perlapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
psychoactive	2111	1977-11-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

perlapine
hypnodin
perlapine monohydrochloride
perlapine hydrochloride
perlapine HCl
HUF-2333

Molecular weight: 291.40
Formula: C19H21N3
CLOGP: 3.24
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 18.84
ALOGS: -3.44
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	Basic
pKa2	5.32	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.22		PDSP
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	7.70		PDSP
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.82		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7		PDSP
Histamine H4 receptor	GPCR	Q9H3N8	HRH4_HUMAN		Ki	5.32		CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	7.52		PDSP
D(2) dopamine receptor	GPCR		DRD2_RAT		IC50	5.57		CHEMBL

External reference:

ID	Source
D01438	KEGG_DRUG
C0070450	UMLSCUI
CHEBI:31983	CHEBI
CHEMBL340801	ChEMBL_ID
C003910	MESH_SUPPLEMENTAL_RECORD_UI
16106	PUBCHEM_CID
2825	INN_ID
4N8UJJ27IM	UNII

Pharmaceutical products:

None