octatropine methylbromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 223 80-50-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octatropine methylbromide
  • anisotropine methylbromide
  • anisotropine methobromide
  • anisotropine methyl bromide
  • valpin
minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer
  • Molecular weight: 282.45
  • Formula: C17H32NO2
  • CLOGP: -0.82
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -6.61
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 17.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Nov. 23, 1962 FDA ENDO PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:50370 parasympatholytics
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST DRUGBANK CHEMBL
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST DRUGBANK CHEMBL

External reference:

IDSource
4018547 VUID
N0000179041 NUI
17945 RXNORM
C0051923 UMLSCUI
CHEBI:2739 CHEBI
CHEMBL1578 ChEMBL_ID
657201 PUBCHEM_CID
DB00517 DRUGBANK_ID
C100237 MESH_SUPPLEMENTAL_RECORD_UI
367554003 SNOMEDCT_US
913 INN_ID
4018547 VANDF
62M960DHIL UNII
001748 NDDF

Pharmaceutical products:

None