phenylephrine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 2146 59-42-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (-)-Phenylephrine
  • (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • (-)-m-Oxedrine
  • (-)-m-Synephrine
  • (R)-Phenylephrine
  • L-Phenylephedrine
  • mesatone
  • metaoxedrin
  • metaoxedrine
  • metasympatol
  • metasynephrine
  • mezaton
  • l-Phenylephrine
  • phenylephrine
  • phenylephrine hydrochloride
  • phenylephrine tannate
  • phenylephrine bitartrate
  • phenylephrine HCl
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
  • Molecular weight: 167.21
  • Formula: C9H13NO2
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -0.88
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg P
4 mg N
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.98 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1194.08 10.22 3609 538208 128280 49935027
Toxicity to various agents 981.76 10.22 4688 537129 207811 49855496
Infusion related reaction 590.12 10.22 3461 538356 166096 49897211
Sinusitis 511.55 10.22 3351 538466 167207 49896100
Acute hepatic failure 400.81 10.22 652 541165 15025 50048282
Exposure to toxic agent 387.21 10.22 318 541499 3340 50059967
Blood pressure fluctuation 323.20 10.22 980 540837 34843 50028464
Folliculitis 295.71 10.22 1009 540808 38216 50025091
Muscle injury 293.37 10.22 970 540847 36141 50027166
Irritable bowel syndrome 288.02 10.22 1203 540614 50238 50013069
Lower respiratory tract infection 234.99 10.22 1785 540032 93416 49969891
Overdose 229.10 10.22 1839 539978 97888 49965419
Intentional product misuse 225.95 10.22 1046 540771 45688 50017619
Ill-defined disorder 199.07 10.22 1130 540687 53524 50009783
Drug interaction 197.15 10.22 1289 540528 198332 49864975
Nasopharyngitis 195.83 10.22 3026 538791 189901 49873406
Sleep disorder due to general medical condition, insomnia type 180.36 10.22 741 541076 30706 50032601
Metabolic acidosis 173.87 10.22 850 540967 37975 50025332
Device expulsion 173.21 10.22 47 541770 28775 50034532
Injection site pain 172.05 10.22 610 541207 110414 49952893
Blister 169.65 10.22 1525 540292 83893 49979414
Drug ineffective 157.97 10.22 7173 534644 812160 49251147
Anion gap 155.44 10.22 115 541702 1022 50062285
Sopor 152.91 10.22 17 541800 19862 50043445
Body temperature increased 149.64 10.22 699 541118 30642 50032665
Local anaesthetic systemic toxicity 136.84 10.22 84 541733 528 50062779
Neutropenia 136.29 10.22 975 540842 146990 49916317
Impaired healing 135.03 10.22 1239 540578 68547 49994760
Blood pressure increased 133.76 10.22 2085 539732 131047 49932260
Ear pain 128.63 10.22 622 541195 27661 50035646
Rheumatoid arthritis 128.17 10.22 2954 538863 199596 49863711
Peripheral swelling 127.73 10.22 2995 538822 202941 49860366
Anaemia 125.83 10.22 1923 539894 250533 49812774
Drug resistance 123.87 10.22 26 541791 18963 50044344
Gastrointestinal disorder 123.01 10.22 1549 540268 92907 49970400
Blood pressure diastolic abnormal 122.65 10.22 294 541523 9067 50054240
Hepatotoxicity 118.29 10.22 591 541226 26635 50036672
Cardiac failure 116.30 10.22 420 541397 75620 49987687
Injection site erythema 115.87 10.22 412 541405 74524 49988783
Heart rate decreased 113.35 10.22 724 541093 35773 50027534
Weight increased 111.37 10.22 2890 538927 199001 49864306
Heart rate increased 109.34 10.22 1287 540530 75963 49987344
Duodenal ulcer perforation 108.99 10.22 849 540968 44762 50018545
Helicobacter infection 108.38 10.22 906 540911 48796 50014511
Pruritus 104.22 10.22 3863 537954 279705 49783602
Osteonecrosis of jaw 103.68 10.22 117 541700 32409 50030898
Muscle spasticity 100.97 10.22 408 541409 16776 50046531
Oxygen saturation decreased 100.88 10.22 1214 540603 72034 49991273
Joint swelling 100.13 10.22 3382 538435 241904 49821403
Intentional product use issue 99.96 10.22 1261 540556 75657 49987650
Acute kidney injury 98.55 10.22 1783 540034 226275 49837032
Pancytopenia 96.40 10.22 517 541300 83513 49979794
Bone marrow failure 95.20 10.22 93 541724 27531 50035776
Wrong technique in product usage process 94.19 10.22 293 541524 55217 50008090
Blood pressure systolic increased 92.68 10.22 674 541143 34775 50028532
Hyponatraemia 91.67 10.22 627 541190 95512 49967795
Injection site reaction 91.47 10.22 255 541562 49777 50013530
Blood pressure systolic abnormal 91.42 10.22 233 541584 7473 50055834
Throat irritation 90.92 10.22 595 541222 29644 50033663
Malignant neoplasm progression 90.40 10.22 398 541419 67726 49995581
Coagulopathy 89.94 10.22 406 541411 17538 50045769
Stomatitis 89.45 10.22 1554 540263 99790 49963517
Intentional overdose 83.91 10.22 1031 540786 61473 50001834
Toxic anterior segment syndrome 83.15 10.22 93 541724 1472 50061835
Analgesic drug level increased 82.09 10.22 97 541720 1634 50061673
Hepatic enzyme increased 81.44 10.22 1986 539831 135394 49927913
Infusion site pain 80.56 10.22 303 541514 12043 50051264
Thrombocytopenia 80.10 10.22 927 540890 126746 49936561
Drug hypersensitivity 79.57 10.22 2062 539755 248948 49814359
Product dose omission issue 78.84 10.22 1439 540378 182399 49880908
Medication error 78.63 10.22 658 541159 35446 50027861
Abortion spontaneous 78.54 10.22 210 541607 41562 50021745
Mucosal inflammation 78.38 10.22 198 541619 39944 50023363
Interstitial lung disease 77.84 10.22 299 541518 52877 50010430
Infusion site swelling 73.03 10.22 205 541612 6971 50056336
Blood pressure diastolic decreased 72.70 10.22 364 541453 16417 50046890
Anti-cyclic citrullinated peptide antibody positive 72.55 10.22 1110 540707 69477 49993830
Urine abnormality 72.33 10.22 187 541630 6051 50057256
Psoriasis 71.88 10.22 438 541379 68562 49994745
Hypersensitivity 70.68 10.22 2896 538921 212265 49851042
Infusion site erythema 69.74 10.22 229 541588 8498 50054809
Urticaria 69.44 10.22 1848 539969 127713 49935594
Leukopenia 69.12 10.22 431 541386 67097 49996210
Injection site pruritus 68.06 10.22 214 541603 40197 50023110
Infusion site extravasation 67.80 10.22 196 541621 6780 50056527
Hyperkalaemia 67.46 10.22 275 541542 47814 50015493
Pericarditis 66.00 10.22 1197 540620 77492 49985815
Urine leukocyte esterase positive 65.81 10.22 114 541703 2769 50060538
Acute lung injury 62.68 10.22 76 541741 1317 50061990
Respiratory arrest 62.23 10.22 541 541276 29468 50033839
Night sweats 61.86 10.22 590 541227 32984 50030323
Injection site bruising 61.71 10.22 195 541622 36573 50026734
Sedation complication 61.28 10.22 220 541597 8546 50054761
Therapeutic product effect decreased 60.89 10.22 1897 539920 134153 49929154
Blood parathyroid hormone decreased 60.39 10.22 4 541813 7110 50056197
Red blood cell sedimentation rate abnormal 59.90 10.22 52 541765 16291 50047016
Septic shock 59.00 10.22 364 541453 56811 50006496
Hepatic cytolysis 58.91 10.22 206 541611 7897 50055410
Myelosuppression 58.65 10.22 36 541781 13481 50049826
Alopecia 56.16 10.22 2101 539716 242946 49820361
Blood pressure diastolic increased 55.66 10.22 191 541626 7252 50056055
Depressed level of consciousness 54.55 10.22 820 540997 51133 50012174
Product prescribing error 54.06 10.22 88 541729 20873 50042434
Urinary sediment present 53.89 10.22 85 541732 1906 50061401
White blood cells urine positive 53.87 10.22 138 541679 4440 50058867
Lactic acidosis 53.83 10.22 180 541637 33175 50030132
Injection site swelling 53.64 10.22 247 541570 41526 50021781
Cytomegalovirus infection 52.60 10.22 69 541748 17893 50045414
Respiratory depression 52.37 10.22 261 541556 11749 50051558
Hospitalisation 52.19 10.22 470 541347 67467 49995840
Epilepsy 51.55 10.22 95 541722 21472 50041835
Headache 51.02 10.22 6180 535637 500355 49562952
Posterior reversible encephalopathy syndrome 50.59 10.22 51 541766 14877 50048430
Hepatic necrosis 50.57 10.22 147 541670 5101 50058206
Flushing 50.55 10.22 1003 540814 66012 49997295
Respiratory disorder 50.20 10.22 533 541284 30654 50032653
Disease progression 50.15 10.22 723 541094 95143 49968164
General physical health deterioration 50 10.22 1152 540665 141282 49922025
Red blood cells urine positive 49.87 10.22 99 541718 2676 50060631
Diarrhoea 49.74 10.22 5530 536287 582946 49480361
Blood calcium decreased 49.22 10.22 385 541432 20321 50042986
Back pain 49.16 10.22 2852 538965 217178 49846129
Cardiac failure congestive 48.97 10.22 623 541194 83759 49979548
Creatinine renal clearance decreased 48.87 10.22 254 541563 11627 50051680
Infusion site pruritus 48.75 10.22 121 541696 3816 50059491
Lymphocyte count decreased 47.82 10.22 461 541356 25846 50037461
Hypocalcaemia 47.30 10.22 139 541678 26677 50036630
Hypokalaemia 47.30 10.22 660 541157 87332 49975975
Haematotoxicity 47.20 10.22 13 541804 7882 50055425
Pyroglutamate increased 45.48 10.22 37 541780 383 50062924
Granuloma skin 44.68 10.22 5 541812 5813 50057494
Red cell distribution width increased 44.66 10.22 196 541621 8363 50054944
Pneumocystis jirovecii pneumonia 44.32 10.22 55 541762 14608 50048699
Hepatic failure 43.96 10.22 534 541283 31749 50031558
Myocardial infarction 43.27 10.22 681 541136 88346 49974961
Swelling 42.83 10.22 2593 539224 198279 49865028
Crystal urine present 42.79 10.22 65 541752 1409 50061898
Renal impairment 42.29 10.22 563 541254 75098 49988209
Hepatocellular injury 41.89 10.22 140 541677 25807 50037500
Contusion 41.74 10.22 1531 540286 110652 49952655
Ear pruritus 41.70 10.22 87 541730 2439 50060868
Infection 41.57 10.22 2257 539560 170697 49892610
Intentional self-injury 41.35 10.22 119 541698 22993 50040314
Therapeutic product effect incomplete 40.87 10.22 711 541106 90804 49972503
Foetal exposure during pregnancy 40.57 10.22 153 541664 27206 50036101
Myelodysplastic syndrome 40.47 10.22 62 541755 15070 50048237
Fracture 40.37 10.22 74 541743 16759 50046548
Temperature regulation disorder 40.34 10.22 118 541699 4109 50059198
Blood urine present 40.10 10.22 255 541562 12578 50050729
Agranulocytosis 40.03 10.22 108 541709 21313 50041994
Panniculitis 39.24 10.22 21 541796 8482 50054825
Palmar-plantar erythrodysaesthesia syndrome 38.56 10.22 100 541717 19998 50043309
Therapy cessation 38.23 10.22 146 541671 25865 50037442
Diabetic ketoacidosis 38.21 10.22 84 541733 17788 50045519
Pyroglutamic acidosis 37.71 10.22 34 541783 409 50062898
Chest discomfort 37.36 10.22 1277 540540 91445 49971862
Arthralgia 37.36 10.22 5299 536518 433403 49629904
Suicidal ideation 36.73 10.22 397 541420 54988 50008319
Febrile bone marrow aplasia 36.61 10.22 11 541806 6300 50057007
Product substitution issue 36.26 10.22 59 541758 13998 50049309
Body temperature fluctuation 36.20 10.22 71 541746 1902 50061405
Heart rate irregular 36.05 10.22 341 541476 19019 50044288
Bursitis 35.95 10.22 379 541438 21756 50041551
Transplant rejection 35.92 10.22 30 541787 9579 50053728
Psoriatic arthropathy 35.84 10.22 326 541491 46706 50016601
Decreased appetite 35.72 10.22 1772 540045 199151 49864156
Off label use 35.45 10.22 4494 537323 469932 49593375
Electric shock 35.18 10.22 49 541768 979 50062328
Chills 35.12 10.22 1316 540501 95371 49967936
Therapeutic response decreased 34.87 10.22 330 541487 46901 50016406
Exposure via ingestion 34.55 10.22 86 541731 2717 50060590
Drug eruption 34.37 10.22 133 541684 23473 50039834
Unintentional medical device removal 34.32 10.22 8 541809 5427 50057880
Neoplasm progression 34.20 10.22 178 541639 28979 50034328
Electrocardiogram QT prolonged 33.98 10.22 373 541444 51513 50011794
Urine analysis abnormal 33.74 10.22 113 541704 4237 50059070
Accidental exposure to product 33.51 10.22 130 541687 22927 50040380
Rheumatoid nodule 33.28 10.22 53 541764 12682 50050625
Injection site warmth 33.21 10.22 61 541756 13805 50049502
Product storage error 32.77 10.22 50 541767 12174 50051133
Diabetes mellitus 32.71 10.22 351 541466 48682 50014625
No adverse event 32.48 10.22 218 541599 33360 50029947
Respiratory rate increased 32.40 10.22 221 541596 11164 50052143
Inappropriate antidiuretic hormone secretion 32.21 10.22 57 541760 13086 50050221
Anion gap abnormal 32.13 10.22 28 541789 321 50062986
Fatigue 32.10 10.22 8279 533538 699322 49363985
Injection site haemorrhage 31.90 10.22 119 541698 21227 50042080
Hypercalcaemia 31.84 10.22 135 541682 23217 50040090
Condition aggravated 31.76 10.22 2743 539074 294315 49768992
Culture urine positive 31.66 10.22 95 541722 3356 50059951
Akathisia 31.62 10.22 25 541792 8204 50055103
Cardio-respiratory arrest 31.57 10.22 778 541039 53114 50010193
Device malfunction 31.56 10.22 72 541745 15049 50048258
Skin necrosis 31.56 10.22 42 541775 10825 50052482
Polyneuropathy 31.21 10.22 51 541766 12080 50051227
Pathogen resistance 31.09 10.22 11 541806 5678 50057629
Device dislocation 30.98 10.22 122 541695 21424 50041883
Administration site pain 30.96 10.22 37 541780 631 50062676
Drug reaction with eosinophilia and systemic symptoms 30.88 10.22 178 541639 28246 50035061
Cognitive disorder 30.83 10.22 653 541164 43470 50019837
Poor venous access 30.80 10.22 203 541614 10137 50053170
Metastases to liver 30.75 10.22 111 541706 19993 50043314
Maternal exposure during pregnancy 30.59 10.22 1398 540419 158380 49904927
Suspected suicide 30.52 10.22 126 541691 5231 50058076
Osteonecrosis 30.19 10.22 131 541686 22386 50040921
Food allergy 30.11 10.22 169 541648 7968 50055339
Haemophagocytic lymphohistiocytosis 29.82 10.22 29 541788 8604 50054703
Surgery 29.77 10.22 195 541622 30010 50033297
Hypertensive crisis 29.65 10.22 60 541757 13094 50050213
Lymphocyte percentage decreased 29.23 10.22 80 541737 2680 50060627
Seizure 29.14 10.22 1001 540816 116873 49946434
Incorrect drug administration rate 29.07 10.22 77 541740 2529 50060778
Post transplant lymphoproliferative disorder 29.03 10.22 5 541812 4199 50059108
Discomfort 29.00 10.22 1429 540388 106951 49956356
Blood pH decreased 28.88 10.22 74 541743 2381 50060926
Accidental overdose 28.76 10.22 328 541489 19205 50044102
Oedema peripheral 28.67 10.22 1390 540427 156571 49906736
Cerebrovascular accident 28.56 10.22 783 541034 93897 49969410
Poisoning 28.39 10.22 229 541588 12200 50051107
Rhabdomyolysis 28.24 10.22 274 541543 38753 50024554
Renal failure 27.90 10.22 899 540918 105734 49957573
Infusion site bruising 27.86 10.22 70 541747 2225 50061082
Genital haemorrhage 27.84 10.22 18 541799 6556 50056751
Infusion site nodule 27.63 10.22 46 541771 1081 50062226
Thrombotic microangiopathy 27.60 10.22 32 541785 8759 50054548
Transplant dysfunction 27.47 10.22 8 541809 4676 50058631
Device use error 27.41 10.22 11 541806 5255 50058052
Administration site swelling 27.38 10.22 44 541773 1003 50062304
Femur fracture 27.12 10.22 263 541554 37201 50026106
Urine ketone body present 27.11 10.22 70 541747 2263 50061044
Gestational diabetes 27.06 10.22 24 541793 7441 50055866
Body temperature decreased 26.76 10.22 281 541536 16114 50047193
Cardiac arrest 26.74 10.22 1123 540694 82528 49980779
Galactorrhoea 26.67 10.22 4 541813 3719 50059588
Prothrombin time prolonged 26.62 10.22 174 541643 8664 50054643
Therapeutic response shortened 26.38 10.22 152 541665 7237 50056070
Injection site rash 26.31 10.22 87 541730 16090 50047217
Hyperglycaemia 26.17 10.22 256 541561 36149 50027158
Malaise 26.17 10.22 3169 538648 332363 49730944
Pain 25.91 10.22 6770 535047 572133 49491174
Device issue 25.69 10.22 118 541699 19854 50043453
Confusional state 25.64 10.22 2318 539499 183610 49879697
Disease recurrence 25.62 10.22 119 541698 19962 50043345
Cerebral haemorrhage 25.48 10.22 177 541640 26875 50036432
Bacterial test 25.44 10.22 45 541772 1112 50062195
Injury 25.37 10.22 695 541122 48230 50015077
Second primary malignancy 25.34 10.22 22 541795 6892 50056415
Blood magnesium increased 25.23 10.22 78 541739 2802 50060505
Metastases to lung 25.07 10.22 50 541767 10970 50052337
Hallucination, auditory 24.99 10.22 48 541769 10680 50052627
Acute graft versus host disease 24.65 10.22 6 541811 3952 50059355
Treatment failure 24.61 10.22 1213 540604 136424 49926883
Metastases to bone 24.55 10.22 104 541713 17891 50045416
Oropharyngeal pain 24.31 10.22 1042 540775 76759 49986548
Cerebral infarction 24.17 10.22 134 541683 21470 50041837
Haemoglobin urine present 24.05 10.22 36 541781 770 50062537
Hypotension 24.00 10.22 2876 538941 232593 49830714
Peptic ulcer haemorrhage 23.90 10.22 41 541776 988 50062319
Upper respiratory tract infection 23.69 10.22 896 540921 65002 49998305
Drug withdrawal syndrome 23.68 10.22 164 541653 24917 50038390
Hypomagnesaemia 23.58 10.22 148 541669 23008 50040299
Angioedema 23.43 10.22 274 541543 37402 50025905
Neutrophil percentage increased 23.10 10.22 73 541744 2654 50060653
Therapy interrupted 23.09 10.22 124 541693 20028 50043279
Erysipelas 23.05 10.22 22 541795 6586 50056721
Specific gravity urine decreased 22.41 10.22 32 541785 655 50062652
Pleural thickening 22.40 10.22 70 541747 2529 50060778
Basal cell carcinoma 22.40 10.22 152 541665 23204 50040103
Fall 22.40 10.22 3194 538623 331738 49731569
Brain death 22.21 10.22 73 541744 2710 50060597
Pleural fibrosis 22.03 10.22 83 541734 3301 50060006
Analgesic drug level above therapeutic 22.02 10.22 17 541800 162 50063145
Injection site induration 21.89 10.22 35 541782 8362 50054945
Anion gap increased 21.74 10.22 49 541768 1450 50061857
Neuroleptic malignant syndrome 21.65 10.22 55 541762 11075 50052232
Multiple organ dysfunction syndrome 21.54 10.22 394 541423 49943 50013364
Intervertebral discitis 21.50 10.22 70 541747 2586 50060721
Presbyacusis 21.43 10.22 72 541745 2704 50060603
Tardive dyskinesia 21.27 10.22 28 541789 7251 50056056
Synovitis 21.21 10.22 1570 540247 122295 49941012
Lymphopenia 20.87 10.22 91 541726 15530 50047777
Blood iron abnormal 20.80 10.22 5 541812 3321 50059986
Maternal exposure during delivery 20.68 10.22 38 541779 968 50062339
Infusion site haemorrhage 20.67 10.22 75 541742 2929 50060378
Methaemoglobinaemia 20.45 10.22 58 541759 1984 50061323
Epstein-Barr virus infection 20.36 10.22 27 541790 6970 50056337
Injection site urticaria 20.35 10.22 65 541752 12152 50051155
Ascites 20.34 10.22 266 541551 35595 50027712
Musculoskeletal disorder 20.30 10.22 106 541711 17243 50046064
Anaesthetic complication 20.20 10.22 52 541765 1678 50061629
Pyrexia 20.17 10.22 4481 537336 375722 49687585
Syncope 20.15 10.22 899 540918 102103 49961204
Bacterial test positive 20.14 10.22 102 541715 4621 50058686
Corneal oedema 19.74 10.22 45 541772 1342 50061965
Femoral neck fracture 19.73 10.22 31 541786 7459 50055848
Anterior spinal artery syndrome 19.73 10.22 12 541805 74 50063233
Brain oedema 19.71 10.22 211 541606 12159 50051148
Peripheral sensory neuropathy 19.63 10.22 25 541792 6566 50056741
Dyskinesia 19.58 10.22 197 541620 27664 50035643
Bronchopulmonary aspergillosis 19.46 10.22 32 541785 7560 50055747
Soft tissue disorder 19.39 10.22 93 541724 4121 50059186
Infusion site urticaria 19.35 10.22 37 541780 972 50062335
Product use in unapproved indication 19.30 10.22 1028 540789 114791 49948516
Treatment noncompliance 19.24 10.22 218 541599 29932 50033375
Mania 18.95 10.22 57 541760 10859 50052448
Bone erosion 18.90 10.22 63 541754 11624 50051683
Insomnia 18.90 10.22 2144 539673 172721 49890586
Altered state of consciousness 18.89 10.22 147 541670 21763 50041544
Acute myeloid leukaemia 18.84 10.22 90 541727 14984 50048323
Neuropathy peripheral 18.83 10.22 845 540972 95912 49967395
Pneumonia aspiration 18.69 10.22 227 541590 30777 50032530
Therapy non-responder 18.64 10.22 410 541407 50612 50012695
Hepatic cirrhosis 18.60 10.22 111 541706 17466 50045841
Breast cancer 18.57 10.22 335 541482 42555 50020752
Gastrointestinal haemorrhage 18.50 10.22 621 541196 72700 49990607
Platelet count decreased 17.94 10.22 888 540929 99838 49963469
Disturbance in attention 17.80 10.22 231 541586 30955 50032352
Graft versus host disease 17.74 10.22 24 541793 6142 50057165
Coeliac disease 17.70 10.22 156 541661 8529 50054778
Device difficult to use 17.61 10.22 51 541766 9835 50053472
Skin toxicity 17.57 10.22 10 541807 3903 50059404
Blood creatinine decreased 17.53 10.22 102 541715 4874 50058433
Labelled drug-drug interaction medication error 17.27 10.22 56 541761 10421 50052886
Skin ulcer 17.20 10.22 270 541547 35048 50028259
Multiple-drug resistance 17.12 10.22 7 541810 3307 50060000
Ejection fraction decreased 17.04 10.22 122 541695 18398 50044909
Eosinophil percentage increased 17.00 10.22 34 541783 924 50062383
Sexual dysfunction 16.93 10.22 7 541810 3285 50060022
Peritonitis 16.81 10.22 97 541720 15389 50047918
Eyelid rash 16.75 10.22 11 541806 79 50063228
Epigastric discomfort 16.73 10.22 114 541703 5756 50057551
Metastases to lymph nodes 16.73 10.22 31 541786 6993 50056314
Hypoglycaemia 16.70 10.22 441 541376 53140 50010167
Chronic graft versus host disease 16.62 10.22 5 541812 2862 50060445
Hypertransaminasaemia 16.54 10.22 9 541808 3602 50059705
Disorientation 16.38 10.22 274 541543 35210 50028097
Infusion site rash 16.36 10.22 41 541776 1301 50062006
Lupus vasculitis 16.35 10.22 23 541794 464 50062843
Rash pruritic 16.20 10.22 389 541428 47457 50015850
Substance abuse 16.16 10.22 87 541730 4037 50059270
Human herpesvirus 6 infection 16.13 10.22 4 541813 2602 50060705
Sputum culture positive 16.00 10.22 42 541775 1372 50061935
Immunodeficiency 15.93 10.22 235 541582 14593 50048714
Dysarthria 15.93 10.22 293 541524 37110 50026197
Hepatic function abnormal 15.87 10.22 250 541567 32431 50030876
Paraesthesia 15.68 10.22 1092 540725 119151 49944156
Graft versus host disease in skin 15.68 10.22 4 541813 2552 50060755
Pancreatitis acute 15.66 10.22 171 541646 23641 50039666
Multiple drug therapy 15.63 10.22 51 541766 1886 50061421
PO2 increased 15.59 10.22 30 541787 792 50062515
Concussion 15.54 10.22 137 541680 7491 50055816
Aspergillus infection 15.47 10.22 31 541786 6790 50056517
Infusion site discomfort 15.39 10.22 31 541786 847 50062460
Atypical femur fracture 15.32 10.22 18 541799 4898 50058409
Lip pruritus 15.19 10.22 28 541789 715 50062592
Infusion site mass 15.15 10.22 37 541780 1155 50062152
Dermatitis bullous 15.10 10.22 34 541783 7139 50056168
Chronic sinusitis 15.01 10.22 115 541702 6030 50057277
Vital capacity decreased 14.71 10.22 32 541785 924 50062383
Administration site erythema 14.70 10.22 23 541794 512 50062795
Ischaemic stroke 14.70 10.22 105 541712 15843 50047464
Wound 14.57 10.22 1319 540498 104475 49958832
Hyperprolactinaemia 14.55 10.22 9 541808 3356 50059951
Cytomegalovirus infection reactivation 14.53 10.22 5 541812 2626 50060681
Haematuria 14.52 10.22 190 541627 25423 50037884
Liver transplant 14.47 10.22 53 541764 2079 50061228
Enthesopathy 14.41 10.22 35 541782 7158 50056149
Migraine 14.41 10.22 963 540854 74317 49988990
Underdose 14.41 10.22 143 541674 20135 50043172
Congestive cardiomyopathy 14.38 10.22 23 541794 5495 50057812
Ear infection 14.34 10.22 372 541445 25598 50037709
Febrile neutropenia 14.26 10.22 878 540939 96789 49966518
Amenorrhoea 14.23 10.22 45 541772 8439 50054868
Blood methaemoglobin present 14.12 10.22 9 541808 61 50063246
Vein collapse 14.07 10.22 25 541792 620 50062687
Pneumocephalus 14.02 10.22 12 541805 134 50063173
Product monitoring error 14.02 10.22 6 541811 2758 50060549
Torsade de pointes 14.02 10.22 72 541745 11763 50051544
Pancreatitis 14.01 10.22 348 541469 42266 50021041
Rhythm idioventricular 13.93 10.22 13 541804 164 50063143
Liver disorder 13.91 10.22 298 541519 36924 50026383
Cytomegalovirus viraemia 13.88 10.22 18 541799 4691 50058616
COVID-19 immunisation 13.87 10.22 27 541790 719 50062588
Product tampering 13.85 10.22 14 541803 196 50063111
Specific gravity urine increased 13.85 10.22 14 541803 196 50063111
Spinal meningioma benign 13.82 10.22 11 541806 110 50063197
Metastases to central nervous system 13.73 10.22 68 541749 11214 50052093
Arrhythmia 13.66 10.22 261 541556 32871 50030436
Bone pain 13.62 10.22 393 541424 46836 50016471
Fear of injection 13.62 10.22 28 541789 6075 50057232
Liver injury 13.61 10.22 355 541462 24451 50038856
Cestode infection 13.47 10.22 16 541801 271 50063036
Cardiotoxicity 13.45 10.22 35 541782 6992 50056315
Coagulation factor VII level decreased 13.44 10.22 9 541808 67 50063240
Respiratory failure 13.43 10.22 819 540998 90362 49972945
Ductus arteriosus premature closure 13.41 10.22 17 541800 309 50062998
Toxicologic test abnormal 13.40 10.22 24 541793 599 50062708
Withdrawal syndrome 13.37 10.22 122 541695 17468 50045839
Injection site haematoma 13.35 10.22 28 541789 6032 50057275
Infusion site irritation 13.34 10.22 24 541793 601 50062706
Hypersensitivity vasculitis 13.28 10.22 14 541803 4001 50059306
Systemic infection 13.20 10.22 4 541813 2279 50061028
Nephropathy toxic 13.18 10.22 43 541774 7986 50055321
Lagophthalmos 13.16 10.22 16 541801 278 50063029
Psychomotor skills impaired 13.11 10.22 3 541814 2061 50061246
Gastroenteritis 13.09 10.22 173 541644 23108 50040199
Bradyphrenia 13.08 10.22 29 541788 6123 50057184
Blood uric acid decreased 13.07 10.22 25 541792 657 50062650
Right ventricular failure 13.07 10.22 108 541709 15785 50047522
Small for dates baby 13.03 10.22 11 541806 3494 50059813
Hand deformity 13.01 10.22 1244 540573 98955 49964352
Osmolar gap 12.98 10.22 10 541807 95 50063212
Pulmonary tuberculosis 12.94 10.22 16 541801 4257 50059050
Monocyte percentage increased 12.90 10.22 32 541785 1009 50062298
Glycosylated haemoglobin increased 12.86 10.22 64 541753 10542 50052765
Lupus-like syndrome 12.86 10.22 55 541762 9436 50053871
Procedural hypotension 12.74 10.22 33 541784 1069 50062238
Hepatitis B 12.73 10.22 11 541806 3455 50059852
Stillbirth 12.70 10.22 28 541789 5924 50057383
Foetal growth restriction 12.69 10.22 33 541784 6594 50056713
Haematoma 12.68 10.22 240 541577 30270 50033037
Bone cyst 12.65 10.22 49 541768 1975 50061332
Neuralgia 12.61 10.22 315 541502 21548 50041759
Rash maculo-papular 12.53 10.22 205 541612 26436 50036871
Aphasia 12.51 10.22 222 541595 28272 50035035
Personality change 12.51 10.22 26 541791 5619 50057688
Hepatocellular carcinoma 12.51 10.22 3 541814 1996 50061311
Haematemesis 12.50 10.22 215 541602 27510 50035797
Dizziness 12.43 10.22 3410 538407 342959 49720348
Loss of consciousness 12.43 10.22 955 540862 103398 49959909
Band neutrophil count increased 12.42 10.22 17 541800 334 50062973
Injection site discolouration 12.41 10.22 36 541781 6938 50056369
Nerve block 12.38 10.22 20 541797 458 50062849
Sepsis 12.36 10.22 1240 540577 131685 49931622
Nerve root injury 12.36 10.22 7 541810 37 50063270
Immunosuppressant drug level increased 12.31 10.22 9 541808 3073 50060234
Abnormal dreams 12.30 10.22 55 541762 9322 50053985
Constipation 12.29 10.22 2213 539604 183495 49879812
Smear cervix abnormal 12.26 10.22 60 541757 2681 50060626
Nephrogenic systemic fibrosis 12.25 10.22 17 541800 4305 50059002
Injection site mass 12.24 10.22 108 541709 15572 50047735
Proteinuria 12.23 10.22 116 541701 16481 50046826
Neurotoxicity 12.19 10.22 100 541717 14640 50048667
Administration site bruise 12.19 10.22 15 541802 264 50063043
International normalised ratio increased 12.17 10.22 572 541245 42580 50020727
Cardiovascular disorder 12.16 10.22 64 541753 10390 50052917
Abortion induced 12.14 10.22 55 541762 9289 50054018
Balance disorder 12.12 10.22 895 540922 69695 49993612
Orthostatic hypotension 12.11 10.22 407 541410 29074 50034233
Caesarean section 12.09 10.22 108 541709 15531 50047776
Dehydration 12.08 10.22 1438 540379 151011 49912296
Atonic urinary bladder 12.07 10.22 9 541808 81 50063226
Allergy to immunoglobulin therapy 12.04 10.22 5 541812 11 50063296
Nightmare 12.04 10.22 112 541705 15974 50047333
C-reactive protein increased 12.03 10.22 585 541232 65889 49997418
Partial seizures 12.01 10.22 21 541796 4844 50058463
Atelectasis 12.00 10.22 268 541549 18002 50045305
Renal ischaemia 11.98 10.22 22 541795 560 50062747
Drug dose omission by device 11.97 10.22 7 541810 2692 50060615
Acute myocardial infarction 11.94 10.22 231 541586 29042 50034265
Product residue present 11.93 10.22 13 541804 3659 50059648
Weight fluctuation 11.90 10.22 123 541694 7025 50056282
Coagulation factor X level decreased 11.80 10.22 8 541809 61 50063246
Administration site reaction 11.76 10.22 13 541804 203 50063104
Anaphylactic reaction 11.72 10.22 699 541118 53356 50009951
Mean cell haemoglobin concentration decreased 11.67 10.22 61 541756 2798 50060509
Mean arterial pressure decreased 11.65 10.22 11 541806 141 50063166
Pregnancy with contraceptive device 11.61 10.22 16 541801 4063 50059244
Renal failure neonatal 11.60 10.22 12 541805 173 50063134
Jaundice cholestatic 11.58 10.22 94 541723 5017 50058290
Feeling hot 11.57 10.22 522 541295 38680 50024627
Tenosynovitis 11.56 10.22 66 541751 10499 50052808
Infusion site haematoma 11.53 10.22 14 541803 243 50063064
Rheumatoid lung 11.51 10.22 6 541811 2459 50060848
Bronchial secretion retention 11.47 10.22 39 541778 1474 50061833
Cholestasis 11.44 10.22 197 541620 25204 50038103
Post procedural pulmonary embolism 11.44 10.22 14 541803 245 50063062
Sedation 11.43 10.22 418 541399 30192 50033115
Adverse event 11.43 10.22 369 541448 43394 50019913
Neovascularisation 11.37 10.22 30 541787 983 50062324
Ketoacidosis 11.37 10.22 15 541802 3880 50059427
Acidosis 11.35 10.22 163 541654 10064 50053243
Catatonia 11.30 10.22 14 541803 3722 50059585
Leukoencephalopathy 11.28 10.22 15 541802 3868 50059439
Renal tubular disorder 11.27 10.22 6 541811 2431 50060876
Pulse absent 11.22 10.22 89 541728 4717 50058590
Depression 11.20 10.22 1576 540241 163847 49899460
Hemiplegia 11.12 10.22 41 541776 7340 50055967
White blood cells urine 11.11 10.22 16 541801 330 50062977
Breast cancer female 11.09 10.22 37 541780 6825 50056482
Ovarian hyperstimulation syndrome 11.09 10.22 11 541806 3233 50060074
Renal papillary necrosis 11.05 10.22 13 541804 218 50063089
Aqueous fibrin 11.01 10.22 8 541809 69 50063238
Nail bed inflammation 10.98 10.22 17 541800 375 50062932
Nitrite urine present 10.97 10.22 28 541789 899 50062408
Epistaxis 10.96 10.22 566 541251 63388 49999919
Immune reconstitution inflammatory syndrome 10.93 10.22 27 541790 5489 50057818
Concomitant disease aggravated 10.89 10.22 47 541770 8044 50055263
Nasal congestion 10.89 10.22 660 541157 50460 50012847
JC virus infection 10.83 10.22 3 541814 1812 50061495
Nausea 10.80 10.22 7155 534662 698243 49365064
Meningitis chemical 10.79 10.22 10 541807 125 50063182
Transfusion-related acute lung injury 10.77 10.22 9 541808 97 50063210
Dystonia 10.76 10.22 79 541738 11847 50051460
Haemorrhage 10.74 10.22 465 541352 52976 50010331
Lymphoproliferative disorder 10.73 10.22 9 541808 2868 50060439
Haemolysis 10.72 10.22 105 541712 5911 50057396
PCO2 decreased 10.65 10.22 33 541784 1187 50062120
Central venous pressure decreased 10.64 10.22 3 541814 0 50063307
Carotid pulse decreased 10.64 10.22 3 541814 0 50063307
Oxygen saturation abnormal 10.59 10.22 57 541760 2645 50060662
Acute graft versus host disease in skin 10.59 10.22 10 541807 3008 50060299
Aplasia pure red cell 10.59 10.22 18 541799 4197 50059110
Administration site pruritus 10.57 10.22 14 541803 266 50063041
Affective disorder 10.55 10.22 25 541792 5156 50058151
Gamma-glutamyltransferase increased 10.54 10.22 239 541578 29384 50033923
Abdominal discomfort 10.49 10.22 2256 539561 229385 49833922
Eye infection 10.47 10.22 150 541667 9256 50054051
Cardiac failure acute 10.46 10.22 49 541768 8201 50055106
Obesity 10.43 10.22 122 541695 16653 50046654
Toxic skin eruption 10.41 10.22 74 541743 11177 50052130
Illness 10.39 10.22 340 541477 24200 50039107
Systemic lupus erythematosus 10.32 10.22 1333 540484 139289 49924018
Skin infection 10.31 10.22 187 541630 12104 50051203
Tri-iodothyronine free increased 10.30 10.22 12 541805 199 50063108
Brain stem glioma 10.30 10.22 10 541807 133 50063174
Hyperammonaemia 10.27 10.22 22 541795 4702 50058605
Extradural abscess 10.26 10.22 25 541792 779 50062528
Reversible airways obstruction 10.24 10.22 29 541788 991 50062316

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 583.05 10.65 1835 238678 88411 29245603
Infusion related reaction 573.85 10.65 1167 239346 42719 29291295
Toxicity to various agents 485.24 10.65 2730 237783 170931 29163083
Blood pressure fluctuation 269.33 10.65 537 239976 19357 29314657
Exposure to toxic agent 221.79 10.65 177 240336 2398 29331616
Drug interaction 190.19 10.65 892 239621 196493 29137521
Acute hepatic failure 185.58 10.65 342 240171 11610 29322404
Overdose 171.95 10.65 1175 239338 78644 29255370
Heart rate decreased 161.78 10.65 508 240005 24404 29309610
Blood pressure increased 150.45 10.65 1072 239441 72731 29261283
Chills 143.21 10.65 1032 239481 70268 29263746
Intentional product misuse 132.35 10.65 596 239917 34065 29299949
Drug resistance 101.55 10.65 25 240488 21515 29312499
Drug ineffective 98.84 10.65 2227 238286 360943 28973071
Oxygen saturation decreased 98.15 10.65 664 239849 44273 29289741
Sinusitis 98.06 10.65 544 239969 33806 29300208
Intentional overdose 97.52 10.65 591 239922 37937 29296077
Cardiac failure 93.96 10.65 330 240183 78957 29255057
Methaemoglobinaemia 90.18 10.65 110 240403 2561 29331453
Blood pressure diastolic abnormal 82.81 10.65 103 240410 2448 29331566
Myocardial infarction 76.75 10.65 553 239960 109743 29224271
Anaphylactic reaction 76.26 10.65 433 240080 27140 29306874
Interstitial lung disease 71.92 10.65 235 240278 57483 29276531
Anaemia 69.41 10.65 1183 239330 199768 29134246
Anion gap 64.26 10.65 51 240462 685 29333329
Accidental overdose 62.31 10.65 296 240217 17297 29316717
Sopor 61.67 10.65 8 240505 10926 29323088
General physical health deterioration 61.67 10.65 537 239976 102320 29231694
Bone marrow failure 61.18 10.65 80 240433 27369 29306645
Blood pressure systolic abnormal 60.35 10.65 81 240432 2080 29331934
Urticaria 60.26 10.65 695 239818 53965 29280049
Blood pressure systolic increased 60.09 10.65 284 240229 16561 29317453
Respiratory arrest 59.57 10.65 387 240126 25446 29308568
Coagulopathy 56.82 10.65 292 240221 17615 29316399
Heart rate increased 56.17 10.65 523 239990 38415 29295599
Hypotension 56.01 10.65 2018 238495 192336 29141678
Anaesthetic complication 55.12 10.65 53 240460 933 29333081
Foetal exposure during pregnancy 54.95 10.65 121 240392 33746 29300268
Metabolic acidosis 54.39 10.65 506 240007 37156 29296858
Treatment failure 54.34 10.65 139 240374 36800 29297214
Flushing 53.24 10.65 411 240102 28581 29305433
Back pain 51.63 10.65 1141 239372 101143 29232871
Infusion site extravasation 50.46 10.65 91 240422 3036 29330978
Diarrhoea 49.59 10.65 2207 238306 330491 29003523
Acute kidney injury 48.75 10.65 1717 238796 263550 29070464
Toxic anterior segment syndrome 45.70 10.65 49 240464 987 29333027
Renal impairment 44.67 10.65 434 240079 80899 29253115
Cardiac failure congestive 44.48 10.65 403 240110 76178 29257836
Respiratory depression 43.24 10.65 221 240292 13302 29320712
Blood pressure diastolic increased 42.28 10.65 93 240420 3593 29330421
Leukopenia 42.23 10.65 269 240244 54934 29279080
Diabetes mellitus 41.84 10.65 174 240339 39657 29294357
Cerebral infarction 41.83 10.65 86 240427 24589 29309425
Unresponsive to stimuli 41.14 10.65 347 240166 24779 29309235
Hepatic cytolysis 40.88 10.65 155 240358 8192 29325822
Contraindicated product administered 39.92 10.65 54 240459 18212 29315802
Cytomegalovirus infection 39.28 10.65 81 240432 23134 29310880
Infusion site swelling 38.95 10.65 61 240452 1809 29332205
Hyperkalaemia 38.80 10.65 316 240197 61076 29272938
Pain 38.22 10.65 1732 238781 169700 29164314
Hepatic necrosis 37.98 10.65 87 240426 3455 29330559
Heart rate irregular 37.59 10.65 208 240305 12909 29321105
Haematotoxicity 37.54 10.65 5 240508 6694 29327320
Body temperature decreased 37.46 10.65 179 240334 10485 29323529
Substance abuse 37.43 10.65 131 240382 6656 29327358
Myelosuppression 37.25 10.65 27 240486 12200 29321814
Malignant neoplasm progression 36.11 10.65 405 240108 73454 29260560
Intentional product use issue 36.08 10.65 515 239998 41983 29292031
Product prescribing error 35.52 10.65 57 240456 17919 29316095
Rhabdomyolysis 35.30 10.65 320 240193 60488 29273526
Throat tightness 34.99 10.65 132 240381 6959 29327055
Immune reconstitution inflammatory syndrome 34.98 10.65 10 240503 7792 29326222
Infusion site pruritus 34.93 10.65 31 240482 490 29333524
Infusion site pain 33.78 10.65 74 240439 2851 29331163
Renal injury 33.51 10.65 168 240345 10034 29323980
Hepatotoxicity 33.19 10.65 254 240259 17613 29316401
Anhedonia 33.05 10.65 131 240382 7069 29326945
Throat irritation 32.72 10.65 150 240363 8635 29325379
Therapeutic product effect incomplete 32.43 10.65 187 240326 39118 29294896
Labelled drug-drug interaction medication error 31.93 10.65 31 240482 12128 29321886
Body temperature increased 31.71 10.65 214 240299 14251 29319763
Pancytopenia 31.49 10.65 481 240032 82687 29251327
Progressive multifocal leukoencephalopathy 31.09 10.65 16 240497 8703 29325311
Cerebral haemorrhage 30.74 10.65 141 240372 31285 29302729
Ear infection 30.68 10.65 139 240374 7961 29326053
Liver injury 30.42 10.65 192 240321 12498 29321516
Fear 30.16 10.65 155 240358 9349 29324665
Local anaesthetic systemic toxicity 29.77 10.65 19 240494 176 29333838
Graft versus host disease 29.67 10.65 21 240492 9607 29324407
Mucosal inflammation 29.59 10.65 144 240369 31451 29302563
Accidental exposure to product by child 29.36 10.65 45 240468 1309 29332705
Septic shock 29.04 10.65 347 240166 62213 29271801
Nasopharyngitis 28.63 10.65 661 239852 59004 29275010
Psoriasis 28.41 10.65 150 240363 32077 29301937
Hepatocellular injury 28.20 10.65 84 240429 21159 29312855
Analgesic drug level increased 27.89 10.65 29 240484 563 29333451
Emotional distress 27.78 10.65 201 240312 13694 29320320
Product dose omission issue 27.75 10.65 585 239928 95798 29238216
Medication error 26.72 10.65 277 240236 20934 29313080
Coronary artery disease 26.32 10.65 231 240282 43959 29290055
Wrong technique in product usage process 26.21 10.65 149 240364 31279 29302735
Angina pectoris 26.04 10.65 127 240386 27723 29306291
Pyroglutamic acidosis 25.80 10.65 20 240493 259 29333755
Venoocclusive liver disease 25.72 10.65 12 240501 6905 29327109
Respiratory rate increased 25.57 10.65 139 240374 8569 29325445
Cardio-respiratory arrest 25.03 10.65 563 239950 50038 29283976
Hypoxia 24.98 10.65 532 239981 46847 29287167
Headache 24.93 10.65 1688 238825 172319 29161695
Post transplant lymphoproliferative disorder 24.70 10.65 7 240506 5486 29328528
Rheumatoid arthritis 24.70 10.65 383 240130 31769 29302245
Product use in unapproved indication 24.51 10.65 529 239984 86346 29247668
Renal cortical necrosis 24.39 10.65 16 240497 156 29333858
Tachycardia 24.38 10.65 766 239747 71644 29262370
Melaena 24.31 10.65 151 240362 31025 29302989
Injury 24.12 10.65 249 240264 18797 29315217
Neutrophil percentage increased 24.00 10.65 48 240465 1733 29332281
Glycosylated haemoglobin increased 23.65 10.65 25 240488 9401 29324613
Parkinsonism 23.60 10.65 15 240498 7263 29326751
Stress 23.55 10.65 273 240240 21217 29312797
Lactic acidosis 23.32 10.65 147 240366 30100 29303914
Thrombocytopenia 23.25 10.65 879 239634 133944 29200070
Cytokine release syndrome 22.98 10.65 184 240329 12935 29321079
Neutropenia 22.87 10.65 858 239655 130853 29203161
Extrapyramidal disorder 22.69 10.65 33 240480 10798 29323216
Hypomagnesaemia 22.53 10.65 70 240443 17398 29316616
Blood pH decreased 22.44 10.65 52 240461 2081 29331933
Poor venous access 21.94 10.65 66 240447 3095 29330919
Electrocardiogram QT prolonged 21.92 10.65 188 240325 35949 29298065
Pancreatitis acute 21.77 10.65 113 240400 24272 29309742
Hypoglycaemia 21.73 10.65 270 240243 48076 29285938
Suspected suicide 21.66 10.65 77 240436 3943 29330071
Multiple-drug resistance 21.64 10.65 3 240510 3897 29330117
Bronchospasm 21.57 10.65 143 240370 9466 29324548
Loss of personal independence in daily activities 21.54 10.65 120 240393 25320 29308694
Blood pressure diastolic decreased 21.23 10.65 113 240400 6909 29327105
Cardiac arrest 21.09 10.65 874 239639 84717 29249297
Therapeutic response shortened 21.06 10.65 86 240427 4705 29329309
Pulmonary function test decreased 20.96 10.65 78 240435 4085 29329929
Epilepsy 20.96 10.65 78 240435 18354 29315660
C-reactive protein increased 20.73 10.65 245 240268 44018 29289996
Osteonecrosis 20.55 10.65 50 240463 13469 29320545
Hepatic function abnormal 20.49 10.65 212 240301 39047 29294967
C-reactive protein abnormal 20.48 10.65 14 240499 6522 29327492
Rhinalgia 20.44 10.65 20 240493 360 29333654
Eosinophilia 20.18 10.65 102 240411 22059 29311955
Chest discomfort 20.11 10.65 503 240010 45480 29288534
Osteonecrosis of jaw 20.01 10.65 68 240445 16442 29317572
Hospitalisation 19.86 10.65 259 240254 45729 29288285
Lymphocyte count abnormal 19.85 10.65 25 240488 602 29333412
Hypertriglyceridaemia 19.70 10.65 19 240494 7456 29326558
Eyelid rash 19.67 10.65 8 240505 24 29333990
Hepatocellular carcinoma 19.60 10.65 17 240496 7021 29326993
Acute myocardial infarction 19.41 10.65 277 240236 48161 29285853
Anaesthetic complication neurological 19.18 10.65 18 240495 307 29333707
Infusion site erythema 19.10 10.65 42 240471 1622 29332392
Lymphocyte percentage decreased 18.88 10.65 47 240466 1970 29332044
Apparent death 18.74 10.65 3 240510 3501 29330513
Myopathy 18.46 10.65 36 240477 10497 29323517
Myocardial fibrosis 18.42 10.65 32 240481 1036 29332978
Mental status changes 18.35 10.65 392 240121 34535 29299479
Hypocalcaemia 18.31 10.65 96 240417 20569 29313445
Hyperhidrosis 18.24 10.65 669 239844 63871 29270143
Pemphigoid 18.04 10.65 21 240492 7560 29326454
Blood pressure decreased 18.01 10.65 491 240022 44986 29289028
Altered state of consciousness 17.85 10.65 92 240421 19797 29314217
Agranulocytosis 17.74 10.65 95 240418 20245 29313769
Polyneuropathy 17.65 10.65 46 240467 12106 29321908
Thrombotic microangiopathy 17.65 10.65 27 240486 8654 29325360
Bladder cancer 17.41 10.65 35 240478 10092 29323922
Urine sodium decreased 17.25 10.65 13 240500 161 29333853
Body temperature fluctuation 17.10 10.65 37 240476 1413 29332601
Inappropriate antidiuretic hormone secretion 16.96 10.65 40 240473 10892 29323122
Brain death 16.94 10.65 50 240463 2320 29331694
Akathisia 16.78 10.65 18 240495 6724 29327290
Sleep disorder due to general medical condition, insomnia type 16.69 10.65 34 240479 1244 29332770
Chronic graft versus host disease 16.58 10.65 6 240507 4023 29329991
Haemolysis 16.52 10.65 105 240408 6851 29327163
Arthralgia 16.51 10.65 1334 239179 138283 29195731
Diabetic ketoacidosis 16.39 10.65 71 240442 16002 29318012
Vitreous disorder 16.38 10.65 10 240503 85 29333929
Oculocardiac reflex 16.30 10.65 9 240504 62 29333952
Floppy iris syndrome 16.22 10.65 16 240497 291 29333723
Inadequate analgesia 16.20 10.65 53 240460 2601 29331413
Haematuria 16.11 10.65 257 240256 43882 29290132
Anxiety 15.95 10.65 848 239665 84517 29249497
Prostate cancer 15.84 10.65 132 240381 25395 29308619
Exposure via ingestion 15.81 10.65 44 240469 1974 29332040
Infusion site rash 15.68 10.65 17 240496 347 29333667
Unevaluable event 15.67 10.65 335 240178 29516 29304498
Psychotic disorder 15.65 10.65 99 240414 20255 29313759
Inappropriate schedule of product administration 15.63 10.65 473 240040 43999 29290015
Granulomatosis with polyangiitis 15.43 10.65 27 240486 879 29333135
Aspartate aminotransferase increased 15.42 10.65 613 239900 59112 29274902
Feeling hot 15.33 10.65 193 240320 15295 29318719
Chronic gastrointestinal bleeding 15.33 10.65 15 240498 270 29333744
Poisoning 15.30 10.65 136 240377 9857 29324157
Croup infectious 15.29 10.65 15 240498 271 29333743
Pemphigus 15.17 10.65 31 240482 1137 29332877
Kidney transplant rejection 15.01 10.65 21 240492 6984 29327030
Pathogen resistance 14.87 10.65 27 240486 8089 29325925
Pneumocystis jirovecii pneumonia 14.84 10.65 78 240435 16701 29317313
Febrile bone marrow aplasia 14.82 10.65 23 240490 7328 29326686
COVID-19 immunisation 14.81 10.65 11 240502 133 29333881
Infusion site bruising 14.75 10.65 17 240496 372 29333642
Oedema peripheral 14.71 10.65 690 239823 102867 29231147
Intracranial hypotension 14.62 10.65 13 240500 206 29333808
Pulmonary fibrosis 14.60 10.65 71 240442 15511 29318503
Dermatitis exfoliative generalised 14.51 10.65 3 240510 2913 29331101
Electrocardiogram QRS complex prolonged 14.44 10.65 69 240444 4041 29329973
Apnoea 14.42 10.65 92 240421 6010 29328004
Pleural thickening 14.23 10.65 15 240498 296 29333718
Administration site pain 14.20 10.65 12 240501 177 29333837
Rhinorrhoea 14.18 10.65 250 240263 21269 29312745
Ductus arteriosus premature closure 14.12 10.65 13 240500 216 29333798
Pharyngeal paraesthesia 14.02 10.65 18 240495 442 29333572
Acute graft versus host disease 14.00 10.65 16 240497 5808 29328206
Shock haemorrhagic 13.99 10.65 36 240477 9515 29324499
Mydriasis 13.92 10.65 91 240422 5994 29328020
Alanine aminotransferase increased 13.91 10.65 708 239805 70236 29263778
Myocardial ischaemia 13.90 10.65 75 240438 15953 29318061
Cough 13.90 10.65 1204 239309 125523 29208491
Cerebral artery thrombosis 13.81 10.65 23 240490 719 29333295
Specific gravity urine decreased 13.78 10.65 9 240504 87 29333927
Gynaecomastia 13.62 10.65 29 240484 8188 29325826
Liver disorder 13.61 10.65 152 240361 27597 29306417
Upper respiratory tract infection 13.42 10.65 304 240209 27045 29306969
Prothrombin time prolonged 13.42 10.65 120 240393 8712 29325302
Palmar-plantar erythrodysaesthesia syndrome 13.39 10.65 68 240445 14691 29319323
Tooth infection 13.39 10.65 84 240429 5455 29328559
Serum sickness 13.35 10.65 38 240475 1727 29332287
C-reactive protein decreased 13.34 10.65 35 240478 1516 29332498
Tuberculosis 13.13 10.65 24 240489 7172 29326842
Pulmonary oedema 13.06 10.65 447 240066 42288 29291726
Red cell distribution width increased 13.06 10.65 74 240439 4633 29329381
Therapeutic product effect decreased 13.03 10.65 165 240348 29286 29304728
Delayed recovery from anaesthesia 12.91 10.65 22 240491 701 29333313
Dyspnoea at rest 12.87 10.65 5 240508 3209 29330805
Syncope 12.82 10.65 536 239977 80835 29253179
Monocyte percentage increased 12.78 10.65 25 240488 888 29333126
Toxic epidermal necrolysis 12.72 10.65 213 240300 17940 29316074
Treatment noncompliance 12.57 10.65 131 240382 24096 29309918
Second primary malignancy 12.56 10.65 22 240491 6683 29327331
Anion gap abnormal 12.44 10.65 10 240503 137 29333877
Fungal rhinitis 12.41 10.65 6 240507 30 29333984
Cardiac failure chronic 12.32 10.65 21 240492 6446 29327568
Gastrointestinal haemorrhage 12.30 10.65 525 239988 79008 29255006
Disease progression 12.19 10.65 543 239970 81373 29252641
Virologic failure 12.13 10.65 4 240509 2843 29331171
Oropharyngeal pain 12.11 10.65 318 240195 28967 29305047
Low birth weight baby 12.09 10.65 22 240491 6586 29327428
Stevens-Johnson syndrome 12.09 10.65 195 240318 16302 29317712
Proteinuria 12.08 10.65 77 240436 15727 29318287
Photosensitivity reaction 12.01 10.65 37 240476 9221 29324793
Cystitis haemorrhagic 11.97 10.65 13 240500 4829 29329185
Leukoencephalopathy 11.89 10.65 8 240505 3759 29330255
Crystal urine present 11.86 10.65 16 240497 413 29333601
Urethral valves 11.81 10.65 13 240500 270 29333744
Aspiration joint 11.78 10.65 8 240505 83 29333931
Post concussion syndrome 11.77 10.65 9 240504 114 29333900
Laryngeal stenosis 11.71 10.65 8 240505 84 29333930
Bronchopulmonary aspergillosis 11.71 10.65 56 240457 12288 29321726
Pallor 11.70 10.65 238 240275 20786 29313228
Mania 11.68 10.65 34 240479 8629 29325385
Renal papillary necrosis 11.64 10.65 10 240503 151 29333863
Cytomegalovirus viraemia 11.60 10.65 21 240492 6299 29327715
Infusion site discomfort 11.58 10.65 9 240504 117 29333897
Brain scan abnormal 11.56 10.65 23 240490 827 29333187
Viral mutation identified 11.51 10.65 3 240510 2485 29331529
Vitreous degeneration 11.46 10.65 3 240510 0 29334014
Hypertension 11.43 10.65 1099 239414 115515 29218499
Urine abnormality 11.41 10.65 35 240478 1659 29332355
Pupillary light reflex tests abnormal 11.39 10.65 9 240504 120 29333894
Acute lung injury 11.38 10.65 30 240483 1303 29332711
Congestive cardiomyopathy 11.33 10.65 23 240490 6607 29327407
Bone pain 11.33 10.65 212 240301 18240 29315774
Dependent personality disorder 11.32 10.65 8 240505 89 29333925
Epstein-Barr virus infection 11.32 10.65 23 240490 6606 29327408
Aspergillus infection 11.24 10.65 46 240467 10535 29323479
BK virus infection 11.24 10.65 13 240500 4694 29329320
Reperfusion arrhythmia 11.23 10.65 7 240506 62 29333952
Administration site pruritus 11.22 10.65 5 240508 20 29333994
Appendicolith 11.21 10.65 57 240456 3423 29330591
Lagophthalmos 11.10 10.65 8 240505 92 29333922
Intentional self-injury 10.98 10.65 58 240455 12403 29321611
Oral pruritus 10.95 10.65 12 240501 248 29333766
Erysipelas 10.83 10.65 11 240502 4214 29329800
Injection site pain 10.83 10.65 192 240321 32254 29301760
Illness 10.83 10.65 92 240421 6582 29327432
Pyrexia 10.78 10.65 2566 237947 285056 29048958
Therapy partial responder 10.73 10.65 16 240497 5183 29328831
Hepatic cirrhosis 10.72 10.65 71 240442 14373 29319641
Anaphylactic shock 10.68 10.65 160 240353 13176 29320838

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1967.29 10.31 5705 621908 218709 63652410
Toxicity to various agents 1402.11 10.31 7111 620502 356402 63514717
Infusion related reaction 1007.39 10.31 3703 623910 160764 63710355
Blood pressure fluctuation 602.60 10.31 1466 626147 50405 63820714
Exposure to toxic agent 597.57 10.31 489 627124 5670 63865449
Acute hepatic failure 554.68 10.31 948 626665 25164 63845955
Drug interaction 448.36 10.31 1906 625707 360177 63510942
Intentional product misuse 442.17 10.31 1628 625985 70667 63800452
Overdose 364.38 10.31 2730 624883 156836 63714283
Blood pressure increased 310.93 10.31 2798 624815 169754 63701365
Heart rate decreased 276.73 10.31 1166 626447 53901 63817218
Sinusitis 256.06 10.31 2353 625260 143575 63727544
Rheumatoid arthritis 250.91 10.31 2573 625040 161721 63709398
Anaemia 227.18 10.31 2472 625141 376208 63494911
Sopor 220.73 10.31 18 627595 29643 63841476
Intentional overdose 215.49 10.31 1557 626056 88387 63782732
Drug resistance 211.61 10.31 42 627571 35060 63836059
Cardiac failure 207.85 10.31 630 626983 131743 63739376
Anion gap 206.27 10.31 160 627453 1707 63869412
Blood pressure diastolic abnormal 200.27 10.31 391 627222 11526 63859593
Acute kidney injury 200.09 10.31 3121 624492 446119 63425000
Metabolic acidosis 199.59 10.31 1278 626335 69680 63801439
Oxygen saturation decreased 194.48 10.31 1741 625872 105435 63765684
Heart rate increased 192.11 10.31 1628 625985 97047 63774072
Neutropenia 168.79 10.31 1504 626109 238120 63632999
Bone marrow failure 166.76 10.31 133 627480 47819 63823300
Blood pressure systolic increased 164.79 10.31 931 626682 48522 63822597
Interstitial lung disease 163.73 10.31 451 627162 97281 63773838
Nasopharyngitis 163.12 10.31 2748 624865 193325 63677794
Local anaesthetic systemic toxicity 153.54 10.31 91 627522 594 63870525
Blood pressure systolic abnormal 150.12 10.31 312 627301 9630 63861489
Irritable bowel syndrome 149.53 10.31 740 626873 36629 63834490
Muscle injury 148.86 10.31 580 627033 25857 63845262
Pancytopenia 147.47 10.31 805 626808 142504 63728615
Hepatotoxicity 140.94 10.31 764 626849 39198 63831921
General physical health deterioration 138.31 10.31 1296 626317 203129 63667990
Coagulopathy 137.02 10.31 645 626968 31275 63839844
Injection site pain 134.73 10.31 591 627022 110817 63760302
Body temperature increased 133.40 10.31 707 626906 35959 63835160
Toxic anterior segment syndrome 132.21 10.31 140 627473 2299 63868820
Folliculitis 131.48 10.31 611 627002 29466 63841653
Throat irritation 129.63 10.31 646 626967 32065 63839054
Hyperkalaemia 127.49 10.31 528 627085 100601 63770518
Osteonecrosis of jaw 126.91 10.31 120 627493 39705 63831414
Intentional product use issue 120.92 10.31 1440 626173 93924 63777195
Sleep disorder due to general medical condition, insomnia type 120.28 10.31 541 627072 25729 63845390
Leukopenia 119.45 10.31 542 627071 100700 63770419
Respiratory arrest 118.21 10.31 902 626711 52083 63819036
Septic shock 113.05 10.31 584 627029 104853 63766266
Pain 112.82 10.31 6520 621093 546991 63324128
Myocardial infarction 110.96 10.31 1054 626559 164767 63706352
Flushing 108.40 10.31 1207 626406 77441 63793678
Thrombocytopenia 107.95 10.31 1530 626083 222271 63648848
Blood pressure diastolic decreased 105.68 10.31 464 627149 21837 63849282
Mucosal inflammation 105.40 10.31 288 627325 62296 63808823
Diarrhoea 104.58 10.31 5861 621752 716843 63154276
Analgesic drug level increased 103.50 10.31 119 627494 2151 63868968
Drug ineffective 103.46 10.31 6918 620695 833329 63037790
Medication error 103.42 10.31 836 626777 49130 63821989
Hepatic necrosis 103.21 10.31 244 627369 8229 63862890
Duodenal ulcer perforation 103.17 10.31 633 626980 33992 63837127
Cytomegalovirus infection 100.95 10.31 128 627485 37071 63834048
Ill-defined disorder 97.75 10.31 749 626864 43303 63827816
Blood pressure diastolic increased 97.35 10.31 277 627336 10475 63860644
Weight increased 97.02 10.31 2741 624872 210607 63660512
Device expulsion 96.97 10.31 42 627571 21094 63850025
Hepatic enzyme increased 96.50 10.31 1789 625824 128154 63742965
Helicobacter infection 96.44 10.31 672 626941 37690 63833429
Malignant neoplasm progression 96.32 10.31 672 626941 112199 63758920
Myelosuppression 94.92 10.31 57 627556 23773 63847346
Urticaria 94.21 10.31 1983 625630 145334 63725785
Chills 94.16 10.31 1867 625746 135397 63735722
Renal impairment 93.41 10.31 851 626762 134166 63736953
Hyponatraemia 93.32 10.31 957 626656 147382 63723737
Lower respiratory tract infection 92.60 10.31 1363 626250 93251 63777868
Product prescribing error 91.98 10.31 125 627488 35144 63835975
Injection site erythema 91.52 10.31 366 627247 70434 63800685
Respiratory depression 90.79 10.31 460 627153 22983 63848136
Lactic acidosis 90.22 10.31 301 627312 61109 63810010
Cardiac failure congestive 89.05 10.31 826 626787 129754 63741365
Rhabdomyolysis 88.52 10.31 526 627087 91200 63779919
Ear pain 87.58 10.31 479 627134 24657 63846462
Urine abnormality 87.51 10.31 210 627403 7152 63863967
Wrong technique in product usage process 85.82 10.31 333 627280 64641 63806478
Accidental overdose 81.53 10.31 583 627030 32974 63838145
Hepatic cytolysis 81.36 10.31 311 627302 13738 63857381
Haematotoxicity 80.79 10.31 14 627599 12882 63858237
Product use in unapproved indication 80.76 10.31 1220 626393 175398 63695721
Heart rate irregular 79.69 10.31 498 627115 26915 63844204
Hepatocellular injury 78.56 10.31 205 627408 45030 63826089
Anti-cyclic citrullinated peptide antibody positive 78.32 10.31 782 626831 48780 63822339
Agranulocytosis 77.88 10.31 159 627454 38070 63833049
Product dose omission issue 77.25 10.31 1381 626232 193366 63677753
Back pain 76.91 10.31 3070 624543 247101 63624018
Blister 73.65 10.31 1152 626461 79815 63791304
Urine leukocyte esterase positive 72.84 10.31 124 627489 3279 63867840
Electrocardiogram QT prolonged 71.78 10.31 465 627148 78983 63792136
Psoriasis 69.27 10.31 411 627202 71292 63799827
Blood calcium decreased 69.22 10.31 456 627157 25098 63846021
Methaemoglobinaemia 68.65 10.31 139 627474 4209 63866910
Cerebral infarction 68.27 10.31 190 627423 40854 63830265
White blood cells urine positive 67.44 10.31 157 627456 5241 63865878
Injection site reaction 66.99 10.31 231 627382 46433 63824686
Anaphylactic reaction 65.93 10.31 986 626627 67678 63803441
Epilepsy 65.34 10.31 143 627470 33388 63837731
Peripheral swelling 65.28 10.31 2571 625042 206582 63664537
Cerebral haemorrhage 64.83 10.31 266 627347 50824 63820295
Urinary sediment present 63.92 10.31 93 627520 2141 63868978
Hypotension 63.70 10.31 4413 623200 376561 63494558
Anaesthetic complication 63.35 10.31 100 627513 2479 63868640
Depressed level of consciousness 63.17 10.31 1129 626484 80307 63790812
Joint swelling 62.94 10.31 2629 624984 212753 63658366
Red cell distribution width increased 62.87 10.31 262 627351 12047 63859072
Pyroglutamic acidosis 62.26 10.31 54 627559 682 63870437
Acute lung injury 61.77 10.31 102 627511 2629 63868490
Arthralgia 60.47 10.31 5042 622571 437218 63433901
Hypocalcaemia 60.41 10.31 206 627407 41547 63829572
Muscle spasticity 60.34 10.31 321 627292 16348 63854771
Liver injury 59.88 10.31 497 627116 29435 63841684
Discomfort 59.84 10.31 1113 626500 79765 63791354
Sedation complication 59.79 10.31 229 627384 10125 63860994
Body temperature decreased 59.28 10.31 444 627169 25484 63845635
Cardio-respiratory arrest 59.20 10.31 1313 626300 97080 63774039
Diabetes mellitus 58.56 10.31 392 627221 66082 63805037
Disease progression 58.30 10.31 998 626615 140682 63730437
Pneumocystis jirovecii pneumonia 57.95 10.31 113 627500 27521 63843598
Infusion site extravasation 56.97 10.31 171 627442 6666 63864453
Post transplant lymphoproliferative disorder 56.32 10.31 12 627601 9532 63861587
Crystal urine present 56.21 10.31 81 627532 1848 63869271
Blood parathyroid hormone decreased 56.14 10.31 4 627609 7362 63863757
Impaired healing 55.98 10.31 863 626750 59610 63811509
Lymphocyte count decreased 55.78 10.31 624 626989 40075 63831044
Chest discomfort 55.34 10.31 1501 626112 114605 63756514
Respiratory rate increased 55.16 10.31 336 627277 17995 63853124
Graft versus host disease 55.07 10.31 33 627580 13780 63857339
Headache 54.50 10.31 5916 621697 523551 63347568
Injection site pruritus 54.47 10.31 187 627426 37639 63833480
Body temperature fluctuation 53.95 10.31 107 627506 3191 63867928
Pruritus 53.65 10.31 3627 623986 308773 63562346
Injury 52.96 10.31 802 626811 55190 63815929
Hand deformity 52.93 10.31 882 626731 61889 63809230
Lymphocyte percentage decreased 52.47 10.31 130 627483 4519 63866600
Decreased appetite 52.47 10.31 2220 625393 279069 63592050
Labelled drug-drug interaction medication error 51.87 10.31 84 627529 21978 63849141
Haematuria 51.58 10.31 360 627253 60111 63811008
Pericarditis 51.46 10.31 875 626738 61641 63809478
Suspected suicide 51.29 10.31 193 627420 8461 63862658
Diabetic ketoacidosis 51.25 10.31 136 627477 29709 63841410
Temperature regulation disorder 51.00 10.31 121 627492 4090 63867029
Myelodysplastic syndrome 51.00 10.31 121 627492 27458 63843661
Injection site swelling 50.80 10.31 218 627395 41135 63829984
Therapeutic response shortened 50.79 10.31 215 627398 9955 63861164
Wound 50.67 10.31 1035 626578 75442 63795677
Posterior reversible encephalopathy syndrome 50.62 10.31 91 627522 22855 63848264
Injection site bruising 50.25 10.31 183 627430 36190 63834929
Urine analysis abnormal 49.90 10.31 146 627467 5610 63865509
Substance abuse 49.20 10.31 200 627413 9092 63862027
Neutrophil percentage increased 48.81 10.31 123 627490 4322 63866797
Inappropriate antidiuretic hormone secretion 47.74 10.31 90 627523 22199 63848920
Exposure via ingestion 47.05 10.31 129 627484 4773 63866346
Poor venous access 46.93 10.31 242 627371 12175 63858944
Acute graft versus host disease 46.79 10.31 15 627598 9069 63862050
Immune reconstitution inflammatory syndrome 46.70 10.31 32 627581 12438 63858681
Contusion 46.53 10.31 1445 626168 112520 63758599
Red blood cell sedimentation rate abnormal 46.47 10.31 54 627559 16252 63854867
Infusion site pain 46.02 10.31 212 627401 10185 63860934
Pathogen resistance 45.90 10.31 33 627580 12510 63858609
Therapeutic product effect incomplete 45.84 10.31 719 626894 102763 63768356
Poisoning 45.77 10.31 367 627246 21512 63849607
Drug reaction with eosinophilia and systemic symptoms 45.64 10.31 324 627289 53893 63817226
Thrombotic microangiopathy 45.51 10.31 57 627556 16598 63854521
Blood pH decreased 45.43 10.31 119 627494 4283 63866836
Hypomagnesaemia 45.32 10.31 198 627415 37178 63833941
Creatinine renal clearance decreased 45.10 10.31 267 627346 14154 63856965
Bursitis 44.73 10.31 360 627253 21125 63849994
Altered state of consciousness 44.63 10.31 203 627410 37699 63833420
Melaena 44.59 10.31 321 627292 53227 63817892
Oedema peripheral 44.38 10.31 1636 625977 208681 63662438
Ear pruritus 44.36 10.31 87 627526 2573 63868546
Blood urine present 43.60 10.31 317 627296 18023 63853096
Oropharyngeal pain 43.52 10.31 1153 626460 87714 63783405
Febrile bone marrow aplasia 43.34 10.31 28 627585 11227 63859892
Red blood cells urine positive 43.13 10.31 118 627495 4360 63866759
Hepatic function abnormal 42.89 10.31 409 627204 63904 63807215
Palmar-plantar erythrodysaesthesia syndrome 42.50 10.31 141 627472 28678 63842441
Anion gap abnormal 42.44 10.31 38 627575 502 63870617
Gastrointestinal disorder 41.96 10.31 1157 626456 88552 63782567
Granuloma skin 41.76 10.31 5 627608 6069 63865050
Hypokalaemia 41.74 10.31 886 626727 121017 63750102
Drug eruption 41.68 10.31 195 627418 35941 63835178
Pemphigus 41.37 10.31 825 626788 59876 63811243
Acute myocardial infarction 41.30 10.31 456 627157 69262 63801857
Polyneuropathy 41.16 10.31 82 627531 19812 63851307
Transplant rejection 41.15 10.31 66 627547 17335 63853784
Neuropathy peripheral 40.88 10.31 852 626761 116673 63754446
Fatigue 40.66 10.31 8064 619549 740666 63130453
Infusion site erythema 40.50 10.31 153 627460 6720 63864399
Swelling 40.47 10.31 1927 625686 158291 63712828
Pancreatitis acute 40.15 10.31 248 627365 42607 63828512
Glossodynia 39.75 10.31 866 626747 63830 63807289
Eosinophilia 39.61 10.31 213 627400 37863 63833256
Culture urine positive 39.60 10.31 109 627504 4042 63867077
Second primary malignancy 39.51 10.31 37 627576 12300 63858819
Cardiac arrest 39.13 10.31 1854 625759 152210 63718909
Prothrombin time prolonged 39.12 10.31 275 627338 15466 63855653
Night sweats 38.74 10.31 528 627085 35518 63835601
Multiple-drug resistance 38.73 10.31 8 627605 6494 63864625
Infusion site swelling 38.50 10.31 129 627484 5336 63865783
Stress 38.38 10.31 814 626799 59720 63811399
Pyroglutamate increased 38.37 10.31 39 627574 609 63870510
Bronchopulmonary aspergillosis 38.35 10.31 80 627533 19005 63852114
Unresponsive to stimuli 37.79 10.31 695 626918 49698 63821421
Food allergy 37.69 10.31 164 627449 7687 63863432
Hypersensitivity 37.52 10.31 2302 625311 194150 63676969
Aspergillus infection 36.99 10.31 64 627549 16315 63854804
Unintentional medical device removal 36.73 10.31 10 627603 6724 63864395
Transplant dysfunction 36.52 10.31 10 627603 6698 63864421
Device use error 36.46 10.31 9 627604 6462 63864657
Osteonecrosis 36.42 10.31 146 627467 28083 63843036
Infusion site pruritus 36.13 10.31 79 627534 2527 63868592
Drug hypersensitivity 35.77 10.31 1920 625693 235895 63635224
Anhedonia 35.57 10.31 242 627371 13464 63857655
Coronary artery disease 35.50 10.31 396 627217 60037 63811082
Electric shock 35.25 10.31 49 627564 1080 63870039
Hepatocellular carcinoma 35.04 10.31 19 627594 8384 63862735
Brain death 34.47 10.31 115 627498 4746 63866373
Feeling hot 34.32 10.31 630 626983 45033 63826086
Panniculitis 34.31 10.31 22 627591 8857 63862262
Acute myeloid leukaemia 34.21 10.31 144 627469 27319 63843800
Gastrointestinal haemorrhage 34.10 10.31 1003 626610 131309 63739810
Pleural thickening 34.05 10.31 79 627534 2631 63868488
Akathisia 34.02 10.31 37 627576 11473 63859646
Syncope 33.96 10.31 1223 626390 156412 63714707
Specific gravity urine decreased 33.95 10.31 40 627573 743 63870376
Epstein-Barr virus infection 33.85 10.31 43 627570 12445 63858674
Condition aggravated 33.76 10.31 3142 624471 369284 63501835
Venoocclusive liver disease 33.31 10.31 29 627584 9986 63861133
Hospitalisation 33.15 10.31 523 627090 74684 63796435
Eyelid rash 33.09 10.31 17 627596 80 63871039
Toxic skin eruption 33.02 10.31 88 627525 19196 63851923
Cytomegalovirus viraemia 32.91 10.31 34 627579 10794 63860325
Emotional distress 32.85 10.31 513 627100 35525 63835594
Intentional self-injury 32.75 10.31 158 627455 28886 63842233
Bacterial test 32.74 10.31 49 627564 1158 63869961
Renal failure 32.37 10.31 1441 626172 180247 63690872
Hepatic failure 31.99 10.31 735 626878 54659 63816460
Product monitoring error 31.89 10.31 7 627606 5447 63865672
Abortion spontaneous 31.84 10.31 131 627482 25012 63846107
Shock haemorrhagic 31.58 10.31 73 627540 16718 63854401
Hypoglycaemia 31.46 10.31 651 626962 89241 63781878
Renal injury 31.29 10.31 257 627356 15172 63855947
Death 31.25 10.31 5247 622366 477458 63393661
Chronic graft versus host disease 31.22 10.31 11 627602 6265 63864854
Neuroleptic malignant syndrome 31.17 10.31 131 627482 24865 63846254
Off label use 31.10 10.31 5552 622061 627254 63243865
Hypercalcaemia 30.38 10.31 180 627433 31236 63839883
Angina pectoris 30.35 10.31 286 627327 44795 63826324
Blood magnesium increased 29.99 10.31 84 627529 3147 63867972
Angioedema 29.98 10.31 422 627191 61399 63809720
Disorientation 29.65 10.31 374 627239 55454 63815665
Cholestasis 29.64 10.31 286 627327 44586 63826533
Pulmonary fibrosis 29.52 10.31 170 627443 29708 63841411
Cerebrovascular accident 29.50 10.31 1068 626545 136515 63734604
Anxiety 29.49 10.31 2322 625291 200327 63670792
Fear 29.36 10.31 313 627300 19858 63851261
Bacterial test positive 29.30 10.31 136 627477 6554 63864565
Rash maculo-papular 29.29 10.31 304 627309 46722 63824397
Myopathy 29.28 10.31 82 627531 17598 63853521
Metastases to liver 28.92 10.31 127 627486 23814 63847305
Pleural fibrosis 28.89 10.31 96 627517 3954 63867165
Specific gravity urine increased 28.54 10.31 28 627585 418 63870701
Therapeutic product effect decreased 28.20 10.31 1383 626230 113968 63757151
Erysipelas 28.19 10.31 28 627585 9053 63862066
Monocyte percentage increased 28.15 10.31 61 627552 1939 63869180
Rheumatoid nodule 28.06 10.31 50 627563 12601 63858518
Congestive cardiomyopathy 27.64 10.31 36 627577 10308 63860811
Multiple organ dysfunction syndrome 27.59 10.31 763 626850 100650 63770469
Platelet count decreased 27.50 10.31 1342 626271 166369 63704750
Fracture 27.49 10.31 92 627521 18663 63852456
Skin toxicity 27.43 10.31 15 627598 6587 63864532
Analgesic drug level above therapeutic 27.32 10.31 27 627586 407 63870712
Extrapyramidal disorder 27.25 10.31 98 627515 19454 63851665
Hepatitis B reactivation 27.16 10.31 7 627606 4882 63866237
Neoplasm progression 27.10 10.31 261 627352 40703 63830416
Ascites 27.04 10.31 432 627181 61569 63809550
Glycosylated haemoglobin increased 26.75 10.31 74 627539 15945 63855174
Liver disorder 26.65 10.31 362 627251 52989 63818130
Pulmonary tuberculosis 26.58 10.31 19 627594 7225 63863894
Injection site warmth 26.57 10.31 57 627556 13405 63857714
Kidney transplant rejection 26.57 10.31 32 627581 9479 63861640
Hallucination, auditory 26.29 10.31 81 627532 16858 63854261
Graft versus host disease in gastrointestinal tract 25.99 10.31 11 627602 5601 63865518
Urine ketone body present 25.96 10.31 81 627532 3226 63867893
Leukoencephalopathy 25.93 10.31 18 627595 6949 63864170
Metastases to lung 25.87 10.31 70 627543 15194 63855925
Parkinsonism 25.83 10.31 64 627549 14309 63856810
Hypersensitivity vasculitis 25.79 10.31 17 627596 6744 63864375
Prostate cancer 25.78 10.31 102 627511 19693 63851426
Red blood cell sedimentation rate 25.67 10.31 3 627610 3711 63867408
C-reactive protein increased 25.58 10.31 715 626898 94194 63776925
Graft versus host disease in skin 25.54 10.31 10 627603 5337 63865782
Arthropathy 25.46 10.31 1430 626183 119537 63751582
Cystitis haemorrhagic 25.31 10.31 24 627589 7932 63863187
Human herpesvirus 6 infection 25.22 10.31 7 627606 4647 63866472
Throat tightness 25.19 10.31 340 627273 22820 63848299
Injection site haemorrhage 25.15 10.31 136 627477 24142 63846977
Acute graft versus host disease in skin 25.13 10.31 18 627595 6837 63864282
Hypertensive crisis 25.08 10.31 92 627521 18156 63852963
Cognitive disorder 25.06 10.31 708 626905 54379 63816740
Therapy cessation 25.04 10.31 199 627414 32290 63838829
Presbyacusis 24.95 10.31 68 627545 2507 63868612
Hypertransaminasaemia 24.93 10.31 20 627593 7171 63863948
Systemic lupus erythematosus 24.87 10.31 957 626656 76655 63794464
Skin necrosis 24.83 10.31 65 627548 14264 63856855
Lymphopenia 24.81 10.31 147 627466 25510 63845609
Hepatic cirrhosis 24.73 10.31 152 627461 26146 63844973
Gamma-glutamyltransferase increased 24.65 10.31 328 627285 48182 63822937
Mania 24.48 10.31 79 627534 16207 63854912
Accidental exposure to product by child 24.45 10.31 66 627547 2419 63868700
Nocardiosis 24.33 10.31 8 627605 4759 63866360
Anion gap increased 24.30 10.31 75 627538 2969 63868150
Haemophagocytic lymphohistiocytosis 24.05 10.31 89 627524 17520 63853599
Dyspnoea at rest 24.02 10.31 16 627597 6313 63864806
Maternal exposure during delivery 23.95 10.31 36 627577 854 63870265
Anaesthetic complication neurological 23.89 10.31 28 627585 517 63870602
Lipodystrophy acquired 23.89 10.31 5 627608 4022 63867097
Coeliac disease 23.67 10.31 138 627475 7274 63863845
Proteinuria 23.66 10.31 165 627448 27558 63843561
Cytokine release syndrome 23.58 10.31 308 627305 20521 63850598
Haemolysis 23.54 10.31 186 627427 10853 63860266
Malaise 23.52 10.31 3439 624174 392808 63478311
Device malfunction 23.51 10.31 90 627523 17543 63853576
Pneumonia 23.51 10.31 4949 622664 554627 63316492
Virologic failure 23.47 10.31 3 627610 3463 63867656
Product storage error 23.39 10.31 60 627553 13258 63857861
Disease recurrence 23.37 10.31 195 627418 31315 63839804
Haemoglobin urine present 23.36 10.31 35 627578 828 63870291
Product substitution issue 23.28 10.31 92 627521 17769 63853350
Immunosuppressant drug level increased 22.97 10.31 22 627591 7237 63863882
BK virus infection 22.84 10.31 23 627590 7389 63863730
Treatment noncompliance 22.83 10.31 292 627321 43190 63827929
Gestational diabetes 22.79 10.31 13 627600 5577 63865542
Disturbance in social behaviour 22.71 10.31 5 627608 3882 63867237
Synovitis 22.56 10.31 1180 626433 97910 63773209
Oesophageal carcinoma 22.44 10.31 9 627604 4734 63866385
Hyperglycaemia 22.38 10.31 438 627175 60530 63810589
Haematemesis 22.37 10.31 322 627291 46677 63824442
Basal cell carcinoma 22.35 10.31 192 627421 30646 63840473
Lagophthalmos 22.24 10.31 22 627591 332 63870787
Antipsychotic drug level increased 22.17 10.31 11 627602 5104 63866015
Hypoglycaemic coma 22.12 10.31 7 627606 4267 63866852
Lymphoproliferative disorder 22.08 10.31 11 627602 5092 63866027
Dysarthria 22.05 10.31 426 627187 58980 63812139
Subdural haematoma 22.01 10.31 171 627442 27883 63843236
Disturbance in attention 21.87 10.31 275 627338 40799 63830320
Ischaemic stroke 21.84 10.31 179 627434 28856 63842263
Peritonitis 21.81 10.31 148 627465 24875 63846244
Device issue 21.77 10.31 130 627483 22518 63848601
Mean cell haemoglobin concentration decreased 21.70 10.31 82 627531 3602 63867517
Cardiac failure chronic 21.65 10.31 34 627579 9007 63862112
Dehydration 21.47 10.31 1816 625797 214947 63656172
Enthesopathy 21.46 10.31 38 627575 9600 63861519
C-reactive protein abnormal 21.43 10.31 180 627433 28867 63842252
Cardiac failure acute 21.42 10.31 84 627529 16260 63854859
Galactorrhoea 21.29 10.31 3 627610 3216 63867903
Cytopenia 21.26 10.31 78 627535 15393 63855726
Drug screen positive 21.20 10.31 111 627502 5618 63865501
Diffuse large B-cell lymphoma 21.18 10.31 43 627570 10318 63860801
Therapy non-responder 21.10 10.31 484 627129 65415 63805704
Migraine 21.07 10.31 777 626836 61900 63809219
Corneal oedema 20.86 10.31 60 627553 2283 63868836
Hypertriglyceridaemia 20.84 10.31 49 627564 11156 63859963
Atrial fibrillation 20.80 10.31 1409 626204 169680 63701439
Coronary arterial stent insertion 20.79 10.31 15 627598 5677 63865442
Brain oedema 20.79 10.31 316 627297 21759 63849360
Oxygen saturation abnormal 20.63 10.31 79 627534 3492 63867627
Tardive dyskinesia 20.60 10.31 36 627577 9142 63861977
Bone erosion 20.55 10.31 52 627561 11543 63859576
Aggression 20.54 10.31 321 627292 45911 63825208
Blood creatinine decreased 20.44 10.31 128 627485 6922 63864197
Skin ulcer 20.33 10.31 303 627310 43671 63827448
Surgery 20.29 10.31 176 627437 28037 63843082
Pulmonary alveolar haemorrhage 20.26 10.31 40 627573 9698 63861421
Sexual dysfunction 20.03 10.31 20 627593 6451 63864668
Loss of personal independence in daily activities 20.00 10.31 544 627069 71910 63799209
Fibromyalgia 19.98 10.31 472 627141 35259 63835860
Renal papillary necrosis 19.92 10.31 21 627592 343 63870776
Incorrect drug administration rate 19.88 10.31 65 627548 2654 63868465
Bilirubin urine present 19.79 10.31 20 627593 310 63870809
Hepatitis B 19.64 10.31 28 627585 7717 63863402
Serum sickness 19.63 10.31 72 627541 3117 63868002
Blood creatine phosphokinase increased 19.63 10.31 427 627186 58131 63812988
Gynaecomastia 19.31 10.31 18 627595 5998 63865121
Suicidal ideation 19.31 10.31 496 627117 66046 63805073
PO2 increased 19.31 10.31 44 627569 1448 63869671
Systemic infection 19.17 10.31 9 627604 4312 63866807
Mucormycosis 19.16 10.31 26 627587 7315 63863804
Tachycardia 19.06 10.31 1697 625916 147882 63723237
Varicella zoster virus infection 19.02 10.31 7 627606 3881 63867238
Metastases to lymph nodes 18.84 10.31 35 627578 8682 63862437
Anterior spinal artery syndrome 18.79 10.31 12 627601 91 63871028
Tenosynovitis 18.78 10.31 56 627557 11777 63859342
Upper respiratory tract infection 18.70 10.31 877 626736 71908 63799211
Peripheral sensory neuropathy 18.67 10.31 53 627560 11325 63859794
Bradyphrenia 18.42 10.31 40 627573 9366 63861753
Potentiating drug interaction 18.36 10.31 30 627583 7822 63863297
Dyskinesia 18.35 10.31 271 627342 39117 63832002
Vascular stent thrombosis 18.34 10.31 5 627608 3359 63867760
Injection site induration 18.32 10.31 37 627576 8895 63862224
Metastases to bone 18.25 10.31 120 627493 20315 63850804
Injection site extravasation 18.22 10.31 138 627475 7948 63863171
Gastrointestinal toxicity 18.20 10.31 15 627598 5307 63865812
Treatment failure 18.13 10.31 940 626673 115876 63755243
Hyperhidrosis 18.09 10.31 1431 626182 123489 63747630
Immunodeficiency 18.07 10.31 238 627375 15886 63855233
Eye infection 17.97 10.31 153 627460 9128 63861991
Coronary artery bypass 17.97 10.31 18 627595 5797 63865322
Pharyngeal paraesthesia 17.95 10.31 50 627563 1867 63869252
Renal cortical necrosis 17.92 10.31 18 627595 277 63870842
Hyperammonaemia 17.88 10.31 44 627569 9860 63861259
Cytomegalovirus chorioretinitis 17.87 10.31 13 627600 4899 63866220
Hot flush 17.75 10.31 582 627031 45653 63825466
Neutropenic sepsis 17.72 10.31 143 627470 23129 63847990
Sepsis 17.71 10.31 1966 625647 228375 63642744
Hypoxia 17.57 10.31 1037 626576 87112 63784007
Haematocrit decreased 17.52 10.31 674 626939 53981 63817138
Dermatitis exfoliative generalised 17.51 10.31 19 627594 5897 63865222
Eosinophil percentage increased 17.34 10.31 41 627572 1383 63869736
Ejection fraction decreased 17.30 10.31 187 627426 28520 63842599
Hyperprolactinaemia 17.23 10.31 9 627604 4056 63867063
Aplasia pure red cell 17.16 10.31 26 627587 6988 63864131
Psychomotor skills impaired 17.07 10.31 8 627605 3837 63867282
Atelectasis 17.07 10.31 366 627247 26900 63844219
Liver transplant 17.06 10.31 82 627531 4010 63867109
Torsade de pointes 17.04 10.31 99 627514 17264 63853855
Epistaxis 16.91 10.31 781 626832 97350 63773769
Alanine aminotransferase increased 16.90 10.31 1572 626041 137459 63733660
Inappropriate schedule of product administration 16.79 10.31 1077 626536 91209 63779910
Nasal congestion 16.67 10.31 725 626888 58933 63812186
Intervertebral discitis 16.59 10.31 78 627535 3779 63867340
Diffuse large B-cell lymphoma recurrent 16.55 10.31 5 627608 3141 63867978
Infusion site discomfort 16.51 10.31 28 627585 738 63870381
Fungal rhinitis 16.49 10.31 9 627604 49 63871070
JC virus infection 16.48 10.31 6 627607 3349 63867770
Haematoma 16.45 10.31 334 627279 45916 63825203
Angina unstable 16.38 10.31 86 627527 15381 63855738
Lupus vasculitis 16.34 10.31 22 627591 470 63870649
Epstein-Barr virus associated lymphoproliferative disorder 16.33 10.31 5 627608 3114 63868005
Nephrogenic systemic fibrosis 16.27 10.31 20 627593 5872 63865247
Infusion site mass 16.26 10.31 32 627581 949 63870170
Therapy interrupted 16.25 10.31 121 627492 19915 63851204
Genital haemorrhage 16.05 10.31 18 627595 5504 63865615
Incorrect dose administered by device 16.04 10.31 10 627603 4087 63867032
Aqueous fibrin 16.02 10.31 12 627601 121 63870998
Fall 16.02 10.31 3702 623911 413124 63457995
Prescribed underdose 15.98 10.31 106 627507 17909 63853210
Bladder cancer 15.97 10.31 54 627559 10920 63860199
Therapeutic response decreased 15.96 10.31 386 627227 51802 63819317
Acute coronary syndrome 15.95 10.31 116 627497 19194 63851925
Sputum culture positive 15.92 10.31 65 627548 2961 63868158
Cyst 15.85 10.31 183 627430 11844 63859275
Pancreatic carcinoma 15.82 10.31 50 627563 10323 63860796
Granulomatosis with polyangiitis 15.79 10.31 51 627562 2069 63869050
Mental status changes 15.72 10.31 737 626876 60425 63810694
Toxicologic test abnormal 15.71 10.31 36 627577 1189 63869930
Scoliosis 15.55 10.31 107 627506 5975 63865144
Pulse absent 15.53 10.31 144 627469 8802 63862317
Rash pustular 15.53 10.31 47 627566 9838 63861281
Sudden death 15.53 10.31 123 627490 19973 63851146
Lip pruritus 15.50 10.31 26 627587 679 63870440
Nitrite urine present 15.44 10.31 33 627580 1039 63870080
Soft tissue disorder 15.40 10.31 68 627545 3208 63867911
Neuralgia 15.29 10.31 348 627265 25836 63845283
Dystonia 15.26 10.31 114 627499 18751 63852368
Pneumonia cytomegaloviral 15.13 10.31 12 627601 4327 63866792
Injection site mass 15.13 10.31 102 627511 17168 63853951
Hyperthyroidism 15.12 10.31 109 627504 18070 63853049
Retinal vasculitis 15.04 10.31 34 627579 1113 63870006
Anterior chamber cell 15.03 10.31 28 627585 796 63870323
Respiratory disorder 15.03 10.31 459 627154 35652 63835467
Pemphigoid 15.02 10.31 70 627543 12916 63858203
Gastric cancer 15.00 10.31 25 627588 6468 63864651
Withdrawal syndrome 14.98 10.31 151 627462 23341 63847778
Cough 14.97 10.31 3241 624372 298907 63572212
Secondary immunodeficiency 14.94 10.31 4 627609 2720 63868399
Abnormal loss of weight 14.88 10.31 31 627582 7369 63863750
Bronchospasm 14.87 10.31 295 627318 21387 63849732
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.86 10.31 5 627608 2931 63868188
Oculocardiac reflex 14.79 10.31 9 627604 62 63871057
Femoral neck fracture 14.79 10.31 40 627573 8684 63862435
Affective disorder 14.60 10.31 26 627587 6554 63864565
Post-traumatic stress disorder 14.56 10.31 80 627533 4125 63866994
Ketoacidosis 14.44 10.31 28 627585 6835 63864284
Cytomegalovirus infection reactivation 14.41 10.31 21 627592 5735 63865384
Sudden cardiac death 14.40 10.31 14 627599 4573 63866546
Infusion site bruising 14.39 10.31 40 627573 1492 63869627
Nerve block 14.38 10.31 18 627595 357 63870762
Partial seizures 14.37 10.31 31 627582 7276 63863843
Gastroenteritis 14.33 10.31 203 627410 29508 63841611
Drug withdrawal syndrome 14.33 10.31 216 627397 31075 63840044
Hemiparesis 14.32 10.31 204 627409 29623 63841496
Nerve root injury 14.31 10.31 7 627606 29 63871090
Vital capacity decreased 14.30 10.31 32 627581 1040 63870079
Pharyngitis streptococcal 14.29 10.31 138 627475 8530 63862589
Tubulointerstitial nephritis 14.28 10.31 213 627400 30696 63840423
Smear cervix abnormal 14.11 10.31 53 627560 2321 63868798
Epigastric discomfort 14.11 10.31 114 627499 6697 63864422
Nephropathy toxic 14.09 10.31 106 627507 17408 63853711
Concomitant disease aggravated 14.08 10.31 61 627552 11481 63859638
Device leakage 13.94 10.31 38 627575 8228 63862891
Tendonitis 13.94 10.31 128 627485 20154 63850965
Blood pressure decreased 13.91 10.31 996 626617 85203 63785916
Electrolyte imbalance 13.82 10.31 168 627445 25075 63846044
Haemorrhage 13.78 10.31 631 626982 78720 63792399
Mean arterial pressure decreased 13.78 10.31 17 627596 332 63870787
Injection site rash 13.77 10.31 93 627520 15649 63855470
Spinal meningioma benign 13.75 10.31 10 627603 96 63871023
Device difficult to use 13.73 10.31 49 627564 9749 63861370
Procedural hypotension 13.71 10.31 45 627568 1841 63869278
Constipation 13.71 10.31 2483 625130 226854 63644265
Dermatitis exfoliative 13.70 10.31 53 627560 10299 63860820
Sedation 13.69 10.31 513 627100 40949 63830170
Neovascularisation 13.69 10.31 32 627581 1071 63870048
Limb mass 13.67 10.31 62 627551 2959 63868160
Acute myeloid leukaemia recurrent 13.64 10.31 5 627608 2779 63868340
Lung neoplasm malignant 13.62 10.31 138 627475 21310 63849809
Rhinorrhoea 13.62 10.31 714 626899 59255 63811864
Salivary hypersecretion 13.60 10.31 66 627547 12047 63859072
Hypothyroidism 13.56 10.31 295 627318 40162 63830957
Organising pneumonia 13.56 10.31 44 627569 9011 63862108
COVID-19 immunisation 13.55 10.31 22 627591 559 63870560
Infusion site haematoma 13.51 10.31 14 627599 224 63870895
Incorrect dose administered 13.50 10.31 722 626891 60043 63811076
Urobilinogen urine increased 13.49 10.31 23 627590 609 63870510
Hypogammaglobulinaemia 13.46 10.31 53 627560 10246 63860873
Progressive multifocal leukoencephalopathy 13.44 10.31 113 627500 18119 63853000
Circulatory collapse 13.41 10.31 239 627374 33493 63837626
Cestode infection 13.40 10.31 15 627598 263 63870856
Sudden infant death syndrome 13.37 10.31 12 627601 159 63870960
Dermatitis allergic 13.35 10.31 89 627524 15020 63856099
Hypertension 13.33 10.31 2786 624827 256475 63614644
Influenza 13.32 10.31 1207 626406 105324 63765795
Nephrotic syndrome 13.30 10.31 48 627565 9519 63861600
Migraine with aura 13.24 10.31 51 627562 2261 63868858
Jaundice 13.19 10.31 365 627248 48147 63822972
Cell death 13.17 10.31 12 627601 4042 63867077
Device dislocation 13.15 10.31 137 627476 21041 63850078
Psychotic disorder 13.12 10.31 247 627366 34331 63836788
Injection site urticaria 13.09 10.31 60 627553 11121 63859998
Abdominal discomfort 13.02 10.31 1993 625620 180329 63690790
Pharyngeal disorder 12.98 10.31 44 627569 1831 63869288
Renal tubular disorder 12.98 10.31 24 627589 5963 63865156
Hepatitis C 12.96 10.31 59 627554 10956 63860163
Urine bilirubin decreased 12.94 10.31 11 627602 135 63870984
Concussion 12.90 10.31 126 627487 7812 63863307
Drug level below therapeutic 12.89 10.31 119 627494 7265 63863854
Band neutrophil count increased 12.89 10.31 23 627590 632 63870487
Drug dose omission by device 12.77 10.31 9 627604 3448 63867671
Weight fluctuation 12.75 10.31 130 627483 8152 63862967
Osmolar gap 12.74 10.31 11 627602 138 63870981
Arrhythmia 12.73 10.31 405 627208 52539 63818580
PCO2 decreased 12.71 10.31 59 627554 2843 63868276
Obsessive-compulsive disorder 12.64 10.31 17 627596 4801 63866318
Transplant failure 12.60 10.31 11 627602 3783 63867336
Blood uric acid decreased 12.56 10.31 31 627582 1075 63870044
Product tampering 12.54 10.31 13 627600 208 63870911
Hernia 12.54 10.31 193 627420 13325 63857794
Infusion site urticaria 12.47 10.31 22 627591 599 63870520
Psoriatic arthropathy 12.45 10.31 323 627290 42958 63828161
Prerenal failure 12.43 10.31 8 627605 3214 63867905
Precancerous cells present 12.38 10.31 29 627584 972 63870147
Upper gastrointestinal haemorrhage 12.33 10.31 255 627358 34965 63836154
Multiple drug therapy 12.32 10.31 49 627564 2205 63868914
pH urine increased 12.32 10.31 18 627595 416 63870703
Brain stem glioma 12.30 10.31 11 627602 145 63870974
Delusion 12.24 10.31 114 627499 17900 63853219
Osteopenia 12.24 10.31 216 627397 15324 63855795
Bone cyst 12.20 10.31 48 627565 2149 63868970
Catatonia 12.14 10.31 36 627577 7584 63863535
Polyomavirus-associated nephropathy 12.07 10.31 18 627595 4870 63866249
Poor quality sleep 12.06 10.31 255 627358 18696 63852423
Aspartate aminotransferase increased 12.05 10.31 1337 626276 118451 63752668
Skin laceration 12.00 10.31 317 627296 24100 63847019
Transferrin decreased 12.00 10.31 15 627598 297 63870822
Cerebral ischaemia 11.94 10.31 53 627560 9909 63861210
Cutaneous T-cell lymphoma 11.91 10.31 4 627609 2348 63868771
Atypical femur fracture 11.90 10.31 17 627596 4681 63866438
Acidosis 11.84 10.31 241 627372 17554 63853565
Metastases to central nervous system 11.77 10.31 83 627530 13829 63857290
Rash pruritic 11.76 10.31 448 627165 56956 63814163
Adenovirus infection 11.76 10.31 34 627579 7221 63863898
Seizure 11.73 10.31 1433 626180 165459 63705660
Stomatitis 11.67 10.31 1228 626385 108377 63762742
Subileus 11.65 10.31 19 627594 4958 63866161
Tooth disorder 11.64 10.31 293 627320 22109 63849010
Coma 11.62 10.31 997 626616 86618 63784501
Post procedural complication 11.61 10.31 281 627332 21072 63850047
Tri-iodothyronine free increased 11.61 10.31 13 627600 228 63870891
Persecutory delusion 11.60 10.31 14 627599 4144 63866975
Monocyte count increased 11.59 10.31 125 627488 7954 63863165
Autonomic dysreflexia 11.54 10.31 17 627596 396 63870723
Anal sphincter atony 11.51 10.31 15 627598 310 63870809
Pleurothotonus 11.51 10.31 4 627609 2298 63868821
Meningitis chemical 11.48 10.31 12 627601 194 63870925
Trigemino-cardiac reflex 11.48 10.31 13 627600 231 63870888
Tryptase increased 11.47 10.31 18 627595 444 63870675
Pericardial haemorrhage 11.46 10.31 14 627599 4122 63866997
Illness 11.42 10.31 287 627326 21651 63849468
Therapy partial responder 11.41 10.31 56 627557 10192 63860927
Administration site swelling 11.37 10.31 15 627598 314 63870805
Viral load increased 11.32 10.31 5 627608 2482 63868637
Band sensation 11.30 10.31 22 627591 647 63870472
Pneumatosis intestinalis 11.30 10.31 21 627592 5208 63865911
Ear infection 11.26 10.31 303 627310 23101 63848018
Underdose 11.25 10.31 180 627433 25649 63845470
White blood cells urine 11.20 10.31 16 627597 362 63870757
Polydipsia 11.20 10.31 25 627588 5796 63865323
Respiratory failure 11.20 10.31 1385 626228 159798 63711321
Drug tolerance decreased 11.19 10.31 33 627580 6965 63864154
Multiple sclerosis 11.14 10.31 252 627361 18689 63852430
Premenstrual syndrome 11.09 10.31 19 627594 505 63870614
Extradural abscess 11.09 10.31 31 627582 1160 63869959
Red blood cell spherocytes present 11.09 10.31 6 627607 32 63871087
Renal pain 10.99 10.31 110 627503 6864 63864255
Anti-erythrocyte antibody positive 10.98 10.31 8 627605 77 63871042
Tuberculosis 10.93 10.31 78 627535 12960 63858159
Penile vascular disorder 10.93 10.31 3 627610 0 63871119
Upper-airway cough syndrome 10.92 10.31 132 627481 8638 63862481
Hypovolaemic shock 10.92 10.31 57 627556 10209 63860910
Acute lymphocytic leukaemia 10.89 10.31 16 627597 4355 63866764
Hepatitis E 10.89 10.31 5 627608 2426 63868693
Hyperlactacidaemia 10.87 10.31 19 627594 4825 63866294
Pupil fixed 10.86 10.31 61 627552 3171 63867948
B-cell lymphoma 10.86 10.31 23 627590 5434 63865685
International normalised ratio increased 10.83 10.31 903 626710 78264 63792855
Obesity 10.82 10.31 138 627475 20424 63850695
Atonic urinary bladder 10.82 10.31 8 627605 79 63871040
Product adhesion issue 10.78 10.31 50 627563 2409 63868710
Iron deficiency anaemia 10.76 10.31 149 627464 21740 63849379
Mydriasis 10.73 10.31 209 627404 15103 63856016
Red cell distribution width decreased 10.73 10.31 29 627584 1064 63870055
Cerebral haematoma 10.70 10.31 35 627578 7150 63863969
Laryngeal stenosis 10.67 10.31 24 627589 783 63870336
Stent placement 10.66 10.31 24 627589 5547 63865572
Cardiomyopathy 10.62 10.31 178 627435 25178 63845941
Decerebrate posture 10.61 10.31 11 627602 176 63870943
Dysponesis 10.59 10.31 4 627609 7 63871112
Vein collapse 10.55 10.31 21 627592 628 63870491
Colitis microscopic 10.52 10.31 37 627576 7395 63863724
Infusion site rash 10.51 10.31 29 627584 1077 63870042
Oral pruritus 10.49 10.31 40 627573 1765 63869354
Mean cell haemoglobin increased 10.48 10.31 60 627553 3142 63867977
Arteriovenous fistula occlusion 10.45 10.31 19 627594 530 63870589
Rebound effect 10.40 10.31 20 627593 4897 63866222
Environmental exposure 10.38 10.31 15 627598 343 63870776
Pneumocystis jirovecii infection 10.35 10.31 5 627608 2356 63868763

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC R01AA04 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R01AB01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, combinations excl. corticosteroids
ATC R01BA03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC S01FB01 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01FB51 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01GA05 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
ATC S01GA55 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
FDA MoA N0000009917 Adrenergic alpha1-Agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058646 Adrenergic alpha-1 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D014663 Nasal Decongestants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50513 mydriatics
CHEBI has role CHEBI:77715 nasal decongestants
FDA EPC N0000186105 alpha-1 Adrenergic Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Dilated pupil indication 37125009
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Hemorrhoids indication 70153002 DOID:9746
Red eye indication 75705005
Sneezing indication 76067001
Rectal pain indication 77880009
Common cold indication 82272006 DOID:10459
Pruritus ani indication 90446007
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Fever indication 386661006
Allergic conjunctivitis indication 473460002 DOID:11204
Prevention of Posterior Synechiae indication
Priapism off-label use 6273006 DOID:9286
Low blood pressure off-label use 45007003
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Anxiety contraindication 48694002
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Perforation of tympanic membrane contraindication 60442001
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Arterial aneurysm contraindication 233981004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Bone marrow depression contraindication 307762000
Infective otitis media contraindication 312218008
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Predisposition to Glaucoma contraindication
Nervousness contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.15 acidic
pKa2 13.64 acidic
pKa3 8.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.3% BASE;EQ 1% BASE OMIDRIA RAYNER SURGICAL N205388 May 30, 2014 RX SOLUTION IRRIGATION 8173707 July 30, 2023 MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN
EQ 0.3% BASE;EQ 1% BASE OMIDRIA RAYNER SURGICAL N205388 May 30, 2014 RX SOLUTION IRRIGATION 9278101 July 30, 2023 MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN
10% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL
2.5% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.30 WOMBAT-PK CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST IC50 5.90 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 6.90 WOMBAT-PK CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.41 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.89 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.03 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.90 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.57 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.21 CHEMBL
Alpha-1B adrenergic receptor GPCR EC50 8 CHEMBL

External reference:

IDSource
4017847 VUID
N0000146204 NUI
D00511 KEGG_DRUG
61-76-7 SECONDARY_CAS_RN
1416-03-1 SECONDARY_CAS_RN
17162-39-9 SECONDARY_CAS_RN
4017845 VANDF
4017847 VANDF
4018447 VANDF
4018824 VANDF
C0031469 UMLSCUI
CHEBI:8093 CHEBI
CHEMBL1215 ChEMBL_ID
DB00388 DRUGBANK_ID
CHEMBL1200339 ChEMBL_ID
CHEMBL2062264 ChEMBL_ID
D010656 MESH_DESCRIPTOR_UI
6041 PUBCHEM_CID
4174 INN_ID
485 IUPHAR_LIGAND_ID
1WS297W6MV UNII
221139 RXNORM
1307 MMSL
30342 MMSL
35410 MMSL
5282 MMSL
5283 MMSL
5284 MMSL
5285 MMSL
d00704 MMSL
001825 NDDF
001826 NDDF
001827 NDDF
001828 NDDF
372771005 SNOMEDCT_US
54765002 SNOMEDCT_US
68699004 SNOMEDCT_US
73946006 SNOMEDCT_US
784324003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fresh Clear HUMAN PRESCRIPTION DRUG LABEL 1 0023-0000 SOLUTION/ DROPS 1.20 mg OPHTHALMIC Export only 1 sections
CHILDRENS DIMETAPP COLD AND COUGH HUMAN OTC DRUG LABEL 3 0031-2234 LIQUID 2.50 mg ORAL OTC monograph final 16 sections
CHILDRENS DIMETAPP COLD AND ALLERGY HUMAN OTC DRUG LABEL 2 0031-2235 LIQUID 2.50 mg ORAL OTC monograph final 16 sections
Childrens Dimetapp Multi-Symptom Cold and Flu HUMAN OTC DRUG LABEL 3 0031-2249 LIQUID 5 mg ORAL Unapproved drug other 17 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 2.50 mg ORAL OTC monograph final 16 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 5 mg ORAL OTC MONOGRAPH FINAL 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-0924 POWDER 10 mg ORAL Export only 10 sections
4 WayFast Acting HUMAN OTC DRUG LABEL 1 0067-2086 SPRAY 10 mg NASAL OTC monograph final 14 sections
TherafluPowerPods Daytime Severe Cold HUMAN OTC DRUG LABEL 3 0067-6094 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUPOWERPODS NIGHTTIME SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6095 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUMULTI-SYMPTOM SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6426 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
TherafluFlu and Sore Throat HUMAN OTC DRUG LABEL 3 0067-7916 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
TherafluDaytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-7917 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUNIGHTTIME SEVERE COLD AND COUGH HUMAN OTC DRUG LABEL 3 0067-7918 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
THERAFLUSINUS AND PAIN HUMAN OTC DRUG LABEL 3 0067-7920 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
THERAFLUSINUS AND PAIN HUMAN OTC DRUG LABEL 3 0067-7920 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
TriaminicDay Time Cold and Cough HUMAN OTC DRUG LABEL 2 0067-8105 SYRUP 2.50 mg ORAL OTC monograph final 14 sections
TRIAMINICNight Time Cold and Cough HUMAN OTC DRUG LABEL 2 0067-8106 SYRUP 2.50 mg ORAL OTC monograph final 15 sections
TriaminicMulti-Symptom Fever and Cold HUMAN OTC DRUG LABEL 4 0067-8116 SUSPENSION 2.50 mg ORAL OTC monograph final 15 sections
Theraflu Nighttime Multi-Symptom Severe Cold Powder HUMAN OTC DRUG LABEL 3 0067-8124 POWDER 10 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMaxDaytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8127 SYRUP 10 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMaxDaytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8127 SYRUP 10 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMaxNighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8129 SYRUP 10 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMaxNighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8129 SYRUP 10 mg ORAL OTC monograph final 16 sections
Theraflu ExpressMax Severe Cold and Flu Syrup HUMAN OTC DRUG LABEL 4 0067-8132 SYRUP 10 mg ORAL OTC monograph final 16 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-8135 POWDER 10 mg ORAL Export only 15 sections