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penfluridol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2080 | 26864-56-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1 | 36 | |||
| kinase-selectivity-class | AKT3,AXL,EIF2AK3,EPHB4,PDK4 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AG03 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diphenylbutylpiperidine derivatives |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
Related Drugs by ATC class:
N05AG Diphenylbutylpiperidine derivatives 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.65 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | Ki | 6.06 | CHEMBL | |||||
| D(1A) dopamine receptor | GPCR | Ki | 6.83 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 6.80 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.45 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.44 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.74 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.68 | PDSP | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 6 | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.40 | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | Ki | 6.87 | CHEMBL | |||||
| D(1B) dopamine receptor | GPCR | Ki | 6.90 | CHEMBL | |||||
| Histamine H1 receptor | GPCR | Ki | 6 | CHEMBL | |||||
| Histamine H2 receptor | GPCR | Ki | 6 | CHEMBL | |||||
| Beta-3 adrenergic receptor | GPCR | Ki | 6.29 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.45 | CHEMBL | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 6.35 | CHEMBL | |||||
| D(4) dopamine receptor | GPCR | Ki | 6 | CHEMBL | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 6.22 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Ki | 6 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 5.77 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 5A | GPCR | Ki | 6 | CHEMBL | |||||
| Dopamine receptor | GPCR | IC50 | 7.21 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167198 | NUI |
| D02630 | KEGG_DRUG |
| C0030815 | UMLSCUI |
| CHEBI:92278 | CHEBI |
| CHEMBL47050 | ChEMBL_ID |
| D010395 | MESH_DESCRIPTOR_UI |
| DB13791 | DRUGBANK_ID |
| 2919 | INN_ID |
| 25TLU22Q8H | UNII |
| 33630 | PUBCHEM_CID |
| 7974 | RXNORM |
| 005285 | NDDF |
| 710292006 | SNOMEDCT_US |
| A1L60 | PDB_CHEM_ID |
Pharmaceutical products:
None