piketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 2165 60576-13-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calmatel
  • piketoprofen
  • Molecular weight: 344.41
  • Formula: C22H20N2O2
  • CLOGP: 3.88
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 59.06
  • ALOGS: -5.16
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK1,CDK14,CDK16,CDK19,CDK2,CDK3,CDK5,CDK6,CDK7,CDK9,CLK4,CSF1R,DDR1,DYRK1A,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK1,GRK2,GSK3A,GSK3B,IRAK1,ITK,JAK1,KDR,KIT,LYN,MAP3K1,MAP3K10,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK11,MAPK14,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,NTRK1,NTRK2,PDK2,PDK4,PIK3CD,PIK3CG,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,TYRO3,ULK1,ULK2 73
kinase-selectivity-class ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK1,CDK9,DDR1,DYRK1B,ERBB2,GRK2,JAK1,MAP3K21,MAPK7,PIK3CD,SIK2,SIK3,STK33 18
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA28 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use

Related Drugs by ATC class:

M02AA Antiinflammatory preparations, non-steroids for topical use 28 drugs
aceclofenacbendazacbenzydaminebufexamacclofezonedexketoprofendiclofenacesflurbiprofenetofenamatefelbinacfentiazacfeprazone show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.9 acidic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR KEGG DRUG KEGG DRUG

External reference:

IDSource
D08374 KEGG_DRUG
C0285260 UMLSCUI
CHEBI:135455 CHEBI
CHEMBL2106966 ChEMBL_ID
C048832 MESH_SUPPLEMENTAL_RECORD_UI
68801 PUBCHEM_CID
4556 INN_ID
362QBC4NL0 UNII
82910 RXNORM
009027 NDDF
136501000146105 SNOMEDCT_US

Pharmaceutical products:

None