piretanide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diuretics, piretanide derivatives | 2201 | 55837-27-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
potent inhibitor of chloride transport; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.55 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 92 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1980 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Stevens-Johnson syndrome | 71.71 | 71.36 | 17 | 180 | 39149 | 79705042 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03CA03 | CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D045283 | Natriuretic Agents |
| MeSH PA | D049994 | Sodium Potassium Chloride Symporter Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Edema | indication | 267038008 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.58 | acidic |
| pKa2 | 9.66 | acidic |
| pKa3 | 3.92 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 12 member 1 | Transporter | INHIBITOR | Kd | 8.30 | WOMBAT-PK | KEGG DRUG | |||
| Solute carrier family 12 member 2 | Transporter | INHIBITOR | IC50 | 5.62 | IUPHAR | KEGG DRUG |
External reference:
| ID | Source |
|---|---|
| D01634 | KEGG_DRUG |
| C0071132 | UMLSCUI |
| CHEBI:32015 | CHEBI |
| CHEMBL349803 | ChEMBL_ID |
| DB02925 | DRUGBANK_ID |
| C015451 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4849 | PUBCHEM_CID |
| 4742 | IUPHAR_LIGAND_ID |
| 3741 | INN_ID |
| DQ6KK6GV93 | UNII |
| 151370 | RXNORM |
| 23252 | MMSL |
| 004024 | NDDF |
| 318031002 | SNOMEDCT_US |
| 419451002 | SNOMEDCT_US |
Pharmaceutical products:
None