anecortave 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 217 7753-60-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anecortave acetate
  • anecortave
  • retaane
  • Molecular weight: 386.49
  • Formula: C23H30O5
  • CLOGP: 2.87
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.53
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 2006 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01LA02 SENSORY ORGANS
OPHTHALMOLOGICALS
OCULAR VASCULAR DISORDER AGENTS
Antineovascularisation agents
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Exudative age-related macular degeneration indication 414173003 DOID:10873




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Plasminogen activator inhibitor 1 Secreted WOMBAT-PK

External reference:

IDSource
D01733 KEGG_DRUG
CHEBI:31215 CHEBI
CHEMBL2106613 ChEMBL_ID
C108424 MESH_SUPPLEMENTAL_RECORD_UI
C418047 MESH_SUPPLEMENTAL_RECORD_UI
DB12081 DRUGBANK_ID
R5Y8O51589 UNII
DB05288 DRUGBANK_ID
C1693912 UMLSCUI
7747 INN_ID
7074810 PUBCHEM_CID
10184-70-0 SECONDARY_CAS_RN
011285 NDDF
011286 NDDF

Pharmaceutical products:

None