piketoprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 2165 60576-13-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calmatel
  • piketoprofen
  • Molecular weight: 344.41
  • Formula: C22H20N2O2
  • CLOGP: 3.88
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 59.06
  • ALOGS: -5.16
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M02AA28 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.9 acidic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG

External reference:

IDSource
C0285260 UMLSCUI
D08374 KEGG_DRUG
362QBC4NL0 UNII
4556 INN_ID
82910 RXNORM
009027 NDDF
CHEBI:135455 CHEBI
CHEMBL2106966 ChEMBL_ID
68801 PUBCHEM_CID
C048832 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None