propyphenazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 2309 479-92-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • yoshipyrin
  • propyphenazone
  • isopropchin
  • isopropylantipyrin
  • isopropylantipyrine
  • isopropylphenazone
  • isopropyrine
  • propyfenazone
  • propifenazone
  • Molecular weight: 230.31
  • Formula: C14H18N2O
  • CLOGP: 1.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -1.40
  • ROTB: 2

Drug dosage:

DoseUnitRoute
3 g R
3 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BB04 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB54 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
ATC N02BB74 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Pyrazolones
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:49110 peripheral nervous system drugs

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel BLOCKER IC50 4.48 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D01380 KEGG_DRUG
C0072245 UMLSCUI
CHEBI:135538 CHEBI
CHEMBL28318 ChEMBL_ID
DB13524 DRUGBANK_ID
3778 PUBCHEM_CID
2848 INN_ID
C009077 MESH_SUPPLEMENTAL_RECORD_UI
OED8FV75PY UNII
34710 RXNORM
d06973 MMSL
004365 NDDF
699188007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GEWORIN HUMAN OTC DRUG LABEL 3 72689-0019 TABLET 150 mg ORAL OTC monograph not final 7 sections