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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2162 | 124-87-8 |
| Molecule | Description |
|---|---|
|
Synonyms:
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A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
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| Source | Code | Description |
|---|---|---|
| MeSH PA | D000697 | Central Nervous System Stimulants |
| MeSH PA | D000931 | Antidotes |
| MeSH PA | D003292 | Convulsants |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018756 | GABA Antagonists |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D058787 | GABA-A Receptor Antagonists |
| CHEBI has role | CHEBI:35337 | central nervous system stimulant |
| CHEBI has role | CHEBI:65259 | GABA antagonist |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:134173 | antidote to barbiturate poisoning |
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| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Ion channel | BLOCKER | IC50 | 5.20 | IUPHAR | ||||
| Glycine receptor subunit alpha-2 | Ion channel | BLOCKER | IC50 | 5.60 | IUPHAR | ||||
| Glycine receptor subunit beta | Ion channel | BLOCKER | IC50 | 4.50 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 3A | Ion channel | BLOCKER | IC50 | 4.50 | IUPHAR | ||||
| GABA-A receptor; anion channel | Ion channel | IC50 | 5.88 | CHEMBL |
| ID | Source |
|---|---|
| C0031890 | UMLSCUI |
| RI5 | PDB_CHEM_ID |
| CHEMBL1908342 | ChEMBL_ID |
| DB00466 | DRUGBANK_ID |
| D010852 | MESH_DESCRIPTOR_UI |
| 31304 | PUBCHEM_CID |
| 4051 | IUPHAR_LIGAND_ID |
| ZLT174DL7U | UNII |
| 2539172 | RXNORM |
| 001378 | NDDF |
| 57979006 | SNOMEDCT_US |
| CHEBI:134126 | CHEBI |
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