propofol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2302 2078-54-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propofol
  • ampofol
  • diprivan
  • disoprofol
  • pofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
  • Molecular weight: 178.28
  • Formula: C12H18O
  • CLOGP: 3.93
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -3.05
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.02 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 4.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1989 FDA FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 2837.85 15.90 910 39973 22723 63425416
Anaphylactic reaction 1182.70 15.90 655 40228 65445 63382694
Hypotension 964.59 15.90 1023 39860 271581 63176558
Cardiac arrest 853.47 15.90 602 40281 91943 63356196
Bronchospasm 773.89 15.90 322 40561 16958 63431181
Propofol infusion syndrome 753.90 15.90 165 40718 818 63447321
Serotonin syndrome 465.42 15.90 267 40616 28415 63419724
Tachycardia 418.73 15.90 445 40438 117711 63330428
Circulatory collapse 404.18 15.90 222 40661 21716 63426423
Bradycardia 401.88 15.90 351 40532 72876 63375263
Stress cardiomyopathy 385.91 15.90 165 40718 9285 63438854
Delayed recovery from anaesthesia 383.81 15.90 91 40792 680 63447459
Hyperthermia malignant 330.95 15.90 82 40801 752 63447387
Fatigue 325.82 15.90 86 40797 887942 62560197
Respiratory depression 324.26 15.90 164 40719 13551 63434588
Drug interaction 298.37 15.90 531 40352 228600 63219539
Status epilepticus 291.21 15.90 158 40725 15075 63433064
Arthralgia 270.83 15.90 27 40856 569683 62878456
Multiple organ dysfunction syndrome 265.91 15.90 249 40634 56503 63391636
Ventricular tachycardia 264.03 15.90 163 40720 19816 63428323
Neuromuscular block prolonged 244.07 15.90 59 40824 483 63447656
Ventricular fibrillation 226.57 15.90 123 40760 11744 63436395
Oxygen saturation decreased 224.73 15.90 281 40602 88304 63359835
Diarrhoea 220.51 15.90 93 40790 715273 62732866
Shock 218.88 15.90 154 40729 23309 63424830
Metabolic acidosis 215.44 15.90 200 40683 44869 63403270
Haemodynamic instability 211.70 15.90 108 40775 9082 63439057
Myoglobin urine present 209.09 15.90 56 40827 716 63447423
Blood pressure decreased 195.63 15.90 225 40658 64797 63383342
Joint swelling 191.66 15.90 4 40879 327662 63120477
Procedural hypotension 185.13 15.90 56 40827 1134 63447005
Blood creatine phosphokinase increased 181.25 15.90 153 40730 30277 63417862
Apnoea 181.08 15.90 93 40790 7929 63440210
Alopecia 180.23 15.90 9 40874 337527 63110612
Pulseless electrical activity 177.94 15.90 90 40793 7431 63440708
Rhabdomyolysis 176.05 15.90 177 40706 43774 63404365
Drug intolerance 175.81 15.90 5 40878 308656 63139483
Unwanted awareness during anaesthesia 174.01 15.90 41 40842 297 63447842
Anaesthetic complication 169.14 15.90 59 40824 1901 63446238
Myoclonus 157.00 15.90 108 40775 15760 63432379
Diabetes insipidus 155.90 15.90 60 40823 2565 63445574
Fall 155.12 15.90 32 40851 392302 63055837
Dystonia 153.36 15.90 101 40782 13718 63434421
Type I hypersensitivity 149.26 15.90 60 40823 2882 63445257
Abdominal discomfort 147.61 15.90 17 40866 320868 63127271
Headache 145.73 15.90 117 40766 633124 62815015
Hypoxia 145.72 15.90 186 40697 59606 63388533
Electrocardiogram ST segment elevation 145.37 15.90 64 40819 3863 63444276
Pain 142.31 15.90 161 40722 740467 62707672
Labile blood pressure 139.71 15.90 50 40833 1739 63446400
Post procedural complication 138.54 15.90 103 40780 16971 63431168
Anaphylactoid shock 138.07 15.90 34 40849 303 63447836
Generalised tonic-clonic seizure 133.31 15.90 126 40757 28890 63419249
Cardio-respiratory arrest 132.88 15.90 178 40705 59781 63388358
Nasopharyngitis 131.87 15.90 8 40875 254249 63193890
Rheumatoid arthritis 128.64 15.90 9 40874 253810 63194329
Amylase increased 127.35 15.90 68 40815 6277 63441862
Respiratory acidosis 126.50 15.90 69 40814 6646 63441493
Arthropathy 126.09 15.90 6 40877 234786 63213353
Torsade de pointes 123.03 15.90 87 40796 13264 63434875
Toxic encephalopathy 122.27 15.90 67 40816 6512 63441627
Airway complication of anaesthesia 120.68 15.90 28 40855 188 63447951
Malaise 120.12 15.90 59 40824 415895 63032244
Procedural complication 119.71 15.90 62 40821 5377 63442762
Sinusitis 117.93 15.90 7 40876 226646 63221493
Unresponsive to stimuli 117.10 15.90 126 40757 33690 63414449
Anticholinergic syndrome 115.41 15.90 47 40836 2335 63445804
Product dose omission issue 113.99 15.90 10 40873 234303 63213836
Systemic lupus erythematosus 113.27 15.90 5 40878 208913 63239226
Peripheral swelling 112.99 15.90 18 40865 265924 63182215
Multiple-drug resistance 111.11 15.90 58 40825 5112 63443027
Laryngospasm 110.96 15.90 49 40834 2979 63445160
Anaphylactoid reaction 110.43 15.90 52 40831 3671 63444468
Pain in extremity 108.54 15.90 39 40844 331447 63116692
Kounis syndrome 107.96 15.90 41 40842 1689 63446450
Dizziness 105.72 15.90 74 40809 429851 63018288
Weight increased 105.65 15.90 20 40863 260772 63187367
Clonus 105.36 15.90 54 40829 4582 63443557
Respiratory failure 104.93 15.90 214 40669 101644 63346495
Tryptase increased 104.75 15.90 28 40855 355 63447784
Hypoventilation 104.08 15.90 54 40829 4700 63443439
Cardiogenic shock 102.34 15.90 88 40795 17844 63430295
Encephalopathy 101.83 15.90 125 40758 38495 63409644
Arteriospasm coronary 101.28 15.90 50 40833 3918 63444221
Infusion related reaction 101.23 15.90 18 40865 245503 63202636
Premature delivery 99.91 15.90 110 40773 30171 63417968
Swelling 99.79 15.90 27 40856 275351 63172788
Troponin increased 98.03 15.90 68 40815 10053 63438086
Seizure 96.80 15.90 243 40640 132391 63315748
Allergy test negative 95.94 15.90 23 40860 181 63447958
Acute generalised exanthematous pustulosis 94.65 15.90 69 40814 11030 63437109
Electrocardiogram QT prolonged 94.50 15.90 151 40732 59379 63388760
Nausea 94.11 15.90 263 40620 854208 62593931
Mitochondrial DNA mutation 92.87 15.90 26 40857 396 63447743
PCO2 increased 90.65 15.90 33 40850 1206 63446933
Mydriasis 90.06 15.90 69 40814 11887 63436252
Respiratory arrest 89.87 15.90 108 40775 32537 63415602
Weight decreased 89.84 15.90 33 40850 276765 63171374
Contraindicated product administered 89.62 15.90 16 40867 217632 63230507
Intestinal ischaemia 88.78 15.90 57 40826 7411 63440728
Ventricular hypokinesia 88.25 15.90 48 40835 4596 63443543
Renal ischaemia 86.64 15.90 27 40856 606 63447533
Intra-abdominal pressure increased 86.44 15.90 22 40861 227 63447912
Product contamination 85.81 15.90 28 40855 732 63447407
Pruritus 85.19 15.90 65 40818 361388 63086751
Brain oedema 83.73 15.90 71 40812 14124 63434015
Opisthotonus 83.23 15.90 23 40860 333 63447806
Agitation 82.02 15.90 142 40741 59615 63388524
Exposure during pregnancy 81.88 15.90 253 40630 155294 63292845
Blood lactate dehydrogenase increased 81.55 15.90 87 40796 23029 63425110
Dyspnoea 80.78 15.90 193 40690 661120 62787019
Blood gases abnormal 80.52 15.90 27 40856 770 63447369
Anaesthetic complication pulmonary 79.94 15.90 16 40867 46 63448093
Discomfort 79.10 15.90 8 40875 167366 63280773
Posterior reversible encephalopathy syndrome 79.04 15.90 75 40808 17270 63430869
Pulmonary oedema 77.42 15.90 132 40751 54741 63393398
Musculoskeletal stiffness 77.25 15.90 13 40870 184605 63263534
Stridor 77.21 15.90 40 40843 3470 63444669
Hepatic ischaemia 77.15 15.90 25 40858 639 63447500
Disseminated intravascular coagulation 76.76 15.90 77 40806 18974 63429165
Wound 76.64 15.90 8 40875 163255 63284884
Transmission of an infectious agent via product 76.08 15.90 18 40865 133 63448006
Anaesthetic complication neurological 75.53 15.90 20 40863 244 63447895
Drug ineffective for unapproved indication 75.24 15.90 101 40782 33962 63414177
Insomnia 74.46 15.90 23 40860 215229 63232910
Oliguria 74.04 15.90 55 40828 9046 63439093
Laryngeal oedema 73.86 15.90 46 40837 5672 63442467
Vasoplegia syndrome 73.77 15.90 31 40852 1668 63446471
Lower respiratory tract infection 72.24 15.90 3 40880 132304 63315835
Partial seizures 70.46 15.90 45 40838 5797 63442342
Decreased appetite 70.29 15.90 37 40846 251015 63197124
Coagulopathy 70.15 15.90 76 40807 20468 63427671
Acute hepatic failure 70.05 15.90 72 40811 18255 63429884
Acute respiratory distress syndrome 69.98 15.90 81 40802 23453 63424686
Contusion 68.79 15.90 8 40875 150036 63298103
CSF oligoclonal band present 67.31 15.90 20 40863 380 63447759
Blood pH decreased 67.22 15.90 33 40850 2554 63445585
PO2 increased 66.51 15.90 24 40859 855 63447284
Sinus tachycardia 66.32 15.90 80 40803 24188 63423951
Constipation 66.22 15.90 31 40852 224912 63223227
Carcinoid crisis 65.96 15.90 18 40865 248 63447891
Pneumatosis 65.65 15.90 20 40863 415 63447724
Myoclonic epilepsy 65.09 15.90 26 40857 1228 63446911
Hepatorenal syndrome 63.57 15.90 29 40854 1903 63446236
Oculogyric crisis 63.54 15.90 28 40855 1693 63446446
Hyperreflexia 62.52 15.90 42 40841 5892 63442247
Electrocardiogram QRS complex prolonged 62.49 15.90 42 40841 5896 63442243
Renal impairment 62.46 15.90 160 40723 88195 63359944
Alanine aminotransferase increased 62.39 15.90 177 40706 103593 63344546
Stomatitis 62.11 15.90 8 40875 138717 63309422
Arthritis 62.07 15.90 3 40880 115918 63332221
Angioedema 61.96 15.90 111 40772 47854 63400285
Erythema 61.54 15.90 250 40633 175501 63272638
Hepatic failure 61.52 15.90 94 40789 35562 63412577
Endotracheal intubation complication 60.90 15.90 19 40864 428 63447711
Atrioventricular block complete 60.79 15.90 47 40836 8204 63439935
Necrosis ischaemic 59.56 15.90 22 40861 838 63447301
Neuromuscular blockade 59.42 15.90 17 40866 281 63447858
Septic shock 59.35 15.90 132 40751 66497 63381642
Coma 59.01 15.90 129 40754 64235 63383904
Ventricular extrasystoles 58.01 15.90 53 40830 11634 63436505
Gene mutation 57.98 15.90 26 40857 1639 63446500
Oxygen saturation abnormal 57.58 15.90 33 40850 3496 63444643
Dyskinesia 57.53 15.90 86 40797 31916 63416223
Maternal exposure during delivery 57.31 15.90 25 40858 1475 63446664
Muscle rigidity 56.78 15.90 52 40831 11448 63436691
Postoperative delirium 56.46 15.90 13 40870 84 63448055
Bronchitis 56.42 15.90 7 40876 124928 63323211
Blood lactic acid increased 55.81 15.90 42 40841 7044 63441095
Acute pulmonary oedema 54.79 15.90 44 40839 8114 63440025
Hepatitis acute 54.58 15.90 46 40837 9074 63439065
End-tidal CO2 decreased 54.33 15.90 10 40873 15 63448124
Hepatocellular injury 54.18 15.90 77 40806 27304 63420835
Hepatic enzyme increased 53.48 15.90 32 40851 202296 63245843
Pleocytosis 52.64 15.90 20 40863 825 63447314
Drug reaction with eosinophilia and systemic symptoms 52.55 15.90 85 40798 33751 63414388
Inappropriate schedule of product administration 51.73 15.90 4 40879 103961 63344178
Gastrointestinal disorder 51.15 15.90 11 40872 131228 63316911
Foetal death 51.02 15.90 48 40835 10932 63437207
Infection 50.46 15.90 44 40839 229129 63219010
Renal failure 49.94 15.90 178 40705 117474 63330665
Pneumonia 49.75 15.90 141 40742 456626 62991513
Acidosis hyperchloraemic 49.19 15.90 16 40867 414 63447725
Asthenia 49.08 15.90 109 40774 383495 63064644
Upper airway obstruction 48.75 15.90 18 40865 685 63447454
Gait disturbance 48.37 15.90 29 40854 183149 63264990
Hypovolaemia 48.34 15.90 46 40837 10627 63437512
Toxic epidermal necrolysis 48.30 15.90 70 40813 25264 63422875
Therapeutic product effect prolonged 47.82 15.90 15 40868 344 63447795
Post procedural haemorrhage 47.31 15.90 40 40843 7924 63440215
Influenza 46.94 15.90 7 40876 108715 63339424
Urinary tract infection 46.91 15.90 61 40822 264623 63183516
Back pain 46.69 15.90 61 40822 264084 63184055
Blood bicarbonate decreased 46.65 15.90 27 40856 2914 63445225
Fear 46.43 15.90 54 40829 15712 63432427
Unmasking of previously unidentified disease 46.40 15.90 19 40864 957 63447182
Blood potassium increased 46.22 15.90 58 40825 18251 63429888
Altered state of consciousness 45.63 15.90 68 40815 25162 63422977
Hypercapnia 44.58 15.90 33 40850 5398 63442741
Muscle relaxant therapy 43.86 15.90 12 40871 167 63447972
Shock haemorrhagic 43.59 15.90 42 40841 9853 63438286
Chest pain 43.40 15.90 45 40838 215914 63232225
Phrenic nerve paralysis 42.78 15.90 12 40871 184 63447955
Arrhythmia 42.67 15.90 83 40800 38057 63410082
Acute kidney injury 42.63 15.90 303 40580 263112 63185027
Hypertriglyceridaemia 42.55 15.90 34 40849 6225 63441914
Mental status changes postoperative 42.54 15.90 12 40871 188 63447951
Cardiovascular insufficiency 42.34 15.90 20 40863 1421 63446718
Hyperlactacidaemia 42.14 15.90 25 40858 2824 63445315
Atrioventricular block second degree 41.95 15.90 28 40855 3886 63444253
Electrocardiogram ST segment depression 41.92 15.90 25 40858 2852 63445287
Delirium 41.53 15.90 97 40786 50444 63397695
Psoriasis 41.47 15.90 4 40879 86953 63361186
Product contamination microbial 41.47 15.90 12 40871 207 63447932
Depressed level of consciousness 41.38 15.90 110 40773 61968 63386171
Suspected product quality issue 41.15 15.90 12 40871 213 63447926
Electroencephalogram abnormal 41.12 15.90 27 40856 3645 63444494
Local anaesthetic systemic toxicity 41.04 15.90 17 40866 882 63447257
Pulse absent 40.44 15.90 31 40852 5343 63442796
Abdominal pain upper 40.38 15.90 44 40839 206400 63241739
Tracheal deviation 40.35 15.90 11 40872 151 63447988
Loss of personal independence in daily activities 40.35 15.90 7 40876 97283 63350856
Hepatitis 40.22 15.90 83 40800 39705 63408434
Confusion postoperative 40.09 15.90 12 40871 234 63447905
Perforation 39.69 15.90 18 40865 1165 63446974
Injection site pain 39.56 15.90 17 40866 129783 63318356
Premature baby 39.10 15.90 57 40826 20678 63427461
Toxicity to various agents 38.61 15.90 282 40601 246968 63201171
Intentional product use issue 38.58 15.90 17 40866 127875 63320264
Malignant neoplasm progression 38.58 15.90 4 40879 82117 63366022
Procedural nausea 38.50 15.90 16 40867 837 63447302
Hepatorenal failure 38.15 15.90 15 40868 679 63447460
Brain death 38.01 15.90 25 40858 3385 63444754
Airway peak pressure increased 37.94 15.90 12 40871 283 63447856
Left ventricle outflow tract obstruction 37.90 15.90 12 40871 284 63447855
Disease progression 37.54 15.90 16 40867 122742 63325397
Change in seizure presentation 37.53 15.90 13 40870 410 63447729
Skin test positive 37.38 15.90 15 40868 717 63447422
Impaired healing 37.19 15.90 10 40873 102532 63345607
Recurrence of neuromuscular blockade 36.90 15.90 10 40873 134 63448005
Left ventricular dysfunction 36.88 15.90 42 40841 11946 63436193
Neutropenia 36.84 15.90 35 40848 174970 63273169
Wrong product administered 36.80 15.90 31 40852 6110 63442029
Neuroleptic malignant syndrome 36.69 15.90 42 40841 12014 63436125
Cardiac output decreased 36.49 15.90 16 40867 956 63447183
Herpes zoster 36.32 15.90 5 40878 82457 63365682
Paralysis 36.23 15.90 38 40845 9862 63438277
Neuropathy peripheral 36.08 15.90 14 40869 113653 63334486
Hepatic cytolysis 36.05 15.90 47 40836 15360 63432779
Irregular breathing 35.99 15.90 12 40871 336 63447803
Renal injury 35.92 15.90 37 40846 9402 63438737
Ill-defined disorder 35.90 15.90 5 40878 81750 63366389
Ultrasound ovary abnormal 35.80 15.90 9 40874 88 63448051
Feeling abnormal 35.77 15.90 26 40857 148366 63299773
Intensive care unit acquired weakness 35.71 15.90 15 40868 806 63447333
Procedural haemorrhage 35.67 15.90 22 40861 2666 63445473
Cyanosis 35.55 15.90 49 40834 16886 63431253
Phaeochromocytoma crisis 35.50 15.90 11 40872 242 63447897
Lactic acidosis 35.38 15.90 77 40806 38210 63409929
Rash maculo-papular 35.18 15.90 69 40814 31827 63416312
Stevens-Johnson syndrome 35.15 15.90 60 40823 24890 63423249
Coma scale abnormal 35.04 15.90 28 40855 5125 63443014
Systemic inflammatory response syndrome 34.98 15.90 29 40854 5592 63442547
Subcutaneous emphysema 34.94 15.90 15 40868 851 63447288
Inadequate aseptic technique in use of product 34.75 15.90 7 40876 21 63448118
Oropharyngeal pain 34.68 15.90 9 40874 94478 63353661
Hypocapnia 34.62 15.90 12 40871 379 63447760
Abdominal pain 34.61 15.90 87 40796 293369 63154770
Myocardial ischaemia 34.49 15.90 42 40841 12817 63435322
Macroglossia 34.46 15.90 14 40869 691 63447448
Procedural vomiting 34.36 15.90 13 40870 530 63447609
Acute postoperative sialadenitis 34.27 15.90 7 40876 23 63448116
Atrioventricular block first degree 34.19 15.90 32 40851 7241 63440898
Supraventricular tachycardia 34.11 15.90 44 40839 14227 63433912
Asthma 33.93 15.90 20 40863 127541 63320598
Hypoaesthesia 33.92 15.90 35 40848 168358 63279781
Sinus bradycardia 33.44 15.90 44 40839 14507 63433632
Dyspepsia 33.42 15.90 12 40871 102184 63345955
Myxoedema coma 33.37 15.90 12 40871 423 63447716
Face oedema 33.06 15.90 52 40831 20160 63427979
Haemodilution 32.98 15.90 9 40874 124 63448015
Extravasation 32.98 15.90 20 40863 2352 63445787
Procedural hypertension 32.83 15.90 11 40872 313 63447826
Eosinophilia 32.42 15.90 55 40828 22701 63425438
Injection site erythema 32.34 15.90 7 40876 83167 63364972
Mobility decreased 32.22 15.90 19 40864 121140 63326999
Tachypnoea 31.81 15.90 47 40836 17255 63430884
Laryngeal stenosis 31.79 15.90 15 40868 1063 63447076
Brain herniation 31.67 15.90 23 40860 3654 63444485
Death 31.57 15.90 129 40754 374252 63073887
Haematemesis 31.40 15.90 64 40819 30348 63417791
Depression 31.12 15.90 49 40834 196443 63251696
Respiratory distress 31.05 15.90 68 40815 33883 63414256
Hypotensive transfusion reaction 30.99 15.90 7 40876 41 63448098
Patent ductus arteriosus 30.85 15.90 24 40859 4226 63443913
Gaze palsy 30.71 15.90 16 40867 1404 63446735
Overdose 30.66 15.90 151 40732 114927 63333212
Product use issue 30.39 15.90 60 40823 220460 63227679
Trigemino-cardiac reflex 30.04 15.90 7 40876 48 63448091
Musculoskeletal pain 29.90 15.90 11 40872 92266 63355873
Blood pressure immeasurable 29.89 15.90 15 40868 1217 63446922
Ventricular dysfunction 29.75 15.90 20 40863 2808 63445331
Muscle spasms 29.74 15.90 34 40849 156116 63292023
Epilepsy with myoclonic-atonic seizures 29.67 15.90 8 40875 105 63448034
Myoglobinuria 29.66 15.90 10 40873 290 63447849
Aspartate aminotransferase increased 29.66 15.90 126 40757 90151 63357988
Vitamin K deficiency 29.53 15.90 11 40872 429 63447710
Somatosensory evoked potentials abnormal 29.40 15.90 5 40878 3 63448136
Hyperkalaemia 29.25 15.90 89 40794 54114 63394025
Allergy test positive 29.24 15.90 12 40871 608 63447531
White blood cell count decreased 29.06 15.90 28 40855 139076 63309063
Nasal congestion 28.87 15.90 4 40879 65656 63382483
Ischaemic cerebral infarction 28.64 15.90 15 40868 1331 63446808
Hypoxic-ischaemic encephalopathy 28.53 15.90 23 40860 4264 63443875
Oedema peripheral 28.39 15.90 49 40834 189462 63258677
Atrioventricular dissociation 28.27 15.90 9 40874 217 63447922
Therapeutic product effect decreased 27.99 15.90 51 40832 193136 63255003
Maternal exposure during pregnancy 27.75 15.90 239 40644 219823 63228316
Burkholderia test positive 27.55 15.90 9 40874 236 63447903
Dry mouth 27.48 15.90 8 40875 77855 63370284
Gastrooesophageal reflux disease 26.87 15.90 14 40869 95625 63352514
Dehydration 26.72 15.90 44 40839 173310 63274829
Myotonia 26.68 15.90 8 40875 157 63447982
Anhedonia 26.49 15.90 34 40849 10940 63437199
Acute lung injury 26.46 15.90 15 40868 1556 63446583
Muscle injury 26.45 15.90 5 40878 65340 63382799
Migraine 26.38 15.90 17 40866 103329 63344810
Skin test negative 26.26 15.90 5 40878 10 63448129
Hospitalisation 26.15 15.90 11 40872 85070 63363069
Electrocardiogram repolarisation abnormality 26.10 15.90 14 40869 1303 63446836
Oesophageal intramural haematoma 26.10 15.90 7 40876 90 63448049
Anaemia 26.06 15.90 99 40784 293331 63154808
Bradycardia foetal 26.01 15.90 10 40873 426 63447713
Muscle twitching 26.01 15.90 46 40837 19622 63428517
Lipoedema 25.83 15.90 9 40874 289 63447850
Chest discomfort 25.56 15.90 20 40863 109949 63338190
Coronary artery embolism 25.48 15.90 8 40875 184 63447955
Fibromyalgia 25.36 15.90 10 40873 80410 63367729
Normal newborn 25.28 15.90 29 40854 8312 63439827
Thyrotoxic crisis 25.26 15.90 12 40871 864 63447275
Hypothermia 25.12 15.90 37 40846 13544 63434595
Abscess neck 25.01 15.90 11 40872 662 63447477
Intensive care unit delirium 24.72 15.90 6 40877 50 63448089
Hypovolaemic shock 24.72 15.90 25 40858 6216 63441923
Tracheal injury 24.62 15.90 6 40877 51 63448088
Upper respiratory tract infection 24.59 15.90 11 40872 82036 63366103
Cough 24.58 15.90 101 40782 292642 63155497
COVID-19 24.53 15.90 22 40861 113081 63335058
Congestive hepatopathy 24.42 15.90 18 40865 2924 63445215
Bezold-Jarisch reflex 24.35 15.90 5 40878 17 63448122
Anaesthetic complication cardiac 24.35 15.90 5 40878 17 63448122
Acidosis 24.33 15.90 33 40850 11200 63436939
Endotracheal intubation 24.15 15.90 17 40866 2571 63445568
Urticaria 24.09 15.90 186 40697 165616 63282523
Dry skin 23.79 15.90 4 40879 56883 63391256
Treatment failure 23.46 15.90 59 40824 198984 63249155
Infantile apnoea 23.38 15.90 12 40871 1021 63447118
Hypersensitivity 23.33 15.90 103 40780 292582 63155557
Extubation 23.14 15.90 5 40878 23 63448116
Hyperthermia 23.10 15.90 29 40854 9127 63439012
Eyelid function disorder 23.04 15.90 8 40875 254 63447885
Therapeutic product effect incomplete 22.98 15.90 28 40855 125028 63323111
Air embolism 22.95 15.90 8 40875 257 63447882
Extrasystoles 22.91 15.90 22 40861 5138 63443001
Neck pain 22.90 15.90 8 40875 69310 63378829
CSWS syndrome 22.80 15.90 5 40878 25 63448114
Suspected product contamination 22.80 15.90 5 40878 25 63448114
Balance disorder 22.78 15.90 13 40870 84409 63363730
Hyperammonaemic encephalopathy 22.74 15.90 16 40867 2418 63445721
Mean arterial pressure decreased 22.30 15.90 7 40876 161 63447978
Ventricular arrhythmia 22.27 15.90 19 40864 3809 63444330
Euthyroid sick syndrome 22.24 15.90 6 40877 79 63448060
Encephalitis 22.20 15.90 28 40855 8852 63439287
Apnoeic attack 22.06 15.90 8 40875 289 63447850
Blister 21.88 15.90 31 40852 129783 63318356
Bronchostenosis 21.69 15.90 9 40874 469 63447670
Accidental overdose 21.67 15.90 47 40836 23262 63424877
Foetal exposure during pregnancy 21.66 15.90 57 40826 31905 63416234
Illness 21.54 15.90 3 40880 49056 63399083
Acquired macroglossia 21.52 15.90 7 40876 181 63447958
Sepsis syndrome 21.48 15.90 11 40872 931 63447208
Chronic obstructive pulmonary disease 21.12 15.90 7 40876 62679 63385460
Diabetes mellitus 21.09 15.90 5 40878 55805 63392334
Haemoperitoneum 21.04 15.90 16 40867 2725 63445414
Vision blurred 21.01 15.90 17 40866 91907 63356232
Uterine atony 20.96 15.90 7 40876 197 63447942
Post procedural fever 20.96 15.90 8 40875 334 63447805
Pulmonary alveolar haemorrhage 20.91 15.90 20 40863 4648 63443491
Tidal volume decreased 20.89 15.90 5 40878 39 63448100
Hepatitis C 20.66 15.90 21 40862 5253 63442886
Cystitis 20.63 15.90 5 40878 54986 63393153
Long QT syndrome 20.57 15.90 17 40866 3262 63444877
Atrioventricular block 20.55 15.90 25 40858 7622 63440517
Abdominal rigidity 20.54 15.90 14 40869 2010 63446129
Cholestasis 20.47 15.90 53 40830 29381 63418758
Mucosal inflammation 20.30 15.90 3 40880 46925 63401214
Epilepsy 20.14 15.90 50 40833 27015 63421124
Anuria 20.12 15.90 32 40851 12519 63435620
Extrapyramidal disorder 20.12 15.90 33 40850 13251 63434888
Osteoporosis 20.03 15.90 6 40877 57332 63390807
Emotional distress 20.01 15.90 56 40827 32493 63415646
Idiosyncratic drug reaction 19.85 15.90 10 40873 818 63447321
Syncope 19.81 15.90 28 40855 117357 63330782
Condition aggravated 19.71 15.90 165 40718 402052 63046087
Tonic clonic movements 19.69 15.90 12 40871 1423 63446716
Laryngeal obstruction 19.67 15.90 6 40877 125 63448014
Cardiac massage 19.62 15.90 4 40879 13 63448126
Gait inability 19.51 15.90 5 40878 52954 63395185
Resuscitation 19.48 15.90 11 40872 1133 63447006
Tongue oedema 19.33 15.90 19 40864 4567 63443572
Eosinophilic pneumonia acute 19.26 15.90 8 40875 418 63447721
Night sweats 19.20 15.90 4 40879 48810 63399329
Hepatic function abnormal 19.12 15.90 60 40823 37082 63411057
Ammonia increased 19.08 15.90 19 40864 4637 63443502
Inflammation 19.07 15.90 15 40868 82258 63365881
Bispectral index decreased 19.05 15.90 3 40880 0 63448139
Transcranial electrical motor evoked potential monitoring abnormal 19.05 15.90 3 40880 0 63448139
Hypernatraemia 19.04 15.90 24 40859 7585 63440554
Haemodialysis 18.95 15.90 26 40857 8921 63439218
Grimacing 18.94 15.90 8 40875 436 63447703
Adverse event 18.82 15.90 10 40873 67549 63380590
Renal tubular necrosis 18.66 15.90 30 40853 11848 63436291
Bone pain 18.58 15.90 6 40877 54635 63393504
Foetal heart rate decreased 18.53 15.90 6 40877 153 63447986
Systolic dysfunction 18.50 15.90 12 40871 1587 63446552
Burning sensation 18.46 15.90 6 40877 54401 63393738
Polyuria 18.36 15.90 25 40858 8517 63439622
Tracheal haemorrhage 18.27 15.90 6 40877 160 63447979
Extensor plantar response 18.09 15.90 11 40872 1300 63446839
Abdominal sepsis 18.02 15.90 11 40872 1308 63446831
Haematochezia 18.00 15.90 6 40877 53538 63394601
Lymphangiectasia 17.99 15.90 5 40878 74 63448065
Myocardial depression 17.96 15.90 8 40875 496 63447643
Palpitations 17.96 15.90 28 40855 112742 63335397
Lip oedema 17.94 15.90 17 40866 3907 63444232
General physical health deterioration 17.83 15.90 68 40815 201334 63246805
Nystagmus 17.80 15.90 21 40862 6199 63441940
Pancreatitis necrotising 17.75 15.90 12 40871 1700 63446439
Blood magnesium decreased 17.62 15.90 31 40852 13167 63434972
Hyperdynamic left ventricle 17.60 15.90 6 40877 180 63447959
Respiratory rate decreased 17.48 15.90 16 40867 3519 63444620
Agitation postoperative 17.22 15.90 4 40879 27 63448112
Cardiotoxicity 17.09 15.90 24 40859 8414 63439725
Nerve stimulation test abnormal 16.97 15.90 3 40880 3 63448136
Adverse drug reaction 16.70 15.90 16 40867 79698 63368441
Cardiac dysfunction 16.65 15.90 13 40870 2302 63445837
Peripheral nerve palsy 16.63 15.90 4 40879 32 63448107
Long QT syndrome congenital 16.59 15.90 5 40878 100 63448039
Visual impairment 16.49 15.90 18 40865 84428 63363711
Vertigo 16.48 15.90 9 40874 59878 63388261
Coronary artery bypass 16.38 15.90 13 40870 2356 63445783
Fluid retention 16.38 15.90 9 40874 59677 63388462
Suicidal ideation 16.30 15.90 10 40873 62411 63385728
Chemical peritonitis 16.27 15.90 5 40878 107 63448032
Ventricular asystole 16.27 15.90 5 40878 107 63448032
Pulmonary fibrosis 16.21 15.90 3 40880 39806 63408333
Fat embolism 16.18 15.90 6 40877 231 63447908
Hypertrophic cardiomyopathy 16.16 15.90 11 40872 1576 63446563
Neisseria infection 16.09 15.90 5 40878 111 63448028
Skin ulcer 15.98 15.90 4 40879 43041 63405098

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 1921.37 15.95 708 38455 15233 34902535
Propofol infusion syndrome 1327.90 15.95 289 38874 677 34917091
Anaphylactic reaction 851.90 15.95 500 38663 31801 34885967
Hyperthermia malignant 684.29 15.95 200 38963 1977 34915791
Hypotension 598.49 15.95 964 38199 220685 34697083
Cardiac arrest 597.44 15.95 632 38531 95527 34822241
Bronchospasm 491.22 15.95 240 38923 10491 34907277
Bradycardia 484.65 15.95 505 38658 74913 34842855
Rhabdomyolysis 348.44 15.95 405 38758 67758 34850010
Delayed recovery from anaesthesia 344.26 15.95 94 39069 707 34917061
Fatigue 272.01 15.95 45 39118 370608 34547160
Serotonin syndrome 267.81 15.95 203 38960 19730 34898038
Tachycardia 244.31 15.95 381 38782 84391 34833377
Circulatory collapse 238.88 15.95 194 38969 20844 34896924
Anaesthetic complication 216.85 15.95 71 39092 1049 34916719
Metabolic acidosis 215.42 15.95 255 38908 43425 34874343
Respiratory depression 189.05 15.95 152 39011 16093 34901675
Electrocardiogram ST segment elevation 172.70 15.95 94 39069 5144 34912624
Pulseless electrical activity 169.93 15.95 104 39059 7107 34910661
Haemodynamic instability 169.23 15.95 115 39048 9408 34908360
Diarrhoea 167.01 15.95 117 39046 389795 34527973
Diabetes insipidus 166.20 15.95 76 39087 2852 34914916
Neuromuscular block prolonged 166.13 15.95 48 39115 453 34917315
Ventricular fibrillation 149.36 15.95 155 39008 22799 34894969
Status epilepticus 142.46 15.95 116 39047 12498 34905270
Shock 137.45 15.95 152 39011 24027 34893741
Arthralgia 135.26 15.95 16 39147 170025 34747743
Oxygen saturation decreased 133.26 15.95 226 38937 53592 34864176
Myoclonus 128.83 15.95 117 39046 14608 34903160
Blood pressure decreased 128.44 15.95 217 38946 51298 34866470
Drug reaction with eosinophilia and systemic symptoms 128.05 15.95 171 38992 32841 34884927
Death 127.17 15.95 156 39007 397893 34519875
Hypoxia 117.85 15.95 217 38946 54878 34862890
Airway complication of anaesthesia 114.15 15.95 28 39135 129 34917639
Intensive care unit acquired weakness 113.87 15.95 43 39120 984 34916784
Decreased appetite 113.55 15.95 24 39139 166368 34751400
Hypertriglyceridaemia 113.32 15.95 86 39077 8362 34909406
Fall 113.14 15.95 43 39120 202842 34714926
Drug interaction 109.13 15.95 521 38642 225425 34692343
Toxic epidermal necrolysis 107.67 15.95 127 39036 21519 34896249
Injury 107.27 15.95 124 39039 20563 34897205
Trigemino-cardiac reflex 103.56 15.95 27 39136 166 34917602
Product dose omission issue 101.00 15.95 9 39154 119702 34798066
Multiple organ dysfunction syndrome 100.34 15.95 247 38916 76319 34841449
Dizziness 99.48 15.95 61 39102 218460 34699308
Respiratory acidosis 99.39 15.95 65 39098 4985 34912783
Hypoxic-ischaemic encephalopathy 98.27 15.95 62 39101 4470 34913298
Procedural complication 96.40 15.95 60 39103 4223 34913545
Blood creatine phosphokinase increased 96.31 15.95 177 38986 44680 34873088
Post procedural complication 92.85 15.95 87 39076 11301 34906467
Ventricular tachycardia 91.50 15.95 130 39033 26449 34891319
Negative pressure pulmonary oedema 89.32 15.95 25 39138 208 34917560
Anaesthetic complication neurological 88.52 15.95 27 39136 312 34917456
Tachypnoea 88.50 15.95 106 39057 18246 34899522
Laryngospasm 87.96 15.95 40 39123 1481 34916287
Nausea 87.14 15.95 155 39008 339753 34578015
Intestinal ischaemia 86.58 15.95 71 39092 7723 34910045
Procedural hypotension 85.35 15.95 34 39129 902 34916866
Stress cardiomyopathy 85.12 15.95 43 39120 2016 34915752
Asthenia 84.75 15.95 90 39073 245161 34672607
Headache 84.56 15.95 61 39102 200574 34717194
Pain in extremity 82.76 15.95 20 39143 126493 34791275
Anaphylactoid shock 80.82 15.95 26 39137 362 34917406
Acute respiratory distress syndrome 79.24 15.95 120 39043 25849 34891919
Respiratory arrest 76.40 15.95 123 39040 27920 34889848
Spinal muscular atrophy 76.24 15.95 25 39138 371 34917397
Abdominal pain 73.95 15.95 46 39117 163572 34754196
Weight decreased 73.75 15.95 54 39109 176247 34741521
Pulse absent 73.28 15.95 57 39106 5746 34912022
Fear 72.21 15.95 73 39090 10403 34907365
Kounis syndrome 71.58 15.95 41 39122 2477 34915291
Apnoea 70.47 15.95 59 39104 6605 34911163
Hypercapnia 69.97 15.95 49 39114 4206 34913562
Ventricular arrhythmia 69.16 15.95 54 39109 5474 34912294
Agitation 67.70 15.95 178 38985 57221 34860547
Hypoventilation 67.32 15.95 44 39119 3370 34914398
Cardio-respiratory arrest 66.82 15.95 173 38990 55100 34862668
Peripheral swelling 66.62 15.95 5 39158 76536 34841232
Autonomic nervous system imbalance 65.80 15.95 39 39124 2512 34915256
Constipation 65.44 15.95 36 39127 136946 34780822
Arteriospasm coronary 65.26 15.95 43 39120 3339 34914429
Anaemia 64.69 15.95 101 39062 233234 34684534
Type I hypersensitivity 64.39 15.95 31 39132 1308 34916460
Brain injury 64.16 15.95 54 39109 6088 34911680
Febrile neutropenia 63.89 15.95 37 39126 136812 34780956
Seizure like phenomena 63.62 15.95 26 39137 738 34917030
Neuropathy peripheral 63.33 15.95 9 39154 83254 34834514
Dyspnoea 63.30 15.95 214 38949 376568 34541200
Vasoplegia syndrome 63.10 15.95 34 39129 1822 34915946
Nasopharyngitis 62.56 15.95 4 39159 69964 34847804
Transmission of an infectious agent via product 62.28 15.95 18 39145 170 34917598
Malaise 62.13 15.95 70 39093 185755 34732013
Renal injury 61.23 15.95 69 39094 11126 34906642
Weight increased 60.25 15.95 15 39148 93018 34824750
Blood lactic acid increased 59.90 15.95 54 39109 6674 34911094
Resuscitation 59.06 15.95 30 39133 1423 34916345
Disease progression 58.36 15.95 24 39139 108053 34809715
Drug level changed 58.27 15.95 20 39143 344 34917424
Tryptase increased 58.17 15.95 18 39145 219 34917549
Malignant neoplasm progression 57.40 15.95 14 39149 88032 34829736
Brain oedema 57.28 15.95 74 39089 13747 34904021
Erythema 56.71 15.95 223 38940 88557 34829211
Post procedural fever 56.15 15.95 16 39147 143 34917625
Cyanosis 55.52 15.95 70 39093 12694 34905074
Oedema peripheral 55.06 15.95 33 39130 119779 34797989
Allergy test negative 54.55 15.95 15 39148 116 34917652
Muscle rigidity 54.43 15.95 63 39100 10455 34907313
Anhedonia 54.38 15.95 54 39109 7531 34910237
Sinus arrest 53.97 15.95 30 39133 1710 34916058
Back pain 53.96 15.95 35 39128 121754 34796014
Pneumococcal sepsis 53.70 15.95 26 39137 1111 34916657
Torsade de pointes 52.94 15.95 52 39111 7157 34910611
Respiratory failure 52.68 15.95 251 38912 108321 34809447
Acidosis 52.40 15.95 63 39100 10882 34906886
Endotracheal intubation 52.04 15.95 36 39127 3029 34914739
Neuromuscular blockade 51.92 15.95 17 39146 251 34917517
Cough 51.89 15.95 55 39108 150085 34767683
Hospitalisation 51.63 15.95 3 39160 56899 34860869
Neonatal respiratory depression 51.52 15.95 19 39144 406 34917362
Necrosis ischaemic 50.49 15.95 17 39146 275 34917493
Feeling abnormal 50.09 15.95 6 39157 63229 34854539
Endotracheal intubation complication 49.42 15.95 18 39145 371 34917397
Brugada syndrome 49.29 15.95 22 39141 779 34916989
Dyskinesia 48.78 15.95 89 39074 22324 34895444
Insomnia 48.61 15.95 28 39135 103879 34813889
Multiple-drug resistance 48.52 15.95 43 39120 5196 34912572
Neutropenia 48.21 15.95 63 39100 156715 34761053
Product contamination 48.20 15.95 21 39142 701 34917067
Dystonia 48.00 15.95 60 39103 10785 34906983
Motor neurone disease 47.90 15.95 19 39144 498 34917270
Pulmonary alveolar haemorrhage 47.53 15.95 50 39113 7462 34910306
Stoma closure 47.28 15.95 16 39147 263 34917505
White blood cell count decreased 47.16 15.95 24 39139 95421 34822347
Electrocardiogram QRS complex prolonged 46.99 15.95 41 39122 4853 34912915
Increased bronchial secretion 46.55 15.95 28 39135 1853 34915915
Blood pressure measurement 45.57 15.95 14 39149 166 34917602
Oxygen saturation immeasurable 45.17 15.95 10 39153 26 34917742
Urinary tract infection 43.28 15.95 20 39143 84061 34833707
Hyperammonaemia 43.21 15.95 44 39119 6323 34911445
Hepatorenal failure 42.86 15.95 18 39145 548 34917220
Ischaemic cerebral infarction 42.83 15.95 23 39140 1224 34916544
Mixed liver injury 42.44 15.95 31 39132 2842 34914926
Inappropriate schedule of product administration 42.40 15.95 9 39154 62287 34855481
Electrocardiogram QT prolonged 42.29 15.95 121 39042 40831 34876937
Lower respiratory tract infection bacterial 41.55 15.95 17 39146 484 34917284
Drug ineffective 41.33 15.95 729 38434 456022 34461746
Anaphylactoid reaction 41.11 15.95 28 39135 2297 34915471
Pneumonia 40.82 15.95 239 38924 362388 34555380
Sputum increased 40.62 15.95 28 39135 2342 34915426
Anaesthetic complication cardiac 40.49 15.95 9 39154 24 34917744
Postoperative delirium 40.34 15.95 13 39150 182 34917586
Procedural haemorrhage 39.71 15.95 28 39135 2429 34915339
Metabolic disorder 39.36 15.95 35 39128 4248 34913520
Lymphadenectomy 38.59 15.95 15 39148 372 34917396
Recurrence of neuromuscular blockade 38.51 15.95 13 39150 212 34917556
Paraesthesia 38.46 15.95 12 39151 64160 34853608
Burkholderia test positive 38.34 15.95 20 39143 1003 34916765
Cardiac failure congestive 38.15 15.95 23 39140 83247 34834521
Respiratory tract infection bacterial 37.68 15.95 24 39139 1758 34916010
Rash maculo-papular 37.44 15.95 92 39071 28359 34889409
Coma blister 37.24 15.95 10 39153 70 34917698
Disease complication 37.01 15.95 28 39135 2708 34915060
Emotional distress 37.01 15.95 63 39100 14963 34902805
Chest pain 36.88 15.95 53 39110 126709 34791059
Urticaria 36.87 15.95 153 39010 62224 34855544
Airway peak pressure increased 36.65 15.95 8 39155 19 34917749
Dehydration 36.20 15.95 56 39107 129913 34787855
Hypotonic-hyporesponsive episode 36.08 15.95 8 39155 21 34917747
Opisthotonus 35.86 15.95 15 39148 452 34917316
Sinus tachycardia 35.35 15.95 67 39096 17293 34900475
Post procedural haemorrhage 35.32 15.95 45 39118 8244 34909524
Pancytopenia 34.98 15.95 33 39130 95124 34822644
Heparin-induced thrombocytopenia 34.97 15.95 37 39126 5558 34912210
Priapism 34.78 15.95 35 39128 4959 34912809
Superinfection 34.57 15.95 26 39137 2493 34915275
Delirium 34.37 15.95 118 39045 43873 34873895
Mean arterial pressure decreased 34.33 15.95 11 39152 151 34917617
Drug intolerance 34.19 15.95 12 39151 59558 34858210
Haemodialysis 34.04 15.95 50 39113 10476 34907292
Oculocardiac reflex 33.64 15.95 9 39154 62 34917706
Cellulitis 33.38 15.95 9 39154 52942 34864826
Post procedural hypotension 33.15 15.95 9 39154 66 34917702
Mechanical ventilation 33.12 15.95 23 39140 1947 34915821
Intestinal pseudo-obstruction 33.09 15.95 22 39141 1734 34916034
Therapeutic product effect prolonged 32.87 15.95 12 39151 249 34917519
Atrioventricular block complete 32.67 15.95 46 39117 9273 34908495
Drug ineffective for unapproved indication 32.61 15.95 78 39085 23637 34894131
Muscle spasms 32.59 15.95 22 39141 74979 34842789
Suspected product contamination 32.58 15.95 9 39154 71 34917697
Pulmonary oedema 32.45 15.95 122 39041 47407 34870361
Bronchial disorder 32.45 15.95 20 39143 1383 34916385
Lactic acidosis 32.34 15.95 99 39064 34673 34883095
Hepatitis fulminant 32.22 15.95 31 39132 4159 34913609
Influenza 32.16 15.95 8 39155 49658 34868110
Vomiting 31.80 15.95 156 39007 247465 34670303
Anticholinergic syndrome 31.69 15.95 19 39144 1250 34916518
Suicidal ideation 31.57 15.95 4 39159 40384 34877384
Neuroleptic malignant syndrome 31.43 15.95 65 39098 17869 34899899
General physical health deterioration 31.39 15.95 60 39103 128209 34789559
Cerebral ischaemia 31.27 15.95 37 39126 6285 34911483
Spinal cord infarction 31.13 15.95 12 39151 291 34917477
Hypotonia 30.91 15.95 41 39122 7812 34909956
Plasma cell myeloma 30.90 15.95 5 39158 42032 34875736
Product contamination microbial 30.89 15.95 15 39148 645 34917123
Depression 30.88 15.95 38 39125 97060 34820708
Partial seizures 30.68 15.95 32 39131 4728 34913040
Mucosal ulceration 30.44 15.95 17 39146 978 34916790
Areflexia 30.33 15.95 26 39137 3005 34914763
Intracranial pressure increased 29.92 15.95 29 39134 3926 34913842
Syncope 29.92 15.95 35 39128 91416 34826352
Abdominal pain upper 29.71 15.95 22 39141 71468 34846300
Balance disorder 29.52 15.95 5 39158 40649 34877119
Generalised tonic-clonic seizure 29.50 15.95 70 39093 21104 34896664
Diabetes mellitus 29.49 15.95 8 39155 46865 34870903
Nodal rhythm 29.44 15.95 19 39144 1424 34916344
Stomatitis 29.22 15.95 6 39157 42508 34875260
Symmetrical drug-related intertriginous and flexural exanthema 29.22 15.95 12 39151 345 34917423
Unresponsive to stimuli 28.99 15.95 82 39081 27487 34890281
Electrocardiogram ST-T segment elevation 28.98 15.95 5 39158 0 34917768
Hyporesponsive to stimuli 28.73 15.95 17 39146 1091 34916677
Locked-in syndrome 28.64 15.95 11 39152 264 34917504
Eosinophilia 28.56 15.95 79 39084 26143 34891625
Prostate cancer 28.52 15.95 5 39158 39644 34878124
PCO2 increased 28.41 15.95 14 39149 622 34917146
Acute pulmonary oedema 28.39 15.95 38 39125 7305 34910463
Drug withdrawal syndrome 28.10 15.95 66 39097 19768 34898000
Dyspnoea exertional 27.96 15.95 7 39156 43272 34874496
Sodium retention 27.64 15.95 8 39155 76 34917692
Chest X-ray abnormal 27.34 15.95 29 39134 4369 34913399
End-tidal CO2 increased 27.27 15.95 6 39157 15 34917753
Coagulopathy 27.11 15.95 65 39098 19724 34898044
Chromaturia 27.08 15.95 54 39109 14466 34903302
Hyperkalaemia 27.06 15.95 151 39012 69238 34848530
Bronchitis 26.70 15.95 7 39156 41956 34875812
Hypothermia 26.38 15.95 45 39118 10703 34907065
Systemic inflammatory response syndrome 26.37 15.95 35 39128 6674 34911094
Gait disturbance 26.36 15.95 34 39129 85106 34832662
Electrocardiogram T wave inversion 26.20 15.95 21 39142 2210 34915558
Coma 26.17 15.95 111 39052 45567 34872201
Renin increased 25.88 15.95 8 39155 97 34917671
Pseudocholinesterase deficiency 25.77 15.95 6 39157 21 34917747
Contusion 25.27 15.95 5 39158 36359 34881409
Disseminated intravascular coagulation 25.03 15.95 67 39096 21749 34896019
Haemoglobin decreased 24.99 15.95 62 39101 120710 34797058
Dry skin 24.69 15.95 3 39160 31284 34886484
Neonatal hypoxia 24.47 15.95 11 39152 396 34917372
Clonus 24.33 15.95 22 39141 2728 34915040
Loss of personal independence in daily activities 24.27 15.95 4 39159 33175 34884593
Pruritus 24.16 15.95 80 39083 141901 34775867
Coronary artery disease 24.07 15.95 12 39151 48293 34869475
Scoliosis 24.04 15.95 22 39141 2771 34914997
Local anaesthetic systemic toxicity 23.95 15.95 10 39153 300 34917468
Sinus bradycardia 23.92 15.95 48 39115 12915 34904853
Hepatic cytolysis 23.62 15.95 51 39112 14445 34903323
Hyponatraemia 23.62 15.95 35 39128 82656 34835112
Acidosis hyperchloraemic 23.58 15.95 11 39152 432 34917336
Neutrophil count decreased 23.56 15.95 14 39149 51090 34866678
Blood catecholamines increased 23.50 15.95 5 39158 10 34917758
Air embolism 23.45 15.95 8 39155 135 34917633
Pain 23.43 15.95 134 39029 204541 34713227
Unwanted awareness during anaesthesia 23.43 15.95 6 39157 34 34917734
Laryngeal oedema 23.36 15.95 24 39139 3484 34914284
Herpes zoster 23.34 15.95 5 39158 34394 34883374
Chronic obstructive pulmonary disease 23.12 15.95 13 39150 48905 34868863
Acute generalised exanthematous pustulosis 23.09 15.95 33 39130 6743 34911025
Pneumomediastinum 23.07 15.95 20 39143 2347 34915421
Musculoskeletal pain 23.05 15.95 4 39159 31959 34885809
Hyperthermia 23.01 15.95 42 39121 10535 34907233
Mydriasis 22.86 15.95 34 39129 7203 34910565
Brain death 22.83 15.95 21 39142 2662 34915106
Ventricular extrasystoles 22.80 15.95 45 39118 11963 34905805
Sleep disorder 22.78 15.95 4 39159 31684 34886084
Supraventricular tachycardia 22.75 15.95 43 39120 11074 34906694
Acute kidney injury 22.73 15.95 473 38690 304515 34613253
Malignant catatonia 22.65 15.95 9 39154 237 34917531
Sinusitis 22.64 15.95 9 39154 41393 34876375
Subcutaneous emphysema 22.60 15.95 15 39148 1179 34916589
Paroxysmal sympathetic hyperactivity 22.60 15.95 6 39157 40 34917728
Periorbital swelling 22.58 15.95 12 39151 625 34917143
Skin test positive 22.51 15.95 10 39153 350 34917418
Conversion disorder 22.46 15.95 10 39153 352 34917416
Post-injection delirium sedation syndrome 22.44 15.95 11 39152 483 34917285
Suspected product quality issue 22.42 15.95 8 39155 155 34917613
Motor dysfunction 22.36 15.95 33 39130 6941 34910827
Nystagmus 22.34 15.95 27 39136 4688 34913080
Electroencephalogram abnormal 22.27 15.95 20 39143 2458 34915310
Trismus 22.16 15.95 20 39143 2475 34915293
Upper airway obstruction 22.10 15.95 12 39151 653 34917115
Epistaxis 21.63 15.95 20 39143 58231 34859537
Depressed level of consciousness 21.44 15.95 100 39063 42741 34875027
Weight bearing difficulty 21.31 15.95 14 39149 1081 34916687
Dry mouth 21.27 15.95 4 39159 30161 34887607
Pupil fixed 21.25 15.95 17 39146 1784 34915984
Infusion related reaction 21.18 15.95 17 39146 53040 34864728
Septic shock 20.90 15.95 145 39018 71689 34846079
Atelectasis 20.90 15.95 55 39108 17672 34900096
Seizure 20.37 15.95 193 38970 104664 34813104
Pulmonary embolism 20.22 15.95 44 39119 89702 34828066
Euthanasia 20.21 15.95 5 39158 24 34917744
Continuous haemodiafiltration 20.09 15.95 13 39150 979 34916789
Dialysis 20.08 15.95 41 39122 11167 34906601
Hyperventilation 20.05 15.95 20 39143 2804 34914964
Hypoglycaemia 20.01 15.95 19 39144 54621 34863147
Neuromyopathy 19.59 15.95 13 39150 1021 34916747
Hypoaesthesia 19.57 15.95 24 39139 61420 34856348
Premature recovery from anaesthesia 19.52 15.95 4 39159 6 34917762
Systolic anterior motion of mitral valve 19.42 15.95 5 39158 29 34917739
Pneumothorax 19.30 15.95 56 39107 19036 34898732
Unevaluable event 19.29 15.95 80 39083 32510 34885258
Product administered to patient of inappropriate age 19.23 15.95 21 39142 3270 34914498
COVID-19 19.20 15.95 36 39127 77514 34840254
Congenital megaureter 18.92 15.95 7 39156 151 34917617
Lung consolidation 18.91 15.95 28 39135 5908 34911860
Capillary nail refill test abnormal 18.87 15.95 5 39158 33 34917735
Chills 18.75 15.95 155 39008 80888 34836880
Cardiogenic shock 18.73 15.95 69 39094 26549 34891219
Electrocardiogram ST segment depression 18.49 15.95 18 39145 2450 34915318
Blood pressure immeasurable 18.45 15.95 12 39151 911 34916857
Urinary bladder rupture 18.36 15.95 6 39157 88 34917680
Long QT syndrome 18.35 15.95 19 39144 2784 34914984
Abdominal compartment syndrome 18.10 15.95 12 39151 941 34916827
Oliguria 17.88 15.95 33 39130 8347 34909421
Demyelination 17.86 15.95 20 39143 3201 34914567
Respiratory alkalosis 17.80 15.95 15 39148 1694 34916074
Infection 17.78 15.95 48 39115 90867 34826901
Fear of death 17.77 15.95 10 39153 584 34917184
Migraine with aura 17.67 15.95 10 39153 590 34917178
Transcranial electrical motor evoked potential monitoring abnormal 17.65 15.95 4 39159 12 34917756
Skin test negative 17.61 15.95 5 39158 44 34917724
Hypernatraemia 17.57 15.95 33 39130 8457 34909311
Pleural effusion 17.54 15.95 41 39122 81505 34836263
Transurethral resection syndrome 17.41 15.95 4 39159 13 34917755
Light anaesthesia 17.39 15.95 3 39160 0 34917768
Therapeutic response prolonged 17.39 15.95 3 39160 0 34917768
Platelet count decreased 17.38 15.95 72 39091 119645 34798123
Prinzmetal angina 17.37 15.95 12 39151 1007 34916761
Haematuria traumatic 17.35 15.95 7 39156 192 34917576
Sedation complication 17.29 15.95 15 39148 1762 34916006
Procedural pain 17.26 15.95 24 39139 4782 34912986
Anaesthetic complication pulmonary 17.18 15.95 4 39159 14 34917754
Myoglobin blood increased 17.16 15.95 19 39144 3004 34914764
Palpitations 17.00 15.95 12 39151 39974 34877794
Eye movement disorder 16.95 15.95 22 39141 4105 34913663
Myocardial infarction 16.86 15.95 74 39089 121011 34796757
Electrocardiogram abnormal 16.77 15.95 34 39129 9213 34908555
Non-cardiogenic pulmonary oedema 16.77 15.95 10 39153 651 34917117
Nephrogenic diabetes insipidus 16.73 15.95 13 39150 1308 34916460
Complication of device removal 16.70 15.95 5 39158 54 34917714
Aspiration 16.64 15.95 40 39123 12154 34905614
Gastrooesophageal reflux disease 16.64 15.95 11 39152 37913 34879855
Atonic urinary bladder 16.38 15.95 4 39159 18 34917750
Respiratory distress 16.22 15.95 81 39082 35584 34882184
Intestinal obstruction 16.15 15.95 3 39160 22819 34894949
Hepatocellular injury 15.98 15.95 58 39105 22153 34895615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 4489.03 14.06 1566 73384 34430 79635008
Anaphylactic reaction 1955.99 14.06 1126 73824 82617 79586821
Propofol infusion syndrome 1907.35 14.06 429 74521 1554 79667884
Hypotension 1435.41 14.06 1907 73043 438410 79231028
Cardiac arrest 1337.64 14.06 1182 73768 170914 79498524
Bronchospasm 1187.24 14.06 542 74408 24317 79645121
Hyperthermia malignant 949.56 14.06 265 74685 2652 79666786
Bradycardia 815.03 14.06 808 74142 134749 79534689
Delayed recovery from anaesthesia 670.31 14.06 179 74771 1494 79667944
Serotonin syndrome 664.35 14.06 453 74497 44574 79624864
Tachycardia 610.12 14.06 792 74158 176976 79492462
Circulatory collapse 591.62 14.06 394 74556 37274 79632164
Rhabdomyolysis 559.73 14.06 582 74368 102549 79566889
Fatigue 529.49 14.06 115 74835 929612 78739826
Stress cardiomyopathy 418.01 14.06 206 74744 10960 79658478
Arthralgia 392.58 14.06 41 74909 571762 79097676
Neuromuscular block prolonged 378.76 14.06 103 74847 927 79668511
Metabolic acidosis 372.87 14.06 423 74527 82106 79587332
Haemodynamic instability 368.66 14.06 220 74730 17162 79652276
Status epilepticus 366.98 14.06 251 74699 24790 79644648
Diarrhoea 366.67 14.06 186 74764 880303 78789135
Ventricular fibrillation 355.79 14.06 271 74679 31655 79637783
Pulseless electrical activity 347.41 14.06 197 74753 13963 79655475
Drug interaction 342.35 14.06 1009 73941 414174 79255264
Anaesthetic complication 338.66 14.06 120 74830 2739 79666699
Shock 311.35 14.06 286 74664 43262 79626176
Diabetes insipidus 310.48 14.06 133 74817 5104 79664334
Ventricular tachycardia 306.83 14.06 279 74671 41656 79627782
Electrocardiogram ST segment elevation 299.74 14.06 150 74800 8247 79661191
Multiple organ dysfunction syndrome 298.11 14.06 459 74491 119787 79549651
Blood pressure decreased 297.72 14.06 415 74535 99051 79570387
Respiratory depression 291.39 14.06 227 74723 27403 79642035
Oxygen saturation decreased 280.63 14.06 464 74486 128583 79540855
Myoclonus 278.23 14.06 221 74729 27439 79641999
Fall 269.36 14.06 64 74886 487565 79181873
Procedural hypotension 251.41 14.06 88 74862 1935 79667503
Blood creatine phosphokinase increased 249.26 14.06 309 74641 65781 79603657
Hypoxia 248.73 14.06 389 74561 102854 79566584
Joint swelling 246.80 14.06 5 74945 288641 79380797
Headache 237.87 14.06 162 74788 653610 79015828
Airway complication of anaesthesia 231.83 14.06 58 74892 362 79669076
Apnoea 217.11 14.06 136 74814 11568 79657870
Respiratory acidosis 214.97 14.06 133 74817 11067 79658371
Dizziness 205.74 14.06 120 74830 526321 79143117
Pain in extremity 195.05 14.06 51 74899 364487 79304951
Nausea 194.84 14.06 379 74571 956817 78712621
Type I hypersensitivity 194.53 14.06 91 74859 4307 79665131
Anaphylactoid shock 191.83 14.06 57 74893 724 79668714
Drug intolerance 191.51 14.06 15 74935 264104 79405334
Nasopharyngitis 191.08 14.06 12 74938 253869 79415569
Post procedural complication 191.06 14.06 167 74783 23662 79645776
Procedural complication 187.59 14.06 108 74842 7875 79661563
Malaise 186.69 14.06 115 74835 489754 79179684
Intestinal ischaemia 184.95 14.06 129 74821 13141 79656297
Alopecia 183.32 14.06 8 74942 231347 79438091
Myoglobin urine present 181.00 14.06 57 74893 890 79668548
Peripheral swelling 178.00 14.06 22 74928 269595 79399843
Laryngospasm 177.71 14.06 83 74867 3914 79665524
Decreased appetite 177.37 14.06 51 74899 342367 79327071
Dystonia 175.66 14.06 152 74798 21247 79648191
Weight increased 172.85 14.06 27 74923 277359 79392079
Abdominal discomfort 171.67 14.06 18 74932 250709 79418729
Drug reaction with eosinophilia and systemic symptoms 171.54 14.06 254 74696 63990 79605448
Kounis syndrome 169.24 14.06 82 74868 4200 79665238
Cardio-respiratory arrest 166.96 14.06 336 74614 108174 79561264
Product dose omission issue 166.36 14.06 19 74931 247518 79421920
Rheumatoid arthritis 162.59 14.06 8 74942 208462 79460976
Hypertriglyceridaemia 161.74 14.06 117 74833 12623 79656815
Anaesthetic complication neurological 158.17 14.06 47 74903 597 79668841
Torsade de pointes 156.14 14.06 136 74814 19176 79650262
Pain 156.05 14.06 264 74686 703538 78965900
Tryptase increased 153.20 14.06 46 74904 607 79668831
Arteriospasm coronary 152.87 14.06 89 74861 6627 79662811
Hypoventilation 152.02 14.06 91 74859 7133 79662305
Dyspnoea 146.59 14.06 373 74577 856652 78812786
Unwanted awareness during anaesthesia 145.49 14.06 38 74912 288 79669150
Intensive care unit acquired weakness 144.71 14.06 58 74892 1875 79667563
Trigemino-cardiac reflex 142.77 14.06 36 74914 233 79669205
Weight decreased 141.42 14.06 79 74871 355119 79314319
Arthropathy 140.70 14.06 6 74944 177105 79492333
Anaphylactoid reaction 139.94 14.06 78 74872 5344 79664094
Allergy test negative 139.80 14.06 37 74913 297 79669141
Sinusitis 136.51 14.06 13 74937 195488 79473950
Multiple-drug resistance 135.47 14.06 91 74859 8717 79660721
Generalised tonic-clonic seizure 133.95 14.06 185 74765 43725 79625713
Respiratory arrest 130.47 14.06 211 74739 57339 79612099
Acute respiratory distress syndrome 130.45 14.06 183 74767 43884 79625554
Agitation 130.42 14.06 289 74661 99426 79570012
Toxic epidermal necrolysis 128.81 14.06 183 74767 44398 79625040
Respiratory failure 128.43 14.06 418 74532 180493 79488945
Anticholinergic syndrome 127.38 14.06 64 74886 3547 79665891
Unresponsive to stimuli 125.74 14.06 204 74746 55584 79613854
Asthenia 125.63 14.06 179 74771 511510 79157928
Brain oedema 119.99 14.06 133 74817 25130 79644308
Infusion related reaction 119.69 14.06 34 74916 230203 79439235
Constipation 118.46 14.06 59 74891 282991 79386447
Vasoplegia syndrome 118.34 14.06 61 74889 3569 79665869
Hypoxic-ischaemic encephalopathy 115.99 14.06 79 74871 7741 79661697
Electrocardiogram QT prolonged 114.87 14.06 259 74691 90127 79579311
Clonus 113.26 14.06 74 74876 6766 79662672
Tachypnoea 113.02 14.06 145 74805 31918 79637520
Opisthotonus 112.97 14.06 37 74913 659 79668779
Hypercapnia 111.02 14.06 81 74869 8854 79660584
Labile blood pressure 110.22 14.06 50 74900 2203 79667235
Contusion 109.06 14.06 8 74942 148768 79520670
Abdominal pain 108.28 14.06 124 74826 389445 79279993
Erythema 108.14 14.06 456 74494 222834 79446604
Insomnia 105.79 14.06 49 74901 245121 79424317
Pruritus 105.01 14.06 130 74820 394518 79274920
Pulse absent 104.31 14.06 82 74868 10021 79659417
Necrosis ischaemic 103.97 14.06 39 74911 1051 79668387
Swelling 103.76 14.06 37 74913 216674 79452764
Blood lactic acid increased 103.53 14.06 90 74860 12654 79656784
PCO2 increased 103.39 14.06 45 74905 1795 79667643
Endotracheal intubation complication 103.08 14.06 36 74914 786 79668652
Fear 101.41 14.06 114 74836 21872 79647566
Seizure 100.42 14.06 397 74553 188437 79481001
Drug ineffective for unapproved indication 100.36 14.06 176 74774 51062 79618376
Systemic lupus erythematosus 100.04 14.06 3 74947 121146 79548292
Negative pressure pulmonary oedema 97.87 14.06 26 74924 212 79669226
Partial seizures 97.32 14.06 75 74875 8903 79660535
Dyskinesia 97.21 14.06 161 74789 44612 79624826
Anaesthetic complication pulmonary 96.84 14.06 21 74929 61 79669377
Stomatitis 96.74 14.06 12 74938 146745 79522693
Muscle rigidity 96.71 14.06 106 74844 19776 79649662
Acute generalised exanthematous pustulosis 96.36 14.06 99 74851 17155 79652283
Mydriasis 96.31 14.06 100 74850 17543 79651895
Renal injury 96.12 14.06 98 74852 16829 79652609
Arthritis 94.30 14.06 3 74947 114877 79554561
Urinary tract infection 93.07 14.06 73 74877 274439 79394999
Sinus tachycardia 92.90 14.06 142 74808 36766 79632672
Pulmonary oedema 92.83 14.06 235 74715 88019 79581419
Cardiogenic shock 91.37 14.06 151 74799 41763 79627675
Electrocardiogram QRS complex prolonged 91.03 14.06 78 74872 10755 79658683
Back pain 90.97 14.06 91 74859 304089 79365349
Mitochondrial DNA mutation 90.89 14.06 28 74922 405 79669033
Neuromuscular blockade 90.79 14.06 30 74920 550 79668888
Disseminated intravascular coagulation 88.95 14.06 137 74813 35705 79633733
Amylase increased 88.72 14.06 78 74872 11131 79658307
Inappropriate schedule of product administration 87.90 14.06 11 74939 133617 79535821
Ventricular arrhythmia 87.52 14.06 70 74880 8770 79660668
Musculoskeletal stiffness 87.03 14.06 28 74922 174980 79494458
Postoperative delirium 87.02 14.06 26 74924 337 79669101
Death 86.58 14.06 260 74690 566254 79103184
Neuropathy peripheral 85.19 14.06 15 74935 141290 79528148
Neutropenia 84.98 14.06 87 74863 287623 79381815
Bronchitis 82.97 14.06 12 74938 130632 79538806
Anaemia 82.71 14.06 185 74765 444830 79224608
Influenza 82.08 14.06 12 74938 129594 79539844
Laryngeal oedema 81.82 14.06 65 74885 8064 79661374
Disease progression 80.83 14.06 36 74914 184326 79485112
Abdominal pain upper 80.41 14.06 56 74894 223763 79445675
Injection site pain 80 14.06 13 74937 129825 79539613
Oedema peripheral 78.30 14.06 73 74877 252215 79417223
Coagulopathy 77.52 14.06 129 74821 35877 79633561
Hepatorenal failure 77.37 14.06 33 74917 1252 79668186
Resuscitation 77.22 14.06 40 74910 2364 79667074
Cough 77.07 14.06 142 74808 366647 79302791
Malignant neoplasm progression 76.60 14.06 17 74933 135973 79533465
Pneumonia 76.52 14.06 340 74610 659906 79009532
Discomfort 76.46 14.06 13 74937 125604 79543834
Atrioventricular block complete 76.39 14.06 86 74864 16524 79652914
Spinal muscular atrophy 75.96 14.06 24 74926 379 79669059
Intra-abdominal pressure increased 75.64 14.06 22 74928 258 79669180
Anhedonia 75.21 14.06 81 74869 14817 79654621
Post procedural haemorrhage 75.20 14.06 78 74872 13666 79655772
Therapeutic product effect prolonged 75.08 14.06 26 74924 553 79668885
Acute pulmonary oedema 74.72 14.06 79 74871 14151 79655287
Encephalopathy 74.58 14.06 183 74767 67214 79602224
Oliguria 74.25 14.06 84 74866 16225 79653213
Chest pain 73.99 14.06 94 74856 282210 79387228
Acidosis 73.81 14.06 92 74858 19670 79649768
Procedural haemorrhage 73.28 14.06 49 74901 4657 79664781
Wound 73.01 14.06 11 74939 116168 79553270
Ventricular extrasystoles 72.43 14.06 91 74859 19613 79649825
Seizure like phenomena 71.52 14.06 35 74915 1832 79667606
Feeling abnormal 71.52 14.06 30 74920 159169 79510269
Psoriasis 71.24 14.06 3 74947 89584 79579854
Cyanosis 70.72 14.06 102 74848 25080 79644358
Pulmonary alveolar haemorrhage 69.96 14.06 69 74881 11388 79658050
Drug ineffective 69.83 14.06 1412 73538 1079501 78589937
Gait disturbance 69.28 14.06 56 74894 207450 79461988
Electroencephalogram abnormal 69.19 14.06 50 74900 5384 79664054
Dyspepsia 68.97 14.06 10 74940 108677 79560761
Loss of personal independence in daily activities 68.55 14.06 8 74942 102572 79566866
Recurrence of neuromuscular blockade 68.53 14.06 21 74929 298 79669140
Neuroleptic malignant syndrome 67.91 14.06 105 74845 27454 79641984
Lower respiratory tract infection 67.28 14.06 19 74931 129201 79540237
Febrile neutropenia 66.90 14.06 71 74879 230928 79438510
Ischaemic cerebral infarction 66.87 14.06 37 74913 2498 79666940
Delirium 66.84 14.06 203 74747 84424 79585014
Stridor 66.76 14.06 49 74901 5404 79664034
White blood cell count decreased 66.45 14.06 48 74902 188240 79481198
Coma 66.41 14.06 227 74723 100422 79569016
Toxic encephalopathy 66.36 14.06 67 74883 11373 79658065
Endotracheal intubation 66.24 14.06 46 74904 4651 79664787
Infection 65.94 14.06 78 74872 241634 79427804
Acidosis hyperchloraemic 65.59 14.06 26 74924 816 79668622
Upper airway obstruction 64.56 14.06 30 74920 1398 79668040
Suspected product quality issue 64.43 14.06 20 74930 297 79669141
Premature delivery 64.36 14.06 94 74856 23373 79646065
Septic shock 64.29 14.06 257 74693 122544 79546894
Contraindicated product administered 64.13 14.06 34 74916 157504 79511934
Rash maculo-papular 63.90 14.06 154 74796 55924 79613514
Local anaesthetic systemic toxicity 63.24 14.06 27 74923 1027 79668411
Dehydration 62.60 14.06 85 74865 248102 79421336
Ventricular hypokinesia 62.53 14.06 59 74891 9220 79660218
Carcinoid crisis 62.12 14.06 22 74928 501 79668937
Post procedural fever 61.92 14.06 22 74928 506 79668932
PO2 increased 61.52 14.06 30 74920 1558 79667880
Herpes zoster 60.39 14.06 8 74942 93075 79576363
Renal failure 59.98 14.06 358 74592 200610 79468828
Gastrointestinal disorder 59.96 14.06 20 74930 122185 79547253
Muscle spasms 59.78 14.06 46 74904 174684 79494754
Anaesthetic complication cardiac 59.25 14.06 14 74936 66 79669372
Brugada syndrome 59.07 14.06 27 74923 1211 79668227
Hospitalisation 59.03 14.06 9 74941 94227 79575211
CSF oligoclonal band present 58.86 14.06 20 74930 401 79669037
Brain injury 58.81 14.06 63 74887 11454 79657984
Airway peak pressure increased 58.62 14.06 19 74931 327 79669111
Troponin increased 58.52 14.06 81 74869 19174 79650264
Renal impairment 58.41 14.06 298 74652 157485 79511953
Renal ischaemia 57.52 14.06 26 74924 1136 79668302
Systemic inflammatory response syndrome 57.28 14.06 62 74888 11403 79658035
Skin test positive 57.26 14.06 26 74924 1148 79668290
Sinus arrest 57.09 14.06 38 74912 3584 79665854
Blood pH decreased 56.93 14.06 42 74908 4669 79664769
Lactic acidosis 56.71 14.06 170 74780 70189 79599249
Injury 56.68 14.06 181 74769 77315 79592123
Acute kidney injury 56.42 14.06 740 74210 518664 79150774
Hepatocellular injury 55.62 14.06 132 74818 47461 79621977
Suspected product contamination 55.60 14.06 14 74936 90 79669348
Mucosal inflammation 55.56 14.06 4 74946 75576 79593862
Product contamination 55.50 14.06 26 74924 1234 79668204
Musculoskeletal pain 55.26 14.06 14 74936 102340 79567098
Mobility decreased 54.90 14.06 23 74927 122152 79547286
General physical health deterioration 54.77 14.06 110 74840 275128 79394310
Haemodialysis 54.57 14.06 76 74874 18092 79651346
Hypoaesthesia 54.33 14.06 53 74897 179299 79490139
Exposure during pregnancy 54.01 14.06 213 74737 100919 79568519
Blood gases abnormal 54.00 14.06 25 74925 1155 79668283
Oculogyric crisis 53.98 14.06 34 74916 2918 79666520
Dry mouth 53.80 14.06 9 74941 88010 79581428
Nasal congestion 53.65 14.06 5 74945 76547 79592891
Hyperkalaemia 53.28 14.06 231 74719 114167 79555271
Hepatic failure 53.27 14.06 152 74798 61060 79608378
Vomiting 53.19 14.06 387 74563 665441 79003997
Drug level changed 52.77 14.06 20 74930 555 79668883
Posterior reversible encephalopathy syndrome 52.40 14.06 91 74859 26190 79643248
Hepatic ischaemia 52.20 14.06 24 74926 1091 79668347
Eosinophilia 52.17 14.06 125 74825 45220 79624218
Hyperammonaemia 51.98 14.06 58 74892 11035 79658403
Urticaria 51.52 14.06 324 74626 184877 79484561
Hepatitis acute 51.21 14.06 68 74882 15474 79653964
Asthma 50.93 14.06 32 74918 135063 79534375
Maternal exposure during delivery 50.86 14.06 25 74925 1321 79668117
End-tidal CO2 decreased 50.71 14.06 11 74939 32 79669406
Hyperreflexia 50.27 14.06 50 74900 8335 79661103
Increased bronchial secretion 50.27 14.06 34 74916 3293 79666145
Syncope 49.91 14.06 57 74893 179392 79490046
Oxygen saturation immeasurable 49.74 14.06 11 74939 36 79669402
Angioedema 49.72 14.06 171 74779 75864 79593574
Supraventricular tachycardia 49.57 14.06 79 74871 21191 79648247
Subcutaneous emphysema 49.57 14.06 27 74923 1767 79667671
Arrhythmia 49.34 14.06 148 74802 61124 79608314
Depression 49.07 14.06 80 74870 216710 79452728
Mean arterial pressure decreased 48.94 14.06 17 74933 365 79669073
Balance disorder 48.81 14.06 16 74934 98841 79570597
Unmasking of previously unidentified disease 48.78 14.06 28 74922 2029 79667409
Sinus bradycardia 48.49 14.06 86 74864 25161 79644277
Stoma closure 48.44 14.06 16 74934 293 79669145
Foetal death 48.29 14.06 48 74902 7996 79661442
Blood pressure immeasurable 48.19 14.06 28 74922 2076 79667362
Motor neurone disease 48.15 14.06 19 74931 589 79668849
Brain death 47.95 14.06 41 74909 5636 79663802
Pneumatosis 47.55 14.06 21 74929 868 79668570
Priapism 47.45 14.06 37 74913 4468 79664970
Impaired healing 47.30 14.06 12 74938 87643 79581795
Myoclonic epilepsy 47.21 14.06 27 74923 1943 79667495
Irritable bowel syndrome 46.61 14.06 3 74947 62238 79607200
Autonomic nervous system imbalance 46.55 14.06 37 74913 4593 79664845
Cardiac output decreased 46.23 14.06 26 74924 1812 79667626
Respiratory distress 46.11 14.06 140 74810 58199 79611239
Acute hepatic failure 45.97 14.06 93 74857 30020 79639418
Depressed level of consciousness 45.64 14.06 196 74754 96456 79572982
COVID-19 45.03 14.06 49 74901 157625 79511813
Emotional distress 44.71 14.06 109 74841 39860 79629578
Gastrooesophageal reflux disease 44.67 14.06 21 74929 104225 79565213
Hepatic cytolysis 44.03 14.06 86 74864 27065 79642373
Diabetes mellitus 43.73 14.06 10 74940 78380 79591058
Injection site erythema 43.58 14.06 10 74940 78187 79591251
Hyperthermia 43.43 14.06 68 74882 17969 79651469
Mental status changes postoperative 43.26 14.06 13 74937 172 79669266
Mixed liver injury 43.25 14.06 44 74906 7534 79661904
Product contamination microbial 43.16 14.06 20 74930 926 79668512
Pneumococcal sepsis 43.13 14.06 24 74926 1638 79667800
Phrenic nerve paralysis 43.01 14.06 15 74935 326 79669112
Paraesthesia 42.84 14.06 62 74888 176261 79493177
Electrocardiogram ST segment depression 42.78 14.06 36 74914 4842 79664596
Air embolism 42.66 14.06 16 74934 431 79669007
Hepatitis 42.43 14.06 132 74818 55595 79613843
Acute postoperative sialadenitis 42.35 14.06 10 74940 47 79669391
Hypotonia 41.93 14.06 56 74894 12814 79656624
Gene mutation 41.90 14.06 28 74922 2658 79666780
Macroglossia 41.86 14.06 21 74929 1160 79668278
Dry skin 41.45 14.06 7 74943 67988 79601450
Cardiac failure congestive 40.95 14.06 44 74906 142358 79527080
Oxygen saturation abnormal 40.56 14.06 34 74916 4548 79664890
Chest discomfort 40.42 14.06 42 74908 138002 79531436
Hypocapnia 40.33 14.06 17 74933 626 79668812
Pseudocholinesterase deficiency 40.27 14.06 12 74938 154 79669284
Left ventricle outflow tract obstruction 40.21 14.06 15 74935 398 79669040
Chronic obstructive pulmonary disease 40.15 14.06 15 74935 85404 79584034
Palpitations 40.00 14.06 36 74914 126574 79542864
Chromaturia 39.88 14.06 80 74870 25666 79643772
Upper respiratory tract infection 39.63 14.06 18 74932 91150 79578288
Procedural hypertension 39.52 14.06 14 74936 319 79669119
Muscle relaxant therapy 39.44 14.06 12 74938 166 79669272
Therapeutic product effect incomplete 39.37 14.06 45 74905 141600 79527838
Skin test negative 39.29 14.06 9 74941 36 79669402
Aspiration 39.15 14.06 69 74881 20089 79649349
Unevaluable event 38.99 14.06 128 74822 55457 79613981
Mechanical ventilation 38.81 14.06 27 74923 2737 79666701
Wrong product administered 38.63 14.06 45 74905 8967 79660471
Migraine 38.46 14.06 17 74933 87476 79581962
Fibromyalgia 38.40 14.06 7 74943 64333 79605105
Respiratory tract infection bacterial 38.18 14.06 24 74926 2053 79667385
Dyspnoea exertional 38.15 14.06 17 74933 87056 79582382
Hypothermia 38.05 14.06 73 74877 22673 79646765
Pneumothorax 38.03 14.06 83 74867 28240 79641198
Nodal rhythm 38.00 14.06 28 74922 3107 79666331
Extravasation 37.77 14.06 30 74920 3720 79665718
Alanine aminotransferase increased 37.75 14.06 272 74678 162298 79507140
Thyrotoxic crisis 37.36 14.06 20 74930 1264 79668174
Confusion postoperative 36.83 14.06 12 74938 210 79669228
Long QT syndrome 36.61 14.06 36 74914 5919 79663519
Suicidal ideation 36.57 14.06 13 74937 76327 79593111
Hepatorenal syndrome 36.53 14.06 31 74919 4218 79665220
Metabolic disorder 36.36 14.06 44 74906 9126 79660312
Inadequate aseptic technique in use of product 36.00 14.06 10 74940 98 79669340
Neck pain 35.86 14.06 13 74937 75404 79594034
Hepatitis fulminant 35.81 14.06 39 74911 7223 79662215
Blood lactate dehydrogenase increased 35.77 14.06 99 74851 39071 79630367
Hypernatraemia 35.52 14.06 55 74895 14396 79655042
Intentional product use issue 35.48 14.06 55 74895 152057 79517381
Blood pressure measurement 35.33 14.06 14 74936 439 79668999
Pleocytosis 35.23 14.06 20 74930 1419 79668019
Oculocardiac reflex 35.21 14.06 9 74941 62 79669376
Post-injection delirium sedation syndrome 35.14 14.06 15 74935 570 79668868
Allergy test positive 35.12 14.06 16 74934 712 79668726
Areflexia 35.04 14.06 34 74916 5500 79663938
Tracheal deviation 35.03 14.06 11 74939 170 79669268
Fluid retention 34.99 14.06 11 74939 69798 79599640
Drug withdrawal syndrome 34.98 14.06 91 74859 34627 79634811
Cardiovascular insufficiency 34.73 14.06 26 74924 2955 79666483
Hyperlactacidaemia 34.73 14.06 34 74916 5561 79663877
Oropharyngeal pain 34.66 14.06 31 74919 109322 79560116
Neoplasm progression 34.60 14.06 4 74946 51678 79617760
Myoglobinuria 34.46 14.06 18 74932 1082 79668356
Spinal cord infarction 34.24 14.06 15 74935 608 79668830
Transcranial electrical motor evoked potential monitoring abnormal 34.12 14.06 7 74943 14 79669424
Atelectasis 34.00 14.06 86 74864 32171 79637267
Tonic clonic movements 33.88 14.06 23 74927 2241 79667197
Ill-defined disorder 33.70 14.06 10 74940 65865 79603573
Nystagmus 33.66 14.06 44 74906 9860 79659578
Plasma cell myeloma 33.55 14.06 5 74945 53254 79616184
Myoglobin blood increased 33.45 14.06 26 74924 3125 79666313
Premature recovery from anaesthesia 33.39 14.06 6 74944 3 79669435
Post procedural hypotension 33.19 14.06 9 74941 80 79669358
Intracranial pressure increased 33.11 14.06 40 74910 8282 79661156
Perforation 32.72 14.06 19 74931 1407 79668031
Sleep disorder 32.69 14.06 20 74930 85657 79583781
Vertigo 32.69 14.06 12 74938 69070 79600368
Ultrasound ovary abnormal 32.42 14.06 9 74941 88 79669350
End-tidal CO2 increased 32.37 14.06 7 74943 20 79669418
Hypovolaemia 32.36 14.06 59 74891 17632 79651806
Pancytopenia 32.30 14.06 67 74883 165678 79503760
Paralysis 32.17 14.06 50 74900 13127 79656311
Symmetrical drug-related intertriginous and flexural exanthema 32.12 14.06 16 74934 870 79668568
Hyponatraemia 32.10 14.06 75 74875 177773 79491665
Motor dysfunction 31.99 14.06 53 74897 14680 79654758
Myotonia 31.85 14.06 11 74939 232 79669206
Depressed mood 31.85 14.06 4 74946 48476 79620962
Systolic anterior motion of mitral valve 31.83 14.06 8 74942 51 79669387
Neutrophil count decreased 31.79 14.06 25 74925 93934 79575504
Face oedema 31.76 14.06 77 74873 28059 79641379
Atrioventricular dissociation 31.63 14.06 12 74938 334 79669104
Haematochezia 31.36 14.06 22 74928 87623 79581815
Cholestasis 31.32 14.06 114 74836 51995 79617443
Bone pain 31.32 14.06 7 74943 55735 79613703
Lower respiratory tract infection bacterial 30.97 14.06 16 74934 940 79668498
Cystitis 30.91 14.06 6 74944 52726 79616712
C-reactive protein increased 30.72 14.06 46 74904 128981 79540457
Disease complication 30.64 14.06 30 74920 4907 79664531
Pancreatitis necrotising 30.54 14.06 27 74923 3881 79665557
Atrioventricular block second degree 30.49 14.06 36 74914 7276 79662162
Irregular breathing 30.19 14.06 13 74937 505 79668933
Illness 30.16 14.06 4 74946 46507 79622931
Change in seizure presentation 30.09 14.06 13 74937 509 79668929
Osteoporosis 29.99 14.06 7 74943 54105 79615333
Electrocardiogram ST-T segment elevation 29.85 14.06 5 74945 0 79669438
Bispectral index decreased 29.85 14.06 5 74945 0 79669438
Rash pruritic 29.82 14.06 15 74935 71614 79597824
Haemoglobin decreased 29.65 14.06 108 74842 222011 79447427
Muscle injury 29.60 14.06 5 74945 48556 79620882
Acute lung injury 29.52 14.06 24 74926 3076 79666362
Blood bicarbonate decreased 29.37 14.06 30 74920 5161 79664277
Productive cough 29.26 14.06 24 74926 88307 79581131
Laryngeal stenosis 29.03 14.06 16 74934 1072 79668366
Cellulitis 28.86 14.06 36 74914 109024 79560414
Transient ischaemic attack 28.84 14.06 7 74943 52688 79616750
Locked-in syndrome 28.75 14.06 14 74936 725 79668713
Intestinal pseudo-obstruction 28.72 14.06 22 74928 2587 79666851
Rhinorrhoea 28.69 14.06 18 74932 76056 79593382
Burkholderia test positive 28.67 14.06 13 74937 572 79668866
Sputum increased 28.57 14.06 28 74922 4585 79664853
Extrasystoles 28.44 14.06 35 74915 7384 79662054
Hepatic enzyme increased 28.38 14.06 83 74867 182527 79486911
Night sweats 28.36 14.06 7 74943 52088 79617350
Phaeochromocytoma crisis 28.34 14.06 11 74939 326 79669112
Heparin-induced thrombocytopenia 28.33 14.06 40 74910 9642 79659796
Brain herniation 28.28 14.06 35 74915 7428 79662010
Fibrinolysis 28.14 14.06 8 74942 86 79669352
Coma blister 28.10 14.06 10 74940 231 79669207
Multiple sclerosis relapse 27.90 14.06 5 74945 46528 79622910
Incorrect drug administration rate 27.90 14.06 26 74924 4000 79665438
Joint stiffness 27.74 14.06 3 74947 40827 79628611
Bronchial disorder 27.43 14.06 21 74929 2468 79666970
Ventricular dysfunction 27.38 14.06 31 74919 5992 79663446
Epistaxis 27.28 14.06 39 74911 111476 79557962
Viral infection 27.19 14.06 4 74946 43012 79626426
Coma scale abnormal 27.11 14.06 37 74913 8641 79660797
Maternal exposure during pregnancy 26.97 14.06 220 74730 136318 79533120
Apnoeic attack 26.91 14.06 13 74937 661 79668777
Hot flush 26.88 14.06 9 74941 54868 79614570
Hyperventilation 26.70 14.06 35 74915 7864 79661574
Cerebral ischaemia 26.67 14.06 42 74908 11153 79658285
Pupil fixed 26.60 14.06 24 74926 3542 79665896
Epilepsy with myoclonic-atonic seizures 26.47 14.06 8 74942 108 79669330
Respiratory alkalosis 26.39 14.06 26 74924 4285 79665153
Eye movement disorder 26.31 14.06 35 74915 7976 79661462
Polyuria 26.12 14.06 49 74901 14965 79654473
Transaminases increased 26.03 14.06 107 74843 51636 79617802
Pneumomediastinum 26.03 14.06 24 74926 3643 79665795
Adverse event 26.00 14.06 12 74938 60202 79609236
Gaze palsy 25.99 14.06 22 74928 2983 79666455
Vision blurred 25.94 14.06 37 74913 105861 79563577
Chemical peritonitis 25.94 14.06 10 74940 291 79669147
Atrioventricular block 25.90 14.06 47 74903 13994 79655444
Atrioventricular block first degree 25.88 14.06 44 74906 12447 79656991
Dialysis 25.81 14.06 55 74895 18407 79651031
Superinfection 25.35 14.06 27 74923 4875 79664563
Dysgeusia 25.30 14.06 11 74939 57166 79612272
Leukocytosis 25.22 14.06 94 74856 43361 79626077
Overdose 24.99 14.06 274 74676 183932 79485506
Malignant catatonia 24.92 14.06 11 74939 454 79668984
Hypotensive transfusion reaction 24.81 14.06 7 74943 73 79669365
Tongue oedema 24.78 14.06 32 74918 7085 79662353
Skin ulcer 24.63 14.06 10 74940 54140 79615298
Prinzmetal angina 24.62 14.06 17 74933 1703 79667735
Trismus 24.62 14.06 28 74922 5439 79663999
Extrapyramidal disorder 24.46 14.06 61 74889 22618 79646820
Blister 24.39 14.06 47 74903 119429 79550009
Lymphadenectomy 24.28 14.06 15 74935 1244 79668194
Product administered to patient of inappropriate age 24.26 14.06 28 74922 5525 79663913
Clonic convulsion 24.25 14.06 15 74935 1247 79668191
Procedural nausea 24.16 14.06 13 74937 830 79668608
Long QT syndrome congenital 24.09 14.06 8 74942 149 79669289
Osteoarthritis 23.97 14.06 28 74922 87281 79582157
Lymphadenopathy 23.95 14.06 10 74940 53237 79616201
Altered state of consciousness 23.95 14.06 93 74857 43729 79625709
Therapeutic response prolonged 23.88 14.06 4 74946 0 79669438
Haemodilution 23.85 14.06 8 74942 154 79669284
Blood potassium increased 23.83 14.06 71 74879 29204 79640234
Blood pressure fluctuation 23.82 14.06 17 74933 67128 79602310
Visual impairment 23.77 14.06 31 74919 92100 79577338
Abdominal compartment syndrome 23.37 14.06 16 74934 1581 79667857
Mucosal ulceration 23.31 14.06 17 74933 1856 79667582
Cardiovascular disorder 23.27 14.06 52 74898 17973 79651465
Osteonecrosis of jaw 23.16 14.06 6 74944 43220 79626218
Vitamin K deficiency 23.06 14.06 12 74938 716 79668722
Orthostatic hypotension 23.02 14.06 12 74938 56152 79613286
Blood pressure systolic decreased 22.93 14.06 39 74911 11037 79658401
Symptom masked 22.92 14.06 15 74935 1375 79668063
Myxoedema coma 22.92 14.06 12 74938 725 79668713
Mechanical ventilation complication 22.91 14.06 6 74944 46 79669392
Angina pectoris 22.82 14.06 10 74940 51722 79617716
Basal cell carcinoma 22.44 14.06 4 74946 37371 79632067
Nephrolithiasis 22.42 14.06 11 74939 53280 79616158
Myalgia 22.38 14.06 94 74856 185547 79483891
Pneumonia aspiration 22.37 14.06 123 74827 66844 79602594
Encephalitis autoimmune 22.36 14.06 18 74932 2276 79667162
Chest X-ray abnormal 22.23 14.06 32 74918 7851 79661587
Continuous haemodiafiltration 22.20 14.06 17 74933 1999 79667439
Respiratory tract infection 22.14 14.06 9 74941 48680 79620758
Cerebral hypoperfusion 22.14 14.06 12 74938 778 79668660
Procedural vomiting 22.12 14.06 12 74938 779 79668659
Dry eye 22.07 14.06 4 74946 36927 79632511
Cardiac massage 22.03 14.06 5 74945 19 79669419
Treatment failure 22.03 14.06 84 74866 170402 79499036
Injection site reaction 22.02 14.06 12 74938 54773 79614665
Intensive care unit delirium 21.96 14.06 6 74944 55 79669383
Memory impairment 21.91 14.06 45 74905 111689 79557749
Product use issue 21.89 14.06 112 74838 209710 79459728
Non-cardiogenic pulmonary oedema 21.89 14.06 15 74935 1484 79667954
Coronary artery embolism 21.84 14.06 9 74941 313 79669125
Eyelid oedema 21.76 14.06 43 74907 13644 79655794
Oesophageal intramural haematoma 21.73 14.06 7 74943 118 79669320
Sepsis syndrome 21.73 14.06 15 74935 1502 79667936
Femur fracture 21.42 14.06 5 74945 38647 79630791
Lip oedema 21.37 14.06 28 74922 6288 79663150
Throat irritation 21.34 14.06 6 74944 40940 79628498
Bezold-Jarisch reflex 21.26 14.06 5 74945 23 79669415
Anuria 21.17 14.06 55 74895 20908 79648530
Palmar-plantar erythrodysaesthesia syndrome 21.13 14.06 3 74947 33131 79636307
Muscle twitching 21.06 14.06 61 74889 24703 79644735
Left ventricular dysfunction 20.80 14.06 52 74898 19309 79650129
Gait inability 20.80 14.06 15 74935 58902 79610536
Obstructive airways disorder 20.78 14.06 71 74879 31388 79638050
CSWS syndrome 20.76 14.06 5 74945 26 79669412
Hyperammonaemic encephalopathy 20.70 14.06 24 74926 4758 79664680
Shock haemorrhagic 20.64 14.06 53 74897 20007 79649431
Burning sensation 20.60 14.06 15 74935 58617 79610821
Tracheal injury 20.58 14.06 6 74944 71 79669367
Normal newborn 20.37 14.06 29 74921 7043 79662395
Blood glucose increased 20.33 14.06 49 74901 114926 79554512
Pneumonia staphylococcal 20.33 14.06 24 74926 4850 79664588
Pancreatitis 20.32 14.06 122 74828 68453 79600985
Condition aggravated 20.30 14.06 340 74610 500784 79168654
Pain in jaw 20.23 14.06 9 74941 46142 79623296
Aspartate aminotransferase increased 20.09 14.06 209 74741 138432 79531006
Agitation postoperative 20.06 14.06 6 74944 78 79669360
Blood triglycerides increased 20.03 14.06 54 74896 20986 79648452
Amaurosis 20.00 14.06 13 74937 1178 79668260
Congestive hepatopathy 19.99 14.06 23 74927 4524 79664914
Hyperdynamic left ventricle 19.89 14.06 9 74941 394 79669044
Potentiating drug interaction 19.52 14.06 32 74918 8787 79660651
Chronic kidney disease 19.50 14.06 20 74930 66134 79603304
Fear of death 19.42 14.06 14 74936 1502 79667936
Euthyroid sick syndrome 19.27 14.06 6 74944 90 79669348
Transurethral resection syndrome 19.18 14.06 4 74946 9 79669429
Blood catecholamines increased 19.13 14.06 5 74945 38 79669400
Electrocardiogram abnormal 19.10 14.06 46 74904 16691 79652747
Joint range of motion decreased 19.06 14.06 4 74946 33278 79636160
Hypoglycaemia 19.01 14.06 42 74908 101552 79567886
Acute respiratory failure 18.99 14.06 108 74842 59433 79610005
Conversion disorder 18.98 14.06 15 74935 1846 79667592
Fat embolism 18.98 14.06 9 74941 439 79668999
Histamine level increased 18.80 14.06 6 74944 98 79669340
Device programming error 18.65 14.06 7 74943 189 79669249
Haematuria traumatic 18.61 14.06 7 74943 190 79669248
Electrocardiogram T wave inversion 18.46 14.06 24 74926 5348 79664090
Chills 18.46 14.06 231 74719 160003 79509435
Electrocardiogram repolarisation abnormality 18.39 14.06 16 74934 2251 79667187
Road traffic accident 18.39 14.06 9 74941 43655 79625783
Phaeochromocytoma 18.32 14.06 10 74940 657 79668781
Colitis ulcerative 18.28 14.06 5 74945 34737 79634701
Myocardial ischaemia 18.10 14.06 59 74891 25460 79643978
Capillary nail refill test abnormal 18.10 14.06 5 74945 48 79669390
Frequent bowel movements 18.09 14.06 3 74947 29536 79639902
Limb injury 18.08 14.06 3 74947 29525 79639913
Bronchostenosis 17.99 14.06 10 74940 681 79668757
Tryptase 17.91 14.06 3 74947 0 79669438
Renal tubular necrosis 17.86 14.06 58 74892 24981 79644457
Lung consolidation 17.86 14.06 31 74919 8916 79660522
Supraventricular extrasystoles 17.74 14.06 27 74923 6960 79662478
Product quality issue 17.72 14.06 71 74879 33869 79635569
Acquired macroglossia 17.71 14.06 7 74943 218 79669220
Nerve stimulation test abnormal 17.66 14.06 4 74946 15 79669423
Postoperative respiratory distress 17.66 14.06 4 74946 15 79669423
Hyperpyrexia 17.58 14.06 25 74925 6067 79663371
Glossoptosis 17.53 14.06 7 74943 224 79669214
Bundle branch block right 17.47 14.06 35 74915 11216 79658222
Red blood cell count decreased 17.40 14.06 17 74933 57496 79611942
Rectal haemorrhage 17.39 14.06 28 74922 76272 79593166
Neurological decompensation 17.33 14.06 23 74927 5230 79664208
Bradycardia foetal 17.31 14.06 6 74944 128 79669310
Laryngeal obstruction 17.27 14.06 6 74944 129 79669309
Pulmonary fibrosis 17.25 14.06 10 74940 44102 79625336
Idiopathic interstitial pneumonia 17.22 14.06 7 74943 235 79669203
Neuralgia 17.20 14.06 5 74945 33379 79636059
Nephrogenic diabetes insipidus 17.19 14.06 15 74935 2119 79667319
Ileus 17.17 14.06 59 74891 26152 79643286
Pancreatitis acute 17.17 14.06 92 74858 49512 79619926
Completed suicide 17.15 14.06 148 74802 245619 79423819
Prostate cancer 17.11 14.06 5 74945 33263 79636175
Acute myeloid leukaemia 17.10 14.06 4 74946 30881 79638557
Euthanasia 17.09 14.06 6 74944 133 79669305
Metastases to liver 17.07 14.06 3 74947 28311 79641127
Oedema 16.71 14.06 57 74893 119523 79549915
Tonic convulsion 16.68 14.06 15 74935 2205 79667233
Ventricular tachyarrhythmia 16.65 14.06 8 74942 402 79669036
Injection site swelling 16.63 14.06 12 74938 47120 79622318
Myotonic dystrophy 16.61 14.06 6 74944 145 79669293
Feeling hot 16.57 14.06 19 74931 59715 79609723
Hypertensive crisis 16.55 14.06 50 74900 20720 79648718
Malabsorption 16.55 14.06 22 74928 5010 79664428
Intentional self-injury 16.44 14.06 5 74945 32414 79637024
Retrograde amnesia 16.43 14.06 9 74941 596 79668842
Scoliosis 16.41 14.06 27 74923 7437 79662001
Eczema 16.32 14.06 9 74941 40809 79628629
Foetal heart rate decreased 16.27 14.06 4 74946 23 79669415
Therapeutic product effect decreased 16.23 14.06 89 74861 163774 79505664
Cytomegalovirus infection 16.20 14.06 10 74940 42634 79626804
Sputum retention 16.07 14.06 11 74939 1086 79668352
Gastroenteritis 15.99 14.06 6 74944 34076 79635362
Extubation 15.98 14.06 4 74946 25 79669413
Ammonia increased 15.96 14.06 27 74923 7608 79661830
Rash morbilliform 15.95 14.06 24 74926 6126 79663312
Abdominal pain lower 15.94 14.06 5 74945 31777 79637661
Neisseria infection 15.78 14.06 6 74944 168 79669270
Influenza like illness 15.71 14.06 27 74923 71680 79597758
Myocardial infarction 15.62 14.06 105 74845 184024 79485414
COVID-19 treatment 15.61 14.06 8 74942 462 79668976
Bone marrow failure 15.58 14.06 15 74935 51092 79618346
Uterine atony 15.45 14.06 6 74944 178 79669260
Eye pain 15.44 14.06 8 74942 37570 79631868
Muscle necrosis 15.41 14.06 12 74938 1446 79667992
Hypovolaemic shock 15.38 14.06 35 74915 12241 79657197
Light anaesthesia 15.37 14.06 3 74947 4 79669434
Central-alveolar hypoventilation 15.35 14.06 4 74946 30 79669408
Grimacing 15.31 14.06 9 74941 682 79668756
Multiple use of single-use product 15.31 14.06 10 74940 914 79668524
Pollakiuria 15.25 14.06 8 74942 37309 79632129
Arrhythmia supraventricular 15.25 14.06 14 74936 2113 79667325
Eyelid function disorder 15.19 14.06 7 74943 320 79669118
Decerebrate posture 15.09 14.06 6 74944 190 79669248
Documented hypersensitivity to administered product 15.08 14.06 10 74940 937 79668501
Toxicity to various agents 15.06 14.06 510 74440 421030 79248408
Dermatitis bullous 15.03 14.06 38 74912 14207 79655231
Weaning failure 15.03 14.06 9 74941 706 79668732
Product use in unapproved indication 14.99 14.06 324 74626 250035 79419403
Paraplegia 14.97 14.06 21 74929 5032 79664406
Somatosensory evoked potentials abnormal 14.97 14.06 6 74944 194 79669244
Iron deficiency anaemia 14.88 14.06 3 74947 25669 79643769
Compartment syndrome 14.88 14.06 21 74929 5061 79664377
Hemiplegic migraine 14.87 14.06 5 74945 97 79669341
Myocardial stunning 14.82 14.06 6 74944 199 79669239
Quadriplegia 14.78 14.06 17 74933 3343 79666095
Injection site haemorrhage 14.68 14.06 4 74946 27866 79641572
Lung neoplasm malignant 14.62 14.06 4 74946 27788 79641650
Blood pressure increased 14.43 14.06 128 74822 211232 79458206
Lipoedema 14.36 14.06 6 74944 216 79669222
Hypertonia 14.36 14.06 25 74925 7207 79662231
Dysuria 14.35 14.06 16 74934 50935 79618503
Lymphangiectasia 14.32 14.06 5 74945 109 79669329
Hypophagia 14.20 14.06 13 74937 45354 79624084
Acne 14.14 14.06 4 74946 27186 79642252
Posturing 14.12 14.06 10 74940 1043 79668395

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AX10 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:38877 intravenous anesthetics
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:50919 antiemetico
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Sedation in Intubated Patients indication
Sedation as Adjunct to Anesthesia indication
Apnea contraindication 1023001
Asthenia contraindication 13791008
Hypovolemia contraindication 28560003
Low blood pressure contraindication 45007003
Cerebral arteriosclerosis contraindication 65312002
Decreased respiratory function contraindication 80954004
Epilepsy contraindication 84757009 DOID:1826
Myocardial dysfunction contraindication 233928007
Disorder of lipid metabolism contraindication 267431006
Hypoxia contraindication 389086002




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Anesthesia Indication
Cats General anesthesia for short procedures Indication
Cats Induction and maintenance of general anesthesia Indication
Cats General anesthesia Indication
Dogs Anesthesia Indication
Dogs General anesthesia for short procedures Indication
Dogs Induction and maintenance of general anesthesia Indication
Dogs General anesthesia Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Rapanofal iVaoes Animal Health 1
PropoFlo, PropoFlo 28 Zoetis Inc. 1
PropoClear Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.70 CHEMBL CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 4.95 CHEMBL CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.39 CHEMBL CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.46 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.22 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 4.01 WOMBAT-PK
Carbonic anhydrase 1 Enzyme IC50 4.71 WOMBAT-PK
Cytochrome P450 2C9 Enzyme IC50 4.91 WOMBAT-PK
Transient receptor potential cation channel subfamily V member 4 Ion channel INHIBITOR IC50 4.41 IUPHAR
Fatty-acid amide hydrolase 1 Enzyme IC50 4.28 WOMBAT-PK
Transient receptor potential cation channel subfamily V member 4 Ion channel INHIBITOR IC50 4.41 IUPHAR
Prostaglandin G/H synthase 1 Enzyme IC50 5.42 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.03 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.12 DRUG MATRIX
Fatty-acid amide hydrolase 1 Enzyme IC50 4.85 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Ion channel BLOCKER IC50 5.20 IUPHAR
GABA-A receptor; anion channel Ion channel IC50 5.40 CHEMBL

External reference:

IDSource
4019500 VUID
N0000147620 NUI
D00549 KEGG_DRUG
4019500 VANDF
C0033487 UMLSCUI
CHEBI:44915 CHEBI
PFL PDB_CHEM_ID
CHEMBL526 ChEMBL_ID
DB00818 DRUGBANK_ID
D015742 MESH_DESCRIPTOR_UI
4943 PUBCHEM_CID
5073 INN_ID
5464 IUPHAR_LIGAND_ID
YI7VU623SF UNII
196459 RXNORM
14179 MMSL
5372 MMSL
65 MMSL
d00933 MMSL
003528 NDDF
387423006 SNOMEDCT_US
74674007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0209 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0209 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0234 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0234 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0248 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0248 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections
Propofol Lipuro HUMAN PRESCRIPTION DRUG LABEL 1 0264-4850 INJECTION, EMULSION 10 mg INTRAVENOUS unapproved drug other 3 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0404-9943 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 34 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 34 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 34 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-6010 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 34 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-6010 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 34 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0591-2136 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 31 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0591-2136 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 31 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0591-2136 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 31 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6194 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6194 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6195 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6195 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6196 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6196 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 16714-528 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 16714-690 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 16714-977 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Fresenius Propoven 2% HUMAN PRESCRIPTION DRUG LABEL 1 18124-027 EMULSION 20 mg INTRAVENOUS unapproved drug other 2 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 23155-345 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 23155-345 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 23155-345 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 32 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 25021-608 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 36 sections