prednimustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives | 2244 | 29069-24-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.09 mg/mL | Bocci G, Oprea TI, Benet LZ |
| S (Water solubility) | 0.22 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01AA08 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ALKYLATING AGENTS Nitrogen mustard analogues |
| FDA MoA | N0000000236 | Alkylating Activity |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175558 | Alkylating Drug |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000477 | Alkylating Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018906 | Antineoplastic Agents, Alkylating |
| MeSH PA | D009676 | Noxae |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D005938 | Glucocorticoids |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
| CHEBI has role | CHEBI:50903 | carcinogen |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.65 | acidic |
| pKa2 | 13.36 | acidic |
| pKa3 | 4.68 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167429 | NUI |
| D05602 | KEGG_DRUG |
| 4017988 | VANDF |
| 4018769 | VANDF |
| C0032949 | UMLSCUI |
| CHEBI:82524 | CHEBI |
| CHEBI:8378 | CHEBI |
| CHEBI:28830 | CHEBI |
| TUA | PDB_CHEM_ID |
| CBL | PDB_CHEM_ID |
| CHEMBL2103751 | ChEMBL_ID |
| D011238 | MESH_DESCRIPTOR_UI |
| DB12832 | DRUGBANK_ID |
| 3518 | INN_ID |
| 9403SIO2S8 | UNII |
| 34457 | PUBCHEM_CID |
| DB00860 | DRUGBANK_ID |
| DB00291 | DRUGBANK_ID |
| 2346 | RXNORM |
| 4405 | MMSL |
| 5347 | MMSL |
| 59710 | MMSL |
| 71849 | MMSL |
| d00084 | MMSL |
| d00188 | MMSL |
| 002155 | NDDF |
| 002632 | NDDF |
| 005392 | NDDF |
| 116601002 | SNOMEDCT_US |
| 387249003 | SNOMEDCT_US |
| 46009007 | SNOMEDCT_US |
| 52388000 | SNOMEDCT_US |
| C0032950 | UMLSCUI |
| C0008163 | UMLSCUI |
| 535 | INN_ID |
| 603 | INN_ID |
| 5755 | PUBCHEM_CID |
| 2708 | PUBCHEM_CID |
| D011239 | MESH_DESCRIPTOR_UI |
| D002699 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None