prednisolone tebutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2251 7681-14-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone tebutate
  • prednisolone tert-butylacetate
  • Prednisolone TBA
  • prednisolone butylacetate
  • HYDELTRA-TBA
  • prednisolone tertiary butylacetate
  • Molecular weight: 458.60
  • Formula: C27H38O6
  • CLOGP: 3.82
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.69
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 25, 1956 FDA MERCK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Hydeltrone-TBA Suspension Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.65 acidic
pKa2 13.36 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 9.28 CHEMBL CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor Ki 9.54 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.60 CHEMBL
Corticosteroid-binding globulin Secreted Ki 7.51 CHEMBL
Interleukin-6 Cytokine IC50 8.38 CHEMBL
G-protein coupled bile acid receptor 1 GPCR IC50 6.60 CHEMBL
Glutamine synthetase Enzyme EC50 7.50 CHEMBL
Disintegrin and metalloproteinase domain-containing protein 17 Unclassified IC50 7.83 CHEMBL
Progesterone receptor Nuclear hormone receptor IC50 5.68 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 5.58 CHEMBL
Glucocorticoid receptor Transcription factor IC50 7.28 CHEMBL
Glucocorticoid receptor Transcription factor EC50 8.47 CHEMBL

External reference:

IDSource
4017986 VUID
N0000179220 NUI
D00982 KEGG_DRUG
4017986 VANDF
4017988 VANDF
C0071844 UMLSCUI
CHEBI:8381 CHEBI
CHEBI:8378 CHEBI
TUA PDB_CHEM_ID
CHEMBL1200909 ChEMBL_ID
DB14632 DRUGBANK_ID
C009021 MESH_SUPPLEMENTAL_RECORD_UI
1V7A1U282K UNII
93055 PUBCHEM_CID
5755 PUBCHEM_CID
DB00860 DRUGBANK_ID
34376 RXNORM
5347 MMSL
5350 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
002159 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US
96336003 SNOMEDCT_US
C0032950 UMLSCUI
CHEMBL131 ChEMBL_ID
D011239 MESH_DESCRIPTOR_UI
535 INN_ID

Pharmaceutical products:

None