piperazine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2188 110-85-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piperazine phosphate hydrate
  • piperazine phosphate
  • piperazine
  • antiren
  • eraverm
  • pipersol
  • 1,4-piperazine
  • piperazine citrate
  • multifuge
  • piperazine sulfate
  • dipiperazine sulfate
  • dipiperazine
  • piperazine dihydrochloride
  • piperazine monohydrochloride
  • piperazine-carbon disulfide complex
has anthelmintic action
  • Molecular weight: 86.14
  • Formula: C4H10N2
  • CLOGP: -1.48
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 24.06
  • ALOGS: 0.63
  • ROTB: 0

Drug dosage:

DoseUnitRoute
3.50 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 260 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 580.47 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
July 12, 1954 FDA BLULINE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CB01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Piperazine and derivatives
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000969 Antinematodal Agents
CHEBI has role CHEBI:35443 anthelmintics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ascariasis indication 2435008 DOID:456
Enterobiasis indication 266162007
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Chickens Removal of large roundworms, Ascaridia species Indication
Cats Removal of large roundworms, Toxocara canis Indication
Cats Removal of large roundworms, Toxascaris leonina Indication
Dogs Removal of immature (fourth stage larvae) and adult hookworms, Ancylostoma caninum Indication
Dogs Removal of immature (fourth stage larvae) and adult hookworms, A braziliense Indication
Dogs Removal of immature (fourth stage larvae) and adult hookworms, Uncinaria stenocephala Indication
Dogs Removal of ascarids, Toxocara canis Indication
Horses Removal of ascarids, Parascaris equorum Indication
Horses Removal of bots, Gastrophilus species Indication
Horses Removal of small strongyles Indication
Horses Removal of large strongyles Indication
Horses Removal of pinworms, Oxyuris equi Indication
Swine Removal of large roundworms, Ascaris suum Indication
Swine Removal of nodular worms, Oesophagostomum species Indication
Turkeys Removal of large roundworms, Ascaridia species Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Parvex Suspension Zoetis Inc. 1
Parvex Bolus Zoetis Inc. 1
Dizan Suspension With Piperazine Cronus Pharma Specialities India Private Limited 2
Dyrex T.F - 1000, Dyrex T.F - 200, Dyrex T.F - 500 Zoetis Inc. 3
Parvex Plus Suspension Zoetis Inc. 2
Equizole A Boehringer lngelheim Animal Health USA Inc. 2
Equizole A Liquid Boehringer lngelheim Animal Health USA Inc. 2
Ripercol L-Piperazine Soluble Zoetis Inc. 2
Sergeants Worm Away For Dogs Sergeant?s Pet Care Products LLC 1
Sergeants Worm Away For Cats Sergeant?s Pet Care Products LLC 1
Ripercol L-Piperazine Zoetis Inc. 2
Thenatol PW Tablets Intervet Inc. 2
Purina Liquid Dog Wormer Farnam Companies Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.39 Basic
pKa2 6.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit beta Ion channel WOMBAT-PK

External reference:

IDSource
1RTM4PAL0V UNII
D00807 KEGG_DRUG
18534-18-4 SECONDARY_CAS_RN
4018854 VANDF
4019897 VANDF
C0031957 UMLSCUI
CHEBI:28568 CHEBI
PZE PDB_CHEM_ID
CHEMBL1412 ChEMBL_ID
4837 PUBCHEM_CID
DB00592 DRUGBANK_ID
CHEMBL2219733 ChEMBL_ID
CHEMBL2105892 ChEMBL_ID
D000077489 MESH_DESCRIPTOR_UI
C006589 MESH_SUPPLEMENTAL_RECORD_UI
7140-78-5 SECONDARY_CAS_RN
3597-26-0 SECONDARY_CAS_RN
1549138 RXNORM
5408 MMSL
NOCODE MMSL
d01124 MMSL
002977 NDDF
002978 NDDF
002979 NDDF
26109001 SNOMEDCT_US
428714003 SNOMEDCT_US
771347005 SNOMEDCT_US
96114007 SNOMEDCT_US
CHEMBL3990694 ChEMBL_ID
CHEMBL3989678 ChEMBL_ID
142-64-3 SECONDARY_CAS_RN
7542-23-6 SECONDARY_CAS_RN
55871-03-9 SECONDARY_CAS_RN

Pharmaceutical products:

None