piperazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2188 | 110-85-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has anthelmintic action
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 260 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 580.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 12, 1954 | FDA | BLULINE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CB01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Piperazine and derivatives |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ascariasis | indication | 2435008 | DOID:456 |
| Enterobiasis | indication | 266162007 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.39 | Basic |
| pKa2 | 6.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D000077489 | MESH_DESCRIPTOR_UI |
| C0137095 | UMLSCUI |
| D00807 | KEGG_DRUG |
| 1RTM4PAL0V | UNII |
| 7140-78-5 | SECONDARY_CAS_RN |
| 428714003 | SNOMEDCT_US |
| 771347005 | SNOMEDCT_US |
| 4019897 | VANDF |
| d01124 | MMSL |
| 8340 | RXNORM |
| 5408 | MMSL |
| 002977 | NDDF |
| 4837 | PUBCHEM_CID |
| CHEBI:28568 | CHEBI |
| CHEMBL1412 | ChEMBL_ID |
| DB00592 | DRUGBANK_ID |
| PZE | PDB_CHEM_ID |
| CHEMBL2105892 | ChEMBL_ID |
| CHEMBL2219733 | ChEMBL_ID |
| CHEMBL3989678 | ChEMBL_ID |
| CHEMBL3990694 | ChEMBL_ID |
| C006589 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None