AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
piperazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2188 | 110-85-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has anthelmintic action
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 260 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 580.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IRAK1,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK7,MAPKAPK2,MARK4,MET,NTRK1,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 51 | |||
| kinase-selectivity-class | AKT1,AKT3,ALK,AURKB,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK4,CHEK1,CLK2,CSF1R,CSK,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,FGFR1,FLT3,GAK,HASPIN,INSR,IRAK1,IRAK4,JAK1,KDR,KIT,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK7,MARK4,MELK,NTRK1,PAK1,PAK2,PAK4,PDK4,PDPK1,PRKCD,SIK2,SIK3,SRC,STK33,SYK,TTK,TYRO3,ULK1,ULK2 | 53 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 12, 1954 | FDA | BLULINE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CB01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Piperazine and derivatives |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
Related Drugs by ATC class:
P02CB Piperazine and derivatives 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ascariasis | indication | 2435008 | DOID:456 |
| Enterobiasis | indication | 266162007 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chickens | Removal of large roundworms, Ascaridia species | Indication |
| Cats | Removal of large roundworms, Toxocara canis | Indication |
| Cats | Removal of large roundworms, Toxascaris leonina | Indication |
| Dogs | Removal of immature (fourth stage larvae) and adult hookworms, Ancylostoma caninum | Indication |
| Dogs | Removal of immature (fourth stage larvae) and adult hookworms, A braziliense | Indication |
| Dogs | Removal of immature (fourth stage larvae) and adult hookworms, Uncinaria stenocephala | Indication |
| Dogs | Removal of ascarids, Toxocara canis | Indication |
| Horses | Removal of ascarids, Parascaris equorum | Indication |
| Horses | Removal of bots, Gastrophilus species | Indication |
| Horses | Removal of small strongyles | Indication |
| Horses | Removal of large strongyles | Indication |
| Horses | Removal of pinworms, Oxyuris equi | Indication |
| Swine | Removal of large roundworms, Ascaris suum | Indication |
| Swine | Removal of nodular worms, Oesophagostomum species | Indication |
| Turkeys | Removal of large roundworms, Ascaridia species | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Parvex Suspension | Zoetis Inc. | 1 |
| Parvex Bolus | Zoetis Inc. | 1 |
| Dizan Suspension With Piperazine | Cronus Pharma Specialities India Private Limited | 2 |
| Dyrex T.F - 1000, Dyrex T.F - 200, Dyrex T.F - 500 | Zoetis Inc. | 3 |
| Parvex Plus Suspension | Zoetis Inc. | 2 |
| Equizole A | Boehringer lngelheim Animal Health USA Inc. | 2 |
| Equizole A Liquid | Boehringer lngelheim Animal Health USA Inc. | 2 |
| Ripercol L-Piperazine Soluble | Zoetis Inc. | 2 |
| Sergeants Worm Away For Dogs | Sergeant?s Pet Care Products LLC | 1 |
| Sergeants Worm Away For Cats | Sergeant?s Pet Care Products LLC | 1 |
| Ripercol L-Piperazine | Zoetis Inc. | 2 |
| Thenatol PW Tablets | Intervet Inc. | 2 |
| Purina Liquid Dog Wormer | Farnam Companies Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.39 | Basic |
| pKa2 | 6.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 1RTM4PAL0V | UNII |
| D00807 | KEGG_DRUG |
| 18534-18-4 | SECONDARY_CAS_RN |
| 4018854 | VANDF |
| 4019897 | VANDF |
| C0031957 | UMLSCUI |
| CHEBI:28568 | CHEBI |
| PZE | PDB_CHEM_ID |
| CHEMBL1412 | ChEMBL_ID |
| 4837 | PUBCHEM_CID |
| DB00592 | DRUGBANK_ID |
| CHEMBL2105892 | ChEMBL_ID |
| CHEMBL3989678 | ChEMBL_ID |
| D000077489 | MESH_DESCRIPTOR_UI |
| 7140-78-5 | SECONDARY_CAS_RN |
| 1549138 | RXNORM |
| 5408 | MMSL |
| NOCODE | MMSL |
| d01124 | MMSL |
| 002977 | NDDF |
| 002978 | NDDF |
| 002979 | NDDF |
| 26109001 | SNOMEDCT_US |
| 428714003 | SNOMEDCT_US |
| 771347005 | SNOMEDCT_US |
| 96114007 | SNOMEDCT_US |
| 3597-26-0 | SECONDARY_CAS_RN |
| 142-64-3 | SECONDARY_CAS_RN |
| 7542-23-6 | SECONDARY_CAS_RN |
| 55871-03-9 | SECONDARY_CAS_RN |
| C006589 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None