Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 2068 | 61869-08-7 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 5.40 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.53 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 18 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 18 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 13 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1992 | FDA | APOTEX TECHNOLOGIES |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 913.40 | 10.00 | 575 | 101725 | 25282 | 56164485 |
Atrial septal defect | 767.59 | 10.00 | 326 | 101974 | 6180 | 56183587 |
Serotonin syndrome | 649.96 | 10.00 | 470 | 101830 | 26020 | 56163747 |
Suicidal ideation | 475.35 | 10.00 | 555 | 101745 | 57187 | 56132580 |
Drug abuse | 458.08 | 10.00 | 589 | 101711 | 67021 | 56122746 |
Ventricular septal defect | 428.05 | 10.00 | 189 | 102111 | 3949 | 56185818 |
Patent ductus arteriosus | 397.58 | 10.00 | 177 | 102123 | 3774 | 56185993 |
Rheumatoid arthritis | 375.03 | 10.00 | 115 | 102185 | 382489 | 55807278 |
Sopor | 366.35 | 10.00 | 304 | 101996 | 20618 | 56169149 |
Anxiety | 365.74 | 10.00 | 967 | 101333 | 192205 | 55997562 |
Exposure during pregnancy | 346.51 | 10.00 | 765 | 101535 | 135577 | 56054190 |
Suicide attempt | 344.22 | 10.00 | 473 | 101827 | 57363 | 56132404 |
Depression | 285.97 | 10.00 | 846 | 101454 | 179271 | 56010496 |
Contraindicated product administered | 271.19 | 10.00 | 17 | 102283 | 186269 | 56003498 |
Agitation | 267.55 | 10.00 | 413 | 101887 | 55623 | 56134144 |
Tremor | 251.43 | 10.00 | 628 | 101672 | 120461 | 56069306 |
Heart disease congenital | 247.28 | 10.00 | 91 | 102209 | 1157 | 56188610 |
Alopecia | 242.73 | 10.00 | 115 | 102185 | 293343 | 55896424 |
Congenital anomaly | 242.26 | 10.00 | 96 | 102204 | 1511 | 56188256 |
Systemic lupus erythematosus | 233.34 | 10.00 | 27 | 102273 | 180051 | 56009716 |
Intentional self-injury | 232.33 | 10.00 | 256 | 102044 | 24736 | 56165031 |
Cardiac murmur | 227.82 | 10.00 | 179 | 102121 | 11222 | 56178545 |
Mydriasis | 223.78 | 10.00 | 175 | 102125 | 10896 | 56178871 |
Drug interaction | 222.86 | 10.00 | 861 | 101439 | 208894 | 55980873 |
Nightmare | 217.69 | 10.00 | 206 | 102094 | 16620 | 56173147 |
Glossodynia | 212.95 | 10.00 | 17 | 102283 | 152441 | 56037326 |
Pulmonary valve stenosis | 210.79 | 10.00 | 59 | 102241 | 280 | 56189487 |
Drug ineffective | 209.80 | 10.00 | 911 | 101389 | 918078 | 55271689 |
Joint swelling | 208.64 | 10.00 | 135 | 102165 | 289665 | 55900102 |
Multiple congenital abnormalities | 200.75 | 10.00 | 64 | 102236 | 508 | 56189259 |
Foetal exposure during pregnancy | 198.72 | 10.00 | 275 | 102025 | 33548 | 56156219 |
Drug intolerance | 198.03 | 10.00 | 118 | 102182 | 264700 | 55925067 |
Synovitis | 192.83 | 10.00 | 31 | 102269 | 161274 | 56028493 |
Off label use | 189.33 | 10.00 | 461 | 101839 | 555719 | 55634048 |
Persistent foetal circulation | 171.07 | 10.00 | 46 | 102254 | 182 | 56189585 |
Treatment failure | 168.81 | 10.00 | 50 | 102250 | 170342 | 56019425 |
Somnolence | 168.73 | 10.00 | 665 | 101635 | 162748 | 56027019 |
Irritability | 168.49 | 10.00 | 237 | 102063 | 29351 | 56160416 |
Depersonalisation/derealisation disorder | 167.30 | 10.00 | 69 | 102231 | 1210 | 56188557 |
Pericarditis | 161.30 | 10.00 | 9 | 102291 | 108914 | 56080853 |
Abdominal discomfort | 158.63 | 10.00 | 162 | 102138 | 277112 | 55912655 |
Anger | 156.93 | 10.00 | 146 | 102154 | 11526 | 56178241 |
Mania | 156.63 | 10.00 | 145 | 102155 | 11375 | 56178392 |
Hallucinations, mixed | 155.14 | 10.00 | 98 | 102202 | 4326 | 56185441 |
Pulmonary artery stenosis congenital | 153.81 | 10.00 | 43 | 102257 | 203 | 56189564 |
Hyponatraemia | 153.60 | 10.00 | 471 | 101829 | 101668 | 56088099 |
Infusion related reaction | 153.47 | 10.00 | 95 | 102205 | 208836 | 55980931 |
Swelling | 151.40 | 10.00 | 128 | 102172 | 239643 | 55950124 |
Rash | 151.39 | 10.00 | 430 | 101870 | 492617 | 55697150 |
Panic attack | 149.22 | 10.00 | 185 | 102115 | 20262 | 56169505 |
Neuroleptic malignant syndrome | 147.47 | 10.00 | 140 | 102160 | 11338 | 56178429 |
Hyperhidrosis | 145.33 | 10.00 | 438 | 101862 | 93650 | 56096117 |
Disturbance in attention | 144.41 | 10.00 | 232 | 102068 | 32308 | 56157459 |
Bradyphrenia | 143.30 | 10.00 | 109 | 102191 | 6511 | 56183256 |
Dissociation | 140.28 | 10.00 | 76 | 102224 | 2509 | 56187258 |
Disorientation | 138.45 | 10.00 | 243 | 102057 | 36370 | 56153397 |
Derealisation | 136.94 | 10.00 | 57 | 102243 | 1024 | 56188743 |
Arthropathy | 133.83 | 10.00 | 101 | 102199 | 200174 | 55989593 |
Coarctation of the aorta | 133.11 | 10.00 | 47 | 102253 | 526 | 56189241 |
Activation syndrome | 131.60 | 10.00 | 37 | 102263 | 179 | 56189588 |
Completed suicide | 131.18 | 10.00 | 536 | 101764 | 133297 | 56056470 |
Aggression | 130.86 | 10.00 | 180 | 102120 | 21826 | 56167941 |
Mood swings | 129.46 | 10.00 | 156 | 102144 | 16591 | 56173176 |
Pain | 129.46 | 10.00 | 694 | 101606 | 662490 | 55527277 |
Hypersensitivity | 126 | 10.00 | 169 | 102131 | 256239 | 55933528 |
Inappropriate antidiuretic hormone secretion | 122.82 | 10.00 | 138 | 102162 | 13618 | 56176149 |
Confusional state | 122.26 | 10.00 | 720 | 101580 | 207435 | 55982332 |
Feeling of despair | 121.59 | 10.00 | 65 | 102235 | 2088 | 56187679 |
Product use issue | 120.26 | 10.00 | 97 | 102203 | 185944 | 56003823 |
Overdose | 120.10 | 10.00 | 444 | 101856 | 105386 | 56084381 |
Restlessness | 115.85 | 10.00 | 188 | 102112 | 26398 | 56163369 |
Fallot's tetralogy | 112.58 | 10.00 | 27 | 102273 | 58 | 56189709 |
Therapeutic product effect decreased | 112.49 | 10.00 | 86 | 102214 | 169366 | 56020401 |
Withdrawal syndrome | 111.26 | 10.00 | 152 | 102148 | 18310 | 56171457 |
Hallucination, auditory | 110.48 | 10.00 | 120 | 102180 | 11404 | 56178363 |
Helicobacter infection | 108.63 | 10.00 | 6 | 102294 | 73262 | 56116505 |
Developmental delay | 108.46 | 10.00 | 52 | 102248 | 1320 | 56188447 |
Peripheral swelling | 105.18 | 10.00 | 165 | 102135 | 234561 | 55955206 |
Discomfort | 103.29 | 10.00 | 65 | 102235 | 141696 | 56048071 |
Gastric pH decreased | 103.01 | 10.00 | 41 | 102259 | 653 | 56189114 |
Dyskinesia | 102.12 | 10.00 | 187 | 102113 | 28921 | 56160846 |
Myoglobin urine present | 100.19 | 10.00 | 38 | 102262 | 528 | 56189239 |
Toxicity to various agents | 97.92 | 10.00 | 721 | 101579 | 223843 | 55965924 |
Hepatic enzyme increased | 95.81 | 10.00 | 102 | 102198 | 171282 | 56018485 |
Poisoning deliberate | 94.29 | 10.00 | 103 | 102197 | 9850 | 56179917 |
Congenital aortic stenosis | 87.55 | 10.00 | 17 | 102283 | 3 | 56189764 |
Wound | 85.23 | 10.00 | 76 | 102224 | 138728 | 56051039 |
Arthralgia | 84.37 | 10.00 | 550 | 101750 | 501119 | 55688648 |
Nasopharyngitis | 82.29 | 10.00 | 174 | 102126 | 220785 | 55968982 |
Blister | 82.00 | 10.00 | 48 | 102252 | 108839 | 56080928 |
Insomnia | 81.89 | 10.00 | 613 | 101687 | 191247 | 55998520 |
Drug dependence | 81.88 | 10.00 | 147 | 102153 | 22386 | 56167381 |
Agoraphobia | 81.77 | 10.00 | 29 | 102271 | 329 | 56189438 |
Stomatitis | 80.55 | 10.00 | 61 | 102239 | 120749 | 56069018 |
Cogwheel rigidity | 79.71 | 10.00 | 47 | 102253 | 1830 | 56187937 |
Transposition of the great vessels | 79.71 | 10.00 | 25 | 102275 | 187 | 56189580 |
Flat affect | 79.40 | 10.00 | 42 | 102258 | 1320 | 56188447 |
Tearfulness | 79.27 | 10.00 | 61 | 102239 | 3707 | 56186060 |
Rheumatoid factor positive | 78.70 | 10.00 | 15 | 102285 | 69045 | 56120722 |
Muscle rigidity | 76.97 | 10.00 | 96 | 102204 | 10575 | 56179192 |
Crying | 76.80 | 10.00 | 139 | 102161 | 21301 | 56168466 |
Lower respiratory tract infection | 76.48 | 10.00 | 58 | 102242 | 114736 | 56075031 |
Extrapyramidal disorder | 76.38 | 10.00 | 103 | 102197 | 12253 | 56177514 |
Memory impairment | 75.71 | 10.00 | 335 | 101965 | 86222 | 56103545 |
Depressed mood | 74.73 | 10.00 | 188 | 102112 | 36171 | 56153596 |
Talipes | 74.39 | 10.00 | 41 | 102259 | 1401 | 56188366 |
Delirium | 72.38 | 10.00 | 205 | 102095 | 42312 | 56147455 |
Febrile neutropenia | 72.03 | 10.00 | 52 | 102248 | 105493 | 56084274 |
Emotional disorder | 70.74 | 10.00 | 99 | 102201 | 12196 | 56177571 |
Homicidal ideation | 70.52 | 10.00 | 42 | 102258 | 1666 | 56188101 |
Folliculitis | 69.29 | 10.00 | 9 | 102291 | 54970 | 56134797 |
Hypoplastic left heart syndrome | 68.74 | 10.00 | 22 | 102278 | 177 | 56189590 |
Intentional product use issue | 68.24 | 10.00 | 49 | 102251 | 99684 | 56090083 |
Muscle injury | 67.62 | 10.00 | 8 | 102292 | 52492 | 56137275 |
Bronchial neoplasm | 67.21 | 10.00 | 27 | 102273 | 441 | 56189326 |
Cough | 66.81 | 10.00 | 245 | 102055 | 259716 | 55930051 |
H1N1 influenza | 66.70 | 10.00 | 40 | 102260 | 1607 | 56188160 |
Speech disorder developmental | 65.79 | 10.00 | 29 | 102271 | 603 | 56189164 |
Nervousness | 64.91 | 10.00 | 155 | 102145 | 28860 | 56160907 |
Dystonia | 62.69 | 10.00 | 94 | 102206 | 12327 | 56177440 |
Bronchial haemorrhage | 62.68 | 10.00 | 27 | 102273 | 530 | 56189237 |
Abnormal behaviour | 62.16 | 10.00 | 123 | 102177 | 20149 | 56169618 |
Intentional overdose | 62.12 | 10.00 | 267 | 102033 | 67850 | 56121917 |
Impulsive behaviour | 62.07 | 10.00 | 37 | 102263 | 1470 | 56188297 |
Hyperreflexia | 61.73 | 10.00 | 61 | 102239 | 5189 | 56184578 |
Altered state of consciousness | 61.55 | 10.00 | 132 | 102168 | 22889 | 56166878 |
Libido increased | 61.42 | 10.00 | 35 | 102265 | 1277 | 56188490 |
Parkinsonism | 61.19 | 10.00 | 81 | 102219 | 9465 | 56180302 |
Infection | 60.93 | 10.00 | 175 | 102125 | 200031 | 55989736 |
Congenital cardiovascular anomaly | 60.79 | 10.00 | 18 | 102282 | 108 | 56189659 |
Maternal exposure during pregnancy | 60.42 | 10.00 | 162 | 102138 | 189391 | 56000376 |
Myoclonus | 60.19 | 10.00 | 103 | 102197 | 15100 | 56174667 |
Nasal turbinate hypertrophy | 59.35 | 10.00 | 28 | 102272 | 685 | 56189082 |
Cyanosis | 58.54 | 10.00 | 104 | 102196 | 15706 | 56174061 |
Bicuspid aortic valve | 57.56 | 10.00 | 17 | 102283 | 101 | 56189666 |
Pulmonary valve stenosis congenital | 57.23 | 10.00 | 18 | 102282 | 136 | 56189631 |
Clonus | 56.82 | 10.00 | 53 | 102247 | 4196 | 56185571 |
Cleft palate | 56.36 | 10.00 | 30 | 102270 | 955 | 56188812 |
Homicide | 54.62 | 10.00 | 22 | 102278 | 362 | 56189405 |
Mobility decreased | 54.09 | 10.00 | 60 | 102240 | 98931 | 56090836 |
Drooling | 53.44 | 10.00 | 47 | 102253 | 3447 | 56186320 |
Endometrial ablation | 53.02 | 10.00 | 28 | 102272 | 877 | 56188890 |
Anomalous pulmonary venous connection | 52.97 | 10.00 | 14 | 102286 | 51 | 56189716 |
Right ventricular hypertrophy | 51.98 | 10.00 | 25 | 102275 | 639 | 56189128 |
Feeling of body temperature change | 51.52 | 10.00 | 52 | 102248 | 4537 | 56185230 |
General physical health deterioration | 51.43 | 10.00 | 149 | 102151 | 169861 | 56019906 |
Affective disorder | 51.37 | 10.00 | 57 | 102243 | 5546 | 56184221 |
Psoriatic arthropathy | 51.09 | 10.00 | 36 | 102264 | 73972 | 56115795 |
Thermal burn | 50.63 | 10.00 | 56 | 102244 | 5429 | 56184338 |
Hallucination | 50.60 | 10.00 | 200 | 102100 | 48949 | 56140818 |
Amnesia | 50.55 | 10.00 | 192 | 102108 | 46130 | 56143637 |
Hypomania | 50.43 | 10.00 | 53 | 102247 | 4849 | 56184918 |
Paraesthesia | 49.56 | 10.00 | 406 | 101894 | 130108 | 56059659 |
Feeling jittery | 49.53 | 10.00 | 83 | 102217 | 11963 | 56177804 |
Vertigo | 49.06 | 10.00 | 213 | 102087 | 54359 | 56135408 |
Renal ischaemia | 48.55 | 10.00 | 23 | 102277 | 568 | 56189199 |
Impaired healing | 48.14 | 10.00 | 52 | 102248 | 86789 | 56102978 |
Depressed level of consciousness | 47.51 | 10.00 | 216 | 102084 | 56217 | 56133550 |
Speech disorder | 47.36 | 10.00 | 163 | 102137 | 37330 | 56152437 |
Menstrual disorder | 47.13 | 10.00 | 50 | 102250 | 4625 | 56185142 |
Delusion | 47.08 | 10.00 | 78 | 102222 | 11137 | 56178630 |
Therapeutic product ineffective | 46.73 | 10.00 | 30 | 102270 | 1362 | 56188405 |
Malignant neoplasm progression | 46.72 | 10.00 | 39 | 102261 | 73548 | 56116219 |
Pneumonia | 46.61 | 10.00 | 494 | 101806 | 406604 | 55783163 |
Self esteem decreased | 45.90 | 10.00 | 22 | 102278 | 558 | 56189209 |
Abnormal dreams | 45.84 | 10.00 | 71 | 102229 | 9578 | 56180189 |
Hyperprolactinaemia | 45.78 | 10.00 | 44 | 102256 | 3617 | 56186150 |
Psychotic disorder | 45.49 | 10.00 | 119 | 102181 | 23439 | 56166328 |
Fatigue | 45.38 | 10.00 | 1090 | 101210 | 787462 | 55402305 |
Loss of libido | 44.89 | 10.00 | 28 | 102272 | 1208 | 56188559 |
Dizziness | 44.63 | 10.00 | 944 | 101356 | 375196 | 55814571 |
Dependence | 43.48 | 10.00 | 33 | 102267 | 1964 | 56187803 |
Bronchial disorder | 43.47 | 10.00 | 27 | 102273 | 1156 | 56188611 |
Parosmia | 43.32 | 10.00 | 48 | 102252 | 4663 | 56185104 |
Muscle twitching | 43.27 | 10.00 | 93 | 102207 | 16149 | 56173618 |
Depressive symptom | 43.23 | 10.00 | 42 | 102258 | 3499 | 56186268 |
Craniosynostosis | 43.21 | 10.00 | 15 | 102285 | 159 | 56189608 |
Akathisia | 42.99 | 10.00 | 65 | 102235 | 8587 | 56181180 |
Apathy | 42.74 | 10.00 | 62 | 102238 | 7892 | 56181875 |
Hip arthroplasty | 42.72 | 10.00 | 9 | 102291 | 38614 | 56151153 |
Irritable bowel syndrome | 42.58 | 10.00 | 37 | 102263 | 68421 | 56121346 |
Breath sounds abnormal | 42.40 | 10.00 | 66 | 102234 | 8941 | 56180826 |
Tinnitus | 41.85 | 10.00 | 135 | 102165 | 29907 | 56159860 |
Galactorrhoea | 41.66 | 10.00 | 43 | 102257 | 3852 | 56185915 |
Death | 41.66 | 10.00 | 408 | 101892 | 341018 | 55848749 |
Paranoia | 41.50 | 10.00 | 72 | 102228 | 10672 | 56179095 |
PCO2 increased | 41.27 | 10.00 | 26 | 102274 | 1142 | 56188625 |
Accidental poisoning | 40.84 | 10.00 | 21 | 102279 | 622 | 56189145 |
Logorrhoea | 40.79 | 10.00 | 34 | 102266 | 2318 | 56187449 |
Muscle disorder | 40.62 | 10.00 | 46 | 102254 | 4577 | 56185190 |
Fear | 40.45 | 10.00 | 86 | 102214 | 14822 | 56174945 |
Knee arthroplasty | 40.26 | 10.00 | 15 | 102285 | 44244 | 56145523 |
Hyperacusis | 40.09 | 10.00 | 31 | 102269 | 1897 | 56187870 |
Social anxiety disorder | 40.07 | 10.00 | 18 | 102282 | 392 | 56189375 |
COVID-19 | 39.37 | 10.00 | 47 | 102253 | 75011 | 56114756 |
Hostility | 39.30 | 10.00 | 30 | 102270 | 1801 | 56187966 |
Chorea | 39.11 | 10.00 | 27 | 102273 | 1385 | 56188382 |
Spina bifida | 39.02 | 10.00 | 22 | 102278 | 786 | 56188981 |
Incontinence | 38.96 | 10.00 | 70 | 102230 | 10665 | 56179102 |
Sinusitis | 38.72 | 10.00 | 206 | 102094 | 197375 | 55992392 |
Gastrointestinal disorder | 38.45 | 10.00 | 93 | 102207 | 112609 | 56077158 |
Tachycardia | 38.39 | 10.00 | 326 | 101974 | 105550 | 56084217 |
Blood creatine phosphokinase increased | 38.38 | 10.00 | 125 | 102175 | 27827 | 56161940 |
Hypoaesthesia oral | 38.28 | 10.00 | 72 | 102228 | 11359 | 56178408 |
Product complaint | 38.06 | 10.00 | 73 | 102227 | 11687 | 56178080 |
Libido decreased | 38.05 | 10.00 | 33 | 102267 | 2375 | 56187392 |
Congenital mitral valve stenosis | 37.19 | 10.00 | 7 | 102293 | 0 | 56189767 |
Amylase increased | 37.03 | 10.00 | 49 | 102251 | 5722 | 56184045 |
Restless legs syndrome | 36.26 | 10.00 | 89 | 102211 | 16858 | 56172909 |
Obsessive-compulsive disorder | 36.23 | 10.00 | 39 | 102261 | 3667 | 56186100 |
Neutropenia | 36.18 | 10.00 | 156 | 102144 | 158011 | 56031756 |
Rhonchi | 36.09 | 10.00 | 32 | 102268 | 2372 | 56187395 |
Seizure | 35.69 | 10.00 | 366 | 101934 | 124753 | 56065014 |
Psychomotor hyperactivity | 35.59 | 10.00 | 64 | 102236 | 9756 | 56180011 |
Dyspnoea | 35.42 | 10.00 | 814 | 101486 | 591763 | 55598004 |
Respiratory depression | 35.21 | 10.00 | 73 | 102227 | 12362 | 56177405 |
Injection site pain | 35.14 | 10.00 | 103 | 102197 | 117015 | 56072752 |
Emotional distress | 34.67 | 10.00 | 126 | 102174 | 29637 | 56160130 |
Urinary retention | 34.54 | 10.00 | 121 | 102179 | 27953 | 56161814 |
Loss of consciousness | 34.17 | 10.00 | 326 | 101974 | 109023 | 56080744 |
Neuropathy peripheral | 33.47 | 10.00 | 87 | 102213 | 102806 | 56086961 |
Ventricular hypoplasia | 33.38 | 10.00 | 12 | 102288 | 142 | 56189625 |
Electrocardiogram QT prolonged | 33.37 | 10.00 | 191 | 102109 | 54397 | 56135370 |
PO2 increased | 33.27 | 10.00 | 20 | 102280 | 807 | 56188960 |
Substance abuse | 33.10 | 10.00 | 41 | 102259 | 4484 | 56185283 |
Balance disorder | 32.87 | 10.00 | 245 | 102055 | 76275 | 56113492 |
Self-injurious ideation | 32.76 | 10.00 | 30 | 102270 | 2320 | 56187447 |
Hallucination, visual | 32.47 | 10.00 | 87 | 102213 | 17381 | 56172386 |
Maternal drugs affecting foetus | 32.31 | 10.00 | 43 | 102257 | 5050 | 56184717 |
Treatment noncompliance | 32.17 | 10.00 | 131 | 102169 | 32492 | 56157275 |
Disease progression | 31.91 | 10.00 | 92 | 102208 | 105081 | 56084686 |
Congenital aortic valve incompetence | 31.87 | 10.00 | 6 | 102294 | 0 | 56189767 |
DiGeorge's syndrome | 31.87 | 10.00 | 6 | 102294 | 0 | 56189767 |
Prescription form tampering | 31.52 | 10.00 | 17 | 102283 | 556 | 56189211 |
Toxic encephalopathy | 31.49 | 10.00 | 46 | 102254 | 5892 | 56183875 |
Fall | 31.08 | 10.00 | 860 | 101440 | 356650 | 55833117 |
Neonatal behavioural syndrome | 30.83 | 10.00 | 9 | 102291 | 51 | 56189716 |
Pain in extremity | 30.81 | 10.00 | 369 | 101931 | 297062 | 55892705 |
Paralysis | 30.38 | 10.00 | 57 | 102243 | 8975 | 56180792 |
Cerebral microhaemorrhage | 30.36 | 10.00 | 10 | 102290 | 89 | 56189678 |
Diabetes insipidus | 29.93 | 10.00 | 29 | 102271 | 2408 | 56187359 |
Hepatocellular injury | 29.83 | 10.00 | 111 | 102189 | 26403 | 56163364 |
Product dose omission issue | 29.65 | 10.00 | 234 | 102066 | 204519 | 55985248 |
Soft tissue injury | 29.58 | 10.00 | 24 | 102276 | 1575 | 56188192 |
Ebstein's anomaly | 29.20 | 10.00 | 7 | 102293 | 15 | 56189752 |
Joint hyperextension | 28.65 | 10.00 | 13 | 102287 | 290 | 56189477 |
Coma scale | 28.57 | 10.00 | 8 | 102292 | 38 | 56189729 |
Neutrophil count decreased | 28.54 | 10.00 | 29 | 102271 | 49793 | 56139974 |
Sepsis | 28.39 | 10.00 | 144 | 102156 | 139696 | 56050071 |
Encephalopathy | 28.10 | 10.00 | 133 | 102167 | 35192 | 56154575 |
Apraxia | 28.06 | 10.00 | 24 | 102276 | 1695 | 56188072 |
Injection site erythema | 27.95 | 10.00 | 62 | 102238 | 77386 | 56112381 |
Weight increased | 27.67 | 10.00 | 578 | 101722 | 229125 | 55960642 |
Cardiomegaly | 27.63 | 10.00 | 79 | 102221 | 16388 | 56173379 |
Feelings of worthlessness | 27.59 | 10.00 | 13 | 102287 | 317 | 56189450 |
Blood pH decreased | 27.52 | 10.00 | 28 | 102272 | 2466 | 56187301 |
Electroencephalogram abnormal | 27.40 | 10.00 | 33 | 102267 | 3506 | 56186261 |
Soliloquy | 27.25 | 10.00 | 11 | 102289 | 182 | 56189585 |
Sensory disturbance | 26.97 | 10.00 | 66 | 102234 | 12477 | 56177290 |
Mental disorder | 26.71 | 10.00 | 99 | 102201 | 23505 | 56166262 |
Micrognathia | 26.69 | 10.00 | 12 | 102288 | 262 | 56189505 |
Asphyxia | 26.67 | 10.00 | 42 | 102258 | 5747 | 56184020 |
Musculoskeletal stiffness | 26.63 | 10.00 | 170 | 102130 | 155837 | 56033930 |
Bradykinesia | 26.32 | 10.00 | 38 | 102262 | 4816 | 56184951 |
Hot flush | 26.31 | 10.00 | 160 | 102140 | 46566 | 56143201 |
Bronchopulmonary dysplasia | 26.19 | 10.00 | 12 | 102288 | 274 | 56189493 |
Vesicoureteric reflux | 26.01 | 10.00 | 11 | 102289 | 206 | 56189561 |
Cardio-respiratory arrest | 25.99 | 10.00 | 181 | 102119 | 55140 | 56134627 |
Personality disorder | 25.89 | 10.00 | 39 | 102261 | 5134 | 56184633 |
Therapy non-responder | 25.69 | 10.00 | 45 | 102255 | 61310 | 56128457 |
Arthritis | 25.67 | 10.00 | 94 | 102206 | 99758 | 56090009 |
Blood sodium decreased | 25.55 | 10.00 | 94 | 102206 | 22240 | 56167527 |
Creutzfeldt-Jakob disease | 25.43 | 10.00 | 10 | 102290 | 154 | 56189613 |
Post-traumatic neck syndrome | 25.16 | 10.00 | 24 | 102276 | 1954 | 56187813 |
Vision blurred | 24.79 | 10.00 | 245 | 102055 | 82698 | 56107069 |
Dysmorphism | 24.70 | 10.00 | 25 | 102275 | 2188 | 56187579 |
Compartment syndrome | 24.70 | 10.00 | 24 | 102276 | 2000 | 56187767 |
Obsessive thoughts | 24.69 | 10.00 | 14 | 102286 | 506 | 56189261 |
Tricuspid valve incompetence | 24.63 | 10.00 | 66 | 102234 | 13187 | 56176580 |
Congenital heart valve disorder | 24.31 | 10.00 | 8 | 102292 | 71 | 56189696 |
Macular degeneration | 24.05 | 10.00 | 3 | 102297 | 18905 | 56170862 |
Panic disorder | 23.98 | 10.00 | 26 | 102274 | 2465 | 56187302 |
Middle insomnia | 23.95 | 10.00 | 58 | 102242 | 10892 | 56178875 |
Congenital tricuspid valve atresia | 23.93 | 10.00 | 7 | 102293 | 40 | 56189727 |
Eye movement disorder | 23.82 | 10.00 | 36 | 102264 | 4753 | 56185014 |
Panic reaction | 23.78 | 10.00 | 32 | 102268 | 3798 | 56185969 |
Blood lactate dehydrogenase increased | 23.63 | 10.00 | 87 | 102213 | 20588 | 56169179 |
Anorgasmia | 23.60 | 10.00 | 14 | 102286 | 551 | 56189216 |
Aortic valve incompetence | 23.51 | 10.00 | 39 | 102261 | 5573 | 56184194 |
Psychiatric symptom | 23.51 | 10.00 | 36 | 102264 | 4808 | 56184959 |
Hepatotoxicity | 23.06 | 10.00 | 14 | 102286 | 31139 | 56158628 |
Aorta hypoplasia | 23.04 | 10.00 | 9 | 102291 | 136 | 56189631 |
Alcoholism | 22.93 | 10.00 | 24 | 102276 | 2185 | 56187582 |
Cleft lip and palate | 22.66 | 10.00 | 12 | 102288 | 378 | 56189389 |
Oxygen saturation abnormal | 22.43 | 10.00 | 27 | 102273 | 2867 | 56186900 |
Cytomegalovirus infection | 22.39 | 10.00 | 4 | 102296 | 19292 | 56170475 |
Mood altered | 22.34 | 10.00 | 64 | 102236 | 13291 | 56176476 |
Pyrexia | 22.29 | 10.00 | 585 | 101715 | 418188 | 55771579 |
Phonophobia | 22.25 | 10.00 | 11 | 102289 | 299 | 56189468 |
Poor quality sleep | 22.25 | 10.00 | 77 | 102223 | 17678 | 56172089 |
Tension | 22.21 | 10.00 | 27 | 102273 | 2897 | 56186870 |
Major depression | 22.03 | 10.00 | 45 | 102255 | 7539 | 56182228 |
Altered visual depth perception | 21.83 | 10.00 | 11 | 102289 | 312 | 56189455 |
Dilatation ventricular | 21.80 | 10.00 | 24 | 102276 | 2314 | 56187453 |
Musculoskeletal pain | 21.79 | 10.00 | 75 | 102225 | 81077 | 56108690 |
Generalised anxiety disorder | 21.77 | 10.00 | 22 | 102278 | 1922 | 56187845 |
Pulmonary artery stenosis | 21.76 | 10.00 | 9 | 102291 | 159 | 56189608 |
Myelosuppression | 21.65 | 10.00 | 3 | 102297 | 17452 | 56172315 |
White blood cell count decreased | 21.64 | 10.00 | 137 | 102163 | 125853 | 56063914 |
Hypoplastic right heart syndrome | 21.59 | 10.00 | 7 | 102293 | 59 | 56189708 |
Ventricular hypertrophy | 21.56 | 10.00 | 28 | 102272 | 3210 | 56186557 |
Blood triglycerides increased | 21.54 | 10.00 | 58 | 102242 | 11619 | 56178148 |
Anaphylactic reaction | 21.47 | 10.00 | 47 | 102253 | 58948 | 56130819 |
Coma | 21.25 | 10.00 | 183 | 102117 | 59472 | 56130295 |
Pilonidal cyst congenital | 21.25 | 10.00 | 4 | 102296 | 0 | 56189767 |
Congenital aortic atresia | 21.25 | 10.00 | 4 | 102296 | 0 | 56189767 |
Sinus tachycardia | 21.24 | 10.00 | 89 | 102211 | 22355 | 56167412 |
Hypokinesia | 21.07 | 10.00 | 61 | 102239 | 12742 | 56177025 |
Poisoning | 21.04 | 10.00 | 61 | 102239 | 12752 | 56177015 |
Somnolence neonatal | 21.04 | 10.00 | 8 | 102292 | 112 | 56189655 |
Joint range of motion decreased | 20.82 | 10.00 | 10 | 102290 | 25355 | 56164412 |
Euphoric mood | 20.61 | 10.00 | 32 | 102268 | 4326 | 56185441 |
Pancytopenia | 20.58 | 10.00 | 87 | 102213 | 88628 | 56101139 |
Fibromyalgia | 20.47 | 10.00 | 49 | 102251 | 59554 | 56130213 |
Sternal fracture | 20.44 | 10.00 | 22 | 102278 | 2068 | 56187699 |
Wolff-Parkinson-White syndrome | 20.42 | 10.00 | 8 | 102292 | 122 | 56189645 |
Sleep disorder | 20.28 | 10.00 | 200 | 102100 | 67463 | 56122304 |
Sensory loss | 20.27 | 10.00 | 48 | 102252 | 8887 | 56180880 |
Mucosal inflammation | 20.19 | 10.00 | 29 | 102271 | 42781 | 56146986 |
Metastases to liver | 20.17 | 10.00 | 7 | 102293 | 21579 | 56168188 |
Dysarthria | 20.13 | 10.00 | 132 | 102168 | 39418 | 56150349 |
Negative thoughts | 20.09 | 10.00 | 15 | 102285 | 871 | 56188896 |
Endocrine ophthalmopathy | 19.70 | 10.00 | 12 | 102288 | 496 | 56189271 |
Pneumonitis | 19.70 | 10.00 | 17 | 102283 | 31547 | 56158220 |
Physical assault | 19.64 | 10.00 | 15 | 102285 | 901 | 56188866 |
Aphasia | 19.63 | 10.00 | 108 | 102192 | 30307 | 56159460 |
Feeling abnormal | 19.41 | 10.00 | 346 | 101954 | 133256 | 56056511 |
Hypertonia | 19.28 | 10.00 | 30 | 102270 | 4062 | 56185705 |
Schizophrenia | 19.22 | 10.00 | 52 | 102248 | 10447 | 56179320 |
Posterior reversible encephalopathy syndrome | 19.20 | 10.00 | 3 | 102297 | 15957 | 56173810 |
Antidepressant discontinuation syndrome | 19.18 | 10.00 | 5 | 102295 | 17 | 56189750 |
Troponin increased | 19.17 | 10.00 | 46 | 102254 | 8589 | 56181178 |
Failure to thrive | 19.11 | 10.00 | 39 | 102261 | 6531 | 56183236 |
Condition aggravated | 19.09 | 10.00 | 479 | 101821 | 344419 | 55845348 |
Wrong patient | 18.95 | 10.00 | 8 | 102292 | 149 | 56189618 |
Premature baby | 18.84 | 10.00 | 77 | 102223 | 19128 | 56170639 |
Increased appetite | 18.82 | 10.00 | 46 | 102254 | 8689 | 56181078 |
Plagiocephaly | 18.78 | 10.00 | 6 | 102294 | 48 | 56189719 |
Blood bicarbonate decreased | 18.69 | 10.00 | 24 | 102276 | 2722 | 56187045 |
Bipolar disorder | 18.60 | 10.00 | 42 | 102258 | 7538 | 56182229 |
Right ventricle outflow tract obstruction | 18.48 | 10.00 | 4 | 102296 | 4 | 56189763 |
Foetal movement disorder | 18.48 | 10.00 | 4 | 102296 | 4 | 56189763 |
Velopharyngeal incompetence | 18.36 | 10.00 | 5 | 102295 | 21 | 56189746 |
Psychomotor skills impaired | 18.30 | 10.00 | 21 | 102279 | 2119 | 56187648 |
Mitral valve incompetence | 17.98 | 10.00 | 73 | 102227 | 18080 | 56171687 |
Hypotonia | 17.96 | 10.00 | 45 | 102255 | 8632 | 56181135 |
Plasma cell myeloma | 17.95 | 10.00 | 36 | 102264 | 46610 | 56143157 |
Frontotemporal dementia | 17.92 | 10.00 | 10 | 102290 | 350 | 56189417 |
Drug abuser | 17.92 | 10.00 | 24 | 102276 | 2835 | 56186932 |
Therapeutic product effect incomplete | 17.85 | 10.00 | 116 | 102184 | 105915 | 56083852 |
Apnoea | 17.63 | 10.00 | 40 | 102260 | 7202 | 56182565 |
Impatience | 17.62 | 10.00 | 10 | 102290 | 362 | 56189405 |
Bradycardia | 17.61 | 10.00 | 194 | 102106 | 67310 | 56122457 |
Mental impairment | 17.56 | 10.00 | 57 | 102243 | 12665 | 56177102 |
Blepharospasm | 17.55 | 10.00 | 26 | 102274 | 3372 | 56186395 |
Congenital aortic anomaly | 17.42 | 10.00 | 6 | 102294 | 62 | 56189705 |
Toxic shock syndrome | 17.41 | 10.00 | 12 | 102288 | 614 | 56189153 |
Injection site reaction | 17.33 | 10.00 | 45 | 102255 | 53202 | 56136565 |
Pruritus | 17.17 | 10.00 | 441 | 101859 | 316182 | 55873585 |
Pulmonary valve incompetence | 17.14 | 10.00 | 16 | 102284 | 1268 | 56188499 |
Hospitalisation | 17.12 | 10.00 | 74 | 102226 | 74926 | 56114841 |
Upper respiratory tract infection | 17.10 | 10.00 | 69 | 102231 | 71219 | 56118548 |
Back pain | 16.99 | 10.00 | 316 | 101984 | 236854 | 55952913 |
Trichotillomania | 16.96 | 10.00 | 7 | 102293 | 123 | 56189644 |
Adverse drug reaction | 16.94 | 10.00 | 61 | 102239 | 65071 | 56124696 |
Slow response to stimuli | 16.85 | 10.00 | 14 | 102286 | 950 | 56188817 |
Leukopenia | 16.81 | 10.00 | 69 | 102231 | 70871 | 56118896 |
Otospondylomegaepiphyseal dysplasia | 16.77 | 10.00 | 6 | 102294 | 70 | 56189697 |
Disinhibition | 16.64 | 10.00 | 13 | 102287 | 808 | 56188959 |
Campylobacter colitis | 16.61 | 10.00 | 5 | 102295 | 32 | 56189735 |
Antisocial personality disorder | 16.55 | 10.00 | 4 | 102296 | 9 | 56189758 |
Cleft uvula | 16.55 | 10.00 | 4 | 102296 | 9 | 56189758 |
Parkinson's disease | 16.52 | 10.00 | 16 | 102284 | 1328 | 56188439 |
Illusion | 16.48 | 10.00 | 14 | 102286 | 980 | 56188787 |
Social avoidant behaviour | 16.46 | 10.00 | 23 | 102277 | 2829 | 56186938 |
Psoriasis | 16.33 | 10.00 | 100 | 102200 | 92592 | 56097175 |
Myoglobin blood increased | 16.32 | 10.00 | 16 | 102284 | 1348 | 56188419 |
Poriomania | 16.18 | 10.00 | 6 | 102294 | 78 | 56189689 |
Congenital tracheomalacia | 16.11 | 10.00 | 5 | 102295 | 36 | 56189731 |
Cognitive disorder | 16.10 | 10.00 | 148 | 102152 | 48985 | 56140782 |
Feeling guilty | 16.08 | 10.00 | 11 | 102289 | 556 | 56189211 |
Oropharyngeal pain | 16.04 | 10.00 | 88 | 102212 | 83700 | 56106067 |
Ear infection | 15.98 | 10.00 | 20 | 102280 | 31275 | 56158492 |
Lipomeningocele | 15.94 | 10.00 | 3 | 102297 | 0 | 56189767 |
Interruption of aortic arch | 15.94 | 10.00 | 3 | 102297 | 0 | 56189767 |
Subvalvular aortic stenosis | 15.94 | 10.00 | 3 | 102297 | 0 | 56189767 |
Tethered cord syndrome | 15.87 | 10.00 | 8 | 102292 | 227 | 56189540 |
Therapy interrupted | 15.75 | 10.00 | 14 | 102286 | 25611 | 56164156 |
Delivery | 15.72 | 10.00 | 13 | 102287 | 876 | 56188891 |
Product use in unapproved indication | 15.61 | 10.00 | 172 | 102128 | 140650 | 56049117 |
Drug resistance | 15.53 | 10.00 | 9 | 102291 | 20533 | 56169234 |
Congenital scoliosis | 15.49 | 10.00 | 4 | 102296 | 13 | 56189754 |
Autoimmune nephritis | 15.39 | 10.00 | 9 | 102291 | 345 | 56189422 |
Premature labour | 15.30 | 10.00 | 52 | 102248 | 11830 | 56177937 |
Brugada syndrome | 15.30 | 10.00 | 9 | 102291 | 349 | 56189418 |
Granuloma | 15.29 | 10.00 | 32 | 102268 | 5455 | 56184312 |
Trismus | 15.28 | 10.00 | 25 | 102275 | 3533 | 56186234 |
Generalised tonic-clonic seizure | 15.27 | 10.00 | 94 | 102206 | 27472 | 56162295 |
Inflammation | 15.25 | 10.00 | 69 | 102231 | 69002 | 56120765 |
Post procedural haematuria | 15.23 | 10.00 | 5 | 102295 | 44 | 56189723 |
Foetal death | 15.19 | 10.00 | 42 | 102258 | 8545 | 56181222 |
Anhedonia | 15.14 | 10.00 | 46 | 102254 | 9868 | 56179899 |
Atrioventricular septal defect | 15.08 | 10.00 | 8 | 102292 | 253 | 56189514 |
Thinking abnormal | 15.06 | 10.00 | 46 | 102254 | 9895 | 56179872 |
VACTERL syndrome | 15.04 | 10.00 | 4 | 102296 | 15 | 56189752 |
Diabetic hyperosmolar coma | 15.04 | 10.00 | 9 | 102291 | 360 | 56189407 |
Perseveration | 15.02 | 10.00 | 8 | 102292 | 255 | 56189512 |
Arnold-Chiari malformation | 14.97 | 10.00 | 11 | 102289 | 623 | 56189144 |
Injection site pruritus | 14.77 | 10.00 | 34 | 102266 | 41897 | 56147870 |
Urticaria | 14.75 | 10.00 | 180 | 102120 | 144496 | 56045271 |
Diarrhoea | 14.63 | 10.00 | 982 | 101318 | 637525 | 55552242 |
Oedema | 14.63 | 10.00 | 88 | 102212 | 81832 | 56107935 |
Lactose intolerance | 14.61 | 10.00 | 21 | 102279 | 2651 | 56187116 |
Gaze palsy | 14.57 | 10.00 | 15 | 102285 | 1340 | 56188427 |
Alcohol abuse | 14.55 | 10.00 | 18 | 102282 | 1966 | 56187801 |
Localised infection | 14.54 | 10.00 | 17 | 102283 | 27395 | 56162372 |
Anaemia | 14.39 | 10.00 | 373 | 101927 | 267138 | 55922629 |
Antipsychotic drug level above therapeutic | 14.39 | 10.00 | 13 | 102287 | 988 | 56188779 |
Oesophageal atresia | 14.37 | 10.00 | 10 | 102290 | 520 | 56189247 |
Female orgasmic disorder | 14.32 | 10.00 | 5 | 102295 | 54 | 56189713 |
Amimia | 14.32 | 10.00 | 5 | 102295 | 54 | 56189713 |
Nodule | 14.30 | 10.00 | 8 | 102292 | 18611 | 56171156 |
Neonatal asphyxia | 14.16 | 10.00 | 8 | 102292 | 287 | 56189480 |
Premature delivery | 14.12 | 10.00 | 17 | 102283 | 27043 | 56162724 |
Rhabdomyolysis | 14.10 | 10.00 | 124 | 102176 | 40534 | 56149233 |
Tardive dyskinesia | 13.93 | 10.00 | 39 | 102261 | 7992 | 56181775 |
Marcus Gunn syndrome | 13.86 | 10.00 | 3 | 102297 | 3 | 56189764 |
Leucine aminopeptidase increased | 13.86 | 10.00 | 3 | 102297 | 3 | 56189764 |
Dyskinesia neonatal | 13.86 | 10.00 | 3 | 102297 | 3 | 56189764 |
Yawning | 13.82 | 10.00 | 13 | 102287 | 1040 | 56188727 |
Sacroiliac joint dysfunction | 13.80 | 10.00 | 4 | 102296 | 22 | 56189745 |
Muscle contracture | 13.79 | 10.00 | 14 | 102286 | 1230 | 56188537 |
Resting tremor | 13.65 | 10.00 | 11 | 102289 | 715 | 56189052 |
Tenosynovitis | 13.58 | 10.00 | 3 | 102297 | 12458 | 56177309 |
Tri-iodothyronine free decreased | 13.58 | 10.00 | 8 | 102292 | 311 | 56189456 |
Intentional device use issue | 13.55 | 10.00 | 5 | 102295 | 64 | 56189703 |
Glossoptosis | 13.48 | 10.00 | 5 | 102295 | 65 | 56189702 |
Oscillopsia | 13.26 | 10.00 | 6 | 102294 | 133 | 56189634 |
Clostridium difficile infection | 13.25 | 10.00 | 18 | 102282 | 27180 | 56162587 |
Eyelid disorder | 13.14 | 10.00 | 15 | 102285 | 1506 | 56188261 |
Suicidal behaviour | 13.12 | 10.00 | 19 | 102281 | 2414 | 56187353 |
Oculogyric crisis | 13.11 | 10.00 | 15 | 102285 | 1509 | 56188258 |
Abdominal pain | 13.10 | 10.00 | 364 | 101936 | 258441 | 55931326 |
Poor sucking reflex | 13.06 | 10.00 | 7 | 102293 | 226 | 56189541 |
Serum sickness-like reaction | 13.01 | 10.00 | 9 | 102291 | 463 | 56189304 |
Respiratory tract infection | 12.91 | 10.00 | 29 | 102271 | 36042 | 56153725 |
Dairy intolerance | 12.90 | 10.00 | 5 | 102295 | 74 | 56189693 |
Dextrocardia | 12.86 | 10.00 | 4 | 102296 | 29 | 56189738 |
Genital labial adhesions | 12.86 | 10.00 | 4 | 102296 | 29 | 56189738 |
Cholecystitis chronic | 12.85 | 10.00 | 43 | 102257 | 9705 | 56180062 |
Right aortic arch | 12.76 | 10.00 | 7 | 102293 | 237 | 56189530 |
Aortic stenosis | 12.74 | 10.00 | 26 | 102274 | 4354 | 56185413 |
Muscle tightness | 12.72 | 10.00 | 46 | 102254 | 10790 | 56178977 |
Asplenia | 12.65 | 10.00 | 3 | 102297 | 6 | 56189761 |
Congenital neurological disorder | 12.65 | 10.00 | 3 | 102297 | 6 | 56189761 |
Decreased activity | 12.63 | 10.00 | 30 | 102270 | 5566 | 56184201 |
Ear pain | 12.62 | 10.00 | 23 | 102277 | 30867 | 56158900 |
Ill-defined disorder | 12.57 | 10.00 | 73 | 102227 | 68470 | 56121297 |
Apallic syndrome | 12.57 | 10.00 | 10 | 102290 | 638 | 56189129 |
Visual impairment | 12.54 | 10.00 | 197 | 102103 | 74005 | 56115762 |
Delusion of grandeur | 12.49 | 10.00 | 6 | 102294 | 153 | 56189614 |
Aeromonas infection | 12.48 | 10.00 | 5 | 102295 | 81 | 56189686 |
Atrial fibrillation | 12.47 | 10.00 | 132 | 102168 | 108765 | 56081002 |
Grip strength decreased | 12.47 | 10.00 | 7 | 102293 | 16249 | 56173518 |
Laboratory test abnormal | 12.38 | 10.00 | 16 | 102284 | 24679 | 56165088 |
Spina bifida occulta | 12.34 | 10.00 | 3 | 102297 | 7 | 56189760 |
Coronary artery disease | 12.32 | 10.00 | 97 | 102203 | 30699 | 56159068 |
Dermatitis allergic | 12.28 | 10.00 | 5 | 102295 | 13973 | 56175794 |
Antiphospholipid antibodies | 12.24 | 10.00 | 6 | 102294 | 160 | 56189607 |
Marital problem | 12.18 | 10.00 | 6 | 102294 | 162 | 56189605 |
Sexual dysfunction | 12.17 | 10.00 | 22 | 102278 | 3366 | 56186401 |
Intestinal infarction | 12.16 | 10.00 | 12 | 102288 | 1019 | 56188748 |
Infusion site scar | 12.16 | 10.00 | 8 | 102292 | 379 | 56189388 |
Accidental overdose | 12.11 | 10.00 | 71 | 102229 | 20390 | 56169377 |
Anal atresia | 12.08 | 10.00 | 8 | 102292 | 383 | 56189384 |
Drug-disease interaction | 12.02 | 10.00 | 8 | 102292 | 386 | 56189381 |
Dissociative disorder | 12 | 10.00 | 7 | 102293 | 267 | 56189500 |
Intra-abdominal haematoma | 11.98 | 10.00 | 15 | 102285 | 1659 | 56188108 |
Inferior vena caval occlusion | 11.79 | 10.00 | 3 | 102297 | 9 | 56189758 |
Paroxysmal arrhythmia | 11.73 | 10.00 | 4 | 102296 | 40 | 56189727 |
Urinary tract infection | 11.73 | 10.00 | 340 | 101960 | 240173 | 55949594 |
Pneumocystis jirovecii pneumonia | 11.70 | 10.00 | 7 | 102293 | 15694 | 56174073 |
Hypoosmolar state | 11.69 | 10.00 | 6 | 102294 | 177 | 56189590 |
Posture abnormal | 11.62 | 10.00 | 17 | 102283 | 2181 | 56187586 |
Congenital coronary artery malformation | 11.57 | 10.00 | 5 | 102295 | 99 | 56189668 |
Abdominal wall cyst | 11.56 | 10.00 | 4 | 102296 | 42 | 56189725 |
Pharyngitis | 11.55 | 10.00 | 10 | 102290 | 18528 | 56171239 |
Colitis microscopic | 11.52 | 10.00 | 36 | 102264 | 7839 | 56181928 |
Osteoporosis | 11.49 | 10.00 | 52 | 102248 | 52000 | 56137767 |
Hypercapnic coma | 11.48 | 10.00 | 6 | 102294 | 184 | 56189583 |
Double outlet right ventricle | 11.47 | 10.00 | 4 | 102296 | 43 | 56189724 |
Blood pressure systolic increased | 11.47 | 10.00 | 37 | 102263 | 40799 | 56148968 |
Cystocele | 11.39 | 10.00 | 12 | 102288 | 1101 | 56188666 |
Hyperventilation | 11.39 | 10.00 | 29 | 102271 | 5619 | 56184148 |
Platelet count decreased | 11.36 | 10.00 | 131 | 102169 | 106252 | 56083515 |
Diet refusal | 11.30 | 10.00 | 9 | 102291 | 575 | 56189192 |
Device expulsion | 11.29 | 10.00 | 24 | 102276 | 30425 | 56159342 |
Blood aldosterone abnormal | 11.23 | 10.00 | 4 | 102296 | 46 | 56189721 |
Diverticulitis | 11.13 | 10.00 | 31 | 102269 | 35821 | 56153946 |
Ankle fracture | 11.09 | 10.00 | 59 | 102241 | 16344 | 56173423 |
Parkinsonian gait | 11.02 | 10.00 | 8 | 102292 | 445 | 56189322 |
Drowning | 10.97 | 10.00 | 8 | 102292 | 448 | 56189319 |
Blood cholinesterase decreased | 10.96 | 10.00 | 5 | 102295 | 113 | 56189654 |
Persecutory delusion | 10.96 | 10.00 | 18 | 102282 | 2552 | 56187215 |
Congenital pulmonary valve disorder | 10.93 | 10.00 | 4 | 102296 | 50 | 56189717 |
Obstructive airways disorder | 10.91 | 10.00 | 61 | 102239 | 17221 | 56172546 |
Thrombocytopenia | 10.87 | 10.00 | 178 | 102122 | 136046 | 56053721 |
Congenital diaphragmatic hernia | 10.81 | 10.00 | 6 | 102294 | 208 | 56189559 |
Palpitations | 10.76 | 10.00 | 247 | 102053 | 99425 | 56090342 |
Eyelid haematoma | 10.76 | 10.00 | 3 | 102297 | 14 | 56189753 |
Dizziness postural | 10.73 | 10.00 | 31 | 102269 | 6467 | 56183300 |
Head titubation | 10.73 | 10.00 | 10 | 102290 | 791 | 56188976 |
Reversible cerebral vasoconstriction syndrome | 10.61 | 10.00 | 17 | 102283 | 2360 | 56187407 |
Congenital eye disorder | 10.59 | 10.00 | 3 | 102297 | 15 | 56189752 |
Posturing | 10.59 | 10.00 | 8 | 102292 | 473 | 56189294 |
Scratch | 10.51 | 10.00 | 28 | 102272 | 5575 | 56184192 |
Mutism | 10.51 | 10.00 | 13 | 102287 | 1420 | 56188347 |
Mouth ulceration | 10.47 | 10.00 | 24 | 102276 | 29616 | 56160151 |
Hydrocephalus | 10.46 | 10.00 | 26 | 102274 | 4963 | 56184804 |
Housebound | 10.45 | 10.00 | 6 | 102294 | 222 | 56189545 |
Left ventricular dysfunction | 10.44 | 10.00 | 44 | 102256 | 11079 | 56178688 |
Hyperthermia | 10.44 | 10.00 | 36 | 102264 | 8249 | 56181518 |
Normetanephrine urine increased | 10.43 | 10.00 | 3 | 102297 | 16 | 56189751 |
Electric shock sensation | 10.35 | 10.00 | 8 | 102292 | 489 | 56189278 |
Laryngomalacia | 10.33 | 10.00 | 4 | 102296 | 59 | 56189708 |
Anxiety disorder | 10.32 | 10.00 | 22 | 102278 | 3798 | 56185969 |
Blood pressure diastolic decreased | 10.23 | 10.00 | 12 | 102288 | 19311 | 56170456 |
Bundle branch block right | 10.23 | 10.00 | 25 | 102275 | 4722 | 56185045 |
Palmar-plantar erythrodysaesthesia syndrome | 10.20 | 10.00 | 14 | 102286 | 21051 | 56168716 |
Dyslipidaemia | 10.19 | 10.00 | 30 | 102270 | 6323 | 56183444 |
Hypochloraemia | 10.17 | 10.00 | 14 | 102286 | 1698 | 56188069 |
Prescription drug used without a prescription | 10.01 | 10.00 | 15 | 102285 | 1965 | 56187802 |
Septic shock | 10.01 | 10.00 | 67 | 102233 | 60768 | 56128999 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 1806.20 | 11.22 | 638 | 51827 | 7960 | 31636919 |
Atrial septal defect | 808.02 | 11.22 | 335 | 52130 | 6592 | 31638287 |
Ventricular septal defect | 554.33 | 11.22 | 214 | 52251 | 3463 | 31641416 |
Patent ductus arteriosus | 485.49 | 11.22 | 187 | 52278 | 3006 | 31641873 |
Drug withdrawal syndrome | 398.75 | 11.22 | 294 | 52171 | 18456 | 31626423 |
Foetal exposure during pregnancy | 390.26 | 11.22 | 406 | 52059 | 40470 | 31604409 |
Cardiac murmur | 351.06 | 11.22 | 187 | 52278 | 6575 | 31638304 |
Congenital anomaly | 306.60 | 11.22 | 106 | 52359 | 1229 | 31643650 |
Suicidal ideation | 298.95 | 11.22 | 334 | 52131 | 36072 | 31608807 |
Serotonin syndrome | 265.87 | 11.22 | 232 | 52233 | 18541 | 31626338 |
Anxiety | 264.97 | 11.22 | 511 | 51954 | 90522 | 31554357 |
Heart disease congenital | 249.62 | 11.22 | 91 | 52374 | 1244 | 31643635 |
Multiple congenital abnormalities | 248.55 | 11.22 | 73 | 52392 | 473 | 31644406 |
Suicide attempt | 240.06 | 11.22 | 302 | 52163 | 36946 | 31607933 |
Pulmonary valve stenosis | 231.10 | 11.22 | 63 | 52402 | 298 | 31644581 |
Depression | 231.00 | 11.22 | 482 | 51983 | 90333 | 31554546 |
Talipes | 220.98 | 11.22 | 91 | 52374 | 1755 | 31643124 |
Aggression | 220.91 | 11.22 | 290 | 52175 | 37001 | 31607878 |
Irritability | 206.96 | 11.22 | 221 | 52244 | 22668 | 31622211 |
Coarctation of the aorta | 187.98 | 11.22 | 57 | 52408 | 418 | 31644461 |
Completed suicide | 176.14 | 11.22 | 435 | 52030 | 91079 | 31553800 |
Persistent foetal circulation | 169.75 | 11.22 | 49 | 52416 | 296 | 31644583 |
Bicuspid aortic valve | 162.17 | 11.22 | 43 | 52422 | 179 | 31644700 |
Hypoplastic left heart syndrome | 159.38 | 11.22 | 43 | 52422 | 194 | 31644685 |
Pulmonary artery stenosis congenital | 157.31 | 11.22 | 50 | 52415 | 436 | 31644443 |
Fallot's tetralogy | 149.12 | 11.22 | 39 | 52426 | 152 | 31644727 |
Transposition of the great vessels | 126.76 | 11.22 | 42 | 52423 | 423 | 31644456 |
Agitation | 126.58 | 11.22 | 278 | 52187 | 53891 | 31590988 |
Intentional self-injury | 119.33 | 11.22 | 128 | 52337 | 13187 | 31631692 |
Congenital aortic stenosis | 116.97 | 11.22 | 28 | 52437 | 68 | 31644811 |
Panic attack | 112.13 | 11.22 | 102 | 52363 | 8601 | 31636278 |
Mania | 111.34 | 11.22 | 104 | 52361 | 9073 | 31635806 |
Extrapyramidal disorder | 106.91 | 11.22 | 114 | 52351 | 11664 | 31633215 |
Tremor | 106.67 | 11.22 | 323 | 52142 | 76097 | 31568782 |
Off label use | 106.32 | 11.22 | 264 | 52201 | 347010 | 31297869 |
Insomnia | 105.52 | 11.22 | 371 | 52094 | 94465 | 31550414 |
Impulsive behaviour | 102.57 | 11.22 | 55 | 52410 | 1958 | 31642921 |
Craniosynostosis | 97.23 | 11.22 | 32 | 52433 | 315 | 31644564 |
Febrile neutropenia | 97.22 | 11.22 | 40 | 52425 | 121809 | 31523070 |
Developmental delay | 97.09 | 11.22 | 58 | 52407 | 2547 | 31642332 |
Disturbance in attention | 96.60 | 11.22 | 150 | 52315 | 22300 | 31622579 |
Activation syndrome | 95.85 | 11.22 | 24 | 52441 | 75 | 31644804 |
Drug abuse | 93.92 | 11.22 | 339 | 52126 | 87419 | 31557460 |
Neuroleptic malignant syndrome | 90.38 | 11.22 | 125 | 52340 | 16744 | 31628135 |
Sopor | 89.64 | 11.22 | 103 | 52362 | 11449 | 31633430 |
Intentional overdose | 85.11 | 11.22 | 202 | 52263 | 41187 | 31603692 |
Coma | 84.80 | 11.22 | 201 | 52264 | 40949 | 31603930 |
Congenital cardiovascular anomaly | 83.57 | 11.22 | 25 | 52440 | 174 | 31644705 |
Homicide | 82.12 | 11.22 | 37 | 52428 | 895 | 31643984 |
Poisoning deliberate | 81.06 | 11.22 | 79 | 52386 | 7265 | 31637614 |
Pneumonia | 78.10 | 11.22 | 289 | 52176 | 335023 | 31309856 |
Somnolence | 76.71 | 11.22 | 347 | 52118 | 99098 | 31545781 |
Anger | 75.89 | 11.22 | 93 | 52372 | 11060 | 31633819 |
Withdrawal syndrome | 75.40 | 11.22 | 95 | 52370 | 11622 | 31633257 |
Acute kidney injury | 74.01 | 11.22 | 228 | 52237 | 279486 | 31365393 |
Death | 71.37 | 11.22 | 331 | 52134 | 360238 | 31284641 |
Sleep disorder | 69.34 | 11.22 | 142 | 52323 | 26206 | 31618673 |
Double outlet right ventricle | 68.82 | 11.22 | 19 | 52446 | 95 | 31644784 |
Cleft lip and palate | 65.60 | 11.22 | 26 | 52439 | 452 | 31644427 |
Congenital aortic atresia | 65.51 | 11.22 | 14 | 52451 | 15 | 31644864 |
Pulmonary malformation | 60.02 | 11.22 | 14 | 52451 | 29 | 31644850 |
Mood swings | 58.95 | 11.22 | 67 | 52398 | 7357 | 31637522 |
Confusional state | 58.88 | 11.22 | 400 | 52065 | 132934 | 31511945 |
Hypoplastic right heart syndrome | 57.61 | 11.22 | 12 | 52453 | 10 | 31644869 |
Tricuspid valve incompetence | 57.46 | 11.22 | 72 | 52393 | 8757 | 31636122 |
Sexual dysfunction | 56.35 | 11.22 | 59 | 52406 | 5909 | 31638970 |
Cleft palate | 55.55 | 11.22 | 25 | 52440 | 603 | 31644276 |
Inappropriate antidiuretic hormone secretion | 54.54 | 11.22 | 80 | 52385 | 11307 | 31633572 |
Speech disorder developmental | 54.14 | 11.22 | 37 | 52428 | 2054 | 31642825 |
Sepsis | 54.10 | 11.22 | 106 | 52359 | 151823 | 31493056 |
Drug ineffective | 53.88 | 11.22 | 409 | 52056 | 395164 | 31249715 |
Drug withdrawal syndrome neonatal | 51.11 | 11.22 | 44 | 52421 | 3448 | 31641431 |
Hyperhidrosis | 51.05 | 11.22 | 234 | 52231 | 67159 | 31577720 |
Nervousness | 50.96 | 11.22 | 79 | 52386 | 11721 | 31633158 |
Dyspnoea | 48.71 | 11.22 | 351 | 52114 | 343128 | 31301751 |
Cogwheel rigidity | 48.59 | 11.22 | 29 | 52436 | 1271 | 31643608 |
Head titubation | 48.27 | 11.22 | 19 | 52446 | 324 | 31644555 |
Anticholinergic syndrome | 47.91 | 11.22 | 27 | 52438 | 1061 | 31643818 |
Pulmonary valve stenosis congenital | 47.89 | 11.22 | 15 | 52450 | 124 | 31644755 |
Plagiocephaly | 46.49 | 11.22 | 21 | 52444 | 511 | 31644368 |
Hamartoma | 46.46 | 11.22 | 12 | 52453 | 44 | 31644835 |
Erectile dysfunction | 46.33 | 11.22 | 100 | 52365 | 19135 | 31625744 |
Congenital aortic valve incompetence | 46.00 | 11.22 | 15 | 52450 | 143 | 31644736 |
Overdose | 45.41 | 11.22 | 267 | 52198 | 84397 | 31560482 |
Gun shot wound | 45.09 | 11.22 | 26 | 52439 | 1068 | 31643811 |
Arnold-Chiari malformation | 45.04 | 11.22 | 18 | 52447 | 320 | 31644559 |
Diarrhoea | 44.40 | 11.22 | 372 | 52093 | 352037 | 31292842 |
Visceral congestion | 43.31 | 11.22 | 20 | 52445 | 513 | 31644366 |
Maternal drugs affecting foetus | 43.10 | 11.22 | 42 | 52423 | 3861 | 31641018 |
Depressed mood | 43.06 | 11.22 | 92 | 52373 | 17483 | 31627396 |
Nightmare | 42.61 | 11.22 | 74 | 52391 | 12063 | 31632816 |
Tremor neonatal | 42.42 | 11.22 | 18 | 52447 | 375 | 31644504 |
Thrombocytopenia | 42.33 | 11.22 | 110 | 52355 | 142637 | 31502242 |
Ventricular hypoplasia | 41.78 | 11.22 | 12 | 52453 | 71 | 31644808 |
Attention deficit hyperactivity disorder | 40.87 | 11.22 | 33 | 52432 | 2365 | 31642514 |
Anaemia | 40.35 | 11.22 | 199 | 52266 | 213323 | 31431556 |
Right aortic arch | 39.85 | 11.22 | 9 | 52456 | 15 | 31644864 |
Disease progression | 39.74 | 11.22 | 55 | 52410 | 90409 | 31554470 |
Hangover | 39.51 | 11.22 | 23 | 52442 | 962 | 31643917 |
Hyperreflexia | 38.84 | 11.22 | 35 | 52430 | 2914 | 31641965 |
Congenital tricuspid valve atresia | 38.13 | 11.22 | 12 | 52453 | 101 | 31644778 |
Pyrexia | 38.11 | 11.22 | 321 | 52144 | 303519 | 31341360 |
Restlessness | 37.61 | 11.22 | 104 | 52361 | 23257 | 31621622 |
Rash | 37.37 | 11.22 | 189 | 52276 | 201297 | 31443582 |
Mydriasis | 37.28 | 11.22 | 50 | 52415 | 6502 | 31638377 |
Mitral valve stenosis | 37.16 | 11.22 | 15 | 52450 | 274 | 31644605 |
Right ventricular hypertrophy | 36.53 | 11.22 | 24 | 52441 | 1247 | 31643632 |
Amnesia | 36.51 | 11.22 | 103 | 52362 | 23299 | 31621580 |
Akathisia | 36.25 | 11.22 | 52 | 52413 | 7201 | 31637678 |
Toxicity to various agents | 36.23 | 11.22 | 459 | 52006 | 181028 | 31463851 |
Malignant neoplasm progression | 35.73 | 11.22 | 47 | 52418 | 78951 | 31565928 |
Plasma cell myeloma | 35.62 | 11.22 | 25 | 52440 | 56506 | 31588373 |
Ejaculation delayed | 35.61 | 11.22 | 14 | 52451 | 238 | 31644641 |
Feeling of despair | 35.17 | 11.22 | 21 | 52444 | 921 | 31643958 |
Neutropenia | 34.51 | 11.22 | 118 | 52347 | 140246 | 31504633 |
Somnolence neonatal | 34.48 | 11.22 | 8 | 52457 | 16 | 31644863 |
Abnormal behaviour | 34.40 | 11.22 | 102 | 52363 | 23726 | 31621153 |
Abdominal pain | 34.35 | 11.22 | 125 | 52340 | 145827 | 31499052 |
Memory impairment | 33.92 | 11.22 | 139 | 52326 | 37991 | 31606888 |
Bipolar disorder | 33.71 | 11.22 | 36 | 52429 | 3688 | 31641191 |
Atrial fibrillation | 33.47 | 11.22 | 88 | 52377 | 113695 | 31531184 |
Parkinsonism | 32.80 | 11.22 | 51 | 52414 | 7585 | 31637294 |
Congenital scoliosis | 32.66 | 11.22 | 10 | 52455 | 76 | 31644803 |
Hyperthermia | 32.54 | 11.22 | 59 | 52406 | 9945 | 31634934 |
Agoraphobia | 32.49 | 11.22 | 13 | 52452 | 232 | 31644647 |
DiGeorge's syndrome | 32.43 | 11.22 | 6 | 52459 | 0 | 31644879 |
Interruption of aortic arch | 32.43 | 11.22 | 6 | 52459 | 0 | 31644879 |
Oral discharge | 32.41 | 11.22 | 11 | 52454 | 120 | 31644759 |
Hypomania | 32.38 | 11.22 | 28 | 52437 | 2207 | 31642672 |
Congenital aortic anomaly | 32.33 | 11.22 | 10 | 52455 | 79 | 31644800 |
COVID-19 | 32.28 | 11.22 | 26 | 52439 | 54795 | 31590084 |
Choanal atresia | 32.07 | 11.22 | 7 | 52458 | 9 | 31644870 |
Infection | 31.95 | 11.22 | 54 | 52411 | 81877 | 31563002 |
Libido decreased | 31.82 | 11.22 | 38 | 52427 | 4398 | 31640481 |
Anencephaly | 31.77 | 11.22 | 11 | 52454 | 128 | 31644751 |
Hypospadias | 31.57 | 11.22 | 32 | 52433 | 3084 | 31641795 |
Congenital pulmonary artery anomaly | 30.87 | 11.22 | 7 | 52458 | 12 | 31644867 |
Homicidal ideation | 30.72 | 11.22 | 29 | 52436 | 2562 | 31642317 |
Cough | 30.71 | 11.22 | 117 | 52348 | 134697 | 31510182 |
Pancytopenia | 30.12 | 11.22 | 62 | 52403 | 87254 | 31557625 |
Renal impairment | 30.05 | 11.22 | 61 | 52404 | 86288 | 31558591 |
Vertigo | 29.77 | 11.22 | 95 | 52370 | 22990 | 31621889 |
Product use issue | 29.74 | 11.22 | 30 | 52435 | 56729 | 31588150 |
Paraesthesia | 29.51 | 11.22 | 176 | 52289 | 55895 | 31588984 |
Dextrocardia | 29.31 | 11.22 | 10 | 52455 | 111 | 31644768 |
Muscle rigidity | 29.23 | 11.22 | 56 | 52409 | 9841 | 31635038 |
Congenital coronary artery malformation | 28.98 | 11.22 | 8 | 52457 | 40 | 31644839 |
Verbal abuse | 28.88 | 11.22 | 11 | 52454 | 171 | 31644708 |
Epistaxis | 28.58 | 11.22 | 28 | 52437 | 53679 | 31591200 |
Drug dependence | 28.28 | 11.22 | 92 | 52373 | 22487 | 31622392 |
General physical health deterioration | 28.12 | 11.22 | 95 | 52370 | 113340 | 31531539 |
Disorientation | 28.07 | 11.22 | 113 | 52352 | 30631 | 31614248 |
Thinking abnormal | 27.92 | 11.22 | 40 | 52425 | 5533 | 31639346 |
Congenital genitourinary abnormality | 27.62 | 11.22 | 8 | 52457 | 49 | 31644830 |
Cytomegalovirus infection | 27.61 | 11.22 | 4 | 52461 | 24703 | 31620176 |
Physical assault | 27.35 | 11.22 | 19 | 52446 | 1083 | 31643796 |
Emotional distress | 27.28 | 11.22 | 68 | 52397 | 14288 | 31630591 |
Intentional product use issue | 27.11 | 11.22 | 25 | 52440 | 49322 | 31595557 |
Congenital mitral valve stenosis | 27.03 | 11.22 | 5 | 52460 | 0 | 31644879 |
Ebstein's anomaly | 27.03 | 11.22 | 5 | 52460 | 0 | 31644879 |
Developmental hip dysplasia | 26.83 | 11.22 | 12 | 52453 | 285 | 31644594 |
Hyper IgE syndrome | 26.83 | 11.22 | 8 | 52457 | 55 | 31644824 |
Paranoia | 26.72 | 11.22 | 56 | 52409 | 10499 | 31634380 |
Altered state of consciousness | 26.57 | 11.22 | 86 | 52379 | 20965 | 31623914 |
Multiple cardiac defects | 26.11 | 11.22 | 8 | 52457 | 61 | 31644818 |
Selective eating disorder | 25.84 | 11.22 | 22 | 52443 | 1698 | 31643181 |
Drug abuser | 25.82 | 11.22 | 32 | 52433 | 3848 | 31641031 |
Cleft lip | 25.76 | 11.22 | 12 | 52453 | 314 | 31644565 |
Pulmonary artery stenosis | 25.76 | 11.22 | 11 | 52454 | 233 | 31644646 |
Treatment failure | 25.75 | 11.22 | 18 | 52447 | 40774 | 31604105 |
Ejaculation failure | 25.74 | 11.22 | 16 | 52449 | 755 | 31644124 |
Tearfulness | 25.63 | 11.22 | 23 | 52442 | 1904 | 31642975 |
Vascular stenosis | 25.27 | 11.22 | 10 | 52455 | 173 | 31644706 |
C-reactive protein increased | 25.16 | 11.22 | 26 | 52439 | 48624 | 31596255 |
Blepharospasm | 25.05 | 11.22 | 18 | 52447 | 1083 | 31643796 |
Pulmonary valve incompetence | 25.00 | 11.22 | 16 | 52449 | 795 | 31644084 |
Autism spectrum disorder | 24.95 | 11.22 | 24 | 52441 | 2171 | 31642708 |
Product use in unapproved indication | 24.61 | 11.22 | 83 | 52382 | 99088 | 31545791 |
Bronchopulmonary dysplasia | 24.57 | 11.22 | 14 | 52451 | 562 | 31644317 |
Congenital hand malformation | 24.26 | 11.22 | 14 | 52451 | 576 | 31644303 |
Myoclonus | 24.24 | 11.22 | 64 | 52401 | 13926 | 31630953 |
Depressed level of consciousness | 24.18 | 11.22 | 127 | 52338 | 38474 | 31606405 |
Joint swelling | 23.94 | 11.22 | 32 | 52433 | 53399 | 31591480 |
Congenital pulmonary hypertension | 23.88 | 11.22 | 7 | 52458 | 45 | 31644834 |
Emotional disorder | 23.87 | 11.22 | 36 | 52429 | 5213 | 31639666 |
Septic shock | 23.65 | 11.22 | 46 | 52419 | 66112 | 31578767 |
Neural tube defect | 23.62 | 11.22 | 7 | 52458 | 47 | 31644832 |
Congenital tracheomalacia | 23.10 | 11.22 | 5 | 52460 | 6 | 31644873 |
Platelet count decreased | 22.54 | 11.22 | 100 | 52365 | 110335 | 31534544 |
Hepatic enzyme increased | 22.46 | 11.22 | 16 | 52449 | 35892 | 31608987 |
Truncus arteriosus persistent | 22.43 | 11.22 | 6 | 52459 | 26 | 31644853 |
Aortic valve incompetence | 22.41 | 11.22 | 36 | 52429 | 5505 | 31639374 |
Gastroschisis | 22.17 | 11.22 | 8 | 52457 | 106 | 31644773 |
Rheumatoid arthritis | 22.07 | 11.22 | 28 | 52437 | 47781 | 31597098 |
Logorrhoea | 22.02 | 11.22 | 23 | 52442 | 2296 | 31642583 |
Neonatal asphyxia | 22.02 | 11.22 | 11 | 52454 | 337 | 31644542 |
Cardiomegaly | 22.02 | 11.22 | 63 | 52402 | 14362 | 31630517 |
Mood altered | 21.97 | 11.22 | 45 | 52420 | 8301 | 31636578 |
Prostate cancer | 21.93 | 11.22 | 18 | 52447 | 37583 | 31607296 |
Spina bifida | 21.84 | 11.22 | 11 | 52454 | 343 | 31644536 |
Haemoglobin decreased | 21.82 | 11.22 | 104 | 52361 | 112571 | 31532308 |
Congenital hydronephrosis | 21.70 | 11.22 | 14 | 52451 | 705 | 31644174 |
Noonan syndrome | 21.62 | 11.22 | 4 | 52461 | 0 | 31644879 |
Mitral valve atresia | 21.62 | 11.22 | 4 | 52461 | 0 | 31644879 |
Idiosyncratic alcohol intoxication | 21.62 | 11.22 | 4 | 52461 | 0 | 31644879 |
Abdominal transposition | 21.62 | 11.22 | 4 | 52461 | 0 | 31644879 |
Porencephaly | 21.62 | 11.22 | 4 | 52461 | 0 | 31644879 |
Reversible cerebral vasoconstriction syndrome | 21.61 | 11.22 | 11 | 52454 | 351 | 31644528 |
Congenital diaphragmatic hernia | 21.49 | 11.22 | 10 | 52455 | 261 | 31644618 |
Psychotic disorder | 21.20 | 11.22 | 83 | 52382 | 22210 | 31622669 |
Erythema | 20.84 | 11.22 | 66 | 52399 | 80339 | 31564540 |
Agitation neonatal | 20.82 | 11.22 | 16 | 52449 | 1067 | 31643812 |
Sleep apnoea syndrome | 20.77 | 11.22 | 73 | 52392 | 18552 | 31626327 |
Chemical submission | 20.68 | 11.22 | 6 | 52459 | 37 | 31644842 |
Hallucination, auditory | 20.67 | 11.22 | 50 | 52415 | 10310 | 31634569 |
Infantile apnoea | 20.63 | 11.22 | 15 | 52450 | 919 | 31643960 |
Affect lability | 20.57 | 11.22 | 27 | 52438 | 3438 | 31641441 |
Self esteem decreased | 20.55 | 11.22 | 12 | 52453 | 505 | 31644374 |
Blood creatine phosphokinase increased | 20.34 | 11.22 | 129 | 52336 | 41845 | 31603034 |
Premature baby | 20.32 | 11.22 | 71 | 52394 | 17995 | 31626884 |
Peripheral swelling | 20.31 | 11.22 | 52 | 52413 | 67813 | 31577066 |
Flat affect | 20.29 | 11.22 | 14 | 52451 | 789 | 31644090 |
Pneumocystis jirovecii pneumonia | 20.29 | 11.22 | 3 | 52462 | 18248 | 31626631 |
Wolff-Parkinson-White syndrome | 20.23 | 11.22 | 9 | 52456 | 211 | 31644668 |
Ventricular hypertrophy | 20.20 | 11.22 | 30 | 52435 | 4286 | 31640593 |
Resting tremor | 20.18 | 11.22 | 13 | 52452 | 653 | 31644226 |
Dystonia | 20.03 | 11.22 | 49 | 52416 | 10176 | 31634703 |
Ascites | 20.01 | 11.22 | 23 | 52442 | 40990 | 31603889 |
Somatic dysfunction | 19.88 | 11.22 | 5 | 52460 | 16 | 31644863 |
Obsessive-compulsive disorder | 19.86 | 11.22 | 32 | 52433 | 4905 | 31639974 |
Respiratory acidosis | 19.83 | 11.22 | 31 | 52434 | 4631 | 31640248 |
Bradykinesia | 19.81 | 11.22 | 27 | 52438 | 3565 | 31641314 |
Congenital hydrocephalus | 19.73 | 11.22 | 7 | 52458 | 88 | 31644791 |
Seizure | 19.72 | 11.22 | 252 | 52213 | 99516 | 31545363 |
Decreased interest | 19.56 | 11.22 | 21 | 52444 | 2164 | 31642715 |
Congenital flat feet | 19.39 | 11.22 | 4 | 52461 | 3 | 31644876 |
Cardiac failure | 19.29 | 11.22 | 75 | 52390 | 85878 | 31559001 |
Tension | 19.28 | 11.22 | 20 | 52445 | 1981 | 31642898 |
Delirium | 19.27 | 11.22 | 126 | 52339 | 41295 | 31603584 |
Derealisation | 19.18 | 11.22 | 12 | 52453 | 573 | 31644306 |
Cerebrovascular stenosis | 18.98 | 11.22 | 7 | 52458 | 99 | 31644780 |
Clumsiness | 18.97 | 11.22 | 18 | 52447 | 1601 | 31643278 |
Infantile back arching | 18.86 | 11.22 | 4 | 52461 | 4 | 31644875 |
Right ventricle outflow tract obstruction | 18.86 | 11.22 | 4 | 52461 | 4 | 31644875 |
Asphyxia | 18.81 | 11.22 | 34 | 52431 | 5717 | 31639162 |
Transient tachypnoea of the newborn | 18.71 | 11.22 | 8 | 52457 | 170 | 31644709 |
Scaphocephaly | 18.63 | 11.22 | 5 | 52460 | 22 | 31644857 |
Sedation complication | 18.59 | 11.22 | 17 | 52448 | 1442 | 31643437 |
Euphoric mood | 18.59 | 11.22 | 31 | 52434 | 4889 | 31639990 |
Tonic convulsion | 18.52 | 11.22 | 15 | 52450 | 1080 | 31643799 |
Psychiatric symptom | 18.43 | 11.22 | 25 | 52440 | 3286 | 31641593 |
Hospitalisation | 18.35 | 11.22 | 34 | 52431 | 49773 | 31595106 |
Dysmorphism | 18.33 | 11.22 | 24 | 52441 | 3048 | 31641831 |
Mucosal inflammation | 18.26 | 11.22 | 18 | 52447 | 34409 | 31610470 |
Crying | 18.19 | 11.22 | 33 | 52432 | 5564 | 31639315 |
Oedema peripheral | 18.14 | 11.22 | 107 | 52358 | 109732 | 31535147 |
Obsessive thoughts | 18.14 | 11.22 | 12 | 52453 | 631 | 31644248 |
Dissociation | 18.13 | 11.22 | 16 | 52449 | 1296 | 31643583 |
Caesarean section | 18.03 | 11.22 | 19 | 52446 | 1917 | 31642962 |
Personality disorder | 18.02 | 11.22 | 15 | 52450 | 1122 | 31643757 |
Intention tremor | 17.98 | 11.22 | 10 | 52455 | 383 | 31644496 |
Aortic stenosis | 17.70 | 11.22 | 27 | 52438 | 3949 | 31640930 |
Neutrophil count decreased | 17.69 | 11.22 | 31 | 52434 | 46363 | 31598516 |
Ejaculation disorder | 17.67 | 11.22 | 14 | 52451 | 976 | 31643903 |
Dyskinesia | 17.63 | 11.22 | 75 | 52390 | 20835 | 31624044 |
Abulia | 17.54 | 11.22 | 11 | 52454 | 527 | 31644352 |
Infusion related reaction | 17.53 | 11.22 | 33 | 52432 | 48022 | 31596857 |
Renal failure | 17.40 | 11.22 | 126 | 52339 | 123204 | 31521675 |
Gastrointestinal haemorrhage | 17.29 | 11.22 | 74 | 52391 | 82475 | 31562404 |
Ammonia abnormal | 17.24 | 11.22 | 6 | 52459 | 71 | 31644808 |
Renal dysplasia | 17.19 | 11.22 | 8 | 52457 | 209 | 31644670 |
Tricuspid valve disease | 17.19 | 11.22 | 8 | 52457 | 209 | 31644670 |
Abnormal dreams | 17.17 | 11.22 | 37 | 52428 | 7071 | 31637808 |
Chordee | 17.16 | 11.22 | 6 | 52459 | 72 | 31644807 |
Maternal exposure during pregnancy | 17.14 | 11.22 | 29 | 52436 | 4627 | 31640252 |
Panic disorder | 17.08 | 11.22 | 15 | 52450 | 1207 | 31643672 |
Alcohol interaction | 16.97 | 11.22 | 22 | 52443 | 2767 | 31642112 |
Speech disorder | 16.82 | 11.22 | 82 | 52383 | 24119 | 31620760 |
Hypotension | 16.82 | 11.22 | 238 | 52227 | 204380 | 31440499 |
Leukopenia | 16.78 | 11.22 | 45 | 52420 | 57783 | 31587096 |
White blood cell count decreased | 16.72 | 11.22 | 81 | 52384 | 87317 | 31557562 |
Hyperkinesia | 16.62 | 11.22 | 17 | 52448 | 1656 | 31643223 |
Pleurothotonus | 16.57 | 11.22 | 14 | 52451 | 1069 | 31643810 |
Judgement impaired | 16.56 | 11.22 | 11 | 52454 | 582 | 31644297 |
Contraindicated product administered | 16.56 | 11.22 | 6 | 52459 | 19766 | 31625113 |
Pulmonary hypoplasia | 16.55 | 11.22 | 10 | 52455 | 448 | 31644431 |
Type 2 diabetes mellitus | 16.53 | 11.22 | 58 | 52407 | 14726 | 31630153 |
Opisthotonus | 16.47 | 11.22 | 10 | 52455 | 452 | 31644427 |
Hypersensitivity | 16.46 | 11.22 | 43 | 52422 | 55700 | 31589179 |
Hypertonia | 16.35 | 11.22 | 26 | 52439 | 3942 | 31640937 |
Major depression | 16.34 | 11.22 | 27 | 52438 | 4226 | 31640653 |
Loss of libido | 16.34 | 11.22 | 20 | 52445 | 2375 | 31642504 |
Cyclothymic disorder | 16.32 | 11.22 | 6 | 52459 | 84 | 31644795 |
Neurosis | 16.32 | 11.22 | 7 | 52458 | 150 | 31644729 |
Vesicoureteric reflux | 16.32 | 11.22 | 7 | 52458 | 150 | 31644729 |
Multiple organ dysfunction syndrome | 16.29 | 11.22 | 58 | 52407 | 68145 | 31576734 |
Jaundice neonatal | 16.28 | 11.22 | 15 | 52450 | 1285 | 31643594 |
Congenital pulmonary valve disorder | 16.22 | 11.22 | 3 | 52462 | 0 | 31644879 |
Congenital Eustachian tube anomaly | 16.22 | 11.22 | 3 | 52462 | 0 | 31644879 |
Congenital renal disorder | 16.07 | 11.22 | 6 | 52459 | 88 | 31644791 |
Delusion | 16.04 | 11.22 | 50 | 52415 | 11947 | 31632932 |
Inadequate analgesia | 16.01 | 11.22 | 21 | 52444 | 2672 | 31642207 |
Device breakage | 15.91 | 11.22 | 18 | 52447 | 1966 | 31642913 |
Subgaleal haematoma | 15.89 | 11.22 | 5 | 52460 | 42 | 31644837 |
Cryptorchism | 15.89 | 11.22 | 18 | 52447 | 1969 | 31642910 |
Lower respiratory tract infection | 15.87 | 11.22 | 14 | 52451 | 28223 | 31616656 |
Neuropathy peripheral | 15.73 | 11.22 | 68 | 52397 | 75581 | 31569298 |
Neoplasm progression | 15.59 | 11.22 | 7 | 52458 | 20265 | 31624614 |
Arthralgia | 15.50 | 11.22 | 168 | 52297 | 151256 | 31493623 |
Psoriasis | 15.41 | 11.22 | 34 | 52431 | 46685 | 31598194 |
Legal problem | 15.40 | 11.22 | 7 | 52458 | 173 | 31644706 |
Cerebral palsy | 15.37 | 11.22 | 6 | 52459 | 100 | 31644779 |
Exomphalos | 15.29 | 11.22 | 7 | 52458 | 176 | 31644703 |
Infertility male | 15.18 | 11.22 | 7 | 52458 | 179 | 31644700 |
Chronic kidney disease | 14.82 | 11.22 | 25 | 52440 | 37950 | 31606929 |
Ankyloglossia congenital | 14.81 | 11.22 | 8 | 52457 | 289 | 31644590 |
Congenital mitral valve incompetence | 14.80 | 11.22 | 6 | 52459 | 111 | 31644768 |
Mitral valve incompetence | 14.79 | 11.22 | 54 | 52411 | 13979 | 31630900 |
Thrombosis | 14.78 | 11.22 | 33 | 52432 | 45118 | 31599761 |
Haemoptysis | 14.70 | 11.22 | 19 | 52446 | 32170 | 31612709 |
Impulse-control disorder | 14.59 | 11.22 | 14 | 52451 | 1262 | 31643617 |
Feeling jittery | 14.54 | 11.22 | 24 | 52441 | 3753 | 31641126 |
Phimosis | 14.53 | 11.22 | 11 | 52454 | 717 | 31644162 |
Vasoplegia syndrome | 14.52 | 11.22 | 16 | 52449 | 1697 | 31643182 |
Colitis | 14.47 | 11.22 | 21 | 52444 | 33866 | 31611013 |
Feeling abnormal | 14.39 | 11.22 | 151 | 52314 | 56851 | 31588028 |
Hallucination, visual | 14.37 | 11.22 | 58 | 52407 | 15736 | 31629143 |
Brachycephaly | 14.30 | 11.22 | 5 | 52460 | 60 | 31644819 |
Abdominal distension | 14.28 | 11.22 | 40 | 52425 | 50644 | 31594235 |
Mitral valve prolapse | 14.27 | 11.22 | 10 | 52455 | 578 | 31644301 |
Feeling guilty | 14.23 | 11.22 | 8 | 52457 | 313 | 31644566 |
Oculoauriculovertebral dysplasia | 14.14 | 11.22 | 3 | 52462 | 3 | 31644876 |
Cytokine release syndrome | 14.02 | 11.22 | 5 | 52460 | 16637 | 31628242 |
Pyloric stenosis | 14.01 | 11.22 | 11 | 52454 | 757 | 31644122 |
Drug intolerance | 13.98 | 11.22 | 42 | 52423 | 51991 | 31592888 |
Anaphylactic reaction | 13.96 | 11.22 | 17 | 52448 | 29536 | 31615343 |
Incoherent | 13.76 | 11.22 | 25 | 52440 | 4219 | 31640660 |
Product complaint | 13.62 | 11.22 | 29 | 52436 | 5495 | 31639384 |
Poisoning | 13.61 | 11.22 | 43 | 52422 | 10348 | 31634531 |
Sexually transmitted disease | 13.61 | 11.22 | 4 | 52461 | 26 | 31644853 |
Pruritus | 13.56 | 11.22 | 137 | 52328 | 125030 | 31519849 |
Tardive dyskinesia | 13.50 | 11.22 | 29 | 52436 | 5530 | 31639349 |
Cytogenetic abnormality | 13.33 | 11.22 | 11 | 52454 | 813 | 31644066 |
Congenital tricuspid valve incompetence | 13.32 | 11.22 | 6 | 52459 | 145 | 31644734 |
Plasmodium vivax infection | 13.28 | 11.22 | 3 | 52462 | 5 | 31644874 |
Apnoea | 13.27 | 11.22 | 31 | 52434 | 6251 | 31638628 |
Anomalous pulmonary venous connection | 13.23 | 11.22 | 5 | 52460 | 76 | 31644803 |
Asplenia | 13.05 | 11.22 | 5 | 52460 | 79 | 31644800 |
Pulmonary aplasia | 12.93 | 11.22 | 3 | 52462 | 6 | 31644873 |
Drug screen positive | 12.89 | 11.22 | 23 | 52442 | 3829 | 31641050 |
Basal cell carcinoma | 12.89 | 11.22 | 7 | 52458 | 18172 | 31626707 |
Administration related reaction | 12.88 | 11.22 | 5 | 52460 | 82 | 31644797 |
Mitral valve disease | 12.85 | 11.22 | 13 | 52452 | 1250 | 31643629 |
Personality change | 12.79 | 11.22 | 26 | 52439 | 4769 | 31640110 |
Therapeutic response decreased | 12.79 | 11.22 | 15 | 52450 | 26494 | 31618385 |
Jealous delusion | 12.76 | 11.22 | 7 | 52458 | 261 | 31644618 |
Hallucination | 12.70 | 11.22 | 125 | 52340 | 46285 | 31598594 |
Periventricular leukomalacia | 12.67 | 11.22 | 4 | 52461 | 34 | 31644845 |
Hepatotoxicity | 12.66 | 11.22 | 8 | 52457 | 19118 | 31625761 |
Hydrocele | 12.63 | 11.22 | 16 | 52449 | 1967 | 31642912 |
Urinary tract infection | 12.62 | 11.22 | 75 | 52390 | 76794 | 31568085 |
Otitis media chronic | 12.61 | 11.22 | 5 | 52460 | 87 | 31644792 |
Hyperventilation | 12.60 | 11.22 | 18 | 52447 | 2483 | 31642396 |
Rebound effect | 12.53 | 11.22 | 18 | 52447 | 2495 | 31642384 |
Aorta hypoplasia | 12.51 | 11.22 | 5 | 52460 | 89 | 31644790 |
Eating disorder | 12.48 | 11.22 | 34 | 52431 | 7535 | 31637344 |
Palmar-plantar erythrodysaesthesia syndrome | 12.46 | 11.22 | 5 | 52460 | 15478 | 31629401 |
Limb asymmetry | 12.40 | 11.22 | 5 | 52460 | 91 | 31644788 |
Failure to thrive | 12.37 | 11.22 | 35 | 52430 | 7927 | 31636952 |
Weight gain poor | 12.37 | 11.22 | 11 | 52454 | 900 | 31643979 |
Hyponatraemia | 12.36 | 11.22 | 181 | 52284 | 73618 | 31571261 |
Eyelid ptosis congenital | 12.35 | 11.22 | 5 | 52460 | 92 | 31644787 |
Renal salt-wasting syndrome | 12.35 | 11.22 | 7 | 52458 | 278 | 31644601 |
Thought insertion | 12.33 | 11.22 | 3 | 52462 | 8 | 31644871 |
Bone marrow failure | 12.31 | 11.22 | 17 | 52448 | 27991 | 31616888 |
Hypocalcaemia | 12.23 | 11.22 | 11 | 52454 | 21967 | 31622912 |
Hepatocellular injury | 12.22 | 11.22 | 69 | 52396 | 21475 | 31623404 |
Genital paraesthesia | 12.19 | 11.22 | 4 | 52461 | 39 | 31644840 |
Acute myeloid leukaemia | 12.10 | 11.22 | 8 | 52457 | 18664 | 31626215 |
Depersonalisation/derealisation disorder | 12.02 | 11.22 | 9 | 52456 | 577 | 31644302 |
Device related infection | 11.96 | 11.22 | 6 | 52459 | 16293 | 31628586 |
Tinnitus | 11.93 | 11.22 | 56 | 52409 | 16219 | 31628660 |
Colitis ulcerative | 11.92 | 11.22 | 8 | 52457 | 18521 | 31626358 |
Hypertonia neonatal | 11.92 | 11.22 | 8 | 52457 | 431 | 31644448 |
Loss of consciousness | 11.90 | 11.22 | 187 | 52278 | 77168 | 31567711 |
Patient uncooperative | 11.90 | 11.22 | 8 | 52457 | 432 | 31644447 |
Ventricular tachycardia | 11.88 | 11.22 | 13 | 52452 | 23688 | 31621191 |
Duodenal atresia | 11.83 | 11.22 | 3 | 52462 | 10 | 31644869 |
Persistent depressive disorder | 11.79 | 11.22 | 7 | 52458 | 304 | 31644575 |
Feeling of relaxation | 11.76 | 11.22 | 4 | 52461 | 44 | 31644835 |
Exhibitionism | 11.76 | 11.22 | 4 | 52461 | 44 | 31644835 |
Neutropenic sepsis | 11.73 | 11.22 | 3 | 52462 | 12376 | 31632503 |
Epilepsy | 11.68 | 11.22 | 67 | 52398 | 20974 | 31623905 |
Swelling | 11.66 | 11.22 | 28 | 52437 | 37330 | 31607549 |
Suspiciousness | 11.66 | 11.22 | 7 | 52458 | 310 | 31644569 |
Herpes zoster | 11.64 | 11.22 | 22 | 52443 | 31971 | 31612908 |
Divorced | 11.61 | 11.22 | 3 | 52462 | 11 | 31644868 |
Blood creatinine increased | 11.61 | 11.22 | 93 | 52372 | 88985 | 31555894 |
Product administration error | 11.57 | 11.22 | 53 | 52412 | 15194 | 31629685 |
Microcephaly | 11.54 | 11.22 | 10 | 52455 | 790 | 31644089 |
Neonatal disorder | 11.48 | 11.22 | 10 | 52455 | 796 | 31644083 |
Pain in extremity | 11.45 | 11.22 | 130 | 52335 | 116073 | 31528806 |
Dehydration | 11.45 | 11.22 | 134 | 52331 | 118977 | 31525902 |
Decerebrate posture | 11.44 | 11.22 | 4 | 52461 | 48 | 31644831 |
Inflammation | 11.42 | 11.22 | 15 | 52450 | 25226 | 31619653 |
Haematochezia | 11.35 | 11.22 | 32 | 52433 | 40432 | 31604447 |
Bundle branch block | 11.33 | 11.22 | 10 | 52455 | 810 | 31644069 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 837.14 | 10.05 | 635 | 117149 | 41479 | 70769181 |
Drug withdrawal syndrome | 755.47 | 10.05 | 540 | 117244 | 32175 | 70778485 |
Suicidal ideation | 594.59 | 10.05 | 653 | 117131 | 68943 | 70741717 |
Anxiety | 524.02 | 10.05 | 1140 | 116644 | 219190 | 70591470 |
Suicide attempt | 509.66 | 10.05 | 644 | 117140 | 78866 | 70731794 |
Drug abuse | 500.89 | 10.05 | 886 | 116898 | 146370 | 70664290 |
Sopor | 465.04 | 10.05 | 398 | 117386 | 30869 | 70779791 |
Depression | 449.79 | 10.05 | 1009 | 116775 | 197965 | 70612695 |
Agitation | 333.07 | 10.05 | 574 | 117210 | 92801 | 70717859 |
Tremor | 323.65 | 10.05 | 764 | 117020 | 154860 | 70655800 |
Intentional self-injury | 294.76 | 10.05 | 311 | 117473 | 31339 | 70779321 |
Completed suicide | 287.77 | 10.05 | 930 | 116854 | 226205 | 70584455 |
Somnolence | 268.77 | 10.05 | 878 | 116906 | 214728 | 70595932 |
Irritability | 256.56 | 10.05 | 317 | 117467 | 37908 | 70772752 |
Mydriasis | 247.05 | 10.05 | 209 | 117575 | 15944 | 70794716 |
Mania | 231.96 | 10.05 | 207 | 117577 | 16967 | 70793693 |
Aggression | 230.78 | 10.05 | 340 | 117444 | 48106 | 70762554 |
Rheumatoid arthritis | 209.11 | 10.05 | 112 | 117672 | 291693 | 70518967 |
Neuroleptic malignant syndrome | 208.14 | 10.05 | 236 | 117548 | 25771 | 70784889 |
Nightmare | 201.48 | 10.05 | 215 | 117569 | 21941 | 70788719 |
Drug interaction | 199.60 | 10.05 | 1197 | 116587 | 380244 | 70430416 |
Panic attack | 196.49 | 10.05 | 212 | 117572 | 21907 | 70788753 |
Confusional state | 195.00 | 10.05 | 961 | 116823 | 283437 | 70527223 |
Disturbance in attention | 192.82 | 10.05 | 293 | 117491 | 42601 | 70768059 |
Off label use | 192.32 | 10.05 | 615 | 117169 | 742445 | 70068215 |
Poisoning deliberate | 179.41 | 10.05 | 179 | 117605 | 16881 | 70793779 |
Depersonalisation/derealisation disorder | 165.33 | 10.05 | 73 | 117711 | 1675 | 70808985 |
Contraindicated product administered | 162.92 | 10.05 | 17 | 117767 | 134595 | 70676065 |
Activation syndrome | 161.55 | 10.05 | 45 | 117739 | 233 | 70810427 |
Derealisation | 157.82 | 10.05 | 68 | 117716 | 1468 | 70809192 |
Disorientation | 157.45 | 10.05 | 317 | 117467 | 57606 | 70753054 |
Hyponatraemia | 156.37 | 10.05 | 602 | 117182 | 159485 | 70651175 |
Inappropriate antidiuretic hormone secretion | 151.31 | 10.05 | 190 | 117594 | 23086 | 70787574 |
Mood swings | 146.42 | 10.05 | 166 | 117618 | 18120 | 70792540 |
Toxicity to various agents | 146.16 | 10.05 | 1110 | 116674 | 381062 | 70429598 |
Insomnia | 144.92 | 10.05 | 730 | 117054 | 217076 | 70593584 |
Febrile neutropenia | 143.99 | 10.05 | 80 | 117704 | 204238 | 70606422 |
Hyperhidrosis | 142.84 | 10.05 | 512 | 117272 | 131074 | 70679586 |
Extrapyramidal disorder | 142.30 | 10.05 | 174 | 117610 | 20576 | 70790084 |
Withdrawal syndrome | 141.16 | 10.05 | 190 | 117594 | 24714 | 70785946 |
Dissociation | 140.95 | 10.05 | 81 | 117703 | 3295 | 70807365 |
Feeling of despair | 139.25 | 10.05 | 74 | 117710 | 2577 | 70808083 |
Bradyphrenia | 138.52 | 10.05 | 122 | 117662 | 9824 | 70800836 |
Joint swelling | 138.24 | 10.05 | 130 | 117654 | 253081 | 70557579 |
Anger | 136.98 | 10.05 | 151 | 117633 | 15981 | 70794679 |
Overdose | 132.56 | 10.05 | 596 | 117188 | 169149 | 70641511 |
Intentional overdose | 130.75 | 10.05 | 410 | 117374 | 98025 | 70712635 |
Restlessness | 128.42 | 10.05 | 242 | 117542 | 41886 | 70768774 |
Synovitis | 125.71 | 10.05 | 30 | 117754 | 129198 | 70681462 |
Drug intolerance | 124.20 | 10.05 | 115 | 117669 | 225572 | 70585088 |
Impulsive behaviour | 122.85 | 10.05 | 69 | 117715 | 2685 | 70807975 |
Dyskinesia | 116.67 | 10.05 | 229 | 117555 | 40845 | 70769815 |
Alopecia | 116.66 | 10.05 | 95 | 117689 | 198395 | 70612265 |
Drug ineffective | 115.97 | 10.05 | 1002 | 116782 | 938750 | 69871910 |
Cogwheel rigidity | 115.41 | 10.05 | 68 | 117716 | 2900 | 70807760 |
Homicide | 114.35 | 10.05 | 50 | 117734 | 1120 | 70809540 |
Coma | 112.41 | 10.05 | 372 | 117412 | 91472 | 70719188 |
Infusion related reaction | 105.93 | 10.05 | 103 | 117681 | 197431 | 70613229 |
Rash | 101.76 | 10.05 | 469 | 117315 | 510093 | 70300567 |
Gastric pH decreased | 101.55 | 10.05 | 41 | 117743 | 747 | 70809913 |
Systemic lupus erythematosus | 100.41 | 10.05 | 23 | 117761 | 101879 | 70708781 |
Treatment failure | 99.29 | 10.05 | 58 | 117726 | 144084 | 70666576 |
Hallucinations, mixed | 98.68 | 10.05 | 83 | 117701 | 6279 | 70804381 |
Glossodynia | 94.80 | 10.05 | 15 | 117769 | 86472 | 70724188 |
Emotional disorder | 94.10 | 10.05 | 113 | 117671 | 13113 | 70797547 |
Pericarditis | 92.15 | 10.05 | 15 | 117769 | 84690 | 70725970 |
Delirium | 91.99 | 10.05 | 303 | 117481 | 74311 | 70736349 |
Memory impairment | 90.89 | 10.05 | 349 | 117435 | 92292 | 70718368 |
Myoglobin urine present | 90.55 | 10.05 | 37 | 117747 | 696 | 70809964 |
Hyperreflexia | 89.37 | 10.05 | 84 | 117700 | 7358 | 70803302 |
Akathisia | 87.41 | 10.05 | 105 | 117679 | 12188 | 70798472 |
Hallucination, auditory | 86.34 | 10.05 | 128 | 117656 | 18200 | 70792460 |
Agoraphobia | 86.29 | 10.05 | 33 | 117751 | 517 | 70810143 |
Pneumonia | 85.76 | 10.05 | 609 | 117175 | 595623 | 70215037 |
Muscle rigidity | 84.64 | 10.05 | 128 | 117656 | 18522 | 70792138 |
Flat affect | 82.59 | 10.05 | 47 | 117737 | 1876 | 70808784 |
Swelling | 81.09 | 10.05 | 117 | 117667 | 188422 | 70622238 |
Myoclonus | 81.06 | 10.05 | 152 | 117632 | 26203 | 70784457 |
Nervousness | 80.62 | 10.05 | 167 | 117617 | 30953 | 70779707 |
Drug dependence | 80.46 | 10.05 | 186 | 117598 | 37135 | 70773525 |
Sepsis | 78.24 | 10.05 | 182 | 117602 | 244363 | 70566297 |
Altered state of consciousness | 78.22 | 10.05 | 192 | 117592 | 39830 | 70770830 |
Vertigo | 77.76 | 10.05 | 255 | 117529 | 62388 | 70748272 |
Cough | 77.21 | 10.05 | 279 | 117505 | 325098 | 70485562 |
Product use issue | 75.10 | 10.05 | 114 | 117670 | 179823 | 70630837 |
Peripheral swelling | 73.34 | 10.05 | 179 | 117605 | 236384 | 70574276 |
Helicobacter infection | 72.87 | 10.05 | 5 | 117779 | 55651 | 70755009 |
Bronchial neoplasm | 72.68 | 10.05 | 28 | 117756 | 448 | 70810212 |
Homicidal ideation | 72.43 | 10.05 | 53 | 117731 | 3270 | 70807390 |
Paraesthesia | 69.74 | 10.05 | 447 | 117337 | 145090 | 70665570 |
Hypersensitivity | 69.59 | 10.05 | 176 | 117608 | 229636 | 70581024 |
Malignant neoplasm progression | 69.36 | 10.05 | 60 | 117724 | 121679 | 70688981 |
Parkinsonism | 69.29 | 10.05 | 105 | 117679 | 15220 | 70795440 |
Libido increased | 67.93 | 10.05 | 41 | 117743 | 1828 | 70808832 |
Depressed level of consciousness | 66.69 | 10.05 | 305 | 117479 | 87126 | 70723534 |
Abnormal behaviour | 66.23 | 10.05 | 165 | 117619 | 34544 | 70776116 |
Crying | 66.12 | 10.05 | 123 | 117661 | 21076 | 70789584 |
Feeling jittery | 65.31 | 10.05 | 88 | 117696 | 11455 | 70799205 |
Hepatic enzyme increased | 64.03 | 10.05 | 101 | 117683 | 156889 | 70653771 |
Nasal turbinate hypertrophy | 62.61 | 10.05 | 27 | 117757 | 584 | 70810076 |
Depressed mood | 62.32 | 10.05 | 187 | 117597 | 43633 | 70767027 |
Dystonia | 62.29 | 10.05 | 115 | 117669 | 19591 | 70791069 |
Intentional product use issue | 61.69 | 10.05 | 65 | 117719 | 120077 | 70690583 |
Therapeutic product effect decreased | 61.24 | 10.05 | 89 | 117695 | 142929 | 70667731 |
Tearfulness | 60.93 | 10.05 | 57 | 117727 | 4963 | 70805697 |
Speech disorder | 60.20 | 10.05 | 203 | 117581 | 50377 | 70760283 |
Blister | 59.17 | 10.05 | 48 | 117736 | 100478 | 70710182 |
Clonus | 59.06 | 10.05 | 62 | 117722 | 6206 | 70804454 |
Hypomania | 58.89 | 10.05 | 61 | 117723 | 6011 | 70804649 |
Libido decreased | 58.09 | 10.05 | 55 | 117729 | 4861 | 70805799 |
Endometrial ablation | 57.38 | 10.05 | 28 | 117756 | 812 | 70809848 |
Arthropathy | 57.07 | 10.05 | 101 | 117683 | 149956 | 70660704 |
Affective disorder | 56.68 | 10.05 | 66 | 117718 | 7413 | 70803247 |
H1N1 influenza | 56.39 | 10.05 | 40 | 117744 | 2350 | 70808310 |
Stomatitis | 54.99 | 10.05 | 80 | 117704 | 128431 | 70682229 |
Paranoia | 54.78 | 10.05 | 101 | 117683 | 17187 | 70793473 |
Psychotic disorder | 54.67 | 10.05 | 162 | 117622 | 37539 | 70773121 |
Menstrual disorder | 54.01 | 10.05 | 46 | 117738 | 3540 | 70807120 |
Sleep disorder | 53.47 | 10.05 | 244 | 117540 | 69628 | 70741032 |
Pain | 52.60 | 10.05 | 732 | 117052 | 628084 | 70182576 |
Disease progression | 52.20 | 10.05 | 114 | 117670 | 156558 | 70654102 |
Delusion | 52.19 | 10.05 | 105 | 117679 | 19060 | 70791600 |
Muscle twitching | 52.06 | 10.05 | 107 | 117677 | 19720 | 70790940 |
Feeling of body temperature change | 51.90 | 10.05 | 52 | 117732 | 4927 | 70805733 |
Nasopharyngitis | 51.70 | 10.05 | 192 | 117592 | 222014 | 70588646 |
General physical health deterioration | 51.68 | 10.05 | 209 | 117575 | 235822 | 70574838 |
Lower respiratory tract infection | 51.58 | 10.05 | 66 | 117718 | 111847 | 70698813 |
Loss of consciousness | 51.55 | 10.05 | 438 | 117346 | 155278 | 70655382 |
Amnesia | 50.74 | 10.05 | 196 | 117588 | 51959 | 70758701 |
Neutropenia | 50.64 | 10.05 | 237 | 117547 | 256919 | 70553741 |
COVID-19 | 50.17 | 10.05 | 61 | 117723 | 105696 | 70704964 |
Wound | 50.03 | 10.05 | 54 | 117730 | 98678 | 70711982 |
Abdominal discomfort | 49.60 | 10.05 | 186 | 117598 | 214472 | 70596188 |
Fall | 48.96 | 10.05 | 1021 | 116763 | 443075 | 70367585 |
Hallucination | 48.80 | 10.05 | 253 | 117531 | 76007 | 70734653 |
Parosmia | 48.66 | 10.05 | 50 | 117734 | 4881 | 70805779 |
Dyspnoea | 48.41 | 10.05 | 945 | 116839 | 769115 | 70041545 |
Tinnitus | 48.29 | 10.05 | 151 | 117633 | 36025 | 70774635 |
Emotional distress | 47.60 | 10.05 | 153 | 117631 | 37035 | 70773625 |
Restless legs syndrome | 46.69 | 10.05 | 98 | 117686 | 18330 | 70792330 |
Blood creatine phosphokinase increased | 46.18 | 10.05 | 213 | 117571 | 61050 | 70749610 |
Self esteem decreased | 46.08 | 10.05 | 25 | 117759 | 908 | 70809752 |
Sexual dysfunction | 45.76 | 10.05 | 56 | 117728 | 6625 | 70804035 |
Cytomegalovirus infection | 45.65 | 10.05 | 6 | 117778 | 39752 | 70770908 |
Personality disorder | 45.49 | 10.05 | 51 | 117733 | 5497 | 70805163 |
Infection | 44.67 | 10.05 | 189 | 117595 | 210596 | 70600064 |
Drooling | 44.62 | 10.05 | 50 | 117734 | 5386 | 70805274 |
Muscle disorder | 44.51 | 10.05 | 49 | 117735 | 5176 | 70805484 |
Therapeutic product ineffective | 44.43 | 10.05 | 30 | 117754 | 1627 | 70809033 |
Bronchial haemorrhage | 44.01 | 10.05 | 27 | 117757 | 1240 | 70809420 |
Rheumatoid factor positive | 43.71 | 10.05 | 13 | 117771 | 48387 | 70762273 |
Blepharospasm | 43.51 | 10.05 | 42 | 117742 | 3803 | 70806857 |
Pancytopenia | 43.22 | 10.05 | 119 | 117665 | 150988 | 70659672 |
Hepatocellular injury | 43.04 | 10.05 | 171 | 117613 | 45920 | 70764740 |
Euphoric mood | 42.81 | 10.05 | 55 | 117729 | 6834 | 70803826 |
Galactorrhoea | 42.24 | 10.05 | 39 | 117745 | 3339 | 70807321 |
Hyperprolactinaemia | 42.20 | 10.05 | 44 | 117740 | 4369 | 70806291 |
Neutrophil count decreased | 42.00 | 10.05 | 46 | 117738 | 83510 | 70727150 |
Death | 41.80 | 10.05 | 596 | 117188 | 509465 | 70301195 |
Cardio-respiratory arrest | 41.50 | 10.05 | 298 | 117486 | 100379 | 70710281 |
Abnormal dreams | 41.50 | 10.05 | 68 | 117716 | 10535 | 70800125 |
Gun shot wound | 41.35 | 10.05 | 25 | 117759 | 1118 | 70809542 |
Folliculitis | 41.15 | 10.05 | 10 | 117774 | 42560 | 70768100 |
Logorrhoea | 41.11 | 10.05 | 42 | 117742 | 4072 | 70806588 |
Hyperacusis | 40.91 | 10.05 | 31 | 117753 | 2017 | 70808643 |
Tachycardia | 40.48 | 10.05 | 422 | 117362 | 158124 | 70652536 |
Hostility | 40.40 | 10.05 | 32 | 117752 | 2223 | 70808437 |
Hangover | 40.26 | 10.05 | 30 | 117754 | 1903 | 70808757 |
Seizure | 40.07 | 10.05 | 462 | 117322 | 177500 | 70633160 |
Bipolar disorder | 40.02 | 10.05 | 56 | 117728 | 7552 | 70803108 |
Hallucination, visual | 39.66 | 10.05 | 123 | 117661 | 29214 | 70781446 |
Apraxia | 39.56 | 10.05 | 34 | 117750 | 2649 | 70808011 |
Dizziness | 39.10 | 10.05 | 1028 | 116756 | 463113 | 70347547 |
Erectile dysfunction | 38.97 | 10.05 | 76 | 117708 | 13486 | 70797174 |
Fear | 38.72 | 10.05 | 98 | 117686 | 20713 | 70789947 |
Pyrexia | 38.64 | 10.05 | 743 | 117041 | 606209 | 70204451 |
Discomfort | 38.27 | 10.05 | 73 | 117711 | 105363 | 70705297 |
Hyperthermia | 38.05 | 10.05 | 85 | 117699 | 16586 | 70794074 |
Psoriatic arthropathy | 38.02 | 10.05 | 31 | 117753 | 64740 | 70745920 |
Bradykinesia | 37.66 | 10.05 | 54 | 117730 | 7448 | 70803212 |
Anaemia | 37.56 | 10.05 | 459 | 117325 | 402964 | 70407696 |
Muscle injury | 37.29 | 10.05 | 9 | 117775 | 38485 | 70772175 |
Plasma cell myeloma | 37.13 | 10.05 | 40 | 117744 | 73161 | 70737499 |
Renal ischaemia | 37.03 | 10.05 | 23 | 117761 | 1080 | 70809580 |
Thrombocytopenia | 36.85 | 10.05 | 239 | 117545 | 238871 | 70571789 |
Mobility decreased | 36.79 | 10.05 | 72 | 117712 | 102927 | 70707733 |
Drug abuser | 36.73 | 10.05 | 47 | 117737 | 5817 | 70804843 |
PCO2 increased | 36.61 | 10.05 | 27 | 117757 | 1686 | 70808974 |
Arthralgia | 36.54 | 10.05 | 602 | 117182 | 502788 | 70307872 |
Neuropathy peripheral | 36.24 | 10.05 | 100 | 117684 | 126796 | 70683864 |
Incontinence | 36.22 | 10.05 | 72 | 117712 | 12956 | 70797704 |
Myelosuppression | 35.96 | 10.05 | 4 | 117780 | 30141 | 70780519 |
Substance abuse | 35.71 | 10.05 | 61 | 117723 | 9776 | 70800884 |
Panic disorder | 35.68 | 10.05 | 33 | 117751 | 2831 | 70807829 |
Major depression | 34.93 | 10.05 | 56 | 117728 | 8518 | 70802142 |
Verbal abuse | 34.93 | 10.05 | 14 | 117770 | 250 | 70810410 |
Asphyxia | 34.77 | 10.05 | 62 | 117722 | 10280 | 70800380 |
Septic shock | 34.71 | 10.05 | 85 | 117699 | 112173 | 70698487 |
Visceral congestion | 34.57 | 10.05 | 20 | 117764 | 824 | 70809836 |
Psychomotor hyperactivity | 34.46 | 10.05 | 78 | 117706 | 15355 | 70795305 |
Physical assault | 34.21 | 10.05 | 25 | 117759 | 1539 | 70809121 |
Rhonchi | 34.16 | 10.05 | 36 | 117748 | 3619 | 70807041 |
Atrial fibrillation | 33.90 | 10.05 | 174 | 117610 | 184174 | 70626486 |
Loss of libido | 33.52 | 10.05 | 30 | 117754 | 2467 | 70808193 |
Acute kidney injury | 33.00 | 10.05 | 572 | 117212 | 474052 | 70336608 |
Thinking abnormal | 32.78 | 10.05 | 66 | 117718 | 11985 | 70798675 |
Social anxiety disorder | 32.32 | 10.05 | 16 | 117768 | 479 | 70810181 |
Product complaint | 32.10 | 10.05 | 66 | 117718 | 12165 | 70798495 |
Antidepressant discontinuation syndrome | 32.04 | 10.05 | 7 | 117777 | 9 | 70810651 |
Breath sounds abnormal | 31.94 | 10.05 | 69 | 117715 | 13162 | 70797498 |
Hypoaesthesia oral | 31.84 | 10.05 | 66 | 117718 | 12234 | 70798426 |
Electrocardiogram QT prolonged | 31.46 | 10.05 | 242 | 117542 | 83275 | 70727385 |
Joint hyperextension | 31.08 | 10.05 | 13 | 117771 | 260 | 70810400 |
Bronchial disorder | 31.04 | 10.05 | 28 | 117756 | 2326 | 70808334 |
Apathy | 30.95 | 10.05 | 64 | 117720 | 11844 | 70798816 |
Premature labour | 30.90 | 10.05 | 51 | 117733 | 7949 | 70802711 |
Obsessive-compulsive disorder | 30.47 | 10.05 | 41 | 117743 | 5329 | 70805331 |
Chorea | 29.96 | 10.05 | 26 | 117758 | 2052 | 70808608 |
Ejaculation delayed | 29.96 | 10.05 | 11 | 117773 | 153 | 70810507 |
Anorgasmia | 29.94 | 10.05 | 20 | 117764 | 1065 | 70809595 |
Soft tissue injury | 29.92 | 10.05 | 24 | 117760 | 1698 | 70808962 |
Dependence | 29.63 | 10.05 | 27 | 117757 | 2273 | 70808387 |
Urinary retention | 29.38 | 10.05 | 168 | 117616 | 52352 | 70758308 |
Abdominal pain | 29.33 | 10.05 | 396 | 117388 | 341731 | 70468929 |
Mucosal inflammation | 29.25 | 10.05 | 42 | 117742 | 67808 | 70742852 |
Sensory loss | 29.24 | 10.05 | 61 | 117723 | 11358 | 70799302 |
Mood altered | 29.02 | 10.05 | 76 | 117708 | 16399 | 70794261 |
Poisoning | 28.88 | 10.05 | 93 | 117691 | 22529 | 70788131 |
Depressive symptom | 28.55 | 10.05 | 39 | 117745 | 5142 | 70805518 |
Dysarthria | 28.36 | 10.05 | 189 | 117595 | 62124 | 70748536 |
Oral discharge | 28.33 | 10.05 | 12 | 117772 | 248 | 70810412 |
Anaphylactic reaction | 28.01 | 10.05 | 51 | 117733 | 74923 | 70735737 |
Gastrointestinal disorder | 27.97 | 10.05 | 86 | 117698 | 105341 | 70705319 |
Neutropenic sepsis | 27.91 | 10.05 | 4 | 117780 | 24826 | 70785834 |
Ejaculation failure | 27.56 | 10.05 | 13 | 117771 | 349 | 70810311 |
Hypertonia | 27.24 | 10.05 | 43 | 117741 | 6455 | 70804205 |
Anticholinergic syndrome | 27.23 | 10.05 | 29 | 117755 | 2951 | 70807709 |
Ascites | 27.01 | 10.05 | 44 | 117740 | 67503 | 70743157 |
Coma scale | 26.93 | 10.05 | 8 | 117776 | 54 | 70810606 |
Sensory disturbance | 26.64 | 10.05 | 66 | 117718 | 13766 | 70796894 |
Cerebral microhaemorrhage | 26.63 | 10.05 | 11 | 117773 | 213 | 70810447 |
Head titubation | 26.54 | 10.05 | 17 | 117767 | 843 | 70809817 |
Balance disorder | 26.45 | 10.05 | 247 | 117537 | 89881 | 70720779 |
Respiratory acidosis | 26.42 | 10.05 | 55 | 117729 | 10226 | 70800434 |
Tension | 26.39 | 10.05 | 33 | 117751 | 3991 | 70806669 |
Vision blurred | 26.24 | 10.05 | 257 | 117527 | 94727 | 70715933 |
PO2 increased | 26.18 | 10.05 | 21 | 117763 | 1486 | 70809174 |
Platelet count decreased | 26.01 | 10.05 | 181 | 117603 | 178041 | 70632619 |
Hepatotoxicity | 25.88 | 10.05 | 21 | 117763 | 43965 | 70766695 |
Obsessive thoughts | 25.87 | 10.05 | 18 | 117766 | 1025 | 70809635 |
Sinus tachycardia | 25.62 | 10.05 | 118 | 117666 | 33795 | 70776865 |
Weight increased | 25.62 | 10.05 | 554 | 117230 | 241777 | 70568883 |
Pneumocystis jirovecii pneumonia | 25.54 | 10.05 | 9 | 117775 | 30073 | 70780587 |
Cognitive disorder | 25.44 | 10.05 | 181 | 117603 | 60775 | 70749885 |
White blood cell count decreased | 25.22 | 10.05 | 172 | 117612 | 169969 | 70640691 |
Injection site pain | 25.18 | 10.05 | 105 | 117679 | 117514 | 70693146 |
Chemical submission | 25.17 | 10.05 | 11 | 117773 | 246 | 70810414 |
Electroencephalogram abnormal | 25.16 | 10.05 | 37 | 117747 | 5221 | 70805439 |
Injection site erythema | 25.16 | 10.05 | 52 | 117732 | 72872 | 70737788 |
Post-traumatic neck syndrome | 25.10 | 10.05 | 23 | 117761 | 1950 | 70808710 |
Paralysis | 24.74 | 10.05 | 59 | 117725 | 12013 | 70798647 |
Creutzfeldt-Jakob disease | 24.63 | 10.05 | 10 | 117774 | 185 | 70810475 |
Rhabdomyolysis | 24.48 | 10.05 | 255 | 117529 | 95505 | 70715155 |
Hip arthroplasty | 24.48 | 10.05 | 8 | 117776 | 28032 | 70782628 |
Eye movement disorder | 24.25 | 10.05 | 44 | 117740 | 7396 | 70803264 |
Pain in extremity | 24.21 | 10.05 | 391 | 117393 | 327691 | 70482969 |
Treatment noncompliance | 24.13 | 10.05 | 146 | 117638 | 46428 | 70764232 |
Cytokine release syndrome | 24.10 | 10.05 | 7 | 117777 | 26460 | 70784200 |
Social avoidant behaviour | 24.09 | 10.05 | 34 | 117750 | 4622 | 70806038 |
Feeling abnormal | 23.83 | 10.05 | 350 | 117434 | 141969 | 70668691 |
Congenital hydrocephalus | 23.59 | 10.05 | 7 | 117777 | 47 | 70810613 |
Hypokinesia | 23.48 | 10.05 | 73 | 117711 | 17359 | 70793301 |
Cardiac failure | 23.37 | 10.05 | 141 | 117643 | 143400 | 70667260 |
Pneumonitis | 23.33 | 10.05 | 34 | 117750 | 54563 | 70756097 |
Metastases to liver | 23.28 | 10.05 | 7 | 117777 | 25871 | 70784789 |
Impaired healing | 23.23 | 10.05 | 56 | 117728 | 74318 | 70736342 |
Rhinitis | 23.20 | 10.05 | 56 | 117728 | 11491 | 70799169 |
Accidental poisoning | 22.92 | 10.05 | 20 | 117764 | 1590 | 70809070 |
Psoriasis | 22.90 | 10.05 | 85 | 117699 | 98348 | 70712312 |
Product use in unapproved indication | 22.88 | 10.05 | 227 | 117557 | 207251 | 70603409 |
Diarrhoea | 22.84 | 10.05 | 1066 | 116718 | 782275 | 70028385 |
Multiple organ dysfunction syndrome | 22.54 | 10.05 | 98 | 117686 | 108417 | 70702243 |
Incoherent | 22.29 | 10.05 | 42 | 117742 | 7264 | 70803396 |
Clostridium difficile infection | 22.26 | 10.05 | 19 | 117765 | 38797 | 70771863 |
Prostate cancer | 22.22 | 10.05 | 12 | 117772 | 31151 | 70779509 |
Negative thoughts | 21.74 | 10.05 | 18 | 117766 | 1332 | 70809328 |
Feeling guilty | 21.69 | 10.05 | 15 | 117769 | 846 | 70809814 |
Trichotillomania | 21.66 | 10.05 | 9 | 117775 | 177 | 70810483 |
C-reactive protein increased | 21.64 | 10.05 | 102 | 117682 | 110415 | 70700245 |
Idiosyncratic alcohol intoxication | 21.61 | 10.05 | 4 | 117780 | 0 | 70810660 |
Housebound | 21.53 | 10.05 | 12 | 117772 | 460 | 70810200 |
Product dose omission issue | 21.52 | 10.05 | 244 | 117540 | 217224 | 70593436 |
Frontotemporal dementia | 21.35 | 10.05 | 13 | 117771 | 589 | 70810071 |
Self-injurious ideation | 21.29 | 10.05 | 27 | 117757 | 3311 | 70807349 |
Affect lability | 21.24 | 10.05 | 50 | 117734 | 10096 | 70800564 |
Oedema | 21.23 | 10.05 | 94 | 117690 | 103487 | 70707173 |
Oxygen saturation abnormal | 21.22 | 10.05 | 29 | 117755 | 3825 | 70806835 |
Inadequate analgesia | 21.18 | 10.05 | 30 | 117754 | 4092 | 70806568 |
Mental disorder | 21.14 | 10.05 | 98 | 117686 | 28142 | 70782518 |
Musculoskeletal pain | 21.01 | 10.05 | 78 | 117706 | 90249 | 70720411 |
Sinusitis | 20.86 | 10.05 | 180 | 117604 | 169015 | 70641645 |
Feelings of worthlessness | 20.86 | 10.05 | 12 | 117772 | 489 | 70810171 |
Haemoglobin decreased | 20.77 | 10.05 | 229 | 117555 | 204930 | 70605730 |
Schizophrenia | 20.57 | 10.05 | 68 | 117716 | 16700 | 70793960 |
Irritable bowel syndrome | 20.45 | 10.05 | 33 | 117751 | 50817 | 70759843 |
Arthritis | 20.04 | 10.05 | 89 | 117695 | 97891 | 70712769 |
Psychiatric symptom | 20.03 | 10.05 | 38 | 117746 | 6606 | 70804054 |
Amylase increased | 19.97 | 10.05 | 49 | 117735 | 10159 | 70800501 |
Sternal fracture | 19.94 | 10.05 | 22 | 117762 | 2329 | 70808331 |
Aspergillus infection | 19.80 | 10.05 | 3 | 117781 | 17865 | 70792795 |
Increased appetite | 19.77 | 10.05 | 50 | 117734 | 10563 | 70800097 |
Endocrine ophthalmopathy | 19.64 | 10.05 | 12 | 117772 | 547 | 70810113 |
Posterior reversible encephalopathy syndrome | 19.55 | 10.05 | 8 | 117776 | 24394 | 70786266 |
Blood pH decreased | 19.29 | 10.05 | 30 | 117754 | 4446 | 70806214 |
Blood sodium decreased | 19.24 | 10.05 | 102 | 117682 | 30896 | 70779764 |
Generalised anxiety disorder | 19.19 | 10.05 | 20 | 117764 | 1985 | 70808675 |
Middle insomnia | 19.07 | 10.05 | 59 | 117725 | 13994 | 70796666 |
Somatic dysfunction | 19.00 | 10.05 | 5 | 117779 | 20 | 70810640 |
Erythema | 18.94 | 10.05 | 226 | 117558 | 199337 | 70611323 |
Therapy non-responder | 18.84 | 10.05 | 65 | 117719 | 76850 | 70733810 |
Tardive dyskinesia | 18.73 | 10.05 | 47 | 117737 | 9882 | 70800778 |
Illusion | 18.54 | 10.05 | 18 | 117766 | 1641 | 70809019 |
Maternal exposure during pregnancy | 18.41 | 10.05 | 114 | 117670 | 115231 | 70695429 |
Bradycardia | 18.39 | 10.05 | 300 | 117484 | 124315 | 70686345 |
Judgement impaired | 18.36 | 10.05 | 15 | 117769 | 1089 | 70809571 |
Drug screen positive | 18.35 | 10.05 | 34 | 117750 | 5806 | 70804854 |
Diabetes insipidus | 18.34 | 10.05 | 30 | 117754 | 4641 | 70806019 |
Leukopenia | 18.24 | 10.05 | 103 | 117681 | 106457 | 70704203 |
Brugada syndrome | 18.14 | 10.05 | 15 | 117769 | 1108 | 70809552 |
Hyperlipidaemia | 18.00 | 10.05 | 83 | 117701 | 23780 | 70786880 |
Foetal death | 17.97 | 10.05 | 35 | 117749 | 6204 | 70804456 |
Sedation | 17.92 | 10.05 | 136 | 117648 | 46595 | 70764065 |
Ejaculation disorder | 17.78 | 10.05 | 11 | 117773 | 513 | 70810147 |
Cyanosis | 17.72 | 10.05 | 81 | 117703 | 23125 | 70787535 |
Alcohol abuse | 17.67 | 10.05 | 31 | 117753 | 5076 | 70805584 |
Oropharyngeal pain | 17.64 | 10.05 | 91 | 117693 | 96219 | 70714441 |
Muscle tightness | 17.49 | 10.05 | 51 | 117733 | 11711 | 70798949 |
Poriomania | 17.41 | 10.05 | 8 | 117776 | 202 | 70810458 |
Migraine | 17.36 | 10.05 | 190 | 117594 | 72048 | 70738612 |
Renal impairment | 17.35 | 10.05 | 154 | 117630 | 143783 | 70666877 |
Joint range of motion decreased | 17.17 | 10.05 | 11 | 117773 | 26015 | 70784645 |
Drug resistance | 17.10 | 10.05 | 23 | 117761 | 38167 | 70772493 |
Resting tremor | 16.94 | 10.05 | 16 | 117768 | 1410 | 70809250 |
Myoglobin blood increased | 16.89 | 10.05 | 23 | 117761 | 3024 | 70807636 |
Campylobacter colitis | 16.80 | 10.05 | 5 | 117779 | 34 | 70810626 |
Hypervolaemia | 16.70 | 10.05 | 25 | 117759 | 39681 | 70770979 |
Bronchopulmonary aspergillosis | 16.64 | 10.05 | 7 | 117777 | 20995 | 70789665 |
Encephalopathy | 16.62 | 10.05 | 166 | 117618 | 61495 | 70749165 |
Clumsiness | 16.59 | 10.05 | 22 | 117762 | 2820 | 70807840 |
Soliloquy | 16.43 | 10.05 | 11 | 117773 | 588 | 70810072 |
Hyperkinesia | 16.39 | 10.05 | 21 | 117763 | 2602 | 70808058 |
Inflammation | 16.36 | 10.05 | 71 | 117713 | 78594 | 70732066 |
Poor quality sleep | 16.26 | 10.05 | 72 | 117712 | 20277 | 70790383 |
Vasoplegia syndrome | 16.26 | 10.05 | 23 | 117761 | 3133 | 70807527 |
Dysacusis | 16.21 | 10.05 | 3 | 117781 | 0 | 70810660 |
Phonophobia | 16.09 | 10.05 | 10 | 117774 | 470 | 70810190 |
Knee arthroplasty | 16.03 | 10.05 | 20 | 117764 | 34281 | 70776379 |
Toxicologic test abnormal | 15.97 | 10.05 | 15 | 117769 | 1312 | 70809348 |
Palmar-plantar erythrodysaesthesia syndrome | 15.93 | 10.05 | 16 | 117768 | 30231 | 70780429 |
Thermal burn | 15.86 | 10.05 | 34 | 117750 | 6452 | 70804208 |
Generalised tonic-clonic seizure | 15.84 | 10.05 | 121 | 117663 | 41540 | 70769120 |
Neoplasm progression | 15.81 | 10.05 | 32 | 117752 | 45196 | 70765464 |
Dissociative disorder | 15.75 | 10.05 | 10 | 117774 | 488 | 70810172 |
Tri-iodothyronine free decreased | 15.71 | 10.05 | 9 | 117775 | 364 | 70810296 |
Hospitalisation | 15.70 | 10.05 | 77 | 117707 | 82491 | 70728169 |
Cellulitis | 15.67 | 10.05 | 98 | 117686 | 98830 | 70711830 |
Parkinson's disease | 15.58 | 10.05 | 17 | 117767 | 1778 | 70808882 |
Epistaxis | 15.58 | 10.05 | 103 | 117681 | 102524 | 70708136 |
Tumour lysis syndrome | 15.56 | 10.05 | 8 | 117776 | 21352 | 70789308 |
Altered visual depth perception | 15.53 | 10.05 | 9 | 117775 | 372 | 70810288 |
Intentional device use issue | 15.48 | 10.05 | 5 | 117779 | 46 | 70810614 |
Mental impairment | 15.29 | 10.05 | 63 | 117721 | 17192 | 70793468 |
Compartment syndrome | 15.22 | 10.05 | 27 | 117757 | 4459 | 70806201 |
Vascular stenosis | 15.15 | 10.05 | 10 | 117774 | 522 | 70810138 |
Hypoosmolar state | 15.15 | 10.05 | 8 | 117776 | 275 | 70810385 |
Hypoaesthesia | 15.13 | 10.05 | 348 | 117436 | 153391 | 70657269 |
Persecutory delusion | 15.08 | 10.05 | 27 | 117757 | 4490 | 70806170 |
Influenza like illness | 14.86 | 10.05 | 170 | 117614 | 65161 | 70745499 |
Dissociative amnesia | 14.73 | 10.05 | 6 | 117778 | 112 | 70810548 |
Lactose intolerance | 14.64 | 10.05 | 18 | 117766 | 2140 | 70808520 |
Blood chloride decreased | 14.64 | 10.05 | 37 | 117747 | 7813 | 70802847 |
Hyperventilation | 14.60 | 10.05 | 35 | 117749 | 7151 | 70803509 |
Infusion site scar | 14.58 | 10.05 | 8 | 117776 | 297 | 70810363 |
Amimia | 14.52 | 10.05 | 5 | 117779 | 57 | 70810603 |
Reversible cerebral vasoconstriction syndrome | 14.48 | 10.05 | 20 | 117764 | 2665 | 70807995 |
Cystocele | 14.42 | 10.05 | 11 | 117773 | 723 | 70809937 |
Toxic encephalopathy | 14.41 | 10.05 | 44 | 117740 | 10362 | 70800298 |
Therapy interrupted | 14.39 | 10.05 | 12 | 117772 | 24790 | 70785870 |
Injection site pruritus | 14.35 | 10.05 | 27 | 117757 | 39183 | 70771477 |
Colitis microscopic | 14.31 | 10.05 | 40 | 117744 | 8965 | 70801695 |
Colitis | 14.26 | 10.05 | 56 | 117728 | 63758 | 70746902 |
Antiphospholipid antibodies | 14.26 | 10.05 | 6 | 117778 | 122 | 70810538 |
Impatience | 14.21 | 10.05 | 10 | 117774 | 580 | 70810080 |
Delivery | 14.17 | 10.05 | 10 | 117774 | 583 | 70810077 |
Decreased activity | 14.13 | 10.05 | 36 | 117748 | 7638 | 70803022 |
Alcoholism | 14.12 | 10.05 | 26 | 117758 | 4419 | 70806241 |
Diabetic hyperosmolar coma | 14.09 | 10.05 | 11 | 117773 | 748 | 70809912 |
Wrong patient | 14.09 | 10.05 | 8 | 117776 | 318 | 70810342 |
Respiratory tract infection | 13.98 | 10.05 | 31 | 117753 | 42367 | 70768293 |
Pleural effusion | 13.97 | 10.05 | 147 | 117637 | 132717 | 70677943 |
Fluid retention | 13.93 | 10.05 | 56 | 117728 | 63329 | 70747331 |
Marital problem | 13.92 | 10.05 | 7 | 117777 | 217 | 70810443 |
Epilepsy | 13.84 | 10.05 | 111 | 117673 | 38673 | 70771987 |
Localised infection | 13.82 | 10.05 | 21 | 117763 | 33137 | 70777523 |
Anxiety disorder | 13.80 | 10.05 | 24 | 117760 | 3901 | 70806759 |
Suspiciousness | 13.79 | 10.05 | 10 | 117774 | 608 | 70810052 |
Spinal pain | 13.78 | 10.05 | 3 | 117781 | 13767 | 70796893 |
Fatigue | 13.68 | 10.05 | 1181 | 116603 | 823138 | 69987522 |
Psychomotor skills impaired | 13.54 | 10.05 | 25 | 117759 | 4259 | 70806401 |
Antisocial personality disorder | 13.34 | 10.05 | 4 | 117780 | 28 | 70810632 |
Cholecystitis chronic | 13.31 | 10.05 | 40 | 117744 | 9336 | 70801324 |
Bladder cancer | 13.26 | 10.05 | 6 | 117778 | 17236 | 70793424 |
Laboratory test abnormal | 13.21 | 10.05 | 14 | 117770 | 25809 | 70784851 |
Toxic shock syndrome | 13.21 | 10.05 | 12 | 117772 | 1006 | 70809654 |
Diet refusal | 13.08 | 10.05 | 11 | 117773 | 832 | 70809828 |
Cerebrovascular stenosis | 13.04 | 10.05 | 6 | 117778 | 152 | 70810508 |
Dairy intolerance | 13.04 | 10.05 | 5 | 117779 | 79 | 70810581 |
Impulse-control disorder | 13.03 | 10.05 | 15 | 117769 | 1664 | 70808996 |
Perseveration | 12.91 | 10.05 | 8 | 117776 | 374 | 70810286 |
Subdural haematoma | 12.81 | 10.05 | 88 | 117696 | 29210 | 70781450 |
Catatonia | 12.80 | 10.05 | 36 | 117748 | 8097 | 70802563 |
Urticaria | 12.79 | 10.05 | 192 | 117592 | 162857 | 70647803 |
Blood lactate dehydrogenase increased | 12.79 | 10.05 | 101 | 117683 | 35026 | 70775634 |
Chronic kidney disease | 12.76 | 10.05 | 55 | 117729 | 61002 | 70749658 |
Gaze palsy | 12.72 | 10.05 | 19 | 117765 | 2719 | 70807941 |
Antipsychotic drug level increased | 12.71 | 10.05 | 28 | 117756 | 5412 | 70805248 |
Hypersomnia | 12.67 | 10.05 | 68 | 117716 | 20696 | 70789964 |
Obesity | 12.66 | 10.05 | 82 | 117702 | 26689 | 70783971 |
Posture abnormal | 12.66 | 10.05 | 22 | 117762 | 3574 | 70807086 |
Thought insertion | 12.66 | 10.05 | 4 | 117780 | 34 | 70810626 |
Slow response to stimuli | 12.64 | 10.05 | 15 | 117769 | 1718 | 70808942 |
Violence-related symptom | 12.53 | 10.05 | 10 | 117774 | 702 | 70809958 |
Stupor | 12.47 | 10.05 | 31 | 117753 | 6478 | 70804182 |
Coronary artery disease | 12.42 | 10.05 | 159 | 117625 | 62577 | 70748083 |
Blood triglycerides increased | 12.41 | 10.05 | 65 | 117719 | 19599 | 70791061 |
Intention tremor | 12.39 | 10.05 | 10 | 117774 | 714 | 70809946 |
Injection site reaction | 12.29 | 10.05 | 42 | 117742 | 49810 | 70760850 |
Jealous delusion | 12.29 | 10.05 | 7 | 117777 | 280 | 70810380 |
Bone marrow failure | 12.28 | 10.05 | 41 | 117743 | 48969 | 70761691 |
Ammonia abnormal | 12.26 | 10.05 | 6 | 117778 | 175 | 70810485 |
Hypercholesterolaemia | 12.21 | 10.05 | 61 | 117723 | 18056 | 70792604 |
Dermatitis allergic | 12.20 | 10.05 | 6 | 117778 | 16425 | 70794235 |
Disinhibition | 12.20 | 10.05 | 17 | 117767 | 2284 | 70808376 |
Serum sickness-like reaction | 12.19 | 10.05 | 9 | 117775 | 563 | 70810097 |
Tenosynovitis | 12.18 | 10.05 | 4 | 117780 | 13972 | 70796688 |
Tonic convulsion | 12.09 | 10.05 | 16 | 117768 | 2046 | 70808614 |
Plasmodium vivax infection | 12.06 | 10.05 | 3 | 117781 | 9 | 70810651 |
Ankle fracture | 12.04 | 10.05 | 54 | 117730 | 15290 | 70795370 |
Transaminases increased | 12.01 | 10.05 | 39 | 117745 | 46979 | 70763681 |
Therapeutic response decreased | 12.01 | 10.05 | 53 | 117731 | 58400 | 70752260 |
Nephropathy toxic | 11.98 | 10.05 | 8 | 117776 | 18506 | 70792154 |
Oscillopsia | 11.96 | 10.05 | 6 | 117778 | 185 | 70810475 |
Troponin increased | 11.95 | 10.05 | 57 | 117727 | 16557 | 70794103 |
Aphasia | 11.93 | 10.05 | 117 | 117667 | 43132 | 70767528 |
Device related infection | 11.92 | 10.05 | 22 | 117762 | 32163 | 70778497 |
Dyssomnia | 11.91 | 10.05 | 4 | 117780 | 42 | 70810618 |
Oedema peripheral | 11.90 | 10.05 | 288 | 117496 | 227803 | 70582857 |
Anhedonia | 11.90 | 10.05 | 51 | 117733 | 14162 | 70796498 |
Bacteraemia | 11.80 | 10.05 | 19 | 117765 | 29290 | 70781370 |
Head injury | 11.79 | 10.05 | 97 | 117687 | 34044 | 70776616 |
Fibrocystic breast disease | 11.75 | 10.05 | 9 | 117775 | 595 | 70810065 |
Respiratory depression | 11.71 | 10.05 | 76 | 117708 | 24755 | 70785905 |
Blood pressure systolic increased | 11.71 | 10.05 | 52 | 117732 | 57207 | 70753453 |
Urinary tract infection | 11.68 | 10.05 | 319 | 117465 | 248450 | 70562210 |
Trismus | 11.67 | 10.05 | 26 | 117758 | 5065 | 70805595 |
Autoimmune nephritis | 11.63 | 10.05 | 9 | 117775 | 604 | 70810056 |
Blood aldosterone abnormal | 11.58 | 10.05 | 4 | 117780 | 46 | 70810614 |
Dementia | 11.51 | 10.05 | 70 | 117714 | 22295 | 70788365 |
Exhibitionism | 11.51 | 10.05 | 4 | 117780 | 47 | 70810613 |
Mouth ulceration | 11.42 | 10.05 | 25 | 117759 | 34324 | 70776336 |
Hypervigilance | 11.41 | 10.05 | 8 | 117776 | 461 | 70810199 |
Hyposmia | 11.40 | 10.05 | 9 | 117775 | 622 | 70810038 |
Neurotoxicity | 11.40 | 10.05 | 20 | 117764 | 29806 | 70780854 |
Cyclothymic disorder | 11.34 | 10.05 | 6 | 117778 | 207 | 70810453 |
Enterococcal infection | 11.33 | 10.05 | 5 | 117779 | 14577 | 70796083 |
Paroxysmal arrhythmia | 11.28 | 10.05 | 4 | 117780 | 50 | 70810610 |
Mental status changes | 11.28 | 10.05 | 157 | 117627 | 62944 | 70747716 |
Convulsions local | 11.21 | 10.05 | 4 | 117780 | 51 | 70810609 |
Suicidal behaviour | 11.16 | 10.05 | 19 | 117765 | 3037 | 70807623 |
Granuloma | 11.09 | 10.05 | 33 | 117751 | 7662 | 70802998 |
Blood pressure diastolic decreased | 11.07 | 10.05 | 16 | 117768 | 25764 | 70784896 |
Blood bicarbonate decreased | 11.06 | 10.05 | 25 | 117759 | 4916 | 70805744 |
Feeling of relaxation | 11.04 | 10.05 | 5 | 117779 | 122 | 70810538 |
Hyper IgE syndrome | 11.00 | 10.05 | 8 | 117776 | 489 | 70810171 |
Back pain | 10.92 | 10.05 | 355 | 117429 | 270797 | 70539863 |
Delusional perception | 10.91 | 10.05 | 7 | 117777 | 348 | 70810312 |
Personality change | 10.90 | 10.05 | 36 | 117748 | 8834 | 70801826 |
Administration related reaction | 10.89 | 10.05 | 5 | 117779 | 126 | 70810534 |
Injection site swelling | 10.89 | 10.05 | 36 | 117748 | 43121 | 70767539 |
Ligament sprain | 10.86 | 10.05 | 44 | 117740 | 11919 | 70798741 |
Normetanephrine urine increased | 10.86 | 10.05 | 3 | 117781 | 15 | 70810645 |
Metastases to lung | 10.83 | 10.05 | 7 | 117777 | 16477 | 70794183 |
Ear infection | 10.83 | 10.05 | 19 | 117765 | 28317 | 70782343 |
Decreased interest | 10.77 | 10.05 | 20 | 117764 | 3421 | 70807239 |
Hyperbilirubinaemia | 10.72 | 10.05 | 13 | 117771 | 22555 | 70788105 |
Fibromyalgia | 10.71 | 10.05 | 42 | 117742 | 47832 | 70762828 |
Vasculitis | 10.70 | 10.05 | 10 | 117774 | 19548 | 70791112 |
Yawning | 10.69 | 10.05 | 12 | 117772 | 1295 | 70809365 |
Visual impairment | 10.67 | 10.05 | 190 | 117594 | 80060 | 70730600 |
Energy increased | 10.62 | 10.05 | 18 | 117766 | 2866 | 70807794 |
Loss of personal independence in daily activities | 10.61 | 10.05 | 90 | 117694 | 84820 | 70725840 |
Accommodation disorder | 10.61 | 10.05 | 8 | 117776 | 517 | 70810143 |
Inappropriate schedule of product administration | 10.50 | 10.05 | 121 | 117663 | 107434 | 70703226 |
Prescription form tampering | 10.48 | 10.05 | 7 | 117777 | 373 | 70810287 |
Hyperphagia | 10.43 | 10.05 | 16 | 117768 | 2343 | 70808317 |
Anxiety disorder due to a general medical condition | 10.40 | 10.05 | 3 | 117781 | 18 | 70810642 |
Muscle spasms | 10.39 | 10.05 | 332 | 117452 | 153714 | 70656946 |
Imprisonment | 10.26 | 10.05 | 8 | 117776 | 543 | 70810117 |
Post procedural haematuria | 10.24 | 10.05 | 6 | 117778 | 253 | 70810407 |
Sacroiliac joint dysfunction | 10.22 | 10.05 | 4 | 117780 | 67 | 70810593 |
Job dissatisfaction | 10.22 | 10.05 | 4 | 117780 | 67 | 70810593 |
Abulia | 10.18 | 10.05 | 10 | 117774 | 925 | 70809735 |
Tuberculosis | 10.18 | 10.05 | 6 | 117778 | 14842 | 70795818 |
Liver function test increased | 10.17 | 10.05 | 26 | 117758 | 33821 | 70776839 |
Accidental death | 10.15 | 10.05 | 21 | 117763 | 3887 | 70806773 |
Neurosis | 10.12 | 10.05 | 7 | 117777 | 395 | 70810265 |
Prescription drug used without a prescription | 10.12 | 10.05 | 18 | 117766 | 2979 | 70807681 |
Freezing phenomenon | 10.08 | 10.05 | 13 | 117771 | 1621 | 70809039 |
Pruritus | 10.07 | 10.05 | 470 | 117314 | 345090 | 70465570 |
None
Source | Code | Description |
---|---|---|
ATC | N06AB05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:50908 | agente hepatotoxico |
CHEBI has role | CHEBI:50949 | SSRI |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Premenstrual dysphoric disorder | indication | 596004 | |
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Social phobia | indication | 25501002 | DOID:11257 |
Depressive disorder | indication | 35489007 | |
Posttraumatic stress disorder | indication | 47505003 | DOID:2055 |
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Menopausal flushing | indication | 198436008 | |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Mania | contraindication | 231494001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pathological fracture | contraindication | 268029009 | |
Akathisia | contraindication | 285145004 | |
Pregnancy, function | contraindication | 289908002 | |
Serotonin syndrome | contraindication | 371089000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.51 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8946251 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 9393237 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8658663 | April 6, 2029 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE/5ML | PAROXETINE HYDROCHLORIDE | NOVITIUM PHARMA | A215003 | Sept. 3, 2021 | RX | SUSPENSION | ORAL | March 12, 2022 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 10.40 | CHEMBL | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.65 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | Ki | 5.07 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 7.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 4.52 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 5.42 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.46 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.72 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.42 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.47 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.05 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 6.31 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
Cytochrome P450 1A2 | Enzyme | IC50 | 4.96 | WOMBAT-PK | |||||
Substance-P receptor | GPCR | IC50 | 6.05 | CHEMBL | |||||
Myeloperoxidase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.86 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.33 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.30 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 7.01 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.48 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 9.36 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.70 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.23 | CHEMBL | |||||
Quinolone resistance protein NorA | Transporter | IC50 | 5.15 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.20 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 5.27 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.61 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.89 | CHEMBL |
ID | Source |
---|---|
D02260 | KEGG_DRUG |
110429-35-1 | SECONDARY_CAS_RN |
217797-14-3 | SECONDARY_CAS_RN |
78246-49-8 | SECONDARY_CAS_RN |
4020738 | VANDF |
4020815 | VANDF |
C0070122 | UMLSCUI |
CHEBI:7936 | CHEBI |
8PR | PDB_CHEM_ID |
CHEMBL490 | ChEMBL_ID |
CHEMBL4297919 | ChEMBL_ID |
CHEMBL1200609 | ChEMBL_ID |
DB00715 | DRUGBANK_ID |
CHEMBL1708 | ChEMBL_ID |
CHEMBL1256912 | ChEMBL_ID |
D017374 | MESH_DESCRIPTOR_UI |
43815 | PUBCHEM_CID |
4790 | IUPHAR_LIGAND_ID |
4327 | INN_ID |
41VRH5220H | UNII |
114228 | RXNORM |
18339 | MMSL |
205288 | MMSL |
262886 | MMSL |
29631 | MMSL |
4517 | MMSL |
47422 | MMSL |
5236 | MMSL |
d03157 | MMSL |
004016 | NDDF |
004017 | NDDF |
008361 | NDDF |
321963000 | SNOMEDCT_US |
372595009 | SNOMEDCT_US |
411000220105 | SNOMEDCT_US |
420495003 | SNOMEDCT_US |
96214003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7001 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7001 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7002 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7002 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7004 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7004 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0279 | CAPSULE | 7.50 mg | ORAL | NDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7985 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7985 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8173 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8173 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8174 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8174 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8359 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8359 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5676 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5676 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5677 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5677 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5678 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5678 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5679 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5679 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 37 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-433 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-809 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-248 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-154 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 34 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-154 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 34 sections |