palmidrol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2045 544-31-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • palmidrol
  • palmitic acid monoethanolamide
  • palmitoylethanolamide
  • palmitic monoethanolamide
a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure
  • Molecular weight: 299.50
  • Formula: C18H37NO2
  • CLOGP: 6
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -5.34
  • ROTB: 16

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:35623 anticonvulsant
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D063386 Cannabinoid Receptor Agonists
MeSH PA D063385 Cannabinoid Receptor Modulators
MeSH PA D002491 Central Nervous System Agents
MeSH PA D006728 Hormones
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cannabinoid receptor 2 GPCR Ki 5.30 PDSP
Cannabinoid receptor 1 GPCR Ki 5.30 PDSP
G-protein coupled receptor 55 GPCR AGONIST EC50 8.40 IUPHAR
Fatty-acid amide hydrolase 1 Enzyme IC50 5.30 CHEMBL

External reference:

IDSource
D08328 KEGG_DRUG
6R8T1UDM3V UNII
871 INN_ID
011010 NDDF
2001986 RXNORM
CHEBI:71464 CHEBI
CHEMBL417675 ChEMBL_ID
4671 PUBCHEM_CID
DB14043 DRUGBANK_ID
C005958 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None