oxagrelate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
platelet aggregation inhibitors	2156	56611-65-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

oxagrelate
phthalazinol
EG 626

Molecular weight: 276.29
Formula: C14H16N2O4
CLOGP: 0.61
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 87.99
ALOGS: -3.24
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D010726	Phosphodiesterase Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.9	acidic
pKa2	13.44	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Phosphodiesterase 3	Enzyme	Q13370 Q14432	PDE3B_HUMAN PDE3A_HUMAN		Ki	5.85		CHEMBL
Phosphodiesterase 1	Enzyme	P54750 Q01064 Q14123	PDE1A_HUMAN PDE1B_HUMAN PDE1C_HUMAN		Ki	5		CHEMBL

External reference:

ID	Source
V17MYO89WO	UNII
D05278	KEGG_DRUG
C2825274	UMLSCUI
CHEBI:135142	CHEBI
CHEMBL153427	ChEMBL_ID
41946	PUBCHEM_CID
5187	INN_ID
C011329	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None