phenylephrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 2146 59-42-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (-)-Phenylephrine
  • (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • (-)-m-Oxedrine
  • (-)-m-Synephrine
  • (R)-Phenylephrine
  • L-Phenylephedrine
  • mesatone
  • metaoxedrin
  • metaoxedrine
  • metasympatol
  • metasynephrine
  • mezaton
  • l-Phenylephrine
  • phenylephrine
  • phenylephrine hydrochloride
  • phenylephrine tannate
  • phenylephrine bitartrate
  • phenylephrine HCl
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
  • Molecular weight: 167.21
  • Formula: C9H13NO2
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -0.88
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg P
4 mg N
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.98 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1226.96 10.75 5843 721399 241407 62520373
Completed suicide 1147.69 10.75 3975 723267 141698 62620082
Exposure to toxic agent 686.52 10.75 545 726697 5042 62756738
Infusion related reaction 613.21 10.75 4859 722383 240662 62521118
Sinusitis 507.55 10.75 4377 722865 222276 62539504
Acute hepatic failure 460.51 10.75 785 726457 17542 62744238
Blood pressure fluctuation 415.05 10.75 1321 725921 44996 62716784
Muscle injury 283.99 10.75 1489 725753 63856 62697924
Irritable bowel syndrome 276.49 10.75 1753 725489 80659 62681121
Folliculitis 275.74 10.75 1558 725684 68759 62693021
Intentional overdose 266.15 10.75 1605 725637 72547 62689233
Overdose 244.55 10.75 2198 725044 112880 62648900
Lower respiratory tract infection 242.44 10.75 2449 724793 129858 62631922
Nasopharyngitis 240.98 10.75 4172 723070 250085 62511695
Intentional product misuse 239.01 10.75 1350 725892 59567 62702213
Device expulsion 230.10 10.75 58 727184 34864 62726916
Drug interaction 215.98 10.75 1636 725606 227495 62534285
Injection site pain 206.57 10.75 776 726466 129024 62632756
Drug ineffective 200.22 10.75 9862 717380 1034903 61726877
Ill-defined disorder 199.20 10.75 1610 725632 80145 62681635
Local anaesthetic systemic toxicity 192.38 10.75 123 727119 776 62761004
Metabolic acidosis 191.01 10.75 1020 726222 44049 62717731
Analgesic drug level increased 185.65 10.75 179 727063 2193 62759587
Blister 181.10 10.75 2278 724964 127536 62634244
Sleep disorder due to general medical condition, insomnia type 180.87 10.75 1120 726122 51097 62710683
Blood pressure increased 180.19 10.75 2731 724511 159331 62602449
Rheumatoid arthritis 179.27 10.75 3984 723258 249835 62511945
Anaemia 176.66 10.75 2334 724908 291096 62470684
Anion gap 173.76 10.75 134 727108 1183 62760597
Hepatic cytolysis 172.83 10.75 476 726766 14931 62746849
Blood pressure diastolic abnormal 163.85 10.75 450 726792 14092 62747688
Body temperature increased 151.70 10.75 833 726409 36359 62725421
Hepatotoxicity 151.34 10.75 830 726412 36211 62725569
Cardiac failure 151.04 10.75 519 726723 88623 62673157
Duodenal ulcer perforation 148.67 10.75 1591 725651 85618 62676162
Helicobacter infection 148.20 10.75 1671 725571 91114 62670666
Neutropenia 148.10 10.75 1286 725956 173719 62588061
Heart rate decreased 145.31 10.75 957 726285 44603 62717177
Blood pressure systolic increased 142.43 10.75 981 726261 46416 62715364
Blood pressure systolic abnormal 141.75 10.75 405 726837 12981 62748799
Injection site erythema 141.09 10.75 484 726758 82690 62679090
Impaired healing 140.25 10.75 1793 725449 100749 62661031
Drug resistance 140.10 10.75 44 727198 22889 62738891
Throat irritation 137.67 10.75 819 726423 36828 62724952
Oxygen saturation decreased 137.26 10.75 1586 725656 86999 62674781
Heart rate increased 134.08 10.75 1660 725582 92578 62669202
Sopor 132.79 10.75 44 727198 22120 62739660
Weight increased 130.61 10.75 3911 723331 256881 62504899
Pancytopenia 128.64 10.75 621 726621 96312 62665468
Malignant neoplasm progression 126.72 10.75 497 726745 81624 62680156
Wrong technique in product usage process 124.87 10.75 336 726906 62004 62699776
Intentional product use issue 123.65 10.75 2106 725136 125786 62635994
Gastrointestinal disorder 117.19 10.75 2134 725108 129105 62632675
Hyponatraemia 115.51 10.75 778 726464 111122 62650658
Osteonecrosis of jaw 112.49 10.75 142 727100 34981 62726799
Ear pain 112.36 10.75 754 726488 35364 62726416
Bone marrow failure 112.10 10.75 102 727140 29188 62732592
Infusion site pain 111.26 10.75 435 726807 16434 62745346
Peripheral swelling 110.55 10.75 3901 723341 262041 62499739
Hepatic enzyme increased 108.86 10.75 3062 724180 199266 62562514
Injection site reaction 107.99 10.75 328 726914 58196 62703584
Blood pressure diastolic decreased 104.59 10.75 526 726716 22180 62739600
Medication error 103.10 10.75 983 726259 51301 62710479
Joint swelling 99.39 10.75 4647 722595 323019 62438761
Acute kidney injury 98.29 10.75 2282 724960 261133 62500647
Anti-cyclic citrullinated peptide antibody positive 97.97 10.75 1873 725369 114339 62647441
Thrombocytopenia 97.28 10.75 1185 726057 149972 62611808
Pericarditis 95.50 10.75 2074 725168 129505 62632275
Infusion site swelling 92.41 10.75 284 726958 9486 62752294
Infusion site extravasation 92.12 10.75 296 726946 10130 62751650
Psoriasis 91.03 10.75 602 726640 86355 62675425
Muscle spasticity 90.80 10.75 491 726751 21303 62740477
Leukopenia 89.78 10.75 518 726724 76772 62685008
Coagulopathy 88.43 10.75 467 726775 20077 62741703
Abortion spontaneous 88.16 10.75 263 726979 46932 62714848
Disease progression 87.73 10.75 940 726302 121818 62639962
Stomatitis 86.87 10.75 2142 725100 136583 62625197
COVID-19 86.34 10.75 1796 725446 111307 62650473
Myelosuppression 85.52 10.75 87 727155 23616 62738164
Product dose omission issue 85.14 10.75 2038 725204 232275 62529505
Pruritus 84.73 10.75 5003 722239 356450 62405330
Blood parathyroid hormone decreased 80.46 10.75 9 727233 9782 62751998
Injection site pruritus 80.30 10.75 257 726985 44859 62716921
Infusion site erythema 80.16 10.75 305 726937 11374 62750406
Hyperkalaemia 79.86 10.75 334 726908 53869 62707911
Urine leukocyte esterase positive 79.18 10.75 145 727097 3434 62758346
Interstitial lung disease 79.03 10.75 402 726840 61506 62700274
Cardiac failure congestive 78.23 10.75 679 726563 91754 62670026
Hypersensitivity 77.51 10.75 4097 723145 288588 62473192
Depressed level of consciousness 77.18 10.75 1067 726175 61011 62700769
Toxic anterior segment syndrome 76.64 10.75 98 727144 1673 62760107
Injection site bruising 76.52 10.75 236 727006 41674 62720106
Diarrhoea 76.37 10.75 7107 720135 708259 62053521
Septic shock 76.08 10.75 449 726793 66180 62695600
Hypokalaemia 75.73 10.75 791 726451 103013 62658767
Urine abnormality 73.96 10.75 212 727030 6807 62754973
Sedation complication 73.67 10.75 334 726908 13488 62748292
Drug hypersensitivity 71.76 10.75 2870 724372 307817 62453963
Infusion site pruritus 70.23 10.75 189 727053 5846 62755934
Hypocalcaemia 68.07 10.75 165 727077 31548 62730232
Suicide attempt 67.78 10.75 1027 726215 59891 62701889
Red blood cell sedimentation rate abnormal 67.59 10.75 76 727166 19706 62742074
Renal impairment 66.21 10.75 669 726573 87686 62674094
Blood pressure diastolic increased 65.91 10.75 258 726984 9752 62752028
Mucosal inflammation 65.57 10.75 295 726947 46633 62715147
Haematotoxicity 64.88 10.75 14 727228 9362 62752418
Injection site swelling 64.72 10.75 302 726940 47270 62714510
Ear pruritus 63.03 10.75 140 727102 3825 62757955
Respiratory depression 62.66 10.75 317 726925 13398 62748382
Granuloma skin 61.74 10.75 11 727231 8426 62753354
Pyroglutamic acidosis 61.53 10.75 54 727188 581 62761199
Panniculitis 60.90 10.75 27 727215 11358 62750422
Cytomegalovirus infection 60.76 10.75 91 727151 20861 62740919
Creatinine renal clearance decreased 60.40 10.75 356 726886 15952 62745828
Maternal exposure during delivery 60.24 10.75 80 727162 1420 62760360
Urticaria 60.12 10.75 2396 724846 163406 62598374
Hospitalisation 58.97 10.75 656 726586 84425 62677355
Lactic acidosis 58.86 10.75 232 727010 38055 62723725
Acute lung injury 58.85 10.75 81 727161 1490 62760290
Headache 58.74 10.75 8191 719051 625050 62136730
Therapeutic product effect decreased 58.72 10.75 2741 724501 190446 62571334
Epilepsy 57.95 10.75 141 727101 26924 62734856
Blood calcium decreased 57.55 10.75 508 726734 25943 62735837
Therapeutic response decreased 57.53 10.75 440 726802 61085 62700695
Myocardial infarction 56.94 10.75 803 726439 99090 62662690
Poor venous access 56.87 10.75 326 726916 14459 62747321
Posterior reversible encephalopathy syndrome 56.72 10.75 69 727173 17276 62744504
Poisoning deliberate 56.05 10.75 266 726976 10952 62750828
Product prescribing error 53.92 10.75 140 727102 26149 62735631
Product substitution issue 51.92 10.75 64 727178 15932 62745848
Skin necrosis 51.71 10.75 50 727192 13900 62747880
Therapy cessation 51.11 10.75 178 727064 30279 62731501
Foetal exposure during pregnancy 50.86 10.75 191 727051 31771 62730009
Palmar-plantar erythrodysaesthesia syndrome 50.79 10.75 118 727124 22897 62738883
White blood cells urine positive 50.72 10.75 152 727090 5006 62756774
Weight fluctuation 50.65 10.75 235 727007 9584 62752196
Night sweats 50.14 10.75 812 726430 48002 62713778
Urinary sediment present 49.68 10.75 90 727152 2113 62759667
Renal failure 49.67 10.75 999 726243 116653 62645127
Infection 49.67 10.75 3151 724091 226022 62535758
Device dislocation 49.64 10.75 141 727101 25564 62736216
Pneumocystis jirovecii pneumonia 49.50 10.75 73 727169 16841 62744939
Heart rate irregular 48.98 10.75 431 726811 21990 62739790
Bronchial secretion retention 48.77 10.75 102 727140 2671 62759109
Arthralgia 48.67 10.75 7335 719907 562375 62199405
Drug eruption 47.95 10.75 168 727074 28526 62733254
Pyroglutamate increased 47.82 10.75 40 727202 401 62761379
Device malfunction 47.60 10.75 82 727160 17775 62744005
Hypercalcaemia 47.21 10.75 166 727076 28156 62733624
Agranulocytosis 46.98 10.75 140 727102 24994 62736786
Device adhesion issue 46.96 10.75 3 727239 5138 62756642
Transplant rejection 46.94 10.75 33 727209 10747 62751033
Neoplasm progression 46.80 10.75 236 727006 36192 62725588
Breast cancer stage I 46.24 10.75 11 727231 6878 62754902
Contusion 45.60 10.75 2129 725113 147915 62613865
Rheumatoid nodule 45.53 10.75 79 727163 17076 62744704
Myelodysplastic syndrome 45.52 10.75 76 727166 16678 62745102
Diabetic ketoacidosis 45.35 10.75 105 727137 20400 62741380
Therapeutic product effect incomplete 45.01 10.75 1089 726153 123967 62637813
Diabetes mellitus 45.01 10.75 415 726827 55395 62706385
Respiratory arrest 44.67 10.75 571 726671 32074 62729706
Thrombotic microangiopathy 43.83 10.75 34 727208 10527 62751253
Red blood cells urine positive 43.77 10.75 105 727137 3021 62758759
Infusion site haemorrhage 43.67 10.75 143 727099 4943 62756837
Hepatic necrosis 43.65 10.75 154 727088 5533 62756247
Product storage error 43.33 10.75 65 727177 14891 62746889
Breast cancer female 43.22 10.75 55 727187 13504 62748276
Incorrect drug administration rate 43.05 10.75 121 727121 3841 62757939
Surgery 42.60 10.75 239 727003 35673 62726107
Respiratory disorder 42.36 10.75 656 726586 38426 62723354
Decreased appetite 42.24 10.75 2398 724844 248654 62513126
Kounis syndrome 42.01 10.75 73 727169 1657 62760123
Back pain 41.93 10.75 3542 723700 260603 62501177
Anion gap abnormal 41.57 10.75 36 727206 380 62761400
Osteonecrosis 41.41 10.75 143 727099 24387 62737393
Inappropriate schedule of product administration 40.89 10.75 1516 725726 102449 62659331
Lymphocyte count decreased 40.88 10.75 528 726714 29729 62732051
Post transplant lymphoproliferative disorder 40.41 10.75 5 727237 5026 62756754
Temperature regulation disorder 40.33 10.75 158 727084 5974 62755806
Swelling 40.05 10.75 3669 723573 271709 62490071
Pathogen resistance 39.58 10.75 12 727230 6386 62755394
Electric shock 39.21 10.75 61 727181 1259 62760521
Crystal urine present 39.13 10.75 69 727173 1585 62760195
Infusion site bruising 38.70 10.75 114 727128 3718 62758062
Unintentional medical device removal 38.68 10.75 11 727231 6104 62755676
Seizure 38.66 10.75 1190 726052 131444 62630336
Injection site warmth 38.51 10.75 72 727170 15123 62746657
Genital haemorrhage 38.26 10.75 18 727224 7314 62754466
Suicidal ideation 38.01 10.75 495 726747 61926 62699854
Hyperglycaemia 37.93 10.75 302 726940 41565 62720215
Alopecia 37.91 10.75 3339 723903 334197 62427583
Basal cell carcinoma 37.89 10.75 178 727064 27813 62733967
Hepatic failure 37.70 10.75 596 726646 35060 62726720
Discomfort 37.66 10.75 2309 724933 165065 62596715
Oedema peripheral 37.60 10.75 1780 725462 187731 62574049
Accidental exposure to product 37.26 10.75 174 727068 27231 62734549
Polyneuropathy 37.08 10.75 69 727173 14520 62747260
Platelet count decreased 37.06 10.75 1029 726213 115093 62646687
Injection site haemorrhage 36.95 10.75 148 727094 24166 62737614
Therapy interrupted 36.89 10.75 219 727023 32236 62729544
Respiratory rate increased 36.66 10.75 275 726967 13373 62748407
Systemic infection 36.54 10.75 5 727237 4655 62757125
Metastases to bone 36.52 10.75 121 727121 20898 62740882
Bursitis 36.50 10.75 612 726630 36429 62725351
Metastases to liver 36.49 10.75 143 727099 23496 62738284
Drug withdrawal syndrome 36.18 10.75 174 727068 27020 62734760
Accidental overdose 35.93 10.75 417 726825 22892 62738888
Gastrointestinal haemorrhage 35.86 10.75 684 726558 80492 62681288
Illness 35.46 10.75 773 726469 48286 62713494
Metastases to lung 35.42 10.75 57 727185 12693 62749087
Flushing 35.08 10.75 1117 726125 73970 62687810
Device difficult to use 34.81 10.75 58 727184 12738 62749042
Cerebral infarction 34.71 10.75 148 727094 23745 62738035
Blood urine present 34.66 10.75 293 726949 14776 62747004
No adverse event 34.21 10.75 306 726936 41099 62720681
General physical health deterioration 34.18 10.75 1922 725320 199480 62562300
Synovitis 33.97 10.75 2533 724709 184385 62577395
Febrile bone marrow aplasia 33.82 10.75 21 727221 7304 62754476
Confusional state 33.69 10.75 3145 724097 233235 62528545
Ascites 33.65 10.75 301 726941 40427 62721353
Urine analysis abnormal 33.61 10.75 130 727112 4886 62756894
Body temperature fluctuation 33.35 10.75 78 727164 2207 62759573
Multiple organ dysfunction syndrome 33.12 10.75 454 726788 56298 62705482
Food allergy 33.08 10.75 234 727008 11167 62750613
Oropharyngeal pain 32.97 10.75 1360 725882 93127 62668653
Inappropriate antidiuretic hormone secretion 32.75 10.75 81 727161 15381 62746399
Intentional self-injury 32.66 10.75 167 727075 25520 62736260
Femur fracture 32.60 10.75 313 726929 41443 62720337
Red cell distribution width increased 32.30 10.75 219 727023 10305 62751475
Transplant dysfunction 32.27 10.75 8 727234 4864 62756916
Therapeutic response shortened 32.19 10.75 240 727002 11648 62750132
Psoriatic arthropathy 32.10 10.75 800 726442 90720 62671060
Fracture 31.83 10.75 116 727126 19468 62742312
Chest discomfort 31.63 10.75 1552 725690 108417 62653363
Rhabdomyolysis 31.60 10.75 336 726906 43615 62718165
Hypomagnesaemia 31.57 10.75 196 727046 28541 62733239
Neuroleptic malignant syndrome 31.56 10.75 56 727186 12000 62749780
Akathisia 31.40 10.75 35 727207 9111 62752669
Syncope 31.38 10.75 1065 726177 116320 62645460
Cognitive disorder 31.17 10.75 849 726393 54966 62706814
Cerebrovascular accident 31.03 10.75 971 726271 107053 62654727
Haemophagocytic lymphohistiocytosis 30.97 10.75 46 727196 10581 62751199
Cardio-respiratory arrest 30.96 10.75 903 726339 59056 62702724
Lymphocyte percentage decreased 30.34 10.75 89 727153 2896 62758884
Device use error 30.29 10.75 14 727228 5747 62756033
Injection site rash 30.18 10.75 112 727130 18697 62743083
Suspected suicide 30.14 10.75 152 727090 6416 62755364
Respiratory failure 30.13 10.75 912 726330 100946 62660834
Second primary malignancy 30.07 10.75 28 727214 7925 62753855
Hepatocellular injury 29.95 10.75 187 727055 27194 62734586
Chills 29.92 10.75 1587 725655 111791 62649989
Vital capacity decreased 29.74 10.75 63 727179 1665 62760115
Multiple-drug resistance 29.71 10.75 11 727231 5159 62756621
Sputum culture positive 29.50 10.75 72 727170 2095 62759685
Body temperature decreased 29.34 10.75 359 726883 19960 62741820
Underdose 29.26 10.75 189 727053 27267 62734513
Rheumatic fever 29.19 10.75 673 726569 42438 62719342
Hypotension 29.17 10.75 3558 723684 269046 62492734
Galactorrhoea 29.17 10.75 6 727236 4149 62757631
Anterior spinal artery syndrome 29.00 10.75 18 727224 107 62761673
Gestational diabetes 28.96 10.75 32 727210 8364 62753416
Multiple allergies 28.96 10.75 263 726979 13539 62748241
Device issue 28.90 10.75 157 727085 23624 62738156
Exposure via ingestion 28.86 10.75 86 727156 2823 62758957
Tardive dyskinesia 28.68 10.75 33 727209 8469 62753311
Labelled drug-drug interaction medication error 28.53 10.75 70 727172 13329 62748451
Blood iron abnormal 28.48 10.75 5 727237 3871 62757909
Neuropathy peripheral 28.38 10.75 1040 726202 112627 62649153
Injection site induration 27.81 10.75 39 727203 9187 62752593
Schizoaffective disorder 27.81 10.75 97 727145 3465 62758315
Hypothyroidism 27.48 10.75 334 726908 42298 62719482
Pyrexia 27.35 10.75 5939 721303 464539 62297241
Sexual dysfunction 27.28 10.75 8 727234 4351 62757429
Anaphylactic reaction 27.24 10.75 969 726273 65131 62696649
Skin toxicity 27.14 10.75 10 727232 4704 62757076
Blood pH decreased 27.12 10.75 78 727164 2509 62759271
Acute myeloid leukaemia 26.93 10.75 103 727139 17044 62744736
Culture urine positive 26.73 10.75 98 727144 3589 62758191
Bronchopulmonary aspergillosis 26.53 10.75 36 727206 8599 62753181
Hallucination, auditory 26.52 10.75 68 727174 12756 62749024
Hepatic cirrhosis 26.50 10.75 170 727072 24564 62737216
Administration site swelling 26.48 10.75 51 727191 1256 62760524
Colorectal cancer 26.14 10.75 5 727237 3640 62758140
Administration site pain 26.12 10.75 40 727202 814 62760966
Rheumatoid lung 26.11 10.75 6 727236 3842 62757938
Injury 25.94 10.75 1056 726186 72191 62689589
Pneumonia aspiration 25.67 10.75 262 726980 34278 62727502
Drug use disorder 25.50 10.75 119 727123 4865 62756915
Disorientation 25.46 10.75 309 726933 39143 62722637
Torsade de pointes 25.22 10.75 74 727168 13277 62748503
Paraesthesia 24.99 10.75 1507 725735 155459 62606321
Skin ulcer 24.88 10.75 345 726897 42700 62719080
Infusion site rash 24.78 10.75 64 727178 1930 62759850
Neutrophil percentage increased 24.60 10.75 82 727160 2861 62758919
Injection site urticaria 24.46 10.75 81 727161 13992 62747788
Infusion site mass 24.30 10.75 65 727177 2003 62759777
Cardiotoxicity 24.13 10.75 37 727205 8401 62753379
Dyskinesia 24.09 10.75 242 727000 31760 62730020
Bacterial test 24.02 10.75 46 727196 1128 62760652
Poisoning 23.82 10.75 251 726991 13449 62748331
Upper respiratory tract infection 23.81 10.75 1159 726083 80888 62680892
Product monitoring error 23.70 10.75 11 727231 4505 62757275
Seasonal allergy 23.61 10.75 354 726888 20596 62741184
Hepatic function abnormal 23.55 10.75 292 726950 36850 62724930
Condition aggravated 23.41 10.75 4152 723090 398065 62363715
Brain death 23.36 10.75 89 727153 3321 62758459
Cerebral haemorrhage 23.29 10.75 232 727010 30497 62731283
Dehydration 23.26 10.75 1690 725552 171664 62590116
Hypertensive crisis 23.26 10.75 93 727149 15193 62746587
Drug dose omission by device 23.25 10.75 13 727229 4788 62756992
Anticipatory anxiety 23.16 10.75 47 727195 1204 62760576
Hypocoagulable state 23.12 10.75 46 727196 1161 62760619
Rash pruritic 23.11 10.75 515 726727 59284 62702496
Specific gravity urine decreased 23.04 10.75 36 727206 746 62761034
Haemoglobin urine present 23.02 10.75 37 727205 786 62760994
Ear infection 22.99 10.75 587 726655 37626 62724154
Anion gap increased 22.98 10.75 60 727182 1822 62759958
Urine ketone body present 22.97 10.75 72 727170 2431 62759349
Infusion site nodule 22.95 10.75 52 727190 1440 62760340
Swollen joint count increased 22.93 10.75 558 726684 35496 62726284
Reversible airways obstruction 22.77 10.75 59 727183 1783 62759997
Aspergillus infection 22.65 10.75 36 727206 8057 62753723
Electrocardiogram QT prolonged 22.35 10.75 515 726727 59015 62702765
Metastases to lymph nodes 22.17 10.75 37 727205 8121 62753659
Fatigue 22.10 10.75 10845 716397 877183 61884597
Graft versus host disease 22.01 10.75 27 727215 6736 62755044
Intervertebral discitis 21.90 10.75 84 727158 3144 62758636
Dizziness 21.71 10.75 4471 722771 425454 62336326
Peritonitis 21.54 10.75 112 727130 17042 62744738
Vein collapse 21.48 10.75 41 727201 1003 62760777
Epstein-Barr virus infection 21.43 10.75 37 727205 8013 62753767
Blood magnesium increased 21.40 10.75 80 727162 2958 62758822
Acute myocardial infarction 21.34 10.75 250 726992 31874 62729906
Human herpesvirus 6 infection 21.33 10.75 4 727238 2953 62758827
Musculoskeletal disorder 21.05 10.75 144 727098 20500 62741280
Prothrombin time prolonged 20.97 10.75 184 727058 9380 62752400
Peptic ulcer haemorrhage 20.82 10.75 41 727201 1027 62760753
Varicella zoster virus infection 20.82 10.75 3 727239 2686 62759094
Graft versus host disease in skin 20.80 10.75 4 727238 2901 62758879
Rhythm idioventricular 20.68 10.75 20 727222 246 62761534
Analgesic drug level above therapeutic 20.68 10.75 17 727225 166 62761614
Right ventricular failure 20.60 10.75 114 727128 17074 62744706
Personality change 20.50 10.75 30 727212 6943 62754837
Anaesthetic complication 20.46 10.75 59 727183 1901 62759879
Femoral neck fracture 20.20 10.75 42 727200 8481 62753299
Coeliac disease 20.20 10.75 230 727012 12567 62749213
Hand deformity 20.14 10.75 2104 725138 157353 62604427
Methaemoglobinaemia 20.13 10.75 67 727175 2336 62759444
Haematuria 20.12 10.75 225 727017 28932 62732848
Cytomegalovirus viraemia 20.08 10.75 21 727221 5628 62756152
Dysarthria 20.07 10.75 356 726886 42355 62719425
Wound 20.03 10.75 2150 725092 161113 62600667
Acute graft versus host disease 20.02 10.75 13 727229 4415 62757365
Jaundice cholestatic 19.91 10.75 148 727094 7176 62754604
Dystonia 19.83 10.75 86 727156 13733 62748047
Sensitisation 19.80 10.75 7 727235 3379 62758401
SARS-CoV-2 test positive 19.79 10.75 159 727083 7897 62753883
Insurance issue 19.77 10.75 129 727113 5992 62755788
Breast cancer 19.76 10.75 413 726829 47970 62713810
Anosognosia 19.76 10.75 6 727236 3190 62758590
Infusion site discomfort 19.64 10.75 48 727194 1398 62760382
Drug reaction with eosinophilia and systemic symptoms 19.62 10.75 271 726971 33565 62728215
Mania 19.61 10.75 74 727168 12293 62749487
Infusion site urticaria 19.61 10.75 51 727191 1545 62760235
Injection site haematoma 19.50 10.75 30 727212 6802 62754978
Product tampering 19.48 10.75 24 727218 394 62761386
Cardiac failure acute 19.31 10.75 51 727191 9472 62752308
Ovarian hyperstimulation syndrome 19.25 10.75 11 727231 4003 62757777
Enthesopathy 19.14 10.75 44 727198 8570 62753210
Chronic graft versus host disease 18.86 10.75 6 727236 3096 62758684
Pneumocephalus 18.85 10.75 16 727226 164 62761616
Fall 18.75 10.75 4091 723151 388243 62373537
Depression 18.74 10.75 1967 725275 194525 62567255
Abnormal dreams 18.64 10.75 60 727182 10456 62751324
Neurotoxicity 18.60 10.75 116 727126 16874 62744906
Cytokine release syndrome 18.59 10.75 248 726994 14066 62747714
Pleural fibrosis 18.58 10.75 84 727158 3388 62758392
Infusion site irritation 18.49 10.75 36 727206 894 62760886
Systemic toxicity 18.49 10.75 12 727230 78 62761702
Mucormycosis 18.47 10.75 5 727237 2866 62758914
Abortion induced 18.46 10.75 58 727184 10184 62751596
Brain oedema 18.46 10.75 246 726996 13949 62747831
Peripheral sensory neuropathy 18.27 10.75 36 727206 7415 62754365
Presbyacusis 18.18 10.75 73 727169 2792 62758988
Lymphopenia 18.12 10.75 129 727113 18198 62743582
Loss of consciousness 18.10 10.75 1138 726104 116983 62644797
Bone pain 17.99 10.75 482 726760 54159 62707621
Atypical femur fracture 17.96 10.75 21 727221 5351 62756429
Brain stem glioma 17.95 10.75 16 727226 176 62761604
Ischaemic stroke 17.94 10.75 126 727116 17831 62743949
Lupus vasculitis 17.89 10.75 27 727215 542 62761238
Multiple drug therapy 17.89 10.75 86 727156 3560 62758220
Coronary artery disease 17.83 10.75 262 726980 32115 62729665
Hypomania 17.83 10.75 129 727113 6201 62755579
Mobility decreased 17.69 10.75 1615 725627 119544 62642236
Atelectasis 17.66 10.75 345 726897 21138 62740642
Corneal oedema 17.62 10.75 47 727195 1446 62760334
Administration site bruise 17.54 10.75 23 727219 403 62761377
Scoliosis 17.42 10.75 152 727090 7736 62754044
White blood cell count decreased 17.40 10.75 1364 725878 137740 62624040
Immunosuppressant drug level increased 17.40 10.75 10 727232 3628 62758152
Coagulation factor VII level decreased 17.34 10.75 12 727230 88 62761692
Concussion 17.33 10.75 172 727070 9072 62752708
Sinus operation 17.31 10.75 67 727175 2519 62759261
Treatment noncompliance 17.26 10.75 312 726930 37013 62724767
Bacterial test positive 17.23 10.75 112 727130 5195 62756585
Nausea 17.19 10.75 9217 718025 845254 61916526
Electrolyte imbalance 17.19 10.75 147 727095 19929 62741851
Pleural thickening 17.15 10.75 72 727170 2811 62758969
Eosinophil percentage increased 17.11 10.75 37 727205 992 62760788
Prothrombin time shortened 17.05 10.75 56 727186 1939 62759841
Small for dates baby 16.98 10.75 11 727231 3740 62758040
Migraine 16.87 10.75 1389 725853 101957 62659823
Congestive cardiomyopathy 16.83 10.75 28 727214 6154 62755626
Vaginal haemorrhage 16.72 10.75 218 727024 27269 62734511
Drug tolerance 16.68 10.75 34 727208 6915 62754865
Cardiovascular disorder 16.65 10.75 74 727168 11738 62750042
Oesophageal carcinoma 16.61 10.75 4 727238 2480 62759300
Coma 16.59 10.75 899 726343 63465 62698315
Lupus-like syndrome 16.45 10.75 105 727137 15190 62746590
Nerve block 16.44 10.75 31 727211 751 62761029
Coagulation factor X level decreased 16.41 10.75 11 727231 76 62761704
Transient ischaemic attack 16.39 10.75 319 726923 37434 62724346
Orthostatic hypotension 16.38 10.75 536 726706 35624 62726156
Erysipelas 16.29 10.75 42 727200 7863 62753917
Superinfection 16.21 10.75 66 727176 2541 62759239
Blood creatinine decreased 16.20 10.75 114 727128 5431 62756349
Pain 16.20 10.75 9010 718232 731618 62030162
Disturbance in attention 16.19 10.75 324 726918 37865 62723915
Cytopenia 16.16 10.75 73 727169 11528 62750252
Abnormal behaviour 16.14 10.75 162 727080 21264 62740516
Pancreatic carcinoma 16.12 10.75 40 727202 7588 62754192
Hypersensitivity vasculitis 16.12 10.75 14 727228 4098 62757682
Therapy non-responder 16.03 10.75 708 726534 75193 62686587
Injection site discolouration 15.94 10.75 42 727200 7806 62753974
Ketoacidosis 15.87 10.75 16 727226 4362 62757418
Bacterial disease carrier 15.81 10.75 42 727200 1289 62760491
Acute graft versus host disease in skin 15.79 10.75 10 727232 3442 62758338
Cardiac arrest 15.78 10.75 1248 725994 91297 62670483
Osmolar gap 15.74 10.75 12 727230 104 62761676
Epigastric discomfort 15.68 10.75 132 727110 6648 62755132
Hyperprolactinaemia 15.63 10.75 13 727229 3887 62757893
Nephropathy toxic 15.50 10.75 56 727186 9423 62752357
Maternal exposure during pregnancy 15.48 10.75 2247 724995 217815 62543965
Ventilation perfusion mismatch 15.47 10.75 24 727218 494 62761286
Pulmonary hypertension 15.42 10.75 316 726926 36807 62724973
Soft tissue disorder 15.40 10.75 95 727147 4327 62757453
Sepsis 15.40 10.75 1527 725715 151596 62610184
Anaesthetic complication neurological 15.38 10.75 17 727225 247 62761533
Blood immunoglobulin E increased 15.21 10.75 13 727229 3836 62757944
Aphasia 15.21 10.75 276 726966 32724 62729056
Atrial fibrillation 15.17 10.75 1140 726102 115496 62646284
Metastases to central nervous system 15.12 10.75 88 727154 13017 62748763
Haematemesis 15.09 10.75 251 726991 30161 62731619
Pharyngeal paraesthesia 15.07 10.75 54 727188 1955 62759825
Nephrogenic systemic fibrosis 15.03 10.75 18 727224 4538 62757242
Leukoencephalopathy 15.02 10.75 17 727225 4396 62757384
Epistaxis 15.02 10.75 680 726562 72045 62689735
Pregnancy with contraceptive device 15.00 10.75 19 727223 4675 62757105
Blood glucose increased 14.98 10.75 795 726447 82961 62678819
Lymphoproliferative disorder 14.93 10.75 9 727233 3181 62758599
Hyperammonaemia 14.91 10.75 23 727219 5209 62756571
Hypoglycaemia 14.89 10.75 550 726692 59515 62702265
Pulmonary arterial hypertension 14.88 10.75 176 727066 22401 62739379
Granuloma 14.86 10.75 27 727215 5734 62756046
Visual acuity reduced 14.83 10.75 169 727073 21657 62740123
Malaise 14.73 10.75 4396 722846 411558 62350222
Proteinuria 14.73 10.75 144 727098 19001 62742779
Irritability 14.63 10.75 265 726977 31429 62730351
Immunodeficiency 14.59 10.75 319 726923 19935 62741845
Occupational exposure to product 14.59 10.75 3 727239 2075 62759705
Aplasia pure red cell 14.51 10.75 18 727224 4469 62757311
Injection site mass 14.49 10.75 140 727102 18516 62743264
Polycystic ovaries 14.39 10.75 18 727224 4453 62757327
JC virus infection 14.32 10.75 3 727239 2048 62759732
Specific gravity urine increased 14.28 10.75 15 727227 205 62761575
COVID-19 immunisation 14.24 10.75 49 727193 1738 62760042
C-reactive protein increased 14.24 10.75 914 726328 93793 62667987
Haemorrhage 14.19 10.75 563 726679 60459 62701321
Unintended pregnancy 14.19 10.75 31 727211 6148 62755632
Bone erosion 14.17 10.75 132 727110 17585 62744195
Foetal growth restriction 14.17 10.75 42 727200 7511 62754269
Cryopyrin associated periodic syndrome 14.15 10.75 19 727223 341 62761439
Blood cholesterol increased 14.12 10.75 1256 725986 92776 62669004
Dermatitis bullous 14.09 10.75 50 727192 8458 62753322
Neuralgia 14.09 10.75 393 726849 25533 62736247
Tendonitis 14.08 10.75 150 727092 19465 62742315
Fear of injection 14.05 10.75 39 727203 7125 62754655
Graft versus host disease in gastrointestinal tract 14.01 10.75 10 727232 3231 62758549
Clostridium test positive 13.94 10.75 73 727169 3128 62758652
PO2 increased 13.93 10.75 31 727211 848 62760932
Eyelid rash 13.89 10.75 13 727229 153 62761627
Pancreatitis acute 13.88 10.75 223 727019 26943 62734837
Joint destruction 13.84 10.75 32 727210 6220 62755560
Metabolic disorder 13.82 10.75 34 727208 6469 62755311
Patent ductus arteriosus 13.80 10.75 17 727225 4233 62757547
Complication associated with device 13.79 10.75 126 727116 16852 62744928
Cytomegalovirus infection reactivation 13.79 10.75 15 727227 3948 62757832
Hepatocellular carcinoma 13.78 10.75 4 727238 2190 62759590
Foot operation 13.71 10.75 40 727202 7191 62754589
Pulmonary tuberculosis 13.71 10.75 19 727223 4498 62757282
Melaena 13.67 10.75 255 726987 30110 62731670
Stoma site cellulitis 13.67 10.75 8 727234 42 62761738
Ductus arteriosus premature closure 13.62 10.75 18 727224 318 62761462
Renal disorder 13.60 10.75 281 726961 32693 62729087
Immune reconstitution inflammatory syndrome 13.58 10.75 31 727211 6053 62755727
Caesarean section 13.58 10.75 127 727115 16905 62744875
Diffuse large B-cell lymphoma 13.57 10.75 36 727206 6676 62755104
Catatonia 13.42 10.75 19 727223 4458 62757322
Extrapyramidal disorder 13.38 10.75 93 727149 13191 62748589
Gastroenteritis 13.35 10.75 219 727023 26371 62735409
Throat tightness 13.17 10.75 376 726866 24511 62737269
Spinal meningioma benign 13.17 10.75 11 727231 110 62761670
Blood methaemoglobin present 13.11 10.75 9 727233 65 62761715
Hepatitis acute 13.11 10.75 161 727081 8959 62752821
Disease recurrence 13.05 10.75 234 727008 27796 62733984
Hallucinations, mixed 13.03 10.75 22 727220 4807 62756973
Myopathy 12.99 10.75 75 727167 11116 62750664
Product quality issue 12.98 10.75 312 726930 35553 62726227
Blood immunoglobulin A increased 12.97 10.75 28 727214 750 62761030
Non-pitting oedema 12.96 10.75 8 727234 47 62761733
Kidney transplant rejection 12.93 10.75 18 727224 4253 62757527
Polyarthritis 12.88 10.75 66 727176 10080 62751700
Hepatic encephalopathy 12.85 10.75 191 727051 11091 62750689
Product residue present 12.83 10.75 16 727226 3963 62757817
Coagulation factor decreased 12.81 10.75 10 727232 90 62761690
Nephrotic syndrome 12.78 10.75 28 727214 5548 62756232
Breast cancer stage II 12.76 10.75 54 727188 8682 62753098
Sedation 12.72 10.75 555 726687 38254 62723526
Post cholecystectomy syndrome 12.64 10.75 20 727222 419 62761361
Hepatitis B 12.64 10.75 15 727227 3797 62757983
Cestode infection 12.61 10.75 16 727226 271 62761509
Procedural hypotension 12.59 10.75 36 727206 1154 62760626
Chronic kidney disease 12.57 10.75 410 726832 44988 62716792
White coat hypertension 12.55 10.75 26 727216 676 62761104
Potentiating drug interaction 12.55 10.75 19 727223 4337 62757443
Device breakage 12.53 10.75 79 727163 11463 62750317
Abnormal loss of weight 12.47 10.75 30 727212 5752 62756028
Neovascularisation 12.47 10.75 35 727207 1110 62760670
Renal failure neonatal 12.47 10.75 13 727229 176 62761604
Dyspnoea exertional 12.42 10.75 564 726678 59738 62702042
Lip pruritus 12.40 10.75 31 727211 916 62760864
Skin infection 12.36 10.75 241 727001 14761 62747019
Schizophrenia 12.34 10.75 171 727071 9781 62751999
Adulterated product 12.32 10.75 15 727227 243 62761537
Polyomavirus-associated nephropathy 12.31 10.75 3 727239 1845 62759935
Gastritis 12.30 10.75 329 726913 36974 62724806
Nasal congestion 12.28 10.75 892 726350 64768 62697012
Balance disorder 12.27 10.75 1125 726117 83297 62678483
Infusion site haematoma 12.26 10.75 16 727226 279 62761501
Exposure to SARS-CoV-2 12.24 10.75 46 727196 1705 62760075
Infusion site discolouration 12.23 10.75 29 727213 828 62760952
Tongue disorder 12.23 10.75 71 727171 10509 62751271
Device leakage 12.23 10.75 41 727201 7055 62754725
Intermenstrual bleeding 12.20 10.75 48 727194 7878 62753902
Forced expiratory volume decreased 12.19 10.75 24 727218 4944 62756836
Low density lipoprotein increased 12.18 10.75 35 727207 6322 62755458
Prothrombin time ratio decreased 12.16 10.75 22 727220 516 62761264
Rheumatoid factor positive 12.15 10.75 1124 726118 83282 62678498
Neutrophil count decreased 12.15 10.75 525 726717 55881 62705899
Invasive ductal breast carcinoma 12.13 10.75 40 727202 6918 62754862
Pleural effusion 12.12 10.75 911 726331 92299 62669481
Toxicologic test abnormal 12.08 10.75 26 727216 695 62761085
Psychomotor skills impaired 12.07 10.75 6 727236 2362 62759418
Nitrite urine present 12.02 10.75 33 727209 1033 62760747
Full blood count abnormal 12.01 10.75 274 726968 31443 62730337
Renal ischaemia 11.98 10.75 24 727218 609 62761171
Pancreatitis 11.98 10.75 450 726792 48605 62713175
Incision site swelling 11.97 10.75 14 727228 217 62761563
Antipsychotic drug level increased 11.95 10.75 13 727229 3422 62758358
Nerve root injury 11.92 10.75 7 727235 37 62761743
Foot deformity 11.90 10.75 236 727006 27617 62734163
Adenovirus infection 11.89 10.75 14 727228 3557 62758223
Cystitis 11.87 10.75 756 726486 54235 62707545
Cystitis haemorrhagic 11.87 10.75 18 727224 4105 62757675
Chronic sinusitis 11.86 10.75 210 727032 12633 62749147
Intestinal haemorrhage 11.86 10.75 16 727226 3831 62757949
Small fibre neuropathy 11.85 10.75 20 727222 443 62761337
Treatment failure 11.83 10.75 2052 725190 196991 62564789
Amenorrhoea 11.75 10.75 66 727176 9848 62751932
Device related thrombosis 11.75 10.75 46 727196 1739 62760041
Nocardiosis 11.70 10.75 4 727238 1972 62759808
Kidney infection 11.68 10.75 348 726894 22828 62738952
Withdrawal syndrome 11.65 10.75 160 727082 19837 62741943
Arrhythmia 11.64 10.75 340 726902 37800 62723980
Arthrodesis 11.64 10.75 9 727233 2792 62758988
Haemorrhage intracranial 11.60 10.75 98 727144 13321 62748459
Bradyphrenia 11.57 10.75 41 727201 6939 62754841
Pulmonary embolism 11.54 10.75 1165 726077 115519 62646261
Atonic urinary bladder 11.53 10.75 9 727233 81 62761699
Renal papillary necrosis 11.52 10.75 15 727227 261 62761519
Stress 11.48 10.75 906 726336 66261 62695519
Spinal cord injury 11.45 10.75 29 727213 864 62760916
Monocyte percentage increased 11.45 10.75 34 727208 1114 62760666
Gastric cancer 11.43 10.75 23 727219 4700 62757080
Drug level below therapeutic 11.39 10.75 95 727147 4771 62757009
Blood prolactin increased 11.39 10.75 14 727228 3489 62758291
Focal dyscognitive seizures 11.38 10.75 10 727232 2911 62758869
Band neutrophil count increased 11.38 10.75 18 727224 377 62761403
Constipation 11.37 10.75 2822 724420 222121 62539659
Post procedural pulmonary embolism 11.35 10.75 15 727227 265 62761515
Substance abuse 11.34 10.75 94 727148 4713 62757067
Venoocclusive liver disease 11.31 10.75 24 727218 4811 62756969
Product use in unapproved indication 11.31 10.75 1840 725402 177240 62584540
Device related infection 11.30 10.75 194 727048 23198 62738582
Infusion site warmth 11.28 10.75 46 727196 1772 62760008
Vitamin K deficiency 11.25 10.75 19 727223 421 62761359
Acidosis 11.21 10.75 186 727056 11047 62750733
Liver transplant 11.21 10.75 54 727188 2237 62759543
Sinus node dysfunction 11.18 10.75 23 727219 4662 62757118
Concomitant disease aggravated 11.16 10.75 60 727182 9052 62752728
Feeling abnormal 11.16 10.75 1509 725733 146883 62614897
pH urine increased 11.14 10.75 18 727224 384 62761396
Shock haemorrhagic 11.12 10.75 67 727175 9828 62751952
Renal cancer 11.12 10.75 30 727212 5532 62756248
Hernia 11.04 10.75 204 727038 12370 62749410
Haematoma 10.99 10.75 309 726933 34511 62727269
Epstein-Barr virus associated lymphoproliferative disorder 10.93 10.75 4 727238 1890 62759890
Migraine with aura 10.92 10.75 61 727181 2679 62759101
Hypertriglyceridaemia 10.90 10.75 36 727206 6223 62755557
Spinal epidural haematoma 10.88 10.75 33 727209 1094 62760686
Purtscher retinopathy 10.86 10.75 9 727233 89 62761691
Drug level increased 10.82 10.75 339 726903 22397 62739383
Pustular psoriasis 10.79 10.75 23 727219 4603 62757177
BK virus infection 10.77 10.75 13 727229 3266 62758514
Pharyngitis streptococcal 10.76 10.75 177 727065 10495 62751285

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 680.62 10.95 3439 294597 196923 34461972
Infusion related reaction 644.62 10.95 1408 296628 51649 34607246
Completed suicide 571.03 10.95 1988 296048 96180 34562715
Exposure to toxic agent 402.43 10.95 297 297739 3378 34655517
Blood pressure fluctuation 366.21 10.95 721 297315 24528 34634367
Heart rate decreased 242.83 10.95 707 297329 31038 34627857
Overdose 241.80 10.95 1464 296572 89595 34569300
Blood pressure increased 217.33 10.95 1390 296646 86712 34572183
Acute hepatic failure 215.14 10.95 411 297625 13663 34645232
Drug interaction 176.96 10.95 1164 296872 224782 34434113
Intentional overdose 175.37 10.95 788 297248 42886 34616009
Intentional product misuse 169.88 10.95 805 297231 44806 34614089
Chills 141.28 10.95 1177 296859 79866 34579029
Blood pressure diastolic abnormal 137.54 10.95 187 297849 4631 34654264
Drug resistance 135.26 10.95 28 298008 25899 34632996
Oxygen saturation decreased 128.85 10.95 843 297193 52975 34605920
Methaemoglobinaemia 122.54 10.95 152 297884 3429 34655466
Sinusitis 119.02 10.95 680 297356 40722 34618173
Blood pressure systolic increased 118.04 10.95 447 297589 22505 34636390
Cardiac failure 116.16 10.95 394 297642 90854 34568041
Drug ineffective 114.78 10.95 2993 295043 453758 34205137
Blood pressure systolic abnormal 100.44 10.95 145 297891 3803 34655092
Myocardial infarction 93.48 10.95 626 297410 120459 34538436
Cytokine release syndrome 93.47 10.95 415 297621 22462 34636433
Hepatic cytolysis 93.26 10.95 304 297732 14192 34644703
Intentional product use issue 86.37 10.95 834 297202 58982 34599913
Anaphylactic reaction 82.24 10.95 514 297522 31787 34627108
Anaemia 80.34 10.95 1453 296583 231882 34427013
Anion gap 79.39 10.95 63 297973 804 34658091
Analgesic drug level increased 77.95 10.95 62 297974 794 34658101
Blood pressure diastolic increased 75.87 10.95 146 297890 4879 34654016
Infusion site extravasation 75.37 10.95 134 297902 4210 34654685
COVID-19 74.28 10.95 998 297038 76552 34582343
Metabolic acidosis 73.20 10.95 629 297407 43051 34615844
Interstitial lung disease 72.53 10.95 298 297738 64984 34593911
Coagulopathy 69.84 10.95 344 297692 19445 34639450
Body temperature decreased 69.63 10.95 257 297779 12777 34646118
Renal impairment 69.27 10.95 496 297540 94017 34564878
Myelosuppression 69.20 10.95 39 297997 19226 34639669
Bone marrow failure 68.74 10.95 89 297947 29164 34629731
Accidental overdose 66.78 10.95 344 297692 19796 34639099
Treatment failure 66.18 10.95 192 297844 46505 34612390
Hypotension 64.58 10.95 2403 295633 219246 34439649
Cardiac failure congestive 64.47 10.95 430 297606 82840 34576055
Heart rate increased 62.44 10.95 637 297399 45706 34613189
Back pain 61.22 10.95 1414 296622 120375 34538520
Local anaesthetic systemic toxicity 60.66 10.95 36 298000 274 34658621
General physical health deterioration 57.21 10.95 760 297276 127509 34531386
Pyroglutamic acidosis 57.21 10.95 39 297997 387 34658508
Diarrhoea 56.61 10.95 2733 295303 387179 34271716
Anaesthetic complication 56.19 10.95 58 297978 1062 34657833
Sopor 55.78 10.95 17 298019 12119 34646776
Infusion site swelling 54.67 10.95 86 297950 2438 34656457
Flushing 53.34 10.95 465 297571 31955 34626940
Urticaria 51.43 10.95 782 297254 61595 34597300
Foetal exposure during pregnancy 50.18 10.95 162 297874 37939 34620956
Infusion site pain 49.91 10.95 105 297931 3746 34655149
Body temperature increased 49.72 10.95 285 297751 17083 34641812
Respiratory depression 49.44 10.95 271 297765 15974 34642921
Therapeutic product effect incomplete 49.34 10.95 242 297794 50299 34608596
Heart rate irregular 48.98 10.95 265 297771 15542 34643353
Medication error 48.67 10.95 379 297657 25186 34633709
Labelled drug-drug interaction medication error 48.48 10.95 34 298002 14905 34643990
Throat irritation 47.84 10.95 198 297838 10387 34648508
Cerebral infarction 47.38 10.95 102 297934 27353 34631542
Respiratory arrest 46.54 10.95 403 297633 27640 34631255
Pancytopenia 45.31 10.95 556 297480 94601 34564294
Prostate cancer 45.28 10.95 179 297857 39470 34619425
Haematotoxicity 44.53 10.95 8 298028 8186 34650709
Bladder cancer 44.25 10.95 44 297992 16234 34642661
Hepatotoxicity 43.99 10.95 324 297712 21161 34637734
Toxic anterior segment syndrome 43.87 10.95 52 297984 1117 34657778
Infusion site pruritus 43.80 10.95 44 297992 779 34658116
Malignant neoplasm progression 43.24 10.95 511 297525 87535 34571360
Poor venous access 43.09 10.95 119 297917 5064 34653831
Cytomegalovirus infection 42.73 10.95 100 297936 26035 34632860
Diabetes mellitus 42.06 10.95 231 297805 46642 34612253
Coronary artery disease 41.75 10.95 241 297795 48064 34610831
Ear infection 41.33 10.95 185 297851 10046 34648849
Pain 41.11 10.95 2136 295900 202539 34456356
Immune reconstitution inflammatory syndrome 40.75 10.95 12 298024 8747 34650148
Product prescribing error 40.55 10.95 84 297952 22843 34636052
Throat tightness 39.88 10.95 159 297877 8199 34650696
Leukopenia 39.46 10.95 344 297692 62512 34596383
Blood pressure diastolic decreased 39.45 10.95 168 297868 8926 34649969
Hyperkalaemia 39.16 10.95 390 297646 68999 34589896
Cerebral haemorrhage 39.09 10.95 159 297877 34778 34624117
Acute kidney injury 38.61 10.95 2167 295869 302821 34356074
Inappropriate schedule of product administration 37.96 10.95 744 297292 61552 34597343
Nasopharyngitis 37.84 10.95 821 297215 69147 34589748
Wrong technique in product usage process 37.06 10.95 169 297867 35817 34623078
Progressive multifocal leukoencephalopathy 36.18 10.95 19 298017 9745 34649150
Renal cortical necrosis 35.77 10.95 23 298013 205 34658690
Hypoxia 34.93 10.95 662 297374 54433 34604462
Oesophageal carcinoma 34.63 10.95 18 298018 9286 34649609
Disease progression 34.62 10.95 681 297355 107396 34551499
Multiple-drug resistance 33.57 10.95 3 298033 5236 34653659
Pharyngeal paraesthesia 33.51 10.95 35 298001 650 34658245
Respiratory rate increased 33.50 10.95 170 297866 9724 34649171