anhydrovinblastine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vinca alkaloids	219	38390-45-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

anhydrovinblastine
anhydrovincaleukoblastine

Molecular weight: 792.97
Formula: C46H56N4O8
CLOGP: 5.19
LIPINSKI: 3
HAC: 12
HDO: 2
TPSA: 133.87
ALOGS: -5.01
ROTB: 10

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution)	12 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	12 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	18 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1965	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.32	acidic
pKa2	13.81	acidic
pKa3	7.58	Basic
pKa4	6.94	Basic
pKa5	6.11	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN					WOMBAT-PK
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 7	Transporter	Q5T3U5	MRP7_HUMAN					WOMBAT-PK
Tubulin beta-4B chain	Structural	P68371	TBB4B_HUMAN					WOMBAT-PK

External reference:

ID	Source
C0796616	UMLSCUI
CHEBI:1322	CHEBI
DB12586	DRUGBANK_ID
5B622U08B3	UNII
11104750	PUBCHEM_CID

Pharmaceutical products:

None