paramethadione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2059 115-67-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • paramethadione
  • paradione
  • parametadione
  • Molecular weight: 157.17
  • Formula: C7H11NO3
  • CLOGP: 0.41
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 46.61
  • ALOGS: -0.07
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.90 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 15, 1949 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AC01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Oxazolidine derivatives
CHEBI has role CHEBI:35623 anticonvulsants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated T-type calcium channel Ion channel BLOCKER CHEMBL CHEMBL

External reference:

IDSource
4018716 VUID
N0000147022 NUI
D00495 KEGG_DRUG
4018716 VANDF
C0070072 UMLSCUI
CHEBI:7921 CHEBI
CHEMBL1100 ChEMBL_ID
DB00617 DRUGBANK_ID
8280 PUBCHEM_CID
4163 INN_ID
C005731 MESH_SUPPLEMENTAL_RECORD_UI
7261 IUPHAR_LIGAND_ID
Z615FRW64N UNII
219107 RXNORM
4562 MMSL
5233 MMSL
d00944 MMSL
001628 NDDF
400424004 SNOMEDCT_US
61357000 SNOMEDCT_US

Pharmaceutical products:

None