piperazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2188 110-85-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piperazine phosphate hydrate
  • piperazine phosphate
  • piperazine
  • antiren
  • eraverm
  • pipersol
  • 1,4-piperazine
  • piperazine citrate
  • multifuge
has anthelmintic action
  • Molecular weight: 86.14
  • Formula: C4H10N2
  • CLOGP: -1.48
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 24.06
  • ALOGS: 0.63
  • ROTB: 0

Drug dosage:

DoseUnitRoute
3.50 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 260 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 580.47 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
July 12, 1954 FDA BLULINE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CB01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Piperazine and derivatives
CHEBI has role CHEBI:35443 anthelminthic drug
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ascariasis indication 2435008 DOID:456
Enterobiasis indication 266162007
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.39 Basic
pKa2 6.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit beta Ion channel WOMBAT-PK

External reference:

IDSource
D000077489 MESH_DESCRIPTOR_UI
C0137095 UMLSCUI
D00807 KEGG_DRUG
1RTM4PAL0V UNII
7140-78-5 SECONDARY_CAS_RN
428714003 SNOMEDCT_US
771347005 SNOMEDCT_US
4019897 VANDF
d01124 MMSL
8340 RXNORM
5408 MMSL
002977 NDDF
4837 PUBCHEM_CID
CHEBI:28568 CHEBI
CHEMBL1412 ChEMBL_ID
DB00592 DRUGBANK_ID
PZE PDB_CHEM_ID
CHEMBL2105892 ChEMBL_ID
CHEMBL2219733 ChEMBL_ID
CHEMBL3989678 ChEMBL_ID
CHEMBL3990694 ChEMBL_ID
C006589 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None