picrotin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2163	21416-53-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

picrotin

the less toxic component of picrotoxin lacking GABA activity

Molecular weight: 310.30
Formula: C15H18O7
CLOGP: -1.61
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 105.59
ALOGS: -1.10
ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.46	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN		IC50	5.28		CHEMBL
Glycine receptor subunit alpha-2	Ion channel	P23416	GLRA2_HUMAN	BLOCKER	IC50	4.90		IUPHAR
Glycine receptor subunit beta	Ion channel	P48167	GLRB_HUMAN	BLOCKER	IC50	4.60		IUPHAR
Glycine receptor subunit alpha-3	Ion channel	O75311	GLRA3_HUMAN		IC50	5.22		CHEMBL

External reference:

ID	Source
C0916220	UMLSCUI
CHEMBL478523	ChEMBL_ID
C411705	MESH_SUPPLEMENTAL_RECORD_UI
442291	PUBCHEM_CID
4286	IUPHAR_LIGAND_ID
U06Z6QD7N2	UNII

Pharmaceutical products:

None