Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 2068 | 61869-08-7 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 5.40 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.53 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 18 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 18 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 13 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1992 | FDA | APOTEX TECHNOLOGIES |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 883.23 | 10.18 | 568 | 96588 | 24513 | 50483455 |
Atrial septal defect | 758.44 | 10.18 | 326 | 96830 | 6015 | 50501953 |
Serotonin syndrome | 588.20 | 10.18 | 440 | 96716 | 24273 | 50483695 |
Suicidal ideation | 446.43 | 10.18 | 541 | 96615 | 54844 | 50453124 |
Ventricular septal defect | 422.40 | 10.18 | 189 | 96967 | 3852 | 50504116 |
Patent ductus arteriosus | 393.99 | 10.18 | 177 | 96979 | 3643 | 50504325 |
Exposure during pregnancy | 368.54 | 10.18 | 755 | 96401 | 120260 | 50387708 |
Sopor | 334.57 | 10.18 | 289 | 96867 | 19590 | 50488378 |
Drug abuse | 326.17 | 10.18 | 483 | 96673 | 59363 | 50448605 |
Suicide attempt | 305.92 | 10.18 | 434 | 96722 | 51298 | 50456670 |
Anxiety | 255.97 | 10.18 | 836 | 96320 | 176770 | 50331198 |
Heart disease congenital | 243.98 | 10.18 | 91 | 97065 | 1135 | 50506833 |
Congenital anomaly | 242.27 | 10.18 | 96 | 97060 | 1425 | 50506543 |
Agitation | 242.18 | 10.18 | 396 | 96760 | 52988 | 50454980 |
Contraindicated product administered | 236.32 | 10.18 | 12 | 97144 | 148946 | 50359022 |
Tremor | 232.84 | 10.18 | 611 | 96545 | 114292 | 50393676 |
Cardiac murmur | 227.95 | 10.18 | 179 | 96977 | 10605 | 50497363 |
Foetal exposure during pregnancy | 224.79 | 10.18 | 270 | 96886 | 27089 | 50480879 |
Mydriasis | 213.07 | 10.18 | 171 | 96985 | 10456 | 50497512 |
Nightmare | 212.17 | 10.18 | 204 | 96952 | 15882 | 50492086 |
Pulmonary valve stenosis | 211.13 | 10.18 | 59 | 97097 | 260 | 50507708 |
Drug ineffective | 210.12 | 10.18 | 838 | 96318 | 818495 | 49689473 |
Joint swelling | 209.04 | 10.18 | 105 | 97051 | 245181 | 50262787 |
Intentional self-injury | 201.30 | 10.18 | 235 | 96921 | 22877 | 50485091 |
Multiple congenital abnormalities | 200.57 | 10.18 | 64 | 97092 | 479 | 50507489 |
Alopecia | 198.38 | 10.18 | 112 | 97044 | 244935 | 50263033 |
Drug intolerance | 189.37 | 10.18 | 92 | 97064 | 219012 | 50288956 |
Off label use | 187.21 | 10.18 | 395 | 96761 | 474031 | 50033937 |
Synovitis | 184.41 | 10.18 | 14 | 97142 | 123851 | 50384117 |
Systemic lupus erythematosus | 181.12 | 10.18 | 27 | 97129 | 140595 | 50367373 |
Drug interaction | 178.85 | 10.18 | 808 | 96348 | 198813 | 50309155 |
Treatment failure | 169.26 | 10.18 | 30 | 97126 | 137607 | 50370361 |
Persistent foetal circulation | 168.97 | 10.18 | 46 | 97110 | 180 | 50507788 |
Irritability | 164.31 | 10.18 | 236 | 96920 | 28190 | 50479778 |
Glossodynia | 164.03 | 10.18 | 16 | 97140 | 115553 | 50392415 |
Depersonalisation/derealisation disorder | 161.23 | 10.18 | 67 | 97089 | 1131 | 50506837 |
Rheumatoid arthritis | 156.24 | 10.18 | 98 | 97058 | 202452 | 50305516 |
Anger | 153.77 | 10.18 | 146 | 97010 | 11187 | 50496781 |
Mania | 152.64 | 10.18 | 143 | 97013 | 10773 | 50497195 |
Somnolence | 152.19 | 10.18 | 645 | 96511 | 154340 | 50353628 |
Pulmonary artery stenosis congenital | 151.47 | 10.18 | 43 | 97113 | 203 | 50507765 |
Rash | 149.46 | 10.18 | 393 | 96763 | 437078 | 50070890 |
Infusion related reaction | 145.23 | 10.18 | 72 | 97084 | 169485 | 50338483 |
Hyponatraemia | 144.11 | 10.18 | 459 | 96697 | 95680 | 50412288 |
Dissociation | 142.14 | 10.18 | 75 | 97081 | 2216 | 50505752 |
Panic attack | 136.64 | 10.18 | 177 | 96979 | 19165 | 50488803 |
Disturbance in attention | 134.21 | 10.18 | 226 | 96930 | 30960 | 50477008 |
Derealisation | 132.40 | 10.18 | 56 | 97100 | 990 | 50506978 |
Disorientation | 131.77 | 10.18 | 241 | 96915 | 35243 | 50472725 |
Neuroleptic malignant syndrome | 131.62 | 10.18 | 133 | 97023 | 10997 | 50496971 |
Coarctation of the aorta | 130.58 | 10.18 | 47 | 97109 | 526 | 50507442 |
Hyperhidrosis | 130.43 | 10.18 | 423 | 96733 | 89003 | 50418965 |
Swelling | 127.10 | 10.18 | 119 | 97037 | 200753 | 50307215 |
Mood swings | 127.03 | 10.18 | 155 | 97001 | 15799 | 50492169 |
Confusional state | 125.62 | 10.18 | 695 | 96461 | 185233 | 50322735 |
Abdominal discomfort | 124.68 | 10.18 | 157 | 96999 | 231484 | 50276484 |
Hallucinations, mixed | 122.72 | 10.18 | 84 | 97072 | 4019 | 50503949 |
Activation syndrome | 121.81 | 10.18 | 35 | 97121 | 174 | 50507794 |
Depression | 121.69 | 10.18 | 633 | 96523 | 164790 | 50343178 |
Aggression | 121.57 | 10.18 | 175 | 96981 | 20941 | 50487027 |
Feeling of despair | 119.38 | 10.18 | 64 | 97092 | 1954 | 50506014 |
Pericarditis | 116.79 | 10.18 | 9 | 97147 | 78680 | 50429288 |
Hypersensitivity | 114.57 | 10.18 | 147 | 97009 | 215014 | 50292954 |
Pain | 114.40 | 10.18 | 649 | 96507 | 578254 | 49929714 |
Completed suicide | 113.61 | 10.18 | 528 | 96628 | 131361 | 50376607 |
Inappropriate antidiuretic hormone secretion | 113.37 | 10.18 | 133 | 97023 | 13010 | 50494958 |
Arthropathy | 112.89 | 10.18 | 83 | 97073 | 157823 | 50350145 |
Fallot's tetralogy | 111.10 | 10.18 | 27 | 97129 | 58 | 50507910 |
Overdose | 110.48 | 10.18 | 431 | 96725 | 99296 | 50408672 |
Peripheral swelling | 109.33 | 10.18 | 141 | 97015 | 205795 | 50302173 |
Restlessness | 109.08 | 10.18 | 183 | 96973 | 24990 | 50482978 |
Bradyphrenia | 108.70 | 10.18 | 92 | 97064 | 6060 | 50501908 |
Developmental delay | 102.60 | 10.18 | 50 | 97106 | 1244 | 50506724 |
Product use issue | 102.47 | 10.18 | 82 | 97074 | 149393 | 50358575 |
Therapeutic product effect decreased | 101.88 | 10.18 | 68 | 97088 | 135982 | 50371986 |
Hallucination, auditory | 100.00 | 10.18 | 113 | 97043 | 10615 | 50497353 |
Gastric pH decreased | 99.24 | 10.18 | 40 | 97116 | 622 | 50507346 |
Withdrawal syndrome | 97.22 | 10.18 | 143 | 97013 | 17447 | 50490521 |
Dyskinesia | 92.00 | 10.18 | 180 | 96976 | 27681 | 50480287 |
Congenital aortic stenosis | 86.62 | 10.18 | 17 | 97139 | 3 | 50507965 |
Transposition of the great vessels | 83.79 | 10.18 | 25 | 97131 | 145 | 50507823 |
Drug dependence | 80.80 | 10.18 | 140 | 97016 | 19619 | 50488349 |
Agoraphobia | 80.30 | 10.18 | 29 | 97127 | 328 | 50507640 |
Hepatic enzyme increased | 79.32 | 10.18 | 88 | 97068 | 137292 | 50370676 |
Delirium | 77.13 | 10.18 | 203 | 96953 | 37989 | 50469979 |
Cogwheel rigidity | 77.09 | 10.18 | 46 | 97110 | 1731 | 50506237 |
Arthralgia | 76.98 | 10.18 | 510 | 96646 | 438192 | 50069776 |
Crying | 76.21 | 10.18 | 139 | 97017 | 20277 | 50487691 |
Febrile neutropenia | 75.58 | 10.18 | 47 | 97109 | 97620 | 50410348 |
Tearfulness | 75.33 | 10.18 | 60 | 97096 | 3627 | 50504341 |
Cough | 73.88 | 10.18 | 228 | 96928 | 241036 | 50266932 |
Insomnia | 73.14 | 10.18 | 580 | 96576 | 174285 | 50333683 |
Talipes | 73.03 | 10.18 | 41 | 97115 | 1373 | 50506595 |
Helicobacter infection | 72.86 | 10.18 | 6 | 97150 | 49696 | 50458272 |
Nasopharyngitis | 72.19 | 10.18 | 165 | 96991 | 192762 | 50315206 |
Discomfort | 69.92 | 10.18 | 63 | 97093 | 108317 | 50399651 |
Toxicity to various agents | 69.21 | 10.18 | 667 | 96489 | 211832 | 50296136 |
Depressed mood | 68.86 | 10.18 | 181 | 96975 | 33842 | 50474126 |
Wound | 68.84 | 10.18 | 61 | 97095 | 105733 | 50402235 |
Homicidal ideation | 68.53 | 10.18 | 42 | 97114 | 1660 | 50506308 |
Lower respiratory tract infection | 68.05 | 10.18 | 50 | 97106 | 95151 | 50412817 |
Emotional disorder | 67.99 | 10.18 | 98 | 97058 | 11738 | 50496230 |
Muscle rigidity | 67.94 | 10.18 | 89 | 97067 | 9740 | 50498228 |
Flat affect | 67.84 | 10.18 | 38 | 97118 | 1267 | 50506701 |
Hypoplastic left heart syndrome | 67.56 | 10.18 | 22 | 97134 | 177 | 50507791 |
Extrapyramidal disorder | 65.49 | 10.18 | 96 | 97060 | 11674 | 50496294 |
Stomatitis | 65.26 | 10.18 | 59 | 97097 | 101285 | 50406683 |
Myoglobin urine present | 63.46 | 10.18 | 25 | 97131 | 365 | 50507603 |
H1N1 influenza | 63.26 | 10.18 | 39 | 97117 | 1558 | 50506410 |
Speech disorder developmental | 62.27 | 10.18 | 28 | 97128 | 577 | 50507391 |
Memory impairment | 61.27 | 10.18 | 308 | 96848 | 79052 | 50428916 |
Bronchial neoplasm | 60.93 | 10.18 | 25 | 97131 | 408 | 50507560 |
Congenital cardiovascular anomaly | 59.82 | 10.18 | 18 | 97138 | 108 | 50507860 |
Abnormal behaviour | 58.92 | 10.18 | 122 | 97034 | 19536 | 50488432 |
Impulsive behaviour | 58.76 | 10.18 | 36 | 97120 | 1422 | 50506546 |
Libido increased | 58.72 | 10.18 | 34 | 97122 | 1209 | 50506759 |
Infection | 58.36 | 10.18 | 156 | 97000 | 172798 | 50335170 |
Blister | 58.33 | 10.18 | 47 | 97109 | 85371 | 50422597 |
Parkinsonism | 57.91 | 10.18 | 78 | 97078 | 8769 | 50499199 |
Altered state of consciousness | 57.66 | 10.18 | 129 | 97027 | 21781 | 50486187 |
Bicuspid aortic valve | 57.07 | 10.18 | 17 | 97139 | 98 | 50507870 |
Hyperreflexia | 56.60 | 10.18 | 59 | 97097 | 5059 | 50502909 |
Bronchial haemorrhage | 56.52 | 10.18 | 25 | 97131 | 495 | 50507473 |
Pulmonary valve stenosis congenital | 56.37 | 10.18 | 18 | 97138 | 135 | 50507833 |
Cleft palate | 55.45 | 10.18 | 30 | 97126 | 933 | 50507035 |
Poisoning deliberate | 55.24 | 10.18 | 72 | 97084 | 7840 | 50500128 |
Dystonia | 54.75 | 10.18 | 89 | 97067 | 11837 | 50496131 |
Intentional product use issue | 54.19 | 10.18 | 41 | 97115 | 76877 | 50431091 |
Homicide | 54.13 | 10.18 | 22 | 97134 | 350 | 50507618 |
Nervousness | 53.83 | 10.18 | 145 | 97011 | 27506 | 50480462 |
Nasal turbinate hypertrophy | 53.45 | 10.18 | 26 | 97130 | 644 | 50507324 |
Myoclonus | 53.35 | 10.18 | 98 | 97058 | 14372 | 50493596 |
Anomalous pulmonary venous connection | 52.21 | 10.18 | 14 | 97142 | 51 | 50507917 |
Pneumonia | 52.15 | 10.18 | 470 | 96686 | 377931 | 50130037 |
Amnesia | 52.02 | 10.18 | 189 | 96967 | 42071 | 50465897 |
Hypomania | 51.74 | 10.18 | 53 | 97103 | 4452 | 50503516 |
Clonus | 51.40 | 10.18 | 51 | 97105 | 4124 | 50503844 |
Intentional overdose | 51.39 | 10.18 | 247 | 96909 | 62257 | 50445711 |
Right ventricular hypertrophy | 50.75 | 10.18 | 25 | 97131 | 637 | 50507331 |
Drooling | 50.54 | 10.18 | 46 | 97110 | 3338 | 50504630 |
Cyanosis | 50.00 | 10.18 | 98 | 97058 | 15086 | 50492882 |
Feeling jittery | 49.50 | 10.18 | 82 | 97074 | 11078 | 50496890 |
Feeling of body temperature change | 49.47 | 10.18 | 51 | 97105 | 4316 | 50503652 |
Death | 49.37 | 10.18 | 394 | 96762 | 324985 | 50182983 |
Affective disorder | 49.01 | 10.18 | 55 | 97101 | 5126 | 50502842 |
Maternal exposure during pregnancy | 48.86 | 10.18 | 151 | 97005 | 159627 | 50348341 |
Paraesthesia | 48.15 | 10.18 | 395 | 96761 | 119848 | 50388120 |
Vertigo | 47.92 | 10.18 | 212 | 96944 | 51620 | 50456348 |
Renal ischaemia | 47.68 | 10.18 | 23 | 97133 | 559 | 50507409 |
Endometrial ablation | 47.24 | 10.18 | 26 | 97130 | 837 | 50507131 |
Folliculitis | 47.21 | 10.18 | 9 | 97147 | 39216 | 50468752 |
Depressed level of consciousness | 46.90 | 10.18 | 211 | 96945 | 51742 | 50456226 |
Delusion | 46.00 | 10.18 | 77 | 97079 | 10492 | 50497476 |
Menstrual disorder | 45.87 | 10.18 | 49 | 97107 | 4321 | 50503647 |
Malignant neoplasm progression | 45.87 | 10.18 | 38 | 97118 | 68086 | 50439882 |
Muscle injury | 45.78 | 10.18 | 8 | 97148 | 37103 | 50470865 |
Speech disorder | 45.47 | 10.18 | 161 | 96995 | 35387 | 50472581 |
Self esteem decreased | 45.15 | 10.18 | 22 | 97134 | 547 | 50507421 |
Psychotic disorder | 45.12 | 10.18 | 117 | 97039 | 21695 | 50486273 |
Loss of libido | 43.75 | 10.18 | 28 | 97128 | 1195 | 50506773 |
Dependence | 43.72 | 10.18 | 33 | 97123 | 1842 | 50506126 |
Hallucination | 43.25 | 10.18 | 191 | 96965 | 46466 | 50461502 |
Abnormal dreams | 43.08 | 10.18 | 70 | 97086 | 9307 | 50498661 |
Therapeutic product ineffective | 42.79 | 10.18 | 28 | 97128 | 1242 | 50506726 |
Craniosynostosis | 42.66 | 10.18 | 15 | 97141 | 156 | 50507812 |
Apathy | 42.63 | 10.18 | 62 | 97094 | 7486 | 50500482 |
Dizziness | 42.34 | 10.18 | 915 | 96241 | 345454 | 50162514 |
Parosmia | 41.81 | 10.18 | 47 | 97109 | 4389 | 50503579 |
Tinnitus | 41.81 | 10.18 | 134 | 97022 | 27998 | 50479970 |
Neutropenia | 41.66 | 10.18 | 145 | 97011 | 147820 | 50360148 |
Akathisia | 41.34 | 10.18 | 64 | 97092 | 8165 | 50499803 |
Hyperprolactinaemia | 41.23 | 10.18 | 41 | 97115 | 3324 | 50504644 |
Mobility decreased | 41.08 | 10.18 | 56 | 97100 | 79892 | 50428076 |
Accidental poisoning | 41.05 | 10.18 | 21 | 97135 | 581 | 50507387 |
Spina bifida | 40.94 | 10.18 | 22 | 97134 | 675 | 50507293 |
PCO2 increased | 40.47 | 10.18 | 26 | 97130 | 1117 | 50506851 |
Hyperacusis | 40.41 | 10.18 | 31 | 97125 | 1773 | 50506195 |
Fatigue | 40.11 | 10.18 | 1044 | 96112 | 706557 | 49801411 |
Galactorrhoea | 39.53 | 10.18 | 42 | 97114 | 3681 | 50504287 |
Logorrhoea | 39.51 | 10.18 | 34 | 97122 | 2290 | 50505678 |
Social anxiety disorder | 39.51 | 10.18 | 18 | 97138 | 383 | 50507585 |
Chorea | 39.05 | 10.18 | 27 | 97129 | 1313 | 50506655 |
Incontinence | 38.56 | 10.18 | 69 | 97087 | 9916 | 50498052 |
Muscle twitching | 38.54 | 10.18 | 89 | 97067 | 15342 | 50492626 |
Bronchial disorder | 38.04 | 10.18 | 25 | 97131 | 1117 | 50506851 |
Muscle disorder | 37.48 | 10.18 | 44 | 97112 | 4306 | 50503662 |
Libido decreased | 36.87 | 10.18 | 33 | 97123 | 2343 | 50505625 |
Congenital mitral valve stenosis | 36.80 | 10.18 | 7 | 97149 | 0 | 50507968 |
Paranoia | 36.79 | 10.18 | 69 | 97087 | 10279 | 50497689 |
Injection site pain | 36.78 | 10.18 | 101 | 97055 | 110923 | 50397045 |
Product complaint | 36.54 | 10.18 | 73 | 97083 | 11393 | 50496575 |
Hostility | 36.41 | 10.18 | 29 | 97127 | 1753 | 50506215 |
Hypoaesthesia oral | 36.25 | 10.18 | 70 | 97086 | 10658 | 50497310 |
Restless legs syndrome | 35.72 | 10.18 | 88 | 97068 | 15809 | 50492159 |
Psychomotor hyperactivity | 35.56 | 10.18 | 64 | 97092 | 9237 | 50498731 |
Impaired healing | 34.73 | 10.18 | 50 | 97106 | 69736 | 50438232 |
Sinusitis | 34.68 | 10.18 | 189 | 96967 | 170369 | 50337599 |
Seizure | 34.45 | 10.18 | 362 | 96794 | 117512 | 50390456 |
Neuropathy peripheral | 34.36 | 10.18 | 85 | 97071 | 96672 | 50411296 |
Gastrointestinal disorder | 34.31 | 10.18 | 82 | 97074 | 94374 | 50413594 |
Obsessive-compulsive disorder | 34.27 | 10.18 | 37 | 97119 | 3303 | 50504665 |
General physical health deterioration | 34.06 | 10.18 | 149 | 97007 | 142285 | 50365683 |
Urinary retention | 33.82 | 10.18 | 119 | 97037 | 26071 | 50481897 |
Dyspnoea | 33.38 | 10.18 | 799 | 96357 | 546809 | 49961159 |
Tachycardia | 33.33 | 10.18 | 315 | 96841 | 99448 | 50408520 |
Ventricular hypoplasia | 32.74 | 10.18 | 12 | 97144 | 142 | 50507826 |
Self-injurious ideation | 32.70 | 10.18 | 30 | 97126 | 2199 | 50505769 |
Hip arthroplasty | 32.60 | 10.18 | 9 | 97147 | 30420 | 50477548 |
Knee arthroplasty | 32.54 | 10.18 | 14 | 97142 | 35832 | 50472136 |
PO2 increased | 32.37 | 10.18 | 20 | 97136 | 802 | 50507166 |
Neonatal behavioural syndrome | 32.14 | 10.18 | 9 | 97147 | 40 | 50507928 |
Fear | 32.13 | 10.18 | 80 | 97076 | 14469 | 50493499 |
Rhonchi | 31.82 | 10.18 | 30 | 97126 | 2277 | 50505691 |
Pain in extremity | 31.67 | 10.18 | 353 | 96803 | 272512 | 50235456 |
Congenital aortic valve incompetence | 31.55 | 10.18 | 6 | 97150 | 0 | 50507968 |
DiGeorge's syndrome | 31.55 | 10.18 | 6 | 97150 | 0 | 50507968 |
Hallucination, visual | 31.31 | 10.18 | 86 | 97070 | 16496 | 50491472 |
Disease progression | 31.17 | 10.18 | 88 | 97068 | 95778 | 50412190 |
Balance disorder | 31.04 | 10.18 | 237 | 96919 | 70353 | 50437615 |
Emotional distress | 30.98 | 10.18 | 123 | 97033 | 28540 | 50479428 |
Arthritis | 30.94 | 10.18 | 76 | 97080 | 86645 | 50421323 |
Thermal burn | 30.65 | 10.18 | 42 | 97114 | 4799 | 50503169 |
Sepsis | 30.61 | 10.18 | 141 | 97015 | 132784 | 50375184 |
Maternal drugs affecting foetus | 30.57 | 10.18 | 43 | 97113 | 5034 | 50502934 |
Injection site erythema | 30.56 | 10.18 | 61 | 97095 | 74875 | 50433093 |
Depressive symptom | 30.32 | 10.18 | 34 | 97122 | 3166 | 50504802 |
Cerebral microhaemorrhage | 30.12 | 10.18 | 10 | 97146 | 86 | 50507882 |
Diabetes insipidus | 29.33 | 10.18 | 29 | 97127 | 2335 | 50505633 |
Apraxia | 29.15 | 10.18 | 24 | 97132 | 1521 | 50506447 |
Product dose omission issue | 29.05 | 10.18 | 220 | 96936 | 183618 | 50324350 |
Ebstein's anomaly | 28.82 | 10.18 | 7 | 97149 | 15 | 50507953 |
Paralysis | 28.62 | 10.18 | 56 | 97100 | 8608 | 50499360 |
Coma scale | 28.14 | 10.18 | 8 | 97148 | 38 | 50507930 |
Personality disorder | 28.11 | 10.18 | 38 | 97118 | 4286 | 50503682 |
Prescription form tampering | 28.07 | 10.18 | 16 | 97140 | 552 | 50507416 |
COVID-19 | 27.90 | 10.18 | 29 | 97127 | 46633 | 50461335 |
Soft tissue injury | 27.89 | 10.18 | 23 | 97133 | 1461 | 50506507 |
Hepatocellular injury | 27.77 | 10.18 | 111 | 97045 | 25836 | 50482132 |
Respiratory depression | 27.54 | 10.18 | 67 | 97089 | 11943 | 50496025 |
Micrognathia | 27.53 | 10.18 | 12 | 97144 | 229 | 50507739 |
Loss of consciousness | 27.51 | 10.18 | 314 | 96842 | 104039 | 50403929 |
Schizophrenia | 27.14 | 10.18 | 50 | 97106 | 7347 | 50500621 |
Sensory disturbance | 27.13 | 10.18 | 66 | 97090 | 11763 | 50496205 |
Neutrophil count decreased | 27.07 | 10.18 | 29 | 97127 | 45997 | 50461971 |
Feelings of worthlessness | 27.06 | 10.18 | 13 | 97143 | 313 | 50507655 |
Encephalopathy | 26.82 | 10.18 | 132 | 97024 | 33579 | 50474389 |
Soliloquy | 26.72 | 10.18 | 11 | 97145 | 181 | 50507787 |
Blood pH decreased | 26.61 | 10.18 | 28 | 97128 | 2427 | 50505541 |
Cardiomegaly | 26.52 | 10.18 | 79 | 97077 | 15866 | 50492102 |
Breath sounds abnormal | 26.52 | 10.18 | 51 | 97105 | 7741 | 50500227 |
Vesicoureteric reflux | 26.29 | 10.18 | 11 | 97145 | 189 | 50507779 |
Electroencephalogram abnormal | 26.25 | 10.18 | 33 | 97123 | 3466 | 50504502 |
Alcoholism | 26.13 | 10.18 | 23 | 97133 | 1597 | 50506371 |
Sleep disorder | 26.13 | 10.18 | 194 | 96962 | 57089 | 50450879 |
Weight increased | 26.12 | 10.18 | 538 | 96618 | 201353 | 50306615 |
Creutzfeldt-Jakob disease | 26.09 | 10.18 | 10 | 97146 | 135 | 50507833 |
Blood creatine phosphokinase increased | 26.01 | 10.18 | 110 | 97046 | 26257 | 50481711 |
Fall | 25.83 | 10.18 | 833 | 96323 | 334099 | 50173869 |
Bronchopulmonary dysplasia | 25.72 | 10.18 | 12 | 97144 | 270 | 50507698 |
Irritable bowel syndrome | 25.45 | 10.18 | 37 | 97119 | 51404 | 50456564 |
Joint hyperextension | 25.21 | 10.18 | 12 | 97144 | 283 | 50507685 |
Blood sodium decreased | 24.70 | 10.18 | 93 | 97063 | 21054 | 50486914 |
Musculoskeletal stiffness | 24.68 | 10.18 | 145 | 97011 | 128336 | 50379632 |
Electrocardiogram QT prolonged | 24.39 | 10.18 | 177 | 96979 | 51709 | 50456259 |
Obsessive thoughts | 24.25 | 10.18 | 14 | 97142 | 495 | 50507473 |
Cytomegalovirus infection | 24.16 | 10.18 | 3 | 97153 | 17959 | 50490009 |
Compartment syndrome | 24.01 | 10.18 | 24 | 97132 | 1958 | 50506010 |
Dysmorphism | 23.99 | 10.18 | 25 | 97131 | 2142 | 50505826 |
Treatment noncompliance | 23.95 | 10.18 | 118 | 97038 | 30032 | 50477936 |
White blood cell count decreased | 23.90 | 10.18 | 129 | 97027 | 116593 | 50391375 |
Congenital heart valve disorder | 23.88 | 10.18 | 8 | 97148 | 71 | 50507897 |
Congenital tricuspid valve atresia | 23.70 | 10.18 | 7 | 97149 | 39 | 50507929 |
Mental disorder | 23.47 | 10.18 | 94 | 97062 | 21897 | 50486071 |
Cardio-respiratory arrest | 23.16 | 10.18 | 180 | 96976 | 53712 | 50454256 |
Tricuspid valve incompetence | 22.90 | 10.18 | 65 | 97091 | 12705 | 50495263 |
Post-traumatic neck syndrome | 22.90 | 10.18 | 23 | 97133 | 1887 | 50506081 |
Cleft lip and palate | 22.85 | 10.18 | 12 | 97144 | 351 | 50507617 |
Oxygen saturation abnormal | 22.73 | 10.18 | 27 | 97129 | 2675 | 50505293 |
Panic reaction | 22.65 | 10.18 | 31 | 97125 | 3538 | 50504430 |
Aortic valve incompetence | 22.64 | 10.18 | 39 | 97117 | 5437 | 50502531 |
Aorta hypoplasia | 22.56 | 10.18 | 9 | 97147 | 136 | 50507832 |
Eye movement disorder | 22.35 | 10.18 | 35 | 97121 | 4510 | 50503458 |
Vision blurred | 22.25 | 10.18 | 240 | 96916 | 78407 | 50429561 |
Tension | 22.25 | 10.18 | 27 | 97129 | 2735 | 50505233 |
Substance abuse | 22.03 | 10.18 | 33 | 97123 | 4091 | 50503877 |
Sensory loss | 21.99 | 10.18 | 47 | 97109 | 7691 | 50500277 |
Mood altered | 21.93 | 10.18 | 64 | 97092 | 12709 | 50495259 |
Poor quality sleep | 21.81 | 10.18 | 76 | 97080 | 16570 | 50491398 |
Mucosal inflammation | 21.76 | 10.18 | 27 | 97129 | 40115 | 50467853 |
Phonophobia | 21.71 | 10.18 | 11 | 97145 | 298 | 50507670 |
Wolff-Parkinson-White syndrome | 21.50 | 10.18 | 8 | 97148 | 99 | 50507869 |
Altered visual depth perception | 21.48 | 10.18 | 11 | 97145 | 305 | 50507663 |
Pulmonary artery stenosis | 21.33 | 10.18 | 9 | 97147 | 158 | 50507810 |
Middle insomnia | 21.33 | 10.18 | 54 | 97102 | 9867 | 50498101 |
Hypoplastic right heart syndrome | 21.31 | 10.18 | 7 | 97149 | 58 | 50507910 |
Pancytopenia | 21.26 | 10.18 | 86 | 97070 | 83944 | 50424024 |
Psoriatic arthropathy | 21.21 | 10.18 | 36 | 97120 | 46996 | 50460972 |
Anaphylactic reaction | 21.20 | 10.18 | 45 | 97111 | 54010 | 50453958 |
Hepatotoxicity | 21.19 | 10.18 | 13 | 97143 | 27213 | 50480755 |
Congenital aortic atresia | 21.03 | 10.18 | 4 | 97152 | 0 | 50507968 |
Pilonidal cyst congenital | 21.03 | 10.18 | 4 | 97152 | 0 | 50507968 |
Euphoric mood | 21.02 | 10.18 | 32 | 97124 | 4023 | 50503945 |
Dilatation ventricular | 20.84 | 10.18 | 24 | 97132 | 2301 | 50505667 |
Psychiatric symptom | 20.83 | 10.18 | 34 | 97122 | 4536 | 50503432 |
Musculoskeletal pain | 20.79 | 10.18 | 70 | 97086 | 72107 | 50435861 |
Somnolence neonatal | 20.74 | 10.18 | 8 | 97148 | 110 | 50507858 |
Oropharyngeal pain | 20.72 | 10.18 | 78 | 97078 | 77723 | 50430245 |
Blood triglycerides increased | 20.70 | 10.18 | 58 | 97098 | 11254 | 50496714 |
Anorgasmia | 20.59 | 10.18 | 13 | 97143 | 542 | 50507426 |
Ventricular hypertrophy | 20.51 | 10.18 | 28 | 97128 | 3187 | 50504781 |
Leukopenia | 20.49 | 10.18 | 64 | 97092 | 67464 | 50440504 |
Asphyxia | 20.31 | 10.18 | 37 | 97119 | 5390 | 50502578 |
Generalised anxiety disorder | 20.16 | 10.18 | 21 | 97135 | 1799 | 50506169 |
Pruritus | 20.01 | 10.18 | 404 | 96752 | 283164 | 50224804 |
Hypokinesia | 19.82 | 10.18 | 60 | 97096 | 12157 | 50495811 |
Negative thoughts | 19.66 | 10.18 | 15 | 97141 | 851 | 50507117 |
Metastases to liver | 19.65 | 10.18 | 7 | 97149 | 20097 | 50487871 |
Dysarthria | 19.58 | 10.18 | 131 | 97025 | 37272 | 50470696 |
Feeling abnormal | 19.50 | 10.18 | 344 | 96812 | 125148 | 50382820 |
Back pain | 19.49 | 10.18 | 301 | 96855 | 219729 | 50288239 |
Sinus tachycardia | 19.47 | 10.18 | 87 | 97069 | 21267 | 50486701 |
Pneumonitis | 19.20 | 10.18 | 17 | 97139 | 29493 | 50478475 |
Poisoning | 19.19 | 10.18 | 60 | 97096 | 12369 | 50495599 |
Amylase increased | 19.04 | 10.18 | 36 | 97120 | 5394 | 50502574 |
Physical assault | 19.03 | 10.18 | 15 | 97141 | 893 | 50507075 |
Antidepressant discontinuation syndrome | 18.91 | 10.18 | 5 | 97151 | 17 | 50507951 |
Posterior reversible encephalopathy syndrome | 18.89 | 10.18 | 3 | 97153 | 14925 | 50493043 |
Aphasia | 18.84 | 10.18 | 106 | 97050 | 28388 | 50479580 |
Therapy non-responder | 18.76 | 10.18 | 44 | 97112 | 50978 | 50456990 |
Delivery | 18.62 | 10.18 | 13 | 97143 | 642 | 50507326 |
Pyrexia | 18.60 | 10.18 | 572 | 96584 | 379631 | 50128337 |
Failure to thrive | 18.51 | 10.18 | 39 | 97117 | 6319 | 50501649 |
Injection site reaction | 18.51 | 10.18 | 43 | 97113 | 49989 | 50457979 |
Sternal fracture | 18.51 | 10.18 | 21 | 97135 | 1981 | 50505987 |
Premature baby | 18.48 | 10.18 | 77 | 97079 | 18260 | 50489708 |
Plagiocephaly | 18.45 | 10.18 | 6 | 97150 | 48 | 50507920 |
Foetal movement disorder | 18.27 | 10.18 | 4 | 97152 | 4 | 50507964 |
Right ventricle outflow tract obstruction | 18.27 | 10.18 | 4 | 97152 | 4 | 50507964 |
Hypotonia | 18.25 | 10.18 | 45 | 97111 | 8089 | 50499879 |
Hot flush | 18.14 | 10.18 | 146 | 97010 | 44023 | 50463945 |
Velopharyngeal incompetence | 18.08 | 10.18 | 5 | 97151 | 21 | 50507947 |
Macular degeneration | 17.97 | 10.18 | 3 | 97153 | 14385 | 50493583 |
Red blood cell sedimentation rate increased | 17.90 | 10.18 | 18 | 97138 | 29398 | 50478570 |
Blood bicarbonate decreased | 17.79 | 10.18 | 24 | 97132 | 2701 | 50505267 |
Upper respiratory tract infection | 17.59 | 10.18 | 66 | 97090 | 65832 | 50442136 |
Slow response to stimuli | 17.45 | 10.18 | 14 | 97142 | 855 | 50507113 |
Hypertonia | 17.36 | 10.18 | 29 | 97127 | 3944 | 50504024 |
Injection site pruritus | 17.26 | 10.18 | 32 | 97124 | 40379 | 50467589 |
Coma | 17.23 | 10.18 | 176 | 96980 | 56703 | 50451265 |
Inflammation | 17.22 | 10.18 | 54 | 97102 | 56858 | 50451110 |
Apnoea | 17.20 | 10.18 | 40 | 97116 | 6926 | 50501042 |
Pulmonary valve incompetence | 17.17 | 10.18 | 16 | 97140 | 1197 | 50506771 |
Drug abuser | 17.10 | 10.18 | 24 | 97132 | 2804 | 50505164 |
Congenital aortic anomaly | 17.10 | 10.18 | 6 | 97150 | 62 | 50507906 |
Arnold-Chiari malformation | 16.97 | 10.18 | 11 | 97145 | 480 | 50507488 |
Hospitalisation | 16.89 | 10.18 | 70 | 97086 | 67867 | 50440101 |
Urticaria | 16.89 | 10.18 | 163 | 96993 | 129398 | 50378570 |
Anaemia | 16.82 | 10.18 | 363 | 96793 | 252093 | 50255875 |
Trichotillomania | 16.80 | 10.18 | 7 | 97149 | 119 | 50507849 |
Mitral valve incompetence | 16.55 | 10.18 | 72 | 97084 | 17399 | 50490569 |
Myelosuppression | 16.48 | 10.18 | 3 | 97153 | 13514 | 50494454 |
Otospondylomegaepiphyseal dysplasia | 16.45 | 10.18 | 6 | 97150 | 70 | 50507898 |
Therapeutic response decreased | 16.37 | 10.18 | 42 | 97114 | 47189 | 50460779 |
Campylobacter colitis | 16.34 | 10.18 | 5 | 97151 | 32 | 50507936 |
Psychomotor skills impaired | 16.34 | 10.18 | 20 | 97136 | 2044 | 50505924 |
Antisocial personality disorder | 16.33 | 10.18 | 4 | 97152 | 9 | 50507959 |
Cleft uvula | 16.33 | 10.18 | 4 | 97152 | 9 | 50507959 |
Myoglobin blood increased | 16.30 | 10.18 | 16 | 97140 | 1277 | 50506691 |
Illusion | 16.24 | 10.18 | 14 | 97142 | 945 | 50507023 |
Intentional device use issue | 16.21 | 10.18 | 5 | 97151 | 33 | 50507935 |
Disinhibition | 16.16 | 10.18 | 13 | 97143 | 797 | 50507171 |
Poriomania | 16.07 | 10.18 | 6 | 97150 | 75 | 50507893 |
Neonatal asphyxia | 15.95 | 10.18 | 8 | 97148 | 212 | 50507756 |
Congenital tracheomalacia | 15.84 | 10.18 | 5 | 97151 | 36 | 50507932 |
Diarrhoea | 15.83 | 10.18 | 947 | 96209 | 587529 | 49920439 |
Bipolar disorder | 15.82 | 10.18 | 38 | 97118 | 6719 | 50501249 |
Mental impairment | 15.79 | 10.18 | 55 | 97101 | 11989 | 50495979 |
Lipomeningocele | 15.77 | 10.18 | 3 | 97153 | 0 | 50507968 |
Interruption of aortic arch | 15.77 | 10.18 | 3 | 97153 | 0 | 50507968 |
Subvalvular aortic stenosis | 15.77 | 10.18 | 3 | 97153 | 0 | 50507968 |
Bradycardia | 15.70 | 10.18 | 191 | 96965 | 64235 | 50443733 |
Post procedural haematuria | 15.60 | 10.18 | 5 | 97151 | 38 | 50507930 |
Autoimmune nephritis | 15.57 | 10.18 | 9 | 97147 | 319 | 50507649 |
Parkinson's disease | 15.46 | 10.18 | 15 | 97141 | 1180 | 50506788 |
Tethered cord syndrome | 15.45 | 10.18 | 8 | 97148 | 227 | 50507741 |
Congenital scoliosis | 15.27 | 10.18 | 4 | 97152 | 13 | 50507955 |
Toxic encephalopathy | 15.10 | 10.18 | 33 | 97123 | 5482 | 50502486 |
Cognitive disorder | 15.06 | 10.18 | 140 | 97016 | 43983 | 50463985 |
Localised infection | 15.05 | 10.18 | 16 | 97140 | 25469 | 50482499 |
Dextrocardia | 15.04 | 10.18 | 4 | 97152 | 14 | 50507954 |
Foetal death | 15.02 | 10.18 | 42 | 97114 | 8138 | 50499830 |
Tardive dyskinesia | 15.00 | 10.18 | 39 | 97117 | 7240 | 50500728 |
Urinary tract infection | 14.95 | 10.18 | 322 | 96834 | 223698 | 50284270 |
Drug resistance | 14.87 | 10.18 | 9 | 97147 | 18980 | 50488988 |
VACTERL syndrome | 14.83 | 10.18 | 4 | 97152 | 15 | 50507953 |
Atrioventricular septal defect | 14.67 | 10.18 | 8 | 97148 | 253 | 50507715 |
Perseveration | 14.61 | 10.18 | 8 | 97148 | 255 | 50507713 |
Thinking abnormal | 14.60 | 10.18 | 46 | 97110 | 9521 | 50498447 |
Diabetic hyperosmolar coma | 14.59 | 10.18 | 9 | 97147 | 360 | 50507608 |
Ear infection | 14.57 | 10.18 | 17 | 97139 | 25953 | 50482015 |
Blood pressure diastolic decreased | 14.54 | 10.18 | 7 | 97149 | 16774 | 50491194 |
Abdominal pain | 14.50 | 10.18 | 344 | 96812 | 235884 | 50272084 |
Endocrine ophthalmopathy | 14.50 | 10.18 | 9 | 97147 | 364 | 50507604 |
Thrombocytopenia | 14.45 | 10.18 | 166 | 96990 | 127507 | 50380461 |
C-reactive protein increased | 14.43 | 10.18 | 72 | 97084 | 66402 | 50441566 |
Social avoidant behaviour | 14.40 | 10.18 | 22 | 97134 | 2775 | 50505193 |
Amimia | 14.39 | 10.18 | 5 | 97151 | 50 | 50507918 |
Granuloma | 14.38 | 10.18 | 30 | 97126 | 4828 | 50503140 |
Alcohol abuse | 14.37 | 10.18 | 18 | 97138 | 1883 | 50506085 |
Lactose intolerance | 14.35 | 10.18 | 21 | 97135 | 2549 | 50505419 |
Blood pressure systolic increased | 14.33 | 10.18 | 29 | 97127 | 35420 | 50472548 |
Major depression | 14.31 | 10.18 | 37 | 97119 | 6847 | 50501121 |
Female orgasmic disorder | 14.31 | 10.18 | 5 | 97151 | 51 | 50507917 |
Dairy intolerance | 14.31 | 10.18 | 5 | 97151 | 51 | 50507917 |
Condition aggravated | 14.25 | 10.18 | 448 | 96708 | 296610 | 50211358 |
Gaze palsy | 14.09 | 10.18 | 15 | 97141 | 1318 | 50506650 |
Oesophageal atresia | 13.92 | 10.18 | 10 | 97146 | 517 | 50507451 |
Feeling guilty | 13.87 | 10.18 | 10 | 97146 | 520 | 50507448 |
Premature labour | 13.84 | 10.18 | 51 | 97105 | 11425 | 50496543 |
Anhedonia | 13.82 | 10.18 | 45 | 97111 | 9479 | 50498489 |
Blood lactate dehydrogenase increased | 13.75 | 10.18 | 74 | 97082 | 19488 | 50488480 |
Erythema | 13.75 | 10.18 | 198 | 96958 | 146216 | 50361752 |
Leucine aminopeptidase increased | 13.70 | 10.18 | 3 | 97153 | 3 | 50507965 |
Dyskinesia neonatal | 13.70 | 10.18 | 3 | 97153 | 3 | 50507965 |
Marcus Gunn syndrome | 13.70 | 10.18 | 3 | 97153 | 3 | 50507965 |
Generalised tonic-clonic seizure | 13.68 | 10.18 | 92 | 97064 | 26218 | 50481750 |
Increased appetite | 13.50 | 10.18 | 41 | 97115 | 8320 | 50499648 |
Muscle contracture | 13.50 | 10.18 | 14 | 97142 | 1193 | 50506775 |
Nodule | 13.40 | 10.18 | 8 | 97148 | 16995 | 50490973 |
Tri-iodothyronine free decreased | 13.38 | 10.18 | 8 | 97148 | 302 | 50507666 |
Product use in unapproved indication | 13.34 | 10.18 | 150 | 97006 | 115669 | 50392299 |
Therapeutic product effect incomplete | 13.29 | 10.18 | 112 | 97044 | 91403 | 50416565 |
Glossoptosis | 13.29 | 10.18 | 5 | 97151 | 64 | 50507904 |
Oculogyric crisis | 13.16 | 10.18 | 15 | 97141 | 1422 | 50506546 |
Panic disorder | 13.12 | 10.18 | 19 | 97137 | 2284 | 50505684 |
Resting tremor | 13.12 | 10.18 | 11 | 97145 | 715 | 50507253 |
Device expulsion | 13.05 | 10.18 | 22 | 97134 | 28800 | 50479168 |
Adverse drug reaction | 13.05 | 10.18 | 58 | 97098 | 55164 | 50452804 |
Decreased activity | 13.04 | 10.18 | 30 | 97126 | 5157 | 50502811 |
Poor sucking reflex | 13.02 | 10.18 | 7 | 97149 | 215 | 50507753 |
Oscillopsia | 12.94 | 10.18 | 6 | 97150 | 133 | 50507835 |
Dissociative disorder | 12.93 | 10.18 | 7 | 97149 | 218 | 50507750 |
Suicidal behaviour | 12.93 | 10.18 | 19 | 97137 | 2315 | 50505653 |
Brugada syndrome | 12.92 | 10.18 | 8 | 97148 | 322 | 50507646 |
Rhabdomyolysis | 12.91 | 10.18 | 123 | 97033 | 38904 | 50469064 |
Clostridium difficile infection | 12.88 | 10.18 | 18 | 97138 | 25421 | 50482547 |
Joint range of motion decreased | 12.86 | 10.18 | 10 | 97146 | 18502 | 50489466 |
Infusion site scar | 12.79 | 10.18 | 8 | 97148 | 328 | 50507640 |
Therapy interrupted | 12.65 | 10.18 | 12 | 97144 | 20140 | 50487828 |
Genital labial adhesions | 12.65 | 10.18 | 4 | 97152 | 29 | 50507939 |
Yawning | 12.62 | 10.18 | 12 | 97144 | 921 | 50507047 |
Serum sickness-like reaction | 12.59 | 10.18 | 9 | 97147 | 462 | 50507506 |
Regressive behaviour | 12.57 | 10.18 | 5 | 97151 | 75 | 50507893 |
Aortic stenosis | 12.53 | 10.18 | 26 | 97130 | 4168 | 50503800 |
Colitis microscopic | 12.49 | 10.18 | 34 | 97122 | 6486 | 50501482 |
Congenital neurological disorder | 12.49 | 10.18 | 3 | 97153 | 6 | 50507962 |
Asplenia | 12.49 | 10.18 | 3 | 97153 | 6 | 50507962 |
Aeromonas infection | 12.45 | 10.18 | 5 | 97151 | 77 | 50507891 |
Right aortic arch | 12.40 | 10.18 | 7 | 97149 | 237 | 50507731 |
Delusion of grandeur | 12.40 | 10.18 | 6 | 97150 | 147 | 50507821 |
Blood pressure fluctuation | 12.30 | 10.18 | 32 | 97124 | 35791 | 50472177 |
Apallic syndrome | 12.29 | 10.18 | 10 | 97146 | 623 | 50507345 |
Toxic shock syndrome | 12.23 | 10.18 | 9 | 97147 | 483 | 50507485 |
Spina bifida occulta | 12.17 | 10.18 | 3 | 97153 | 7 | 50507961 |
Laboratory test abnormal | 12.17 | 10.18 | 16 | 97140 | 23192 | 50484776 |
Mouth ulceration | 12.13 | 10.18 | 22 | 97134 | 28002 | 50479966 |
Atrial fibrillation | 12.02 | 10.18 | 131 | 97025 | 101614 | 50406354 |
Haemoglobin decreased | 11.95 | 10.18 | 172 | 96984 | 127044 | 50380924 |
Antiphospholipid antibodies | 11.93 | 10.18 | 6 | 97150 | 160 | 50507808 |
Marital problem | 11.90 | 10.18 | 6 | 97150 | 161 | 50507807 |
Muscle tightness | 11.83 | 10.18 | 45 | 97111 | 10235 | 50497733 |
Septic shock | 11.80 | 10.18 | 63 | 97093 | 57112 | 50450856 |
Intestinal infarction | 11.79 | 10.18 | 12 | 97144 | 1000 | 50506968 |
Skin ulcer | 11.78 | 10.18 | 32 | 97124 | 35286 | 50472682 |
Sexual dysfunction | 11.76 | 10.18 | 22 | 97134 | 3270 | 50504698 |
Premature delivery | 11.72 | 10.18 | 17 | 97139 | 23646 | 50484322 |
Paroxysmal arrhythmia | 11.70 | 10.18 | 4 | 97152 | 38 | 50507930 |
Cholecystitis chronic | 11.69 | 10.18 | 43 | 97113 | 9626 | 50498342 |
Anal atresia | 11.68 | 10.18 | 8 | 97148 | 383 | 50507585 |
Inferior vena caval occlusion | 11.63 | 10.18 | 3 | 97153 | 9 | 50507959 |
Abdominal wall cyst | 11.63 | 10.18 | 3 | 97153 | 9 | 50507959 |
Visual impairment | 11.63 | 10.18 | 190 | 96966 | 68085 | 50439883 |
Hypercapnic coma | 11.57 | 10.18 | 6 | 97150 | 171 | 50507797 |
Posture abnormal | 11.56 | 10.18 | 17 | 97139 | 2072 | 50505896 |
Tenosynovitis | 11.55 | 10.18 | 3 | 97153 | 10562 | 50497406 |
Ear pain | 11.55 | 10.18 | 23 | 97133 | 28260 | 50479708 |
Coronary artery disease | 11.53 | 10.18 | 97 | 97059 | 29629 | 50478339 |
Dermatitis allergic | 11.49 | 10.18 | 5 | 97151 | 12715 | 50495253 |
Pharyngitis | 11.49 | 10.18 | 10 | 97146 | 17493 | 50490475 |
Pneumocystis jirovecii pneumonia | 11.41 | 10.18 | 7 | 97149 | 14656 | 50493312 |
Platelet count decreased | 11.38 | 10.18 | 131 | 97025 | 100595 | 50407373 |
Reversible cerebral vasoconstriction syndrome | 11.38 | 10.18 | 17 | 97139 | 2102 | 50505866 |
Hypoosmolar state | 11.38 | 10.18 | 6 | 97150 | 177 | 50507791 |
Blood aldosterone abnormal | 11.34 | 10.18 | 4 | 97152 | 42 | 50507926 |
Congenital coronary artery malformation | 11.30 | 10.18 | 5 | 97151 | 99 | 50507869 |
Bradykinesia | 11.26 | 10.18 | 24 | 97132 | 3919 | 50504049 |
Double outlet right ventricle | 11.26 | 10.18 | 4 | 97152 | 43 | 50507925 |
Persecutory delusion | 11.21 | 10.18 | 18 | 97138 | 2369 | 50505599 |
Accidental overdose | 11.20 | 10.18 | 70 | 97086 | 19463 | 50488505 |
Liver function test increased | 11.18 | 10.18 | 20 | 97136 | 25586 | 50482382 |
Hyperventilation | 11.17 | 10.18 | 29 | 97127 | 5380 | 50502588 |
Prescription drug used without a prescription | 11.14 | 10.18 | 15 | 97141 | 1685 | 50506283 |
Cystocele | 11.06 | 10.18 | 12 | 97144 | 1077 | 50506891 |
Cataract | 10.98 | 10.18 | 50 | 97106 | 47250 | 50460718 |
Diet refusal | 10.96 | 10.18 | 9 | 97147 | 568 | 50507400 |
Blood cholinesterase decreased | 10.91 | 10.18 | 5 | 97151 | 108 | 50507860 |
Obstructive airways disorder | 10.86 | 10.18 | 59 | 97097 | 15593 | 50492375 |
Hyperthermia | 10.84 | 10.18 | 36 | 97120 | 7660 | 50500308 |
Obesity | 10.82 | 10.18 | 62 | 97094 | 16713 | 50491255 |
Parkinsonian gait | 10.80 | 10.18 | 8 | 97148 | 434 | 50507534 |
Congenital pulmonary valve disorder | 10.72 | 10.18 | 4 | 97152 | 50 | 50507918 |
Respiratory tract infection | 10.69 | 10.18 | 29 | 97127 | 31988 | 50475980 |
Congenital diaphragmatic hernia | 10.50 | 10.18 | 6 | 97150 | 208 | 50507760 |
Anencephaly | 10.50 | 10.18 | 6 | 97150 | 208 | 50507760 |
Left ventricular dysfunction | 10.49 | 10.18 | 44 | 97112 | 10462 | 50497506 |
Stupor | 10.46 | 10.18 | 22 | 97134 | 3561 | 50504407 |
Congenital eye disorder | 10.43 | 10.18 | 3 | 97153 | 15 | 50507953 |
Palmar-plantar erythrodysaesthesia syndrome | 10.40 | 10.18 | 14 | 97142 | 20084 | 50487884 |
Diverticulitis | 10.38 | 10.18 | 31 | 97125 | 33151 | 50474817 |
Mutism | 10.32 | 10.18 | 13 | 97143 | 1368 | 50506600 |
Influenza | 10.29 | 10.18 | 116 | 97040 | 89422 | 50418546 |
Normetanephrine urine increased | 10.27 | 10.18 | 3 | 97153 | 16 | 50507952 |
Hydrocephalus | 10.23 | 10.18 | 26 | 97130 | 4762 | 50503206 |
Transaminases increased | 10.22 | 10.18 | 24 | 97132 | 27800 | 50480168 |
Posturing | 10.20 | 10.18 | 8 | 97148 | 473 | 50507495 |
Housebound | 10.19 | 10.18 | 6 | 97150 | 220 | 50507748 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 1786.34 | 11.01 | 638 | 50167 | 7916 | 29515806 |
Atrial septal defect | 802.54 | 11.01 | 335 | 50470 | 6454 | 29517268 |
Ventricular septal defect | 555.16 | 11.01 | 214 | 50591 | 3315 | 29520407 |
Patent ductus arteriosus | 482.31 | 11.01 | 187 | 50618 | 2944 | 29520778 |
Foetal exposure during pregnancy | 432.45 | 11.01 | 401 | 50404 | 33466 | 29490256 |
Drug withdrawal syndrome | 397.71 | 11.01 | 293 | 50512 | 17691 | 29506031 |
Cardiac murmur | 348.45 | 11.01 | 187 | 50618 | 6426 | 29517296 |
Congenital anomaly | 303.29 | 11.01 | 106 | 50699 | 1222 | 29522500 |
Suicidal ideation | 288.09 | 11.01 | 326 | 50479 | 34390 | 29489332 |
Heart disease congenital | 250.06 | 11.01 | 91 | 50714 | 1189 | 29522533 |
Multiple congenital abnormalities | 248.83 | 11.01 | 73 | 50732 | 451 | 29523271 |
Serotonin syndrome | 246.17 | 11.01 | 219 | 50586 | 17293 | 29506429 |
Pulmonary valve stenosis | 228.78 | 11.01 | 63 | 50742 | 298 | 29523424 |
Anxiety | 221.59 | 11.01 | 467 | 50338 | 84898 | 29438824 |
Talipes | 220.32 | 11.01 | 91 | 50714 | 1701 | 29522021 |
Suicide attempt | 218.60 | 11.01 | 281 | 50524 | 33829 | 29489893 |
Irritability | 206.16 | 11.01 | 221 | 50584 | 21931 | 29501791 |
Aggression | 204.93 | 11.01 | 278 | 50527 | 35263 | 29488459 |
Coarctation of the aorta | 186.61 | 11.01 | 57 | 50748 | 412 | 29523310 |
Persistent foetal circulation | 168.23 | 11.01 | 49 | 50756 | 294 | 29523428 |
Completed suicide | 165.48 | 11.01 | 431 | 50374 | 89815 | 29433907 |
Bicuspid aortic valve | 161.16 | 11.01 | 43 | 50762 | 176 | 29523546 |
Hypoplastic left heart syndrome | 159.26 | 11.01 | 43 | 50762 | 186 | 29523536 |
Pulmonary artery stenosis congenital | 155.48 | 11.01 | 50 | 50755 | 436 | 29523286 |
Fallot's tetralogy | 147.68 | 11.01 | 39 | 50766 | 152 | 29523570 |
Transposition of the great vessels | 125.68 | 11.01 | 42 | 50763 | 418 | 29523304 |
Congenital aortic stenosis | 115.94 | 11.01 | 28 | 50777 | 68 | 29523654 |
Mania | 111.22 | 11.01 | 103 | 50702 | 8560 | 29515162 |
Agitation | 106.46 | 11.01 | 257 | 50548 | 51047 | 29472675 |
Insomnia | 103.90 | 11.01 | 362 | 50443 | 88399 | 29435323 |
Intentional self-injury | 101.52 | 11.01 | 116 | 50689 | 12345 | 29511377 |
Impulsive behaviour | 99.68 | 11.01 | 54 | 50751 | 1889 | 29521833 |
Craniosynostosis | 99.31 | 11.01 | 32 | 50773 | 281 | 29523441 |
Panic attack | 99.24 | 11.01 | 95 | 50710 | 8231 | 29515491 |
Disturbance in attention | 97.69 | 11.01 | 150 | 50655 | 21274 | 29502448 |
Developmental delay | 96.92 | 11.01 | 58 | 50747 | 2460 | 29521262 |
Activation syndrome | 94.97 | 11.01 | 24 | 50781 | 75 | 29523647 |
Tremor | 94.05 | 11.01 | 309 | 50496 | 73229 | 29450493 |
Extrapyramidal disorder | 91.93 | 11.01 | 103 | 50702 | 10728 | 29512994 |
Depression | 90.90 | 11.01 | 337 | 50468 | 84810 | 29438912 |
Febrile neutropenia | 90.13 | 11.01 | 40 | 50765 | 112200 | 29411522 |
Off label use | 89.63 | 11.01 | 245 | 50560 | 300555 | 29223167 |
Congenital cardiovascular anomaly | 82.65 | 11.01 | 25 | 50780 | 174 | 29523548 |
Homicide | 80.96 | 11.01 | 37 | 50768 | 891 | 29522831 |
Neuroleptic malignant syndrome | 79.22 | 11.01 | 117 | 50688 | 16031 | 29507691 |
Sopor | 77.83 | 11.01 | 95 | 50710 | 10839 | 29512883 |
Death | 76.97 | 11.01 | 315 | 50490 | 341769 | 29181953 |
Pneumonia | 76.36 | 11.01 | 288 | 50517 | 319884 | 29203838 |
Intentional overdose | 74.60 | 11.01 | 188 | 50617 | 38340 | 29485382 |
Cleft lip and palate | 74.59 | 11.01 | 26 | 50779 | 297 | 29523425 |
Acute kidney injury | 73.86 | 11.01 | 223 | 50582 | 265044 | 29258678 |
Anger | 73.30 | 11.01 | 92 | 50713 | 10798 | 29512924 |
Sleep disorder | 72.12 | 11.01 | 141 | 50664 | 24245 | 29499477 |
Coma | 69.70 | 11.01 | 186 | 50619 | 39264 | 29484458 |
Withdrawal syndrome | 69.47 | 11.01 | 90 | 50715 | 10902 | 29512820 |
Somnolence | 69.14 | 11.01 | 332 | 50473 | 93623 | 29430099 |
Double outlet right ventricle | 68.12 | 11.01 | 19 | 50786 | 95 | 29523627 |
Drug abuse | 67.48 | 11.01 | 294 | 50511 | 79589 | 29444133 |
Congenital aortic atresia | 64.99 | 11.01 | 14 | 50791 | 15 | 29523707 |
Pulmonary malformation | 59.50 | 11.01 | 14 | 50791 | 29 | 29523693 |
Tricuspid valve incompetence | 58.23 | 11.01 | 72 | 50733 | 8322 | 29515400 |
Hypoplastic right heart syndrome | 57.17 | 11.01 | 12 | 50793 | 10 | 29523712 |
Mood swings | 56.54 | 11.01 | 66 | 50739 | 7185 | 29516537 |
Cleft palate | 56.40 | 11.01 | 25 | 50780 | 559 | 29523163 |
Speech disorder developmental | 55.99 | 11.01 | 37 | 50768 | 1870 | 29521852 |
Inappropriate antidiuretic hormone secretion | 54.76 | 11.01 | 80 | 50725 | 10852 | 29512870 |
Drug ineffective | 52.63 | 11.01 | 387 | 50418 | 362783 | 29160939 |
Sexual dysfunction | 52.29 | 11.01 | 57 | 50748 | 5757 | 29517965 |
Confusional state | 52.10 | 11.01 | 387 | 50418 | 127490 | 29396232 |
Hyperhidrosis | 51.81 | 11.01 | 234 | 50571 | 64306 | 29459416 |
Poisoning deliberate | 51.22 | 11.01 | 56 | 50749 | 5675 | 29518047 |
Drug withdrawal syndrome neonatal | 50.76 | 11.01 | 44 | 50761 | 3351 | 29520371 |
Sepsis | 50.44 | 11.01 | 106 | 50699 | 142576 | 29381146 |
Nervousness | 49.90 | 11.01 | 78 | 50727 | 11228 | 29512494 |
Pulmonary valve stenosis congenital | 47.35 | 11.01 | 15 | 50790 | 124 | 29523598 |
Plagiocephaly | 46.91 | 11.01 | 21 | 50784 | 481 | 29523241 |
Dyspnoea | 46.90 | 11.01 | 349 | 50456 | 326383 | 29197339 |
Hamartoma | 46.01 | 11.01 | 12 | 50793 | 44 | 29523678 |
Diarrhoea | 45.58 | 11.01 | 360 | 50445 | 332338 | 29191384 |
Congenital aortic valve incompetence | 45.46 | 11.01 | 15 | 50790 | 143 | 29523579 |
Arnold-Chiari malformation | 45.35 | 11.01 | 18 | 50787 | 302 | 29523420 |
Thrombocytopenia | 44.50 | 11.01 | 104 | 50701 | 134719 | 29389003 |
Gun shot wound | 44.39 | 11.01 | 26 | 50779 | 1059 | 29522663 |
Nightmare | 43.91 | 11.01 | 74 | 50731 | 11343 | 29512379 |
Depressed mood | 43.73 | 11.01 | 91 | 50714 | 16357 | 29507365 |
Visceral congestion | 43.52 | 11.01 | 20 | 50785 | 488 | 29523234 |
Erectile dysfunction | 42.56 | 11.01 | 95 | 50710 | 17914 | 29505808 |
Overdose | 42.35 | 11.01 | 258 | 50547 | 79561 | 29444161 |
Ventricular hypoplasia | 42.23 | 11.01 | 12 | 50793 | 65 | 29523657 |
Attention deficit hyperactivity disorder | 42.07 | 11.01 | 33 | 50772 | 2184 | 29521538 |
Anaemia | 41.99 | 11.01 | 190 | 50615 | 200761 | 29322961 |
Maternal drugs affecting foetus | 41.87 | 11.01 | 42 | 50763 | 3851 | 29519871 |
Anticholinergic syndrome | 40.79 | 11.01 | 23 | 50782 | 871 | 29522851 |
Hyperreflexia | 39.59 | 11.01 | 35 | 50770 | 2737 | 29520985 |
Right aortic arch | 39.52 | 11.01 | 9 | 50796 | 15 | 29523707 |
Tremor neonatal | 39.51 | 11.01 | 17 | 50788 | 353 | 29523369 |
Hangover | 38.89 | 11.01 | 23 | 50782 | 954 | 29522768 |
Pyrexia | 38.53 | 11.01 | 313 | 50492 | 287309 | 29236413 |
Right ventricular hypertrophy | 37.70 | 11.01 | 24 | 50781 | 1137 | 29522585 |
Akathisia | 37.69 | 11.01 | 52 | 50753 | 6690 | 29517032 |
Congenital tricuspid valve atresia | 37.69 | 11.01 | 12 | 50793 | 101 | 29523621 |
Restlessness | 37.68 | 11.01 | 103 | 50702 | 22042 | 29501680 |
Mitral valve stenosis | 36.62 | 11.01 | 15 | 50790 | 274 | 29523448 |
Rash | 36.42 | 11.01 | 185 | 50620 | 189634 | 29334088 |
Cogwheel rigidity | 36.21 | 11.01 | 24 | 50781 | 1219 | 29522503 |
Malignant neoplasm progression | 35.30 | 11.01 | 45 | 50760 | 73814 | 29449908 |
Disease progression | 35.07 | 11.01 | 54 | 50751 | 81862 | 29441860 |
Feeling of despair | 34.87 | 11.01 | 21 | 50784 | 901 | 29522821 |
Memory impairment | 34.48 | 11.01 | 139 | 50666 | 36331 | 29487391 |
Bipolar disorder | 34.43 | 11.01 | 35 | 50770 | 3260 | 29520462 |
Amnesia | 34.31 | 11.01 | 101 | 50704 | 22542 | 29501180 |
Somnolence neonatal | 34.19 | 11.01 | 8 | 50797 | 16 | 29523706 |
Head titubation | 33.16 | 11.01 | 14 | 50791 | 277 | 29523445 |
Abnormal behaviour | 33.00 | 11.01 | 101 | 50704 | 23026 | 29500696 |
Congenital scoliosis | 32.30 | 11.01 | 10 | 50795 | 76 | 29523646 |
Neutropenia | 32.22 | 11.01 | 117 | 50688 | 131594 | 29392128 |
DiGeorge's syndrome | 32.21 | 11.01 | 6 | 50799 | 0 | 29523722 |
Interruption of aortic arch | 32.21 | 11.01 | 6 | 50799 | 0 | 29523722 |
Agoraphobia | 32.17 | 11.01 | 13 | 50792 | 229 | 29523493 |
Hypomania | 32.14 | 11.01 | 28 | 50777 | 2147 | 29521575 |
Oral discharge | 32.01 | 11.01 | 11 | 50794 | 120 | 29523602 |
Congenital aortic anomaly | 31.96 | 11.01 | 10 | 50795 | 79 | 29523643 |
Parkinsonism | 31.82 | 11.01 | 50 | 50755 | 7228 | 29516494 |
Choanal atresia | 31.81 | 11.01 | 7 | 50798 | 9 | 29523713 |
Hypospadias | 31.58 | 11.01 | 32 | 50773 | 2970 | 29520752 |
Anencephaly | 31.37 | 11.01 | 11 | 50794 | 128 | 29523594 |
Atrial fibrillation | 31.35 | 11.01 | 86 | 50719 | 105560 | 29418162 |
Hyperthermia | 30.93 | 11.01 | 57 | 50748 | 9373 | 29514349 |
Abdominal pain | 30.68 | 11.01 | 124 | 50681 | 135233 | 29388489 |
Congenital pulmonary artery anomaly | 30.61 | 11.01 | 7 | 50798 | 12 | 29523710 |
Homicidal ideation | 30.45 | 11.01 | 29 | 50776 | 2495 | 29521227 |
Libido decreased | 30.02 | 11.01 | 37 | 50768 | 4261 | 29519461 |
Paraesthesia | 29.79 | 11.01 | 176 | 50629 | 53669 | 29470053 |
Infection | 29.70 | 11.01 | 54 | 50751 | 76697 | 29447025 |
Drug dependence | 29.35 | 11.01 | 91 | 50714 | 20890 | 29502832 |
Pancytopenia | 29.18 | 11.01 | 62 | 50743 | 83106 | 29440616 |
Ejaculation delayed | 29.01 | 11.01 | 12 | 50793 | 225 | 29523497 |
Dextrocardia | 28.94 | 11.01 | 10 | 50795 | 111 | 29523611 |
Vertigo | 28.92 | 11.01 | 93 | 50712 | 21768 | 29501954 |
Thinking abnormal | 28.69 | 11.01 | 40 | 50765 | 5196 | 29518526 |
Congenital coronary artery malformation | 28.68 | 11.01 | 8 | 50797 | 40 | 29523682 |
Epistaxis | 28.53 | 11.01 | 28 | 50777 | 51676 | 29472046 |
Verbal abuse | 28.48 | 11.01 | 11 | 50794 | 171 | 29523551 |
Mydriasis | 28.28 | 11.01 | 43 | 50762 | 6042 | 29517680 |
Renal impairment | 28.23 | 11.01 | 61 | 50744 | 81272 | 29442450 |
Tearfulness | 28.16 | 11.01 | 23 | 50782 | 1613 | 29522109 |
Cough | 28.15 | 11.01 | 117 | 50688 | 126610 | 29397112 |
Altered state of consciousness | 27.58 | 11.01 | 86 | 50719 | 19803 | 29503919 |
Congenital genitourinary abnormality | 27.32 | 11.01 | 8 | 50797 | 49 | 29523673 |
Intentional product use issue | 27.14 | 11.01 | 20 | 50785 | 42478 | 29481244 |
Emotional distress | 27.08 | 11.01 | 68 | 50737 | 13827 | 29509895 |
Physical assault | 27.00 | 11.01 | 19 | 50786 | 1065 | 29522657 |
Congenital mitral valve stenosis | 26.84 | 11.01 | 5 | 50800 | 0 | 29523722 |
Ebstein's anomaly | 26.84 | 11.01 | 5 | 50800 | 0 | 29523722 |
Cytomegalovirus infection | 26.70 | 11.01 | 4 | 50801 | 23211 | 29500511 |
Paranoia | 26.66 | 11.01 | 55 | 50750 | 9822 | 29513900 |
Developmental hip dysplasia | 26.64 | 11.01 | 12 | 50793 | 279 | 29523443 |
Hyper IgE syndrome | 26.53 | 11.01 | 8 | 50797 | 55 | 29523667 |
Muscle rigidity | 26.11 | 11.01 | 53 | 50752 | 9358 | 29514364 |
Pulmonary valve incompetence | 26.06 | 11.01 | 16 | 50789 | 711 | 29523011 |
Product use issue | 26.00 | 11.01 | 30 | 50775 | 51414 | 29472308 |
Multiple cardiac defects | 25.82 | 11.01 | 8 | 50797 | 61 | 29523661 |
Selective eating disorder | 25.77 | 11.01 | 22 | 50783 | 1641 | 29522081 |
Autism spectrum disorder | 25.77 | 11.01 | 24 | 50781 | 2008 | 29521714 |
Pulmonary artery stenosis | 25.76 | 11.01 | 11 | 50794 | 224 | 29523498 |
Cleft lip | 25.34 | 11.01 | 12 | 50793 | 314 | 29523408 |
Bronchopulmonary dysplasia | 25.32 | 11.01 | 14 | 50791 | 510 | 29523212 |
Ejaculation failure | 25.27 | 11.01 | 16 | 50789 | 751 | 29522971 |
Drug abuser | 25.22 | 11.01 | 32 | 50773 | 3795 | 29519927 |
Blepharospasm | 25.14 | 11.01 | 18 | 50787 | 1037 | 29522685 |
Vascular stenosis | 24.97 | 11.01 | 10 | 50795 | 172 | 29523550 |
Emotional disorder | 24.57 | 11.01 | 36 | 50769 | 4895 | 29518827 |
Reversible cerebral vasoconstriction syndrome | 24.33 | 11.01 | 11 | 50794 | 258 | 29523464 |
Aortic valve incompetence | 24.11 | 11.01 | 36 | 50769 | 4977 | 29518745 |
Treatment failure | 24.09 | 11.01 | 17 | 50788 | 36922 | 29486800 |
Congenital hand malformation | 23.97 | 11.01 | 14 | 50791 | 567 | 29523155 |
Neural tube defect | 23.75 | 11.01 | 7 | 50798 | 44 | 29523678 |
Congenital pulmonary hypertension | 23.62 | 11.01 | 7 | 50798 | 45 | 29523677 |
Neonatal asphyxia | 23.47 | 11.01 | 11 | 50794 | 281 | 29523441 |
General physical health deterioration | 23.44 | 11.01 | 94 | 50711 | 102763 | 29420959 |
Septic shock | 23.33 | 11.01 | 45 | 50760 | 62515 | 29461207 |
C-reactive protein increased | 23.26 | 11.01 | 25 | 50780 | 44238 | 29479484 |
Congenital tracheomalacia | 22.91 | 11.01 | 5 | 50800 | 6 | 29523716 |
Psychotic disorder | 22.88 | 11.01 | 82 | 50723 | 20272 | 29503450 |
Seizure | 22.57 | 11.01 | 252 | 50553 | 92871 | 29430851 |
Cardiomegaly | 22.37 | 11.01 | 63 | 50742 | 13713 | 29510009 |
Truncus arteriosus persistent | 22.21 | 11.01 | 6 | 50799 | 26 | 29523696 |
Hallucination, auditory | 21.99 | 11.01 | 50 | 50755 | 9543 | 29514179 |
Hospitalisation | 21.98 | 11.01 | 28 | 50777 | 45960 | 29477762 |
Joint swelling | 21.93 | 11.01 | 32 | 50773 | 49598 | 29474124 |
Depressed level of consciousness | 21.89 | 11.01 | 123 | 50682 | 36819 | 29486903 |
Gastroschisis | 21.88 | 11.01 | 8 | 50797 | 106 | 29523616 |
Mood altered | 21.70 | 11.01 | 45 | 50760 | 8066 | 29515656 |
Haemoglobin decreased | 21.68 | 11.01 | 104 | 50701 | 108271 | 29415451 |
Logorrhoea | 21.57 | 11.01 | 23 | 50782 | 2265 | 29521457 |
Congenital hydronephrosis | 21.52 | 11.01 | 14 | 50791 | 689 | 29523033 |
Mitral valve atresia | 21.47 | 11.01 | 4 | 50801 | 0 | 29523722 |
Noonan syndrome | 21.47 | 11.01 | 4 | 50801 | 0 | 29523722 |
Porencephaly | 21.47 | 11.01 | 4 | 50801 | 0 | 29523722 |
Abdominal transposition | 21.47 | 11.01 | 4 | 50801 | 0 | 29523722 |
Idiosyncratic alcohol intoxication | 21.47 | 11.01 | 4 | 50801 | 0 | 29523722 |
Hepatic enzyme increased | 21.46 | 11.01 | 16 | 50789 | 33783 | 29489939 |
Spina bifida | 21.46 | 11.01 | 11 | 50794 | 343 | 29523379 |
Erythema | 21.35 | 11.01 | 63 | 50742 | 75543 | 29448179 |
Platelet count decreased | 21.20 | 11.01 | 100 | 50705 | 104572 | 29419150 |
Chemical submission | 21.19 | 11.01 | 6 | 50799 | 32 | 29523690 |
Congenital diaphragmatic hernia | 21.17 | 11.01 | 10 | 50795 | 260 | 29523462 |
Infantile apnoea | 20.86 | 11.01 | 15 | 50790 | 870 | 29522852 |
Respiratory acidosis | 20.70 | 11.01 | 31 | 50774 | 4297 | 29519425 |
Product use in unapproved indication | 20.68 | 11.01 | 78 | 50727 | 86797 | 29436925 |
Agitation neonatal | 20.65 | 11.01 | 16 | 50789 | 1040 | 29522682 |
Wolff-Parkinson-White syndrome | 20.52 | 11.01 | 9 | 50796 | 196 | 29523526 |
Self esteem decreased | 20.13 | 11.01 | 12 | 50793 | 505 | 29523217 |
Toxicity to various agents | 20.12 | 11.01 | 414 | 50391 | 173247 | 29350475 |
Tonic convulsion | 20.11 | 11.01 | 15 | 50790 | 921 | 29522801 |
Blood creatine phosphokinase increased | 20.05 | 11.01 | 129 | 50676 | 40515 | 29483207 |
Flat affect | 20.00 | 11.01 | 14 | 50791 | 778 | 29522944 |
Bradykinesia | 19.89 | 11.01 | 27 | 50778 | 3420 | 29520302 |
Sleep apnoea syndrome | 19.87 | 11.01 | 71 | 50734 | 17528 | 29506194 |
Premature baby | 19.75 | 11.01 | 70 | 50735 | 17210 | 29506512 |
Somatic dysfunction | 19.69 | 11.01 | 5 | 50800 | 16 | 29523706 |
Ventricular hypertrophy | 19.63 | 11.01 | 30 | 50775 | 4234 | 29519488 |
Congenital hydrocephalus | 19.48 | 11.01 | 7 | 50798 | 88 | 29523634 |
Tension | 19.41 | 11.01 | 20 | 50785 | 1893 | 29521829 |
Decreased interest | 19.29 | 11.01 | 21 | 50784 | 2117 | 29521605 |
Congenital flat feet | 19.24 | 11.01 | 4 | 50801 | 3 | 29523719 |
Pneumocystis jirovecii pneumonia | 19.04 | 11.01 | 3 | 50802 | 16776 | 29506946 |
Cardiac failure | 18.99 | 11.01 | 71 | 50734 | 79216 | 29444506 |
Derealisation | 18.88 | 11.01 | 12 | 50793 | 567 | 29523155 |
Peripheral swelling | 18.81 | 11.01 | 52 | 50753 | 63687 | 29460035 |
Cerebrovascular stenosis | 18.73 | 11.01 | 7 | 50798 | 99 | 29523623 |
Right ventricle outflow tract obstruction | 18.71 | 11.01 | 4 | 50801 | 4 | 29523718 |
Infantile back arching | 18.71 | 11.01 | 4 | 50801 | 4 | 29523718 |
Affect lability | 18.66 | 11.01 | 26 | 50779 | 3376 | 29520346 |
Disorientation | 18.65 | 11.01 | 100 | 50705 | 29415 | 29494307 |
Gastrointestinal haemorrhage | 18.55 | 11.01 | 72 | 50733 | 79461 | 29444261 |
Psychiatric symptom | 18.47 | 11.01 | 25 | 50780 | 3159 | 29520563 |
Scaphocephaly | 18.45 | 11.01 | 5 | 50800 | 22 | 29523700 |
Transient tachypnoea of the newborn | 18.42 | 11.01 | 8 | 50797 | 170 | 29523552 |
Crying | 18.38 | 11.01 | 33 | 50772 | 5318 | 29518404 |
Hypotension | 18.26 | 11.01 | 230 | 50575 | 194124 | 29329598 |
Dysmorphism | 18.26 | 11.01 | 24 | 50781 | 2947 | 29520775 |
COVID-19 | 18.19 | 11.01 | 21 | 50784 | 35993 | 29487729 |
Euphoric mood | 18.19 | 11.01 | 31 | 50774 | 4794 | 29518928 |
Type 2 diabetes mellitus | 18.16 | 11.01 | 58 | 50747 | 13523 | 29510199 |
Renal dysplasia | 18.12 | 11.01 | 8 | 50797 | 177 | 29523545 |
Drug reaction with eosinophilia and systemic symptoms | 18.09 | 11.01 | 13 | 50792 | 27979 | 29495743 |
Obsessive thoughts | 18.09 | 11.01 | 12 | 50793 | 610 | 29523112 |
Ascites | 17.81 | 11.01 | 22 | 50783 | 36597 | 29487125 |
Chordee | 17.75 | 11.01 | 6 | 50799 | 62 | 29523660 |
Renal failure | 17.73 | 11.01 | 125 | 50680 | 118474 | 29405248 |
Abulia | 17.69 | 11.01 | 11 | 50794 | 500 | 29523222 |
Oedema peripheral | 17.59 | 11.01 | 105 | 50700 | 103452 | 29420270 |
Maternal exposure during pregnancy | 17.57 | 11.01 | 28 | 50777 | 4095 | 29519627 |
Caesarean section | 17.55 | 11.01 | 19 | 50786 | 1904 | 29521818 |
Ejaculation disorder | 17.49 | 11.01 | 14 | 50791 | 954 | 29522768 |
Neutrophil count decreased | 17.44 | 11.01 | 30 | 50775 | 43537 | 29480185 |
Congenital renal disorder | 17.42 | 11.01 | 6 | 50799 | 66 | 29523656 |
Aortic stenosis | 17.37 | 11.01 | 27 | 50778 | 3867 | 29519855 |
Hypersensitivity | 17.27 | 11.01 | 41 | 50764 | 52862 | 29470860 |
Ammonia abnormal | 17.25 | 11.01 | 6 | 50799 | 68 | 29523654 |
Myoclonus | 17.04 | 11.01 | 56 | 50749 | 13253 | 29510469 |
Dyskinesia | 17.03 | 11.01 | 74 | 50731 | 19987 | 29503735 |
Abnormal dreams | 16.90 | 11.01 | 37 | 50768 | 6883 | 29516839 |
Tricuspid valve disease | 16.90 | 11.01 | 8 | 50797 | 209 | 29523513 |
Pulmonary hypoplasia | 16.88 | 11.01 | 10 | 50795 | 416 | 29523306 |
Alcohol interaction | 16.87 | 11.01 | 22 | 50783 | 2681 | 29521041 |
Infusion related reaction | 16.86 | 11.01 | 31 | 50774 | 43855 | 29479867 |
Hyperkinesia | 16.74 | 11.01 | 17 | 50788 | 1582 | 29522140 |
White blood cell count decreased | 16.66 | 11.01 | 80 | 50725 | 83282 | 29440440 |
Pleurothotonus | 16.63 | 11.01 | 14 | 50791 | 1024 | 29522698 |
Urinary tract infection | 16.55 | 11.01 | 66 | 50739 | 72288 | 29451434 |
Speech disorder | 16.47 | 11.01 | 82 | 50723 | 23434 | 29500288 |
Neurosis | 16.46 | 11.01 | 7 | 50798 | 141 | 29523581 |
Mucosal inflammation | 16.42 | 11.01 | 18 | 50787 | 31577 | 29492145 |
Hypertonia | 16.32 | 11.01 | 26 | 50779 | 3803 | 29519919 |
Leukopenia | 16.31 | 11.01 | 45 | 50760 | 55158 | 29468564 |
Opisthotonus | 16.29 | 11.01 | 10 | 50795 | 444 | 29523278 |
Jaundice neonatal | 16.25 | 11.01 | 15 | 50790 | 1241 | 29522481 |
Dystonia | 16.23 | 11.01 | 45 | 50760 | 9704 | 29514018 |
Judgement impaired | 16.21 | 11.01 | 11 | 50794 | 581 | 29523141 |
Cyclothymic disorder | 16.11 | 11.01 | 6 | 50799 | 84 | 29523638 |
Congenital pulmonary valve disorder | 16.11 | 11.01 | 3 | 50802 | 0 | 29523722 |
Congenital Eustachian tube anomaly | 16.11 | 11.01 | 3 | 50802 | 0 | 29523722 |
Vesicoureteric reflux | 16.07 | 11.01 | 7 | 50798 | 150 | 29523572 |
Asphyxia | 16.03 | 11.01 | 31 | 50774 | 5284 | 29518438 |
Clumsiness | 15.74 | 11.01 | 16 | 50789 | 1490 | 29522232 |
Exomphalos | 15.73 | 11.01 | 7 | 50798 | 158 | 29523564 |
Vasoplegia syndrome | 15.72 | 11.01 | 16 | 50789 | 1492 | 29522230 |
Cryptorchism | 15.68 | 11.01 | 18 | 50787 | 1924 | 29521798 |
Personality disorder | 15.68 | 11.01 | 14 | 50791 | 1109 | 29522613 |
Inadequate analgesia | 15.64 | 11.01 | 21 | 50784 | 2633 | 29521089 |
Dissociation | 15.61 | 11.01 | 14 | 50791 | 1115 | 29522607 |
Contraindicated product administered | 15.46 | 11.01 | 6 | 50799 | 18260 | 29505462 |
Obsessive-compulsive disorder | 15.43 | 11.01 | 28 | 50777 | 4548 | 29519174 |
Drug intolerance | 15.39 | 11.01 | 38 | 50767 | 48341 | 29475381 |
Plasma cell myeloma | 15.37 | 11.01 | 25 | 50780 | 37090 | 29486632 |
Mitral valve incompetence | 15.32 | 11.01 | 54 | 50751 | 13239 | 29510483 |
Renal salt-wasting syndrome | 15.22 | 11.01 | 7 | 50798 | 171 | 29523551 |
Cerebral palsy | 15.15 | 11.01 | 6 | 50799 | 100 | 29523622 |
Legal problem | 15.15 | 11.01 | 7 | 50798 | 173 | 29523549 |
Lower respiratory tract infection | 15.03 | 11.01 | 14 | 50791 | 26488 | 29497234 |
Rebound effect | 15.03 | 11.01 | 18 | 50787 | 2013 | 29521709 |
Panic disorder | 14.98 | 11.01 | 14 | 50791 | 1176 | 29522546 |
Infertility male | 14.93 | 11.01 | 7 | 50798 | 179 | 29523543 |
Epilepsy | 14.89 | 11.01 | 67 | 50738 | 18365 | 29505357 |
Phimosis | 14.74 | 11.01 | 11 | 50794 | 676 | 29523046 |
Chronic kidney disease | 14.64 | 11.01 | 25 | 50780 | 36391 | 29487331 |
Congenital mitral valve incompetence | 14.58 | 11.01 | 6 | 50799 | 111 | 29523611 |
Feeling jittery | 14.57 | 11.01 | 24 | 50781 | 3609 | 29520113 |
Ankyloglossia congenital | 14.53 | 11.01 | 8 | 50797 | 289 | 29523433 |
Feeling abnormal | 14.42 | 11.01 | 150 | 50655 | 54295 | 29469427 |
Neoplasm progression | 14.35 | 11.01 | 7 | 50798 | 18605 | 29505117 |
Thrombosis | 14.34 | 11.01 | 33 | 50772 | 43012 | 29480710 |
Arthralgia | 14.34 | 11.01 | 162 | 50643 | 139455 | 29384267 |
Neuropathy peripheral | 14.29 | 11.01 | 68 | 50737 | 70959 | 29452763 |
Haemoptysis | 14.19 | 11.01 | 19 | 50786 | 30531 | 29493191 |
Delusion | 14.19 | 11.01 | 47 | 50758 | 11169 | 29512553 |
Mitral valve prolapse | 14.19 | 11.01 | 10 | 50795 | 562 | 29523160 |
Multiple organ dysfunction syndrome | 14.16 | 11.01 | 58 | 50747 | 63058 | 29460664 |
Brachycephaly | 14.12 | 11.01 | 5 | 50800 | 60 | 29523662 |
Jealous delusion | 14.12 | 11.01 | 7 | 50798 | 203 | 29523519 |
Plasmodium vivax infection | 14.03 | 11.01 | 3 | 50802 | 3 | 29523719 |
Oculoauriculovertebral dysplasia | 14.03 | 11.01 | 3 | 50802 | 3 | 29523719 |
Feeling guilty | 13.97 | 11.01 | 8 | 50797 | 312 | 29523410 |
Pyloric stenosis | 13.88 | 11.01 | 11 | 50794 | 739 | 29522983 |
Device breakage | 13.88 | 11.01 | 16 | 50789 | 1718 | 29522004 |
Hyponatraemia | 13.73 | 11.01 | 177 | 50628 | 67456 | 29456266 |
Poisoning | 13.66 | 11.01 | 43 | 50762 | 9950 | 29513772 |
Major depression | 13.62 | 11.01 | 24 | 50781 | 3811 | 29519911 |
VACTERL syndrome | 13.57 | 11.01 | 3 | 50802 | 4 | 29523718 |
Resting tremor | 13.51 | 11.01 | 10 | 50795 | 607 | 29523115 |
Sexually transmitted disease | 13.46 | 11.01 | 4 | 50801 | 26 | 29523696 |
Pruritus | 13.45 | 11.01 | 132 | 50673 | 116717 | 29407005 |
Otitis media chronic | 13.42 | 11.01 | 5 | 50800 | 70 | 29523652 |
Product complaint | 13.32 | 11.01 | 29 | 50776 | 5376 | 29518346 |
Congenital tricuspid valve incompetence | 13.11 | 11.01 | 6 | 50799 | 145 | 29523577 |
Apnoea | 13.10 | 11.01 | 31 | 50774 | 6071 | 29517651 |
Anomalous pulmonary venous connection | 13.05 | 11.01 | 5 | 50800 | 76 | 29523646 |
Cytogenetic abnormality | 13.03 | 11.01 | 11 | 50794 | 808 | 29522914 |
Affective disorder | 13.01 | 11.01 | 21 | 50784 | 3105 | 29520617 |
Colitis | 12.98 | 11.01 | 21 | 50784 | 31227 | 29492495 |
Anaphylactic reaction | 12.96 | 11.01 | 17 | 50788 | 27556 | 29496166 |
Mitral valve disease | 12.91 | 11.01 | 13 | 50792 | 1197 | 29522525 |
Hyperventilation | 12.88 | 11.01 | 18 | 50787 | 2344 | 29521378 |
Asplenia | 12.87 | 11.01 | 5 | 50800 | 79 | 29523643 |
Pulmonary aplasia | 12.82 | 11.01 | 3 | 50802 | 6 | 29523716 |
Thought insertion | 12.82 | 11.01 | 3 | 50802 | 6 | 29523716 |
Bone marrow failure | 12.82 | 11.01 | 17 | 50788 | 27432 | 29496290 |
Drug-induced liver injury | 12.80 | 11.01 | 11 | 50794 | 21644 | 29502078 |
Patient uncooperative | 12.78 | 11.01 | 8 | 50797 | 368 | 29523354 |
Impulse-control disorder | 12.78 | 11.01 | 13 | 50792 | 1212 | 29522510 |
Personality change | 12.72 | 11.01 | 26 | 50779 | 4612 | 29519110 |
Tardive dyskinesia | 12.71 | 11.01 | 28 | 50777 | 5230 | 29518492 |
Administration related reaction | 12.70 | 11.01 | 5 | 50800 | 82 | 29523640 |
Eating disorder | 12.61 | 11.01 | 34 | 50771 | 7213 | 29516509 |
Weight gain poor | 12.57 | 11.01 | 11 | 50794 | 848 | 29522874 |
Atrioventricular septal defect | 12.53 | 11.01 | 6 | 50799 | 161 | 29523561 |
Periventricular leukomalacia | 12.53 | 11.01 | 4 | 50801 | 34 | 29523688 |
Incoherent | 12.50 | 11.01 | 24 | 50781 | 4068 | 29519654 |
Drug screen positive | 12.49 | 11.01 | 23 | 50782 | 3778 | 29519944 |
Aorta hypoplasia | 12.48 | 11.01 | 5 | 50800 | 86 | 29523636 |
Abdominal distension | 12.42 | 11.01 | 39 | 50766 | 45872 | 29477850 |
Hydrocele | 12.35 | 11.01 | 16 | 50789 | 1937 | 29521785 |
Failure to thrive | 12.33 | 11.01 | 35 | 50770 | 7649 | 29516073 |
Hypertonia neonatal | 12.33 | 11.01 | 8 | 50797 | 392 | 29523330 |
Subgaleal haematoma | 12.33 | 11.01 | 4 | 50801 | 36 | 29523686 |
Product administration error | 12.31 | 11.01 | 53 | 50752 | 14257 | 29509465 |
Loss of consciousness | 12.29 | 11.01 | 187 | 50618 | 73869 | 29449853 |
Sedation complication | 12.28 | 11.01 | 13 | 50792 | 1269 | 29522453 |
Palmar-plantar erythrodysaesthesia syndrome | 12.24 | 11.01 | 5 | 50800 | 14754 | 29508968 |
Feeling of relaxation | 12.23 | 11.01 | 4 | 50801 | 37 | 29523685 |
Limb asymmetry | 12.22 | 11.01 | 5 | 50800 | 91 | 29523631 |
Eyelid ptosis congenital | 12.17 | 11.01 | 5 | 50800 | 92 | 29523630 |
Basal cell carcinoma | 12.09 | 11.01 | 7 | 50798 | 16903 | 29506819 |
Blood creatinine increased | 12.08 | 11.01 | 91 | 50714 | 85011 | 29438711 |
Tinnitus | 12.05 | 11.01 | 56 | 50749 | 15558 | 29508164 |
Hepatotoxicity | 11.94 | 11.01 | 8 | 50797 | 17859 | 29505863 |
Device related infection | 11.87 | 11.01 | 6 | 50799 | 15630 | 29508092 |
Persistent depressive disorder | 11.86 | 11.01 | 7 | 50798 | 289 | 29523433 |
Therapeutic response decreased | 11.85 | 11.01 | 15 | 50790 | 24696 | 29499026 |
Dehydration | 11.83 | 11.01 | 133 | 50672 | 114615 | 29409107 |
Haematochezia | 11.80 | 11.01 | 29 | 50776 | 36954 | 29486768 |
Depersonalisation/derealisation disorder | 11.79 | 11.01 | 9 | 50796 | 572 | 29523150 |
Microcephaly | 11.78 | 11.01 | 10 | 50795 | 740 | 29522982 |
Herpes zoster | 11.75 | 11.01 | 21 | 50784 | 30031 | 29493691 |
Duodenal atresia | 11.72 | 11.01 | 3 | 50802 | 10 | 29523712 |
Circulatory collapse | 11.64 | 11.01 | 9 | 50796 | 18664 | 29505058 |
Suspiciousness | 11.63 | 11.01 | 7 | 50798 | 300 | 29523422 |
Hypocalcaemia | 11.62 | 11.01 | 11 | 50794 | 20654 | 29503068 |
Exhibitionism | 11.61 | 11.01 | 4 | 50801 | 44 | 29523678 |
Decerebrate posture | 11.61 | 11.01 | 4 | 50801 | 44 | 29523678 |
Ventricular tachycardia | 11.58 | 11.01 | 13 | 50792 | 22561 | 29501161 |
Divorced | 11.50 | 11.01 | 3 | 50802 | 11 | 29523711 |
Syndactyly | 11.50 | 11.01 | 10 | 50795 | 765 | 29522957 |
Hepatocellular injury | 11.46 | 11.01 | 69 | 50736 | 21174 | 29502548 |
Anorgasmia | 11.44 | 11.01 | 9 | 50796 | 598 | 29523124 |
Hemivertebra | 11.44 | 11.01 | 5 | 50800 | 108 | 29523614 |
Neutropenic sepsis | 11.44 | 11.01 | 3 | 50802 | 11724 | 29511998 |
Cognitive disorder | 11.23 | 11.01 | 74 | 50731 | 23425 | 29500297 |
Intention tremor | 11.22 | 11.01 | 7 | 50798 | 320 | 29523402 |
Neonatal disorder | 11.19 | 11.01 | 10 | 50795 | 793 | 29522929 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 779.33 | 10.09 | 602 | 111208 | 38680 | 64348242 |
Drug withdrawal syndrome | 737.91 | 10.09 | 532 | 111278 | 30759 | 64356163 |
Suicidal ideation | 559.52 | 10.09 | 632 | 111178 | 65910 | 64321012 |
Suicide attempt | 454.00 | 10.09 | 587 | 111223 | 70420 | 64316502 |
Sopor | 421.99 | 10.09 | 375 | 111435 | 29286 | 64357636 |
Anxiety | 413.07 | 10.09 | 1013 | 110797 | 201636 | 64185286 |
Drug abuse | 351.22 | 10.09 | 735 | 111075 | 131639 | 64255283 |
Tremor | 297.55 | 10.09 | 737 | 111073 | 147493 | 64239429 |
Agitation | 292.95 | 10.09 | 539 | 111271 | 87828 | 64299094 |
Completed suicide | 261.30 | 10.09 | 919 | 110891 | 223495 | 64163427 |
Irritability | 254.08 | 10.09 | 316 | 111494 | 36430 | 64350492 |
Intentional self-injury | 247.59 | 10.09 | 278 | 111532 | 28766 | 64358156 |
Somnolence | 247.51 | 10.09 | 846 | 110964 | 202799 | 64184123 |
Mania | 227.81 | 10.09 | 204 | 111606 | 16082 | 64370840 |
Mydriasis | 226.55 | 10.09 | 198 | 111612 | 15114 | 64371808 |
Aggression | 209.01 | 10.09 | 324 | 111486 | 45908 | 64341014 |
Nightmare | 199.89 | 10.09 | 213 | 111597 | 20780 | 64366142 |
Depression | 194.06 | 10.09 | 728 | 111082 | 182563 | 64204359 |
Confusional state | 191.84 | 10.09 | 928 | 110882 | 260216 | 64126706 |
Disturbance in attention | 187.27 | 10.09 | 289 | 111521 | 40785 | 64346137 |
Neuroleptic malignant syndrome | 182.55 | 10.09 | 221 | 111589 | 24775 | 64362147 |
Panic attack | 175.91 | 10.09 | 199 | 111611 | 20754 | 64366168 |
Off label use | 173.52 | 10.09 | 543 | 111267 | 632263 | 63754659 |
Depersonalisation/derealisation disorder | 160.33 | 10.09 | 71 | 111739 | 1569 | 64385353 |
Drug interaction | 159.07 | 10.09 | 1123 | 110687 | 360960 | 64025962 |
Hyponatraemia | 154.30 | 10.09 | 586 | 111224 | 147753 | 64239169 |
Derealisation | 153.52 | 10.09 | 67 | 111743 | 1428 | 64385494 |
Activation syndrome | 151.70 | 10.09 | 43 | 111767 | 228 | 64386694 |
Mood swings | 145.11 | 10.09 | 165 | 111645 | 17303 | 64369619 |
Inappropriate antidiuretic hormone secretion | 143.46 | 10.09 | 185 | 111625 | 22104 | 64364818 |
Disorientation | 142.08 | 10.09 | 305 | 111505 | 55523 | 64331399 |
Joint swelling | 140.65 | 10.09 | 101 | 111709 | 215281 | 64171641 |
Febrile neutropenia | 140.54 | 10.09 | 75 | 111735 | 187582 | 64199340 |
Contraindicated product administered | 139.41 | 10.09 | 13 | 111797 | 107816 | 64279106 |
Dissociation | 138.18 | 10.09 | 78 | 111732 | 2933 | 64383989 |
Insomnia | 137.99 | 10.09 | 693 | 111117 | 197143 | 64189779 |
Feeling of despair | 135.67 | 10.09 | 73 | 111737 | 2495 | 64384427 |
Anger | 132.99 | 10.09 | 150 | 111660 | 15591 | 64371331 |
Hyperhidrosis | 132.79 | 10.09 | 497 | 111313 | 124423 | 64262499 |
Extrapyramidal disorder | 125.39 | 10.09 | 162 | 111648 | 19390 | 64367532 |
Withdrawal syndrome | 125.35 | 10.09 | 178 | 111632 | 23314 | 64363608 |
Restlessness | 124.65 | 10.09 | 237 | 111573 | 39548 | 64347374 |
Drug intolerance | 122.93 | 10.09 | 88 | 111722 | 187904 | 64199018 |
Overdose | 122.04 | 10.09 | 574 | 111236 | 158992 | 64227930 |
Synovitis | 120.31 | 10.09 | 15 | 111795 | 99075 | 64287847 |
Impulsive behaviour | 116.86 | 10.09 | 67 | 111743 | 2596 | 64384326 |
Drug ineffective | 115.17 | 10.09 | 920 | 110890 | 839327 | 63547595 |
Homicide | 113.07 | 10.09 | 50 | 111760 | 1101 | 64385821 |
Intentional overdose | 111.99 | 10.09 | 377 | 111433 | 89567 | 64297355 |
Cogwheel rigidity | 109.98 | 10.09 | 66 | 111744 | 2787 | 64384135 |
Poisoning deliberate | 109.88 | 10.09 | 126 | 111684 | 13332 | 64373590 |
Dyskinesia | 106.96 | 10.09 | 221 | 111589 | 39167 | 64347755 |
Bradyphrenia | 106.90 | 10.09 | 105 | 111705 | 9301 | 64377621 |
Infusion related reaction | 103.63 | 10.09 | 80 | 111730 | 164387 | 64222535 |
Toxicity to various agents | 101.58 | 10.09 | 1019 | 110791 | 362494 | 64024428 |
Rash | 100.07 | 10.09 | 432 | 111378 | 458117 | 63928805 |
Treatment failure | 99.38 | 10.09 | 39 | 111771 | 116777 | 64270145 |
Gastric pH decreased | 99.15 | 10.09 | 40 | 111770 | 695 | 64386227 |
Coma | 94.25 | 10.09 | 350 | 111460 | 87265 | 64299657 |
Emotional disorder | 92.91 | 10.09 | 112 | 111698 | 12495 | 64374427 |
Pneumonia | 89.86 | 10.09 | 585 | 111225 | 558991 | 63827931 |
Alopecia | 89.52 | 10.09 | 93 | 111717 | 165597 | 64221325 |
Akathisia | 87.69 | 10.09 | 104 | 111706 | 11406 | 64375516 |
Rheumatoid arthritis | 86.77 | 10.09 | 94 | 111716 | 164200 | 64222722 |
Hallucination, auditory | 85.47 | 10.09 | 125 | 111685 | 16814 | 64370108 |
Hyperreflexia | 85.37 | 10.09 | 82 | 111728 | 7066 | 64379856 |
Agoraphobia | 85.09 | 10.09 | 33 | 111777 | 514 | 64386408 |
Hallucinations, mixed | 85.01 | 10.09 | 76 | 111734 | 5976 | 64380946 |
Memory impairment | 83.72 | 10.09 | 332 | 111478 | 85350 | 64301572 |
Drug dependence | 80.19 | 10.09 | 178 | 111632 | 33134 | 64353788 |
Cough | 79.21 | 10.09 | 264 | 111546 | 301884 | 64085038 |
Vertigo | 77.59 | 10.09 | 252 | 111558 | 58759 | 64328163 |
Muscle rigidity | 76.91 | 10.09 | 121 | 111689 | 17352 | 64369570 |
Sepsis | 76.90 | 10.09 | 179 | 111631 | 230162 | 64156760 |
Delirium | 76.58 | 10.09 | 279 | 111531 | 68915 | 64318007 |
Altered state of consciousness | 76.47 | 10.09 | 189 | 111621 | 37713 | 64349209 |
Peripheral swelling | 74.36 | 10.09 | 157 | 111653 | 208996 | 64177926 |
Flat affect | 71.69 | 10.09 | 43 | 111767 | 1814 | 64385108 |
Homicidal ideation | 71.34 | 10.09 | 53 | 111757 | 3204 | 64383718 |
Nervousness | 71.22 | 10.09 | 158 | 111652 | 29398 | 64357524 |
Systemic lupus erythematosus | 70.97 | 10.09 | 23 | 111787 | 77589 | 64309333 |
Paraesthesia | 70.21 | 10.09 | 436 | 111374 | 134086 | 64252836 |
Glossodynia | 69.06 | 10.09 | 14 | 111796 | 64682 | 64322240 |
Malignant neoplasm progression | 68.45 | 10.09 | 57 | 111753 | 112814 | 64274108 |
Product use issue | 67.40 | 10.09 | 99 | 111711 | 151616 | 64235306 |
Crying | 67.06 | 10.09 | 123 | 111687 | 19967 | 64366955 |
Swelling | 66.92 | 10.09 | 109 | 111701 | 160109 | 64226813 |
Feeling jittery | 66.45 | 10.09 | 87 | 111723 | 10548 | 64376374 |
Bronchial neoplasm | 66.35 | 10.09 | 26 | 111784 | 417 | 64386505 |
Myoclonus | 65.93 | 10.09 | 139 | 111671 | 24979 | 64361943 |
Libido increased | 65.37 | 10.09 | 40 | 111770 | 1750 | 64385172 |
Depressed level of consciousness | 64.43 | 10.09 | 296 | 111514 | 81140 | 64305782 |
Parkinsonism | 63.91 | 10.09 | 100 | 111710 | 14273 | 64372649 |
Sleep disorder | 63.75 | 10.09 | 238 | 111572 | 59471 | 64327451 |
Pericarditis | 63.75 | 10.09 | 15 | 111795 | 62501 | 64324421 |
Hypersensitivity | 63.70 | 10.09 | 155 | 111655 | 196297 | 64190625 |
Abnormal behaviour | 62.97 | 10.09 | 163 | 111647 | 33459 | 64353463 |
Myoglobin urine present | 62.41 | 10.09 | 27 | 111783 | 563 | 64386359 |
Tearfulness | 60.38 | 10.09 | 56 | 111754 | 4617 | 64382305 |
Hypomania | 60.34 | 10.09 | 61 | 111749 | 5593 | 64381329 |
Speech disorder | 58.47 | 10.09 | 201 | 111609 | 48240 | 64338682 |
Depressed mood | 58.36 | 10.09 | 180 | 111630 | 40832 | 64346090 |
Affective disorder | 57.80 | 10.09 | 64 | 111746 | 6516 | 64380406 |
Nasal turbinate hypertrophy | 56.55 | 10.09 | 25 | 111785 | 550 | 64386372 |
Psychotic disorder | 56.10 | 10.09 | 159 | 111651 | 34419 | 64352503 |
Libido decreased | 55.47 | 10.09 | 54 | 111756 | 4730 | 64382192 |
Hepatic enzyme increased | 54.63 | 10.09 | 88 | 111722 | 129855 | 64257067 |
H1N1 influenza | 54.45 | 10.09 | 39 | 111771 | 2227 | 64384695 |
Therapeutic product effect decreased | 53.48 | 10.09 | 73 | 111737 | 115278 | 64271644 |
Clonus | 53.27 | 10.09 | 59 | 111751 | 6008 | 64380914 |
Menstrual disorder | 52.78 | 10.09 | 45 | 111765 | 3320 | 64383602 |
Neutropenia | 52.60 | 10.09 | 225 | 111585 | 239399 | 64147523 |
Intentional product use issue | 52.08 | 10.09 | 53 | 111757 | 95311 | 64291611 |
Endometrial ablation | 51.57 | 10.09 | 26 | 111784 | 775 | 64386147 |
Dystonia | 51.38 | 10.09 | 106 | 111704 | 18759 | 64368163 |
Paranoia | 50.70 | 10.09 | 97 | 111713 | 16255 | 64370667 |
Feeling of body temperature change | 49.67 | 10.09 | 51 | 111759 | 4763 | 64382159 |
Amnesia | 49.54 | 10.09 | 190 | 111620 | 48079 | 64338843 |
Arthropathy | 48.92 | 10.09 | 84 | 111726 | 120883 | 64266039 |
Delusion | 48.81 | 10.09 | 101 | 111709 | 17913 | 64369009 |
Tinnitus | 48.74 | 10.09 | 150 | 111660 | 33983 | 64352939 |
Helicobacter infection | 48.58 | 10.09 | 5 | 111805 | 38357 | 64348565 |
Muscle twitching | 48.55 | 10.09 | 104 | 111706 | 18894 | 64368028 |
Death | 48.26 | 10.09 | 570 | 111240 | 482135 | 63904787 |
Parosmia | 47.59 | 10.09 | 49 | 111761 | 4591 | 64382331 |
Disease progression | 47.33 | 10.09 | 110 | 111700 | 141570 | 64245352 |
Personality disorder | 46.97 | 10.09 | 49 | 111761 | 4662 | 64382260 |
Cytomegalovirus infection | 46.72 | 10.09 | 5 | 111805 | 37194 | 64349728 |
Restless legs syndrome | 46.41 | 10.09 | 96 | 111714 | 17020 | 64369902 |
Loss of consciousness | 46.29 | 10.09 | 426 | 111384 | 147939 | 64238983 |
Lower respiratory tract infection | 45.77 | 10.09 | 58 | 111752 | 94556 | 64292366 |
Self esteem decreased | 45.48 | 10.09 | 25 | 111785 | 892 | 64386030 |
Pain | 45.03 | 10.09 | 682 | 111128 | 552829 | 63834093 |
Dyspnoea | 44.38 | 10.09 | 930 | 110880 | 717744 | 63669178 |
Nasopharyngitis | 44.33 | 10.09 | 182 | 111628 | 195891 | 64191031 |
Emotional distress | 43.89 | 10.09 | 150 | 111660 | 35888 | 64351034 |
Stomatitis | 43.51 | 10.09 | 77 | 111733 | 109528 | 64277394 |
Muscle disorder | 43.22 | 10.09 | 48 | 111762 | 4903 | 64382019 |
Euphoric mood | 42.87 | 10.09 | 55 | 111755 | 6536 | 64380386 |
Pancytopenia | 42.66 | 10.09 | 118 | 111692 | 143191 | 64243731 |
Fall | 42.44 | 10.09 | 983 | 110827 | 415843 | 63971079 |
Seizure | 42.29 | 10.09 | 459 | 111351 | 166433 | 64220489 |
Sexual dysfunction | 42.09 | 10.09 | 54 | 111756 | 6417 | 64380505 |
Drooling | 42.08 | 10.09 | 49 | 111761 | 5270 | 64381652 |
Gun shot wound | 42.01 | 10.09 | 25 | 111785 | 1039 | 64385883 |
Blister | 41.98 | 10.09 | 47 | 111763 | 80920 | 64306002 |
Hyperacusis | 41.15 | 10.09 | 31 | 111779 | 1914 | 64385008 |
Therapeutic product ineffective | 40.93 | 10.09 | 28 | 111782 | 1485 | 64385437 |
Infection | 40.92 | 10.09 | 173 | 111637 | 184707 | 64202215 |
Hepatocellular injury | 40.77 | 10.09 | 171 | 111639 | 45064 | 64341858 |
Galactorrhoea | 40.48 | 10.09 | 38 | 111772 | 3181 | 64383741 |
Bipolar disorder | 40.22 | 10.09 | 54 | 111756 | 6707 | 64380215 |
Logorrhoea | 40.08 | 10.09 | 42 | 111768 | 4017 | 64382905 |
Thrombocytopenia | 39.96 | 10.09 | 226 | 111584 | 223575 | 64163347 |
Anaemia | 39.83 | 10.09 | 442 | 111368 | 378238 | 64008684 |
Neutrophil count decreased | 39.81 | 10.09 | 45 | 111765 | 77151 | 64309771 |
Hangover | 39.56 | 10.09 | 30 | 111780 | 1871 | 64385051 |
Hallucination | 39.26 | 10.09 | 238 | 111572 | 72550 | 64314372 |
Abnormal dreams | 39.20 | 10.09 | 67 | 111743 | 10289 | 64376633 |
Tachycardia | 39.11 | 10.09 | 414 | 111396 | 149165 | 64237757 |
Bronchial haemorrhage | 38.83 | 10.09 | 25 | 111785 | 1197 | 64385725 |
Hyperprolactinaemia | 38.25 | 10.09 | 41 | 111769 | 4024 | 64382898 |
Dizziness | 38.25 | 10.09 | 996 | 110814 | 429167 | 63957755 |
Acute kidney injury | 38.07 | 10.09 | 549 | 111261 | 448691 | 63938231 |
Erectile dysfunction | 38.04 | 10.09 | 74 | 111736 | 12553 | 64374369 |
Wound | 37.92 | 10.09 | 46 | 111764 | 76431 | 64310491 |
Blood creatine phosphokinase increased | 37.87 | 10.09 | 201 | 111609 | 58357 | 64328565 |
Cardio-respiratory arrest | 37.80 | 10.09 | 296 | 111514 | 98097 | 64288825 |
Hostility | 37.69 | 10.09 | 31 | 111779 | 2176 | 64384746 |
Hyperthermia | 37.31 | 10.09 | 83 | 111727 | 15467 | 64371455 |
Septic shock | 36.73 | 10.09 | 80 | 111730 | 105357 | 64281565 |
Incontinence | 36.64 | 10.09 | 71 | 111739 | 12010 | 64374912 |
Renal ischaemia | 36.51 | 10.09 | 23 | 111787 | 1060 | 64385862 |
PCO2 increased | 36.23 | 10.09 | 27 | 111783 | 1640 | 64385282 |
Hallucination, visual | 35.80 | 10.09 | 118 | 111692 | 27716 | 64359206 |
Psychomotor hyperactivity | 35.66 | 10.09 | 78 | 111732 | 14373 | 64372549 |
General physical health deterioration | 35.65 | 10.09 | 208 | 111602 | 204217 | 64182705 |
Drug abuser | 35.49 | 10.09 | 47 | 111763 | 5761 | 64381161 |
Pyrexia | 34.69 | 10.09 | 722 | 111088 | 557922 | 63829000 |
Verbal abuse | 34.35 | 10.09 | 14 | 111796 | 250 | 64386672 |
Visceral congestion | 34.26 | 10.09 | 20 | 111790 | 802 | 64386120 |
Abdominal discomfort | 34.25 | 10.09 | 181 | 111629 | 182141 | 64204781 |
Neuropathy peripheral | 34.06 | 10.09 | 98 | 111712 | 117427 | 64269495 |
COVID-19 | 33.56 | 10.09 | 38 | 111772 | 65102 | 64321820 |
Physical assault | 33.51 | 10.09 | 25 | 111785 | 1521 | 64385401 |
Social anxiety disorder | 33.12 | 10.09 | 16 | 111794 | 434 | 64386488 |
Thinking abnormal | 32.73 | 10.09 | 66 | 111744 | 11490 | 64375432 |
Fear | 31.98 | 10.09 | 92 | 111718 | 20079 | 64366843 |
Blepharospasm | 31.69 | 10.09 | 34 | 111776 | 3341 | 64383581 |
Apathy | 31.64 | 10.09 | 64 | 111746 | 11168 | 64375754 |
Arthralgia | 31.59 | 10.09 | 558 | 111252 | 441702 | 63945220 |
Loss of libido | 31.43 | 10.09 | 29 | 111781 | 2375 | 64384547 |
Product complaint | 31.19 | 10.09 | 66 | 111744 | 11888 | 64375034 |
Rhonchi | 30.97 | 10.09 | 34 | 111776 | 3429 | 64383493 |
Atrial fibrillation | 30.94 | 10.09 | 172 | 111638 | 170917 | 64216005 |
Joint hyperextension | 30.87 | 10.09 | 13 | 111797 | 253 | 64386669 |
Mobility decreased | 30.84 | 10.09 | 64 | 111746 | 85776 | 64301146 |
Schizophrenia | 30.70 | 10.09 | 63 | 111747 | 11105 | 64375817 |
Hypoaesthesia oral | 30.29 | 10.09 | 64 | 111746 | 11516 | 64375406 |
Dependence | 30.14 | 10.09 | 27 | 111783 | 2128 | 64384794 |
Sensory loss | 29.91 | 10.09 | 59 | 111751 | 10110 | 64376812 |
Urinary retention | 29.86 | 10.09 | 166 | 111644 | 49035 | 64337887 |
Chorea | 29.85 | 10.09 | 26 | 111784 | 1974 | 64384948 |
Premature labour | 29.77 | 10.09 | 50 | 111760 | 7570 | 64379352 |
Anorgasmia | 29.13 | 10.09 | 19 | 111791 | 930 | 64385992 |
C-reactive protein increased | 29.10 | 10.09 | 77 | 111733 | 94832 | 64292090 |
Soft tissue injury | 28.70 | 10.09 | 23 | 111787 | 1556 | 64385366 |
Apraxia | 28.63 | 10.09 | 28 | 111782 | 2467 | 64384455 |
Bronchial disorder | 28.60 | 10.09 | 26 | 111784 | 2089 | 64384833 |
Mucosal inflammation | 28.60 | 10.09 | 40 | 111770 | 62544 | 64324378 |
Abdominal pain | 28.48 | 10.09 | 376 | 111434 | 311999 | 64074923 |
Mood altered | 28.42 | 10.09 | 76 | 111734 | 15903 | 64371019 |
Poisoning | 28.36 | 10.09 | 93 | 111717 | 21786 | 64365136 |
Myelosuppression | 27.98 | 10.09 | 4 | 111806 | 23826 | 64363096 |
Injection site erythema | 27.86 | 10.09 | 50 | 111760 | 70750 | 64316172 |
Oral discharge | 27.83 | 10.09 | 12 | 111798 | 248 | 64386674 |
Cerebral microhaemorrhage | 27.65 | 10.09 | 11 | 111799 | 184 | 64386738 |
Injection site pain | 27.35 | 10.09 | 100 | 111710 | 111308 | 64275614 |
Neutropenic sepsis | 27.10 | 10.09 | 4 | 111806 | 23268 | 64363654 |
Ejaculation failure | 27.06 | 10.09 | 13 | 111797 | 348 | 64386574 |
Sensory disturbance | 26.78 | 10.09 | 66 | 111744 | 13142 | 64373780 |
Hypertonia | 26.73 | 10.09 | 43 | 111767 | 6282 | 64380640 |
Coma scale | 26.59 | 10.09 | 8 | 111802 | 54 | 64386868 |
Tension | 26.49 | 10.09 | 33 | 111777 | 3807 | 64383115 |
Obsessive-compulsive disorder | 26.43 | 10.09 | 37 | 111773 | 4781 | 64382141 |
Respiratory acidosis | 26.40 | 10.09 | 55 | 111755 | 9800 | 64377122 |
Asphyxia | 26.34 | 10.09 | 54 | 111756 | 9512 | 64377410 |
Balance disorder | 26.16 | 10.09 | 241 | 111569 | 83685 | 64303237 |
Weight increased | 26.12 | 10.09 | 517 | 111293 | 212831 | 64174091 |
Ascites | 26.04 | 10.09 | 42 | 111768 | 61959 | 64324963 |
Chemical submission | 25.98 | 10.09 | 11 | 111799 | 217 | 64386705 |
Erythema | 25.80 | 10.09 | 204 | 111606 | 186866 | 64200056 |
Feeling abnormal | 25.77 | 10.09 | 349 | 111461 | 133253 | 64253669 |
White blood cell count decreased | 25.72 | 10.09 | 164 | 111646 | 157673 | 64229249 |
Anaphylactic reaction | 25.68 | 10.09 | 50 | 111760 | 68614 | 64318308 |
Folliculitis | 25.63 | 10.09 | 10 | 111800 | 30067 | 64356855 |
Obsessive thoughts | 25.59 | 10.09 | 18 | 111792 | 999 | 64385923 |
PO2 increased | 25.57 | 10.09 | 21 | 111789 | 1471 | 64385451 |
Congenital hydrocephalus | 25.37 | 10.09 | 7 | 111803 | 33 | 64386889 |
Cognitive disorder | 25.32 | 10.09 | 173 | 111637 | 54914 | 64332008 |
Dysarthria | 25.22 | 10.09 | 183 | 111627 | 59223 | 64327699 |
Gastrointestinal disorder | 25.13 | 10.09 | 76 | 111734 | 89633 | 64297289 |
Creutzfeldt-Jakob disease | 24.88 | 10.09 | 10 | 111800 | 172 | 64386750 |
Sinus tachycardia | 24.71 | 10.09 | 116 | 111694 | 32072 | 64354850 |
Eye movement disorder | 24.46 | 10.09 | 44 | 111766 | 7035 | 64379887 |
Hepatotoxicity | 24.44 | 10.09 | 20 | 111790 | 39942 | 64346980 |
Pain in extremity | 24.38 | 10.09 | 374 | 111436 | 302711 | 64084211 |
Electroencephalogram abnormal | 24.25 | 10.09 | 37 | 111773 | 5166 | 64381756 |
Electrocardiogram QT prolonged | 24.19 | 10.09 | 227 | 111583 | 79221 | 64307701 |
Platelet count decreased | 24.01 | 10.09 | 181 | 111629 | 167530 | 64219392 |
Accidental poisoning | 23.96 | 10.09 | 20 | 111790 | 1433 | 64385489 |
Substance abuse | 23.89 | 10.09 | 51 | 111759 | 9241 | 64377681 |
Pneumocystis jirovecii pneumonia | 23.86 | 10.09 | 9 | 111801 | 27625 | 64359297 |
Major depression | 23.78 | 10.09 | 46 | 111764 | 7770 | 64379152 |
Head titubation | 23.72 | 10.09 | 16 | 111794 | 829 | 64386093 |
Vision blurred | 23.60 | 10.09 | 250 | 111560 | 90066 | 64296856 |
Paralysis | 23.57 | 10.09 | 58 | 111752 | 11537 | 64375385 |
Rhabdomyolysis | 23.55 | 10.09 | 253 | 111557 | 91473 | 64295449 |
Arthritis | 23.48 | 10.09 | 71 | 111739 | 83743 | 64303179 |
Antidepressant discontinuation syndrome | 23.34 | 10.09 | 5 | 111805 | 5 | 64386917 |
Ejaculation delayed | 23.22 | 10.09 | 9 | 111801 | 140 | 64386782 |
Haemoglobin decreased | 23.21 | 10.09 | 221 | 111589 | 194842 | 64192080 |
Post-traumatic neck syndrome | 23.05 | 10.09 | 22 | 111788 | 1880 | 64385042 |
Diarrhoea | 22.95 | 10.09 | 1022 | 110788 | 721682 | 63665240 |
Hypokinesia | 22.83 | 10.09 | 72 | 111738 | 16524 | 64370398 |
Panic disorder | 22.82 | 10.09 | 26 | 111784 | 2731 | 64384191 |
Affect lability | 22.72 | 10.09 | 49 | 111761 | 8941 | 64377981 |
Depressive symptom | 22.42 | 10.09 | 33 | 111777 | 4463 | 64382459 |
Muscle injury | 22.19 | 10.09 | 9 | 111801 | 26428 | 64360494 |
Social avoidant behaviour | 22.08 | 10.09 | 33 | 111777 | 4524 | 64382398 |
Metastases to liver | 22.05 | 10.09 | 7 | 111803 | 23934 | 64362988 |
Oxygen saturation abnormal | 21.98 | 10.09 | 29 | 111781 | 3542 | 64383380 |
Cardiac failure | 21.85 | 10.09 | 137 | 111673 | 132236 | 64254686 |
Bradykinesia | 21.69 | 10.09 | 40 | 111770 | 6520 | 64380402 |
Trichotillomania | 21.52 | 10.09 | 9 | 111801 | 172 | 64386750 |
Negative thoughts | 21.44 | 10.09 | 18 | 111792 | 1300 | 64385622 |
Idiosyncratic alcohol intoxication | 21.44 | 10.09 | 4 | 111806 | 0 | 64386922 |
Self-injurious ideation | 21.30 | 10.09 | 27 | 111783 | 3170 | 64383752 |
Pneumonitis | 21.26 | 10.09 | 34 | 111776 | 50331 | 64336591 |
Clostridium difficile infection | 21.02 | 10.09 | 19 | 111791 | 36144 | 64350778 |
Oropharyngeal pain | 21.01 | 10.09 | 81 | 111729 | 88786 | 64298136 |
Inadequate analgesia | 21.01 | 10.09 | 30 | 111780 | 3948 | 64382974 |
Discomfort | 20.92 | 10.09 | 71 | 111739 | 80807 | 64306115 |
Mental disorder | 20.81 | 10.09 | 96 | 111714 | 26349 | 64360573 |
Feelings of worthlessness | 20.72 | 10.09 | 12 | 111798 | 474 | 64386448 |
Incoherent | 20.58 | 10.09 | 41 | 111769 | 7077 | 64379845 |
Multiple organ dysfunction syndrome | 20.56 | 10.09 | 98 | 111712 | 101315 | 64285607 |
Psychiatric symptom | 20.42 | 10.09 | 38 | 111772 | 6235 | 64380687 |
Treatment noncompliance | 20.25 | 10.09 | 137 | 111673 | 43345 | 64343577 |
Breath sounds abnormal | 20.25 | 10.09 | 55 | 111755 | 11614 | 64375308 |
Product use in unapproved indication | 20.21 | 10.09 | 202 | 111608 | 176416 | 64210506 |
Musculoskeletal pain | 19.93 | 10.09 | 73 | 111737 | 81221 | 64305701 |
Leukopenia | 19.85 | 10.09 | 99 | 111711 | 101143 | 64285779 |
Product dose omission issue | 19.77 | 10.09 | 229 | 111581 | 194518 | 64192404 |
Feeling guilty | 19.40 | 10.09 | 14 | 111796 | 809 | 64386113 |
Posterior reversible encephalopathy syndrome | 18.95 | 10.09 | 8 | 111802 | 22938 | 64363984 |
Rhinitis | 18.94 | 10.09 | 51 | 111759 | 10714 | 64376208 |
Blood sodium decreased | 18.92 | 10.09 | 101 | 111709 | 29381 | 64357541 |
Somatic dysfunction | 18.78 | 10.09 | 5 | 111805 | 20 | 64386902 |
Tardive dyskinesia | 18.75 | 10.09 | 46 | 111764 | 9132 | 64377790 |
Illusion | 18.73 | 10.09 | 18 | 111792 | 1552 | 64385370 |
Renal impairment | 18.72 | 10.09 | 147 | 111663 | 134870 | 64252052 |
Blood pH decreased | 18.70 | 10.09 | 30 | 111780 | 4372 | 64382550 |
Aspergillus infection | 18.65 | 10.09 | 3 | 111807 | 16376 | 64370546 |
Housebound | 18.56 | 10.09 | 11 | 111799 | 454 | 64386468 |
Intentional device use issue | 18.40 | 10.09 | 5 | 111805 | 22 | 64386900 |
Alcoholism | 18.38 | 10.09 | 26 | 111784 | 3391 | 64383531 |
Sinusitis | 18.36 | 10.09 | 163 | 111647 | 145765 | 64241157 |
Hip arthroplasty | 18.36 | 10.09 | 7 | 111803 | 21344 | 64365578 |
Sternal fracture | 18.28 | 10.09 | 21 | 111789 | 2226 | 64384696 |
Foetal death | 18.16 | 10.09 | 35 | 111775 | 5895 | 64381027 |
Diabetes insipidus | 18.11 | 10.09 | 30 | 111780 | 4491 | 64382431 |
Epistaxis | 18.09 | 10.09 | 98 | 111712 | 98033 | 64288889 |
Myoglobin blood increased | 17.99 | 10.09 | 23 | 111787 | 2724 | 64384198 |
Vasoplegia syndrome | 17.85 | 10.09 | 23 | 111787 | 2744 | 64384178 |
Alcohol abuse | 17.85 | 10.09 | 31 | 111779 | 4821 | 64382101 |
Middle insomnia | 17.83 | 10.09 | 56 | 111754 | 12821 | 64374101 |
Hyperlipidaemia | 17.78 | 10.09 | 83 | 111727 | 22893 | 64364029 |
Drug screen positive | 17.78 | 10.09 | 34 | 111776 | 5695 | 64381227 |
Ejaculation disorder | 17.66 | 10.09 | 11 | 111799 | 497 | 64386425 |
Cytokine release syndrome | 17.63 | 10.09 | 7 | 111803 | 20822 | 64366100 |
Migraine | 17.56 | 10.09 | 176 | 111634 | 62501 | 64324421 |
Hospitalisation | 17.49 | 10.09 | 69 | 111741 | 75138 | 64311784 |
Generalised anxiety disorder | 17.47 | 10.09 | 19 | 111791 | 1896 | 64385026 |
Red blood cell sedimentation rate increased | 17.46 | 10.09 | 17 | 111793 | 31218 | 64355704 |
Poriomania | 17.34 | 10.09 | 8 | 111802 | 195 | 64386727 |
Hypoaesthesia | 17.31 | 10.09 | 338 | 111472 | 138770 | 64248152 |
Obesity | 17.19 | 10.09 | 76 | 111734 | 20486 | 64366436 |
Inflammation | 17.11 | 10.09 | 57 | 111753 | 65243 | 64321679 |
Therapeutic response decreased | 17.03 | 10.09 | 41 | 111769 | 52147 | 64334775 |
Hypervolaemia | 16.97 | 10.09 | 25 | 111785 | 38260 | 64348662 |
Muscle tightness | 16.95 | 10.09 | 50 | 111760 | 11065 | 64375857 |
Psoriatic arthropathy | 16.64 | 10.09 | 31 | 111779 | 43250 | 64343672 |
Drug reaction with eosinophilia and systemic symptoms | 16.60 | 10.09 | 44 | 111766 | 54173 | 64332749 |
Parkinson's disease | 16.59 | 10.09 | 17 | 111793 | 1584 | 64385338 |
Campylobacter colitis | 16.59 | 10.09 | 5 | 111805 | 34 | 64386888 |
Poor quality sleep | 16.58 | 10.09 | 71 | 111739 | 18880 | 64368042 |
Injection site pruritus | 16.47 | 10.09 | 25 | 111785 | 37801 | 64349121 |
Resting tremor | 16.47 | 10.09 | 16 | 111794 | 1398 | 64385524 |
Cellulitis | 16.47 | 10.09 | 95 | 111715 | 93562 | 64293360 |
Encephalopathy | 16.40 | 10.09 | 165 | 111645 | 58654 | 64328268 |
Hyperkinesia | 16.17 | 10.09 | 21 | 111789 | 2525 | 64384397 |
Soliloquy | 16.15 | 10.09 | 11 | 111799 | 579 | 64386343 |
Judgement impaired | 16.12 | 10.09 | 14 | 111796 | 1059 | 64385863 |
Dysacusis | 16.08 | 10.09 | 3 | 111807 | 0 | 64386922 |
Brugada syndrome | 16.06 | 10.09 | 14 | 111796 | 1064 | 64385858 |
Liver function test increased | 16.02 | 10.09 | 18 | 111792 | 30952 | 64355970 |
Colitis microscopic | 15.99 | 10.09 | 38 | 111772 | 7394 | 64379528 |
Reversible cerebral vasoconstriction syndrome | 15.95 | 10.09 | 20 | 111790 | 2322 | 64384600 |
Urinary tract infection | 15.93 | 10.09 | 294 | 111516 | 231302 | 64155620 |
Persecutory delusion | 15.87 | 10.09 | 27 | 111783 | 4131 | 64382791 |
Urticaria | 15.83 | 10.09 | 171 | 111639 | 147146 | 64239776 |
Oedema | 15.76 | 10.09 | 94 | 111716 | 91841 | 64295081 |
Palmar-plantar erythrodysaesthesia syndrome | 15.75 | 10.09 | 16 | 111794 | 28803 | 64358119 |
Phonophobia | 15.70 | 10.09 | 10 | 111800 | 470 | 64386452 |
Impaired healing | 15.69 | 10.09 | 53 | 111757 | 60420 | 64326502 |
Tri-iodothyronine free decreased | 15.62 | 10.09 | 9 | 111801 | 352 | 64386570 |
Compartment syndrome | 15.52 | 10.09 | 27 | 111783 | 4205 | 64382717 |
Vascular stenosis | 15.51 | 10.09 | 10 | 111800 | 480 | 64386442 |
Drug resistance | 15.48 | 10.09 | 23 | 111787 | 35079 | 64351843 |
Anticholinergic syndrome | 15.39 | 10.09 | 21 | 111789 | 2648 | 64384274 |
Altered visual depth perception | 15.32 | 10.09 | 9 | 111801 | 365 | 64386557 |
Infusion site scar | 15.32 | 10.09 | 8 | 111802 | 257 | 64386665 |
Bronchopulmonary aspergillosis | 15.22 | 10.09 | 7 | 111803 | 19078 | 64367844 |
Neoplasm progression | 15.17 | 10.09 | 30 | 111780 | 40934 | 64345988 |
Blood pressure diastolic decreased | 15.14 | 10.09 | 10 | 111800 | 22291 | 64364631 |
Lactose intolerance | 15 | 10.09 | 18 | 111792 | 1998 | 64384924 |
Blood chloride decreased | 14.97 | 10.09 | 37 | 111773 | 7379 | 64379543 |
Increased appetite | 14.87 | 10.09 | 45 | 111765 | 10101 | 64376821 |
Hyperventilation | 14.74 | 10.09 | 35 | 111775 | 6805 | 64380117 |
Delivery | 14.74 | 10.09 | 10 | 111800 | 523 | 64386399 |
Psychomotor skills impaired | 14.72 | 10.09 | 25 | 111785 | 3820 | 64383102 |
Decreased activity | 14.68 | 10.09 | 36 | 111774 | 7144 | 64379778 |
Bone marrow failure | 14.62 | 10.09 | 39 | 111771 | 47913 | 64339009 |
Amimia | 14.55 | 10.09 | 5 | 111805 | 54 | 64386868 |
Dissociative amnesia | 14.48 | 10.09 | 6 | 111804 | 112 | 64386810 |
Sedation | 14.44 | 10.09 | 122 | 111688 | 41340 | 64345582 |
Dairy intolerance | 14.39 | 10.09 | 5 | 111805 | 56 | 64386866 |
Endocrine ophthalmopathy | 14.38 | 10.09 | 9 | 111801 | 410 | 64386512 |
Cystocele | 14.34 | 10.09 | 11 | 111799 | 698 | 64386224 |
Diabetic hyperosmolar coma | 14.24 | 10.09 | 11 | 111799 | 705 | 64386217 |
Tumour lysis syndrome | 14.20 | 10.09 | 8 | 111802 | 19432 | 64367490 |
Epilepsy | 14.06 | 10.09 | 103 | 111707 | 33428 | 64353494 |
Antiphospholipid antibodies | 14.01 | 10.09 | 6 | 111804 | 122 | 64386800 |
Pleural effusion | 13.96 | 10.09 | 146 | 111664 | 126413 | 64260509 |
Maternal exposure during pregnancy | 13.94 | 10.09 | 103 | 111707 | 95781 | 64291141 |
Suspiciousness | 13.81 | 10.09 | 10 | 111800 | 581 | 64386341 |
Basal cell carcinoma | 13.80 | 10.09 | 20 | 111790 | 30818 | 64356104 |
Clumsiness | 13.78 | 10.09 | 20 | 111790 | 2671 | 64384251 |
Therapy non-responder | 13.76 | 10.09 | 63 | 111747 | 65836 | 64321086 |
Generalised tonic-clonic seizure | 13.73 | 10.09 | 117 | 111693 | 39740 | 64347182 |
Marital problem | 13.72 | 10.09 | 7 | 111803 | 214 | 64386708 |
Cyanosis | 13.61 | 10.09 | 75 | 111735 | 22080 | 64364842 |
Jealous delusion | 13.54 | 10.09 | 7 | 111803 | 220 | 64386702 |
Plasmodium vivax infection | 13.54 | 10.09 | 3 | 111807 | 4 | 64386918 |
Injection site reaction | 13.45 | 10.09 | 39 | 111771 | 46625 | 64340297 |
Slow response to stimuli | 13.36 | 10.09 | 15 | 111795 | 1550 | 64385372 |
Mental impairment | 13.36 | 10.09 | 60 | 111750 | 16283 | 64370639 |
Catatonia | 13.31 | 10.09 | 36 | 111774 | 7584 | 64379338 |
Gastrointestinal haemorrhage | 13.26 | 10.09 | 156 | 111654 | 132156 | 64254766 |
Antisocial personality disorder | 13.17 | 10.09 | 4 | 111806 | 28 | 64386894 |
Stupor | 13.14 | 10.09 | 31 | 111779 | 6004 | 64380918 |
Gaze palsy | 13.13 | 10.09 | 19 | 111791 | 2531 | 64384391 |
Localised infection | 13.07 | 10.09 | 20 | 111790 | 30141 | 64356781 |
Influenza like illness | 13.07 | 10.09 | 164 | 111646 | 61538 | 64325384 |
Blood pressure systolic increased | 13.07 | 10.09 | 43 | 111767 | 49410 | 64337512 |
Transaminases increased | 13.05 | 10.09 | 37 | 111773 | 44557 | 64342365 |
Fluid retention | 13.04 | 10.09 | 56 | 111754 | 59550 | 64327372 |
Inappropriate schedule of product administration | 13.01 | 10.09 | 100 | 111710 | 92186 | 64294736 |
Loss of personal independence in daily activities | 13 | 10.09 | 73 | 111737 | 72381 | 64314541 |
Bradycardia | 12.98 | 10.09 | 282 | 111528 | 117937 | 64268985 |
Hypersomnia | 12.96 | 10.09 | 68 | 111742 | 19649 | 64367273 |
Spinal pain | 12.92 | 10.09 | 3 | 111807 | 12618 | 64374304 |
Posture abnormal | 12.84 | 10.09 | 22 | 111788 | 3384 | 64383538 |
Cerebrovascular stenosis | 12.80 | 10.09 | 6 | 111804 | 152 | 64386770 |
Diet refusal | 12.78 | 10.09 | 11 | 111799 | 822 | 64386100 |
Tonic convulsion | 12.71 | 10.09 | 16 | 111794 | 1865 | 64385057 |
Thought insertion | 12.70 | 10.09 | 4 | 111806 | 32 | 64386890 |
Toxicologic test abnormal | 12.68 | 10.09 | 13 | 111797 | 1212 | 64385710 |
Device related infection | 12.62 | 10.09 | 21 | 111789 | 30605 | 64356317 |
Perseveration | 12.60 | 10.09 | 8 | 111802 | 374 | 64386548 |
Ammonia abnormal | 12.55 | 10.09 | 6 | 111804 | 159 | 64386763 |
Cholecystitis chronic | 12.51 | 10.09 | 40 | 111770 | 9247 | 64377675 |
Hyperbilirubinaemia | 12.49 | 10.09 | 11 | 111799 | 21194 | 64365728 |
Laboratory test abnormal | 12.43 | 10.09 | 14 | 111796 | 24049 | 64362873 |
Acute respiratory distress syndrome | 12.38 | 10.09 | 31 | 111779 | 38904 | 64348018 |
Violence-related symptom | 12.37 | 10.09 | 10 | 111800 | 685 | 64386237 |
Blood triglycerides increased | 12.36 | 10.09 | 65 | 111745 | 18801 | 64368121 |
Intention tremor | 12.36 | 10.09 | 10 | 111800 | 686 | 64386236 |
Chronic kidney disease | 12.31 | 10.09 | 55 | 111755 | 57864 | 64329058 |
Colitis | 12.30 | 10.09 | 56 | 111754 | 58618 | 64328304 |
Therapy interrupted | 12.29 | 10.09 | 10 | 111800 | 20026 | 64366896 |
Hypercholesterolaemia | 12.24 | 10.09 | 56 | 111754 | 15317 | 64371605 |
Plasma cell myeloma | 12.22 | 10.09 | 40 | 111770 | 46035 | 64340887 |
Autoimmune nephritis | 12.20 | 10.09 | 9 | 111801 | 538 | 64386384 |
Serum sickness-like reaction | 12.16 | 10.09 | 9 | 111801 | 541 | 64386381 |
Aphasia | 12.01 | 10.09 | 116 | 111694 | 40790 | 64346132 |
Disinhibition | 11.97 | 10.09 | 17 | 111793 | 2226 | 64384696 |
Oscillopsia | 11.93 | 10.09 | 6 | 111804 | 178 | 64386744 |
Hyposmia | 11.84 | 10.09 | 9 | 111801 | 563 | 64386359 |
Skin necrosis | 11.83 | 10.09 | 5 | 111805 | 14324 | 64372598 |
Mouth ulceration | 11.81 | 10.09 | 24 | 111786 | 32420 | 64354502 |
Fatigue | 11.78 | 10.09 | 1128 | 110682 | 747602 | 63639320 |
Pruritus | 11.74 | 10.09 | 433 | 111377 | 311967 | 64074955 |
Blood aldosterone abnormal | 11.74 | 10.09 | 4 | 111806 | 42 | 64386880 |
Dyssomnia | 11.74 | 10.09 | 4 | 111806 | 42 | 64386880 |
Coronary artery disease | 11.70 | 10.09 | 158 | 111652 | 60275 | 64326647 |
Nephropathy toxic | 11.69 | 10.09 | 8 | 111802 | 17506 | 64369416 |
Subdural haematoma | 11.66 | 10.09 | 86 | 111724 | 27968 | 64358954 |
Injection site swelling | 11.60 | 10.09 | 35 | 111775 | 41318 | 64345604 |
Impulse-control disorder | 11.52 | 10.09 | 14 | 111796 | 1574 | 64385348 |
Toxic epidermal necrolysis | 11.50 | 10.09 | 30 | 111780 | 37136 | 64349786 |
Back pain | 11.47 | 10.09 | 338 | 111472 | 249833 | 64137089 |
Fibrocystic breast disease | 11.44 | 10.09 | 9 | 111801 | 593 | 64386329 |
Prescription drug used without a prescription | 11.43 | 10.09 | 18 | 111792 | 2582 | 64384340 |
Suicidal behaviour | 11.35 | 10.09 | 19 | 111791 | 2868 | 64384054 |
Dermatitis allergic | 11.35 | 10.09 | 6 | 111804 | 15103 | 64371819 |
Exhibitionism | 11.34 | 10.09 | 4 | 111806 | 47 | 64386875 |
Convulsions local | 11.26 | 10.09 | 4 | 111806 | 48 | 64386874 |
Granuloma | 11.22 | 10.09 | 31 | 111779 | 6610 | 64380312 |
Hypervigilance | 11.21 | 10.09 | 8 | 111802 | 454 | 64386468 |
Enterococcal infection | 11.19 | 10.09 | 5 | 111805 | 13861 | 64373061 |
Paroxysmal arrhythmia | 11.19 | 10.09 | 4 | 111806 | 49 | 64386873 |
Head injury | 11.10 | 10.09 | 96 | 111714 | 32746 | 64354176 |
Cyclothymic disorder | 11.10 | 10.09 | 6 | 111804 | 207 | 64386715 |
Feeling of relaxation | 10.99 | 10.09 | 5 | 111805 | 118 | 64386804 |
Respiratory tract infection | 10.97 | 10.09 | 31 | 111779 | 37376 | 64349546 |
Anhedonia | 10.96 | 10.09 | 50 | 111760 | 13656 | 64373266 |
Job dissatisfaction | 10.90 | 10.09 | 4 | 111806 | 53 | 64386869 |
Normetanephrine urine increased | 10.73 | 10.09 | 3 | 111807 | 15 | 64386907 |
Blood bicarbonate decreased | 10.72 | 10.09 | 25 | 111785 | 4804 | 64382118 |
Hyper IgE syndrome | 10.72 | 10.09 | 8 | 111802 | 487 | 64386435 |
Administration related reaction | 10.69 | 10.09 | 5 | 111805 | 126 | 64386796 |
Knee arthroplasty | 10.68 | 10.09 | 19 | 111791 | 26980 | 64359942 |
Mental status changes | 10.67 | 10.09 | 157 | 111653 | 61005 | 64325917 |
Personality change | 10.67 | 10.09 | 36 | 111774 | 8557 | 64378365 |
Amylase increased | 10.66 | 10.09 | 39 | 111771 | 9646 | 64377276 |
Muscle spasms | 10.65 | 10.09 | 320 | 111490 | 140703 | 64246219 |
Energy increased | 10.65 | 10.09 | 18 | 111792 | 2740 | 64384182 |
Hyperphagia | 10.59 | 10.09 | 16 | 111794 | 2215 | 64384707 |
Bacteraemia | 10.59 | 10.09 | 19 | 111791 | 26892 | 64360030 |
Ankle fracture | 10.56 | 10.09 | 52 | 111758 | 14658 | 64372264 |
Ligament sprain | 10.55 | 10.09 | 42 | 111768 | 10810 | 64376112 |
Influenza | 10.52 | 10.09 | 126 | 111684 | 106405 | 64280517 |
Decreased interest | 10.50 | 10.09 | 20 | 111790 | 3340 | 64383582 |
Skin ulcer | 10.44 | 10.09 | 40 | 111770 | 43934 | 64342988 |
Rebound effect | 10.43 | 10.09 | 25 | 111785 | 4892 | 64382030 |
Accommodation disorder | 10.42 | 10.09 | 8 | 111802 | 508 | 64386414 |
Respiratory distress | 10.35 | 10.09 | 51 | 111759 | 52280 | 64334642 |
Joint range of motion decreased | 10.27 | 10.09 | 11 | 111799 | 19332 | 64367590 |
Visual impairment | 10.25 | 10.09 | 183 | 111627 | 73894 | 64313028 |
Abulia | 10.22 | 10.09 | 10 | 111800 | 881 | 64386041 |
Rash pruritic | 10.21 | 10.09 | 58 | 111752 | 57346 | 64329576 |
Freezing phenomenon | 10.21 | 10.09 | 13 | 111797 | 1533 | 64385389 |
Neurotoxicity | 10.21 | 10.09 | 20 | 111790 | 27384 | 64359538 |
Metastases to lung | 10.15 | 10.09 | 7 | 111803 | 15257 | 64371665 |
None
Source | Code | Description |
---|---|---|
ATC | N06AB05 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:50908 | agente hepatotoxico |
CHEBI has role | CHEBI:50949 | SSRI |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Premenstrual dysphoric disorder | indication | 596004 | |
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Social phobia | indication | 25501002 | DOID:11257 |
Depressive disorder | indication | 35489007 | |
Posttraumatic stress disorder | indication | 47505003 | DOID:2055 |
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Menopausal flushing | indication | 198436008 | |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Mania | contraindication | 231494001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pathological fracture | contraindication | 268029009 | |
Akathisia | contraindication | 285145004 | |
Pregnancy, function | contraindication | 289908002 | |
Serotonin syndrome | contraindication | 371089000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.51 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8946251 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 9393237 | Aug. 4, 2026 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
EQ 7.5MG BASE | BRISDELLE | SEBELA IRELAND LTD | N204516 | June 28, 2013 | RX | CAPSULE | ORAL | 8658663 | April 6, 2029 | TREATMENT OF MODERATE TO SEVERE VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE/5ML | PAROXETINE HYDROCHLORIDE | NOVITIUM PHARMA | A215003 | Sept. 3, 2021 | RX | SUSPENSION | ORAL | March 12, 2022 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 10.40 | CHEMBL | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.65 | DRUG MATRIX | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | Ki | 5.07 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 7.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 4.52 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 5.42 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.46 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.72 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.42 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.47 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.05 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 6.31 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
Cytochrome P450 1A2 | Enzyme | IC50 | 4.96 | WOMBAT-PK | |||||
Substance-P receptor | GPCR | IC50 | 6.05 | CHEMBL | |||||
Myeloperoxidase | Enzyme | IC50 | 7.70 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.86 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.33 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.30 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 7.01 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.48 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 9.36 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.70 | CHEMBL | |||||
Transporter | Transporter | Ki | 7.23 | CHEMBL | |||||
Quinolone resistance protein NorA | Transporter | IC50 | 5.15 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.20 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 5.27 | CHEMBL | |||||
P2X purinoceptor 4 | Ion channel | IC50 | 5.61 | CHEMBL | |||||
Beta-adrenergic receptor kinase 1 | Kinase | IC50 | 5.89 | CHEMBL |
ID | Source |
---|---|
D02260 | KEGG_DRUG |
110429-35-1 | SECONDARY_CAS_RN |
217797-14-3 | SECONDARY_CAS_RN |
78246-49-8 | SECONDARY_CAS_RN |
4020738 | VANDF |
4020815 | VANDF |
C0070122 | UMLSCUI |
CHEBI:7936 | CHEBI |
8PR | PDB_CHEM_ID |
CHEMBL490 | ChEMBL_ID |
CHEMBL4297919 | ChEMBL_ID |
CHEMBL1200609 | ChEMBL_ID |
CHEMBL1708 | ChEMBL_ID |
DB00715 | DRUGBANK_ID |
CHEMBL1256912 | ChEMBL_ID |
D017374 | MESH_DESCRIPTOR_UI |
43815 | PUBCHEM_CID |
4790 | IUPHAR_LIGAND_ID |
4327 | INN_ID |
41VRH5220H | UNII |
114228 | RXNORM |
18339 | MMSL |
205288 | MMSL |
262886 | MMSL |
29631 | MMSL |
4517 | MMSL |
47422 | MMSL |
5236 | MMSL |
d03157 | MMSL |
004016 | NDDF |
004017 | NDDF |
008361 | NDDF |
321963000 | SNOMEDCT_US |
372595009 | SNOMEDCT_US |
411000220105 | SNOMEDCT_US |
420495003 | SNOMEDCT_US |
96214003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7001 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7002 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7004 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0279 | CAPSULE | 7.50 mg | ORAL | NDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7985 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8173 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8174 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 24 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8359 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5676 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5677 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5678 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 31 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5679 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 31 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-433 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-809 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 32 sections |
PAROXETINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-248 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-154 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-155 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 25 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-156 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 25 sections |
Paroxetine | Human Prescription Drug Label | 1 | 13107-157 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 25 sections |
PAROXETINE | Human Prescription Drug Label | 1 | 16590-181 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 25 sections |
PAROXETINE | Human Prescription Drug Label | 1 | 16590-322 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 30 sections |
PAXILCR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-514 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | NDA | 15 sections |
Paroxetine | Human Prescription Drug Label | 1 | 16714-181 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Paroxetine | Human Prescription Drug Label | 1 | 16714-182 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 28 sections |
Paroxetine | Human Prescription Drug Label | 1 | 16714-183 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Paroxetine | Human Prescription Drug Label | 1 | 16714-184 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 28 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-101 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-102 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Paroxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-103 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 22 sections |