anileridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesics, pethidine derivatives and other synthetic small molecule miu-opioid receptor agonists 220 144-14-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anileridine
  • adopol
  • alidine
  • apidol
  • leritin
  • leritine
  • nipecotan
  • anileridine hydrochloride
  • anileridine phosphate
  • anileridine HCl
  • anileridine monohydrochloride
  • anileridine dihydrochloride
minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd
  • Molecular weight: 352.48
  • Formula: C22H28N2O2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.56
  • ALOGS: -4.46
  • ROTB: 7
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.45 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA MERCK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AH05 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:60606 opioid agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.29 Basic
pKa2 3.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST WOMBAT-PK CHEMBL

External reference:

IDSource
D02941 KEGG_DRUG
17933 RXNORM
C0051908 UMLSCUI
CHEBI:61203 CHEBI
CHEMBL1201347 ChEMBL_ID
DB00913 DRUGBANK_ID
C100232 MESH_SUPPLEMENTAL_RECORD_UI
8944 PUBCHEM_CID
7115 IUPHAR_LIGAND_ID
528 INN_ID
126-12-5 SECONDARY_CAS_RN
4268-37-5 SECONDARY_CAS_RN
71Q1A3O279 UNII
55793008 SNOMEDCT_US
CHEMBL1201047 ChEMBL_ID
CHEMBL1200543 ChEMBL_ID
001560 NDDF
001561 NDDF
001562 NDDF

Pharmaceutical products:

None