pregabalin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 2255 148553-50-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pregabalin
  • (S)-Pregabalin
  • gabanext
  • maxgalin
  • lyrica
  • pregabalin hydrochloride
  • pregabalin HCl
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.
  • Molecular weight: 159.23
  • Formula: C8H17NO2
  • CLOGP: -0.92
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.15
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 11.30 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 53.83 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.636 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.254 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.035 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 0.920 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 95.710 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 85.280 % High 1
herg hERG pIC50 5.310 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.340 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 2.938 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 96.150 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 43
kinase-selectivity-class CDK4,CHUK,EIF2AK3,MAP2K6,TEK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.606 High 1
mh-clint Mouse hepatocyte intrinsic clearance 6.295 High 1
mppb Mouse plasma protein binding (% unbound) 96.570 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.953 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 97.480 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.028 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 93.100 % High 1
rppb Rat plasma protein binding (% unbound) 97.580 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 885.116 uM High 1

Approvals:

DateAgencyCompanyOrphan
July 6, 2004 EMA
Dec. 30, 2004 FDA PF PRISM CV

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 1637.04 9.42 1163 464711 21361 90141212
Somnolence 1396.21 9.42 3223 462651 205861 89956712
Intentional product misuse 614.57 9.42 1397 464477 88207 90074366
Feeling abnormal 495.00 9.42 1934 463940 165301 89997272
Drug dependence 434.89 9.42 639 465235 28688 90133885
Sciatica 389.25 9.42 1277 464597 100105 90062468
Drug abuse 382.91 9.42 1109 464765 81238 90081335
Maternal exposure during pregnancy 362.83 9.42 822 465052 359241 89803332
Pemphigus 336.01 9.42 738 465136 326126 89836447
Drug withdrawal syndrome 310.65 9.42 542 465332 28181 90134392
Alopecia 278.28 9.42 1454 464420 493617 89668956
Exposure during pregnancy 277.84 9.42 500 465374 237910 89924663
Weight increased 275.35 9.42 3321 462553 414606 89747967
Tremor 273.70 9.42 1529 464345 151644 90010929
Coma 249.84 9.42 882 464992 71750 90090823
Insomnia 245.53 9.42 2708 463166 330766 89831807
Dizziness 244.77 9.42 4321 461553 584963 89577610
Gait disturbance 244.22 9.42 2224 463650 258272 89904301
Pain 243.31 9.42 6769 459105 989572 89173001
Abdominal discomfort 240.98 9.42 1452 464422 475876 89686697
Death 231.92 9.42 1386 464488 455165 89707408
Drug hypersensitivity 223.14 9.42 3483 462391 460126 89702447
Suicidal ideation 222.29 9.42 859 465015 72996 90089577
Vision blurred 215.95 9.42 1129 464745 109164 90053409
Road traffic accident 209.55 9.42 1100 464774 106526 90056047
Drug use disorder 209.37 9.42 236 465638 8107 90154466
Fall 209.27 9.42 3559 462315 478251 89684322
Disturbance in attention 207.07 9.42 622 465252 46487 90116086
Thinking abnormal 199.59 9.42 273 465601 11459 90151114
Euphoric mood 199.14 9.42 188 465686 5221 90157352
Neuralgia 198.22 9.42 475 465399 31025 90131548
Sopor 195.96 9.42 408 465466 24236 90138337
Feeling drunk 193.85 9.42 175 465699 4583 90157990
Anxiety 190.63 9.42 2431 463443 307341 89855232
Speech disorder 189.27 9.42 590 465284 44995 90117578
Impaired driving ability 185.13 9.42 177 465697 4996 90157577
Anti-cyclic citrullinated peptide antibody positive 184.58 9.42 611 465263 235822 89926751
Systemic lupus erythematosus 184.55 9.42 1097 464777 360799 89801774
Memory impairment 181.22 9.42 1677 464197 195567 89967006
Pericarditis 180.83 9.42 744 465130 269407 89893166
Dysarthria 172.45 9.42 644 465230 53838 90108735
Hypoacusis 170.99 9.42 416 465458 27434 90135139
Depressed level of consciousness 168.09 9.42 781 465093 72003 90090570
Device expulsion 166.77 9.42 11 465863 40875 90121698
Therapeutic product effect incomplete 165.94 9.42 1624 464250 192272 89970301
Injection site pain 165.60 9.42 408 465466 173291 89989282
Myoclonus 160.26 9.42 324 465550 18844 90143729
Glossodynia 158.99 9.42 985 464889 320794 89841779
Prescribed overdose 155.78 9.42 946 464928 96679 90065894
Confusional state 151.58 9.42 2808 463066 383397 89779176
Injection site reaction 147.65 9.42 153 465721 91927 90070646
Malaise 141.23 9.42 3977 461897 582009 89580564
Impaired work ability 139.89 9.42 308 465566 19018 90143555
Pre-existing condition improved 136.23 9.42 200 465674 8969 90153604
Coordination abnormal 135.40 9.42 323 465551 21033 90141540
Disorientation 135.10 9.42 516 465358 43598 90118975
Burning sensation 135.01 9.42 665 465209 62787 90099786
Diarrhoea 134.78 9.42 3738 462136 935452 89227121
Hypoaesthesia 131.50 9.42 2308 463566 311902 89850671
Prescription drug used without a prescription 131.20 9.42 119 465755 3136 90159437
Substance use disorder 130.14 9.42 97 465777 1923 90160650
Altered state of consciousness 129.86 9.42 407 465467 31125 90131448
Premature delivery 128.81 9.42 22 465852 38740 90123833
Neutropenia 125.28 9.42 662 465212 224242 89938331
Product quality issue 122.51 9.42 136 465738 79189 90083384
Pain in extremity 121.40 9.42 3103 462771 447426 89715147
Hand deformity 120.93 9.42 959 464915 295403 89867170
Balance disorder 120.07 9.42 883 464991 96197 90066376
Body height decreased 119.59 9.42 218 465656 11731 90150842
Myelosuppression 119.58 9.42 63 465811 53528 90109045
Dyskinesia 117.41 9.42 434 465440 36100 90126473
Contraindicated product administered 116.27 9.42 1068 464806 319071 89843502
Visual impairment 114.35 9.42 1111 464763 131254 90031319
Macular degeneration 112.08 9.42 439 465435 37531 90125042
Restlessness 107.08 9.42 415 465459 35305 90127268
Arthropathy 106.89 9.42 1286 464588 364956 89797617
Respiratory depression 106.88 9.42 243 465631 15332 90147241
Product dispensing error 106.86 9.42 211 465663 12062 90150511
Injection site erythema 106.42 9.42 216 465658 98286 90064287
Therapeutic response unexpected 104.87 9.42 298 465576 21582 90140991
Oedema peripheral 104.49 9.42 1885 463989 256030 89906543
Hallucination, visual 104.41 9.42 308 465566 22784 90139789
Intentional overdose 102.97 9.42 830 465044 93004 90069569
Personality disorder 102.44 9.42 209 465665 12235 90150338
Overdose 100.43 9.42 1246 464628 156463 90006110
Onychomadesis 99.83 9.42 56 465818 45942 90116631
International normalised ratio fluctuation 99.80 9.42 100 465774 2993 90159580
Loss of consciousness 99.44 9.42 1131 464743 139107 90023466
Onychomycosis 99.28 9.42 34 465840 37342 90125231
Muscle twitching 97.47 9.42 310 465564 23892 90138681
Deep vein thrombosis postoperative 96.86 9.42 660 465214 70149 90092424
Amnesia 96.81 9.42 917 464957 107588 90054985
Hyperhidrosis 96.52 9.42 1099 464775 135206 90027367
Lower limb fracture 96.02 9.42 757 465117 84256 90078317
Vertigo 95.67 9.42 651 465223 69160 90093413
Movement disorder 95.16 9.42 347 465527 28672 90133901
Febrile neutropenia 95.06 9.42 454 465420 157895 90004678
Injection site swelling 93.06 9.42 102 465772 59737 90102836
Pneumonia aspiration 91.36 9.42 435 465439 40505 90122068
C-reactive protein 91.24 9.42 361 465513 31006 90131567
Finger deformity 90.78 9.42 28 465846 32869 90129704
Gastrointestinal haemorrhage 90.75 9.42 206 465668 90042 90072531
Blepharospasm 90.16 9.42 91 465783 55354 90107219
Gangrene 89.59 9.42 202 465672 12674 90149899
Autoimmune disorder 87.57 9.42 685 465189 76059 90086514
Mental impairment 87.34 9.42 235 465639 16485 90146088
Irritability 87.03 9.42 389 465485 35273 90127300
Crying 86.94 9.42 310 465564 25335 90137238
Therapeutic product effect decreased 86.65 9.42 960 464914 276611 89885962
Sensory loss 86.46 9.42 246 465628 17829 90144744
Product dose omission issue 86.30 9.42 1021 464853 290666 89871907
Nail disorder 86.12 9.42 106 465768 58961 90103612
Substance abuse 84.81 9.42 121 465753 5285 90157288
Wound 83.80 9.42 1076 464798 301904 89860669
Dysstasia 83.36 9.42 301 465573 24751 90137822
Taste disorder 82.04 9.42 118 465756 61428 90101145
Agitation 81.65 9.42 608 465266 66490 90096083
Dry mouth 81.26 9.42 1364 464510 182695 89979878
Bloody discharge 80.17 9.42 77 465797 2186 90160387
White blood cell count decreased 80.15 9.42 516 465358 166593 89995980
Affect lability 76.09 9.42 235 465639 17828 90144745
Suicide attempt 74.77 9.42 652 465222 74747 90087826
Aggression 74.43 9.42 303 465571 26365 90136208
Miosis 73.05 9.42 155 465719 9329 90153244
Multiple organ dysfunction syndrome 72.83 9.42 151 465723 68185 90094388
Carotid artery thrombosis 72.83 9.42 151 465723 8941 90153632
Disease progression 72.38 9.42 489 465385 156126 90006447
Dyspnoea 71.40 9.42 3752 462122 877203 89285370
Arterial occlusive disease 71.22 9.42 181 465693 12265 90150308
Loss of personal independence in daily activities 70.45 9.42 1036 464838 135069 90027504
Haemoglobin decreased 70.28 9.42 515 465359 161441 90001132
Adjustment disorder 67.91 9.42 152 465722 9490 90153083
Hallucination 67.83 9.42 575 465299 65384 90097189
Neurologic neglect syndrome 67.46 9.42 144 465730 8703 90153870
Cataract 67.17 9.42 615 465259 71477 90091096
Rash 66.69 9.42 3379 462495 792721 89369852
Platelet count decreased 66.67 9.42 421 465453 136548 90026025
Motor dysfunction 66.51 9.42 234 465640 18996 90143577
Expired product administered 66.40 9.42 124 465750 6798 90155775
Premature baby 66.28 9.42 23 465851 25054 90137519
Hospitalisation 65.87 9.42 387 465487 127713 90034860
Pancytopenia 65.26 9.42 357 465517 119906 90042667
Cognitive disorder 64.62 9.42 592 465282 68815 90093758
Synovitis 64.56 9.42 1250 464624 328502 89834071
Cytomegalovirus infection 64.35 9.42 28 465846 26574 90135999
Nervousness 64.14 9.42 345 465529 33711 90128862
Sleep disorder 63.93 9.42 1399 464475 196631 89965942
Product label confusion 63.86 9.42 19 465855 22831 90139742
Neutrophil count decreased 63.56 9.42 174 465700 71358 90091215
Product prescribing error 63.45 9.42 315 465559 29830 90132743
Lyme disease 63.37 9.42 93 465781 4169 90158404
Discomfort 63.26 9.42 1010 464864 273325 89889248
Diplopia 61.83 9.42 302 465572 28412 90134161
Hyperaesthesia 61.62 9.42 156 465718 10546 90152027
Septic shock 61.23 9.42 224 465650 83936 90078637
Off label use 61.13 9.42 4859 461015 1097393 89065180
Lower respiratory tract infection 60.78 9.42 914 464960 249745 89912828
Accidental exposure to product 60.75 9.42 77 465797 42289 90120284
Intervertebral disc protrusion 60.70 9.42 289 465585 26907 90135666
Bradypnoea 59.87 9.42 95 465779 4563 90158010
Delirium 59.47 9.42 808 465066 103551 90059022
Aphasia 59.11 9.42 400 465474 42412 90120161
Dependence 59.06 9.42 63 465811 2032 90160541
Neoplasm progression 58.60 9.42 86 465788 44400 90118173
Liver disorder 58.47 9.42 912 464962 120357 90042216
Sepsis 58.45 9.42 616 465258 179198 89983375
Muscular weakness 56.88 9.42 1428 464446 205238 89957335
Mucosal inflammation 56.75 9.42 133 465741 57492 90105081
Stomatitis 56.64 9.42 1032 464842 273666 89888907
Foetal exposure during pregnancy 54.75 9.42 85 465789 42890 90119683
Pulmonary hypertension 54.27 9.42 84 465790 42439 90120134
Eating disorder 53.97 9.42 286 465588 27787 90134786
Multiple sclerosis 51.73 9.42 281 465593 27559 90135014
Anaemia 51.66 9.42 1399 464475 351403 89811170
Dysgraphia 51.37 9.42 78 465796 3605 90158968
Poor quality sleep 50.54 9.42 256 465618 24437 90138136
Atrial fibrillation 50.51 9.42 441 465433 133170 90029403
Infusion related reaction 50.35 9.42 1696 464178 415084 89747489
International normalised ratio increased 50.04 9.42 105 465769 47211 90115362
Sensitivity to weather change 49.32 9.42 128 465746 8786 90153787
Injection site pruritus 49.30 9.42 129 465745 53705 90108868
Swollen joint count increased 48.64 9.42 823 465051 110383 90052190
Sedation 48.51 9.42 418 465456 47753 90114820
Bradyphrenia 48.11 9.42 115 465759 7497 90155076
Depression 47.93 9.42 1945 463929 298656 89863917
Rheumatoid factor negative 47.76 9.42 33 465841 578 90161995
Mydriasis 47.12 9.42 177 465697 14835 90147738
Hemiplegia 47.01 9.42 186 465688 15974 90146599
Hypersensitivity 46.68 9.42 1887 463987 452790 89709783
Intentional self-injury 46.61 9.42 284 465590 29050 90133523
Blood iron abnormal 46.27 9.42 78 465796 3942 90158631
Fibromyalgia 46.21 9.42 1388 464486 204881 89957692
Hepatotoxicity 44.98 9.42 106 465768 45736 90116837
Back injury 44.80 9.42 109 465765 46513 90116060
Dysphemia 44.22 9.42 66 465808 3004 90159569
Nightmare 43.60 9.42 224 465650 21501 90141072
Torsade de pointes 43.58 9.42 12 465862 15170 90147403
Acute myocardial infarction 43.51 9.42 70 465804 34820 90127753
Feeling of despair 43.48 9.42 67 465807 3137 90159436
Device dislocation 43.31 9.42 59 465815 31423 90131150
Increased appetite 43.16 9.42 146 465728 11619 90150954
Tension 43.13 9.42 72 465802 3610 90158963
Injection site bruising 42.99 9.42 132 465742 52175 90110398
Drug resistance 42.97 9.42 56 465818 30393 90132180
Swelling 42.83 9.42 1740 464134 417318 89745255
Arthritis 42.79 9.42 1145 464729 166170 89996403
Cardiac failure congestive 42.73 9.42 314 465560 98380 90064193
Breakthrough pain 42.68 9.42 44 465830 1363 90161210
Red blood cell sedimentation rate abnormal 42.56 9.42 37 465837 24167 90138406
Drug interaction 42.52 9.42 1782 464092 274671 89887902
Allodynia 42.38 9.42 38 465836 986 90161587
Renal failure 41.67 9.42 451 465423 130556 90032017
Formication 41.26 9.42 82 465792 4709 90157864
Bezoar 41.14 9.42 60 465814 2674 90159899
Abnormal behaviour 41.11 9.42 227 465647 22401 90140172
Haematocrit decreased 40.83 9.42 97 465777 41735 90120838
Therapy interrupted 40.79 9.42 127 465747 49981 90112592
Bedridden 40.45 9.42 146 465728 12002 90150571
COVID-19 40.11 9.42 618 465256 168225 89994348
Device difficult to use 39.99 9.42 20 465854 17505 90145068
Urinary retention 39.84 9.42 331 465543 37413 90125160
Fatigue 39.74 9.42 5263 460611 1148760 89013813
Ataxia 39.74 9.42 191 465683 17851 90144722
Wrong technique in product usage process 39.62 9.42 211 465663 71360 90091213
Left ventricular dysfunction 39.56 9.42 13 465861 14656 90147917
Hostility 38.82 9.42 53 465821 2220 90160353
Hypervolaemia 38.74 9.42 68 465806 32689 90129884
Arthralgia 38.50 9.42 3462 462412 775060 89387513
Rheumatoid arthritis 38.38 9.42 2254 463620 360360 89802213
Synovial fluid analysis 38.35 9.42 59 465815 2759 90159814
Hepatic enzyme increased 38.33 9.42 1491 464383 359245 89803328
Nerve injury 38.28 9.42 135 465739 10971 90151602
Libido increased 38.19 9.42 46 465828 1698 90160875
Cough 38.12 9.42 1530 464344 367432 89795141
Hypomagnesaemia 37.61 9.42 79 465795 35509 90127064
Premature labour 37.60 9.42 11 465863 13365 90149208
Therapy cessation 37.36 9.42 82 465792 36279 90126294
Coronary artery disease 36.93 9.42 73 465801 33550 90129023
Skin haemorrhage 36.54 9.42 211 465663 21169 90141404
Hypersomnia 36.48 9.42 212 465662 21319 90141254
Dysaesthesia 36.07 9.42 82 465792 5173 90157400
Oropharyngeal pain 36.05 9.42 398 465476 114789 90047784
Red blood cell sedimentation rate increased 36.02 9.42 611 465263 81984 90080589
Blister 35.55 9.42 1018 464856 253980 89908593
Total lung capacity decreased 35.18 9.42 67 465807 3728 90158845
Pre-eclampsia 35.14 9.42 7 465867 11041 90151532
Inadequate analgesia 35.06 9.42 61 465813 3163 90159410
Full blood count abnormal 34.82 9.42 86 465788 36511 90126062
Full blood count decreased 34.78 9.42 62 465812 29627 90132946
Pneumocystis jirovecii pneumonia 34.55 9.42 36 465838 21580 90140993
Caesarean section 34.39 9.42 27 465847 18550 90144023
Pleural effusion 34.24 9.42 389 465485 111602 90050971
Injection site haemorrhage 34.21 9.42 58 465816 28260 90134313
Ascites 34.11 9.42 128 465746 47612 90114961
Epistaxis 33.95 9.42 277 465597 84848 90077725
Eye pruritus 33.66 9.42 61 465813 28966 90133607
Spinal disorder 33.63 9.42 134 465740 11545 90151028
Trigeminal neuralgia 33.55 9.42 69 465805 4062 90158511
Acute myeloid leukaemia 33.41 9.42 34 465840 20606 90141967
Affective disorder 33.39 9.42 102 465772 7691 90154882
Systemic infection 33.32 9.42 75 465799 4700 90157873
Parkinsonism 33.25 9.42 152 465722 13913 90148660
Feeling of body temperature change 33.21 9.42 83 465791 5566 90157007
Respiratory failure 32.90 9.42 420 465454 117998 90044575
Apathy 32.87 9.42 128 465746 10912 90151661
Cytopenia 32.76 9.42 25 465849 17424 90145149
Blood calcium decreased 32.75 9.42 66 465808 30116 90132457
Negative thoughts 32.73 9.42 34 465840 1063 90161510
Leukocytosis 32.58 9.42 69 465805 30921 90131652
No adverse event 32.53 9.42 210 465664 67772 90094801
Emotional disorder 32.48 9.42 158 465716 14839 90147734
Nasal polyps 32.37 9.42 8 465866 10872 90151701
Pulmonary arterial hypertension 32.22 9.42 53 465821 26134 90136439
Aspergillus infection 32.12 9.42 8 465866 10815 90151758
Tenosynovitis stenosans 32.07 9.42 66 465808 3887 90158686
Pleuritic pain 31.72 9.42 122 465752 10339 90152234
Pericardial effusion 31.68 9.42 91 465783 36742 90125831
Depressed mood 31.60 9.42 396 465478 49826 90112747
Ejection fraction decreased 31.50 9.42 54 465820 26199 90136374
Visual acuity reduced 31.29 9.42 217 465657 23193 90139380
Prescribed underdose 31.29 9.42 551 465323 74468 90088105
Multiple sclerosis relapse 31.04 9.42 408 465466 51897 90110676
Dry skin 30.98 9.42 296 465578 87777 90074796
Antinuclear antibody positive 30.72 9.42 111 465763 9130 90153443
Body tinea 30.68 9.42 46 465828 2102 90160471
Cytokine release syndrome 30.49 9.42 61 465813 27912 90134661
Restless legs syndrome 30.45 9.42 209 465665 22261 90140312
Panic attack 30.44 9.42 236 465638 26129 90136444
Low birth weight baby 30.11 9.42 6 465868 9461 90153112
Diabetic neuropathy 29.88 9.42 70 465804 4504 90158069
Productive cough 29.72 9.42 253 465621 76810 90085763
Foetal growth restriction 29.72 9.42 6 465868 9374 90153199
Hypotension 29.71 9.42 1368 464506 324029 89838544
Product preparation error 29.66 9.42 8 465866 10253 90152320
Pseudomonas infection 29.61 9.42 20 465854 14845 90147728
Pneumonia 29.56 9.42 2851 463023 635208 89527365
Hypokinesia 29.54 9.42 159 465715 15538 90147035
Drug dose omission by device 29.53 9.42 8 465866 10223 90152350
Central obesity 29.36 9.42 36 465838 1354 90161219
Cytomegalovirus infection reactivation 29.32 9.42 3 465871 7797 90154776
Acute respiratory distress syndrome 29.22 9.42 65 465809 28621 90133952
Angina pectoris 29.18 9.42 319 465555 38841 90123732
Spinal stenosis 29.16 9.42 171 465703 17253 90145320
Gait inability 28.98 9.42 971 464903 145485 90017088
Malignant neoplasm progression 28.96 9.42 381 465493 106489 90056084
Myelodysplastic syndrome 28.93 9.42 39 465835 20864 90141709
Flushing 28.80 9.42 303 465571 88188 90074385
Coagulopathy 28.78 9.42 47 465827 23242 90139331
Oedema 28.75 9.42 1282 464592 199013 89963560
Panic reaction 28.46 9.42 70 465804 4647 90157926
Bronchopulmonary aspergillosis allergic 28.37 9.42 61 465813 3705 90158868
Somnambulism 28.09 9.42 83 465791 6145 90156428
Defaecation disorder 28.09 9.42 29 465845 900 90161673
Anger 27.91 9.42 142 465732 13578 90148995
Proteinuria 27.86 9.42 48 465826 23243 90139330
Injection site rash 27.85 9.42 51 465823 24122 90138451
Device breakage 27.83 9.42 19 465855 14025 90148548
Cardiac arrest 27.75 9.42 376 465498 104559 90058014
Injection site urticaria 27.67 9.42 31 465843 17980 90144593
Abnormal dreams 27.62 9.42 123 465751 11134 90151439
Reduced facial expression 27.37 9.42 48 465826 2505 90160068
Ankle fracture 27.33 9.42 189 465685 20181 90142392
Device malfunction 27.19 9.42 41 465833 20936 90141637
Colour blindness acquired 27.18 9.42 14 465860 138 90162435
Behaviour disorder 27.14 9.42 68 465806 4567 90158006
Persistent genital arousal disorder 27.06 9.42 25 465849 675 90161898
Blood bilirubin increased 27.03 9.42 123 465751 43347 90119226
Sneezing 26.91 9.42 253 465621 29616 90132957
Rhinitis allergic 26.78 9.42 28 465846 16757 90145816
Photophobia 26.59 9.42 194 465680 21075 90141498
Thrombotic microangiopathy 26.56 9.42 25 465849 15718 90146855
Toxicity to various agents 26.52 9.42 1768 464106 286078 89876495
Abdominal distension 26.47 9.42 492 465382 130109 90032464
Tenderness 26.45 9.42 232 465642 26636 90135937
Right ventricular failure 26.41 9.42 36 465838 19169 90143404
Metastases to liver 26.40 9.42 69 465805 28738 90133835
Temperature regulation disorder 26.31 9.42 146 465728 14433 90148140
Cholelithiasis 26.26 9.42 160 465714 52346 90110227
Pulmonary oedema 26.16 9.42 199 465675 61881 90100692
Device issue 26.12 9.42 72 465802 29465 90133108
Ventricular tachycardia 25.99 9.42 55 465819 24653 90137920
Grip strength 25.93 9.42 103 465771 8862 90153711
Intervertebral disc disorder 25.81 9.42 74 465800 5386 90157187
Fungal infection 25.77 9.42 122 465752 42539 90120034
Unintentional medical device removal 25.67 9.42 3 465871 7027 90155546
Telangiectasia congenital 25.50 9.42 8 465866 16 90162557
Adverse drug reaction 25.44 9.42 434 465440 116267 90046306
Substance use 25.24 9.42 31 465843 1168 90161405
Complication associated with device 25.22 9.42 38 465836 19411 90143162
Anorgasmia 25.14 9.42 24 465850 676 90161897
Neurosis 25.09 9.42 19 465855 386 90162187
Crepitations 25.04 9.42 101 465773 8751 90153822
Palmar-plantar erythrodysaesthesia syndrome 25.01 9.42 68 465806 27955 90134618
Sensory disturbance 24.98 9.42 150 465724 15263 90147310
Dyspnoea exertional 24.98 9.42 244 465630 72044 90090529
Myocardial infarction 24.78 9.42 389 465485 105583 90056990
Inhibitory drug interaction 24.72 9.42 52 465822 3111 90159462
Visual field defect 24.61 9.42 87 465787 7079 90155494
Sickle cell anaemia with crisis 24.56 9.42 4 465870 7293 90155280
Haemophagocytic lymphohistiocytosis 24.42 9.42 26 465848 15433 90147140
Muscle injury 24.41 9.42 706 465168 175948 89986625
Aspiration 24.34 9.42 151 465723 15542 90147031
Device use error 24.21 9.42 4 465870 7217 90155356
Mood altered 24.15 9.42 161 465713 16983 90145590
Oligohydramnios 24.12 9.42 4 465870 7197 90155376
Ventricular fibrillation 24.05 9.42 22 465852 14022 90148551
Poisoning 23.97 9.42 147 465727 15070 90147503
Muscle spasms 23.89 9.42 1551 464323 250332 89912241
Frustration tolerance decreased 23.87 9.42 92 465782 7804 90154769
Hospice care 23.81 9.42 10 465864 9694 90152879
Uterine perforation 23.58 9.42 5 465869 7549 90155024
Creatinine renal clearance decreased 23.48 9.42 38 465836 18861 90143712
Limb discomfort 23.47 9.42 299 465575 37761 90124812
Breast cancer 23.28 9.42 171 465703 53590 90108983
Ulcer 23.20 9.42 265 465609 32617 90129956
Infective pulmonary exacerbation of cystic fibrosis 23.05 9.42 12 465862 10267 90152306
Injection site warmth 22.93 9.42 34 465840 17481 90145092
Deep vein thrombosis 22.90 9.42 332 465542 91288 90071285
Priapism 22.90 9.42 12 465862 123 90162450
Nephropathy toxic 22.79 9.42 19 465855 12669 90149904
Peroneal nerve palsy 22.58 9.42 73 465801 5675 90156898
Small intestinal obstruction 22.56 9.42 47 465827 21187 90141386
Back pain 22.47 9.42 1908 463966 315267 89847306
Aplastic anaemia 22.47 9.42 21 465853 13248 90149325
Maternal exposure before pregnancy 22.45 9.42 15 465859 11198 90151375
Glomerular filtration rate increased 22.44 9.42 39 465835 2021 90160552
Herpes zoster 22.30 9.42 641 465233 94003 90068570
Mental disorder 22.15 9.42 259 465615 32059 90130514
Accidental poisoning 22.14 9.42 26 465848 934 90161639
Lupus vulgaris 22.14 9.42 340 465534 44719 90117854
Radiculopathy 22.12 9.42 167 465707 18338 90144235
Myofascial pain syndrome 21.85 9.42 48 465826 2959 90159614
Pneumonia viral 21.80 9.42 9 465865 8814 90153759
Cytomegalovirus viraemia 21.77 9.42 6 465868 7580 90154993
Hypoalbuminaemia 21.66 9.42 30 465844 15867 90146706
Throat irritation 21.52 9.42 154 465720 48541 90114032
Logorrhoea 21.50 9.42 45 465829 2682 90159891
Nasal congestion 21.30 9.42 301 465573 83113 90079460
Scleritis 21.24 9.42 67 465807 5141 90157432
Infusion site reaction 21.20 9.42 41 465833 18998 90143575
Dysuria 21.20 9.42 302 465572 39099 90123474
Sinus congestion 21.18 9.42 225 465649 27199 90135374
Anaphylactic shock 21.16 9.42 87 465787 31530 90131043
Vascular access site thrombosis 21.11 9.42 9 465865 55 90162518
Middle insomnia 21.06 9.42 153 465721 16598 90145975
Vascular access site infection 20.99 9.42 10 465864 82 90162491
Psychomotor hyperactivity 20.96 9.42 125 465749 12688 90149885
Drug screen positive 20.84 9.42 54 465820 3703 90158870
Thirst decreased 20.80 9.42 16 465858 333 90162240
Inappropriate schedule of product administration 20.77 9.42 599 465275 149334 90013239
Granulocytopenia 20.66 9.42 4 465870 6437 90156136
Reading disorder 20.52 9.42 27 465847 1091 90161482
Epstein-Barr virus infection 20.49 9.42 14 465860 10330 90152243
Victim of chemical submission 20.44 9.42 22 465852 717 90161856
Skull fracture 20.16 9.42 29 465845 1276 90161297
Hiatus hernia 20.13 9.42 65 465809 25296 90137277
Cervix neoplasm 20.09 9.42 13 465861 203 90162370
Posterior reversible encephalopathy syndrome 20.09 9.42 54 465820 22285 90140288
Paralysis 20.09 9.42 114 465760 11364 90151209
Nervous system disorder 20.00 9.42 184 465690 21409 90141164
Heart rate increased 19.97 9.42 435 465439 112467 90050106
Blood creatinine increased 19.90 9.42 384 465490 101002 90061571
Haematotoxicity 19.89 9.42 21 465853 12514 90150059
Fracture 19.89 9.42 187 465687 21889 90140684
Complication of device removal 19.82 9.42 4 465870 6251 90156322
Sternal fracture 19.76 9.42 45 465829 2842 90159731
Ophthalmic herpes zoster 19.69 9.42 44 465830 2744 90159829
Lung infiltration 19.68 9.42 30 465844 15252 90147321
Granuloma 19.50 9.42 4 465870 6181 90156392
Clostridium difficile colitis 19.47 9.42 71 465803 26635 90135938
Multiple allergies 19.43 9.42 139 465735 15007 90147566
Illusion 19.40 9.42 28 465846 1236 90161337
Procedural pain 19.29 9.42 259 465615 33101 90129472
Drug screen false positive 19.24 9.42 24 465850 919 90161654
Limb injury 19.21 9.42 247 465627 31261 90131312
Normal newborn 19.16 9.42 59 465815 23303 90139270
Rib fracture 19.08 9.42 214 465660 26221 90136352
Orthostatic tremor 19.04 9.42 5 465869 3 90162570
Fear of injection 19.01 9.42 10 465864 8505 90154068
Ill-defined disorder 19 9.42 767 465107 184124 89978449
Psychomotor retardation 18.97 9.42 61 465813 4728 90157845
Chromatopsia 18.94 9.42 18 465856 504 90162069
Pathogen resistance 18.91 9.42 9 465865 8106 90154467
Labelled drug-drug interaction medication error 18.80 9.42 134 465740 14448 90148125
Incorrect product administration duration 18.70 9.42 45 465829 19277 90143296
Accidental overdose 18.68 9.42 225 465649 28048 90134525
Aspartate aminotransferase increased 18.68 9.42 395 465479 102542 90060031
Laryngeal disorder 18.55 9.42 26 465848 1117 90161456
Cardiogenic shock 18.54 9.42 64 465810 24404 90138169
Synovial disorder 18.53 9.42 46 465828 3072 90159501
Bacteraemia 18.52 9.42 56 465818 22244 90140329
Body temperature increased 18.51 9.42 144 465730 44566 90118007
Acute hepatic failure 18.49 9.42 57 465817 22504 90140069
Hemiparesis 18.38 9.42 247 465627 31572 90131001
Clostridium difficile infection 18.36 9.42 110 465764 36135 90126438
Infection susceptibility increased 18.36 9.42 53 465821 3873 90158700
Eosinophilic colitis 18.18 9.42 13 465861 241 90162332
Sinus disorder 18.12 9.42 263 465611 34184 90128389
Leukopenia 18.11 9.42 387 465487 100323 90062250
Second primary malignancy 18.08 9.42 16 465858 10362 90152211
Cardiomyopathy 18.06 9.42 49 465825 20157 90142416
Sputum discoloured 18.01 9.42 172 465702 20219 90142354
Feeling jittery 17.97 9.42 138 465736 15233 90147340
Melaena 17.94 9.42 105 465769 34692 90127881
Orthostatic intolerance 17.94 9.42 28 465846 1326 90161247
Distractibility 17.90 9.42 18 465856 541 90162032
Subarachnoid haemorrhage 17.89 9.42 41 465833 17863 90144710
Hyperprolactinaemia 17.84 9.42 65 465809 5368 90157205
Contrast media allergy 17.83 9.42 45 465829 3036 90159537
Chronic sinusitis 17.78 9.42 194 465680 23608 90138965
Pituitary tumour benign 17.78 9.42 36 465838 2096 90160477
Heparin-induced thrombocytopenia 17.68 9.42 3 465871 5309 90157264
Gestational diabetes 17.63 9.42 17 465857 10565 90152008
Spinal pain 17.57 9.42 140 465734 15627 90146946
Graft versus host disease 17.55 9.42 10 465864 8134 90154439
Tissue infiltration 17.52 9.42 22 465852 848 90161725
Psoriatic arthropathy 17.52 9.42 1382 464492 226953 89935620
Urinary tract infection 17.48 9.42 1343 464531 304289 89858284
Acute respiratory failure 17.41 9.42 139 465735 42779 90119794
Malnutrition 17.35 9.42 44 465830 18514 90144059
Adverse reaction 17.35 9.42 86 465788 29626 90132947
Duodenal ulcer perforation 17.34 9.42 945 464929 220343 89942230
Glaucoma 17.32 9.42 173 465701 20582 90141991
Retinitis 17.32 9.42 286 465588 38172 90124401
Post cholecystectomy syndrome 17.30 9.42 22 465852 859 90161714
Hypocalcaemia 17.29 9.42 137 465737 42231 90120342
Electrocardiogram QT prolonged 17.27 9.42 265 465609 72191 90090382
Eyelid injury 17.21 9.42 11 465863 168 90162405
Spinal osteoarthritis 17.15 9.42 162 465712 18986 90143587
Chest discomfort 17.15 9.42 561 465313 137804 90024769
Seizure 17.13 9.42 954 464920 151675 90010898
Carcinoid tumour pulmonary 17.12 9.42 17 465857 503 90162070
Anxiety disorder 17.11 9.42 60 465814 4862 90157711
Complication of device insertion 17.11 9.42 17 465857 10419 90152154
Bronchopulmonary aspergillosis 17.10 9.42 20 465854 11378 90151195
Soft tissue injury 17.06 9.42 35 465839 2057 90160516
Intentional product use issue 17.01 9.42 1315 464559 215577 89946996
Unintended pregnancy 17.00 9.42 9 465865 7628 90154945
Post-traumatic neck syndrome 17.00 9.42 39 465835 2475 90160098
Organising pneumonia 16.84 9.42 9 465865 7588 90154985
Hyperglycaemia 16.80 9.42 174 465700 50796 90111777
Nail growth abnormal 16.79 9.42 18 465856 584 90161989
Gastrointestinal disorder 16.78 9.42 1115 464759 255572 89907001
Haemorrhage 16.77 9.42 253 465621 69116 90093457
Substance dependence 16.72 9.42 11 465863 177 90162396
Joint swelling 16.66 9.42 2300 463574 501000 89661573
Abortion induced 16.64 9.42 22 465852 11866 90150707
Foaming at mouth 16.62 9.42 27 465847 1323 90161250
Monoplegia 16.60 9.42 49 465825 3625 90158948
Porphyria acute 16.56 9.42 153 465721 17822 90144751
Dysphoria 16.45 9.42 69 465805 6085 90156488
Thrombocytopenia 16.42 9.42 891 464983 207834 89954739
Hypokalaemia 16.40 9.42 531 465343 130585 90031988
Appendicitis 16.40 9.42 17 465857 10214 90152359
Sinus tachycardia 16.38 9.42 83 465791 28430 90134143
Amnestic disorder 16.36 9.42 15 465859 401 90162172
Blood lactate dehydrogenase increased 16.35 9.42 73 465801 25859 90136714
Illness anxiety disorder 16.28 9.42 10 465864 142 90162431
Substance abuser 16.25 9.42 11 465863 186 90162387
Drug dependence, antepartum 16.25 9.42 8 465866 71 90162502
Asthma 16.25 9.42 1451 464423 240709 89921864
Angioedema 16.25 9.42 235 465639 64641 90097932
Vaginal flatulence 16.22 9.42 116 465758 12522 90150051
Skin ulcer 16.21 9.42 354 465520 49721 90112852
Anosmia 16.20 9.42 16 465858 9832 90152741
Dissociation 16.20 9.42 73 465801 6642 90155931
Urinary incontinence 16.05 9.42 277 465597 37289 90125284
Face oedema 16.04 9.42 187 465687 23131 90139442
Homicidal ideation 15.98 9.42 31 465843 1749 90160824
Nerve compression 15.97 9.42 101 465773 10465 90152108
Hepatic failure 15.97 9.42 129 465745 39599 90122974
Dysphagia 15.96 9.42 718 465156 111560 90051013
Body mass index increased 15.86 9.42 28 465846 1469 90161104
Failure to thrive 15.86 9.42 12 465862 8399 90154174
Orthostatic hypotension 15.82 9.42 138 465736 41689 90120884
Urticaria chronic 15.73 9.42 20 465854 781 90161792
Live birth 15.72 9.42 299 465575 78808 90083765
Impaired healing 15.70 9.42 1015 464859 233184 89929389
Abortion spontaneous 15.66 9.42 190 465684 53866 90108707
Muscle spasticity 15.65 9.42 262 465612 35060 90127513
Psychomotor skills impaired 15.64 9.42 41 465833 2831 90159742
Papule 15.63 9.42 11 465863 7991 90154582
Mood swings 15.59 9.42 169 465705 20533 90142040
Head injury 15.58 9.42 236 465638 30952 90131621
Post-traumatic stress disorder 15.56 9.42 73 465801 6755 90155818
Cardiac failure 15.53 9.42 436 465438 109060 90053513
Chronic kidney disease 15.47 9.42 174 465700 50017 90112556
Joint range of motion decreased 15.45 9.42 849 465025 134794 90027779
Myoclonic epilepsy 15.42 9.42 29 465845 1598 90160975
Uveitis 15.42 9.42 37 465837 15866 90146707
Tobacco abuse 15.41 9.42 19 465855 719 90161854
Tricuspid valve incompetence 15.39 9.42 40 465834 16691 90145882
Joint dislocation 15.35 9.42 318 465556 44264 90118309
Urinary hesitation 15.34 9.42 37 465837 2426 90160147
Conversion disorder 15.30 9.42 34 465840 2112 90160461
Product storage error 15.30 9.42 53 465821 20188 90142385
Epidermal necrosis 15.28 9.42 36 465838 2325 90160248
Monocyte count abnormal 15.27 9.42 12 465862 258 90162315
Pupillary disorder 15.23 9.42 12 465862 259 90162314
Lung opacity 15.22 9.42 67 465807 6035 90156538
Visceral congestion 15.21 9.42 14 465860 376 90162197
Sleep deficit 15.19 9.42 22 465852 974 90161599
Musculoskeletal pain 15.07 9.42 1048 464826 170203 89992370
Screaming 15.07 9.42 48 465826 3702 90158871
Cerebrospinal fluid retention 15.02 9.42 8 465866 85 90162488
Negative symptoms in schizophrenia 15.01 9.42 9 465865 122 90162451
Laryngitis 14.94 9.42 354 465520 50399 90112174
Helicobacter infection 14.89 9.42 985 464889 225865 89936708
Sciatic nerve injury 14.88 9.42 19 465855 745 90161828
Eczema 14.87 9.42 187 465687 52683 90109890
Immunosuppressant drug level increased 14.81 9.42 3 465871 4677 90157896
Tooth injury 14.80 9.42 27 465847 1454 90161119
Disseminated cryptococcosis 14.78 9.42 19 465855 750 90161823
Carpal tunnel syndrome 14.76 9.42 188 465686 23740 90138833
Chest wall mass 14.74 9.42 17 465857 599 90161974
Vaginal discharge 14.71 9.42 159 465715 19305 90143268
Temperature intolerance 14.62 9.42 109 465765 11921 90150652
Apparent death 14.60 9.42 24 465850 1188 90161385
Nasopharyngitis 14.59 9.42 1851 464023 405253 89757320
Swollen joint count 14.53 9.42 85 465789 8568 90154005
Hereditary angioedema 14.52 9.42 16 465858 9349 90153224
Device leakage 14.49 9.42 18 465856 9973 90152600
Genital haemorrhage 14.47 9.42 14 465860 8688 90153885
Respiratory acidosis 14.45 9.42 81 465793 8038 90154535
Pulmonary haemorrhage 14.39 9.42 12 465862 8001 90154572
Peripheral venous disease 14.37 9.42 325 465549 83596 90078977
Abdominal pain 14.34 9.42 1798 464076 393923 89768650
Granulocyte count increased 14.12 9.42 27 465847 1507 90161066
Snoring 14.11 9.42 58 465816 5068 90157505
Hippocampal sclerosis 14.11 9.42 8 465866 97 90162476
Cyclic vomiting syndrome 14.10 9.42 10 465864 183 90162390
General physical health deterioration 14.04 9.42 2056 463818 353059 89809514
End stage renal disease 14.01 9.42 14 465860 8557 90154016
Vitamin D deficiency 14.01 9.42 145 465729 17411 90145162
Nasal mucosal disorder 13.90 9.42 30 465844 1827 90160746
Mental status changes postoperative 13.87 9.42 10 465864 188 90162385
Mitral valve incompetence 13.85 9.42 64 465810 22460 90140113
Asthma-chronic obstructive pulmonary disease overlap syndrome 13.82 9.42 4 465870 4895 90157678
Monocytosis 13.79 9.42 21 465853 973 90161600
Perfume sensitivity 13.78 9.42 21 465853 974 90161599
Sudden onset of sleep 13.75 9.42 16 465858 569 90162004
Musculoskeletal toxicity 13.73 9.42 16 465858 570 90162003
Forceps delivery 13.69 9.42 10 465864 192 90162381
Bradykinesia 13.63 9.42 70 465804 6718 90155855
Eye disorder 13.58 9.42 207 465667 27183 90135390
Language disorder 13.58 9.42 37 465837 2615 90159958
Hernia 13.55 9.42 122 465752 14109 90148464
Injection site irritation 13.52 9.42 7 465867 6008 90156565
Akathisia 13.50 9.42 101 465773 11058 90151515
Mite allergy 13.47 9.42 19 465855 821 90161752
Incoherent 13.45 9.42 56 465818 4921 90157652
Gingival bleeding 13.42 9.42 36 465838 14867 90147706
Cardiac output decreased 13.38 9.42 21 465853 999 90161574
Cardiomegaly 13.35 9.42 51 465823 18874 90143699
Nausea 13.35 9.42 5324 460550 1104992 89057581
Serum ferritin increased 13.32 9.42 11 465863 7370 90155203
Upper-airway cough syndrome 13.30 9.42 37 465837 15098 90147475
Renal injury 13.30 9.42 20 465854 10223 90152350
Congestive cardiomyopathy 13.22 9.42 11 465863 7343 90155230
Incontinence 13.22 9.42 116 465758 13319 90149254
Anti-cyclic citrullinated peptide antibody 13.22 9.42 205 465669 27016 90135557
Neurotoxicity 13.19 9.42 61 465813 21406 90141167
Metastases to bone 13.13 9.42 77 465797 25428 90137145
Colitis 13.10 9.42 267 465607 69675 90092898
Enuresis 13.09 9.42 43 465831 3371 90159202
Needle issue 13.06 9.42 33 465841 13901 90148672
Drug specific antibody present 13.03 9.42 6 465868 5508 90157065
Diverticulitis 13.02 9.42 159 465715 45028 90117545
Cerebral haemorrhage 13.01 9.42 114 465760 34408 90128165
Dehydration 12.98 9.42 843 465031 193604 89968969
Folliculitis 12.96 9.42 890 464984 203463 89959110
Drug ineffective for unapproved indication 12.96 9.42 441 465433 66203 90096370
Total cholesterol/HDL ratio abnormal 12.93 9.42 7 465867 77 90162496
Meralgia paraesthetica 12.93 9.42 15 465859 532 90162041
Self-injurious ideation 12.87 9.42 41 465833 3162 90159411
Reversed hot-cold sensation 12.83 9.42 3 465871 0 90162573
Transient psychosis 12.83 9.42 6 465868 47 90162526
Epilepsy 12.79 9.42 323 465551 81883 90080690
General symptom 12.79 9.42 36 465838 14632 90147941
Pharyngeal inflammation 12.78 9.42 21 465853 1039 90161534
High risk sexual behaviour 12.75 9.42 4 465870 8 90162565
Anti-actin antibody positive 12.75 9.42 4 465870 8 90162565
Social anxiety disorder 12.74 9.42 16 465858 617 90161956
Rheumatoid factor increased 12.71 9.42 34 465840 2377 90160196
Rheumatoid nodule 12.68 9.42 159 465715 20007 90142566
Scan abnormal 12.66 9.42 16 465858 621 90161952
Accommodation disorder 12.65 9.42 13 465861 401 90162172
Adenovirus infection 12.63 9.42 4 465870 4618 90157955
Disturbance in social behaviour 12.62 9.42 3 465871 4185 90158388
Pruritus 12.58 9.42 2524 463350 539001 89623572
Alanine aminotransferase increased 12.57 9.42 489 465385 117849 90044724
Cold sweat 12.55 9.42 119 465755 13962 90148611
Neck injury 12.52 9.42 34 465840 2398 90160175
Hyperammonaemia 12.51 9.42 9 465865 6466 90156107
Self-destructive behaviour 12.51 9.42 14 465860 477 90162096
Glucose tolerance impaired 12.49 9.42 77 465797 7908 90154665
Naevus flammeus 12.47 9.42 8 465866 123 90162450
Agoraphobia 12.47 9.42 15 465859 553 90162020
Drug detoxification 12.45 9.42 12 465862 342 90162231
Hyperlactacidaemia 12.39 9.42 3 465871 4133 90158440
Ventricular hypokinesia 12.33 9.42 6 465868 5335 90157238
Pulmonary embolism 12.32 9.42 548 465326 130272 90032301
Holmes-Adie pupil 12.24 9.42 5 465869 27 90162546
Vertigo CNS origin 12.24 9.42 5 465869 27 90162546
Decreased immune responsiveness 12.23 9.42 82 465792 8666 90153907
Cardiac murmur 12.22 9.42 50 465824 18144 90144429
Tunnel vision 12.19 9.42 27 465847 1674 90160899
Aspartate aminotransferase 12.17 9.42 17 465857 728 90161845
Drug effective for unapproved indication 12.16 9.42 76 465798 7842 90154731
Congenital pneumonia 12.14 9.42 4 465870 10 90162563
Weight fluctuation 12.12 9.42 155 465719 19594 90142979
Concussion 12.10 9.42 98 465776 10993 90151580
Gastrointestinal inflammation 12.06 9.42 10 465864 6686 90155887
Treatment noncompliance 12.05 9.42 190 465684 51537 90111036
Congenital anomaly 12.04 9.42 9 465865 6338 90156235
Hormone receptor positive HER2 negative breast cancer 12.03 9.42 11 465863 293 90162280
Sensorimotor disorder 11.99 9.42 17 465857 738 90161835
Drug-induced liver injury 11.96 9.42 363 465511 89955 90072618
Hearing disability 11.94 9.42 5 465869 29 90162544
Dyslipidaemia 11.93 9.42 21 465853 10086 90152487
Exposure to toxic agent 11.93 9.42 14 465860 7953 90154620
Skin cancer 11.92 9.42 33 465841 13486 90149087
Rhinovirus infection 11.91 9.42 8 465866 5955 90156618
Streptococcal sepsis 11.87 9.42 43 465831 3541 90159032
Tender joint count 11.85 9.42 24 465850 1397 90161176
Upper airway obstruction 11.85 9.42 20 465854 1012 90161561
Pulmonary tuberculosis 11.83 9.42 5 465869 4829 90157744
Walking aid user 11.81 9.42 252 465622 35254 90127319
Syringe issue 11.80 9.42 3 465871 3999 90158574
Confusion postoperative 11.77 9.42 10 465864 241 90162332
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.76 9.42 3 465871 3990 90158583
Reflexes abnormal 11.75 9.42 17 465857 752 90161821
Drug reaction with eosinophilia and systemic symptoms 11.74 9.42 152 465722 42606 90119967
Musculoskeletal stiffness 11.74 9.42 1717 464157 294815 89867758
Burnout syndrome 11.73 9.42 10 465864 242 90162331
Premature rupture of membranes 11.73 9.42 7 465867 5551 90157022
Juvenile idiopathic arthritis 11.69 9.42 3 465871 3974 90158599
Basal ganglion degeneration 11.69 9.42 12 465862 370 90162203
Nasal oedema 11.65 9.42 10 465864 6574 90155999
Peritonitis bacterial 11.65 9.42 6 465868 5165 90157408
Paraesthesia oral 11.62 9.42 228 465646 31431 90131142
Mastocytosis 11.61 9.42 19 465855 937 90161636
Allergy to chemicals 11.56 9.42 44 465830 3710 90158863
Vaccination site reaction 11.56 9.42 10 465864 247 90162326
Agitated depression 11.53 9.42 12 465862 376 90162197
Wrong dose 11.51 9.42 29 465845 1955 90160618
Eosinophil count increased 11.48 9.42 32 465842 13049 90149524
Neutropenic sepsis 11.45 9.42 51 465823 18079 90144494
Activated partial thromboplastin time prolonged 11.45 9.42 14 465860 7811 90154762
Pleural rub 11.41 9.42 6 465868 62 90162511
Rheumatic disorder 11.38 9.42 41 465833 3367 90159206
Electric shock sensation 11.34 9.42 25 465849 1545 90161028
Lymphocyte count abnormal 11.31 9.42 18 465856 867 90161706
Joint stiffness 11.29 9.42 500 465374 77542 90085031
Ear pruritus 11.25 9.42 11 465863 6792 90155781
Neurogenic bladder 11.24 9.42 43 465831 3635 90158938
Breast cancer female 11.24 9.42 39 465835 14847 90147726
Pregnancy with contraceptive device 11.23 9.42 6 465868 5060 90157513
Lumbar radiculopathy 11.18 9.42 34 465840 2557 90160016
Nail bed inflammation 11.16 9.42 27 465847 1774 90160799
Medical device site abscess 11.13 9.42 9 465865 202 90162371
Hepatic necrosis 11.13 9.42 10 465864 6428 90156145
Hypoxia 11.12 9.42 285 465589 72114 90090459
Diverticulum 11.11 9.42 29 465845 12084 90150489
Diffuse large B-cell lymphoma 11.11 9.42 17 465857 8628 90153945
Deafness 11.10 9.42 170 465704 22344 90140229
Disseminated intravascular coagulation 11.10 9.42 65 465809 21473 90141100
Spinal operation 11.07 9.42 90 465784 10106 90152467
Suicidal behaviour 11.06 9.42 36 465838 2808 90159765
Clumsiness 11.06 9.42 34 465840 2573 90160000
Hepatitis 10.99 9.42 278 465596 70461 90092112
Self esteem decreased 10.99 9.42 17 465857 799 90161774
Vitamin B12 increased 10.91 9.42 27 465847 1799 90160774
Phantom limb syndrome 10.91 9.42 9 465865 208 90162365
Depression suicidal 10.90 9.42 29 465845 2020 90160553
Intentional underdose 10.90 9.42 29 465845 2020 90160553
Anal sphincter atony 10.90 9.42 11 465863 332 90162241
Hepatic enzyme 10.90 9.42 7 465867 5337 90157236
Medication error 10.89 9.42 536 465338 84116 90078457
Dyslexia 10.89 9.42 14 465860 553 90162020
Pyrexia 10.88 9.42 3128 462746 657357 89505216
Colour blindness 10.88 9.42 11 465863 333 90162240
Oxygen consumption increased 10.83 9.42 5 465869 4584 90157989
Drug level decreased 10.79 9.42 21 465853 9709 90152864
Venous valve ruptured 10.76 9.42 3 465871 3 90162570
Muscle relaxant drug level above therapeutic 10.76 9.42 3 465871 3 90162570
Myoglobin urine 10.75 9.42 4 465870 16 90162557
Polycystic ovaries 10.74 9.42 8 465866 5646 90156927
Cerebral ventricular rupture 10.73 9.42 9 465865 213 90162360
Arteriosclerosis 10.72 9.42 25 465849 10828 90151745
Polyneuropathy 10.71 9.42 149 465725 19192 90143381
Rebound psychosis 10.69 9.42 9 465865 214 90162359
Neuropathy peripheral 10.66 9.42 830 465044 136140 90026433
Diabetic ulcer 10.59 9.42 8 465866 162 90162411
Ligament pain 10.55 9.42 9 465865 218 90162355
Illness 10.54 9.42 519 465355 81450 90081123
Paraplegia 10.52 9.42 40 465834 3372 90159201
Central pain syndrome 10.52 9.42 15 465859 655 90161918
Infusion site pain 10.48 9.42 59 465815 19679 90142894
Atrial flutter 10.45 9.42 25 465849 10733 90151840
Constipation 10.44 9.42 1618 464256 278777 89883796
Rash vesicular 10.43 9.42 53 465821 18144 90144429
Hydronephrosis 10.40 9.42 31 465843 12371 90150202
Sinus bradycardia 10.38 9.42 133 465741 16819 90145754
Abdominal pain lower 10.36 9.42 102 465772 30075 90132498
Proctitis 10.33 9.42 122 465752 15137 90147436
Lupus nephritis 10.32 9.42 6 465868 4826 90157747
Iridocyclitis 10.31 9.42 3 465871 3658 90158915
Blood albumin abnormal 10.30 9.42 20 465854 1129 90161444
Gastrooesophageal reflux disease 10.29 9.42 726 465148 165611 89996962
Deafness neurosensory 10.27 9.42 12 465862 6829 90155744
Status epilepticus 10.25 9.42 56 465818 18818 90143755
Back disorder 10.24 9.42 187 465687 25444 90137129
Cholecystitis chronic 10.23 9.42 22 465852 9804 90152769
Polyarthritis 10.21 9.42 54 465820 18296 90144277
Metabolic myopathy 10.21 9.42 7 465867 121 90162452
Thyroiditis 10.21 9.42 3 465871 3634 90158939
Thyroid hormones decreased 10.19 9.42 15 465859 674 90161899
Maternal drugs affecting foetus 10.18 9.42 7 465867 5148 90157425
Hot flush 10.18 9.42 388 465486 59100 90103473
Erythema multiforme 10.18 9.42 102 465772 12144 90150429
Overlap syndrome 10.14 9.42 77 465797 8471 90154102
Foreign body 10.09 9.42 32 465842 2462 90160111
Head titubation 10.09 9.42 21 465853 1247 90161326
Drug level below therapeutic 10.09 9.42 9 465865 5805 90156768
Blood immunoglobulin M increased 10.08 9.42 22 465852 1350 90161223
Methaemoglobinaemia 10.08 9.42 4 465870 4011 90158562
Tuberculosis 10.08 9.42 32 465842 12517 90150056
Radial nerve palsy 10.07 9.42 14 465860 597 90161976
Tumour marker increased 10.06 9.42 9 465865 5798 90156775
Major depression 10.06 9.42 87 465787 9948 90152625
Respiratory tract infection 10.05 9.42 229 465645 58849 90103724
Meningitis aseptic 10.04 9.42 12 465862 6761 90155812
Pleural fibrosis 10.03 9.42 3 465871 3593 90158980
Graft versus host disease in gastrointestinal tract 10.02 9.42 5 465869 4383 90158190
Crush syndrome 9.99 9.42 10 465864 299 90162274
X-ray abnormal 9.98 9.42 305 465569 45119 90117454
Subacute cutaneous lupus erythematosus 9.97 9.42 3 465871 3579 90158994
Decreased interest 9.96 9.42 47 465827 4360 90158213
Neuromyelitis optica spectrum disorder 9.95 9.42 23 465851 1467 90161106
Intervertebral disc degeneration 9.94 9.42 134 465740 17140 90145433
Breast cancer stage II 9.93 9.42 125 465749 35209 90127364
Blood immunoglobulin A increased 9.92 9.42 21 465853 1262 90161311
Calcification metastatic 9.91 9.42 8 465866 179 90162394
Cerebrospinal fluid reservoir placement 9.91 9.42 3 465871 5 90162568
Urea renal clearance decreased 9.88 9.42 4 465870 21 90162552
Peritonitis 9.88 9.42 60 465814 19645 90142928
Gastric bypass 9.87 9.42 28 465846 2026 90160547
Pneumonia fungal 9.85 9.42 13 465861 7018 90155555
Electric shock 9.81 9.42 25 465849 1697 90160876
Anaesthesia 9.77 9.42 12 465862 452 90162121
Cystic fibrosis 9.77 9.42 4 465870 3937 90158636
Mandibular mass 9.76 9.42 8 465866 183 90162390
Potentiating drug interaction 9.75 9.42 56 465818 5606 90156967
Drug intolerance 9.73 9.42 2093 463781 445498 89717075
Lymphadenopathy 9.72 9.42 171 465703 45604 90116969
Type IV hypersensitivity reaction 9.71 9.42 4 465870 3922 90158651
Anal abscess 9.71 9.42 9 465865 5699 90156874
Confabulation 9.69 9.42 10 465864 310 90162263
Dermatitis acneiform 9.69 9.42 11 465863 6343 90156230
Injection site mass 9.69 9.42 70 465804 22020 90140553
Dissociative disorder 9.63 9.42 14 465860 622 90161951
Food craving 9.63 9.42 27 465847 1940 90160633
Accident 9.61 9.42 65 465809 6889 90155684
Electrolyte imbalance 9.59 9.42 77 465797 23668 90138905
Intrathecal pump insertion 9.56 9.42 3 465871 6 90162567
Schizoaffective disorder bipolar type 9.55 9.42 8 465866 189 90162384
Poisoning deliberate 9.53 9.42 128 465746 16358 90146215
Lymphoproliferative disorder 9.52 9.42 5 465869 4257 90158316
Alcohol interaction 9.51 9.42 25 465849 1729 90160844
Peripheral nerve lesion 9.51 9.42 12 465862 465 90162108
Muscle rigidity 9.51 9.42 114 465760 14195 90148378
Corrective lens user 9.50 9.42 9 465865 251 90162322
Aura 9.50 9.42 20 465854 1197 90161376
Blood immunoglobulin A decreased 9.49 9.42 25 465849 1731 90160842
Pulmonary fibrosis 9.48 9.42 658 465216 106845 90055728
Diabetic ketosis 9.46 9.42 13 465861 548 90162025
Hypogammaglobulinaemia 9.45 9.42 26 465848 10648 90151925
Sarcoidosis 9.45 9.42 26 465848 10647 90151926
Cardiac tamponade 9.44 9.42 9 465865 5623 90156950

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2018.58 10.73 2409 187734 102362 42328830
Drug use disorder 1593.85 10.73 822 189321 9511 42421681
Drug dependence 1391.68 10.73 1104 189039 27990 42403202
Somnolence 993.35 10.73 2040 188103 139065 42292127
Withdrawal syndrome 895.26 10.73 646 189497 14129 42417063
Substance use disorder 864.07 10.73 439 189704 4906 42426286
Miosis 665.76 10.73 521 189622 12925 42418267
Coma 649.25 10.73 984 189159 52570 42378622
Intentional product misuse 573.40 10.73 1007 189136 60893 42370299
Toxicity to various agents 496.02 10.73 2179 187964 226957 42204235
Altered state of consciousness 460.12 10.73 609 189534 28650 42402542
Overdose 434.21 10.73 1239 188904 104025 42327167
Substance abuse 414.95 10.73 333 189810 8572 42422620
Pain 340.39 10.73 2058 188085 242790 42188402
Depressed level of consciousness 274.49 10.73 639 189504 47331 42383861
Drug withdrawal syndrome 269.52 10.73 402 189741 21147 42410045
Mydriasis 266.01 10.73 257 189886 8513 42422679
Prescription drug used without a prescription 238.87 10.73 150 189993 2580 42428612
Intentional overdose 236.01 10.73 630 189513 50826 42380366
Confusional state 231.39 10.73 1407 188736 166190 42265002
Bradypnoea 212.61 10.73 168 189975 4225 42426967
Aggression 205.85 10.73 544 189599 43619 42387573
Burning sensation 191.95 10.73 340 189803 20673 42410519
Suicidal ideation 185.91 10.73 554 189589 47607 42383585
Feeling abnormal 175.65 10.73 696 189447 69090 42362102
Myoclonus 163.51 10.73 282 189861 16783 42414409
Poisoning 162.44 10.73 259 189884 14440 42416752
Diarrhoea 158.36 10.73 1307 188836 459542 41971650
Prescribed overdose 152.89 10.73 235 189908 12692 42418500
Dysarthria 148.99 10.73 453 189690 39354 42391838
Respiratory depression 146.87 10.73 285 189858 18583 42412609
Disturbance in attention 146.44 10.73 375 189768 29491 42401701
Agitation 144.93 10.73 620 189523 63694 42367498
Gait disturbance 137.10 10.73 826 189317 97174 42334018
Insomnia 136.83 10.73 950 189193 117303 42313889
Febrile neutropenia 129.82 10.73 411 189732 185292 42245900
Memory impairment 119.25 10.73 492 189651 49730 42381462
Death 113.98 10.73 1452 188691 469733 41961459
Euphoric mood 110.26 10.73 140 190003 6313 42424879
Fall 104.96 10.73 1547 188596 232973 42198219
Hyperaesthesia 104.66 10.73 131 190012 5821 42425371
Pyrexia 104.46 10.73 1190 188953 392852 42038340
Suicide attempt 104.28 10.73 445 189698 45655 42385537
Multiple organ dysfunction syndrome 104.18 10.73 170 189973 96865 42334327
Visceral congestion 103.79 10.73 60 190083 881 42430311
Anaemia 103.35 10.73 779 189364 279499 42151693
Pain in extremity 102.09 10.73 1074 189069 149530 42281662
Dependence 101.89 10.73 70 190073 1410 42429782
Myelosuppression 100.39 10.73 28 190115 40433 42390759
Impaired driving ability 99.94 10.73 92 190051 2863 42428329
Restlessness 97.64 10.73 320 189823 28929 42402263
Therapeutic product effect incomplete 92.93 10.73 588 189555 70351 42360841
Pre-existing condition improved 92.06 10.73 88 190055 2875 42428317
Drug hypersensitivity 91.58 10.73 757 189386 98632 42332560
Dizziness 90.08 10.73 1587 188556 247667 42183525
Vision blurred 89.85 10.73 475 189668 53224 42377968
Neutropenia 89.72 10.73 522 189621 198909 42232283
Balance disorder 87.78 10.73 433 189710 47212 42383980
Disease progression 86.23 10.73 339 189804 143317 42287875
Ascites 84.38 10.73 77 190066 56601 42374591
Prescription form tampering 83.84 10.73 45 190098 567 42430625
Product dose omission issue 82.97 10.73 380 189763 153985 42277207
Inadequate analgesia 79.22 10.73 84 190059 3113 42428079
Cytomegalovirus infection 78.95 10.73 23 190120 32283 42398909
Fibromyalgia 78.38 10.73 92 190051 3821 42427371
Amnesia 75.87 10.73 289 189854 28148 42403044
Impaired work ability 74.58 10.73 166 189977 11925 42419267
Congenital hiatus hernia 74.08 10.73 113 190030 6061 42425131
Hypoaesthesia 73.31 10.73 558 189585 70905 42360287
Sopor 72.34 10.73 173 189970 13029 42418163
Thinking abnormal 72.11 10.73 121 190022 7040 42424152
Head discomfort 71.13 10.73 101 190042 5076 42426116
Bradykinesia 70.23 10.73 103 190040 5333 42425859
Off label use 69.32 10.73 2247 187896 636088 41795104
Speech disorder 68.88 10.73 285 189858 28836 42402356
Drug withdrawal maintenance therapy 68.43 10.73 27 190116 155 42431037
Sepsis 68.28 10.73 565 189578 198769 42232423
Cough 67.95 10.73 490 189653 177613 42253579
Accidental overdose 67.59 10.73 278 189865 28052 42403140
Road traffic accident 67.45 10.73 213 189930 18880 42412312
Victim of crime 66.17 10.73 37 190106 508 42430684
Loss of consciousness 64.58 10.73 663 189480 91691 42339501
Atrial fibrillation 64.55 10.73 362 189781 139231 42291961
Weight increased 64.38 10.73 751 189392 107232 42323960
Malignant melanoma in situ 63.83 10.73 70 190073 2697 42428495
Accidental poisoning 63.65 10.73 50 190093 1246 42429946
Cognitive disorder 62.54 10.73 310 189833 33862 42397330
Allodynia 62.08 10.73 46 190097 1048 42430144
Depression 61.79 10.73 764 189379 110599 42320593
Breath sounds abnormal 61.51 10.73 154 189989 11939 42419253
Sedation 60.49 10.73 283 189860 30192 42401000
Injection site pain 60.40 10.73 103 190040 57695 42373497
Bronchiectasis 59.11 10.73 196 189947 17823 42413369
Neuralgia 59.09 10.73 249 189894 25398 42405794
Tremor 58.61 10.73 676 189467 96253 42334939
Pneumonia 58.44 10.73 1436 188707 420713 42010479
Product prescribing error 58.22 10.73 251 189892 25861 42405331
Bradyphrenia 57.15 10.73 92 190051 5170 42426022
Rhinalgia 55.84 10.73 54 190089 1790 42429402
Disorientation 55.55 10.73 314 189829 36075 42395117
Reversible airways obstruction 54.94 10.73 34 190109 569 42430623
Anxiety 54.84 10.73 787 189356 117773 42313419
Dyspnoea 54.83 10.73 1530 188613 441091 41990101
Pancytopenia 54.60 10.73 305 189838 117438 42313754
Middle insomnia 54.58 10.73 113 190030 7720 42423472
Drug detoxification 54.12 10.73 29 190114 364 42430828
Gastrointestinal haemorrhage 54.01 10.73 238 189905 97488 42333704
C-reactive protein abnormal 53.62 10.73 124 190019 9137 42422055
Hospitalisation 52.92 10.73 163 189980 74167 42357025
Cardiac failure congestive 52.61 10.73 200 189943 85402 42345790
Neck pain 52.61 10.73 269 189874 29745 42401447
Substance use 52.50 10.73 51 190092 1700 42429492
Aspergillus infection 52.42 10.73 5 190138 15832 42415360
Feeling drunk 51.87 10.73 57 190086 2201 42428991
Hallucination, visual 51.51 10.73 208 189935 20812 42410380
Drug tolerance 50.94 10.73 68 190075 3222 42427970
Cerebral hypoperfusion 50.71 10.73 40 190103 1003 42430189
Rash 50.34 10.73 901 189242 276053 42155139
Intentional product use issue 49.88 10.73 515 189628 71318 42359874
Systemic infection 49.83 10.73 86 190057 5119 42426073
Therapy non-responder 49.65 10.73 102 190041 53257 42377935
Trigeminal neuralgia 49.51 10.73 47 190096 1522 42429670
Hypoacusis 49.01 10.73 189 189954 18513 42412679
Therapeutic response unexpected 48.79 10.73 136 190007 11245 42419947
Thrombocytopenia 48.54 10.73 579 189564 189700 42241492
Cytology abnormal 48.39 10.73 27 190116 369 42430823
Appendicolith 48.05 10.73 3 190140 13453 42417739
Lymphadenopathy 47.70 10.73 47 190096 33318 42397874
Affective disorder 47.56 10.73 91 190052 5869 42425323
Infection 47.36 10.73 299 189844 111769 42319423
Poisoning deliberate 47.35 10.73 125 190018 10009 42421183
Delirium 47.25 10.73 398 189745 52121 42379071
Paraesthesia 46.97 10.73 518 189625 72941 42358251
Respiratory failure 46.22 10.73 358 189785 127774 42303418
White blood cell count decreased 45.90 10.73 296 189847 110100 42321092
Substance abuser 45.33 10.73 23 190120 256 42430936
Herpes zoster 45.28 10.73 313 189830 38564 42392628
Terminal state 44.88 10.73 75 190068 4348 42426844
Acute kidney injury 44.35 10.73 1274 188869 366063 42065129
Nerve injury 44.18 10.73 70 190073 3880 42427312
Delusion of grandeur 43.47 10.73 49 190094 1947 42429245
Cardiac arrest 42.51 10.73 299 189844 109021 42322171
Hallucination, auditory 42.09 10.73 154 189989 14710 42416482
Dyskinesia 42.04 10.73 224 189919 25166 42406026
Epistaxis 41.80 10.73 155 189988 66671 42364521
Nervousness 41.57 10.73 144 189999 13388 42417804
Hypotension 41.33 10.73 856 189287 256775 42174417
Ejection fraction decreased 40.65 10.73 24 190119 22063 42409129
Cardiogenic shock 40.55 10.73 60 190083 35580 42395612
Undifferentiated connective tissue disease 40.53 10.73 16 190127 92 42431100
Graft versus host disease 40.44 10.73 5 190138 12920 42418272
Ventricular tachycardia 40.28 10.73 45 190098 30115 42401077
Ventricular fibrillation 40.17 10.73 45 190098 30078 42401114
Apparent death 39.14 10.73 64 190079 3644 42427548
Blood bilirubin increased 39.11 10.73 81 190062 42171 42389021
Septic shock 39.02 10.73 244 189899 91428 42339764
Photosensitivity reaction 38.88 10.73 135 190008 12567 42418625
Petit mal epilepsy 38.53 10.73 63 190080 3587 42427605
Cytomegalovirus infection reactivation 38.44 10.73 3 190140 11175 42420017
Drug diversion 37.87 10.73 33 190110 954 42430238
Abnormal behaviour 37.60 10.73 224 189919 26227 42404965
Vertigo 37.36 10.73 272 189871 34075 42397117
Visual impairment 37.35 10.73 324 189819 42789 42388403
Cannabinoid hyperemesis syndrome 37.18 10.73 9 190134 3 42431189
Blood creatinine increased 37.07 10.73 313 189830 109690 42321502
Urinary retention 36.96 10.73 318 189825 41896 42389296
Intentional self-injury 36.91 10.73 150 189993 15052 42416140
Pathogen resistance 36.90 10.73 4 190139 11446 42419746
Micturition urgency 36.89 10.73 127 190016 11771 42419421
Limb discomfort 36.76 10.73 133 190010 12634 42418558
Withdrawal arrhythmia 36.73 10.73 13 190130 52 42431140
Blood phosphorus increased 36.50 10.73 6 190137 12519 42418673
Diplopia 36.24 10.73 183 189960 20133 42411059
Pruritus 35.89 10.73 609 189534 188162 42243030
Drug resistance 35.80 10.73 61 190082 34187 42397005
Acute myocardial infarction 35.66 10.73 136 190007 58029 42373163
Sinusitis 35.61 10.73 101 190042 47191 42384001
Posterior reversible encephalopathy syndrome 35.50 10.73 7 190136 12814 42418378
Infusion related reaction 35.49 10.73 145 189998 60661 42370531
Dysaesthesia 35.30 10.73 50 190093 2507 42428685
Psychotic behaviour 34.81 10.73 31 190112 923 42430269
Seizure 34.71 10.73 742 189401 119819 42311373
Myoclonic epilepsy 34.60 10.73 40 190103 1634 42429558
Upper respiratory tract infection 34.07 10.73 87 190056 42086 42389106
Bacterial infection 33.64 10.73 45 190098 27834 42403358
Mucosal inflammation 33.23 10.73 111 190032 49263 42381929
Bronchopulmonary aspergillosis 33.17 10.73 23 190120 19406 42411786
Haematuria 33 10.73 139 190004 57660 42373532
Pleural effusion 32.95 10.73 276 189867 96890 42334302
Haemoptysis 32.31 10.73 102 190041 46065 42385127
Colour blindness acquired 32.23 10.73 14 190129 106 42431086
Sleep disorder due to a general medical condition 32.07 10.73 19 190124 17434 42413758
Appendicitis 31.88 10.73 27 190116 20586 42410606
Flushing 31.79 10.73 74 190069 36954 42394238
Hypopnoea 31.66 10.73 92 190051 7790 42423402
Intervertebral disc protrusion 31.59 10.73 115 190028 10957 42420235
Daydreaming 31.49 10.73 26 190117 697 42430495
Pneumonia aspiration 31.48 10.73 352 189791 49726 42381466
Nausea 31.36 10.73 1449 188694 395350 42035842
Congenital nystagmus 31.28 10.73 13 190130 87 42431105
Hallucination 31.21 10.73 393 189750 57114 42374078
Hypoxia 31.13 10.73 183 189960 69603 42361589
Therapy interrupted 31.05 10.73 32 190111 22218 42408974
Alcohol poisoning 30.99 10.73 89 190054 7485 42423707
Hyperphosphataemia 30.44 10.73 10 190133 12994 42418198
Platelet count decreased 30.41 10.73 435 189708 138146 42293046
Pulmonary alveolar haemorrhage 30.38 10.73 14 190129 14802 42416390
Arthropathy 30.27 10.73 231 189912 29366 42401826
Thrombotic microangiopathy 30.26 10.73 14 190129 14768 42416424
Bone marrow failure 30.16 10.73 64 190079 33029 42398163
Staphylococcal infection 30.14 10.73 78 190065 37565 42393627
Venoocclusive liver disease 29.87 10.73 5 190138 10297 42420895
Haemorrhage 29.65 10.73 154 189989 60409 42370783
Bladder dilatation 29.40 10.73 37 190106 1653 42429539
Clostridium difficile infection 28.98 10.73 35 190108 22624 42408568
Quality of life decreased 28.97 10.73 70 190073 5306 42425886
Prostate cancer 28.93 10.73 102 190041 44541 42386651
Depressed mood 28.86 10.73 191 189952 23193 42407999
Electric shock sensation 28.78 10.73 21 190122 467 42430725
Intestinal sepsis 28.60 10.73 25 190118 726 42430466
Hyponatraemia 28.49 10.73 302 189841 101160 42330032
BK virus infection 28.48 10.73 3 190140 8781 42422411
Hepatic failure 28.22 10.73 82 190061 38018 42393174
Joint injury 28.18 10.73 135 190008 14541 42416651
Aspartate aminotransferase increased 28.08 10.73 215 189928 76948 42354244
Erectile dysfunction 28.08 10.73 199 189944 24714 42406478
Cytomegalovirus viraemia 28.04 10.73 6 190137 10371 42420821
Behaviour disorder 28.01 10.73 82 190061 6972 42424220
White blood cell count increased 27.91 10.73 105 190038 44982 42386210
Device leakage 27.68 10.73 6 190137 10279 42420913
Interstitial lung disease 27.67 10.73 498 189645 77964 42353228
Lymphocyte count abnormal 27.62 10.73 41 190102 2146 42429046
Haemoglobin decreased 27.62 10.73 420 189723 132051 42299141
Gingival pain 27.51 10.73 92 190051 8402 42422790
Wrong technique in product usage process 27.24 10.73 98 190045 42537 42388655
Renal failure 27.20 10.73 464 189679 143262 42287930
Drug-induced liver injury 27.18 10.73 84 190059 38189 42393003
Catarrh 27.12 10.73 73 190070 5913 42425279
Tuberculosis 26.96 10.73 6 190137 10093 42421099
Enterococcal infection 26.90 10.73 10 190133 12029 42419163
Sleep disorder due to general medical condition, insomnia type 26.90 10.73 33 190110 1436 42429756
Hypothermia 26.90 10.73 119 190024 12396 42418796
Coordination abnormal 26.79 10.73 88 190055 7962 42423230
Phantom limb syndrome 26.43 10.73 16 190127 257 42430935
Mental impairment 26.38 10.73 117 190026 12200 42418992
Hypogammaglobulinaemia 26.37 10.73 10 190133 11881 42419311
Injection site reaction 26.33 10.73 19 190124 15702 42415490
Burns second degree 26.28 10.73 73 190070 6023 42425169
Irritability 26.27 10.73 215 189928 27913 42403279
Transplant rejection 26.11 10.73 14 190129 13574 42417618
Movement disorder 25.94 10.73 132 190011 14566 42416626
Wrong patient 25.81 10.73 22 190121 617 42430575
Migraine 25.79 10.73 198 189945 25216 42405976
Housebound 25.73 10.73 15 190128 224 42430968
Prerenal failure 25.69 10.73 42 190101 2391 42428801
Drug interaction 25.68 10.73 1446 188697 265553 42165639
Abdominal pain 25.67 10.73 650 189493 189821 42241371
Panic reaction 25.63 10.73 35 190108 1695 42429497
Haemodialysis 25.63 10.73 7 190136 10253 42420939
Myelopathy 25.40 10.73 46 190097 2845 42428347
Rhabdomyolysis 25.37 10.73 489 189654 77530 42353662
Narcolepsy 25.10 10.73 22 190121 641 42430551
International normalised ratio increased 25.00 10.73 120 190023 48048 42383144
Nephropathy toxic 24.90 10.73 23 190120 16815 42414377
Cytokine release syndrome 24.85 10.73 108 190035 44419 42386773
Depersonalisation/derealisation disorder 24.85 10.73 22 190121 650 42430542
Nicotinic acid deficiency 24.76 10.73 12 190131 120 42431072
Haematotoxicity 24.76 10.73 9 190134 10976 42420216
Phonophobia 24.65 10.73 16 190127 292 42430900
Mood altered 24.64 10.73 104 190039 10614 42420578
Post herpetic neuralgia 24.47 10.73 29 190114 1217 42429975
Pseudomonas infection 24.45 10.73 21 190122 15902 42415290
Oedematous pancreatitis 24.40 10.73 23 190120 738 42430454
Lymphoma 24.39 10.73 17 190126 14304 42416888
Tinnitus 24.29 10.73 216 189927 28722 42402470
Anaphylactic reaction 24.27 10.73 103 190040 42640 42388552
Myocardial infarction 24.22 10.73 398 189745 123611 42307581
Injection site swelling 24.15 10.73 24 190119 16949 42414243
Congenital hydrocephalus 24.07 10.73 13 190130 166 42431026
Candida infection 23.98 10.73 37 190106 21573 42409619
Nightmare 23.80 10.73 192 189951 24820 42406372
Tumour lysis syndrome 23.79 10.73 39 190104 22192 42409000
Parosmia 23.76 10.73 82 190061 7609 42423583
Pulmonary hypertension 23.71 10.73 43 190100 23526 42407666
Loss of personal independence in daily activities 23.53 10.73 332 189811 49484 42381708
Hyperpyrexia 23.42 10.73 50 190093 3490 42427702
Suicide threat 23.35 10.73 9 190134 48 42431144
Pulmonary thrombosis 23.22 10.73 86 190057 8262 42422930
Angioedema 23.12 10.73 104 190039 42373 42388819
Joint arthroplasty 23.03 10.73 25 190118 952 42430240
Injection site erythema 22.97 10.73 34 190109 20161 42411031
Alanine aminotransferase increased 22.89 10.73 268 189875 88138 42343054
Apathy 22.89 10.73 86 190057 8320 42422872
COVID-19 22.69 10.73 372 189771 115576 42315616
Ankylosing spondylitis 22.47 10.73 76 190067 6980 42424212
Carbon dioxide abnormal 22.01 10.73 15 190128 298 42430894
Nephrolithiasis 22.01 10.73 87 190056 36743 42394449
Steroid dependence 21.94 10.73 73 190070 6649 42424543
Acute respiratory failure 21.84 10.73 94 190049 38764 42392428
Epstein-Barr virus infection 21.84 10.73 8 190135 9710 42421482
Thermophobia 21.81 10.73 9 190134 59 42431133
Foetal exposure during pregnancy 21.67 10.73 123 190020 47188 42384004
Anger 21.65 10.73 115 190028 12903 42418289
Forced expiratory volume decreased 21.48 10.73 4 190139 7626 42423566
Vomiting 21.45 10.73 1065 189078 288658 42142534
Head circumference abnormal 21.34 10.73 8 190135 39 42431153
Hyperbilirubinaemia 21.34 10.73 37 190106 20598 42410594
Frustration tolerance decreased 21.27 10.73 46 190097 3240 42427952
Pneumocystis jirovecii pneumonia 21.07 10.73 51 190092 25130 42406062
Hypercholesterolaemia 21.02 10.73 113 190030 12736 42418456
Disseminated intravascular coagulation 20.92 10.73 50 190093 24744 42406448
Vestibular disorder 20.84 10.73 26 190117 1151 42430041
Blepharospasm 20.76 10.73 28 190115 1340 42429852
Cardiotoxicity 20.75 10.73 4 190139 7441 42423751
Sitting disability 20.73 10.73 13 190130 223 42430969
Myasthenia gravis 20.56 10.73 25 190118 16112 42415080
Respiratory symptom 20.53 10.73 12 190131 11094 42420098
Gait inability 20.51 10.73 173 189970 22660 42408532
Dry skin 20.38 10.73 129 190014 48209 42382983
Diverticulitis intestinal perforated 20.38 10.73 14 190129 282 42430910
Rhinorrhoea 20.36 10.73 73 190070 31721 42399471
Somatic symptom disorder 20.34 10.73 21 190122 754 42430438
Mental disorder 20.31 10.73 144 189999 17885 42413307
Systemic lupus erythematosus 20.30 10.73 89 190054 9235 42421957
Pneumothorax 20.25 10.73 47 190096 23496 42407696
Asphyxia 20.09 10.73 82 190061 8244 42422948
Multiple sclerosis 20.08 10.73 77 190066 7521 42423671
Viral infection 20.05 10.73 44 190099 22439 42408753
Binocular eye movement disorder 20.04 10.73 14 190129 290 42430902
Hiccups 20.01 10.73 15 190128 12156 42419036
Hyperarousal 19.98 10.73 8 190135 48 42431144
Persistent depressive disorder 19.79 10.73 17 190126 482 42430710
Colitis 19.79 10.73 124 190019 46448 42384744
Benign prostatic hyperplasia 19.71 10.73 161 189982 20891 42410301
Mucormycosis 19.57 10.73 4 190139 7139 42424053
Polyneuropathy in malignant disease 19.54 10.73 15 190128 361 42430831
Device related infection 19.51 10.73 38 190105 20241 42410951
Acute myeloid leukaemia 19.49 10.73 44 190099 22212 42408980
Ataxia 19.47 10.73 131 190012 15994 42415198
Neutrophil count decreased 19.35 10.73 185 189958 63230 42367962
Syringe issue 19.30 10.73 7 190136 8549 42422643
Labelled drug-drug interaction issue 19.28 10.73 31 190112 1740 42429452
Jaundice 19.24 10.73 84 190059 34505 42396687
Dissociative disorder 19.08 10.73 19 190124 653 42430539
Clumsiness 18.99 10.73 32 190111 1868 42429324
Renal impairment 18.91 10.73 362 189781 109866 42321326
Quadriparesis 18.90 10.73 36 190107 2314 42428878
Activated partial thromboplastin time prolonged 18.85 10.73 26 190117 15877 42415315
Toxic epidermal necrolysis 18.79 10.73 59 190084 26691 42404501
Hepatotoxicity 18.76 10.73 54 190089 25113 42406079
End stage renal disease 18.71 10.73 28 190115 16530 42414662
No adverse event 18.66 10.73 100 190043 38921 42392271
Red blood cell sedimentation rate abnormal 18.62 10.73 48 190095 3788 42427404
Dysstasia 18.57 10.73 117 190026 13969 42417223
Lung infiltration 18.54 10.73 21 190122 13968 42417224
Full blood count decreased 18.53 10.73 40 190103 20520 42410672
Benzodiazepine drug level decreased 18.53 10.73 7 190136 35 42431157
Blood glucose increased 18.47 10.73 225 189918 73474 42357718
Hypervolaemia 18.45 10.73 48 190095 23077 42408115
Sensory disturbance 18.42 10.73 71 190072 6952 42424240
Internal fixation of fracture 18.40 10.73 9 190134 92 42431100
Anorgasmia 18.38 10.73 24 190119 1113 42430079
Accessory spleen 18.36 10.73 10 190133 130 42431062
Hypovitaminosis 18.33 10.73 20 190123 766 42430426
Back pain 18.23 10.73 790 189353 140986 42290206
Amputation stump pain 18.17 10.73 5 190138 6 42431186
Neonatal epileptic seizure 18.15 10.73 8 190135 63 42431129
Cerebellar stroke 18.07 10.73 18 190125 619 42430573
Negative symptoms in schizophrenia 18.07 10.73 9 190134 96 42431096
Blood homocysteine increased 18.01 10.73 13 190130 284 42430908
Immunosuppressant drug level increased 18.00 10.73 6 190137 7725 42423467
Eosinophilic granulomatosis with polyangiitis 17.96 10.73 8 190135 8630 42422562
Premature baby 17.76 10.73 49 190094 23104 42408088
General physical health deterioration 17.75 10.73 835 189308 150411 42280781
Failure to thrive 17.68 10.73 10 190133 9412 42421780
Muscle twitching 17.54 10.73 101 190042 11679 42419513
Nodule 17.52 10.73 18 190125 12516 42418676
Substance dependence 17.49 10.73 18 190125 644 42430548
Injection site haemorrhage 17.39 10.73 16 190127 11720 42419472
Congestive hepatopathy 17.35 10.73 35 190108 2347 42428845
Dry mouth 17.34 10.73 262 189881 39617 42391575
Formication 17.33 10.73 32 190111 2009 42429183
Nerve degeneration 17.27 10.73 11 190132 194 42430998
Small intestinal obstruction 17.27 10.73 31 190112 17030 42414162
Gamma-glutamyltransferase increased 17.16 10.73 221 189922 32276 42398916
Melaena 17.07 10.73 102 190041 38644 42392548
Derealisation 16.95 10.73 20 190123 835 42430357
Social problem 16.81 10.73 24 190119 1212 42429980
Renal injury 16.75 10.73 18 190125 12262 42418930
Rebound effect 16.71 10.73 6 190137 7373 42423819
Anaemia of malignant disease 16.68 10.73 16 190127 525 42430667
Panic attack 16.65 10.73 95 190048 10950 42420242
Shock 16.64 10.73 70 190073 29051 42402141
Diabetic neuropathy 16.61 10.73 51 190092 4451 42426741
Kidney transplant rejection 16.60 10.73 9 190134 8674 42422518
Disease recurrence 16.55 10.73 72 190071 29606 42401586
Failure to anastomose 16.52 10.73 11 190132 210 42430982
Sciatica 16.51 10.73 71 190072 7306 42423886
Electrocardiogram QRS complex prolonged 16.50 10.73 3 190140 5820 42425372
Chest pain 16.49 10.73 485 189658 139045 42292147
Personality disorder 16.44 10.73 23 190120 1140 42430052
Haematocrit decreased 16.39 10.73 90 190053 34818 42396374
Dysphemia 16.37 10.73 30 190113 1872 42429320
Bladder cancer 16.35 10.73 32 190111 17015 42414177
Preterm premature rupture of membranes 16.34 10.73 8 190135 82 42431110
Alcohol interaction 16.31 10.73 32 190111 2103 42429089
Colon gangrene 16.02 10.73 5 190138 12 42431180
Psychotic disorder 16.01 10.73 200 189943 29008 42402184
Pseudoporphyria 15.97 10.73 15 190128 479 42430713
Drug abuser 15.94 10.73 43 190100 3488 42427704
Unresponsive to stimuli 15.93 10.73 212 189931 31191 42400001
Back disorder 15.81 10.73 71 190072 7443 42423749
Unevaluable event 15.78 10.73 89 190054 34199 42396993
Protein S decreased 15.77 10.73 8 190135 89 42431103
Spinal pain 15.74 10.73 66 190077 6716 42424476
Enteritis 15.73 10.73 15 190128 10801 42420391
Polyomavirus-associated nephropathy 15.68 10.73 3 190140 5612 42425580
Gastrointestinal disorder 15.59 10.73 133 190010 46520 42384672
Swollen tongue 15.58 10.73 154 189989 21077 42410115
Hypophosphataemia 15.57 10.73 45 190098 20900 42410292
Neuropathy peripheral 15.51 10.73 578 189565 101275 42329917
Weight decreased 15.45 10.73 764 189379 207184 42224008
Red blood cell sedimentation rate increased 15.38 10.73 86 190057 9838 42421354
Vertebral foraminal stenosis 15.37 10.73 17 190126 661 42430531
Nystagmus 15.36 10.73 56 190087 5340 42425852
Blood lactate dehydrogenase increased 15.33 10.73 62 190081 26019 42405173
Chills 15.20 10.73 312 189831 93754 42337438
Prostatic specific antigen increased 15.20 10.73 33 190110 16892 42414300
Sleep deficit 15.12 10.73 20 190123 939 42430253
Brain injury 15.12 10.73 71 190072 7584 42423608
Metabolic acidosis 15.10 10.73 153 189990 51705 42379487
Hypokalaemia 15.07 10.73 227 189916 71494 42359698
Bacteraemia 15.05 10.73 59 190084 24981 42406211
Generalised tonic-clonic seizure 15.05 10.73 182 189961 26197 42404995
Injection site pruritus 14.94 10.73 12 190131 9393 42421799
Fungal infection 14.93 10.73 42 190101 19680 42411512
Fatigue 14.90 10.73 1709 188434 433932 41997260
Dysgraphia 14.80 10.73 34 190109 2494 42428698
Coagulopathy 14.79 10.73 50 190093 22112 42409080
Schizophrenia 14.77 10.73 89 190054 10461 42420731
Dysphoria 14.77 10.73 36 190107 2744 42428448
Abdominal distension 14.74 10.73 228 189915 71507 42359685
Oropharyngeal pain 14.74 10.73 120 190023 42390 42388802
Erythema 14.71 10.73 371 189772 108422 42322770
Mood swings 14.70 10.73 78 190065 8748 42422444
Drug intolerance 14.66 10.73 466 189677 79958 42351234
Reading disorder 14.63 10.73 15 190128 534 42430658
Psychogenic seizure 14.55 10.73 14 190129 461 42430731
Pulseless electrical activity 14.39 10.73 10 190133 8427 42422765
Aplasia pure red cell 14.34 10.73 7 190136 7159 42424033
Haemolysis 14.30 10.73 13 190130 9576 42421616
Respiratory syncytial virus infection 14.29 10.73 7 190136 7145 42424047
Nervous system disorder 14.25 10.73 128 190015 17067 42414125
Reduced facial expression 14.25 10.73 25 190118 1508 42429684
Mitral valve incompetence 14.11 10.73 33 190110 16456 42414736
Herpes simplex 14.09 10.73 7 190136 7088 42424104
Pericardial effusion 14.01 10.73 75 190068 29200 42401992
Dermatitis atopic 13.99 10.73 21 190122 12383 42418809
Sexual activity increased 13.93 10.73 5 190138 21 42431171
Leukopenia 13.90 10.73 242 189901 74504 42356688
Product substitution 13.86 10.73 6 190137 45 42431147
Throat irritation 13.82 10.73 23 190120 13013 42418179
Dialysis 13.81 10.73 20 190123 11966 42419226
Hepatocellular injury 13.79 10.73 164 189979 23514 42407678
Limb injury 13.71 10.73 110 190033 14195 42416997
Influenza 13.68 10.73 195 189948 61980 42369212
Thrombosis 13.66 10.73 219 189924 68292 42362900
Testicular necrosis 13.65 10.73 4 190139 7 42431185
Anticholinergic syndrome 13.60 10.73 25 190118 1564 42429628
Chest injury 13.54 10.73 27 190116 1795 42429397
Body temperature increased 13.54 10.73 46 190097 20312 42410880
Coma scale abnormal 13.52 10.73 48 190095 4517 42426675
Campylobacter test positive 13.48 10.73 7 190136 82 42431110
Lymphopenia 13.48 10.73 50 190093 21513 42409679
Chest discomfort 13.48 10.73 201 189942 63415 42367777
Ecchymosis 13.47 10.73 9 190134 7743 42423449
Haemodynamic instability 13.46 10.73 22 190121 12535 42418657
Hepatic cirrhosis 13.45 10.73 44 190099 19658 42411534
Drug withdrawal headache 13.40 10.73 5 190138 24 42431168
Blood uric acid increased 13.40 10.73 31 190112 15516 42415676
Sleep disorder therapy 13.40 10.73 7 190136 6887 42424305
Accidental death 13.37 10.73 37 190106 3046 42428146
Myocardial depression 13.35 10.73 8 190135 126 42431066
Amputee 13.25 10.73 3 190140 0 42431192
Polyneuropathy idiopathic progressive 13.25 10.73 3 190140 0 42431192
Nerve root injury lumbar 13.25 10.73 3 190140 0 42431192
Iron deficiency 13.20 10.73 18 190125 11043 42420149
Sleep disorder 13.18 10.73 294 189849 47801 42383391
Blood calcium increased 13.16 10.73 11 190132 8443 42422749
Escherichia infection 13.14 10.73 19 190124 11377 42419815
Hypercapnia 13.09 10.73 53 190090 5308 42425884
Spinal stenosis 13.08 10.73 60 190083 6346 42424846
Feeling of body temperature change 13.08 10.73 25 190118 1611 42429581
Ventricular pre-excitation 13.08 10.73 5 190138 26 42431166
Product dispensing error 13.06 10.73 68 190075 7571 42423621
Visceral pain 13.05 10.73 7 190136 88 42431104
Aplastic anaemia 12.99 10.73 22 190121 12362 42418830
Klebsiella infection 12.96 10.73 19 190124 11313 42419879
Measles 12.92 10.73 11 190132 308 42430884
Motor dysfunction 12.90 10.73 71 190072 8075 42423117
Prostate tenderness 12.83 10.73 6 190137 55 42431137
Suicidal behaviour 12.83 10.73 24 190119 1522 42429670
Needle issue 12.81 10.73 12 190131 8715 42422477
Ventricular arrhythmia 12.77 10.73 6 190137 6273 42424919
Craniofacial fracture 12.73 10.73 12 190131 385 42430807
Drug screen positive 12.72 10.73 44 190099 4087 42427105
Hyperhidrosis 12.68 10.73 509 189634 90003 42341189
Proteinuria 12.67 10.73 56 190087 22927 42408265
Lower respiratory tract infection 12.66 10.73 120 190023 41086 42390106
Abdominal discomfort 12.64 10.73 248 189895 75007 42356185
Vasculitis 12.62 10.73 41 190102 18353 42412839
Homicidal ideation 12.58 10.73 34 190109 2760 42428432
Product storage error 12.43 10.73 19 190124 11121 42420071
Preternatural anus 12.40 10.73 7 190136 98 42431094
Staphylococcal bacteraemia 12.38 10.73 19 190124 11102 42420090
Oesophageal carcinoma 12.37 10.73 15 190128 9681 42421511
Eosinophil count increased 12.36 10.73 18 190125 10745 42420447
COVID-19 pneumonia 12.32 10.73 52 190091 21561 42409631
Screaming 12.31 10.73 27 190116 1920 42429272
Chondrocalcinosis 12.28 10.73 15 190128 650 42430542
Blood potassium decreased 12.27 10.73 48 190095 20336 42410856
Sensory loss 12.25 10.73 51 190092 5173 42426019
Eye pruritus 12.23 10.73 20 190123 11392 42419800
Skin toxicity 12.22 10.73 7 190136 6542 42424650
Hospice care 12.16 10.73 12 190131 8501 42422691
Nervous system neoplasm 12.14 10.73 8 190135 150 42431042
Libido decreased 12.13 10.73 50 190093 5048 42426144
Post laminectomy syndrome 12.11 10.73 9 190134 206 42430986
Panic disorder 12.09 10.73 21 190122 1256 42429936
Sexual dysfunction 12.06 10.73 61 190082 6714 42424478
Feeling cold 12.03 10.73 99 190044 12874 42418318
Haemorrhage intracranial 12.02 10.73 38 190105 17154 42414038
Age-related macular degeneration 12.01 10.73 11 190132 340 42430852
Impaired quality of life 11.99 10.73 106 190037 14071 42417121
Onychophagia 11.97 10.73 6 190137 65 42431127
Pseudolymphoma 11.92 10.73 15 190128 670 42430522
Myocardial ischaemia 11.90 10.73 40 190103 17722 42413470
Stupor 11.90 10.73 36 190107 3117 42428075
Oesophagitis 11.89 10.73 32 190111 15215 42415977
Blood folate decreased 11.83 10.73 17 190126 864 42430328
Application site hypersensitivity 11.81 10.73 7 190136 108 42431084
Congestive cardiomyopathy 11.79 10.73 13 190130 8751 42422441
SARS-CoV-2 test positive 11.77 10.73 70 190073 8190 42423002
Gout 11.76 10.73 75 190068 27980 42403212
Myositis 11.75 10.73 31 190112 14835 42416357
Serum ferritin increased 11.73 10.73 9 190134 7210 42423982
Slow response to stimuli 11.67 10.73 18 190125 975 42430217
Leukocytosis 11.66 10.73 81 190062 29627 42401565
Neurotoxicity 11.65 10.73 60 190083 23591 42407601
Coronary artery disease 11.64 10.73 169 189974 53551 42377641
Pulmonary tuberculosis 11.59 10.73 5 190138 5496 42425696
Onycholysis 11.50 10.73 18 190125 987 42430205
Astigmatism 11.47 10.73 21 190122 1310 42429882
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.46 10.73 23 190120 1536 42429656
Dissociative amnesia 11.43 10.73 6 190137 72 42431120
Visual field defect 11.42 10.73 48 190095 4890 42426302
Myopathy 11.41 10.73 28 190115 13733 42417459
Electrocardiogram abnormal 11.41 10.73 81 190062 10064 42421128
Abdominal rigidity 11.40 10.73 23 190120 1542 42429650
Electrocardiogram QT prolonged 11.40 10.73 148 189995 47797 42383395
Spinal fusion surgery 11.37 10.73 20 190123 1209 42429983
Spinal operation 11.34 10.73 43 190100 4177 42427015
Intervertebral disc operation 11.34 10.73 10 190133 294 42430898
Cerebral haemorrhage 11.33 10.73 115 190028 38851 42392341
Cytopenia 11.32 10.73 40 190103 17457 42413735
Torsade de pointes 11.28 10.73 13 190130 8581 42422611
Influenza virus test positive 11.27 10.73 8 190135 170 42431022
Constipation 11.24 10.73 855 189288 161436 42269756
Incorrect route of product administration 11.23 10.73 63 190080 24242 42406950
Body height decreased 11.21 10.73 42 190101 4058 42427134
Necrosis 11.19 10.73 8 190135 6643 42424549
Vibratory sense increased 11.18 10.73 3 190140 3 42431189
Tracheal pain 11.17 10.73 5 190138 41 42431151
Inappropriate schedule of product administration 11.16 10.73 334 189809 95568 42335624
Application site pain 11.16 10.73 29 190114 2300 42428892
Brain malformation 11.15 10.73 8 190135 173 42431019
Liver disorder 11.12 10.73 118 190025 39526 42391666
Wrong product administered 11.05 10.73 56 190087 6170 42425022
Dry eye 11.03 10.73 34 190109 15472 42415720
Methaemoglobinaemia 11.02 10.73 6 190137 5768 42425424
Chemical submission 10.95 10.73 6 190137 79 42431113
Hallucinations, mixed 10.94 10.73 37 190106 3398 42427794
Post procedural complication 10.93 10.73 25 190118 12565 42418627
Hyperlipidaemia 10.93 10.73 54 190089 21462 42409730
Aspiration 10.91 10.73 125 190018 17761 42413431
Venous oxygen saturation decreased 10.87 10.73 5 190138 44 42431148
Urinary hesitation 10.85 10.73 34 190109 3001 42428191
Anaphylactic shock 10.84 10.73 61 190082 23456 42407736
Injection site rash 10.81 10.73 6 190137 5706 42425486
Stent placement 10.80 10.73 50 190093 5310 42425882
Spinal shock 10.77 10.73 5 190138 45 42431147

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 2342.57 9.93 1638 558989 29742 109998930
Somnolence 1872.68 9.93 4442 556185 293007 109735665
Drug abuse 1777.04 9.93 3209 557418 174202 109854470
Drug dependence 1551.16 9.93 1572 559055 48448 109980224
Drug use disorder 1542.51 9.93 1025 559602 17049 110011623
Intentional product misuse 1109.00 9.93 2225 558402 130679 109897993
Substance use disorder 937.33 9.93 537 560090 6753 110021919
Coma 758.48 9.93 1777 558850 116092 109912580
Miosis 611.49 9.93 652 559975 21331 110007341
Pain 598.73 9.93 7427 553200 947528 109081144
Feeling abnormal 554.46 9.93 2094 558533 178617 109850055
Drug withdrawal syndrome 515.56 9.93 789 559838 37265 109991407
Altered state of consciousness 499.91 9.93 981 559646 56645 109972027
Substance abuse 471.44 9.93 437 560190 12026 110016646
Insomnia 379.10 9.93 3123 557504 357467 109671205
Overdose 362.57 9.93 2225 558402 231569 109797103
Depressed level of consciousness 358.36 9.93 1318 559309 110960 109917712
Sciatica 354.42 9.93 1153 559474 91246 109937426
Gait disturbance 350.62 9.93 2514 558113 275694 109752978
Confusional state 315.49 9.93 3698 556929 464982 109563690
Suicidal ideation 305.07 9.93 1109 559518 92828 109935844
Prescribed overdose 298.10 9.93 1050 559577 86531 109942141
Fall 283.44 9.93 4463 556164 599019 109429653
Therapeutic product effect incomplete 276.46 9.93 2013 558614 221792 109806880
Prescription drug used without a prescription 272.89 9.93 225 560402 5271 110023401
Myoclonus 264.93 9.93 544 560083 32454 109996218
Drug hypersensitivity 264.71 9.93 3488 557139 450602 109578070
Burning sensation 261.21 9.93 859 559768 68353 109960319
Disturbance in attention 256.36 9.93 794 559833 61201 109967471
Death 254.96 9.93 2290 558337 696579 109332093
Hypoacusis 253.42 9.93 555 560072 34636 109994036
Mydriasis 248.98 9.93 422 560205 21735 110006937
Sopor 248.16 9.93 563 560064 35983 109992689
Memory impairment 240.68 9.93 1767 558860 195177 109833495
Aggression 238.07 9.93 751 559876 58459 109970213
Bradypnoea 237.84 9.93 255 560372 8394 110020278
Toxicity to various agents 237.75 9.93 3586 557041 476969 109551703
Tremor 235.02 9.93 1793 558834 200439 109828233
Myelosuppression 234.74 9.93 92 560535 94248 109934424
Diarrhoea 232.54 9.93 4224 556403 1135281 108893391
Euphoric mood 230.07 9.93 253 560374 8574 110020098
Dysarthria 228.86 9.93 939 559688 83182 109945490
Pre-existing condition improved 228.03 9.93 219 560408 6307 110022365
Febrile neutropenia 225.96 9.93 834 559793 315933 109712739
Road traffic accident 221.17 9.93 1104 559523 106294 109922378
Respiratory depression 216.19 9.93 492 560135 31509 109997163
Impaired driving ability 215.50 9.93 210 560417 6160 110022512
Intentional overdose 210.32 9.93 1269 559358 131232 109897440
Neutropenia 207.88 9.93 1084 559543 373536 109655136
Anxiety 204.43 9.93 2659 557968 342419 109686253
Thinking abnormal 203.76 9.93 313 560314 14827 110013845
Dizziness 194.96 9.93 4773 555854 693420 109335252
Multiple organ dysfunction syndrome 191.61 9.93 295 560332 151415 109877257
Impaired work ability 184.97 9.93 412 560215 26007 110002665
Injection site pain 180.22 9.93 396 560231 177526 109851146
Pain in extremity 180.03 9.93 3468 557159 483650 109545022
Speech disorder 175.22 9.93 697 559930 60872 109967800
Agitation 172.00 9.93 1071 559556 111980 109916692
Hypoaesthesia 167.10 9.93 2375 558252 311848 109716824
Neuralgia 163.04 9.93 579 560048 47899 109980773
Disease progression 162.11 9.93 661 559966 243373 109785299
Restlessness 158.58 9.93 635 559992 55624 109973048
Loss of consciousness 155.73 9.93 1601 559026 194705 109833967
Malaise 153.36 9.93 4474 556153 667345 109361327
Weight increased 152.06 9.93 2979 557648 416665 109612007
Feeling drunk 150.96 9.93 162 560465 5338 110023334
Body height decreased 148.70 9.93 223 560404 10340 110018332
Balance disorder 145.31 9.93 1051 559576 115509 109913163
Therapeutic response unexpected 145.17 9.93 352 560275 23491 110005181
Disorientation 140.93 9.93 720 559907 69951 109958721
Gastrointestinal haemorrhage 140.71 9.93 403 560224 165115 109863557
Cytomegalovirus infection 140.63 9.93 50 560577 54394 109974278
Suicide attempt 139.26 9.93 950 559677 102444 109926228
Maternal exposure during pregnancy 138.81 9.93 742 559885 254141 109774531
Hyperaesthesia 135.38 9.93 257 560370 14470 110014202
Dependence 133.99 9.93 111 560516 2618 110026054
Amnesia 133.45 9.93 954 559673 104454 109924218
Injection site reaction 131.96 9.93 154 560473 88916 109939756
Coordination abnormal 131.31 9.93 351 560276 24877 110003795
Anaemia 128.46 9.93 1975 558652 545111 109483561
White blood cell count decreased 127.02 9.93 664 559963 228726 109799946
Exposure during pregnancy 123.81 9.93 434 560193 166990 109861682
Poisoning 122.39 9.93 375 560252 28730 109999942
Pemphigus 121.11 9.93 617 560010 213953 109814719
Product quality issue 119.59 9.93 129 560498 77170 109951502
Vision blurred 119.39 9.93 1087 559540 127935 109900737
Pancytopenia 118.73 9.93 602 560025 209011 109819661
Dyspnoea 118.34 9.93 4504 556123 1102368 108926304
Personality disorder 117.98 9.93 224 560403 12613 110016059
Sepsis 116.73 9.93 1078 559549 326268 109702404
Ascites 115.70 9.93 182 560445 92626 109936046
Premature delivery 115.19 9.93 11 560616 30621 109998051
Device expulsion 113.79 9.93 12 560615 30879 109997793
Injection site erythema 112.43 9.93 190 560437 93986 109934686
Product dispensing error 111.18 9.93 252 560375 16093 110012579
Injection site swelling 109.80 9.93 91 560536 61699 109966973
Hallucination, visual 109.20 9.93 444 560183 39161 109989511
Dyskinesia 107.41 9.93 531 560096 50915 109977757
Pericarditis 107.38 9.93 660 559967 218454 109810218
Vertigo 106.95 9.93 781 559846 86089 109942583
Atrial fibrillation 106.76 9.93 703 559924 228939 109799733
Irritability 105.96 9.93 502 560125 47307 109981365
Movement disorder 105.09 9.93 414 560213 35990 109992682
Product prescribing error 104.47 9.93 526 560101 50805 109977867
Septic shock 103.13 9.93 429 560198 157099 109871573
Mucosal inflammation 102.34 9.93 208 560419 95933 109932739
Rheumatoid arthritis 102.13 9.93 2108 558519 297505 109731167
Anti-cyclic citrullinated peptide antibody positive 101.17 9.93 526 560101 181458 109847214
Cardiac failure congestive 100.24 9.93 409 560218 150591 109878081
Allodynia 98.69 9.93 83 560544 2000 110026672
Platelet count decreased 98.48 9.93 723 559904 229720 109798952
Onychomycosis 98.47 9.93 36 560591 38495 109990177
Lower limb fracture 98.31 9.93 687 559940 74661 109954011
Pneumonia aspiration 98.10 9.93 727 559900 80506 109948166
Abdominal discomfort 97.14 9.93 1408 559219 392450 109636222
Rash 96.79 9.93 3300 557327 817664 109211008
Onychomadesis 96.04 9.93 56 560571 45607 109983065
Deep vein thrombosis postoperative 94.13 9.93 568 560059 58723 109969949
Hypotension 93.86 9.93 1983 558644 521866 109506806
Nervousness 93.69 9.93 403 560224 36448 109992224
Visceral congestion 92.92 9.93 67 560560 1278 110027394
C-reactive protein 92.51 9.93 351 560276 29980 109998692
Sensory loss 91.66 9.93 278 560349 21179 110007493
Off label use 91.42 9.93 6464 554163 1493721 108534951
Bradyphrenia 91.38 9.93 191 560436 11537 110017135
Cognitive disorder 91.24 9.93 757 559870 86754 109941918
Visual impairment 91.20 9.93 1063 559564 133365 109895307
Haemoglobin decreased 90.86 9.93 814 559813 247913 109780759
Swollen joint count increased 89.53 9.93 728 559899 82933 109945739
Aspergillus infection 89.29 9.93 12 560615 25604 110003068
Hyperhidrosis 88.67 9.93 1388 559239 185910 109842762
Product dose omission issue 87.73 9.93 1127 559500 320655 109708017
Respiratory failure 87.56 9.93 685 559942 214647 109814025
Intervertebral disc protrusion 86.52 9.93 323 560304 27375 110001297
Neutrophil count decreased 86.42 9.93 318 560309 120623 109908049
Alopecia 85.78 9.93 1316 559311 363437 109665235
International normalised ratio fluctuation 84.66 9.93 104 560523 3976 110024696
Wrong technique in product usage process 83.90 9.93 200 560427 87148 109941524
Pulmonary hypertension 83.39 9.93 94 560533 55126 109973546
Cardiac arrest 83.25 9.93 619 560008 196134 109832538
Loss of personal independence in daily activities 82.91 9.93 1142 559485 148878 109879794
Autoimmune disorder 81.91 9.93 591 560036 64892 109963780
Delirium 81.74 9.93 1045 559582 133980 109894692
Bloody discharge 81.24 9.93 84 560543 2649 110026023
Finger deformity 81.12 9.93 33 560594 33059 109995613
International normalised ratio increased 80.73 9.93 202 560425 86570 109942102
Intentional product use issue 80.17 9.93 1731 558896 246175 109782497
Transplant rejection 79.95 9.93 14 560613 24553 110004119
Cataract 79.38 9.93 681 559946 78804 109949868
Motor dysfunction 79.08 9.93 288 560339 24118 110004554
Gangrene 78.71 9.93 221 560406 16120 110012552
Substance use 78.08 9.93 79 560548 2427 110026245
Acute myocardial infarction 77.96 9.93 195 560432 83582 109945090
Systemic infection 77.78 9.93 161 560466 9658 110019014
Nail disorder 77.68 9.93 108 560519 57827 109970845
Intentional self-injury 77.19 9.93 385 560242 37044 109991628
Crying 76.04 9.93 294 560333 25334 110003338
Pneumonia 76.03 9.93 3651 556976 873063 109155609
Bradykinesia 75.25 9.93 168 560459 10620 110018052
Epistaxis 74.62 9.93 373 560254 129999 109898673
Adjustment disorder 74.05 9.93 167 560460 10628 110018044
Pleural effusion 73.32 9.93 563 560064 177146 109851526
Blood bilirubin increased 72.93 9.93 174 560453 75798 109952874
Dysstasia 72.83 9.93 346 560281 32640 109996032
Carotid artery thrombosis 72.81 9.93 155 560472 9483 110019189
Nerve injury 72.68 9.93 165 560462 10548 110018124
Inadequate analgesia 72.64 9.93 108 560519 4969 110023703
Accidental overdose 72.62 9.93 481 560146 51353 109977319
Drug resistance 71.75 9.93 109 560518 56265 109972407
Cytomegalovirus infection reactivation 70.50 9.93 6 560621 18327 110010345
Ventricular tachycardia 70.34 9.93 90 560537 49919 109978753
Affect lability 70.02 9.93 231 560396 18406 110010266
Angioedema 69.71 9.93 260 560367 98240 109930432
Renal failure 69.21 9.93 774 559853 225800 109802872
Dysgraphia 68.63 9.93 101 560526 4604 110024068
Cough 68.60 9.93 1798 558829 459843 109568829
Apparent death 68.50 9.93 79 560548 2823 110025849
Neurologic neglect syndrome 68.48 9.93 148 560479 9150 110019522
Mental impairment 68.23 9.93 261 560366 22378 110006294
Accidental poisoning 67.81 9.93 73 560554 2414 110026258
Expired product administered 67.77 9.93 138 560489 8182 110020490
Cytokine release syndrome 67.50 9.93 161 560466 70145 109958527
Drug detoxification 66.85 9.93 40 560587 548 110028124
Lyme disease 66.37 9.93 95 560532 4221 110024451
Ventricular fibrillation 66.09 9.93 67 560560 41246 109987426
Acute kidney injury 65.83 9.93 2594 558033 632836 109395836
Affective disorder 65.30 9.93 163 560464 11078 110017594
Blepharospasm 65.16 9.93 111 560516 54740 109973932
Graft versus host disease 65.10 9.93 9 560618 18797 110009875
Hepatotoxicity 65.09 9.93 140 560487 63260 109965412
Arterial occlusive disease 65.08 9.93 198 560429 15110 110013562
Sedation 64.91 9.93 588 560039 69095 109959577
Hospitalisation 64.80 9.93 439 560188 142054 109886618
Cardiogenic shock 63.65 9.93 121 560506 57217 109971455
Blood creatinine increased 63.55 9.93 606 560021 182283 109846389
Congenital hiatus hernia 63.54 9.93 114 560513 6145 110022527
Muscle twitching 63.21 9.93 310 560317 29625 109999047
Bronchopulmonary aspergillosis 62.27 9.93 37 560590 29826 109998846
Multiple sclerosis 62.26 9.93 277 560350 25421 110003251
Therapy interrupted 61.81 9.93 98 560529 49724 109978948
Taste disorder 61.78 9.93 151 560476 65236 109963436
Dry mouth 61.41 9.93 1386 559241 198562 109830110
Ejection fraction decreased 61.28 9.93 70 560557 40810 109987862
Thrombotic microangiopathy 60.94 9.93 36 560591 29113 109999559
Prescription form tampering 60.69 9.93 36 560591 485 110028187
Haematocrit decreased 60.67 9.93 155 560472 65962 109962710
Depression 60.53 9.93 2069 558558 315266 109713406
Blood iron abnormal 59.34 9.93 54 560573 1450 110027222
Feeling of despair 59.00 9.93 84 560543 3714 110024958
Cytomegalovirus viraemia 58.08 9.93 10 560617 17754 110010918
Nephropathy toxic 57.36 9.93 34 560593 27444 110001228
Behaviour disorder 57.22 9.93 141 560486 9506 110019166
Hypervolaemia 57.01 9.93 102 560525 49358 109979314
Appendicitis 56.95 9.93 37 560590 28427 110000245
Abdominal distension 56.75 9.93 590 560037 174513 109854159
Appendicolith 56.69 9.93 4 560623 14251 110014421
Product label confusion 56.59 9.93 22 560605 22655 110006017
Aspartate aminotransferase increased 56.40 9.93 528 560099 159408 109869264
Dysaesthesia 56.28 9.93 114 560513 6733 110021939
Pseudomonas infection 56.01 9.93 36 560591 27817 110000855
Venoocclusive liver disease 55.78 9.93 6 560621 15201 110013471
Arthritis 55.71 9.93 1175 559452 166411 109862261
Urinary retention 55.06 9.93 568 560059 69115 109959557
Torsade de pointes 54.65 9.93 23 560604 22577 110006095
Abnormal behaviour 54.52 9.93 362 560265 38677 109989995
Clostridium difficile infection 54.44 9.93 114 560513 52015 109976657
Drug withdrawal maintenance therapy 54.20 9.93 23 560604 141 110028531
Posterior reversible encephalopathy syndrome 54.07 9.93 55 560572 33806 109994866
Myocardial infarction 53.71 9.93 669 559958 191414 109837258
Injection site haemorrhage 53.48 9.93 53 560574 32975 109995697
Pathogen resistance 53.47 9.93 12 560615 17660 110011012
Trigeminal neuralgia 53.07 9.93 86 560541 4266 110024406
Coronary artery disease 52.87 9.93 186 560441 71504 109957168
Eating disorder 52.45 9.93 301 560326 30557 109998115
Thrombocytopenia 52.28 9.93 1357 559270 347528 109681144
Acute myeloid leukaemia 52.15 9.93 70 560557 38040 109990632
Hypomagnesaemia 52.01 9.93 146 560481 60224 109968448
Fibromyalgia 51.94 9.93 1183 559444 169726 109858946
Poor quality sleep 51.80 9.93 280 560347 27797 110000875
Accidental exposure to product 51.69 9.93 110 560517 49898 109978774
Lymphadenopathy 51.64 9.93 159 560468 63676 109964996
Depressed mood 51.58 9.93 503 560124 60306 109968366
Pyrexia 51.30 9.93 3890 556737 894375 109134297
Hallucination 51.19 9.93 760 559867 100672 109928000
Nightmare 51.08 9.93 355 560272 38508 109990164
Aphasia 50.53 9.93 489 560138 58508 109970164
Epstein-Barr virus infection 50.50 9.93 16 560611 18722 110009950
Pneumocystis jirovecii pneumonia 50.28 9.93 87 560540 42648 109986024
Limb discomfort 50.10 9.93 367 560260 40487 109988185
Diplopia 49.48 9.93 373 560254 41521 109987151
Sensory disturbance 49.33 9.93 197 560430 17232 110011440
Device difficult to use 49.03 9.93 17 560610 18788 110009884
Middle insomnia 48.92 9.93 220 560407 20282 110008390
Injection site pruritus 48.72 9.93 118 560509 51140 109977532
Breath sounds abnormal 48.68 9.93 256 560371 25148 110003524
Herpes zoster 48.58 9.93 796 559831 107583 109921089
Coagulopathy 48.40 9.93 83 560544 40828 109987844
Drug-induced liver injury 48.30 9.93 383 560244 119684 109908988
Substance abuser 47.97 9.93 30 560597 447 110028225
Apathy 47.94 9.93 186 560441 16053 110012619
General physical health deterioration 47.86 9.93 2625 558002 422670 109606002
Haemorrhage 47.86 9.93 330 560297 106362 109922310
Bacterial infection 47.80 9.93 101 560526 45935 109982737
Sensitivity to weather change 47.69 9.93 135 560492 9893 110018779
COVID-19 47.60 9.93 915 559712 244145 109784527
Flushing 47.45 9.93 323 560304 104413 109924259
Neoplasm progression 47.36 9.93 168 560459 64427 109964245
Panic attack 47.05 9.93 279 560348 28661 110000011
Gait inability 46.57 9.93 960 559667 135416 109893256
Liver disorder 46.20 9.93 994 559633 141249 109887423
Malignant melanoma in situ 45.95 9.93 72 560555 3470 110025202
Oropharyngeal pain 45.82 9.93 451 560176 134825 109893847
Drug dose omission by device 45.68 9.93 9 560618 14507 110014165
Pericardial effusion 44.54 9.93 145 560482 57072 109971600
Acute respiratory failure 44.40 9.93 213 560414 75047 109953625
Panic reaction 44.21 9.93 89 560538 5233 110023439
Therapy cessation 43.64 9.93 102 560525 44755 109983917
Hypersomnia 43.38 9.93 267 560360 27794 110000878
Alanine aminotransferase increased 43.17 9.93 663 559964 183110 109845562
Infective pulmonary exacerbation of cystic fibrosis 42.79 9.93 11 560616 14760 110013912
Left ventricular dysfunction 42.48 9.93 34 560593 23459 110005213
Fungal infection 42.21 9.93 125 560502 50681 109977991
Dry skin 42.10 9.93 346 560281 107307 109921365
Pulmonary alveolar haemorrhage 41.97 9.93 25 560602 20125 110008547
Poisoning deliberate 41.63 9.93 252 560375 26079 110002593
Hypoxia 41.31 9.93 438 560189 129077 109899595
Prostate cancer 41.29 9.93 80 560547 37561 109991111
Adenovirus infection 41.20 9.93 4 560623 10990 110017682
Eye pruritus 41.10 9.93 64 560563 32711 109995961
Head discomfort 41.01 9.93 198 560429 18802 110009870
Spinal stenosis 40.71 9.93 198 560429 18858 110009814
Proteinuria 40.55 9.93 89 560538 39929 109988743
Blood phosphorus increased 40.53 9.93 16 560611 16324 110012348
Hepatic failure 40.28 9.93 195 560432 68544 109960128
Haematotoxicity 40.05 9.93 29 560598 21053 110007619
Enterococcal infection 40.04 9.93 27 560600 20339 110008333
Back injury 39.82 9.93 116 560511 47283 109981389
Cytopenia 39.52 9.93 57 560570 30059 109998613
Mucormycosis 39.48 9.93 4 560623 10624 110018048
Feeling of body temperature change 39.44 9.93 93 560534 6095 110022577
Back pain 39.42 9.93 2278 558349 368718 109659954
Melaena 38.60 9.93 198 560429 68559 109960113
Pulmonary arterial hypertension 38.60 9.93 66 560561 32502 109996170
Mental disorder 38.54 9.93 332 560295 38459 109990213
Synovitis 38.46 9.93 1076 559551 273016 109755656
Myelodysplastic syndrome 38.28 9.93 83 560544 37401 109991271
Lung infiltration 38.20 9.93 41 560586 24587 110004085
Leukocytosis 38.14 9.93 142 560485 53686 109974986
Diabetic neuropathy 38.07 9.93 99 560528 6900 110021772
Nasal polyps 37.91 9.93 10 560617 13190 110015482
Libido increased 37.75 9.93 55 560572 2484 110026188
Hypokalaemia 37.35 9.93 675 559952 181773 109846899
Synovial fluid analysis 36.89 9.93 56 560571 2625 110026047
Anger 36.74 9.93 192 560435 18815 110009857
Delusion of grandeur 36.61 9.93 51 560576 2209 110026463
Anaphylactic shock 36.51 9.93 136 560491 51410 109977262
Reduced facial expression 36.42 9.93 66 560561 3585 110025087
Temperature regulation disorder 36.32 9.93 145 560482 12681 110015991
Device leakage 36.21 9.93 18 560609 16030 110012642
Parkinsonism 36.14 9.93 214 560413 21973 110006699
Device related infection 35.98 9.93 93 560534 39426 109989246
Injection site bruising 35.82 9.93 136 560491 51127 109977545
Cytology abnormal 35.40 9.93 22 560605 324 110028348
Blood calcium decreased 35.28 9.93 81 560546 35764 109992908
Bezoar 35.12 9.93 69 560558 3985 110024687
Withdrawal arrhythmia 35.11 9.93 13 560614 52 110028620
Aplastic anaemia 34.96 9.93 43 560584 24265 110004407
Neurotoxicity 34.95 9.93 104 560523 42103 109986569
Back disorder 34.85 9.93 203 560424 20719 110007953
Photophobia 34.81 9.93 237 560390 25534 110003138
Electric shock sensation 34.73 9.93 46 560581 1898 110026774
Haemophagocytic lymphohistiocytosis 34.68 9.93 67 560560 31492 109997180
Body tinea 34.67 9.93 48 560579 2067 110026605
Kidney transplant rejection 34.58 9.93 9 560618 11978 110016694
Drug tolerance 34.48 9.93 171 560456 16414 110012258
Sickle cell anaemia with crisis 34.42 9.93 4 560623 9541 110019131
Spinal pain 34.40 9.93 185 560442 18330 110010342
Breakthrough pain 34.04 9.93 41 560586 1535 110027137
Sleep disorder 33.87 9.93 1279 559348 197365 109831307
Activated partial thromboplastin time prolonged 33.85 9.93 38 560589 22330 110006342
Full blood count decreased 33.68 9.93 70 560557 32029 109996643
Frustration tolerance decreased 33.50 9.93 109 560518 8622 110020050
Bedridden 33.50 9.93 146 560481 13279 110015393
Immunosuppressant drug level increased 33.45 9.93 9 560618 11715 110016957
Blood lactate dehydrogenase increased 33.38 9.93 114 560513 44220 109984452
Device breakage 33.31 9.93 14 560613 13755 110014917
Haematuria 33.27 9.93 265 560362 82740 109945932
Tenosynovitis stenosans 33.27 9.93 63 560564 3540 110025132
Victim of crime 33.24 9.93 38 560589 1345 110027327
Negative symptoms in schizophrenia 33.18 9.93 18 560609 202 110028470
Tuberculosis 33.06 9.93 25 560602 17749 110010923
End stage renal disease 33.03 9.93 36 560591 21437 110007235
Dysphemia 32.93 9.93 67 560560 3970 110024702
Formication 32.91 9.93 82 560545 5566 110023106
Bone marrow failure 32.81 9.93 166 560461 57682 109970990
Hypogammaglobulinaemia 32.75 9.93 32 560595 20044 110008628
Stomatitis 32.72 9.93 1082 559545 269160 109759512
Hiatus hernia 32.66 9.93 56 560571 27550 110001122
Bacteraemia 32.60 9.93 108 560519 42282 109986390
Therapeutic product effect decreased 32.53 9.93 966 559661 243350 109785322
Small intestinal obstruction 32.35 9.93 72 560555 32141 109996531
Device use error 32.30 9.93 4 560623 9085 110019587
Muscular weakness 32.29 9.93 1555 559072 246913 109781759
Aspiration 32.28 9.93 265 560362 30268 109998404
Daydreaming 32.28 9.93 35 560592 1167 110027505
Hand deformity 32.15 9.93 852 559775 217654 109811018
Glossodynia 32.05 9.93 868 559759 221136 109807536
Malignant neoplasm progression 32.02 9.93 658 559969 173909 109854763
Restless legs syndrome 31.80 9.93 224 560403 24402 110004270
Ataxia 31.67 9.93 261 560366 29847 109998825
Phantom limb syndrome 31.60 9.93 22 560605 396 110028276
Bronchiectasis 31.51 9.93 303 560324 36190 109992482
Hostility 31.15 9.93 52 560575 2644 110026028
Red blood cell sedimentation rate increased 31.08 9.93 564 560063 77738 109950934
Injection site rash 31.05 9.93 44 560583 23375 110005297
Tension 30.95 9.93 75 560552 5003 110023669
Multiple sclerosis relapse 30.89 9.93 390 560237 49850 109978822
Throat irritation 30.75 9.93 153 560474 53399 109975273
Granulocytopenia 30.65 9.93 13 560614 12702 110015970
Lower respiratory tract infection 30.47 9.93 969 559658 242137 109786535
Mood altered 30.33 9.93 199 560428 21176 110007496
Persistent genital arousal disorder 30.11 9.93 26 560601 650 110028022
Tumour lysis syndrome 29.99 9.93 70 560557 30731 109997941
Hypoalbuminaemia 29.72 9.93 64 560563 28910 109999762
Nervous system disorder 29.71 9.93 268 560359 31453 109997219
Orthostatic hypotension 29.67 9.93 205 560422 66044 109962628
Ankle fracture 29.65 9.93 187 560440 19632 110009040
Electrocardiogram QT prolonged 29.51 9.93 382 560245 108578 109920094
X-ray abnormal 29.30 9.93 309 560318 37808 109990864
Hemiplegia 29.29 9.93 207 560420 22575 110006097
Disseminated intravascular coagulation 29.19 9.93 109 560518 41177 109987495
Caesarean section 28.98 9.93 17 560610 13800 110014872
Clostridium difficile colitis 28.77 9.93 119 560508 43659 109985013
Right ventricular failure 28.61 9.93 55 560572 25899 110002773
Pneumothorax 28.46 9.93 88 560539 35197 109993475
Colitis 28.36 9.93 357 560270 101966 109926706
Nausea 28.25 9.93 5682 554945 1230008 108798664
Hospice care 28.13 9.93 14 560613 12459 110016213
Spinal disorder 28.09 9.93 126 560501 11602 110017070
Product preparation error 28.08 9.93 10 560617 10869 110017803
Bladder cancer 28.04 9.93 37 560590 20255 110008417
Device issue 27.95 9.93 86 560541 34449 109994223
Fracture 27.77 9.93 218 560409 24570 110004102
Mitral valve incompetence 27.69 9.93 82 560545 33247 109995425
Skin haemorrhage 27.62 9.93 218 560409 24609 110004063
Hepatic necrosis 27.59 9.93 8 560619 9914 110018758
Screaming 27.54 9.93 70 560557 4811 110023861
Burns second degree 27.41 9.93 94 560533 7639 110021033
Malnutrition 27.37 9.93 61 560566 27218 110001454
Nocardiosis 27.34 9.93 3 560624 7483 110021189
Metastases to liver 27.32 9.93 90 560537 35296 109993376
Hypophosphataemia 27.30 9.93 82 560545 33100 109995572
Abdominal pain 27.26 9.93 2234 558393 510755 109517917
Vasculitis 27.17 9.93 92 560535 35781 109992891
Unintentional medical device removal 27.12 9.93 6 560621 8917 110019755
Emotional disorder 27.05 9.93 157 560470 16003 110012669
Renal injury 27.02 9.93 33 560594 18680 110009992
Lymphocyte count abnormal 26.98 9.93 46 560581 2380 110026292
Rhinovirus infection 26.94 9.93 13 560614 11776 110016896
Radiculopathy 26.82 9.93 179 560448 19157 110009515
Bladder dilatation 26.80 9.93 46 560581 2393 110026279
Asthma 26.79 9.93 1538 559089 248753 109779919
Drug diversion 26.75 9.93 34 560593 1346 110027326
Catarrh 26.74 9.93 90 560537 7245 110021427
Failure to thrive 26.68 9.93 18 560609 13556 110015116
Skull fracture 26.59 9.93 42 560585 2038 110026634
Myopathy 26.56 9.93 54 560573 24906 110003766
Negative thoughts 26.45 9.93 37 560590 1609 110027063
Grip strength 26.42 9.93 104 560523 9037 110019635
Leukopenia 26.35 9.93 564 560063 148227 109880445
Injection site urticaria 26.32 9.93 29 560598 17186 110011486
Hallucination, auditory 26.26 9.93 226 560401 26171 110002501
Metabolic acidosis 26.17 9.93 352 560275 99392 109929280
Dissociative disorder 26.14 9.93 32 560595 1219 110027453
Heart rate increased 26.12 9.93 543 560084 143291 109885381
Renal impairment 26.11 9.93 741 559886 187704 109840968
Candida infection 25.97 9.93 140 560487 47869 109980803
Endophthalmitis 25.92 9.93 5 560622 8182 110020490
Pre-eclampsia 25.92 9.93 6 560621 8644 110020028
Eosinophilic granulomatosis with polyangiitis 25.64 9.93 11 560616 10675 110017997
Device dislocation 25.62 9.93 79 560548 31625 109997047
Heparin-induced thrombocytopenia 25.49 9.93 13 560614 11411 110017261
Sleep deficit 25.46 9.93 38 560589 1754 110026918
Reading disorder 25.46 9.93 31 560596 1174 110027498
Inappropriate schedule of product administration 25.43 9.93 812 559815 202825 109825847
Atrial flutter 25.38 9.93 53 560574 24209 110004463
Graft versus host disease in gastrointestinal tract 25.37 9.93 7 560620 8961 110019711
Mood swings 25.21 9.93 200 560427 22612 110006060
Housebound 25.20 9.93 20 560607 443 110028229
Multiple allergies 25.19 9.93 126 560501 12137 110016535
No adverse event 25.07 9.93 246 560381 73593 109955079
Staphylococcal infection 25.04 9.93 230 560397 69714 109958958
Chest discomfort 25.01 9.93 680 559947 173168 109855504
Anorgasmia 24.98 9.93 36 560591 1610 110027062
Persistent depressive disorder 24.93 9.93 34 560593 1443 110027229
Cerebral haemorrhage 24.86 9.93 210 560417 64758 109963914
Palmar-plantar erythrodysaesthesia syndrome 24.85 9.93 115 560512 40910 109987762
Psoriatic arthropathy 24.84 9.93 1228 559399 195533 109833139
Arthralgia 24.84 9.93 3519 557108 776113 109252559
Post herpetic neuralgia 24.84 9.93 53 560574 3248 110025424
Dyslexia 24.80 9.93 19 560608 399 110028273
Alcohol poisoning 24.77 9.93 101 560526 8919 110019753
Substance dependence 24.71 9.93 24 560603 701 110027971
Hyperammonaemia 24.67 9.93 20 560607 13712 110014960
Ventricular hypokinesia 24.67 9.93 13 560614 11201 110017471
Macular degeneration 24.55 9.93 191 560436 21468 110007204
Thirst decreased 24.54 9.93 18 560609 353 110028319
Hypokinesia 24.48 9.93 192 560435 21634 110007038
Systemic candida 24.36 9.93 10 560617 9964 110018708
Cannabinoid hyperemesis syndrome 24.35 9.93 11 560616 80 110028592
Muscle spasticity 24.34 9.93 284 560343 35631 109993041
Anaphylactic reaction 24.30 9.93 420 560207 113880 109914792
Pulmonary tuberculosis 24.28 9.93 8 560619 9131 110019541
Neurosis 24.26 9.93 22 560605 588 110028084
Serum ferritin increased 24.25 9.93 15 560612 11832 110016840
Systemic lupus erythematosus 24.20 9.93 1048 559579 253290 109775382
Syringe issue 24.17 9.93 9 560618 9516 110019156
Acute respiratory distress syndrome 24.12 9.93 164 560463 53034 109975638
Dermatitis atopic 24.11 9.93 59 560568 25482 110003190
Increased appetite 24.10 9.93 144 560483 14833 110013839
Granuloma 24.02 9.93 9 560618 9481 110019191
Skin toxicity 24.01 9.93 15 560612 11768 110016904
Sneezing 23.99 9.93 258 560369 31726 109996946
Limb injury 23.93 9.93 294 560333 37342 109991330
Haemodialysis 23.78 9.93 33 560594 17686 110010986
Undifferentiated connective tissue disease 23.78 9.93 15 560612 227 110028445
Defaecation disorder 23.39 9.93 25 560602 820 110027852
Creatinine renal clearance decreased 23.38 9.93 47 560580 21768 110006904
Cytomegalovirus chorioretinitis 23.33 9.93 4 560623 7124 110021548
Intervertebral disc disorder 23.15 9.93 71 560556 5441 110023231
Gastritis 23.15 9.93 168 560459 53531 109975141
Glaucoma 23.04 9.93 194 560433 22323 110006349
Pulmonary vasculitis 23.04 9.93 3 560624 6557 110022115
Shock 22.93 9.93 168 560459 53420 109975252
Nasal congestion 22.93 9.93 355 560272 97927 109930745
Hepatitis B 22.89 9.93 10 560617 9602 110019070
Terminal state 22.88 9.93 72 560555 5595 110023077
Hyperarousal 22.87 9.93 9 560618 44 110028628
Premature labour 22.72 9.93 9 560618 9163 110019509
Chest pain 22.67 9.93 1622 559005 374753 109653919
Tricuspid valve incompetence 22.65 9.93 55 560572 23818 110004854
Complication associated with device 22.60 9.93 42 560585 20031 110008641
Sleep disorder due to general medical condition, insomnia type 22.49 9.93 698 559929 104945 109923727
Hypersensitivity 22.43 9.93 1753 558874 402245 109626427
Carcinoid tumour pulmonary 22.40 9.93 18 560609 406 110028266
Liver function test increased 22.33 9.93 315 560312 88233 109940439
Hyperbilirubinaemia 22.33 9.93 80 560547 30591 109998081
Illusion 22.25 9.93 38 560589 1969 110026703
Cholelithiasis 22.08 9.93 210 560417 63212 109965460
Respiratory symptom 21.96 9.93 26 560601 14919 110013753
Petit mal epilepsy 21.92 9.93 86 560541 7461 110021211
Lung consolidation 21.81 9.93 13 560614 10463 110018209
Injection site warmth 21.81 9.93 34 560593 17371 110011301
Rhinalgia 21.81 9.93 56 560571 3873 110024799
Adverse reaction 21.67 9.93 77 560550 29517 109999155
Cervix neoplasm 21.61 9.93 13 560614 180 110028492
Drug level decreased 21.60 9.93 38 560589 18510 110010162
Exposure to toxic agent 21.56 9.93 20 560607 12838 110015834
Parosmia 21.39 9.93 127 560500 13053 110015619
Anosmia 21.39 9.93 19 560608 12453 110016219
Foaming at mouth 21.34 9.93 40 560587 2230 110026442
Dialysis 21.25 9.93 42 560585 19577 110009095
Deep vein thrombosis 21.22 9.93 543 560084 139344 109889328
Chronic kidney disease 21.21 9.93 266 560361 76025 109952647
Eosinophil count increased 21.20 9.93 47 560580 21011 110007661
Muscle spasms 21.16 9.93 1661 558966 276496 109752176
Urinary tract infection 21.16 9.93 1397 559230 324885 109703787
Device malfunction 21.14 9.93 63 560564 25495 110003177
Methaemoglobinaemia 21.11 9.93 10 560617 9158 110019514
Jaundice 21.11 9.93 195 560432 59041 109969631
Somnambulism 21.10 9.93 76 560551 6329 110022343
Second primary malignancy 21.06 9.93 37 560590 18031 110010641
Dyspnoea exertional 20.97 9.93 386 560241 103674 109924998
Logorrhoea 20.96 9.93 64 560563 4893 110023779
Sinus disorder 20.95 9.93 256 560371 32472 109996200
Hepatitis B reactivation 20.88 9.93 6 560621 7478 110021194
Arteriospasm coronary 20.84 9.93 10 560617 9090 110019582
Pneumonitis 20.84 9.93 268 560359 76263 109952409
Oesophagitis 20.84 9.93 75 560552 28640 110000032
Hyperprolactinaemia 20.81 9.93 77 560550 6498 110022174
Thermophobia 20.71 9.93 9 560618 59 110028613
Complications of transplanted kidney 20.70 9.93 6 560621 7436 110021236
Drug interaction 20.62 9.93 2865 557762 497318 109531354
Hypothermia 20.59 9.93 214 560413 26088 110002584
Central obesity 20.56 9.93 37 560590 1999 110026673
Dust allergy 20.47 9.93 3 560624 5998 110022674
Treatment noncompliance 20.47 9.93 254 560373 72736 109955936
Body temperature increased 20.42 9.93 178 560449 54535 109974137
Drug reaction with eosinophilia and systemic symptoms 20.37 9.93 293 560334 81802 109946870
Sinus congestion 20.26 9.93 240 560387 30219 109998453
Illness 20.26 9.93 553 560074 81618 109947054
Contraindicated product administered 20.23 9.93 1040 559587 247227 109781445
Dyslipidaemia 20.19 9.93 31 560596 15934 110012738
Wrong patient 20.18 9.93 31 560596 1468 110027204
Self-injurious ideation 20.17 9.93 58 560569 4288 110024384
Antinuclear antibody positive 20.12 9.93 96 560531 9072 110019600
Dysphoria 20.11 9.93 75 560552 6353 110022319
Myasthenia gravis 20.06 9.93 50 560577 21461 110007211
Soft tissue injury 20.04 9.93 39 560588 2237 110026435
Uterine perforation 19.99 9.93 5 560622 6835 110021837
Psychotic behaviour 19.94 9.93 30 560597 1395 110027277
Acute hepatic failure 19.92 9.93 106 560521 36362 109992310
Venoocclusive disease 19.85 9.93 4 560623 6346 110022326
Alcohol interaction 19.84 9.93 52 560575 3642 110025030
Uveitis 19.83 9.93 51 560576 21659 110007013
Deafness 19.82 9.93 215 560412 26494 110002178
Sensorimotor disorder 19.82 9.93 27 560600 1145 110027527
Cardiomyopathy 19.70 9.93 95 560532 33430 109995242
Feeling jittery 19.65 9.93 135 560492 14587 110014085
Anal abscess 19.63 9.93 18 560609 11620 110017052
Congestive cardiomyopathy 19.57 9.93 26 560601 14193 110014479
Myocarditis 19.56 9.93 82 560545 29973 109998699
Lymphoma 19.51 9.93 46 560581 20125 110008547
Needle issue 19.49 9.93 38 560589 17802 110010870
Escherichia infection 19.49 9.93 59 560568 23757 110004915
Body mass index increased 19.40 9.93 39 560588 2291 110026381
Asphyxia 19.36 9.93 131 560496 14084 110014588
Subarachnoid haemorrhage 19.36 9.93 81 560546 29621 109999051
Neutropenic sepsis 19.33 9.93 85 560542 30661 109998011
Pneumonia fungal 19.29 9.93 28 560599 14726 110013946
Drug tolerance decreased 19.21 9.93 219 560408 27321 110001351
Nephrolithiasis 19.11 9.93 229 560398 65983 109962689
Myofascial pain syndrome 19 9.93 41 560586 2532 110026140
Synovial disorder 18.96 9.93 45 560582 2962 110025710
Pulmonary embolism 18.92 9.93 891 559736 213583 109815089
Internal fixation of fracture 18.84 9.93 18 560609 515 110028157
Diverticulum 18.83 9.93 31 560596 15495 110013177
Dehydration 18.76 9.93 1193 559434 278318 109750354
Distractibility 18.75 9.93 23 560604 878 110027794
Cardiac failure 18.71 9.93 769 559858 186857 109841815
Hyperphosphataemia 18.68 9.93 34 560593 16347 110012325
Urinary hesitation 18.64 9.93 59 560568 4599 110024073
Fear of injection 18.64 9.93 11 560616 8900 110019772
Productive cough 18.61 9.93 439 560188 113866 109914806
Conjunctivitis allergic 18.53 9.93 6 560621 6925 110021747
Hydronephrosis 18.53 9.93 49 560578 20616 110008056
Nerve compression 18.51 9.93 108 560519 11029 110017643
Coronary artery bypass 18.49 9.93 4 560623 6038 110022634
Arteriosclerosis 18.43 9.93 64 560563 24703 110003969
Vaginal flatulence 18.43 9.93 115 560512 12029 110016643
Rheumatoid factor positive 18.41 9.93 830 559797 130810 109897862
Food allergy 18.41 9.93 168 560459 19780 110008892
Homicidal ideation 18.41 9.93 50 560577 3577 110025095
Anal fistula 18.38 9.93 10 560617 8463 110020209
Quality of life decreased 18.36 9.93 129 560498 14040 110014632
Local anaesthetic systemic toxicity 18.36 9.93 3 560624 5534 110023138
Juvenile idiopathic arthritis 18.33 9.93 4 560623 6003 110022669
Intestinal sepsis 18.31 9.93 24 560603 980 110027692
Drug specific antibody present 18.23 9.93 10 560617 8424 110020248
Vomiting 18.14 9.93 4215 556412 906460 109122212
Sternal fracture 18.13 9.93 47 560580 3269 110025403
Vascular access site infection 18.12 9.93 11 560616 155 110028517
Steroid dependence 18.09 9.93 88 560539 8381 110020291
Vascular access site thrombosis 18.07 9.93 10 560617 117 110028555
Viral infection 18.05 9.93 177 560450 52962 109975710
Gastrointestinal inflammation 18.02 9.93 13 560614 9456 110019216
Lymphoproliferative disorder 18.02 9.93 7 560620 7211 110021461
Condition aggravated 17.99 9.93 4096 556531 730740 109297932
Respiratory acidosis 17.99 9.93 126 560501 13700 110014972
Musculoskeletal pain 17.94 9.93 1116 559511 181907 109846765
Papule 17.91 9.93 15 560612 10118 110018554
Hyponatraemia 17.87 9.93 911 559716 216742 109811930
Myocardial ischaemia 17.87 9.93 72 560555 26612 110002060
Snoring 17.87 9.93 75 560552 6709 110021963
Paraesthesia 17.84 9.93 1631 558996 274890 109753782
Psychogenic seizure 17.84 9.93 38 560589 2326 110026346
Unevaluable event 17.80 9.93 203 560424 59024 109969648
Psychomotor skills impaired 17.80 9.93 77 560550 6981 110021691
Diffuse large B-cell lymphoma recurrent 17.66 9.93 5 560622 6294 110022378
Benzodiazepine drug level decreased 17.66 9.93 7 560620 35 110028637
Product storage error 17.66 9.93 54 560573 21674 110006998
Vaginal discharge 17.65 9.93 153 560474 17755 110010917
Joint injury 17.64 9.93 293 560334 39701 109988971
Skin ulcer 17.63 9.93 435 560192 63210 109965462
Brain malformation 17.61 9.93 8 560619 59 110028613
Scleritis 17.59 9.93 64 560563 5356 110023316
Victim of chemical submission 17.59 9.93 22 560605 857 110027815
Abnormal dreams 17.54 9.93 118 560509 12662 110016010
Narcolepsy 17.52 9.93 30 560597 1558 110027114
Blood culture positive 17.51 9.93 12 560615 8964 110019708
Sleep disorder therapy 17.44 9.93 8 560619 7463 110021209
Inhibitory drug interaction 17.42 9.93 60 560567 4887 110023785
Visual acuity reduced 17.39 9.93 244 560383 31929 109996743
Rash maculo-papular 17.34 9.93 268 560359 73954 109954718
Suicide threat 17.31 9.93 9 560618 92 110028580
Peroneal nerve palsy 17.27 9.93 79 560548 7335 110021337
Carpal tunnel syndrome 17.24 9.93 183 560444 22427 110006245
Forced expiratory volume decreased 17.23 9.93 25 560602 13151 110015521
Constipation 17.23 9.93 2069 558558 355717 109672955
Rheumatic fever 17.17 9.93 773 559854 121806 109906866
Squamous cell carcinoma 17.15 9.93 43 560584 18420 110010252
Hypercapnia 17.14 9.93 106 560521 11053 110017619
Peritonitis 17.14 9.93 96 560531 32511 109996161
Status epilepticus 17.11 9.93 92 560535 31479 109997193
Breast cancer stage I 17.10 9.93 8 560619 7379 110021293
Brain herniation 17.09 9.93 12 560615 8851 110019821
Prescribed underdose 17.04 9.93 442 560185 64732 109963940
Diabetes insipidus 17.02 9.93 6 560621 6564 110022108
Nerve degeneration 16.97 9.93 13 560614 273 110028399
Visual field defect 16.96 9.93 98 560529 9974 110018698
Nicotinic acid deficiency 16.86 9.93 12 560615 224 110028448
Herpes simplex 16.86 9.93 34 560593 15730 110012942
Eyelid injury 16.86 9.93 11 560616 177 110028495
Pneumonia viral 16.84 9.93 19 560608 11138 110017534
Monoplegia 16.82 9.93 59 560568 4850 110023822
Hypopnoea 16.79 9.93 107 560520 11273 110017399
Lupus vulgaris 16.75 9.93 253 560374 33630 109995042
Injection site mass 16.75 9.93 66 560561 24547 110004125
Colorectal cancer 16.72 9.93 13 560614 9101 110019571
Product dose omission in error 16.67 9.93 62 560565 23450 110005222
Tooth extraction 16.64 9.93 25 560602 12966 110015706
Hyperpyrexia 16.64 9.93 83 560544 7986 110020686
Sexual activity increased 16.61 9.93 6 560621 22 110028650
Infusion related reaction 16.60 9.93 1685 558942 379477 109649195
Disseminated tuberculosis 16.60 9.93 3 560624 5143 110023529
Cerebrospinal fluid retention 16.59 9.93 9 560618 101 110028571
Acute myeloid leukaemia recurrent 16.57 9.93 3 560624 5136 110023536
Pruritus 16.57 9.93 2642 557985 578918 109449754
Post cholecystectomy syndrome 16.53 9.93 21 560606 831 110027841
Haemorrhage intracranial 16.50 9.93 83 560544 28886 109999786
Rhinitis allergic 16.45 9.93 42 560585 17880 110010792
Hypothyroidism 16.44 9.93 265 560362 72634 109956038
Orthostatic tremor 16.40 9.93 6 560621 23 110028649
Amputation stump pain 16.35 9.93 7 560620 44 110028628
Neoplasm malignant 16.34 9.93 272 560355 36871 109991801
Throat tightness 16.32 9.93 101 560526 33388 109995284
Type I hypersensitivity 16.29 9.93 6 560621 6387 110022285
Potentiating drug interaction 16.28 9.93 108 560519 11535 110017137
Rheumatoid factor negative 16.28 9.93 26 560601 1274 110027398
Cerebral infarction 16.24 9.93 176 560451 51662 109977010
Seizure 16.20 9.93 1317 559310 219868 109808804
Blood glucose increased 16.14 9.93 530 560097 131966 109896706
Prostatic specific antigen increased 16.10 9.93 24 560603 12487 110016185
Tissue infiltration 16.10 9.93 23 560604 1020 110027652
Deafness neurosensory 16.08 9.93 15 560612 9604 110019068
Dissociation 16.07 9.93 95 560532 9747 110018925
Patient uncooperative 16.06 9.93 22 560605 938 110027734
Interstitial lung disease 16.04 9.93 862 559765 138472 109890200
Impaired quality of life 15.96 9.93 227 560400 29790 109998882
Streptococcal infection 15.94 9.93 19 560608 10871 110017801
Oesophageal carcinoma 15.94 9.93 21 560606 11503 110017169
Intentional underdose 15.88 9.93 38 560589 2514 110026158
Periarthritis 15.78 9.93 50 560577 3900 110024772
Tachypnoea 15.68 9.93 126 560501 39269 109989403
Haemolysis 15.67 9.93 35 560592 15604 110013068
Swollen joint count 15.66 9.93 86 560541 8588 110020084
Headache 15.65 9.93 4851 555776 877526 109151146
Quadriparesis 15.64 9.93 56 560571 4651 110024021
Suicidal behaviour 15.59 9.93 46 560581 3451 110025221
Pulmonary haemorrhage 15.54 9.93 38 560589 16418 110012254
Benign prostatic hyperplasia 15.54 9.93 151 560476 18083 110010589
Eye disorder 15.53 9.93 219 560408 28687 109999985
Blood urea increased 15.50 9.93 191 560436 54766 109973906
Human herpesvirus 6 infection 15.43 9.93 7 560620 6574 110022098
Illness anxiety disorder 15.42 9.93 12 560615 258 110028414
Drug level below therapeutic 15.41 9.93 22 560605 11651 110017021
Psychomotor hyperactivity 15.41 9.93 164 560463 20113 110008559
Head injury 15.40 9.93 305 560322 42712 109985960
Staphylococcal bacteraemia 15.40 9.93 39 560588 16649 110012023
Thyroiditis 15.40 9.93 7 560620 6566 110022106
Klebsiella infection 15.37 9.93 51 560576 19958 110008714
Perfume sensitivity 15.31 9.93 23 560604 1068 110027604
Gingival pain 15.28 9.93 134 560493 15602 110013070
Respiratory tract infection 15.27 9.93 263 560364 71354 109957318
Porphyria acute 15.27 9.93 154 560473 18626 110010046
Poor quality product administered 15.23 9.93 55 560572 4586 110024086
Paralysis 15.23 9.93 133 560494 15467 110013205
Device related sepsis 15.22 9.93 10 560617 7637 110021035
N-terminal prohormone brain natriuretic peptide increased 15.17 9.93 6 560621 6115 110022557
Cyclic vomiting syndrome 15.16 9.93 10 560617 164 110028508
Cystitis haemorrhagic 15.16 9.93 24 560603 12185 110016487
Libido decreased 15.16 9.93 65 560562 5870 110022802
COVID-19 pneumonia 15.16 9.93 118 560509 37025 109991647
Drug dependence, antepartum 15.12 9.93 8 560619 85 110028587
Infusion site reaction 15.05 9.93 43 560584 17639 110011033
Blood sodium decreased 15.05 9.93 123 560504 38196 109990476
Accident 14.96 9.93 101 560526 10851 110017821
Renal cancer 14.91 9.93 27 560600 13007 110015665
Haemoptysis 14.91 9.93 263 560364 71091 109957581
Meralgia paraesthetica 14.91 9.93 17 560610 600 110028072
Food craving 14.89 9.93 32 560595 1971 110026701
Meningitis cryptococcal 14.89 9.93 3 560624 4759 110023913
Cardiac failure acute 14.88 9.93 67 560560 24011 110004661
Graft versus host disease in skin 14.86 9.93 12 560615 8242 110020430
Hypernatraemia 14.72 9.93 44 560583 17789 110010883
Oliguria 14.72 9.93 47 560580 18610 110010062
Antisocial behaviour 14.68 9.93 20 560607 848 110027824
Enteritis 14.60 9.93 49 560578 19107 110009565
Intervertebral disc degeneration 14.56 9.93 148 560479 17937 110010735
Total lung capacity decreased 14.54 9.93 73 560554 7041 110021631
Somatic symptom disorder 14.51 9.93 42 560585 3117 110025555
Pseudolymphoma 14.51 9.93 24 560603 1211 110027461
Mycotic allergy 14.49 9.93 6 560621 5948 110022724
Sciatic nerve injury 14.46 9.93 19 560608 778 110027894
Sarcoidosis 14.44 9.93 26 560601 12553 110016119
Pleuritic pain 14.42 9.93 135 560492 16005 110012667
Hiccups 14.42 9.93 27 560600 12842 110015830
Post-traumatic neck syndrome 14.42 9.93 37 560590 2558 110026114
Hearing disability 14.38 9.93 6 560621 35 110028637
Age-related macular degeneration 14.36 9.93 21 560606 952 110027720
Intestinal perforation 14.35 9.93 56 560571 20888 110007784
Visceral pain 14.34 9.93 9 560618 135 110028537
Contrast media allergy 14.29 9.93 44 560583 3379 110025293
Heart rate decreased 14.27 9.93 315 560312 82441 109946231
Hepatic function abnormal 14.25 9.93 344 560283 88951 109939721
Haemorrhoids 14.24 9.93 114 560513 35558 109993114
Surgery 14.24 9.93 137 560490 41146 109987526
Intervertebral disc operation 14.20 9.93 22 560605 1050 110027622
Polyneuropathy in malignant disease 14.18 9.93 15 560612 486 110028186
Prostate tenderness 14.13 9.93 7 560620 64 110028608
Liver function test abnormal 14.13 9.93 255 560372 68695 109959977
Cardiomegaly 14.12 9.93 88 560539 29042 109999630
Normal newborn 14.09 9.93 60 560567 21836 110006836
Hyperglycaemia 14.08 9.93 326 560301 84764 109943908
Hypovitaminosis 14.07 9.93 26 560601 1434 110027238
Bronchial secretion retention 14.07 9.93 4 560623 5020 110023652
Sleep terror 14.05 9.93 8 560619 6602 110022070
Respiratory distress 14.03 9.93 255 560372 68619 109960053
Diffuse large B-cell lymphoma 14.03 9.93 38 560589 15860 110012812
Wrong patient received product 14.01 9.93 69 560558 6605 110022067
Prothrombin time prolonged 13.96 9.93 43 560584 17218 110011454
Major depression 13.94 9.93 97 560530 10524 110018148
Incorrect product administration duration 13.92 9.93 55 560572 20443 110008229
Drug therapy 13.89 9.93 10 560617 7281 110021391
Blood pressure inadequately controlled 13.86 9.93 11 560616 7622 110021050
Haemoperitoneum 13.83 9.93 5 560622 5383 110023289
Blood lactic acid increased 13.82 9.93 38 560589 15783 110012889
Urticaria 13.82 9.93 1410 559217 317447 109711225
Amnestic disorder 13.79 9.93 18 560609 732 110027940
High risk sexual behaviour 13.73 9.93 8 560619 104 110028568
Aplasia pure red cell 13.72 9.93 17 560610 9561 110019111
Pruritus genital 13.71 9.93 8 560619 6514 110022158
Hepatocellular injury 13.69 9.93 345 560282 50297 109978375
Paraplegia 13.66 9.93 65 560562 6135 110022537
Hyperkalaemia 13.66 9.93 556 560071 135240 109893432
Dysuria 13.64 9.93 401 560226 59830 109968842
Meningitis aseptic 13.63 9.93 18 560609 9852 110018820
Hypocalcaemia 13.63 9.93 241 560386 65125 109963547
Coronary artery stenosis 13.61 9.93 31 560596 13727 110014945
Transient psychosis 13.60 9.93 7 560620 70 110028602
CADASIL 13.60 9.93 6 560621 41 110028631
Enterococcal bacteraemia 13.56 9.93 3 560624 4458 110024214
Nasal oedema 13.53 9.93 9 560618 6830 110021842
Anhedonia 13.52 9.93 37 560590 15391 110013281
Blood urine present 13.51 9.93 70 560557 24175 110004497
Infection susceptibility increased 13.50 9.93 51 560576 4347 110024325
Aplasia 13.49 9.93 12 560615 7861 110020811
Medical device site abscess 13.47 9.93 10 560617 200 110028472
Atrial tachycardia 13.45 9.93 16 560611 9162 110019510
Oxygen consumption increased 13.40 9.93 6 560621 5679 110022993
Complication of device insertion 13.39 9.93 15 560612 8823 110019849
Electrocardiogram ST segment elevation 13.39 9.93 16 560611 9144 110019528
Pulseless electrical activity 13.37 9.93 42 560585 16715 110011957
Organising pneumonia 13.37 9.93 33 560594 14210 110014462
Priapism 13.32 9.93 62 560565 5799 110022873
Phonophobia 13.32 9.93 17 560610 676 110027996
Hepatitis 13.27 9.93 351 560276 89703 109938969
Reversible airways obstruction 13.24 9.93 35 560592 2464 110026208
Skin cancer 13.20 9.93 46 560581 17738 110010934
Allergy to chemicals 13.20 9.93 42 560585 3283 110025389
Atonic urinary bladder 13.17 9.93 9 560618 157 110028515
Hernia 13.13 9.93 154 560473 19346 110009326
Crepitations 13.09 9.93 97 560530 10738 110017934
Rheumatic disorder 13.04 9.93 44 560583 3547 110025125
Sudden onset of sleep 13.03 9.93 17 560610 691 110027981
Gamma-glutamyltransferase increased 13.03 9.93 405 560222 60904 109967768
Gingival bleeding 12.99 9.93 54 560573 19785 110008887
Enuresis 12.99 9.93 48 560579 4048 110024624
Gestational diabetes 12.98 9.93 11 560616 7378 110021294
Odynophagia 12.98 9.93 33 560594 14068 110014604
Ischaemic stroke 12.97 9.93 140 560487 41123 109987549
Total cholesterol/HDL ratio abnormal 12.95 9.93 7 560620 78 110028594
Haemothorax 12.93 9.93 10 560617 7021 110021651
Clostridial infection 12.87 9.93 8 560619 6294 110022378
Dementia 12.87 9.93 229 560398 31444 109997228
Blood arsenic increased 12.87 9.93 3 560624 0 110028672
Nerve root injury lumbar 12.87 9.93 3 560624 0 110028672
Reversed hot-cold sensation 12.87 9.93 3 560624 0 110028672
Amputee 12.87 9.93 3 560624 0 110028672
Blister 12.86 9.93 985 559642 226391 109802281
Polyneuropathy 12.85 9.93 231 560396 31781 109996891
Cystic fibrosis 12.82 9.93 4 560623 4727 110023945
C-reactive protein increased 12.81 9.93 941 559686 216978 109811694
Coronary arterial stent insertion 12.80 9.93 7 560620 5908 110022764
Peritonitis bacterial 12.80 9.93 21 560606 10512 110018160
Haemodynamic instability 12.80 9.93 66 560561 22822 110005850
Sinus tachycardia 12.79 9.93 154 560473 44339 109984333
Nasal mucosal disorder 12.77 9.93 29 560598 1854 110026818
Self esteem decreased 12.75 9.93 21 560606 1056 110027616
Laryngeal disorder 12.73 9.93 22 560605 1151 110027521
Exposure via skin contact 12.70 9.93 30 560597 13117 110015555
Large intestine polyp 12.70 9.93 37 560590 15080 110013592
Stillbirth 12.69 9.93 3 560624 4261 110024411
Procedural pain 12.68 9.93 252 560375 35313 109993359
Pneumonia cytomegaloviral 12.65 9.93 10 560617 6944 110021728
Carotid artery occlusion 12.65 9.93 18 560609 9547 110019125
Device deployment issue 12.64 9.93 3 560624 4250 110024422
Asterixis 12.64 9.93 40 560587 3118 110025554
Analgesic therapy 12.61 9.93 11 560616 7273 110021399
Post laminectomy syndrome 12.60 9.93 13 560614 409 110028263
Incoherent 12.59 9.93 79 560548 8279 110020393
Clumsiness 12.58 9.93 45 560582 3735 110024937
Myoclonic epilepsy 12.58 9.93 36 560591 2655 110026017
Respiratory rate increased 12.56 9.93 75 560552 25008 110003664
Fixed eruption 12.55 9.93 3 560624 4229 110024443
Spinal osteoarthritis 12.54 9.93 157 560470 20026 110008646
Ageusia 12.54 9.93 54 560573 19591 110009081
Central pain syndrome 12.54 9.93 18 560609 802 110027870
Respiratory syncytial virus infection 12.50 9.93 35 560592 14449 110014223
Subdural haemorrhage 12.49 9.93 9 560618 6549 110022123
Upper-airway cough syndrome 12.47 9.93 40 560587 15817 110012855
Disease complication 12.46 9.93 7 560620 5820 110022852
Aortic stenosis 12.46 9.93 30 560597 13029 110015643
Ventricular pre-excitation 12.46 9.93 5 560622 26 110028646
Lupus nephritis 12.46 9.93 4 560623 4641 110024031
Holmes-Adie pupil 12.46 9.93 5 560622 26 110028646
Cholecystitis chronic 12.45 9.93 18 560609 9482 110019190
Upper gastrointestinal haemorrhage 12.35 9.93 179 560448 49917 109978755
Pneumonia pseudomonal 12.34 9.93 12 560615 7534 110021138
Chills 12.34 9.93 816 559811 189764 109838908
Foot fracture 12.34 9.93 190 560437 25356 110003316
Cardiotoxicity 12.31 9.93 44 560583 16837 110011835
Acute lymphocytic leukaemia recurrent 12.31 9.93 7 560620 5780 110022892
Iridocyclitis 12.30 9.93 6 560621 5402 110023270
Venous thrombosis 12.28 9.93 15 560612 8490 110020182
Cold sweat 12.28 9.93 168 560459 21863 110006809
Pituitary tumour benign 12.27 9.93 37 560590 2810 110025862
Tender joint count 12.25 9.93 24 560603 1383 110027289
Mobility decreased 12.23 9.93 1379 559248 236043 109792629
Pain in jaw 12.22 9.93 184 560443 50993 109977679
Palmoplantar keratoderma 12.22 9.93 6 560621 5381 110023291
Mental status changes 12.21 9.93 293 560334 75829 109952843
Failure to anastomose 12.21 9.93 10 560617 232 110028440
Diabetic foot 12.17 9.93 47 560580 4048 110024624
Vertigo CNS origin 12.16 9.93 5 560622 28 110028644
Enterocolitis 12.15 9.93 52 560575 18897 110009775
Cardiac hypertrophy 12.13 9.93 29 560598 1918 110026754
Blood immunoglobulin E increased 12.12 9.93 12 560615 7470 110021202
Peripheral venous disease 12.10 9.93 329 560298 83788 109944884
Vestibular disorder 12.10 9.93 35 560592 2597 110026075
Hormone receptor positive HER2 negative breast cancer 12.07 9.93 10 560617 236 110028436
Vaccination site reaction 12.03 9.93 10 560617 237 110028435
Depersonalisation/derealisation disorder 12.02 9.93 31 560596 2150 110026522
Escherichia sepsis 12.00 9.93 21 560606 10251 110018421
Weight fluctuation 11.99 9.93 168 560459 21977 110006695
Nystagmus 11.98 9.93 100 560527 11477 110017195
Thrombosis in device 11.98 9.93 6 560621 5321 110023351
Self-destructive behaviour 11.96 9.93 18 560609 837 110027835
Akathisia 11.90 9.93 136 560491 16977 110011695
Hepatic fibrosis 11.89 9.93 14 560613 8052 110020620
Micturition urgency 11.88 9.93 150 560477 19170 110009502
Splenomegaly 11.88 9.93 74 560553 24424 110004248
Liver abscess 11.87 9.93 13 560614 7726 110020946
Shock haemorrhagic 11.86 9.93 85 560542 27162 110001510
Peripheral coldness 11.86 9.93 145 560482 18395 110010277
Lactic acidosis 11.84 9.93 369 560258 92442 109936230
Reflexes abnormal 11.84 9.93 20 560607 1027 110027645
Rheumatoid nodule 11.82 9.93 156 560471 20140 110008532
Cytomegalovirus colitis 11.82 9.93 11 560616 7050 110021622
Faecal calprotectin increased 11.81 9.93 10 560617 6709 110021963
Granulocyte count increased 11.78 9.93 29 560598 1954 110026718
Stevens-Johnson syndrome 11.77 9.93 167 560460 46734 109981938
Medication error 11.76 9.93 650 559977 104716 109923956
Diffuse alveolar damage 11.75 9.93 3 560624 4044 110024628
Cardiac operation 11.71 9.93 8 560619 5987 110022685
Blood albumin decreased 11.68 9.93 87 560540 27565 110001107
Acne 11.66 9.93 111 560516 33409 109995263
Head titubation 11.64 9.93 23 560604 1334 110027338
Aspartate aminotransferase 11.61 9.93 19 560608 950 110027722
Decreased immune responsiveness 11.61 9.93 86 560541 9520 110019152
Concussion 11.59 9.93 99 560528 11439 110017233
Preternatural anus 11.57 9.93 7 560620 98 110028574
Blood homocysteine increased 11.53 9.93 13 560614 453 110028219
Hypoproteinaemia 11.53 9.93 8 560619 5937 110022735
Upper limb fracture 11.53 9.93 159 560468 20729 110007943
Wound 11.53 9.93 1027 559600 233410 109795262
Mycobacterial infection 11.50 9.93 4 560623 4413 110024259
Troponin increased 11.48 9.93 96 560531 29670 109999002
Photosensitivity reaction 11.48 9.93 188 560439 25401 110003271
Ecchymosis 11.47 9.93 47 560580 17291 110011381
Platelet count abnormal 11.47 9.93 9 560618 6273 110022399
Tonic clonic movements 11.46 9.93 37 560590 2915 110025757
Serum sickness 11.46 9.93 4 560623 4402 110024270
Unintended pregnancy 11.45 9.93 5 560622 4803 110023869
Eructation 11.38 9.93 35 560592 14022 110014650
Foetal death 11.38 9.93 128 560499 15917 110012755
Distributive shock 11.38 9.93 8 560619 5896 110022776
Orthostatic intolerance 11.36 9.93 30 560597 2111 110026561
Calcification metastatic 11.35 9.93 8 560619 147 110028525
Red blood cell count decreased 11.35 9.93 251 560376 65672 109963000
Varicose vein 11.34 9.93 67 560560 6873 110021799
Neuropathy peripheral 11.34 9.93 1056 559571 178221 109850451
Thrombosis 11.34 9.93 443 560184 108219 109920453
Psychomotor retardation 11.33 9.93 73 560554 7719 110020953
Abscess 11.33 9.93 87 560540 27382 110001290
Pneumatosis intestinalis 11.33 9.93 16 560611 8513 110020159
Splenic infarction 11.32 9.93 4 560623 4370 110024302
Tinea infection 11.32 9.93 24 560603 1464 110027208
Mental status changes postoperative 11.31 9.93 9 560618 200 110028472
Glucose tolerance impaired 11.29 9.93 87 560540 9750 110018922
Acute generalised exanthematous pustulosis 11.27 9.93 64 560563 21600 110007072
Sedation complication 11.24 9.93 57 560570 19798 110008874
Pleural rub 11.24 9.93 6 560621 65 110028607
Sitting disability 11.24 9.93 13 560614 466 110028206
Breast cancer stage III 11.24 9.93 310 560317 78807 109949865
Anaemia of malignant disease 11.23 9.93 19 560608 977 110027695
Hepatic lesion 11.22 9.93 16 560611 8477 110020195
Adactyly 11.21 9.93 4 560623 14 110028658
Atrial thrombosis 11.21 9.93 4 560623 4342 110024330
Liver transplant rejection 11.19 9.93 3 560624 3915 110024757
Autoimmune hepatitis 11.19 9.93 38 560589 14766 110013906
Protein S decreased 11.17 9.93 8 560619 151 110028521
Accessory spleen 11.16 9.93 9 560618 204 110028468
Stupor 11.16 9.93 76 560551 8189 110020483
Oedema 11.14 9.93 1222 559405 208754 109819918
Gout 11.12 9.93 125 560502 36441 109992231
Hanging 11.09 9.93 9 560618 206 110028466
Intestinal stenosis 11.08 9.93 5 560622 4710 110023962
Sputum culture positive 11.07 9.93 3 560624 3886 110024786
Pleural fibrosis 11.05 9.93 4 560623 4304 110024368
Pleural neoplasm 11.02 9.93 12 560615 402 110028270
Limb fracture 10.99 9.93 5 560622 37 110028635
Mastocytosis 10.91 9.93 17 560610 815 110027857
Oedema peripheral 10.90 9.93 1860 558767 326800 109701872
Abortion spontaneous 10.90 9.93 116 560511 34166 109994506
Chest injury 10.85 9.93 40 560587 3369 110025303
Systemic mycosis 10.81 9.93 3 560624 3826 110024846
Muscle relaxant drug level above therapeutic 10.81 9.93 3 560624 3 110028669
Iron deficiency anaemia 10.77 9.93 105 560522 31454 109997218
Fungaemia 10.77 9.93 9 560618 6077 110022595
Hypovolaemia 10.76 9.93 65 560562 21609 110007063
Hepatomegaly 10.74 9.93 64 560563 21350 110007322
Hypoventilation 10.73 9.93 74 560553 8007 110020665
Dermatitis acneiform 10.71 9.93 31 560596 12664 110016008
Abortion induced 10.70 9.93 15 560612 8004 110020668
Rhabdomyolysis 10.68 9.93 728 559899 119673 109908999
Diastolic dysfunction 10.68 9.93 30 560597 12374 110016298
Tooth loss 10.66 9.93 74 560553 8022 110020650
Lumbar radiculopathy 10.64 9.93 33 560594 2545 110026127
Toxic encephalopathy 10.62 9.93 121 560506 15093 110013579
Large intestinal stenosis 10.60 9.93 3 560624 3777 110024895
Spinal cord injury 10.59 9.93 25 560602 1640 110027032
Ventricular arrhythmia 10.58 9.93 22 560605 10065 110018607
Renal tubular necrosis 10.57 9.93 101 560526 30374 109998298
Colon gangrene 10.56 9.93 5 560622 41 110028631
Drug screen positive 10.55 9.93 62 560565 6348 110022324
Labelled drug-drug interaction issue 10.54 9.93 45 560582 4056 110024616
Basal ganglion degeneration 10.51 9.93 12 560615 424 110028248
Lip dry 10.50 9.93 614 560013 99469 109929203
Pulmonary thrombosis 10.48 9.93 112 560515 13751 110014921
Sluggishness 10.46 9.93 70 560557 7497 110021175
Tunnel vision 10.45 9.93 28 560599 1987 110026685
Vascular stent thrombosis 10.44 9.93 4 560623 4157 110024515
Cellulitis 10.43 9.93 527 560100 125489 109903183
Chronic sinusitis 10.42 9.93 182 560445 24902 110003770
Red blood cell sedimentation rate abnormal 10.41 9.93 77 560550 24432 110004240
Fractured coccyx 10.41 9.93 21 560606 1237 110027435
Sensitisation 10.40 9.93 4 560623 4147 110024525
Laryngeal pain 10.37 9.93 9 560618 5966 110022706
Stress cardiomyopathy 10.37 9.93 43 560584 15763 110012909
Pulmonary fibrosis 10.33 9.93 624 560003 101418 109927254
Dissociative amnesia 10.30 9.93 7 560620 121 110028551
Arthropathy 10.30 9.93 1288 559339 286234 109742438
Ear pruritus 10.28 9.93 13 560614 7247 110021425
Post procedural complication 10.27 9.93 86 560541 26572 110002100
Polyneuropathy idiopathic progressive 10.26 9.93 4 560623 19 110028653
Genital haemorrhage 10.25 9.93 13 560614 7239 110021433
Myopia 10.25 9.93 30 560597 2241 110026431
Abnormal loss of weight 10.24 9.93 23 560604 10234 110018438
Viraemia 10.20 9.93 4 560623 4098 110024574
Mouth ulceration 10.19 9.93 177 560450 47961 109980711
Spinal decompression 10.18 9.93 13 560614 517 110028155
Frequent bowel movements 10.17 9.93 451 560176 70939 109957733
Subdural haematoma 10.17 9.93 127 560500 36327 109992345
Device occlusion 10.15 9.93 41 560586 15144 110013528
Occipital neuralgia 10.11 9.93 15 560612 689 110027983
Interchange of vaccine products 10.09 9.93 4 560623 20 110028652
Carbon dioxide abnormal 10.04 9.93 14 560613 607 110028065
Mycobacterium avium complex infection 10.02 9.93 9 560618 5868 110022804
Rib fracture 10.02 9.93 233 560394 33537 109995135
Prerenal failure 10.01 9.93 47 560580 4412 110024260
Cardiac tamponade 10.00 9.93 27 560600 11280 110017392
Procedural complication 9.99 9.93 17 560610 8388 110020284
Cardiac output decreased 9.98 9.93 28 560599 2041 110026631
Blood pressure decreased 9.97 9.93 479 560148 114612 109914060
Electrolyte imbalance 9.96 9.93 130 560497 36898 109991774
Intrathecal pump insertion 9.95 9.93 3 560624 5 110028667
Wrong dosage formulation 9.95 9.93 3 560624 5 110028667
Hepatic enzyme 9.94 9.93 7 560620 5156 110023516
Creatinine renal clearance increased 9.94 9.93 3 560624 3622 110025050
Bronchopulmonary aspergillosis allergic 9.94 9.93 75 560552 8351 110020321
Emphysema 9.93 9.93 59 560568 19697 110008975
Immune-mediated myositis 9.93 9.93 10 560617 6176 110022496

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Congenital nystagmus 37.17 31.66 12 379 48 113514
Congenital hydrocephalus 33.79 31.66 12 379 68 113494

Pharmacologic Action:

SourceCodeDescription
ATC N02BF02 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Gabapentinoids
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000700 Analgesics
MeSH PA D000927 Anticonvulsants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

N02BF Gabapentinoids 2 drugs
gabapentinmirogabalin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Generalized anxiety disorder indication 21897009 DOID:14320
Partial seizure indication 29753000
Fibromyalgia indication 203082005 DOID:631
Peripheral neuropathic pain indication 279981003
Diabetic peripheral neuropathy indication 424736006
Central neuropathic pain indication 1259040000
Partial Epilepsy Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Reduced visual acuity contraindication 13164000
Depressive disorder contraindication 35489007
Angioedema contraindication 41291007 DOID:1558
Chronic heart failure contraindication 48447003
Disorder of muscle contraindication 129565002 DOID:423
Decompensated cardiac failure contraindication 195111005
Impaired renal function disorder contraindication 197663003
Atrioventricular block contraindication 233917008 DOID:0050820
Rhabdomyolysis contraindication 240131006
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dizziness contraindication 404640003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.97 acidic
pKa2 10.4 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel MODULATOR IC50 7.10 WOMBAT-PK CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-2 Ion channel MODULATOR IC50 7.26 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Large neutral amino acids transporter small subunit 1 Transporter IC50 3.80 WOMBAT-PK
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit Ion channel IC50 7.14 CHEMBL

External reference:

IDSource
4024924 VUID
N0000171595 NUI
D02716 KEGG_DRUG
4024924 VANDF
C0657912 UMLSCUI
CHEBI:64356 CHEBI
CHEMBL1059 ChEMBL_ID
DB00230 DRUGBANK_ID
D000069583 MESH_DESCRIPTOR_UI
5486971 PUBCHEM_CID
7643 INN_ID
5484 IUPHAR_LIGAND_ID
530085-00-8 SECONDARY_CAS_RN
55JG375S6M UNII
187832 RXNORM
19649 MMSL
67412 MMSL
79550 MMSL
d05508 MMSL
010083 NDDF
415159003 SNOMEDCT_US
415160008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1012 CAPSULE 25 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1013 CAPSULE 50 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1014 CAPSULE 75 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1015 CAPSULE 100 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1016 CAPSULE 150 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1017 CAPSULE 200 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1018 CAPSULE 300 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1019 CAPSULE 225 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1020 SOLUTION 20 mg ORAL NDA 33 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-6991 CAPSULE 25 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-6992 CAPSULE 50 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7000 CAPSULE 75 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7001 CAPSULE 100 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7002 CAPSULE 150 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7003 CAPSULE 200 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7004 CAPSULE 225 mg ORAL ANDA 20 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7005 CAPSULE 300 mg ORAL ANDA 20 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-358 CAPSULE 25 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-359 CAPSULE 50 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-360 CAPSULE 75 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-361 CAPSULE 100 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-362 CAPSULE 150 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-363 CAPSULE 200 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-364 CAPSULE 225 mg ORAL ANDA 22 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 13668-365 CAPSULE 300 mg ORAL ANDA 22 sections
pregabalin Human Prescription Drug Label 1 14445-123 CAPSULE 75 mg ORAL ANDA 32 sections
pregabalin Human Prescription Drug Label 1 14445-124 CAPSULE 100 mg ORAL ANDA 32 sections
pregabalin Human Prescription Drug Label 1 14445-125 CAPSULE 150 mg ORAL ANDA 32 sections
pregabalin Human Prescription Drug Label 1 14445-126 CAPSULE 200 mg ORAL ANDA 32 sections
pregabalin Human Prescription Drug Label 1 14445-127 CAPSULE 225 mg ORAL ANDA 32 sections