03 66 106119 4386 34846360
Obsessive thoughts 52.02 13.03 31 106154 724 34850022
Dizziness 51.83 13.03 420 105765 218101 34632645
Multiple organ dysfunction syndrome 51.72 13.03 96 106089 76470 34774276
Affective disorder 51.66 13.03 65 106120 4295 34846451
Weight decreased 51.49 13.03 319 105866 175982 34674764
Sinus tachycardia 51.43 13.03 142 106043 17218 34833528
Hypometabolism 51.42 13.03 18 106167 110 34850636
Stupor 51.07 13.03 53 106132 2838 34847908
Major depression 50.77 13.03 66 106119 4506 34846240
Eosinophilic pneumonia acute 50.08 13.03 27 106158 517 34850229
Hypoaesthesia 50.05 13.03 68 106117 61376 34789370
Prescribed overdose 49.84 13.03 104 106081 10543 34840203
Compulsive sexual behaviour 49.40 13.03 21 106164 230 34850516
Vomiting 49.12 13.03 498 105687 247123 34603623
Melaena 49.04 13.03 23 106162 35357 34815389
Diabetic coma 48.91 13.03 32 106153 885 34849861
Posture abnormal 48.74 13.03 46 106139 2193 34848553
Anticholinergic syndrome 48.29 13.03 36 106149 1233 34849513
Psoriatic arthropathy 48.16 13.03 3 106182 19795 34830951
Floppy iris syndrome 47.80 13.03 22 106163 295 34850451
International normalised ratio increased 47.71 13.03 44 106141 47283 34803463
Pleural effusion 47.69 13.03 111 106074 81435 34769311
Hyperammonaemic encephalopathy 47.28 13.03 46 106139 2278 34848468
Hypersensitivity 47.28 13.03 70 106115 60965 34789781
Blepharospasm 47.19 13.03 34 106151 1104 34849642
Illusion 46.92 13.03 30 106155 797 34849949
Hostility 46.23 13.03 30 106155 818 34849928
Wheezing 46.04 13.03 35 106150 41367 34809379
Flat affect 45.72 13.03 30 106155 834 34849912
Wrong patient received product 45.71 13.03 48 106137 2606 34848140
Product container issue 45.62 13.03 28 106157 691 34850055
Altered state of consciousness 45.43 13.03 163 106022 22730 34828016
Off label use 45.42 13.03 1627 104558 417897 34432849
Paroxysmal perceptual alteration 45.38 13.03 10 106175 3 34850743
Impaired self-care 45.37 13.03 35 106150 1263 34849483
Parkinsonian gait 45.36 13.03 25 106160 501 34850245
Chronic obstructive pulmonary disease 45.28 13.03 49 106136 48869 34801877
Bacteraemia 45.08 13.03 4 106181 19713 34831033
Condition aggravated 45.07 13.03 827 105358 191369 34659377
Anaphylactic reaction 44.77 13.03 21 106164 32280 34818466
Rabbit syndrome 44.72 13.03 11 106174 12 34850734
Grandiosity 44.01 13.03 21 106164 307 34850439
Hypoxia 43.84 13.03 62 106123 55033 34795713
Ideas of reference 43.77 13.03 13 106172 42 34850704
Haemoptysis 43.74 13.03 26 106159 34980 34815766
Hypomagnesaemia 43.65 13.03 7 106178 21844 34828902
Cerebral haemorrhage 43.59 13.03 26 106159 34911 34815835
Miosis 43.31 13.03 92 106093 9443 34841303
Diverticulitis 43.29 13.03 5 106180 19999 34830747
Swelling 43.17 13.03 39 106146 42327 34808419
Hypersexuality 43.12 13.03 36 106149 1457 34849289
Dysphemia 43.07 13.03 37 106148 1558 34849188
Staphylococcal infection 42.85 13.03 23 106162 32737 34818009
Physical assault 42.50 13.03 32 106153 1113 34849633
Platelet count decreased 42.43 13.03 203 105982 119514 34731232
Thrombocytopenia 42.41 13.03 289 105896 155958 34694788
Illness anxiety disorder 42.25 13.03 17 106168 160 34850586
Abdominal discomfort 42.22 13.03 73 106112 59762 34790984
Waxy flexibility 42.14 13.03 15 106170 97 34850649
Product substitution issue 41.98 13.03 94 106091 10001 34840745
Type 1 diabetes mellitus 41.98 13.03 58 106127 4200 34846546
Cellulitis 41.73 13.03 60 106125 52891 34797855
Choking 41.68 13.03 63 106122 4952 34845794
Fluid retention 41.27 13.03 15 106170 26872 34823874
Depressed mood 40.45 13.03 140 106045 19177 34831569
Product physical issue 40.31 13.03 44 106141 2497 34848249
Lymphadenopathy 40.23 13.03 18 106167 28445 34822301
Logorrhoea 40.22 13.03 43 106142 2383 34848363
Basal cell carcinoma 39.94 13.03 6 106179 19652 34831094
Mental disorder 39.82 13.03 119 106066 15090 34835656
Tachyphrenia 39.59 13.03 32 106153 1237 34849509
Upper gastrointestinal haemorrhage 39.57 13.03 14 106171 25504 34825242
Haematochezia 39.43 13.03 50 106135 46484 34804262
Influenza 39.41 13.03 56 106129 49610 34801136
Painful erection 39.40 13.03 18 106167 237 34850509
Tourette's disorder 39.30 13.03 13 106172 65 34850681
Homosexuality 39.25 13.03 12 106173 44 34850702
Screaming 39.21 13.03 34 106151 1450 34849296
Blood pressure fluctuation 38.90 13.03 14 106171 25235 34825511
Myelosuppression 38.87 13.03 6 106179 19259 34831487
Gout 38.83 13.03 6 106179 19247 34831499
Mucosal inflammation 38.82 13.03 36 106149 38586 34812160
Haemorrhage 38.74 13.03 60 106125 51310 34799436
Asthma 38.08 13.03 44 106141 42612 34808134
Hypervolaemia 37.86 13.03 7 106178 19702 34831044
Granulocytopenia 37.84 13.03 70 106115 6497 34844249
Self-injurious ideation 37.43 13.03 35 106150 1649 34849097
Dementia 37.36 13.03 109 106076 13639 34837107
Chronic kidney disease 37.35 13.03 42 106143 41168 34809578
Nephrolithiasis 37.24 13.03 23 106162 30310 34820436
Hypotonia 37.10 13.03 77 106108 7776 34842970
Palmar-plantar erythrodysaesthesia syndrome 36.84 13.03 4 106181 16791 34833955
Wrong technique in product usage process 36.47 13.03 210 105975 35776 34814970
Osteoarthritis 36.25 13.03 9 106176 20633 34830113
Lower respiratory tract infection 36.13 13.03 26 106159 31611 34819135
Toxicity to various agents 35.72 13.03 828 105357 199534 34651212
Clostridium difficile infection 35.69 13.03 7 106178 18891 34831855
Dysgeusia 35.55 13.03 18 106167 26479 34824267
Obsessive-compulsive symptom 35.54 13.03 14 106171 124 34850622
Angina pectoris 35.53 13.03 26 106159 31337 34819409
Feeling guilty 35.35 13.03 18 106167 305 34850441
Sexually inappropriate behaviour 35.22 13.03 21 106164 491 34850255
Schizophreniform disorder 35.04 13.03 12 106173 68 34850678
Arthropathy 35.03 13.03 19 106166 26888 34823858
Rebound psychosis 34.83 13.03 15 106170 170 34850576
Respiratory dyskinesia 34.80 13.03 9 106176 14 34850732
Acute psychosis 34.75 13.03 35 106150 1808 34848938
Hyponatraemia 34.65 13.03 394 105791 82297 34768449
Anaphylactic shock 34.46 13.03 4 106181 15937 34834809
Rectal haemorrhage 34.36 13.03 43 106142 40206 34810540
Dysphagia 34.15 13.03 314 105871 62067 34788679
Bradyphrenia 33.96 13.03 56 106129 4742 34846004
Disorientation 33.85 13.03 194 105991 32994 34817752
Pneumocystis jirovecii pneumonia 33.83 13.03 9 106176 19701 34831045
Bronchopulmonary aspergillosis 33.44 13.03 3 106182 14656 34836090
Mood swings 33.34 13.03 74 106111 7827 34842919
Incontinence 33.28 13.03 62 106123 5785 34844961
Bladder dilatation 33.14 13.03 31 106154 1461 34849285
Abdominal distension 33.09 13.03 81 106104 58411 34792335
Renal impairment 33.05 13.03 161 106024 94352 34756394
Reduced facial expression 32.95 13.03 27 106158 1064 34849682
Inappropriate schedule of product administration 32.81 13.03 311 105874 61985 34788761
Bone pain 32.68 13.03 11 106174 20675 34830071
Inappropriate antidiuretic hormone secretion 32.65 13.03 99 106086 12654 34838092
Renal failure 32.26 13.03 248 105937 130309 34720437
Wolff-Parkinson-White syndrome 31.95 13.03 15 106170 211 34850535
Device occlusion 31.89 13.03 65 106120 6480 34844266
Upper respiratory tract infection 31.85 13.03 32 106153 33027 34817719
Product label issue 31.75 13.03 16 106169 265 34850481
Adrenal insufficiency 31.71 13.03 3 106182 14044 34836702
Head titubation 31.28 13.03 18 106167 393 34850353
Oropharyngeal pain 31.25 13.03 37 106148 35448 34815298
Sinus bradycardia 30.75 13.03 98 106087 12865 34837881
Prolactin-producing pituitary tumour 30.56 13.03 9 106176 28 34850718
Laboratory test abnormal 30.26 13.03 12 106173 20379 34830367
Hyperbilirubinaemia 30.25 13.03 7 106178 16836 34833910
Hallucinations, mixed 30.14 13.03 39 106146 2650 34848096
Impulsive behaviour 30.14 13.03 35 106150 2127 34848619
Antipsychotic drug level above therapeutic 30.08 13.03 27 106158 1206 34849540
Muscular weakness 29.84 13.03 117 106068 72780 34777966
Tongue movement disturbance 29.82 13.03 12 106173 113 34850633
Libido decreased 29.53 13.03 52 106133 4644 34846102
Heart rate decreased 29.15 13.03 32 106153 31713 34819033
Paradoxical drug reaction 29.14 13.03 43 106142 3308 34847438
Bacterial infection 28.89 13.03 8 106177 17055 34833691
Visceral congestion 28.85 13.03 20 106165 610 34850136
Candida infection 28.73 13.03 9 106176 17706 34833040
Hyperkinesia 28.72 13.03 31 106154 1737 34849009
Depression 28.67 13.03 434 105751 96664 34754082
COVID-19 pneumonia 28.65 13.03 8 106177 16959 34833787
Excessive eye blinking 28.58 13.03 19 106166 540 34850206
Neutropenic sepsis 28.44 13.03 4 106181 13763 34836983
Autism spectrum disorder 28.44 13.03 35 106150 2261 34848485
Negativism 28.34 13.03 17 106168 402 34850344
Communication disorder 28.34 13.03 37 106148 2537 34848209
Dry skin 28.22 13.03 32 106153 31255 34819491
Haematuria 27.80 13.03 70 106115 49996 34800750
Neuralgia 27.71 13.03 6 106179 15107 34835639
Flatulence 27.55 13.03 15 106170 21183 34829563
Meconium aspiration syndrome 27.54 13.03 9 106176 43 34850703
Device related infection 27.52 13.03 9 106176 17228 34833518
Imprisonment 27.35 13.03 18 106167 503 34850243
Blood cholesterol increased 27.11 13.03 129 106056 20414 34830332
Tumour lysis syndrome 27.07 13.03 9 106176 17050 34833696
Pseudomonas infection 27.03 13.03 3 106182 12379 34838367
Localised infection 26.68 13.03 10 106175 17577 34833169
Generalised tonic-clonic seizure 26.53 13.03 131 106054 21043 34829703
Osteomyelitis 26.52 13.03 8 106177 16128 34834618
Hypocalcaemia 26.41 13.03 21 106164 24268 34826478
Mastication disorder 26.40 13.03 26 106159 1307 34849439
Hepatic failure 26.35 13.03 40 106145 34491 34816255
Electroencephalogram abnormal 26.32 13.03 35 106150 2443 34848303
Oral candidiasis 26.27 13.03 3 106182 12107 34838639
Night sweats 26.10 13.03 10 106175 17342 34833404
Fungal infection 26.01 13.03 8 106177 15927 34834819
Eating disorder 26.01 13.03 69 106116 8171 34842575
Neoplasm malignant 25.99 13.03 14 106171 19891 34830855
Drug screen false positive 25.99 13.03 20 106165 719 34850027
Decreased gait velocity 25.93 13.03 12 106173 163 34850583
Pulmonary mass 25.82 13.03 4 106181 12808 34837938
Skin ulcer 25.71 13.03 18 106167 22198 34828548
Lung disorder 25.70 13.03 41 106144 34655 34816091
Liquid product physical issue 25.52 13.03 17 106168 485 34850261
Neoplasm progression 25.51 13.03 20 106165 23280 34827466
Tachypnoea 25.50 13.03 117 106068 18235 34832511
Drug withdrawal syndrome neonatal 25.30 13.03 42 106143 3577 34847169
Retrograde ejaculation 25.29 13.03 16 106169 417 34850329
Bone marrow failure 25.23 13.03 31 106154 29222 34821524
Oral discharge 25.21 13.03 11 106174 129 34850617
Small intestinal obstruction 25.11 13.03 7 106178 14859 34835887
Hypomania 24.57 13.03 33 106152 2326 34848420
Posturing 24.57 13.03 17 106168 517 34850229
Dopamine dysregulation syndrome 24.54 13.03 16 106169 440 34850306
Product dispensing error 24.51 13.03 57 106128 6217 34844529
Musculoskeletal pain 24.41 13.03 37 106148 31926 34818820
Ejaculation failure 24.39 13.03 20 106165 789 34849957
Gastrointestinal disorder 24.32 13.03 41 106144 33907 34816839
Pulmonary hypertension 24.15 13.03 17 106168 20907 34829839
Transient ischaemic attack 24.09 13.03 29 106156 27584 34823162
Musculoskeletal stiffness 24.06 13.03 232 105953 46448 34804298
Exposure to contaminated device 24.00 13.03 5 106180 0 34850746
Leukaemia 23.97 13.03 47 106138 4556 34846190
Electrocardiogram abnormal 23.87 13.03 72 106113 9175 34841571
Rapid eye movement sleep behaviour disorder 23.80 13.03 11 106174 149 34850597
Dysphoria 23.66 13.03 32 106153 2270 34848476
Product packaging issue 23.66 13.03 18 106167 636 34850110
Rhinalgia 23.62 13.03 22 106163 1031 34849715
Choreoathetosis 23.43 13.03 22 106163 1042 34849704
Cytopenia 23.43 13.03 5 106180 12718 34838028
Faecaloma 23.41 13.03 51 106134 5326 34845420
Progressive supranuclear palsy 23.41 13.03 8 106177 45 34850701
Faeces discoloured 23.35 13.03 8 106177 14870 34835876
Movement disorder 23.28 13.03 86 106099 12162 34838584
Hypophosphataemia 23.26 13.03 3 106182 11023 34839723
Migraine 23.25 13.03 12 106173 17466 34833280
Inadequate diet 23.17 13.03 10 106175 114 34850632
Neuroleptic-induced deficit syndrome 23.04 13.03 7 106178 25 34850721
Keratoconus 22.94 13.03 10 106175 117 34850629
Pituitary tumour benign 22.91 13.03 20 106165 861 34849885
Ileus paralytic 22.90 13.03 54 106131 5943 34844803
Facial spasm 22.87 13.03 12 106173 217 34850529
Arteriosclerosis coronary artery 22.80 13.03 5 106180 12480 34838266
Impaired healing 22.79 13.03 9 106176 15325 34835421
Grimacing 22.75 13.03 13 106172 280 34850466
Oral pain 22.71 13.03 3 106182 10824 34839922
Angina unstable 22.68 13.03 4 106181 11649 34839097
Flushing 22.46 13.03 40 106145 32380 34818366
Benign prostatic hyperplasia 22.39 13.03 8 106177 14487 34836259
Bruxism 22.38 13.03 27 106158 1708 34849038
Blood pressure systolic increased 22.35 13.03 22 106163 22930 34827816
Rhinorrhoea 22.35 13.03 27 106158 25641 34825105
Arachnoid cyst 22.34 13.03 12 106173 228 34850518
Diabetic hyperosmolar coma 22.33 13.03 15 106170 434 34850312
Pulmonary oedema 22.31 13.03 72 106113 47457 34803289
Bronchitis 22.28 13.03 60 106125 41903 34808843
Flight of ideas 22.20 13.03 14 106171 363 34850383
Blister 22.16 13.03 22 106163 22836 34827910
Self esteem decreased 22.11 13.03 16 106169 523 34850223
Brain injury 22.05 13.03 54 106131 6088 34844658
Circadian rhythm sleep disorder 22.03 13.03 15 106170 444 34850302
Drug abuse 22.00 13.03 423 105762 98673 34752073
Product packaging quantity issue 21.99 13.03 20 106165 909 34849837
Respiratory muscle weakness 21.98 13.03 9 106176 89 34850657
Prader-Willi syndrome 21.92 13.03 6 106179 13 34850733
Delusional disorder, unspecified type 21.80 13.03 18 106167 717 34850029
Hot flush 21.76 13.03 14 106171 18052 34832694
Oedema 21.67 13.03 69 106116 45672 34805074
Frequent bowel movements 21.64 13.03 6 106179 12781 34837965
Deafness 21.64 13.03 4 106181 11261 34839485
Drug withdrawal syndrome 21.59 13.03 118 106067 19716 34831030
Aptyalism 21.44 13.03 14 106171 386 34850360
Hyponatraemic syndrome 21.42 13.03 11 106174 190 34850556
Heat stroke 21.34 13.03 20 106165 945 34849801
Stereotypy 21.32 13.03 18 106167 740 34850006
Myoclonus 21.30 13.03 95 106090 14630 34836116
Flashback 21.22 13.03 10 106175 142 34850604
Tobacco user 21.19 13.03 16 106169 559 34850187
Dehydration 21.16 13.03 273 105912 129696 34721050
Loss of libido 21.12 13.03 32 106153 2520 34848226
Bipolar disorder 21.00 13.03 39 106146 3630 34847116
Renal disorder 20.94 13.03 28 106157 25452 34825294
Lymphoma 20.92 13.03 6 106179 12501 34838245
Coronary artery occlusion 20.83 13.03 4 106181 10958 34839788
Cerebral atrophy 20.76 13.03 44 106141 4508 34846238
Substance-induced psychotic disorder 20.73 13.03 26 106159 1712 34849034
Skin exfoliation 20.71 13.03 32 106153 27400 34823346
Derealisation 20.65 13.03 16 106169 581 34850165
Clostridium difficile colitis 20.63 13.03 11 106174 15719 34835027
Ejaculation disorder 20.58 13.03 20 106165 989 34849757
Infertility 20.53 13.03 11 106174 208 34850538
Selective mutism 20.49 13.03 8 106177 69 34850677
Crying 20.48 13.03 51 106134 5811 34844935
Skin lesion 20.31 13.03 22 106163 21939 34828807
Intervertebral disc protrusion 20.31 13.03 3 106182 9953 34840793
Hepatitis C virus test positive 20.31 13.03 13 106172 346 34850400
Posterior reversible encephalopathy syndrome 20.31 13.03 3 106182 9951 34840795
Procedural complication 20.24 13.03 42 106143 4241 34846505
Colitis ischaemic 20.21 13.03 54 106131 6421 34844325
Erection increased 20.17 13.03 15 106170 512 34850234
Dementia with Lewy bodies 20.15 13.03 17 106168 698 34850048
Lung infiltration 20.15 13.03 7 106178 12898 34837848
Sarcopenia 20.11 13.03 14 106171 430 34850316
White blood cell count decreased 20.10 13.03 189 105996 95256 34755490
Self esteem inflated 20.08 13.03 5 106180 6 34850740
Accidental overdose 20.06 13.03 117 106068 20023 34830723
Corneal reflex decreased 19.99 13.03 10 106175 163 34850583
Gender dysphoria 19.83 13.03 7 106178 44 34850702
Graft versus host disease 19.78 13.03 4 106181 10565 34840181
Sinus arrhythmia 19.65 13.03 18 106167 826 34849920
Multiple drug therapy 19.63 13.03 14 106171 447 34850299
Acute myeloid leukaemia 19.60 13.03 16 106169 18254 34832492
Borderline personality disorder 19.33 13.03 13 106172 377 34850369
Poisoning 19.31 13.03 81 106104 12145 34838601
Muscle twitching 19.31 13.03 72 106113 10226 34840520
Portal vein cavernous transformation 19.20 13.03 4 106181 0 34850746
Proteinuria 19.18 13.03 17 106168 18625 34832121
Pulmonary haemorrhage 19.07 13.03 4 106181 10300 34840446
Cyclothymic disorder 19.03 13.03 8 106177 85 34850661
Lung neoplasm malignant 18.96 13.03 15 106170 17380 34833366
Rash pruritic 18.88 13.03 33 106152 26908 34823838
Visual acuity reduced 18.80 13.03 13 106172 16136 34834610
Myopathy toxic 18.75 13.03 15 106170 571 34850175
Pressure of speech 18.74 13.03 14 106171 481 34850265
Osteonecrosis 18.68 13.03 11 106174 14879 34835867
Neutrophil count increased 18.65 13.03 102 106083 17044 34833702
Enterococcal infection 18.54 13.03 3 106182 9303 34841443
Suspiciousness 18.50 13.03 12 106173 327 34850419
Appendicitis 18.49 13.03 11 106174 14796 34835950
Poriomania 18.47 13.03 8 106177 92 34850654
Hallucination, olfactory 18.34 13.03 10 106175 196 34850550
Product complaint 18.26 13.03 49 106136 5841 34844905
Boredom 18.14 13.03 6 106179 30 34850716
Tendonitis 18.09 13.03 3 106182 9137 34841609
Post procedural complication 18.09 13.03 6 106179 11382 34839364
Myelodysplastic syndrome 18.04 13.03 19 106166 19189 34831557
Shock haemorrhagic 18.00 13.03 6 106179 11348 34839398
Meningeal disorder 17.87 13.03 12 106173 347 34850399
Hypoacusis 17.84 13.03 14 106171 16287 34834459
Inflammation 17.78 13.03 37 106148 28258 34822488
Laryngeal dyspnoea 17.74 13.03 8 106177 102 34850644
Skin pressure mark 17.67 13.03 7 106178 63 34850683
Slow speech 17.67 13.03 20 106165 1182 34849564
Breast disorder 17.63 13.03 5 106180 13 34850733
Pulmonary fibrosis 17.50 13.03 18 106167 18378 34832368
Accidental exposure to product by child 17.48 13.03 22 106163 1454 34849292
Influenza like illness 17.47 13.03 36 106149 27598 34823148
Tubulointerstitial nephritis 17.38 13.03 23 106162 21001 34829745
Feeling hot 17.27 13.03 20 106165 19352 34831394
Blood glucose fluctuation 17.20 13.03 38 106147 4006 34846740
Hernia 17.17 13.03 4 106181 9579 34841167
Acute respiratory distress syndrome 17.14 13.03 33 106152 25936 34824810
Skin cancer 17.11 13.03 5 106180 10292 34840454
Autonomic nervous system imbalance 17.02 13.03 29 106156 2522 34848224
Hunger 17.01 13.03 23 106162 1631 34849115
Delusional perception 16.99 13.03 9 106176 166 34850580
Illness 16.97 13.03 10 106175 13519 34837227
Attention deficit hyperactivity disorder 16.96 13.03 29 106156 2530 34848216
Dextrocardia 16.95 13.03 8 106177 114 34850632
C-reactive protein abnormal 16.93 13.03 3 106182 8707 34842039
Somatic dysfunction 16.87 13.03 5 106180 16 34850730
Compulsions 16.84 13.03 10 106175 232 34850514
Gastrooesophageal reflux disease 16.74 13.03 59 106126 37865 34812881
Squamous cell carcinoma 16.62 13.03 7 106178 11468 34839278
Paraphilia 16.60 13.03 7 106178 75 34850671
Alcohol abuse 16.59 13.03 41 106144 4649 34846097
Hyperphagia 16.52 13.03 21 106164 1402 34849344
Antisocial behaviour 16.51 13.03 12 106173 395 34850351
Asphyxia 16.51 13.03 52 106133 6783 34843963
Ventricular tachycardia 16.49 13.03 35 106150 26544 34824202
Exhibitionism 16.45 13.03 6 106179 42 34850704
Frontotemporal dementia 16.43 13.03 10 106175 243 34850503
Discomfort 16.40 13.03 20 106165 18918 34831828
Subarachnoid haemorrhage 16.33 13.03 9 106176 12626 34838120
Feminisation acquired 16.33 13.03 6 106179 43 34850703
Urinary tract infection 16.24 13.03 170 106015 83911 34766835
Vascular stenosis 16.21 13.03 9 106176 183 34850563
Product prescribing issue 16.19 13.03 26 106159 2153 34848593
Trismus 16.17 13.03 28 106157 2467 34848279
Acarodermatitis 16.15 13.03 12 106173 409 34850337
Hip fracture 16.15 13.03 8 106177 11917 34838829
Therapeutic product effect incomplete 16.12 13.03 229 105956 50312 34800434
Throat irritation 16.08 13.03 6 106179 10579 34840167
Abdominal pain lower 16.05 13.03 6 106179 10565 34840181
Lymphocyte count abnormal 16.04 13.03 19 106166 1179 34849567
CSF pressure increased 16.01 13.03 5 106180 20 34850726
Coagulopathy 16.01 13.03 22 106163 19767 34830979
Thought blocking 15.96 13.03 8 106177 131 34850615
Intellectual disability 15.94 13.03 20 106165 1318 34849428
Huntington's disease 15.87 13.03 6 106179 47 34850699
Full blood count abnormal 15.87 13.03 20 106165 18648 34832098
Cataract 15.82 13.03 35 106150 26151 34824595
Hepatic cancer 15.76 13.03 3 106182 8272 34842474
Premature baby 15.71 13.03 22 106163 19611 34831135
Foetal alcohol syndrome 15.64 13.03 8 106177 137 34850609
Glossoptosis 15.58 13.03 8 106177 138 34850608
Metastases to central nervous system 15.57 13.03 3 106182 8202 34842544
Heart rate irregular 15.57 13.03 15 106170 15792 34834954
Haematotoxicity 15.55 13.03 3 106182 8191 34842555
Embolism venous 15.47 13.03 21 106164 1495 34849251
Muscle contracture 15.47 13.03 19 106166 1225 34849521
Enteritis 15.41 13.03 3 106182 8139 34842607
Xanthoma 15.27 13.03 7 106178 93 34850653
Insulin resistance 15.25 13.03 14 106171 644 34850102
Neck pain 15.22 13.03 34 106151 25315 34825431
Injection site swelling 15.21 13.03 8 106177 11519 34839227
Tooth disorder 15.19 13.03 7 106178 10875 34839871
Electrolyte imbalance 15.19 13.03 85 106100 14327 34836419
Ischaemic gastritis 15.17 13.03 4 106181 7 34850739
Neutrophil count decreased 15.12 13.03 92 106093 51012 34799734
Distractibility 15.11 13.03 11 106174 363 34850383
Atelectasis 15.06 13.03 19 106166 17708 34833038
Blood glucose abnormal 15.04 13.03 46 106139 5906 34844840
Dyspepsia 15.00 13.03 59 106126 36673 34814073
Dermatillomania 14.96 13.03 6 106179 56 34850690
Hypokinesia 14.95 13.03 60 106125 8820 34841926
Bipolar I disorder 14.94 13.03 15 106170 772 34849974
Rash maculo-papular 14.86 13.03 41 106144 28410 34822336
Cholangitis 14.85 13.03 4 106181 8685 34842061
Ketosis-prone diabetes mellitus 14.83 13.03 4 106181 8 34850738
Resting tremor 14.82 13.03 14 106171 668 34850078
Ataxia 14.79 13.03 82 106103 13771 34836975
Cardiac disorder 14.75 13.03 74 106111 43052 34807694
Cholecystitis 14.73 13.03 7 106178 10681 34840065
Haemorrhage intracranial 14.72 13.03 16 106169 15930 34834816
Somatic symptom disorder 14.67 13.03 14 106171 677 34850069
Brief psychotic disorder with marked stressors 14.67 13.03 9 106176 222 34850524
Psychotic disorder due to a general medical condition 14.59 13.03 6 106179 60 34850686
Tuberculosis 14.56 13.03 4 106181 8573 34842173
Delusion of reference 14.50 13.03 5 106180 29 34850717
Depersonalisation/derealisation disorder 14.48 13.03 13 106172 581 34850165
Abscess 14.45 13.03 9 106176 11808 34838938
Musculoskeletal chest pain 14.45 13.03 6 106179 9912 34840834
Meige's syndrome 14.40 13.03 3 106182 0 34850746
Blood creatine phosphokinase BB increased 14.40 13.03 3 106182 0 34850746
Bladder injury 14.40 13.03 3 106182 0 34850746
Propulsive gait 14.40 13.03 3 106182 0 34850746
Tonic convulsion 14.38 13.03 18 106167 1183 34849563
Psychotic behaviour 14.36 13.03 14 106171 695 34850051
Homicide 14.31 13.03 16 106169 933 34849813
Hepatic cirrhosis 14.25 13.03 19 106166 17295 34833451
Nuchal rigidity 14.20 13.03 12 106173 494 34850252
Renal tubular necrosis 14.18 13.03 16 106169 15664 34835082
Pyelitis 14.16 13.03 7 106178 111 34850635
Hyponatraemic seizure 14.09 13.03 6 106179 66 34850680
Renal cyst 14.08 13.03 5 106180 9088 34841658
Progressive multifocal leukoencephalopathy 14.07 13.03 6 106179 9758 34840988
Saccadic eye movement 14.05 13.03 8 106177 171 34850575
Granulomatous liver disease 14.05 13.03 13 106172 604 34850142
Neonatal infection 14.04 13.03 11 106174 406 34850340
Epstein-Barr virus infection 14.04 13.03 3 106182 7625 34843121
Acanthosis nigricans 13.97 13.03 8 106177 173 34850573
Persistent depressive disorder 13.71 13.03 10 106175 331 34850415
Symptom masked 13.70 13.03 13 106172 624 34850122
Secondary tic 13.69 13.03 4 106181 12 34850734
Illogical thinking 13.69 13.03 4 106181 12 34850734
Somatic hallucination 13.59 13.03 5 106180 36 34850710
Convulsive threshold lowered 13.56 13.03 12 106173 526 34850220
Injection site erythema 13.55 13.03 17 106168 15882 34834864
Nephropathy toxic 13.54 13.03 11 106174 12577 34838169
Therapy interrupted 13.49 13.03 13 106172 13684 34837062
Social anxiety disorder 13.48 13.03 10 106175 340 34850406
Constipation 13.47 13.03 315 105870 136667 34714079
Ulcer 13.44 13.03 5 106180 8830 34841916
Breast tenderness 13.38 13.03 14 106171 757 34849989
Gastric infection 13.34 13.03 18 106167 1274 34849472
Meningioma 13.32 13.03 19 106166 1417 34849329
Negative symptoms in schizophrenia 13.24 13.03 5 106180 39 34850707
Blood albumin decreased 13.23 13.03 13 106172 13559 34837187
Joint range of motion decreased 13.21 13.03 3 106182 7309 34843437
Mobility decreased 13.21 13.03 47 106138 30081 34820665
Micturition frequency decreased 13.20 13.03 10 106175 351 34850395
Hyperammonaemia 13.20 13.03 46 106139 6321 34844425
Skin disorder 13.19 13.03 13 106172 13542 34837204
Therapy change 13.18 13.03 29 106156 3048 34847698
Acute coronary syndrome 13.17 13.03 13 106172 13532 34837214
Mood altered 13.13 13.03 58 106127 8894 34841852

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extrapyramidal disorder 3027.41 11.31 1292 165795 21387 79555914
Neuroleptic malignant syndrome 2785.76 11.31 1292 165795 26267 79551034
Gynaecomastia 2272.68 11.31 782 166305 6899 79570402
Hyperprolactinaemia 2029.04 11.31 636 166451 4040 79573261
Dystonia 1780.63 11.31 878 166209 20521 79556780
Aggression 1722.05 11.31 1162 165925 49796 79527505
Sedation 1522.56 11.31 1085 166002 50810 79526491
Suicide attempt 1435.48 11.31 1271 165816 81661 79495640
Psychotic disorder 1415.16 11.31 951 166136 40451 79536850
Blood prolactin increased 1271.01 11.31 430 166657 3581 79573720
Akathisia 1180.79 11.31 570 166517 12689 79564612
Intentional self-injury 1156.79 11.31 765 166322 31654 79545647
Drug interaction 1151.12 11.31 2623 164464 412560 79164741
Hallucination, auditory 1124.60 11.31 639 166448 20054 79557247
Dyskinesia 1110.05 11.31 846 166241 43927 79533374
Catatonia 1063.58 11.31 467 166620 8289 79569012
Treatment noncompliance 1058.82 11.31 877 166210 51391 79525910
Galactorrhoea 1042.73 11.31 362 166725 3284 79574017
Tardive dyskinesia 1013.10 11.31 478 166609 10093 79567208
Parkinsonism 993.48 11.31 546 166541 16038 79561263
Somnolence 910.18 11.31 1722 165365 237259 79340042
Sexual dysfunction 900.88 11.31 401 166686 7362 79569939
Intentional overdose 871.86 11.31 1092 165995 104868 79472433
Blood prolactin abnormal 868.31 11.31 315 166772 3286 79574015
Schizophrenia 818.01 11.31 469 166618 14971 79562330
Agitation 806.58 11.31 1019 166068 98696 79478605
Salivary hypersecretion 766.78 11.31 437 166650 13787 79563514
Disturbance in social behaviour 756.05 11.31 311 166776 4659 79572642
Anosognosia 752.69 11.31 287 166800 3477 79573824
Delusion 743.16 11.31 488 166599 19935 79557366
Abnormal behaviour 712.33 11.31 599 166488 35822 79541479
Suicidal ideation 688.05 11.31 824 166263 75516 79501785
Muscle rigidity 641.69 11.31 441 166646 19441 79557860
Arthralgia 625.34 11.31 210 166877 571593 79005708
Metabolic disorder 625.00 11.31 329 166758 8841 79568460
Paranoia 582.67 11.31 412 166675 19020 79558281
Hypothermia 559.57 11.31 428 166659 22318 79554983
Oculogyric crisis 550.69 11.31 214 166873 2738 79574563
Device leakage 546.42 11.31 319 166768 10537 79566764
Personality change 541.57 11.31 310 166777 9860 79567441
Diarrhoea 540.27 11.31 632 166455 879857 78697444
Pain 524.24 11.31 425 166662 703377 78873924
Syringe issue 489.94 11.31 247 166840 6051 79571250
Device malfunction 478.66 11.31 381 166706 21067 79556234
Priapism 469.73 11.31 216 166871 4289 79573012
Rash 449.70 11.31 334 166753 578024 78999277
Product dose omission issue 443.08 11.31 1330 165757 246207 79331094
Weight increased 427.34 11.31 1415 165672 275971 79301330
Blood creatine phosphokinase increased 420.32 11.31 601 166486 65489 79511812
Joint swelling 414.07 11.31 57 167030 288589 79288712
Pleurothotonus 408.54 11.31 165 166922 2351 79574950
Mania 402.41 11.31 322 166765 17938 79559363
Sopor 401.71 11.31 417 166670 32593 79544708
Restlessness 399.44 11.31 490 166597 46002 79531299
Nausea 389.74 11.31 898 166189 956298 78621003
Psychiatric decompensation 385.20 11.31 181 166906 3782 79573519
Rheumatoid arthritis 371.77 11.31 15 167072 208455 79368846
Delirium 365.87 11.31 645 166442 83982 79493319
Amenorrhoea 363.44 11.31 217 166870 7475 79569826
Infusion related reaction 361.50 11.31 33 167054 230204 79347097
Depressed level of consciousness 360.32 11.31 691 166396 95961 79481340
Dyspnoea 360.08 11.31 790 166297 856235 78721066
Rhabdomyolysis 358.60 11.31 716 166371 102415 79474886
Psychomotor hyperactivity 343.63 11.31 284 166803 16565 79560736
Electrocardiogram QT prolonged 341.60 11.31 650 166437 89736 79487565
Tachycardia 332.92 11.31 971 166116 176797 79400504
Pruritus 315.39 11.31 221 166866 394427 79182874
Overdose 314.60 11.31 974 166113 183232 79394069
Fatigue 313.08 11.31 958 166129 928769 78648532
Peripheral swelling 312.13 11.31 89 166998 269528 79307773
Emotional disorder 309.15 11.31 250 166837 14137 79563164
Completed suicide 308.92 11.31 1173 165914 244594 79332707
Psychotic symptom 308.67 11.31 138 166949 2559 79574742
Coma 304.50 11.31 660 166427 99989 79477312
Psychomotor skills impaired 301.44 11.31 168 166919 5069 79572232
Headache 295.85 11.31 577 166510 653195 78924106
Obesity 282.17 11.31 358 166729 34767 79542534
Arthropathy 281.74 11.31 24 167063 177087 79400214
Febrile neutropenia 281.11 11.31 69 167018 230930 79346371
Cogwheel rigidity 278.62 11.31 134 166953 2954 79574347
Pain in extremity 278.44 11.31 214 166873 364324 79212977
Irritability 270.16 11.31 380 166707 40764 79536537
Nasopharyngitis 265.37 11.31 100 166987 253781 79323520
Psychomotor retardation 262.76 11.31 163 166924 6021 79571280
Persecutory delusion 262.33 11.31 150 166937 4759 79572542
Tremor 257.41 11.31 863 166224 169220 79408081
Sinusitis 256.97 11.31 49 167038 195452 79381849
Obsessive-compulsive disorder 251.26 11.31 156 166931 5771 79571530
Toxicity to various agents 248.15 11.31 1621 165466 419919 79157382
Hypomania 244.95 11.31 168 166919 7376 79569925
Abdominal discomfort 242.31 11.31 111 166976 250616 79326685
Hallucination 238.75 11.31 544 166543 85201 79492100
Increased appetite 238.23 11.31 199 166888 11779 79565522
Tic 234.87 11.31 118 166969 2868 79574433
Anxiety 233.96 11.31 1086 166001 247426 79329875
Abnormal weight gain 233.32 11.31 113 166974 2531 79574770
Drug hypersensitivity 227.51 11.31 176 166911 298740 79278561
Serotonin syndrome 224.75 11.31 366 166721 44661 79532640
Cough 218.94 11.31 268 166819 366521 79210780
Hypersensitivity 217.18 11.31 141 166946 262098 79315203
Depressive symptom 215.58 11.31 146 166941 6277 79571024
Pneumonia aspiration 213.85 11.31 449 166638 66518 79510783
Alopecia 213.52 11.31 109 166978 231246 79346055
Back pain 210.81 11.31 196 166891 303984 79273317
Swelling 206.19 11.31 98 166989 216613 79360688
Stomatitis 203.32 11.31 32 167055 146725 79430576
Sluggishness 200.82 11.31 141 166946 6431 79570870
Hyperammonaemic encephalopathy 200.53 11.31 125 166962 4657 79572644
Hand deformity 197.89 11.31 4 167083 103915 79473386
Social avoidant behaviour 197.25 11.31 124 166963 4690 79572611
Emotional poverty 196.83 11.31 73 167014 814 79576487
Oromandibular dystonia 194.87 11.31 76 167011 982 79576319
Altered state of consciousness 193.19 11.31 337 166750 43485 79533816
Anaemia 191.37 11.31 404 166683 444611 79132690
Disturbance in attention 188.97 11.31 363 166724 50438 79526863
Mutism 187.34 11.31 94 166993 2278 79575023
Pemphigus 181.48 11.31 6 167081 99576 79477725
Tearfulness 178.47 11.31 127 166960 5918 79571383
Systemic lupus erythematosus 178.20 11.31 22 167065 121127 79456174
Dysarthria 176.13 11.31 418 166669 67204 79510097
Apathy 174.38 11.31 173 166914 12804 79564497
Hallucination, visual 174.24 11.31 274 166813 32455 79544846
Emotional distress 169.25 11.31 302 166785 39667 79537634
Mental impairment 168.92 11.31 204 166883 18832 79558469
Medication error 165.64 11.31 412 166675 68230 79509071
Urticaria 165.34 11.31 91 166996 185110 79392191
Depression suicidal 165.08 11.31 102 166985 3740 79573561
Contraindicated product administered 164.62 11.31 62 167025 157476 79419825
Glossodynia 161.60 11.31 15 167072 103322 79473979
Asthenia 160.58 11.31 543 166544 511146 79066155
Product use in unapproved indication 159.55 11.31 983 166104 249376 79327925
Drug intolerance 158.55 11.31 192 166895 263927 79313374
Drooling 155.52 11.31 116 166971 5818 79571483
Torticollis 155.18 11.31 83 167004 2304 79574997
Erythema 152.14 11.31 146 166941 223144 79354157
Confusional state 151.86 11.31 1163 165924 316834 79260467
Urinary incontinence 151.75 11.31 292 166795 40617 79536684
Malignant neoplasm progression 151.61 11.31 48 167039 135942 79441359
Hyperthermia 151.47 11.31 188 166899 17849 79559452
Polydipsia 150.91 11.31 119 166968 6486 79570815
Pneumonia 148.49 11.31 796 166291 659450 78917851
Abdominal pain upper 148.29 11.31 150 166937 223669 79353632
Malignant catatonia 147.88 11.31 50 167037 415 79576886
Thinking abnormal 147.19 11.31 159 166928 13002 79564299
Discomfort 144.27 11.31 42 167045 125575 79451726
Hypertonia 143.50 11.31 120 166967 7112 79570189
Psychiatric symptom 142.22 11.31 118 166969 6917 79570384
Sudden death 139.06 11.31 202 166885 22309 79554992
Myocarditis 138.62 11.31 198 166889 21535 79555766
Lower respiratory tract infection 136.44 11.31 50 167037 129170 79448131
Arthritis 136.43 11.31 36 167051 114844 79462457
Withdrawal syndrome 136.32 11.31 220 166867 26634 79550667
Infection 130.48 11.31 190 166897 241522 79335779
Disorientation 129.15 11.31 355 166732 62421 79514880
Chest discomfort 128.86 11.31 64 167023 137980 79439321
Psoriatic arthropathy 128.41 11.31 9 167078 77990 79499311
Seizure 128.25 11.31 754 166333 188080 79389221
Disease progression 127.39 11.31 119 166968 184243 79393058
Malaise 126.56 11.31 562 166525 489307 79087994
Behaviour disorder 125.78 11.31 105 166982 6208 79571093
Jaundice cholestatic 125.62 11.31 136 166951 11148 79566153
Logorrhoea 124.95 11.31 90 166997 4275 79573026
Inappropriate affect 124.64 11.31 62 167025 1474 79575827
Homicidal ideation 121.82 11.31 81 167006 3376 79573925
Intentional product use issue 121.54 11.31 85 167002 152027 79425274
Abdominal pain 118.99 11.31 418 166669 389151 79188150
Dyspnoea exertional 118.31 11.31 20 167067 87053 79490248
Stupor 118.04 11.31 105 166982 6767 79570534
Sinus tachycardia 117.25 11.31 247 166840 36661 79540640
Impaired healing 117.20 11.31 21 167066 87634 79489667
Speech disorder 117.12 11.31 313 166774 54132 79523169
Schizoaffective disorder 115.64 11.31 66 167021 2086 79575215
Rabbit syndrome 115.32 11.31 39 167048 324 79576977
Hyponatraemia 114.92 11.31 701 166386 177147 79400154
Neuropathy peripheral 114.17 11.31 78 167009 141227 79436074
Duodenal ulcer perforation 113.94 11.31 6 167081 66205 79511096
Blood glucose increased 113.63 11.31 510 166577 114465 79462836
Bradykinesia 113.24 11.31 110 166977 7933 79569368
Antipsychotic drug level increased 112.35 11.31 96 166991 5861 79571440
Refusal of treatment by patient 111.90 11.31 115 166972 8876 79568425
Hospitalisation 111.80 11.31 442 166645 93794 79483507
Hypoaesthesia 111.20 11.31 127 166960 179225 79398076
Product reconstitution quality issue 110.08 11.31 33 167054 176 79577125
COVID-19 109.83 11.31 101 166986 157573 79419728
Cardiac failure congestive 109.31 11.31 83 167004 142319 79434982
Spasmodic dysphonia 108.94 11.31 35 167052 243 79577058
Pericarditis 108.91 11.31 41 167046 104195 79473106
Enuresis 108.51 11.31 73 167014 3103 79574198
Injection site pain 108.51 11.31 69 167018 129769 79447532
Floppy iris syndrome 107.49 11.31 37 167050 326 79576975
Urinary retention 107.44 11.31 311 166776 56319 79520982
Asthma 107.26 11.31 76 167011 135019 79442282
Paraesthesia 107.01 11.31 127 166960 176196 79401105
Blister 104.74 11.31 60 167027 119416 79457885
Incoherent 104.19 11.31 103 166984 7589 79569712
Helicobacter infection 104.12 11.31 12 167075 69692 79507609
Mental disorder 103.55 11.31 213 166874 31089 79546212
Affective disorder 102.81 11.31 106 166981 8213 79569088
Miosis 102.39 11.31 145 166942 15644 79561657
Dysphagia 101.97 11.31 516 166571 121620 79455681
Herpes zoster 101.72 11.31 34 167053 93049 79484252
Soliloquy 101.54 11.31 42 167045 638 79576663
Mastitis 101.40 11.31 61 167026 2130 79575171
Osteoarthritis 100.59 11.31 29 167058 87280 79490021
Cognitive disorder 100.55 11.31 349 166738 69577 79507724
Product container issue 98.56 11.31 50 167037 1241 79576060
Therapeutic product effect decreased 98.40 11.31 119 166968 163744 79413557
Anticholinergic syndrome 97.79 11.31 72 167015 3539 79573762
Injection site erythema 97.73 11.31 22 167065 78175 79499126
Productive cough 96.99 11.31 32 167055 88299 79489002
Wrong patient received product 96.57 11.31 79 167008 4539 79572762
Delusion of grandeur 96.49 11.31 51 167036 1381 79575920
Pituitary tumour benign 94.76 11.31 62 167025 2514 79574787
Antipsychotic drug level below therapeutic 94.67 11.31 48 167039 1190 79576111
Hallucinations, mixed 94.60 11.31 93 166994 6806 79570495
Granulocytopenia 94.15 11.31 118 166969 11313 79565988
Diabetes mellitus 93.24 11.31 368 166719 78022 79499279
Gastrointestinal disorder 92.81 11.31 72 167015 122133 79455168
Vomiting 92.74 11.31 920 166167 664908 78912393
Blunted affect 92.59 11.31 36 167051 461 79576840
Condition aggravated 92.57 11.31 1519 165568 499605 79077696
Disinhibition 91.86 11.31 61 167026 2537 79574764
Fibromyalgia 91.45 11.31 13 167074 64327 79512974
Metabolic syndrome 91.28 11.31 62 167025 2678 79574623
Drug abuse 90.79 11.31 618 166469 162073 79415228
Opisthotonus 90.63 11.31 39 167048 657 79576644
Foreign body 90.54 11.31 63 167024 2831 79574470
Chills 90.37 11.31 122 166965 160112 79417189
Wound 90.08 11.31 67 167020 116112 79461189
Oropharyngeal spasm 89.59 11.31 34 167053 406 79576895
Folliculitis 89.42 11.31 7 167080 55373 79521928
Needle issue 89.20 11.31 123 166964 12945 79564356
Myalgia 87.89 11.31 159 166928 185482 79391819
Epilepsy 86.96 11.31 234 166853 40626 79536675
Insomnia 86.61 11.31 839 166248 244331 79332970
Interstitial lung disease 85.94 11.31 66 167021 112534 79464767
Wrong product administered 85.60 11.31 100 166987 8912 79568389
Protrusion tongue 85.49 11.31 33 167054 414 79576887
Sepsis 84.28 11.31 286 166801 269142 79308159
Polydipsia psychogenic 84.10 11.31 27 167060 187 79577114
Euphoric mood 84.06 11.31 92 166995 7634 79569667
Obsessive thoughts 83.97 11.31 43 167044 1089 79576212
Inflammation 83.73 11.31 46 167041 93707 79483594
Hypersexuality 83.56 11.31 49 167038 1631 79575670
Product administration error 83.05 11.31 197 166890 31649 79545652
Impaired self-care 82.53 11.31 58 167029 2649 79574652
Anger 82.24 11.31 137 166950 17025 79560276
Chest pain 81.45 11.31 310 166777 281994 79295307
Embolism venous 81.35 11.31 69 167018 4170 79573131
C-reactive protein abnormal 81.33 11.31 5 167082 48362 79528939
Influenza 81.17 11.31 91 166996 129515 79447786
Major depression 80.92 11.31 97 166990 8883 79568418
Irritable bowel syndrome 80.88 11.31 16 167071 62225 79515076
Gastrointestinal haemorrhage 80.77 11.31 115 166972 147604 79429697
Psoriasis 79.94 11.31 44 167043 89543 79487758
Gaze palsy 79.32 11.31 59 167028 2946 79574355
Diet refusal 79.20 11.31 38 167049 833 79576468
Product quality issue 79.01 11.31 201 166886 33739 79543562
Autonomic nervous system imbalance 78.05 11.31 70 167017 4560 79572741
Migraine 78.03 11.31 43 167044 87450 79489851
Maternal exposure during pregnancy 77.97 11.31 103 166984 136435 79440866
Blood triglycerides increased 77.80 11.31 150 166937 20890 79556411
Electroencephalogram abnormal 77.78 11.31 75 167012 5359 79571942
Bronchitis 77.24 11.31 96 166991 130548 79446753
Ascites 76.82 11.31 31 167056 75531 79501770
Staring 76.77 11.31 55 167032 2590 79574711
Inappropriate antidiuretic hormone secretion 76.60 11.31 170 166917 26143 79551158
Blood pressure increased 76.33 11.31 210 166877 211150 79366151
Oropharyngeal pain 76.20 11.31 70 167017 109283 79468018
Cytomegalovirus infection 76.19 11.31 3 167084 42641 79534660
Weight decreased 75.93 11.31 435 166652 354763 79222538
Incorrect dose administered 75.75 11.31 340 166747 76290 79501011
Refusal of examination 75.52 11.31 25 167062 193 79577108
Leukopenia 75.06 11.31 459 166628 116054 79461247
Faecaloma 74.69 11.31 106 166981 11458 79565843
Knee arthroplasty 74.16 11.31 4 167083 43244 79534057
Generalised tonic-clonic seizure 73.72 11.31 231 166856 43679 79533622
Dementia 73.69 11.31 161 166926 24498 79552803
Parkinsonian gait 73.20 11.31 37 167050 911 79576390
Accidental exposure to product 71.36 11.31 184 166903 31138 79546163
Ataxia 70.91 11.31 160 166927 24879 79552422
Musculoskeletal pain 70.75 11.31 66 167021 102288 79475013
Anaphylactic reaction 70.65 11.31 44 167043 83699 79493602
Somatic symptom disorder of pregnancy 70.61 11.31 20 167067 84 79577217
Intrusive thoughts 70.33 11.31 30 167057 494 79576807
Ileus paralytic 69.38 11.31 93 166994 9527 79567774
Suicidal behaviour 68.86 11.31 56 167031 3191 79574110
Fluid retention 68.78 11.31 30 167057 69779 79507522
Colitis 68.37 11.31 34 167053 73273 79504028
Posture abnormal 68.26 11.31 60 167027 3806 79573495
Water intoxication 68.05 11.31 33 167054 741 79576560
Underdose 67.70 11.31 187 166900 32964 79544337
Flushing 67.02 11.31 52 167035 88216 79489085
Pyrexia 67.00 11.31 1010 166077 677699 78899602
Intellectual disability 66.97 11.31 39 167048 1281 79576020
Bradyphrenia 66.47 11.31 96 166991 10544 79566757
Erectile dysfunction 66.21 11.31 114 166973 14550 79562751
Injection site reaction 65.35 11.31 17 167070 54768 79522533
Drug withdrawal syndrome 65.20 11.31 190 166897 34528 79542773
Contusion 64.69 11.31 134 166953 148642 79428659
Hostility 64.69 11.31 47 167040 2263 79575038
Mood swings 64.25 11.31 134 166953 19746 79557555
Dyslipidaemia 64.15 11.31 99 166988 11534 79565767
Decreased appetite 64.04 11.31 437 166650 341981 79235320
Reduced facial expression 63.56 11.31 50 167037 2715 79574586
Pneumonitis 63.47 11.31 24 167063 60836 79516465
Conduction disorder 62.80 11.31 54 167033 3325 79573976
Rhinorrhoea 62.77 11.31 41 167046 76033 79501268
Systemic infection 62.41 11.31 89 166998 9663 79567638
Product physical issue 62.25 11.31 59 167028 4126 79573175
Device breakage 61.91 11.31 93 166994 10582 79566719
Atrial fibrillation 61.90 11.31 210 166877 197676 79379625
Bone pain 61.53 11.31 20 167067 55722 79521579
Myoclonus 61.49 11.31 161 166926 27499 79549802
Impulsive behaviour 61.46 11.31 50 167037 2850 79574451
Osteonecrosis of jaw 60.81 11.31 9 167078 43217 79534084
Grandiosity 60.74 11.31 28 167059 559 79576742
Dizziness 60.67 11.31 759 166328 525682 79051619
Flat affect 60.53 11.31 43 167044 1998 79575303
Antipsychotic drug level above therapeutic 59.80 11.31 43 167044 2037 79575264
Cytokine release syndrome 59.69 11.31 4 167083 35994 79541307
Nasal congestion 59.53 11.31 44 167043 76508 79500793
Bipolar disorder 59.43 11.31 77 167010 7630 79569671
Hypotonia 59.36 11.31 101 166986 12769 79564532
Mobility decreased 59.29 11.31 103 166984 122072 79455229
Septic shock 59.16 11.31 104 166983 122697 79454604
Bladder dilatation 59.08 11.31 43 167044 2076 79575225
Negativism 58.90 11.31 31 167056 832 79576469
Throat irritation 58.83 11.31 8 167079 40938 79536363
Eye movement disorder 58.62 11.31 78 167009 7933 79569368
Diabetic coma 58.33 11.31 35 167052 1216 79576085
Haemoglobin decreased 58.33 11.31 253 166834 221866 79355435
Treatment failure 58.16 11.31 174 166913 170312 79406989
Psychosexual disorder 57.85 11.31 18 167069 111 79577190
Communication disorder 57.70 11.31 56 167031 4034 79573267
Blood pressure fluctuation 57.03 11.31 35 167052 67110 79510191
Night sweats 56.96 11.31 19 167068 52076 79525225
Blood pressure systolic increased 56.78 11.31 35 167052 66951 79510350
Injection site bruising 56.62 11.31 9 167078 40993 79536308
Bursitis 56.57 11.31 5 167082 35839 79541462
Hypokinesia 56.45 11.31 124 166963 18936 79558365
Dyspepsia 56.12 11.31 88 166999 108599 79468702
Thrombosis 56.06 11.31 56 167031 84044 79493257
Tourette's disorder 55.96 11.31 16 167071 70 79577231
Feeling guilty 55.91 11.31 30 167057 838 79576463
Cellulitis 55.65 11.31 89 166998 108971 79468330
Hypervolaemia 55.41 11.31 11 167076 42679 79534622
Movement disorder 54.90 11.31 153 166934 27106 79550195
Injection site pruritus 54.67 11.31 11 167076 42272 79535029
Eosinophil count decreased 54.61 11.31 50 167037 3346 79573955
Muscle injury 54.35 11.31 17 167070 48544 79528757
Sinus bradycardia 54.13 11.31 145 166942 25102 79552199
Hyperphagia 54.09 11.31 44 167043 2508 79574793
Psychotic behaviour 53.72 11.31 32 167055 1097 79576204
Plasma cell mastitis 53.67 11.31 13 167074 24 79577277
Fall 53.64 11.31 1369 165718 486260 79091041
Hypometabolism 52.55 11.31 17 167070 121 79577180
Compulsive sexual behaviour 52.46 11.31 20 167067 242 79577059
Epistaxis 52.32 11.31 96 166991 111419 79465882
Haematochezia 52.22 11.31 64 167023 87581 79489720
Upper respiratory tract infection 51.81 11.31 69 167018 91099 79486202
Anaphylactic shock 51.80 11.31 7 167080 35989 79541312
Insurance issue 51.78 11.31 62 167025 5671 79571630
Diverticulitis 51.56 11.31 16 167071 45920 79531381
Abulia 51.39 11.31 30 167057 990 79576311
Clostridium difficile infection 51.38 11.31 13 167074 42672 79534629
Bradycardia 51.36 11.31 471 166616 135086 79442215
Dysgeusia 51.13 11.31 28 167059 57149 79520152
Myelosuppression 51.03 11.31 11 167076 40285 79537016
Influenza like illness 51.03 11.31 45 167042 71662 79505639
Tachyphrenia 50.83 11.31 39 167048 2041 79575260
Breast hyperplasia 50.72 11.31 17 167070 137 79577164
Breast enlargement 50.67 11.31 35 167052 1554 79575747
Skin ulcer 50.67 11.31 25 167062 54125 79523176
Acute myocardial infarction 50.55 11.31 52 167035 76984 79500317
Obsessive-compulsive symptom 50.46 11.31 18 167069 178 79577123
Coronary artery disease 50.43 11.31 38 167049 65436 79511865
Off label use 50.14 11.31 2351 164736 904864 78672437
Basal cell carcinoma 49.85 11.31 9 167078 37366 79539935
Pleural effusion 49.73 11.31 148 166939 145114 79432187
Electrocardiogram abnormal 49.70 11.31 109 166978 16628 79560673
Tachypnoea 49.58 11.31 164 166923 31899 79545402
Choking 49.38 11.31 90 166997 12011 79565290
Full blood count abnormal 49.36 11.31 12 167075 40462 79536839
Ideas of reference 49.07 11.31 17 167070 153 79577148
Prostate cancer 49.00 11.31 6 167081 33262 79544039
Injection site swelling 48.46 11.31 19 167068 47113 79530188
Echolalia 48.41 11.31 21 167066 361 79576940
Somatic symptom disorder 48.08 11.31 41 167046 2496 79574805
Loss of libido 48.06 11.31 42 167045 2643 79574658
Multiple organ dysfunction syndrome 47.60 11.31 114 166973 120132 79457169
Brain injury 47.44 11.31 86 167001 11431 79565870
Respiratory dyskinesia 47.43 11.31 13 167074 47 79577254
Rash pruritic 47.40 11.31 48 167039 71581 79505720
Pulmonary embolism 47.29 11.31 559 166528 171095 79406206
Ill-defined disorder 47.29 11.31 41 167046 65834 79511467
Gestational diabetes 47.17 11.31 62 167025 6231 79571070
Hyperreflexia 47.14 11.31 72 167015 8313 79568988
Respiratory failure 46.92 11.31 207 166880 180704 79396597
Wheezing 46.66 11.31 110 166977 116554 79460747
Joint range of motion decreased 46.66 11.31 7 167080 33275 79544026
Muscle spasms 46.49 11.31 198 166889 174532 79402769
Myocardial infarction 46.36 11.31 213 166874 183916 79393385
Rebound effect 46.32 11.31 66 167021 7160 79570141
Delusional disorder, persecutory type 45.70 11.31 22 167065 486 79576815
Stereotypy 45.53 11.31 27 167060 918 79576383
Illness anxiety disorder 45.44 11.31 18 167069 243 79577058
Total lung capacity increased 45.32 11.31 38 167049 2260 79575041
Paroxysmal perceptual alteration 45.30 11.31 10 167077 9 79577292
Neoplasm progression 45.21 11.31 26 167061 51656 79525645
Substance-induced psychotic disorder 45.20 11.31 45 167042 3344 79573957
Respiratory depression 45.13 11.31 144 166943 27486 79549815
Cerebral atrophy 44.92 11.31 69 167018 8006 79569295
Plasma cell myeloma 44.90 11.31 28 167059 53231 79524070
Muscular weakness 44.72 11.31 179 166908 160550 79416751
Hot flush 44.70 11.31 30 167057 54847 79522454
Pulmonary arterial hypertension 44.65 11.31 4 167083 28362 79548939
Attention deficit hyperactivity disorder 44.24 11.31 44 167043 3265 79574036
Sexually inappropriate behaviour 44.23 11.31 22 167065 523 79576778
Cystitis 44.07 11.31 28 167059 52704 79524597
Haemoptysis 43.78 11.31 32 167055 55967 79521334
Oedema peripheral 43.72 11.31 329 166758 251959 79325342
Injury 43.68 11.31 59 167028 77437 79499864
Inappropriate schedule of product administration 43.60 11.31 450 166637 133178 79444123
Decreased gait velocity 43.58 11.31 16 167071 173 79577128
Illusion 43.33 11.31 33 167054 1708 79575593
Wolff-Parkinson-White syndrome 42.84 11.31 18 167069 285 79577016
Visceral congestion 42.65 11.31 26 167061 930 79576371
Hyperkalaemia 42.53 11.31 112 166975 114286 79463015
Melaena 42.38 11.31 39 167048 60851 79516450
Dysphemia 42.34 11.31 44 167043 3440 79573861
Sciatica 42.21 11.31 9 167078 33213 79544088
Pain in jaw 42.14 11.31 22 167065 46129 79531172
Prolactin-producing pituitary tumour 41.86 11.31 14 167073 112 79577189
Pulmonary fibrosis 41.83 11.31 20 167067 44092 79533209
Eating disorder 41.52 11.31 116 166971 20581 79556720
Intentional product misuse 41.43 11.31 341 166746 94824 79482477
Screaming 41.34 11.31 46 167041 3887 79573414
Depression 41.33 11.31 661 166426 216129 79361172
Mucosal inflammation 41.14 11.31 59 167028 75521 79501780
Pulmonary mass 40.95 11.31 6 167081 29028 79548273
Pneumocystis jirovecii pneumonia 40.91 11.31 9 167078 32499 79544802
Dysphoria 40.80 11.31 50 167037 4684 79572617
Libido decreased 40.78 11.31 53 167034 5268 79572033
Acute psychosis 40.73 11.31 47 167040 4133 79573168
Waxy flexibility 40.64 11.31 17 167070 266 79577035
Neuralgia 40.51 11.31 10 167077 33374 79543927
Distractibility 40.44 11.31 23 167064 722 79576579
Heart rate decreased 40.17 11.31 53 167034 70263 79507038
Device expulsion 39.77 11.31 4 167083 25857 79551444
Metastases to bone 39.68 11.31 3 167084 24424 79552877
Osteoporosis 39.67 11.31 33 167054 54079 79523222
Choreoathetosis 39.61 11.31 30 167057 1540 79575761
Bipolar I disorder 39.52 11.31 34 167053 2095 79575206
Paradoxical drug reaction 39.41 11.31 61 167026 7124 79570177
Delusional disorder, unspecified type 39.40 11.31 23 167064 759 79576542
Eosinophilic pneumonia acute 39.35 11.31 26 167061 1072 79576229
Negative symptoms in schizophrenia 39.28 11.31 14 167073 138 79577163
Full blood count decreased 39.10 11.31 5 167082 26814 79550487
Red blood cell sedimentation rate increased 38.94 11.31 24 167063 45918 79531383
Frontotemporal dementia 38.90 11.31 21 167066 594 79576707
Localised infection 38.87 11.31 15 167072 37560 79539741
Oedema 38.68 11.31 125 166962 119455 79457846
Nephrolithiasis 38.45 11.31 33 167054 53258 79524043
Ulcer 38.33 11.31 8 167079 29964 79547337
Oxygen saturation decreased 38.29 11.31 140 166947 128907 79448394
Dry skin 38.08 11.31 52 167035 67943 79509358
Schizophreniform disorder 38.08 11.31 14 167073 152 79577149
Platelet count decreased 38.08 11.31 245 166842 194419 79382882
Fungal infection 37.98 11.31 20 167067 41728 79535573
Phagophobia 37.96 11.31 11 167076 51 79577250
Precocious puberty 37.88 11.31 17 167070 318 79576983
Hyperkinesia 37.81 11.31 37 167050 2692 79574609
Depressed mood 37.78 11.31 201 166886 48279 79529022
Hypomagnesaemia 37.73 11.31 26 167061 46885 79530416
Sedation complication 37.72 11.31 94 166993 15575 79561726
Compulsions 37.71 11.31 18 167069 390 79576911
Oral pain 37.67 11.31 10 167077 31788 79545513
Product tampering 36.89 11.31 18 167069 410 79576891
Binge eating 36.79 11.31 19 167068 490 79576811
Device related infection 36.64 11.31 13 167074 34281 79543020
Mydriasis 36.49 11.31 100 166987 17543 79559758
Rectal haemorrhage 36.40 11.31 65 167022 76235 79501066
Palmar-plantar erythrodysaesthesia syndrome 36.37 11.31 12 167075 33122 79544179
Personality change due to a general medical condition 36.32 11.31 15 167072 227 79577074
Morbid thoughts 36.27 11.31 22 167065 780 79576521
Poisoning 36.20 11.31 126 166961 25146 79552155
Hyperammonaemia 36.11 11.31 75 167012 11018 79566283
Osteomyelitis 35.91 11.31 12 167075 32853 79544448
Posturing 35.49 11.31 24 167063 1029 79576272
Small intestinal obstruction 35.45 11.31 7 167080 27265 79550036
Gastric disorder 35.45 11.31 17 167070 37416 79539885
Candida infection 35.22 11.31 18 167069 38196 79539105
Stress 35.19 11.31 71 167016 79541 79497760
Incontinence 35.19 11.31 86 167001 14078 79563223
Polyuria 35.03 11.31 89 166998 14925 79562376
Drug level increased 34.82 11.31 170 166917 39481 79537820
Physical assault 34.62 11.31 28 167059 1583 79575718
Product packaging quantity issue 34.52 11.31 26 167061 1323 79575978
Nuchal rigidity 34.46 11.31 24 167063 1080 79576221
Acute kidney injury 34.44 11.31 827 166260 518577 79058724
Asthma-chronic obstructive pulmonary disease overlap syndrome 34.42 11.31 38 167049 3183 79574118
COVID-19 pneumonia 34.31 11.31 9 167078 28840 79548461
Hepatocellular injury 34.19 11.31 193 166894 47400 79529901
Resting tremor 33.88 11.31 27 167060 1494 79575807
Oral herpes 33.75 11.31 8 167079 27446 79549855
Adrenal insufficiency 33.67 11.31 9 167078 28478 79548823
Autism spectrum disorder 33.54 11.31 24 167063 1128 79576173
Hypotension 33.42 11.31 1181 165906 439136 79138165
Metastases to liver 33.36 11.31 9 167078 28305 79548996
Therapy interrupted 33.28 11.31 12 167075 31329 79545972
Pulmonary hypertension 33.22 11.31 31 167056 48049 79529252
Rebound psychosis 33.05 11.31 16 167071 358 79576943
Overweight 32.84 11.31 42 167045 4108 79573193
Dementia with Lewy bodies 32.69 11.31 21 167066 825 79576476
Mouth ulceration 32.62 11.31 20 167067 38374 79538927
Homosexuality 32.53 11.31 9 167078 34 79577267
Self-injurious ideation 32.29 11.31 39 167048 3599 79573702
Lung disorder 32.17 11.31 76 167011 80481 79496820
Feeling hot 32.14 11.31 47 167040 59687 79517614
Oral candidiasis 32.05 11.31 11 167076 29617 79547684
Bundle branch block right 31.97 11.31 72 167015 11179 79566122
Substance abuse 31.76 11.31 69 167018 10457 79566844
Facial spasm 31.70 11.31 20 167067 761 79576540
Device occlusion 31.58 11.31 74 167013 11792 79565509
Lethargy 31.56 11.31 284 166803 81008 79496293
Cystoid macular oedema 31.54 11.31 29 167058 1951 79575350
Potentiating drug interaction 31.54 11.31 62 167025 8757 79568544
Alcohol abuse 31.50 11.31 47 167040 5316 79571985
Grimacing 31.36 11.31 19 167068 672 79576629
Death 31.27 11.31 926 166161 565588 79011713
Neck pain 31.05 11.31 70 167017 75347 79501954
Chronic kidney disease 30.98 11.31 57 167030 66097 79511204
Breast discharge 30.91 11.31 19 167068 690 79576611
Tenderness 30.88 11.31 6 167081 23636 79553665
Mental status changes 30.81 11.31 243 166844 66716 79510585
Activation syndrome 30.76 11.31 14 167073 271 79577030
Poriomania 30.76 11.31 13 167074 209 79577092
Poisoning deliberate 30.63 11.31 98 166989 18730 79558571
Hypoxia 30.63 11.31 112 166975 103131 79474170
Convulsive threshold lowered 30.53 11.31 21 167066 926 79576375
Long QT syndrome 30.51 11.31 49 167038 5906 79571395
Ejaculation failure 30.41 11.31 15 167072 350 79576951
Adulterated product 30.35 11.31 14 167073 280 79577021
Haemorrhage 30.34 11.31 94 166993 91024 79486277
Chorea 30.23 11.31 31 167056 2386 79574915
Ejaculation disorder 30.23 11.31 17 167070 522 79576779
Frequent bowel movements 30.21 11.31 12 167075 29527 79547774
Hypertension 30.05 11.31 500 166587 330492 79246809
Pressure of speech 29.95 11.31 23 167064 1205 79576096
Flight of ideas 29.90 11.31 20 167067 842 79576459
Cardio-respiratory arrest 29.70 11.31 353 166734 108157 79469144
Nodule 29.69 11.31 6 167081 22988 79554313
Foot deformity 29.62 11.31 7 167080 24067 79553234
Angina pectoris 29.54 11.31 39 167048 51693 79525608
Aphasia 29.38 11.31 183 166904 46549 79530752
Wrong dose 29.33 11.31 26 167061 1668 79575633
Device dislocation 29.23 11.31 9 167078 25961 79551340
Hypocalcaemia 29.17 11.31 37 167050 49887 79527414
Wrong technique in product usage process 29.15 11.31 259 166828 73616 79503685
Gout 28.91 11.31 8 167079 24741 79552560
Menstrual disorder 28.84 11.31 39 167048 4028 79573273
Multiple sclerosis relapse 28.76 11.31 33 167054 46500 79530801
Affect lability 28.65 11.31 69 167018 11190 79566111
Delusion of reference 28.14 11.31 11 167076 143 79577158
Bacteraemia 28.02 11.31 17 167070 32807 79544494
Loss of consciousness 27.96 11.31 501 166586 167442 79409859
Tension 27.90 11.31 40 167047 4364 79572937
Slow response to stimuli 27.66 11.31 26 167061 1799 79575502
Lymphadenopathy 27.58 11.31 43 167044 53204 79524097
Tongue spasm 27.41 11.31 10 167077 106 79577195
Torsade de pointes 27.41 11.31 96 166991 19216 79558085
Suspiciousness 27.35 11.31 17 167070 630 79576671
Self esteem decreased 27.18 11.31 20 167067 982 79576319
International normalised ratio increased 27.09 11.31 89 166998 84632 79492669
Skin disorder 27.05 11.31 19 167068 33924 79543377
Erection increased 26.93 11.31 14 167073 366 79576935
Muscle twitching 26.85 11.31 113 166974 24651 79552650
Product label issue 26.84 11.31 18 167069 761 79576540
Bone disorder 26.84 11.31 4 167083 19109 79558192
Personality disorder 26.73 11.31 47 167040 6099 79571202
Ear pain 26.72 11.31 18 167069 32851 79544450
Blood pressure diastolic decreased 26.72 11.31 15 167072 30201 79547100
Hyperbilirubinaemia 26.70 11.31 9 167078 24509 79552792
Skin discolouration 26.58 11.31 28 167059 41006 79536295
Liquid product physical issue 26.49 11.31 21 167066 1153 79576148
Neoplasm malignant 26.43 11.31 17 167070 31793 79545508
Retrograde ejaculation 26.41 11.31 13 167074 302 79576999
Keratoconus 26.38 11.31 10 167077 119 79577182
Adverse drug reaction 26.31 11.31 233 166854 66159 79511142
Urinary tract infection 26.13 11.31 411 166676 274101 79303200
Idiopathic intracranial hypertension 26.12 11.31 33 167054 3189 79574112
Tubulointerstitial nephritis 26.01 11.31 25 167062 38210 79539091
Hyperlactacidaemia 25.92 11.31 44 167043 5551 79571750
Blood pressure systolic abnormal 25.67 11.31 3 167084 17244 79560057
Mastication disorder 25.59 11.31 30 167057 2683 79574618
Mood altered 25.58 11.31 89 166998 17758 79559543
Drug ineffective 25.57 11.31 2611 164476 1078302 78498999
Therapeutic product effect variable 25.55 11.31 26 167061 1983 79575318
Gastroenteritis viral 25.54 11.31 10 167077 24821 79552480
Immunodeficiency 25.50 11.31 7 167080 21761 79555540
Breast discomfort 25.49 11.31 14 167073 410 79576891
Joint stiffness 25.19 11.31 29 167058 40801 79536500
Type 1 diabetes mellitus 25.18 11.31 49 167038 6870 79570431
Acute myeloid leukaemia 25.00 11.31 17 167070 30868 79546433
Faeces discoloured 24.99 11.31 15 167072 29112 79548189
Tongue movement disturbance 24.89 11.31 14 167073 430 79576871
Uveitis 24.87 11.31 3 167084 16827 79560474
Cataract 24.49 11.31 59 167028 62061 79515240
Lower limb fracture 24.46 11.31 9 167078 23206 79554095
Cardiac failure 24.46 11.31 207 166880 154635 79422666
Hypertriglyceridaemia 24.18 11.31 70 167017 12670 79564631
Prader-Willi syndrome 24.13 11.31 6 167081 13 79577288
Sarcopenia 24.12 11.31 14 167073 457 79576844
Boredom 24.06 11.31 7 167080 33 79577268
Cerebrovascular stenosis 24.05 11.31 10 167077 154 79577147
Diabetes insipidus 24.02 11.31 41 167046 5196 79572105
Status epilepticus 23.91 11.31 110 166977 24931 79552370
Akinesia 23.85 11.31 32 167055 3280 79574021
Attention-seeking behaviour 23.75 11.31 9 167078 107 79577194
Sneezing 23.68 11.31 6 167081 19677 79557624
Proteinuria 23.60 11.31 20 167067 32482 79544819
Altered visual depth perception 23.57 11.31 13 167074 384 79576917
Myoglobin blood increased 23.55 11.31 31 167056 3120 79574181
Self esteem inflated 23.51 11.31 5 167082 3 79577298
Intervertebral disc protrusion 23.51 11.31 10 167077 23611 79553690
Hyperhidrosis 23.49 11.31 447 166640 151045 79426256
Colitis ulcerative 23.30 11.31 23 167064 34719 79542582
Atrioventricular block second degree 23.29 11.31 49 167038 7263 79570038
Cytopenia 23.05 11.31 7 167080 20376 79556925
Bacterial infection 23.02 11.31 19 167068 31261 79546040
Claustrophobia 23.00 11.31 20 167067 1250 79576051
Selective mutism 22.99 11.31 8 167079 73 79577228
Meige's syndrome 22.92 11.31 5 167082 4 79577297
Spinal stenosis 22.89 11.31 3 167084 15788 79561513
Loss of personal independence in daily activities 22.75 11.31 124 166963 102456 79474845
Osteonecrosis 22.75 11.31 19 167068 31076 79546225
Trismus 22.74 11.31 41 167046 5426 79571875
Disorganised speech 22.67 11.31 25 167062 2092 79575209
CSF pressure increased 22.64 11.31 11 167076 248 79577053
Flatulence 22.61 11.31 34 167053 42690 79534611
Tobacco user 22.53 11.31 16 167071 743 79576558
Megacolon 22.52 11.31 32 167055 3463 79573838
Product dispensing error 22.46 11.31 70 167017 13193 79564108
Aptyalism 22.42 11.31 16 167071 749 79576552
Type 2 diabetes mellitus 22.39 11.31 200 166887 56922 79520379
Exhibitionism 22.38 11.31 7 167080 44 79577257
Oral discharge 22.29 11.31 11 167076 257 79577044
Hypophosphataemia 22.23 11.31 7 167080 19906 79557395
Unresponsive to stimuli 22.22 11.31 196 166891 55592 79521709
Sinus congestion 22.20 11.31 7 167080 19889 79557412
Pseudomonas infection 22.20 11.31 8 167079 20895 79556406
Tooth infection 22.16 11.31 6 167081 18826 79558475
Spinal pain 22.13 11.31 3 167084 15389 79561912
Musculoskeletal discomfort 22.10 11.31 7 167080 19828 79557473
Neuroleptic-induced deficit syndrome 22.04 11.31 6 167081 21 79577280
Electrolyte imbalance 22.03 11.31 125 166962 30756 79546545
Hyponatraemic seizure 22.00 11.31 14 167073 541 79576760
Skin exfoliation 21.99 11.31 52 167035 55048 79522253
Parkinson's disease 21.94 11.31 22 167065 1649 79575652
Hypercalcaemia 21.91 11.31 29 167058 38401 79538900
Withdrawal catatonia 21.91 11.31 10 167077 195 79577106
Tooth disorder 21.82 11.31 14 167073 26219 79551082
Labelled drug-drug interaction medication error 21.79 11.31 115 166972 27535 79549766
Limb discomfort 21.74 11.31 22 167065 32828 79544473
Thrombocytopenia 21.73 11.31 408 166679 264851 79312450
Head titubation 21.64 11.31 17 167070 921 79576380
Antipsychotic drug level decreased 21.62 11.31 19 167068 1205 79576096
Helplessness 21.59 11.31 12 167075 360 79576941
Hypernatraemia 21.53 11.31 73 167014 14378 79562923
Target skin lesion 21.51 11.31 9 167078 141 79577160
Graft versus host disease 21.43 11.31 3 167084 15023 79562278
Burning sensation 21.33 11.31 58 167029 58574 79518727
Hepatic cirrhosis 21.31 11.31 25 167062 34881 79542420
Circadian rhythm sleep disorder 21.30 11.31 15 167072 687 79576614
Pre-existing disease 21.23 11.31 10 167077 210 79577091
Drug screen false positive 21.17 11.31 18 167069 1091 79576210
Skin reaction 21.15 11.31 4 167083 16064 79561237
Laryngitis 21.10 11.31 4 167083 16035 79561266
Haemorrhoids 21.06 11.31 18 167069 29110 79548191
Drug delivery system malfunction 21.02 11.31 15 167072 702 79576599
Compartment syndrome 20.99 11.31 38 167049 5044 79572257
Oligomenorrhoea 20.85 11.31 15 167072 711 79576590
Deafness 20.78 11.31 9 167078 21028 79556273
Stiff tongue 20.68 11.31 4 167083 0 79577301
Accidental overdose 20.66 11.31 148 166939 39433 79537868
Lack of spontaneous speech 20.64 11.31 10 167077 224 79577077
Injection site rash 20.61 11.31 6 167081 17948 79559353
Grip strength decreased 20.60 11.31 10 167077 21859 79555442
Somatic hallucination 20.51 11.31 7 167080 60 79577241
Dementia Alzheimer's type 20.41 11.31 17 167070 1002 79576299
Epstein-Barr virus infection 20.28 11.31 3 167084 14413 79562888
Food craving 20.27 11.31 21 167066 1636 79575665
Abdominal distension 20.25 11.31 157 166930 119493 79457808
Lactation disorder 20.17 11.31 10 167077 236 79577065
Gambling disorder 20.11 11.31 23 167064 2003 79575298
Product substitution issue 20.10 11.31 90 166997 20166 79557135
Sinus disorder 20.08 11.31 11 167076 22453 79554848
Language disorder 20.08 11.31 29 167058 3185 79574116
Gastrooesophageal reflux disease 19.97 11.31 132 166955 104114 79473187
White blood cell count decreased 19.96 11.31 276 166811 188012 79389289
Lip dry 19.95 11.31 4 167083 15414 79561887
Excessive eye blinking 19.81 11.31 21 167066 1680 79575621
Heat stroke 19.79 11.31 21 167066 1682 79575619
Coronary artery occlusion 19.76 11.31 4 167083 15311 79561990
Hepatotoxicity 19.72 11.31 179 166908 51173 79526128
Breast tenderness 19.62 11.31 24 167063 2244 79575057
Ear infection 19.62 11.31 26 167061 34406 79542895
Tumour lysis syndrome 19.61 11.31 13 167074 23926 79553375
Leukocytosis 19.60 11.31 157 166930 43298 79534003
Diabetic hyperosmolar coma 19.60 11.31 15 167072 782 79576519
Musculoskeletal chest pain 19.55 11.31 14 167073 24750 79552551
Product packaging issue 19.53 11.31 18 167069 1215 79576086
Laboratory test abnormal 19.48 11.31 18 167069 28030 79549271
Post procedural complication 19.44 11.31 13 167074 23816 79553485
Abscess 19.44 11.31 12 167075 22939 79554362
Surgery 19.44 11.31 24 167063 32742 79544559
Myocarditis septic 19.42 11.31 6 167081 36 79577265
Orthostatic intolerance 19.37 11.31 22 167065 1902 79575399
Cerebrovascular accident 19.31 11.31 220 166867 155072 79422229
Antidiuretic hormone abnormality 19.29 11.31 7 167080 73 79577228
Body mass index increased 19.28 11.31 22 167065 1911 79575390
Myelodysplastic syndrome 19.26 11.31 21 167066 30280 79547021
Skin cancer 19.26 11.31 4 167083 15036 79562265
Road traffic accident 19.24 11.31 39 167048 43625 79533676
Skin necrosis 19.08 11.31 7 167080 18080 79559221
Product leakage 19.05 11.31 16 167071 954 79576347
Neutrophil count increased 19.04 11.31 116 166971 29280 79548021
Obsessive-compulsive personality disorder 19.02 11.31 8 167079 127 79577174
Sputum discoloured 18.93 11.31 11 167076 21732 79555569
Injection site warmth 18.83 11.31 4 167083 14803 79562498
Skin lesion 18.76 11.31 37 167050 41807 79535494
Endocarditis fibroplastica 18.71 11.31 5 167082 16 79577285
Dysphonia 18.70 11.31 59 167028 56813 79520488
Exostosis 18.69 11.31 6 167081 16852 79560449
Delusional perception 18.68 11.31 11 167076 369 79576932
Product administered to patient of inappropriate age 18.61 11.31 38 167049 5515 79571786
Psychotic disorder due to a general medical condition 18.58 11.31 10 167077 281 79577020
Dermatosis 18.55 11.31 13 167074 591 79576710
CADASIL 18.51 11.31 6 167081 43 79577258
Eye pruritus 18.49 11.31 10 167077 20560 79556741
Illness 18.47 11.31 44 167043 46467 79530834
Tonic convulsion 18.41 11.31 23 167064 2197 79575104
Oppositional defiant disorder 18.37 11.31 12 167075 485 79576816
Thermal burn 18.35 11.31 44 167043 7116 79570185
Lymphocyte count abnormal 18.30 11.31 19 167068 1484 79575817
Ageusia 18.30 11.31 6 167081 16626 79560675
Procedural complication 18.29 11.31 47 167040 7936 79569365
Cyclothymic disorder 18.28 11.31 9 167078 209 79577092
Transfusion 18.28 11.31 11 167076 21319 79555982
Dermatillomania 18.21 11.31 9 167078 211 79577090
Flashback 18.17 11.31 10 167077 294 79577007
Colitis ischaemic 18.17 11.31 72 167015 15287 79562014
Asphyxia 18.16 11.31 60 167027 11660 79565641
General physical health deterioration 18.14 11.31 727 166360 274511 79302790
Tendonitis 18.13 11.31 14 167073 23816 79553485
Optic nerve injury 18.13 11.31 13 167074 613 79576688
Aspiration 18.11 11.31 87 167000 20071 79557230
Skin pressure mark 18.05 11.31 7 167080 89 79577212
Intracranial pressure increased 18.05 11.31 48 167039 8274 79569027
Mass 18.03 11.31 7 167080 17465 79559836
Foot fracture 17.92 11.31 12 167075 21969 79555332
Respiratory tract infection 17.84 11.31 48 167039 48641 79528660
Agranulocytosis 17.82 11.31 158 166929 44872 79532429
Hepatitis C virus test positive 17.74 11.31 11 167076 406 79576895
Sinus arrhythmia 17.73 11.31 22 167065 2088 79575213
Gender dysphoria 17.72 11.31 6 167081 50 79577251
Skin infection 17.72 11.31 8 167079 18237 79559064
Electrocardiogram QT interval abnormal 17.69 11.31 10 167077 310 79576991
Infusion site pain 17.69 11.31 4 167083 14172 79563129
Peripheral sensory neuropathy 17.68 11.31 3 167084 13030 79564271
Neglect of personal appearance 17.67 11.31 8 167079 153 79577148
Tuberculosis 17.59 11.31 5 167082 15193 79562108
Hepatic cytolysis 17.49 11.31 107 166980 27044 79550257
Blood sodium increased 17.48 11.31 34 167053 4764 79572537
Schizoaffective disorder bipolar type 17.39 11.31 9 167078 233 79577068
Neurological symptom 17.39 11.31 49 167038 8734 79568567
Poor personal hygiene 17.39 11.31 12 167075 532 79576769
Hernia 17.33 11.31 7 167080 17052 79560249
Somatic dysfunction 17.29 11.31 5 167082 23 79577278
Upper limb fracture 17.26 11.31 8 167079 17959 79559342
Rhinalgia 17.25 11.31 23 167064 2344 79574957
Feelings of worthlessness 17.23 11.31 12 167075 540 79576761
Regurgitation 17.20 11.31 25 167062 2762 79574539
Blood calcium decreased 17.15 11.31 25 167062 31794 79545507
Onychophagia 17.13 11.31 7 167080 103 79577198
Painful erection 17.12 11.31 8 167079 165 79577136
Musculoskeletal disorder 17.10 11.31 12 167075 21436 79555865
Transient ischaemic attack 17.09 11.31 55 167032 52640 79524661
Visual acuity reduced 17.05 11.31 22 167065 29447 79547854
Imprisonment 17.02 11.31 12 167075 551 79576750
High density lipoprotein decreased 16.98 11.31 33 167054 4622 79572679
Gastric ulcer 16.98 11.31 28 167059 33877 79543424
Immobile 16.96 11.31 42 167045 6931 79570370
Swelling face 16.96 11.31 84 167003 71128 79506173
Paraesthesia oral 16.93 11.31 11 167076 20460 79556841
Rash erythematous 16.91 11.31 63 167024 57706 79519595
Pancytopenia 16.84 11.31 245 166842 165500 79411801
Malignant melanoma 16.78 11.31 5 167082 14736 79562565
Lung infiltration 16.76 11.31 14 167073 22898 79554403
Pulmonary haemorrhage 16.74 11.31 5 167082 14712 79562589
Paraphilia 16.67 11.31 6 167081 61 79577240
Merycism 16.66 11.31 9 167078 255 79577046
Enterococcal infection 16.62 11.31 6 167081 15654 79561647
Rapid eye movement sleep behaviour disorder 16.62 11.31 11 167076 455 79576846
Somatic delusion 16.54 11.31 13 167074 705 79576596
Rash papular 16.52 11.31 13 167074 21903 79555398
Lymphoma 16.43 11.31 8 167079 17452 79559849
Kidney infection 16.42 11.31 13 167074 21838 79555463
Cholecystitis acute 16.38 11.31 4 167083 13447 79563854
Corneal reflex decreased 16.37 11.31 10 167077 359 79576942
Accidental exposure to product by child 16.27 11.31 25 167062 2901 79574400
Encephalitis autoimmune 16.27 11.31 22 167065 2272 79575029
Pulse abnormal 16.19 11.31 27 167060 3357 79573944
Camptocormia 16.16 11.31 11 167076 477 79576824
Progressive supranuclear palsy 16.10 11.31 7 167080 121 79577180
Brain contusion 16.08 11.31 17 167070 1356 79575945
Electrocardiogram T wave amplitude decreased 16.04 11.31 13 167074 737 79576564
Lip swelling 16.01 11.31 39 167048 40872 79536429
Hypoventilation 16.00 11.31 42 167045 7182 79570119
Creatinine renal clearance decreased 16.00 11.31 10 167077 18992 79558309
Cardiac disorder 15.99 11.31 77 167010 65680 79511621
Hypoacusis 15.95 11.31 24 167063 30126 79547175
Hypotonic urinary bladder 15.93 11.31 6 167081 70 79577231
Tooth abscess 15.91 11.31 7 167080 16203 79561098
Feminisation acquired 15.91 11.31 5 167082 32 79577269
Neutropenic sepsis 15.87 11.31 20 167067 27044 79550257
Acanthosis nigricans 15.86 11.31 8 167079 196 79577105
Hepatic enzyme increased 15.85 11.31 278 166809 182332 79394969
Hypoxic-ischaemic encephalopathy 15.85 11.31 44 167043 7776 79569525
Dyslalia 15.73 11.31 15 167072 1057 79576244
Gastritis 15.63 11.31 50 167037 47943 79529358
Eye infection 15.62 11.31 3 167084 11917 79565384
Renal failure 15.57 11.31 312 166775 200656 79376645
Feeling of despair 15.54 11.31 24 167063 2797 79574504
Nephropathy toxic 15.53 11.31 12 167075 20407 79556894
Hysterical psychosis 15.51 11.31 3 167084 0 79577301
Drug abuser 15.46 11.31 37 167050 5976 79571325
Myopathy toxic 15.42 11.31 15 167072 1083 79576218
Haematuria 15.38 11.31 83 167004 68753 79508548
Photosensitivity reaction 15.34 11.31 13 167074 21114 79556187
Brief psychotic disorder with marked stressors 15.34 11.31 9 167078 300 79577001
Vasculitis 15.30 11.31 18 167069 25084 79552217
Athetosis 15.27 11.31 7 167080 138 79577163
Injection site urticaria 15.26 11.31 4 167083 12822 79564479
Right ventricular failure 15.25 11.31 16 167071 23481 79553820
Abdominal pain lower 15.22 11.31 27 167060 31755 79545546
Gallbladder disorder 15.18 11.31 11 167076 19329 79557972
Ischaemic gastritis 15.16 11.31 4 167083 12 79577289
Mixed delusion 15.16 11.31 4 167083 12 79577289
Head banging 15.13 11.31 11 167076 530 79576771
Klebsiella infection 15.10 11.31 7 167080 15713 79561588
Respiratory muscle weakness 15.02 11.31 9 167078 312 79576989
Angina unstable 14.91 11.31 8 167079 16519 79560782
Tooth fracture 14.90 11.31 3 167084 11527 79565774
Hypersomnia 14.88 11.31 91 166996 22995 79554306
Ventricular extrasystoles 14.88 11.31 81 167006 19623 79557678
Appendicitis 14.85 11.31 13 167074 20781 79556520
Posterior reversible encephalopathy syndrome 14.81 11.31 20 167067 26261 79551040
Poor venous access 14.67 11.31 10 167077 18139 79559162
Electrocardiogram QT interval 14.67 11.31 8 167079 231 79577070
Metastases to central nervous system 14.66 11.31 8 167079 16367 79560934
Neutrophil count decreased 14.66 11.31 126 166961 93833 79483468
Coronary artery stenosis 14.65 11.31 4 167083 12480 79564821
Thought blocking 14.64 11.31 8 167079 232 79577069
Drug ineffective for unapproved indication 14.60 11.31 168 166919 51070 79526231
Product complaint 14.54 11.31 61 167026 13288 79564013
Odynophagia 14.53 11.31 3 167084 11324 79565977
Tongue biting 14.53 11.31 20 167067 2101 79575200
Blood pressure abnormal 14.51 11.31 9 167078 17160 79560141
Secondary tic 14.48 11.31 4 167083 15 79577286
Cataract cortical 14.46 11.31 6 167081 92 79577209
Disability 14.43 11.31 9 167078 17111 79560190
Optic atrophy 14.42 11.31 19 167068 1914 79575387
Hypoosmolar state 14.37 11.31 9 167078 338 79576963
Live birth 14.28 11.31 11 167076 18733 79558568
Huntington's disease 14.28 11.31 4 167083 16 79577285
Upper gastrointestinal haemorrhage 14.27 11.31 42 167045 41338 79535963
Limb injury 14.22 11.31 25 167062 29503 79547798
Premature delivery 14.12 11.31 17 167070 23450 79553851
Atelectasis 14.05 11.31 29 167058 32228 79545073
Saccadic eye movement 14.05 11.31 7 167080 167 79577134
Immune system disorder 13.99 11.31 3 167084 11026 79566275
Secretion discharge 13.95 11.31 7 167080 15015 79562286
Obstructive airways disorder 13.95 11.31 28 167059 31431 79545870
Product prescribing issue 13.94 11.31 28 167059 4017 79573284
Decreased activity 13.91 11.31 45 167042 8649 79568652
Hiatus hernia 13.91 11.31 17 167070 23295 79554006
Tongue paralysis 13.90 11.31 10 167077 474 79576827
Hypoprolactinaemia 13.90 11.31 4 167083 18 79577283
Shock haemorrhagic 13.78 11.31 13 167074 20047 79557254
Fear 13.76 11.31 86 167001 21900 79555401
Congestive cardiomyopathy 13.75 11.31 55 167032 11725 79565576
Disruptive mood dysregulation disorder 13.72 11.31 4 167083 19 79577282
Affective ambivalence 13.72 11.31 4 167083 19 79577282
Inadequate diet 13.68 11.31 8 167079 265 79577036
Bulbar palsy 13.65 11.31 8 167079 266 79577035
Cyanosis 13.63 11.31 95 166992 25087 79552214
Cardiovascular symptom 13.62 11.31 5 167082 54 79577247
Coagulopathy 13.57 11.31 35 167052 35971 79541330
Derealisation 13.54 11.31 17 167070 1632 79575669
Atrioventricular block first degree 13.54 11.31 57 167030 12434 79564867
Slow speech 13.54 11.31 21 167066 2457 79574844
Infective pulmonary exacerbation of cystic fibrosis 13.51 11.31 5 167082 12846 79564455
Libido disorder 13.49 11.31 8 167079 272 79577029
Dermatitis artefacta 13.44 11.31 3 167084 3 79577298
Thought withdrawal 13.44 11.31 3 167084 3 79577298
Propulsive gait 13.44 11.31 3 167084 3 79577298
Petit mal epilepsy 13.41 11.31 34 167053 5693 79571608
Progressive multifocal leukoencephalopathy 13.40 11.31 14 167073 20586 79556715
Post procedural haemorrhage 13.39 11.31 6 167081 13738 79563563
Oesophageal food impaction 13.31 11.31 9 167078 386 79576915
Epileptic psychosis 13.30 11.31 5 167082 58 79577243
Haematotoxicity 13.30 11.31 8 167079 15511 79561790
Cytotoxic oedema 13.26 11.31 9 167078 388 79576913
Palpitations 13.26 11.31 186 166901 126424 79450877
Upper-airway cough syndrome 13.25 11.31 4 167083 11689 79565612
Product prescribing error 13.25 11.31 148 166939 44665 79532636
Feeling cold 13.23 11.31 25 167062 28704 79548597
Tinnitus 13.21 11.31 48 167039 44285 79533016
Joint effusion 13.18 11.31 11 167076 18003 79559298
Cerebral haemorrhage 13.18 11.31 69 167018 57604 79519697
Staphylococcal infection 13.18 11.31 70 167017 58225 79519076
Blood pressure diastolic increased 13.18 11.31 7 167080 14535 79562766
Muscle contracture 13.17 11.31 20 167067 2297 79575004
Drug dependence 13.15 11.31 137 166950 40632 79536669
Fat redistribution 13.14 11.31 6 167081 117 79577184
Hip fracture 13.11 11.31 28 167059 30733 79546568
Benign prostatic hyperplasia 13.11 11.31 4 167083 11608 79565693
Genital hypoaesthesia 13.10 11.31 7 167080 194 79577107
Blood parathyroid hormone decreased 13.09 11.31 3 167084 10533 79566768
Trisomy 21 13.08 11.31 5 167082 61 79577240
Hepatic cancer 13.08 11.31 3 167084 10526 79566775
Pulmonary oedema 13.04 11.31 120 166967 88134 79489167
Breast engorgement 13.01 11.31 5 167082 62 79577239
Caffeine consumption 12.98 11.31 3 167084 4 79577297
Inferiority complex 12.98 11.31 3 167084 4 79577297
Pemphigoid 12.97 11.31 65 167022 15250 79562051
Joint injury 12.96 11.31 29 167058 31306 79545995
Laryngeal dyspnoea 12.95 11.31 8 167079 293 79577008
Multiple allergies 12.95 11.31 3 167084 10457 79566844
Bronchospasm 12.95 11.31 20 167067 24839 79552462
Educational problem 12.92 11.31 9 167078 405 79576896
Heart rate irregular 12.91 11.31 31 167056 32648 79544653
Xanthoma 12.90 11.31 7 167080 200 79577101
Arrhythmia 12.88 11.31 190 166897 61082 79516219
Adjusted calcium increased 12.86 11.31 5 167082 64 79577237
Bruxism 12.85 11.31 27 167060 3999 79573302
Polyserositis 12.84 11.31 11 167076 674 79576627
Growth retardation 12.83 11.31 18 167069 1925 79575376
Accidental death 12.80 11.31 28 167059 4263 79573038
Blood potassium decreased 12.80 11.31 52 167035 46460 79530841
Pelvic pain 12.79 11.31 6 167081 13375 79563926
Femur fracture 12.78 11.31 40 167047 38612 79538689
Red blood cell elliptocytes present 12.75 11.31 7 167080 205 79577096
Pneumonia bacterial 12.73 11.31 13 167074 19318 79557983
Sperm concentration decreased 12.72 11.31 5 167082 66 79577235
Nasal polyps 12.71 11.31 39 167048 7288 79570013
Spontaneous penile erection 12.70 11.31 6 167081 127 79577174
Electrocardiogram T wave inversion 12.69 11.31 32 167055 5340 79571961
Gait inability 12.64 11.31 72 167015 58845 79518456
Orthostatic hypotension 12.53 11.31 176 166911 55988 79521313
Antisocial personality disorder 12.52 11.31 5 167082 69 79577232
Crying 12.52 11.31 87 167000 22956 79554345
Social anxiety disorder 12.43 11.31 10 167077 561 79576740
Brief psychotic disorder, with postpartum onset 12.42 11.31 4 167083 28 79577273
Negative thoughts 12.42 11.31 15 167072 1384 79575917
Libido increased 12.42 11.31 18 167069 1983 79575318
Drug withdrawal convulsions 12.39 11.31 19 167068 2201 79575100
Peritonitis 12.39 11.31 25 167062 28011 79549290
Walking aid user 12.39 11.31 3 167084 10145 79567156
Pituitary tumour 12.35 11.31 14 167073 1208 79576093
Hyperthermia malignant 12.29 11.31 22 167065 2895 79574406
Eczema 12.29 11.31 44 167043 40774 79536527
Myopathy 12.26 11.31 15 167072 20548 79556753
Orthopnoea 12.25 11.31 3 167084 10070 79567231
Blood creatinine increased 12.23 11.31 240 166847 154817 79422484
Ornithine transcarbamoylase deficiency 12.23 11.31 3 167084 6 79577295
Macroprolactinaemia 12.23 11.31 3 167084 6 79577295
Blood urine present 12.22 11.31 16 167071 21281 79556020
Cholelithiasis 12.14 11.31 166 166921 52498 79524803
Cardiac output decreased 12.09 11.31 17 167070 1821 79575480
Prescribed overdose 12.07 11.31 127 166960 37756 79539545
Renal cyst 12.07 11.31 8 167079 14724 79562577
Shock 12.06 11.31 142 166945 43406 79533895
Pulmonary vein occlusion 12.05 11.31 6 167081 143 79577158
Tooth extraction 12.04 11.31 4 167083 10991 79566310
Ketosis-prone diabetes mellitus 11.96 11.31 4 167083 32 79577269
Blepharospasm 11.94 11.31 33 167054 5818 79571483
Conversion disorder 11.93 11.31 17 167070 1844 79575457
Strabismus 11.91 11.31 20 167067 2501 79574800
Carpal tunnel syndrome 11.90 11.31 14 167073 19514 79557787
Hyperglycaemic hyperosmolar nonketotic syndrome 11.87 11.31 19 167068 2284 79575017
Gastrointestinal pain 11.86 11.31 3 167084 9852 79567449
Breast cancer 11.86 11.31 34 167053 33747 79543554
Immunosuppression 11.84 11.31 6 167081 12797 79564504
Wound infection 11.84 11.31 20 167067 23971 79553330
Cholangitis 11.80 11.31 6 167081 12770 79564531
Myoglobinuria 11.80 11.31 13 167074 1087 79576214
Lacrimation increased 11.79 11.31 18 167069 22459 79554842
Bone marrow failure 11.76 11.31 61 167026 51046 79526255
Xanthopsia 11.75 11.31 8 167079 347 79576954
Thought insertion 11.75 11.31 4 167083 34 79577267
Injection site mass 11.75 11.31 15 167072 20169 79557132
Substance use 11.72 11.31 12 167075 922 79576379
Autoimmune hepatitis 11.71 11.31 5 167082 11778 79565523
Asocial behaviour 11.69 11.31 5 167082 83 79577218
Prescribed underdose 11.66 11.31 28 167059 29486 79547815
Hyponatraemic syndrome 11.61 11.31 11 167076 769 79576532
Hallucination, olfactory 11.60 11.31 9 167078 479 79576822
Bedridden 11.49 11.31 53 167034 12026 79565275
Hepatic failure 11.47 11.31 78 167009 61134 79516167
Sarcoidosis 11.46 11.31 41 167046 8294 79569007
Spinal shock 11.45 11.31 4 167083 37 79577264
Oesophageal achalasia 11.44 11.31 11 167076 783 79576518
Throat tightness 11.40 11.31 26 167061 27881 79549420
Bulimia nervosa 11.37 11.31 7 167080 255 79577046
Injection site haemorrhage 11.36 11.31 26 167061 27844 79549457
Endocarditis 11.35 11.31 4 167083 10593 79566708

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 31.30 27.29 12 405 61 89314

Pharmacologic Action:

SourceCodeDescription
ATC N05AX08 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Other antipsychotics
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:35471 psychotropic drugs
CHEBI has role CHEBI:37890 alpha-adrenergic receptor blockaders
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Infantile autism indication 408857007
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Depression Treatment Adjunct off-label use
Priapism contraindication 6273006 DOID:9286
Suicidal thoughts contraindication 6471006
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Dysphagia contraindication 40739000
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Hyperlipidemia contraindication 55822004 DOID:1168
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Substance abuse contraindication 66214007
Diabetes mellitus contraindication 73211009 DOID:9351
Diffuse Lewy body disease contraindication 80098002
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Cerebrovascular accident contraindication 230690007
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Retention of urine contraindication 267064002
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Fever contraindication 386661006
Hypothermia contraindication 386689009
Impaired cognition contraindication 386806002
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Predisposed to Torsades de Pointes Cardiac Arrhythmias contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.78 Basic
pKa2 3.45 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
100MG/0.28ML (100MG/0.28ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
125MG/0.35ML (125MG/0.35ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
150MG/0.42ML (150MG/0.42ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
200MG/0.56ML (200MG/0.56ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
250MG/0.7ML (250MG/0.7ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
50MG/0.14ML (50MG/0.14ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
75MG/0.21ML (75MG/0.21ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9439905 Jan. 12, 2025 TREATMENT OF SCHIZOPHRENIA
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10406160 June 26, 2026 METHOD OF TREATING SCHIZOPHRENIA
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10406160 June 26, 2026 METHOD OF TREATING SCHIZOPHRENIA
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10058554 Sept. 26, 2026 ADMINISTRATION OF RISPERIDONE
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10058554 Sept. 26, 2026 ADMINISTRATION OF RISPERIDONE
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 11110093 Nov. 5, 2026 TREATING SCHIZOPHRENIA
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 11110093 Nov. 5, 2026 TREATING SCHIZOPHRENIA
100MG/0.28ML (100MG/0.28ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
100MG/0.28ML (100MG/0.28ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
125MG/0.35ML (125MG/0.35ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
125MG/0.35ML (125MG/0.35ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
150MG/0.42ML (150MG/0.42ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
150MG/0.42ML (150MG/0.42ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
200MG/0.56ML (200MG/0.56ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
200MG/0.56ML (200MG/0.56ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
250MG/0.7ML (250MG/0.7ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
250MG/0.7ML (250MG/0.7ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
50MG/0.14ML (50MG/0.14ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
50MG/0.14ML (50MG/0.14ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
75MG/0.21ML (75MG/0.21ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8221778 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
75MG/0.21ML (75MG/0.21ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 8741327 Nov. 12, 2027 TREATMENT OF SCHIZOPHRENIA
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10376590 Feb. 13, 2028 METHOD OF TREATING SCHIZOPHRENIA
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 11013809 Feb. 13, 2028 TREATING SCHIZOPHRENIA
120MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9186413 Feb. 13, 2028 TREATMENT OF SCHIZOPHRENIA
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 10376590 Feb. 13, 2028 METHOD OF TREATING SCHIZOPHRENIA
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 11013809 Feb. 13, 2028 TREATING SCHIZOPHRENIA
90MG PERSERIS KIT INDIVIOR N210655 July 27, 2018 RX FOR SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS 9186413 Feb. 13, 2028 TREATMENT OF SCHIZOPHRENIA
12.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10098882 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
12.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10406161 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
12.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9446135 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
12.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9532991 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
25MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10098882 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
25MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10406161 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
25MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9446135 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
25MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9532991 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
37.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10098882 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
37.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10406161 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
37.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9446135 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
37.5MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9532991 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
50MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10098882 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
50MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10406161 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
50MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9446135 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS
50MG RYKINDO SHANDONG LUYE N212849 Jan. 13, 2023 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 9532991 April 10, 2032 TREATMENT OF SCHIZOPHRENIA IN ADULTS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
100MG/0.28ML (100MG/0.28ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
125MG/0.35ML (125MG/0.35ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
150MG/0.42ML (150MG/0.42ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
200MG/0.56ML (200MG/0.56ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
250MG/0.7ML (250MG/0.7ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
50MG/0.14ML (50MG/0.14ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT
75MG/0.21ML (75MG/0.21ML) UZEDY TEVA N213586 April 28, 2023 RX SUSPENSION, EXTENDED RELEASE SUBCUTANEOUS April 28, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 9.36 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.49 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 7.68 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 8 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.37 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.79 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.44 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.42 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.70 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.65 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.47 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.55 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.77 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.07 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.02 PDSP
Histamine H1 receptor GPCR Ki 7.48 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.92 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.55 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 5.43 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.54 PDSP
5-hydroxytryptamine receptor 1B GPCR ANTAGONIST Ki 7.49 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 7.60 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 8.50 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 5.28 DRUG MATRIX
D(4) dopamine receptor GPCR ANTAGONIST Ki 8 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.40 IUPHAR
Alpha-1B adrenergic receptor GPCR Ki 8.48 WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel EC50 6.49 CHEMBL
5-hydroxytryptamine receptor 5A GPCR Ki 6.69 WOMBAT-PK
5-hydroxytryptamine receptor 1F GPCR ANTAGONIST Ki 5.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR ANTAGONIST Ki 5.90 IUPHAR
Histamine H3 receptor GPCR Ki 5.96 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 4.96 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.80 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Histone H1.0 Nuclear other Ki 7.85 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 8.97 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 7.89 CHEMBL
Histamine H1 receptor GPCR Ki 7.66 CHEMBL
D(2) dopamine receptor GPCR Ki 8.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.89 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 9.82 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.85 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.66 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.66 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.60 CHEMBL
D(2) dopamine receptor GPCR IC50 7.64 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 7.84 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 6.37 CHEMBL
Histamine H1 receptor GPCR IC50 7.10 CHEMBL
D(3) dopamine receptor GPCR Ki 8.01 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 6.40 IUPHAR
Transporter Transporter Ki 4.55 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.47 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 9.85 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 8.82 CHEMBL

External reference:

IDSource
4020840 VUID
N0000148350 NUI
D00426 KEGG_DRUG
4020840 VANDF
C0073393 UMLSCUI
CHEBI:8871 CHEBI
CHEMBL85 ChEMBL_ID
D018967 MESH_DESCRIPTOR_UI
DB00734 DRUGBANK_ID
5073 PUBCHEM_CID
96 IUPHAR_LIGAND_ID
6085 INN_ID
L6UH7ZF8HC UNII
152318 RXNORM
1259 MMSL
146973 MMSL
5429 MMSL
d03180 MMSL
004392 NDDF
108386000 SNOMEDCT_US
386840002 SNOMEDCT_US
8NU PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0054-0063 SOLUTION 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0054-0063 SOLUTION 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0054-0063 SOLUTION 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8196 TABLET 0.25 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8196 TABLET 0.25 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8196 TABLET 0.25 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8197 TABLET 0.50 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8197 TABLET 0.50 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8197 TABLET 0.50 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8198 TABLET 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8198 TABLET 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8198 TABLET 1 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8265 TABLET 3 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8265 TABLET 3 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8265 TABLET 3 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8288 TABLET 2 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8288 TABLET 2 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8288 TABLET 2 mg ORAL ANDA 33 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6357 TABLET 0.25 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6357 TABLET 0.25 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6358 TABLET 0.50 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6358 TABLET 0.50 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6359 TABLET 1 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6359 TABLET 1 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6360 TABLET 2 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6360 TABLET 2 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6361 TABLET 3 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6361 TABLET 3 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6362 TABLET 4 mg ORAL ANDA 30 sections
Risperidone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6362 TABLET 4 mg ORAL ANDA 30 sections