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periciazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2107 | 2622-26-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
| 20 | mg | P |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK | 47 | |||
| kinase-selectivity-class | AXL,CAMK2D,EIF2AK3,PDK4 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Resting tremor | 60.43 | 57.31 | 9 | 408 | 874 | 90627156 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Wrong patient received product | 78.72 | 47.36 | 16 | 706 | 6658 | 110581919 |
| Resting tremor | 51.23 | 47.36 | 9 | 713 | 1714 | 110586863 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AC01 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperidine structure |
| CHEBI has role | CHEBI:35717 | sedative |
| CHEBI has role | CHEBI:37887 | adrenergic antagonist |
| CHEBI has role | CHEBI:65190 | first generation antipsychotic |
Related Drugs by ATC class:
N05AC Phenothiazines with piperidine structure 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.84 | Basic |
| pKa2 | 2.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor | GPCR | ANTAGONIST | Ki | 8 | IUPHAR | ||||
| Androgen receptor | Transcription factor | Ki | 5.52 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.15 | CHEMBL | |||||
| Cholinesterase | Enzyme | IC50 | 6.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01485 | KEGG_DRUG |
| C0033459 | UMLSCUI |
| CHEBI:31981 | CHEBI |
| CHEMBL251940 | ChEMBL_ID |
| DB01608 | DRUGBANK_ID |
| C084584 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4747 | PUBCHEM_CID |
| 9216 | IUPHAR_LIGAND_ID |
| 1398 | INN_ID |
| 3405M6FD73 | UNII |
| 8766 | RXNORM |
| 003467 | NDDF |
| 321467007 | SNOMEDCT_US |
| 395825007 | SNOMEDCT_US |
| 3405M6FD73 | INXIGHT DRUGS |
Pharmaceutical products:
None