octatropine methylbromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| atropine derivatives | 223 | 80-50-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 17.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 23, 1962 | FDA | ENDO PHARMS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:48876 | muscarinic antagonists |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| CHEBI has role | CHEBI:50370 | parasympatholytics |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018727 | Muscarinic Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Peptic ulcer | indication | 13200003 | DOID:750 |
| Gastric ulcer | indication | 397825006 | DOID:10808 |
| Irritable bowel syndrome | off-label use | 10743008 | DOID:9778 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | DRUGBANK | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018547 | VUID |
| N0000179041 | NUI |
| 17945 | RXNORM |
| C0051923 | UMLSCUI |
| CHEBI:2739 | CHEBI |
| CHEMBL1578 | ChEMBL_ID |
| 657201 | PUBCHEM_CID |
| DB00517 | DRUGBANK_ID |
| C100237 | MESH_SUPPLEMENTAL_RECORD_UI |
| 367554003 | SNOMEDCT_US |
| 913 | INN_ID |
| 4018547 | VANDF |
| 62M960DHIL | UNII |
| 001748 | NDDF |
Pharmaceutical products:
None