prednisolone steaglate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2249 5060-55-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone steaglate
  • prednisolone stearoylglycolate
  • sintisone
  • Molecular weight: 684.96
  • Formula: C41H64O8
  • CLOGP: 10.31
  • LIPINSKI: 2
  • HAC: 8
  • HDO: 2
  • TPSA: 127.20
  • ALOGS: -6.60
  • ROTB: 23
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.22 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 82 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 5.256 Moderate 0.66
caco2-efflux Caco-2 efflux ratio (BA/AB) 6.516 Moderate 0.66
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.041 10^-6 cm/s Moderate 0.66
dh-clint Dog hepatocyte intrinsic clearance 207.970 uL/min/10^6 cells Moderate 0.66
dppb Dog plasma protein binding (% unbound) 0.070 % Moderate 0.66
fcs-ppb Fetal calf serum protein binding (% unbound) 0.030 % Moderate 0.66
herg hERG pIC50 4.644 pIC50 Moderate 0.66
hh-clint Human hepatocyte intrinsic clearance 691.831 uL/min/10^6 cells Moderate 0.66
hlm-clint Human liver microsomal intrinsic clearance 205.116 uL/min/mg protein Moderate 0.66
hppb Human plasma protein binding (% unbound) 0.190 % Moderate 0.66
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 61
kinase-selectivity-class AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,PLK1,STK33,TEK 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.157 Moderate 0.67
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.202 Moderate 0.66
mh-clint Mouse hepatocyte intrinsic clearance 250.035 Moderate 0.66
mppb Mouse plasma protein binding (% unbound) 0.130 Moderate 0.66
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.710 Moderate 0.66
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.67
pppb Pig plasma protein binding (% unbound) 0.190 % Moderate 0.66
rat-kpuu-brain Rat brain Kpuu 37.497 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 140.929 uL/min/10^6 cells Moderate 0.66
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.040 % Moderate 0.66
rppb Rat plasma protein binding (% unbound) 0.160 % Moderate 0.66
solubility-dd Solubility at pH 7.4 in DMSO 0.716 uM Moderate 0.66

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35816 leprostatic drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37962 adrenergic agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50671 antithyroid drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76595 nephroprotective agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.65 acidic
pKa2 13.36 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08415 KEGG_DRUG
4017988 VANDF
C2825346 UMLSCUI
CHEBI:135871 CHEBI
TUA PDB_CHEM_ID
CHEMBL2105774 ChEMBL_ID
C003312 MESH_SUPPLEMENTAL_RECORD_UI
2071 INN_ID
OZQ2XN817F UNII
71206 PUBCHEM_CID
8638 RXNORM
5347 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US
C0032950 UMLSCUI
DB00860 DRUGBANK_ID
5755 PUBCHEM_CID
535 INN_ID
D011239 MESH_DESCRIPTOR_UI
CHEBI:8378 CHEBI
OZQ2XN817F INXIGHT DRUGS

Pharmaceutical products:

None