periciazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2107 2622-26-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • periciazine
  • nelactil
  • nemactil
  • neulactil
  • periciazinum
  • pericyazine
  • properciazine
  • propericiazine
  • propericyazine
  • Molecular weight: 365.50
  • Formula: C21H23N3OS
  • CLOGP: 3.44
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 50.50
  • ALOGS: -3.79
  • ROTB: 4

Drug dosage:

DoseUnitRoute
50 mg O
20 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 16.28 0 3 10 7236 2350836

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC N05AC01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperidine structure
CHEBI has role CHEBI:37887 adrenergic antagonist
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:65190 first generation antipsychotic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.84 Basic
pKa2 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 5.15 CHEMBL
Androgen receptor Transcription factor Ki 5.52 CHEMBL
Cholinesterase Enzyme IC50 6.64 CHEMBL

External reference:

IDSource
C0033459 UMLSCUI
D01485 KEGG_DRUG
3405M6FD73 UNII
1398 INN_ID
321467007 SNOMEDCT_US
8766 RXNORM
003467 NDDF
395825007 SNOMEDCT_US
CHEMBL251940 ChEMBL_ID
DB01608 DRUGBANK_ID
CHEBI:31981 CHEBI
C084584 MESH_SUPPLEMENTAL_RECORD_UI
4747 PUBCHEM_CID
9216 IUPHAR_LIGAND_ID

Pharmaceutical products:

None