phencyclidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
muscarinic receptors agonists/antagonists 2121 77-10-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phencyclidine hydrochloride
  • phencyclidine
  • phencyclidine HCl
  • phencyclidine hydrobromide
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
  • Molecular weight: 243.39
  • Formula: C17H25N
  • CLOGP: 5.10
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.87
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 72 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.35 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 16 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D006213 Hallucinogens
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:35471 psychopharmaceuticals
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:60643 n-methyl-d-aspartate receptor antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lysosomal Pro-X carboxypeptidase Enzyme IC50 7.04 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.96 CHEMBL
Glutamate NMDA receptor; GRIN1/GRIN2B Ion channel IC50 5.90 CHEMBL
Glutamate NMDA receptor; GRIN1/GRIN2A Ion channel IC50 6.40 CHEMBL
Glutamate [NMDA] receptor Ion channel Ki 7.82 CHEMBL
Glutamate receptor ionotropic, NMDA 1 Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Kd 5.04 CHEMBL
Glutamate receptor ionotropic, NMDA 2C Ion channel Ki 7.22 CHEMBL
Cholinesterase Enzyme Ki 6.28 CHEMBL
Glutamate NMDA receptor Ion channel Ki 7.42 CHEMBL
Acetylcholine receptor subunit alpha Ion channel IC50 6.66 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.28 CHEMBL

External reference:

IDSource
D05453 KEGG_DRUG
956-90-1 SECONDARY_CAS_RN
4027426 VANDF
C0031381 UMLSCUI
CHEBI:8058 CHEBI
1PC PDB_CHEM_ID
CHEMBL275528 ChEMBL_ID
CHEMBL542581 ChEMBL_ID
D010622 MESH_DESCRIPTOR_UI
DB03575 DRUGBANK_ID
4282 IUPHAR_LIGAND_ID
1058 INN_ID
J1DOI7UV76 UNII
6468 PUBCHEM_CID
d03880 MMSL
9721008 SNOMEDCT_US

Pharmaceutical products:

None