All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

penfluridol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2080	26864-56-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: penfluridol R-16341	One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS. Molecular weight: 523.97 Formula: C28H27ClF5NO CLOGP: 7.11 LIPINSKI: 2 HAC: 2 HDO: 1 TPSA: 23.47 ALOGS: -5.85 ROTB: 8

Drug dosage:

Dose	Unit	Route
6	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AG03	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diphenylbutylpiperidine derivatives
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	6		CHEMBL
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	6.06		CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	6.83		CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	6.80		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	6.45		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.44		CHEMBL
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.74		CHEMBL
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.68		PDSP
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6		CHEMBL
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.40		CHEMBL
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.87		CHEMBL
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	6.90		CHEMBL
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	6		CHEMBL
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	6		CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		Ki	6.29		CHEMBL
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN		Ki	5.45		CHEMBL
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.35		CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	6		CHEMBL
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.22		CHEMBL
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN		Ki	6		CHEMBL
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		Ki	5.77		CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		IC50	7.21		CHEMBL

External reference:

ID	Source
N0000167198	NUI
D02630	KEGG_DRUG
C0030815	UMLSCUI
CHEBI:92278	CHEBI
CHEMBL47050	ChEMBL_ID
D010395	MESH_DESCRIPTOR_UI
DB13791	DRUGBANK_ID
2919	INN_ID
25TLU22Q8H	UNII
33630	PUBCHEM_CID
7974	RXNORM
005285	NDDF
710292006	SNOMEDCT_US

Pharmaceutical products:

None