quinagolide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| dopamine receptor agonists, ergoline derivatives | 2339 | 87056-78-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 75 | mcg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G02CB04 | GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS OTHER GYNECOLOGICALS Prolactine inhibitors |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018491 | Dopamine Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.45 | acidic |
| pKa2 | 11.15 | acidic |
| pKa3 | 8.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Serotonin (5-HT) receptor | GPCR | IC50 | 5.64 | CHEMBL | |||||
| Adrenergic receptor alpha-2 | GPCR | IC50 | 5.25 | CHEMBL | |||||
| Dopamine receptor | GPCR | IC50 | 7.72 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | IC50 | 5.22 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07217 | KEGG_DRUG |
| C0256089 | UMLSCUI |
| CHEBI:135627 | CHEBI |
| CHEMBL2218861 | ChEMBL_ID |
| CHEMBL290962 | ChEMBL_ID |
| DB09097 | DRUGBANK_ID |
| C046650 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3086400 | PUBCHEM_CID |
| 6545 | INN_ID |
| 80Q9QWN15M | UNII |
| 152131 | RXNORM |
| 005470 | NDDF |
| 326066005 | SNOMEDCT_US |
| 395850005 | SNOMEDCT_US |
Pharmaceutical products:
None