pronetalol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatic ring -CH(-OH)-CH2-NH-R 2289 54-80-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pronethalol
  • (+/-)-Pronethalol
  • naphthylisoproterenol
  • nethalide
  • pronetalol
  • DL-Pronethalol
  • pronethalol hydrochloride
  • pronethalol HCl
  • Molecular weight: 229.32
  • Formula: C15H19NO
  • CLOGP: 2.59
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -3.35
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR Kd 6.80 CHEMBL

External reference:

IDSource
51-02-5 SECONDARY_CAS_RN
C0033424 UMLSCUI
CHEBI:8463 CHEBI
4930 PUBCHEM_CID
CHEMBL16476 ChEMBL_ID
C084832 MESH_SUPPLEMENTAL_RECORD_UI
1580 INN_ID
XBP4RT1IMQ UNII
001851 NDDF

Pharmaceutical products:

None