oxagrelate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 2156 56611-65-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxagrelate
  • phthalazinol
  • EG 626
  • Molecular weight: 276.29
  • Formula: C14H16N2O4
  • CLOGP: 0.61
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 87.99
  • ALOGS: -3.24
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.9 acidic
pKa2 13.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phosphodiesterase 1 Enzyme Ki 5 CHEMBL
Phosphodiesterase 3 Enzyme Ki 5.85 CHEMBL

External reference:

IDSource
D05278 KEGG_DRUG
C0115563 UMLSCUI
CHEBI:135142 CHEBI
CHEMBL153427 ChEMBL_ID
C011329 MESH_SUPPLEMENTAL_RECORD_UI
41946 PUBCHEM_CID
5187 INN_ID
V17MYO89WO UNII

Pharmaceutical products:

None