phenazocine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
narcotic antagonists/agonists related to 6,7-benzomorphan	2119	127-35-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenazocine
phenethylazocine
phenobenzorphan
phenazocine hydrobromide
fenazocine

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)

Molecular weight: 321.46
Formula: C22H27NO
CLOGP: 4.91
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 23.47
ALOGS: -4.64
ROTB: 3

Drug dosage:

Dose	Unit	Route
3	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02AD02	NERVOUS SYSTEM ANALGESICS OPIOIDS Benzomorphan derivatives
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009294	Narcotics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.26	acidic
pKa2	9.16	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	9.70		CHEMBL
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN		Ki	8.70		CHEMBL
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		Ki	8.30		CHEMBL
Mu-type opioid receptor	GPCR		OPRM_MOUSE		IC50	8.10		CHEMBL
Mu-type opioid receptor	GPCR		OPRM_CAVPO		IC50	8.01		CHEMBL

External reference:

ID	Source
N0000166903	NUI
1239-04-9	SECONDARY_CAS_RN
C0031376	UMLSCUI
CHEBI:8056	CHEBI
CHEMBL46399	ChEMBL_ID
DB13606	DRUGBANK_ID
D010620	MESH_DESCRIPTOR_UI
14707	PUBCHEM_CID
900	INN_ID
J0ND6N0AQC	UNII
104979	RXNORM
001564	NDDF
004626	NDDF
322619008	SNOMEDCT_US
387326002	SNOMEDCT_US
58360000	SNOMEDCT_US
CHEMBL2107297	ChEMBL_ID
58073-76-0	SECONDARY_CAS_RN

Pharmaceutical products:

None