Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastics, taxane derivatives | 2044 | 33069-62-4 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.54 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 6.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 6.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 10, 2019 | EMA | TEVA BV | |
Sept. 20, 2019 | PMDA | Taiho Pharmaceutical Co., Ltd. | |
Dec. 29, 1992 | FDA | HQ SPCLT PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1703.71 | 12.57 | 1431 | 134195 | 66693 | 50402805 |
Neutropenia | 1617.87 | 12.57 | 1985 | 133641 | 145980 | 50323518 |
Neuropathy peripheral | 1503.03 | 12.57 | 1559 | 134067 | 95198 | 50374300 |
Disease progression | 1104.70 | 12.57 | 1322 | 134304 | 94544 | 50374954 |
Metastases to liver | 981.64 | 12.57 | 633 | 134993 | 19471 | 50450027 |
Erythema | 979.41 | 12.57 | 1552 | 134074 | 144862 | 50324636 |
Metastases to bone | 959.42 | 12.57 | 599 | 135027 | 17396 | 50452102 |
Febrile neutropenia | 912.17 | 12.57 | 1213 | 134413 | 96454 | 50373044 |
Flushing | 782.65 | 12.57 | 931 | 134695 | 66084 | 50403414 |
Anaemia | 737.72 | 12.57 | 1894 | 133732 | 250562 | 50218936 |
Drug ineffective | 690.20 | 12.57 | 712 | 134914 | 818621 | 49650877 |
Metastases to lung | 618.18 | 12.57 | 379 | 135247 | 10641 | 50458857 |
Palmar-plantar erythrodysaesthesia syndrome | 611.34 | 12.57 | 474 | 135152 | 19624 | 50449874 |
Dyspnoea | 611.16 | 12.57 | 2986 | 132640 | 544622 | 49924876 |
Neutrophil count decreased | 591.64 | 12.57 | 672 | 134954 | 45354 | 50424144 |
Polyneuropathy | 540.93 | 12.57 | 361 | 135265 | 11770 | 50457728 |
Myelosuppression | 524.08 | 12.57 | 369 | 135257 | 13148 | 50456350 |
Peripheral sensory neuropathy | 500.59 | 12.57 | 276 | 135350 | 6315 | 50463183 |
Neoplasm progression | 481.00 | 12.57 | 486 | 135140 | 28671 | 50440827 |
Metastases to central nervous system | 474.98 | 12.57 | 324 | 135302 | 10958 | 50458540 |
Joint swelling | 464.80 | 12.57 | 56 | 135570 | 245230 | 50224268 |
Rheumatoid arthritis | 464.55 | 12.57 | 18 | 135608 | 202532 | 50266966 |
Acute myeloid leukaemia | 439.97 | 12.57 | 347 | 135279 | 14727 | 50454771 |
Thrombocytopenia | 428.12 | 12.57 | 1011 | 134615 | 126662 | 50342836 |
Neurotoxicity | 414.56 | 12.57 | 332 | 135294 | 14408 | 50455090 |
Mucosal inflammation | 404.35 | 12.57 | 518 | 135108 | 39624 | 50429874 |
Leukopenia | 403.35 | 12.57 | 681 | 134945 | 66847 | 50402651 |
Metastases to lymph nodes | 402.70 | 12.57 | 245 | 135381 | 6779 | 50462719 |
Pneumonitis | 375.93 | 12.57 | 429 | 135197 | 29081 | 50440417 |
Ejection fraction decreased | 375.80 | 12.57 | 346 | 135280 | 18174 | 50451324 |
Chest discomfort | 366.34 | 12.57 | 784 | 134842 | 91938 | 50377560 |
Product dose omission issue | 360.68 | 12.57 | 37 | 135589 | 183801 | 50285697 |
Ascites | 352.14 | 12.57 | 457 | 135169 | 35404 | 50434094 |
Death | 351.61 | 12.57 | 1761 | 133865 | 323618 | 50145880 |
Haematotoxicity | 349.69 | 12.57 | 234 | 135392 | 7661 | 50461837 |
Contraindicated product administered | 345.72 | 12.57 | 12 | 135614 | 148946 | 50320552 |
Fall | 334.79 | 12.57 | 246 | 135380 | 334686 | 50134812 |
Completed suicide | 332.00 | 12.57 | 4 | 135622 | 131885 | 50337613 |
Bone marrow failure | 322.50 | 12.57 | 384 | 135242 | 27240 | 50442258 |
Arthropathy | 319.74 | 12.57 | 28 | 135598 | 157878 | 50311620 |
Systemic lupus erythematosus | 298.63 | 12.57 | 20 | 135606 | 140602 | 50328896 |
Synovitis | 290.88 | 12.57 | 9 | 135617 | 123856 | 50345642 |
Sinusitis | 288.37 | 12.57 | 54 | 135572 | 170504 | 50298994 |
Therapeutic product effect decreased | 284.12 | 12.57 | 21 | 135605 | 136029 | 50333469 |
Cystoid macular oedema | 272.25 | 12.57 | 112 | 135514 | 1287 | 50468211 |
Proteinuria | 270.65 | 12.57 | 275 | 135351 | 16322 | 50453176 |
Anaphylactic shock | 270.30 | 12.57 | 301 | 135325 | 19854 | 50449644 |
Abdominal discomfort | 270.19 | 12.57 | 142 | 135484 | 231499 | 50237999 |
Weight increased | 266.28 | 12.57 | 104 | 135522 | 201787 | 50267711 |
Glossodynia | 262.35 | 12.57 | 11 | 135615 | 115558 | 50353940 |
Pseudocirrhosis | 261.63 | 12.57 | 88 | 135538 | 542 | 50468956 |
Feeling hot | 257.76 | 12.57 | 413 | 135213 | 38789 | 50430709 |
Condition aggravated | 257.67 | 12.57 | 250 | 135376 | 296808 | 50172690 |
Headache | 253.67 | 12.57 | 620 | 135006 | 505915 | 49963583 |
Breast cancer metastatic | 252.89 | 12.57 | 215 | 135411 | 10149 | 50459349 |
Metastases to peritoneum | 246.89 | 12.57 | 130 | 135496 | 2703 | 50466795 |
Hypertension | 246.19 | 12.57 | 1169 | 134457 | 210034 | 50259464 |
Pain | 245.03 | 12.57 | 769 | 134857 | 578134 | 49891364 |
Epistaxis | 242.44 | 12.57 | 532 | 135094 | 63422 | 50406076 |
Swelling | 241.90 | 12.57 | 118 | 135508 | 200754 | 50268744 |
General physical health deterioration | 241.83 | 12.57 | 885 | 134741 | 141549 | 50327949 |
Second primary malignancy | 238.81 | 12.57 | 176 | 135450 | 6738 | 50462760 |
Interstitial lung disease | 237.35 | 12.57 | 473 | 135153 | 52703 | 50416795 |
Pleural effusion | 236.72 | 12.57 | 611 | 135015 | 80843 | 50388655 |
Onycholysis | 230.51 | 12.57 | 98 | 135528 | 1230 | 50468268 |
Skin toxicity | 225.61 | 12.57 | 137 | 135489 | 3776 | 50465722 |
Bronchospasm | 216.87 | 12.57 | 232 | 135394 | 14622 | 50454876 |
Myelodysplastic syndrome | 216.82 | 12.57 | 234 | 135392 | 14898 | 50454600 |
Musculoskeletal stiffness | 216.43 | 12.57 | 41 | 135585 | 128440 | 50341058 |
Gastrointestinal perforation | 215.58 | 12.57 | 122 | 135504 | 2939 | 50466559 |
Product use issue | 200.34 | 12.57 | 75 | 135551 | 149400 | 50320098 |
Ovarian cancer recurrent | 197.11 | 12.57 | 78 | 135548 | 804 | 50468694 |
Injection site pain | 196.71 | 12.57 | 31 | 135595 | 110993 | 50358505 |
Drug intolerance | 189.13 | 12.57 | 185 | 135441 | 218919 | 50250579 |
Vomiting | 186.54 | 12.57 | 1969 | 133657 | 458789 | 50010709 |
Back pain | 185.97 | 12.57 | 1115 | 134511 | 218915 | 50250583 |
Peripheral swelling | 176.44 | 12.57 | 175 | 135451 | 205761 | 50263737 |
Hypertransaminasaemia | 174.42 | 12.57 | 113 | 135513 | 3498 | 50466000 |
Diarrhoea | 169.39 | 12.57 | 2357 | 133269 | 586119 | 49883379 |
Cardiac dysfunction | 168.26 | 12.57 | 85 | 135541 | 1616 | 50467882 |
Bone pain | 163.46 | 12.57 | 379 | 135247 | 46850 | 50422648 |
Nausea | 160.36 | 12.57 | 2714 | 132912 | 702684 | 49766814 |
Pyrexia | 159.45 | 12.57 | 1637 | 133989 | 378566 | 50090932 |
Treatment failure | 155.06 | 12.57 | 88 | 135538 | 137549 | 50331949 |
Wound | 154.09 | 12.57 | 46 | 135580 | 105748 | 50363750 |
Embolism | 152.75 | 12.57 | 136 | 135490 | 6832 | 50462666 |
Arthralgia | 152.52 | 12.57 | 632 | 134994 | 438070 | 50031428 |
Sense of oppression | 151.73 | 12.57 | 66 | 135560 | 879 | 50468619 |
Nasopharyngitis | 150.74 | 12.57 | 177 | 135449 | 192750 | 50276748 |
Abdominal pain | 148.89 | 12.57 | 1113 | 134513 | 235115 | 50234383 |
Platelet count decreased | 148.76 | 12.57 | 599 | 135027 | 100127 | 50369371 |
Osteonecrosis of jaw | 143.50 | 12.57 | 288 | 135338 | 32238 | 50437260 |
Drug abuse | 141.72 | 12.57 | 4 | 135622 | 59842 | 50409656 |
Somnolence | 140.58 | 12.57 | 125 | 135501 | 154860 | 50314638 |
Psoriasis | 140.22 | 12.57 | 12 | 135614 | 68988 | 50400510 |
White blood cell count decreased | 140.08 | 12.57 | 652 | 134974 | 116070 | 50353428 |
Lymphangiosis carcinomatosa | 139.89 | 12.57 | 67 | 135559 | 1129 | 50468369 |
Injection site erythema | 139.54 | 12.57 | 18 | 135608 | 74918 | 50394580 |
PIK3CA-activated mutation | 138.03 | 12.57 | 59 | 135567 | 751 | 50468747 |
Hospitalisation | 137.55 | 12.57 | 12 | 135614 | 67925 | 50401573 |
Breast cancer recurrent | 136.18 | 12.57 | 99 | 135527 | 3709 | 50465789 |
Overdose | 135.33 | 12.57 | 49 | 135577 | 99678 | 50369820 |
Metastasis | 134.75 | 12.57 | 104 | 135522 | 4271 | 50465227 |
Drug hypersensitivity | 134.24 | 12.57 | 296 | 135330 | 250714 | 50218784 |
Cardiotoxicity | 130.46 | 12.57 | 125 | 135501 | 6902 | 50462596 |
Nail disorder | 130.17 | 12.57 | 145 | 135481 | 9563 | 50459935 |
Hepatic enzyme increased | 129.22 | 12.57 | 107 | 135519 | 137273 | 50332225 |
Migraine | 124.67 | 12.57 | 25 | 135601 | 75255 | 50394243 |
Suicide attempt | 124.21 | 12.57 | 3 | 135623 | 51729 | 50417769 |
Arthritis | 123.94 | 12.57 | 39 | 135587 | 86682 | 50382816 |
Paraesthesia | 122.43 | 12.57 | 641 | 134985 | 119602 | 50349896 |
Maternal exposure during pregnancy | 122.21 | 12.57 | 149 | 135477 | 159629 | 50309869 |
Contusion | 121.71 | 12.57 | 75 | 135551 | 112108 | 50357390 |
Mobility decreased | 119.66 | 12.57 | 33 | 135593 | 79915 | 50389583 |
Depression | 119.56 | 12.57 | 161 | 135465 | 165262 | 50304236 |
Tachycardia | 119.48 | 12.57 | 557 | 135069 | 99206 | 50370292 |
Hypokalaemia | 119.48 | 12.57 | 510 | 135116 | 87482 | 50382016 |
Pericarditis | 118.67 | 12.57 | 32 | 135594 | 78657 | 50390841 |
Therapy partial responder | 118.14 | 12.57 | 115 | 135511 | 6476 | 50463022 |
Blood cholesterol increased | 116.71 | 12.57 | 8 | 135618 | 55207 | 50414291 |
Loss of personal independence in daily activities | 116.55 | 12.57 | 23 | 135603 | 70027 | 50399471 |
Irritable bowel syndrome | 116.35 | 12.57 | 5 | 135621 | 51436 | 50418062 |
Pulmonary embolism | 116.09 | 12.57 | 560 | 135066 | 101144 | 50368354 |
Exposure during pregnancy | 115.36 | 12.57 | 93 | 135533 | 120922 | 50348576 |
Helicobacter infection | 115.25 | 12.57 | 4 | 135622 | 49698 | 50419800 |
Metastases to meninges | 115.18 | 12.57 | 70 | 135556 | 1932 | 50467566 |
Oxygen saturation decreased | 114.90 | 12.57 | 444 | 135182 | 72804 | 50396694 |
Large intestine perforation | 114.63 | 12.57 | 120 | 135506 | 7374 | 50462124 |
Nail discolouration | 114.52 | 12.57 | 74 | 135552 | 2280 | 50467218 |
Peripheral motor neuropathy | 114.39 | 12.57 | 62 | 135564 | 1369 | 50468129 |
Left ventricular dysfunction | 114.35 | 12.57 | 141 | 135485 | 10365 | 50459133 |
Gastrointestinal toxicity | 114.04 | 12.57 | 97 | 135529 | 4580 | 50464918 |
Hypoxia | 111.69 | 12.57 | 346 | 135280 | 50777 | 50418721 |
Influenza | 111.68 | 12.57 | 50 | 135576 | 89488 | 50380010 |
Disease recurrence | 108.65 | 12.57 | 194 | 135432 | 19887 | 50449611 |
Asthenia | 107.28 | 12.57 | 1316 | 134310 | 317726 | 50151772 |
Pneumocystis jirovecii pneumonia | 106.81 | 12.57 | 162 | 135464 | 14501 | 50454997 |
Dehydration | 106.15 | 12.57 | 736 | 134890 | 151713 | 50317785 |
Neutropenic sepsis | 105.47 | 12.57 | 158 | 135468 | 13989 | 50455509 |
Toxicity to various agents | 105.22 | 12.57 | 261 | 135365 | 212238 | 50257260 |
Nail toxicity | 104.68 | 12.57 | 38 | 135588 | 302 | 50469196 |
Drug interaction | 101.33 | 12.57 | 242 | 135384 | 199379 | 50270119 |
Hepatic atrophy | 100.73 | 12.57 | 35 | 135591 | 241 | 50469257 |
Decreased appetite | 100.21 | 12.57 | 898 | 134728 | 200025 | 50269473 |
Throat tightness | 99.72 | 12.57 | 191 | 135435 | 20656 | 50448842 |
Fibromyalgia | 99.68 | 12.57 | 5 | 135621 | 44973 | 50424525 |
Biliary tract infection | 98.63 | 12.57 | 39 | 135587 | 401 | 50469097 |
Duodenal ulcer perforation | 98.21 | 12.57 | 6 | 135620 | 45605 | 50423893 |
Injection site reaction | 98.19 | 12.57 | 10 | 135616 | 50022 | 50419476 |
Urogenital fistula | 98.08 | 12.57 | 29 | 135597 | 108 | 50469390 |
Inappropriate schedule of product administration | 97.94 | 12.57 | 35 | 135591 | 71796 | 50397702 |
Asthma | 97.91 | 12.57 | 59 | 135567 | 89278 | 50380220 |
Hepatic failure | 96.63 | 12.57 | 245 | 135381 | 32038 | 50437460 |
Feeling abnormal | 94.91 | 12.57 | 118 | 135508 | 125374 | 50344124 |
Cyanosis | 94.37 | 12.57 | 156 | 135470 | 15028 | 50454470 |
Ileus | 93.32 | 12.57 | 144 | 135482 | 13085 | 50456413 |
Discomfort | 92.84 | 12.57 | 92 | 135534 | 108288 | 50361210 |
Injection site swelling | 91.45 | 12.57 | 5 | 135621 | 41768 | 50427730 |
Intestinal perforation | 91.25 | 12.57 | 126 | 135500 | 10353 | 50459145 |
Insomnia | 90.32 | 12.57 | 210 | 135416 | 174655 | 50294843 |
Lower respiratory tract infection | 89.67 | 12.57 | 74 | 135552 | 95127 | 50374371 |
Metastases to skin | 89.05 | 12.57 | 52 | 135574 | 1331 | 50468167 |
Memory impairment | 88.96 | 12.57 | 51 | 135575 | 79309 | 50390189 |
Dysaesthesia | 88.09 | 12.57 | 76 | 135550 | 3659 | 50465839 |
Injection site pruritus | 87.97 | 12.57 | 5 | 135621 | 40406 | 50429092 |
Confusional state | 86.18 | 12.57 | 236 | 135390 | 185692 | 50283806 |
Cardiomyopathy | 86.15 | 12.57 | 152 | 135474 | 15434 | 50454064 |
Cholangitis | 86.04 | 12.57 | 82 | 135544 | 4497 | 50465001 |
Laryngospasm | 85.20 | 12.57 | 65 | 135561 | 2623 | 50466875 |
Incorrect dose administered | 84.63 | 12.57 | 14 | 135612 | 48400 | 50421098 |
Gait disturbance | 82.50 | 12.57 | 174 | 135452 | 149831 | 50319667 |
Tumour necrosis | 82.46 | 12.57 | 40 | 135586 | 694 | 50468804 |
Subileus | 81.53 | 12.57 | 64 | 135562 | 2695 | 50466803 |
Intentional product misuse | 80.62 | 12.57 | 14 | 135612 | 46720 | 50422778 |
Recall phenomenon | 80.14 | 12.57 | 36 | 135590 | 520 | 50468978 |
Osteoarthritis | 79.93 | 12.57 | 42 | 135584 | 68564 | 50400934 |
Tumour haemorrhage | 79.55 | 12.57 | 48 | 135578 | 1307 | 50468191 |
Posterior reversible encephalopathy syndrome | 77.92 | 12.57 | 142 | 135484 | 14786 | 50454712 |
Suicidal ideation | 77.20 | 12.57 | 26 | 135600 | 55359 | 50414139 |
Pancytopenia | 76.74 | 12.57 | 435 | 135191 | 83595 | 50385903 |
Muscle spasms | 76.53 | 12.57 | 137 | 135489 | 125416 | 50344082 |
Acute promyelocytic leukaemia | 75.43 | 12.57 | 40 | 135586 | 844 | 50468654 |
Small intestinal obstruction | 75.36 | 12.57 | 146 | 135480 | 15922 | 50453576 |
Injury | 73.56 | 12.57 | 20 | 135606 | 48905 | 50420593 |
Hypersensitivity | 73.26 | 12.57 | 890 | 134736 | 214271 | 50255227 |
Tumour marker increased | 72.60 | 12.57 | 69 | 135557 | 3771 | 50465727 |
Metastases to spine | 71.67 | 12.57 | 60 | 135566 | 2771 | 50466727 |
Metastases to pleura | 70.89 | 12.57 | 44 | 135582 | 1262 | 50468236 |
Hypoglycaemia | 69.88 | 12.57 | 28 | 135598 | 53553 | 50415945 |
Anaphylactoid reaction | 69.78 | 12.57 | 64 | 135562 | 3342 | 50466156 |
Hydronephrosis | 68.89 | 12.57 | 99 | 135527 | 8442 | 50461056 |
Malignant pleural effusion | 68.75 | 12.57 | 54 | 135572 | 2276 | 50467222 |
Metastatic neoplasm | 68.22 | 12.57 | 66 | 135560 | 3688 | 50465810 |
Blister | 68.11 | 12.57 | 77 | 135549 | 85341 | 50384157 |
Cardiac failure | 67.05 | 12.57 | 390 | 135236 | 75650 | 50393848 |
Carbohydrate antigen 15-3 increased | 66.20 | 12.57 | 40 | 135586 | 1092 | 50468406 |
Red blood cell sedimentation rate increased | 66.05 | 12.57 | 3 | 135623 | 29413 | 50440085 |
Fluid retention | 65.18 | 12.57 | 27 | 135599 | 50622 | 50418876 |
Abortion spontaneous | 64.86 | 12.57 | 16 | 135610 | 41756 | 50427742 |
Alveolitis | 64.76 | 12.57 | 54 | 135572 | 2480 | 50467018 |
Metastases to the mediastinum | 63.22 | 12.57 | 29 | 135597 | 441 | 50469057 |
Therapeutic product effect incomplete | 63.14 | 12.57 | 92 | 135534 | 91423 | 50378075 |
Osteoporosis | 62.67 | 12.57 | 21 | 135605 | 44858 | 50424640 |
C-reactive protein abnormal | 61.91 | 12.57 | 3 | 135623 | 27806 | 50441692 |
Pneumothorax | 61.57 | 12.57 | 124 | 135502 | 13910 | 50455588 |
Bronchitis | 61.39 | 12.57 | 116 | 135510 | 104043 | 50365455 |
Metastases to retroperitoneum | 61.02 | 12.57 | 21 | 135605 | 140 | 50469358 |
Bronchostenosis | 60.17 | 12.57 | 27 | 135599 | 389 | 50469109 |
Infusion related reaction | 60.15 | 12.57 | 707 | 134919 | 168850 | 50300648 |
Hypertensive crisis | 59.84 | 12.57 | 118 | 135508 | 13036 | 50456462 |
Anxiety | 58.94 | 12.57 | 260 | 135366 | 177346 | 50292152 |
Computerised tomogram thorax abnormal | 58.86 | 12.57 | 40 | 135586 | 1343 | 50468155 |
Portal hypertension | 58.58 | 12.57 | 58 | 135568 | 3334 | 50466164 |
Performance status decreased | 57.73 | 12.57 | 56 | 135570 | 3139 | 50466359 |
Secondary cerebellar degeneration | 57.25 | 12.57 | 16 | 135610 | 46 | 50469452 |
Metastases to kidney | 57.19 | 12.57 | 21 | 135605 | 173 | 50469325 |
Hepatic function abnormal | 56.96 | 12.57 | 205 | 135421 | 32476 | 50437022 |
Pain in extremity | 56.93 | 12.57 | 463 | 135163 | 272402 | 50197096 |
Anaphylactic reaction | 56.92 | 12.57 | 291 | 135335 | 53764 | 50415734 |
Surgery | 56.84 | 12.57 | 7 | 135619 | 30198 | 50439300 |
Paronychia | 55.81 | 12.57 | 65 | 135561 | 4499 | 50464999 |
Carbohydrate antigen 125 increased | 55.76 | 12.57 | 49 | 135577 | 2418 | 50467080 |
Coronary artery disease | 55.66 | 12.57 | 7 | 135619 | 29719 | 50439779 |
Unevaluable event | 55.45 | 12.57 | 27 | 135599 | 46039 | 50423459 |
Adverse event | 55.24 | 12.57 | 24 | 135602 | 43739 | 50425759 |
Hyperaemia | 55.13 | 12.57 | 45 | 135581 | 2005 | 50467493 |
Irritability | 54.95 | 12.57 | 6 | 135620 | 28420 | 50441078 |
Chronic obstructive pulmonary disease | 54.84 | 12.57 | 38 | 135588 | 53397 | 50416101 |
Urinary tract obstruction | 54.81 | 12.57 | 42 | 135584 | 1706 | 50467792 |
Stomatitis | 54.63 | 12.57 | 461 | 135165 | 100883 | 50368615 |
Recurrent cancer | 54.62 | 12.57 | 42 | 135584 | 1715 | 50467783 |
Folliculitis | 53.65 | 12.57 | 19 | 135607 | 39206 | 50430292 |
Cataract | 53.57 | 12.57 | 30 | 135596 | 47270 | 50422228 |
Illness | 53.52 | 12.57 | 3 | 135623 | 24537 | 50444961 |
Macular oedema | 53.20 | 12.57 | 57 | 135569 | 3597 | 50465901 |
Plasma cell myeloma | 52.69 | 12.57 | 10 | 135616 | 31312 | 50438186 |
Urticaria | 52.43 | 12.57 | 175 | 135451 | 129386 | 50340112 |
Palmar erythema | 52.21 | 12.57 | 39 | 135587 | 1524 | 50467974 |
Small intestinal perforation | 51.61 | 12.57 | 36 | 135590 | 1262 | 50468236 |
Blood pressure fluctuation | 51.36 | 12.57 | 16 | 135610 | 35807 | 50433691 |
Atelectasis | 50.91 | 12.57 | 135 | 135491 | 18135 | 50451363 |
Gastric disorder | 50.64 | 12.57 | 9 | 135617 | 29539 | 50439959 |
Hepatic lesion | 50.56 | 12.57 | 58 | 135568 | 3950 | 50465548 |
Bile duct stenosis | 50.32 | 12.57 | 33 | 135593 | 1043 | 50468455 |
Drug reaction with eosinophilia and systemic symptoms | 50.17 | 12.57 | 8 | 135618 | 28416 | 50441082 |
Carcinoembryonic antigen increased | 49.73 | 12.57 | 37 | 135589 | 1437 | 50468061 |
Pleural neoplasm | 49.30 | 12.57 | 20 | 135606 | 221 | 50469277 |
Lymphoedema | 49.17 | 12.57 | 88 | 135538 | 9034 | 50460464 |
Coma | 49.01 | 12.57 | 48 | 135578 | 56831 | 50412667 |
Nephrolithiasis | 48.85 | 12.57 | 16 | 135610 | 34677 | 50434821 |
Device related infection | 48.71 | 12.57 | 144 | 135482 | 20591 | 50448907 |
Cholangitis sclerosing | 48.66 | 12.57 | 34 | 135592 | 1195 | 50468303 |
Tumour lysis syndrome | 48.49 | 12.57 | 78 | 135548 | 7343 | 50462155 |
Radiation pneumonitis | 48.40 | 12.57 | 35 | 135591 | 1300 | 50468198 |
Bone lesion | 47.80 | 12.57 | 64 | 135562 | 5106 | 50464392 |
Dizziness | 47.66 | 12.57 | 648 | 134978 | 345721 | 50123777 |
Sleep disorder | 47.47 | 12.57 | 50 | 135576 | 57233 | 50412265 |
Eczema asteatotic | 47.47 | 12.57 | 20 | 135606 | 245 | 50469253 |
Malignant ascites | 46.96 | 12.57 | 29 | 135597 | 824 | 50468674 |
Medication error | 46.86 | 12.57 | 19 | 135607 | 36085 | 50433413 |
Hallucination | 46.80 | 12.57 | 34 | 135592 | 46623 | 50422875 |
Pregnancy | 46.56 | 12.57 | 11 | 135615 | 29566 | 50439932 |
Ear infection | 46.54 | 12.57 | 7 | 135619 | 25963 | 50443535 |
Capillary leak syndrome | 45.67 | 12.57 | 39 | 135587 | 1851 | 50467647 |
Wrong technique in product usage process | 45.39 | 12.57 | 49 | 135577 | 55461 | 50414037 |
Subclavian vein thrombosis | 45.28 | 12.57 | 38 | 135588 | 1761 | 50467737 |
Pericardial effusion | 45.01 | 12.57 | 161 | 135465 | 25428 | 50444070 |
Basal cell carcinoma | 44.97 | 12.57 | 5 | 135621 | 23351 | 50446147 |
Superior vena cava syndrome | 44.82 | 12.57 | 25 | 135601 | 585 | 50468913 |
Biliary sepsis | 44.53 | 12.57 | 28 | 135598 | 822 | 50468676 |
Device related thrombosis | 44.52 | 12.57 | 33 | 135593 | 1274 | 50468224 |
Swollen tongue | 44.38 | 12.57 | 11 | 135615 | 28619 | 50440879 |
Metastases to pelvis | 44.38 | 12.57 | 21 | 135605 | 344 | 50469154 |
Acute interstitial pneumonitis | 44.33 | 12.57 | 25 | 135601 | 598 | 50468900 |
Nervousness | 44.09 | 12.57 | 10 | 135616 | 27641 | 50441857 |
Constipation | 43.74 | 12.57 | 720 | 134906 | 184988 | 50284510 |
Neoplasm recurrence | 43.71 | 12.57 | 42 | 135584 | 2327 | 50467171 |
Serotonin syndrome | 43.52 | 12.57 | 7 | 135619 | 24706 | 50444792 |
Type I hypersensitivity | 43.47 | 12.57 | 42 | 135584 | 2343 | 50467155 |
Colitis | 43.08 | 12.57 | 211 | 135415 | 38318 | 50431180 |
Nasal congestion | 43.06 | 12.57 | 44 | 135582 | 51076 | 50418422 |
Crying | 43.02 | 12.57 | 3 | 135623 | 20413 | 50449085 |
Pulmonary arterial hypertension | 42.77 | 12.57 | 3 | 135623 | 20316 | 50449182 |
Sepsis | 42.66 | 12.57 | 544 | 135082 | 132381 | 50337117 |
Intestinal obstruction | 42.22 | 12.57 | 161 | 135465 | 26222 | 50443276 |
Oesophagobronchial fistula | 42.07 | 12.57 | 12 | 135614 | 38 | 50469460 |
Metastases to chest wall | 41.84 | 12.57 | 22 | 135604 | 456 | 50469042 |
COVID-19 | 41.82 | 12.57 | 38 | 135588 | 46624 | 50422874 |
Drug dependence | 41.35 | 12.57 | 3 | 135623 | 19756 | 50449742 |
Myocardial infarction | 41.20 | 12.57 | 113 | 135513 | 88914 | 50380584 |
Hot flush | 41.19 | 12.57 | 230 | 135396 | 43939 | 50425559 |
Endocarditis noninfective | 41.16 | 12.57 | 12 | 135614 | 42 | 50469456 |
Cerebrovascular accident | 41.02 | 12.57 | 124 | 135502 | 94556 | 50374942 |
Toxic erythema of chemotherapy | 41.02 | 12.57 | 15 | 135611 | 122 | 50469376 |
Dyskinesia | 40.75 | 12.57 | 12 | 135614 | 27849 | 50441649 |
Acute myelomonocytic leukaemia | 40.68 | 12.57 | 16 | 135610 | 162 | 50469336 |
Adverse drug reaction | 40.61 | 12.57 | 53 | 135573 | 55169 | 50414329 |
Rash pruritic | 40.51 | 12.57 | 41 | 135585 | 47805 | 50421693 |
Multiple sclerosis | 40.45 | 12.57 | 4 | 135622 | 20489 | 50449009 |
Dysgeusia | 39.92 | 12.57 | 208 | 135418 | 38708 | 50430790 |
Extravasation | 39.81 | 12.57 | 37 | 135589 | 1965 | 50467533 |
Rhabdomyolysis | 39.72 | 12.57 | 28 | 135598 | 38999 | 50430499 |
Periodontitis | 39.71 | 12.57 | 45 | 135581 | 3024 | 50466474 |
Blood uric acid decreased | 39.63 | 12.57 | 24 | 135602 | 658 | 50468840 |
Hip arthroplasty | 39.51 | 12.57 | 16 | 135610 | 30413 | 50439085 |
Hypervolaemia | 39.13 | 12.57 | 10 | 135616 | 25489 | 50444009 |
Aortitis | 38.98 | 12.57 | 26 | 135600 | 846 | 50468652 |
Thrombotic microangiopathy | 38.95 | 12.57 | 78 | 135548 | 8713 | 50460785 |
Gastrooesophageal reflux disease | 38.45 | 12.57 | 93 | 135533 | 76335 | 50393163 |
Administration site extravasation | 38.40 | 12.57 | 24 | 135602 | 697 | 50468801 |
Transaminases increased | 38.29 | 12.57 | 162 | 135464 | 27662 | 50441836 |
Hyperpyrexia | 38.25 | 12.57 | 44 | 135582 | 3005 | 50466493 |
Diabetes mellitus | 38.22 | 12.57 | 45 | 135581 | 48988 | 50420510 |
Lymphadenopathy mediastinal | 38.03 | 12.57 | 40 | 135586 | 2471 | 50467027 |
Pseudomembranous colitis | 38.03 | 12.57 | 42 | 135584 | 2743 | 50466755 |
Lactic acidosis | 37.99 | 12.57 | 21 | 135605 | 33334 | 50436164 |
Female genital tract fistula | 37.97 | 12.57 | 48 | 135578 | 3618 | 50465880 |
Peritonitis | 37.77 | 12.57 | 109 | 135517 | 15377 | 50454121 |
Fistula | 37.72 | 12.57 | 74 | 135552 | 8144 | 50461354 |
International normalised ratio increased | 37.66 | 12.57 | 36 | 135590 | 43116 | 50426382 |
Suffocation feeling | 37.23 | 12.57 | 29 | 135597 | 1207 | 50468291 |
Cachexia | 37.23 | 12.57 | 53 | 135573 | 4480 | 50465018 |
Capillary permeability increased | 37.07 | 12.57 | 10 | 135616 | 24 | 50469474 |
Hypersensitivity pneumonitis | 36.98 | 12.57 | 38 | 135588 | 2284 | 50467214 |
Psychotic disorder | 36.61 | 12.57 | 7 | 135619 | 21805 | 50447693 |
Road traffic accident | 36.52 | 12.57 | 10 | 135616 | 24342 | 50445156 |
Radiation necrosis | 36.46 | 12.57 | 18 | 135608 | 325 | 50469173 |
Lymphocele | 36.33 | 12.57 | 24 | 135602 | 768 | 50468730 |
Stress | 36.20 | 12.57 | 55 | 135571 | 53738 | 50415760 |
Hypoalbuminaemia | 36.17 | 12.57 | 81 | 135545 | 9779 | 50459719 |
Deep vein thrombosis | 36.13 | 12.57 | 327 | 135299 | 72977 | 50396521 |
Metastases to stomach | 36.03 | 12.57 | 15 | 135611 | 178 | 50469320 |
Anastomotic leak | 35.99 | 12.57 | 19 | 135607 | 397 | 50469101 |
Hormone receptor positive breast cancer | 35.93 | 12.57 | 20 | 135606 | 466 | 50469032 |
Tremor | 35.84 | 12.57 | 172 | 135454 | 114731 | 50354767 |
Gait inability | 35.83 | 12.57 | 28 | 135598 | 36999 | 50432499 |
Wheezing | 35.76 | 12.57 | 70 | 135556 | 61977 | 50407521 |
Drug resistance | 35.58 | 12.57 | 122 | 135504 | 18867 | 50450631 |
Metastases to soft tissue | 35.23 | 12.57 | 14 | 135612 | 146 | 50469352 |
Bradycardia | 35.16 | 12.57 | 75 | 135551 | 64351 | 50405147 |
Limb injury | 35.07 | 12.57 | 6 | 135620 | 20244 | 50449254 |
Therapy interrupted | 34.83 | 12.57 | 6 | 135620 | 20146 | 50449352 |
Enterocolitis infectious | 34.70 | 12.57 | 30 | 135596 | 1448 | 50468050 |
Disseminated intravascular coagulation | 34.69 | 12.57 | 113 | 135513 | 17022 | 50452476 |
Product prescribing error | 34.61 | 12.57 | 7 | 135619 | 20954 | 50448544 |
Primary cardiac lymphoma | 34.48 | 12.57 | 9 | 135617 | 18 | 50469480 |
Metastases to abdominal wall | 34.37 | 12.57 | 12 | 135614 | 84 | 50469414 |
Respiratory distress | 34.11 | 12.57 | 167 | 135459 | 30322 | 50439176 |
Neutropenic colitis | 33.96 | 12.57 | 37 | 135589 | 2380 | 50467118 |
Laboratory test abnormal | 33.93 | 12.57 | 10 | 135616 | 23198 | 50446300 |
Onychalgia | 33.85 | 12.57 | 23 | 135603 | 772 | 50468726 |
Gallbladder disorder | 33.76 | 12.57 | 3 | 135623 | 16739 | 50452759 |
Scleroderma-like reaction | 33.67 | 12.57 | 11 | 135615 | 61 | 50469437 |
Metastases to breast | 33.54 | 12.57 | 16 | 135610 | 267 | 50469231 |
Injection site haemorrhage | 33.48 | 12.57 | 8 | 135618 | 21338 | 50448160 |
Blood glucose increased | 33.40 | 12.57 | 90 | 135536 | 71234 | 50398264 |
Mental disorder | 33.03 | 12.57 | 9 | 135617 | 21982 | 50447516 |
Hypocalcaemia | 33 | 12.57 | 151 | 135475 | 26665 | 50442833 |
Bronchial fistula | 32.97 | 12.57 | 9 | 135617 | 23 | 50469475 |
Hepatitis B reactivation | 32.96 | 12.57 | 34 | 135592 | 2053 | 50467445 |
Hypomagnesaemia | 32.78 | 12.57 | 136 | 135490 | 23020 | 50446478 |
Breast cancer | 32.75 | 12.57 | 212 | 135414 | 42678 | 50426820 |
Amnesia | 32.70 | 12.57 | 39 | 135587 | 42221 | 50427277 |
Herpes zoster | 32.64 | 12.57 | 90 | 135536 | 70696 | 50398802 |
Eye pain | 32.27 | 12.57 | 18 | 135608 | 28431 | 50441067 |
Eosinophil percentage increased | 32.21 | 12.57 | 24 | 135602 | 934 | 50468564 |
Radiation skin injury | 32.15 | 12.57 | 23 | 135603 | 840 | 50468658 |
Dyspnoea at rest | 31.97 | 12.57 | 44 | 135582 | 3603 | 50465895 |
Peritoneal disorder | 31.94 | 12.57 | 18 | 135608 | 430 | 50469068 |
Joint stiffness | 31.83 | 12.57 | 21 | 135605 | 30287 | 50439211 |
Renal disorder | 31.79 | 12.57 | 17 | 135609 | 27488 | 50442010 |
No adverse event | 31.73 | 12.57 | 26 | 135600 | 33552 | 50435946 |
Product administration error | 31.66 | 12.57 | 7 | 135619 | 19692 | 50449806 |
Chills | 31.56 | 12.57 | 397 | 135229 | 96290 | 50373208 |
Treatment noncompliance | 31.52 | 12.57 | 21 | 135605 | 30129 | 50439369 |
Adenocarcinoma | 31.46 | 12.57 | 36 | 135590 | 2445 | 50467053 |
Acne | 31.42 | 12.57 | 7 | 135619 | 19588 | 50449910 |
Metabolic acidosis | 30.94 | 12.57 | 35 | 135591 | 38790 | 50430708 |
Type 2 diabetes mellitus | 30.80 | 12.57 | 28 | 135598 | 34347 | 50435151 |
Head injury | 30.59 | 12.57 | 13 | 135613 | 24007 | 50445491 |
Tonsillar disorder | 30.58 | 12.57 | 24 | 135602 | 1010 | 50468488 |
Oesophagitis | 30.54 | 12.57 | 92 | 135534 | 13291 | 50456207 |
Tumour embolism | 30.47 | 12.57 | 12 | 135614 | 122 | 50469376 |
Choking sensation | 30.37 | 12.57 | 40 | 135586 | 3140 | 50466358 |
Lymphadenopathy | 30.28 | 12.57 | 173 | 135453 | 33326 | 50436172 |
Device dislocation | 30.22 | 12.57 | 10 | 135616 | 21536 | 50447962 |
Flatulence | 30.15 | 12.57 | 21 | 135605 | 29437 | 50440061 |
Cardiac cirrhosis | 30.04 | 12.57 | 12 | 135614 | 127 | 50469371 |
Blood bilirubin increased | 29.98 | 12.57 | 167 | 135459 | 31871 | 50437627 |
Hypotension | 29.75 | 12.57 | 834 | 134792 | 234635 | 50234863 |
Nightmare | 29.61 | 12.57 | 4 | 135622 | 16082 | 50453416 |
Electrocardiogram QT prolonged | 29.50 | 12.57 | 59 | 135567 | 51827 | 50417671 |
Kidney infection | 29.45 | 12.57 | 7 | 135619 | 18739 | 50450759 |
Pneumonitis chemical | 29.43 | 12.57 | 13 | 135613 | 180 | 50469318 |
Neuromuscular toxicity | 29.39 | 12.57 | 12 | 135614 | 135 | 50469363 |
Infusion related hypersensitivity reaction | 29.27 | 12.57 | 10 | 135616 | 65 | 50469433 |
Full blood count abnormal | 29.24 | 12.57 | 13 | 135613 | 23375 | 50446123 |
Eosinophilia | 29.24 | 12.57 | 7 | 135619 | 18645 | 50450853 |
Duodenitis haemorrhagic | 29.16 | 12.57 | 7 | 135619 | 8 | 50469490 |
Hyperhidrosis | 29.11 | 12.57 | 367 | 135259 | 89059 | 50380439 |
Immune-mediated hepatitis | 28.96 | 12.57 | 22 | 135604 | 882 | 50468616 |
Panic attack | 28.90 | 12.57 | 8 | 135618 | 19334 | 50450164 |
Vena cava thrombosis | 28.50 | 12.57 | 31 | 135595 | 1990 | 50467508 |
Pulmonary tumour thrombotic microangiopathy | 28.48 | 12.57 | 9 | 135617 | 44 | 50469454 |
Musculoskeletal disorder | 28.22 | 12.57 | 6 | 135620 | 17343 | 50452155 |
Pulse absent | 28.03 | 12.57 | 48 | 135578 | 4758 | 50464740 |
Neoplasm | 27.96 | 12.57 | 54 | 135572 | 5874 | 50463624 |
Venous thrombosis | 27.90 | 12.57 | 46 | 135580 | 4420 | 50465078 |
Cytopenia | 27.72 | 12.57 | 68 | 135558 | 8707 | 50460791 |
Aggression | 27.58 | 12.57 | 11 | 135615 | 21105 | 50448393 |
Acute lymphocytic leukaemia | 27.54 | 12.57 | 32 | 135594 | 2209 | 50467289 |
Neck pain | 27.48 | 12.57 | 71 | 135555 | 56996 | 50412502 |
Vocal cord paralysis | 27.39 | 12.57 | 28 | 135598 | 1673 | 50467825 |
Incorrect route of product administration | 27.37 | 12.57 | 8 | 135618 | 18658 | 50450840 |
Device malfunction | 27.27 | 12.57 | 4 | 135622 | 15117 | 50454381 |
Metastases to eye | 27.16 | 12.57 | 11 | 135615 | 121 | 50469377 |
Metastases to bladder | 27.11 | 12.57 | 12 | 135614 | 167 | 50469331 |
Ill-defined disorder | 27.10 | 12.57 | 67 | 135559 | 54587 | 50414911 |
Pruritus | 27.03 | 12.57 | 567 | 135059 | 283001 | 50186497 |
Joint range of motion decreased | 27.02 | 12.57 | 8 | 135618 | 18504 | 50450994 |
Dermatitis acneiform | 27.00 | 12.57 | 43 | 135583 | 4014 | 50465484 |
Tumour pain | 26.94 | 12.57 | 24 | 135602 | 1206 | 50468292 |
Therapeutic response unexpected | 26.94 | 12.57 | 5 | 135621 | 15910 | 50453588 |
Oropharyngeal pain | 26.94 | 12.57 | 112 | 135514 | 77689 | 50391809 |
Hypopituitarism | 26.92 | 12.57 | 21 | 135605 | 876 | 50468622 |
Sinus disorder | 26.90 | 12.57 | 8 | 135618 | 18450 | 50451048 |
Nasal septum perforation | 26.89 | 12.57 | 19 | 135607 | 680 | 50468818 |
Gastrointestinal necrosis | 26.88 | 12.57 | 34 | 135592 | 2564 | 50466934 |
Upper limb fracture | 26.84 | 12.57 | 5 | 135621 | 15868 | 50453630 |
Foot deformity | 26.80 | 12.57 | 9 | 135617 | 19201 | 50450297 |
Porokeratosis | 26.61 | 12.57 | 11 | 135615 | 128 | 50469370 |
Inflammation | 26.50 | 12.57 | 72 | 135554 | 56840 | 50412658 |
Glaucoma | 26.40 | 12.57 | 5 | 135621 | 15681 | 50453817 |
Pancreatitis | 26.39 | 12.57 | 46 | 135580 | 42568 | 50426930 |
Duodenal perforation | 26.36 | 12.57 | 19 | 135607 | 702 | 50468796 |
Wound dehiscence | 26.25 | 12.57 | 44 | 135582 | 4286 | 50465212 |
Rectal perforation | 26.18 | 12.57 | 15 | 135611 | 370 | 50469128 |
Blood pressure systolic increased | 26.08 | 12.57 | 34 | 135592 | 35415 | 50434083 |
Eastern Cooperative Oncology Group performance status worsened | 26.08 | 12.57 | 18 | 135608 | 620 | 50468878 |
Prescribed overdose | 26.01 | 12.57 | 4 | 135622 | 14596 | 50454902 |
Alanine aminotransferase increased | 25.99 | 12.57 | 356 | 135270 | 88003 | 50381495 |
Skin laceration | 25.98 | 12.57 | 9 | 135617 | 18833 | 50450665 |
Night sweats | 25.96 | 12.57 | 31 | 135595 | 33543 | 50435955 |
Thyroid dermatopathy | 25.89 | 12.57 | 7 | 135619 | 17 | 50469481 |
Fear | 25.89 | 12.57 | 4 | 135622 | 14545 | 50454953 |
Cytomegalovirus infection | 25.79 | 12.57 | 8 | 135618 | 17954 | 50451544 |
Pelvic abscess | 25.60 | 12.57 | 25 | 135601 | 1413 | 50468085 |
Accidental exposure to product | 25.57 | 12.57 | 15 | 135611 | 23042 | 50446456 |
Product quality issue | 25.49 | 12.57 | 27 | 135599 | 30831 | 50438667 |
Gastrointestinal fistula | 25.44 | 12.57 | 15 | 135611 | 391 | 50469107 |
Double hit lymphoma | 25.41 | 12.57 | 6 | 135620 | 6 | 50469492 |
Viral infection | 25.04 | 12.57 | 26 | 135600 | 29960 | 50439538 |
Mood swings | 24.98 | 12.57 | 6 | 135620 | 15948 | 50453550 |
Intestinal metastasis | 24.77 | 12.57 | 10 | 135616 | 109 | 50469389 |
Mastitis | 24.74 | 12.57 | 31 | 135595 | 2316 | 50467182 |
Xerophthalmia | 24.41 | 12.57 | 14 | 135612 | 346 | 50469152 |
Organising pneumonia | 24.39 | 12.57 | 45 | 135581 | 4729 | 50464769 |
Nail dystrophy | 24.37 | 12.57 | 19 | 135607 | 792 | 50468706 |
Jugular vein thrombosis | 24.35 | 12.57 | 33 | 135593 | 2663 | 50466835 |
Haemoglobin | 24.30 | 12.57 | 11 | 135615 | 162 | 50469336 |
Gastroenteritis radiation | 24.27 | 12.57 | 15 | 135611 | 427 | 50469071 |
Transfusion | 24.26 | 12.57 | 3 | 135623 | 12902 | 50456596 |
Hepatotoxicity | 24.21 | 12.57 | 140 | 135486 | 27086 | 50442412 |
Osteolysis | 24.17 | 12.57 | 32 | 135594 | 2525 | 50466973 |
Blood potassium increased | 24.09 | 12.57 | 7 | 135619 | 16391 | 50453107 |
Tooth erosion | 23.99 | 12.57 | 15 | 135611 | 436 | 50469062 |
Disability | 23.94 | 12.57 | 3 | 135623 | 12772 | 50456726 |
Lymphopenia | 23.91 | 12.57 | 94 | 135532 | 15527 | 50453971 |
Cancer pain | 23.88 | 12.57 | 32 | 135594 | 2555 | 50466943 |
Foot fracture | 23.84 | 12.57 | 12 | 135614 | 20079 | 50449419 |
Febrile infection | 23.77 | 12.57 | 22 | 135604 | 1162 | 50468336 |
Impaired work ability | 23.71 | 12.57 | 4 | 135622 | 13636 | 50455862 |
Bursitis | 23.71 | 12.57 | 15 | 135611 | 22120 | 50447378 |
Embryonal rhabdomyosarcoma | 23.69 | 12.57 | 6 | 135620 | 10 | 50469488 |
Drug level increased | 23.64 | 12.57 | 11 | 135615 | 19257 | 50450241 |
Emphysematous cystitis | 23.63 | 12.57 | 10 | 135616 | 124 | 50469374 |
Therapy cessation | 23.52 | 12.57 | 21 | 135605 | 25990 | 50443508 |
Spinal stenosis | 23.50 | 12.57 | 4 | 135622 | 13546 | 50455952 |
Cancer fatigue | 23.48 | 12.57 | 7 | 135619 | 27 | 50469471 |
Bone marrow infiltration | 23.48 | 12.57 | 15 | 135611 | 453 | 50469045 |
Carpal tunnel syndrome | 23.41 | 12.57 | 8 | 135618 | 16885 | 50452613 |
Intracranial tumour haemorrhage | 23.41 | 12.57 | 10 | 135616 | 127 | 50469371 |
Upper respiratory tract infection | 23.36 | 12.57 | 94 | 135532 | 65804 | 50403694 |
Guillain-Barre syndrome | 23.34 | 12.57 | 37 | 135589 | 3440 | 50466058 |
Congestive cardiomyopathy | 23.31 | 12.57 | 48 | 135578 | 5470 | 50464028 |
Pulmonary toxicity | 23.04 | 12.57 | 48 | 135578 | 5514 | 50463984 |
Right ventricular failure | 22.96 | 12.57 | 7 | 135619 | 15886 | 50453612 |
Vaginal fistula | 22.89 | 12.57 | 14 | 135612 | 391 | 50469107 |
Joint dislocation | 22.86 | 12.57 | 3 | 135623 | 12330 | 50457168 |
Full blood count decreased | 22.78 | 12.57 | 16 | 135610 | 22330 | 50447168 |
Cough | 22.73 | 12.57 | 825 | 134801 | 240439 | 50229059 |
Laryngeal necrosis | 22.67 | 12.57 | 6 | 135620 | 13 | 50469485 |
Acute pulmonary oedema | 22.63 | 12.57 | 56 | 135570 | 7211 | 50462287 |
Transient ischaemic attack | 22.58 | 12.57 | 32 | 135594 | 32178 | 50437320 |
Ankle fracture | 22.58 | 12.57 | 7 | 135619 | 15715 | 50453783 |
Eye disorder | 22.52 | 12.57 | 11 | 135615 | 18728 | 50450770 |
Scintillating scotoma | 22.48 | 12.57 | 10 | 135616 | 141 | 50469357 |
Vesical fistula | 22.44 | 12.57 | 8 | 135618 | 60 | 50469438 |
Peritoneal fibrosis | 22.28 | 12.57 | 5 | 135621 | 3 | 50469495 |
Computerised tomogram thorax | 22.23 | 12.57 | 10 | 135616 | 145 | 50469353 |
Metastases to ovary | 22.12 | 12.57 | 13 | 135613 | 337 | 50469161 |
Protein urine | 22.09 | 12.57 | 16 | 135610 | 596 | 50468902 |
Procedural pain | 22.06 | 12.57 | 5 | 135621 | 13827 | 50455671 |
Impaired healing | 22.02 | 12.57 | 104 | 135522 | 69682 | 50399816 |
Lymphatic disorder | 21.94 | 12.57 | 13 | 135613 | 342 | 50469156 |
Enterocolitis | 21.94 | 12.57 | 52 | 135574 | 6515 | 50462983 |
Haemolytic uraemic syndrome | 21.89 | 12.57 | 29 | 135597 | 2290 | 50467208 |
Dystonia | 21.87 | 12.57 | 3 | 135623 | 11923 | 50457575 |
Hypermetabolism | 21.86 | 12.57 | 10 | 135616 | 151 | 50469347 |
Scleroderma | 21.75 | 12.57 | 43 | 135583 | 4758 | 50464740 |
Vessel puncture site bruise | 21.74 | 12.57 | 13 | 135613 | 348 | 50469150 |
Stress cardiomyopathy | 21.69 | 12.57 | 58 | 135568 | 7829 | 50461669 |
Hypersomnia | 21.67 | 12.57 | 7 | 135619 | 15307 | 50454191 |
Abnormal behaviour | 21.50 | 12.57 | 13 | 135613 | 19645 | 50449853 |
Loss of consciousness | 21.45 | 12.57 | 396 | 135230 | 103957 | 50365541 |
Portal vein thrombosis | 21.40 | 12.57 | 28 | 135598 | 2184 | 50467314 |
Prescribed underdose | 21.34 | 12.57 | 8 | 135618 | 15941 | 50453557 |
Accidental overdose | 21.25 | 12.57 | 13 | 135613 | 19520 | 50449978 |
Gelastic seizure | 21.17 | 12.57 | 5 | 135621 | 5 | 50469493 |
Blood iron decreased | 21.11 | 12.57 | 3 | 135623 | 11612 | 50457886 |
Tumour associated fever | 21.07 | 12.57 | 10 | 135616 | 165 | 50469333 |
Blast cells present | 21 | 12.57 | 13 | 135613 | 371 | 50469127 |
Ovarian cancer metastatic | 20.99 | 12.57 | 17 | 135609 | 749 | 50468749 |
Brachiocephalic vein thrombosis | 20.98 | 12.57 | 8 | 135618 | 74 | 50469424 |
Pelvic pain | 20.97 | 12.57 | 72 | 135554 | 11141 | 50458357 |
Abdominal infection | 20.88 | 12.57 | 24 | 135602 | 1638 | 50467860 |
Ovarian cancer | 20.82 | 12.57 | 44 | 135582 | 5105 | 50464393 |
Wrist fracture | 20.80 | 12.57 | 3 | 135623 | 11484 | 50458014 |
Retroperitoneal lymphadenopathy | 20.76 | 12.57 | 14 | 135612 | 464 | 50469034 |
Pulmonary vein stenosis | 20.61 | 12.57 | 8 | 135618 | 78 | 50469420 |
Hepatic vein thrombosis | 20.55 | 12.57 | 9 | 135617 | 122 | 50469376 |
Seroma | 20.50 | 12.57 | 25 | 135601 | 1816 | 50467682 |
Sinus congestion | 20.46 | 12.57 | 6 | 135620 | 13965 | 50455533 |
BRAF gene mutation | 20.17 | 12.57 | 7 | 135619 | 48 | 50469450 |
Femur fracture | 20.12 | 12.57 | 44 | 135582 | 37420 | 50432078 |
Balance disorder | 20.11 | 12.57 | 109 | 135517 | 70481 | 50399017 |
Transaminases | 20.08 | 12.57 | 8 | 135618 | 84 | 50469414 |
Vulvovaginal inflammation | 20.06 | 12.57 | 15 | 135611 | 587 | 50468911 |
Septic shock | 20.05 | 12.57 | 238 | 135388 | 56937 | 50412561 |
Underdose | 20.04 | 12.57 | 15 | 135611 | 20263 | 50449235 |
Enterocutaneous fistula | 19.99 | 12.57 | 20 | 135606 | 1164 | 50468334 |
Lymphangitis | 19.98 | 12.57 | 17 | 135609 | 803 | 50468695 |
Cerebral ischaemia | 19.97 | 12.57 | 47 | 135579 | 5861 | 50463637 |
Splenic artery thrombosis | 19.93 | 12.57 | 7 | 135619 | 50 | 50469448 |
Bladder perforation | 19.85 | 12.57 | 9 | 135617 | 133 | 50469365 |
Cholangitis infective | 19.85 | 12.57 | 10 | 135616 | 189 | 50469309 |
Fungal infection | 19.81 | 12.57 | 31 | 135595 | 29934 | 50439564 |
Emotional distress | 19.58 | 12.57 | 29 | 135597 | 28634 | 50440864 |
Hydrothorax | 19.56 | 12.57 | 16 | 135610 | 715 | 50468783 |
Hallucination, visual | 19.53 | 12.57 | 10 | 135616 | 16572 | 50452926 |
Device issue | 19.45 | 12.57 | 15 | 135611 | 19957 | 50449541 |
Weight decreased | 19.45 | 12.57 | 448 | 135178 | 220797 | 50248701 |
Emotional disorder | 19.44 | 12.57 | 4 | 135622 | 11832 | 50457666 |
Tumour ulceration | 19.38 | 12.57 | 9 | 135617 | 141 | 50469357 |
Sopor | 19.27 | 12.57 | 15 | 135611 | 19864 | 50449634 |
Duodenal obstruction | 19.20 | 12.57 | 10 | 135616 | 203 | 50469295 |
Laryngeal cancer stage III | 19.16 | 12.57 | 5 | 135621 | 10 | 50469488 |
Venous thrombosis limb | 19.14 | 12.57 | 29 | 135597 | 2593 | 50466905 |
Neutrophil count abnormal | 19.10 | 12.57 | 28 | 135598 | 2431 | 50467067 |
Bone erosion | 19.09 | 12.57 | 4 | 135622 | 11683 | 50457815 |
Eye pruritus | 19.07 | 12.57 | 5 | 135621 | 12529 | 50456969 |
Respiratory depth decreased | 19.04 | 12.57 | 6 | 135620 | 29 | 50469469 |
Ear pain | 18.95 | 12.57 | 29 | 135597 | 28254 | 50441244 |
Keratitis | 18.87 | 12.57 | 28 | 135598 | 2457 | 50467041 |
Breast ulceration | 18.82 | 12.57 | 7 | 135619 | 60 | 50469438 |
Malignant peritoneal neoplasm | 18.82 | 12.57 | 15 | 135611 | 646 | 50468852 |
Ocular hyperaemia | 18.81 | 12.57 | 16 | 135610 | 20276 | 50449222 |
Enteritis | 18.79 | 12.57 | 51 | 135575 | 6944 | 50462554 |
Tumour invasion | 18.77 | 12.57 | 8 | 135618 | 101 | 50469397 |
Pelvic infection | 18.75 | 12.57 | 11 | 135615 | 284 | 50469214 |
Metastases to thorax | 18.73 | 12.57 | 10 | 135616 | 214 | 50469284 |
Thrombophlebitis migrans | 18.70 | 12.57 | 8 | 135618 | 102 | 50469396 |
Colitis ulcerative | 18.64 | 12.57 | 11 | 135615 | 16843 | 50452655 |
Muscle twitching | 18.64 | 12.57 | 9 | 135617 | 15422 | 50454076 |
Diverticulitis | 18.63 | 12.57 | 38 | 135588 | 33144 | 50436354 |
Blood glucose decreased | 18.61 | 12.57 | 13 | 135613 | 18198 | 50451300 |
Gout | 18.59 | 12.57 | 4 | 135622 | 11466 | 50458032 |
Nail ridging | 18.51 | 12.57 | 11 | 135615 | 291 | 50469207 |
Gastroenteritis viral | 18.43 | 12.57 | 14 | 135612 | 18772 | 50450726 |
Abdominal lymphadenopathy | 18.42 | 12.57 | 15 | 135611 | 666 | 50468832 |
Post procedural fistula | 18.40 | 12.57 | 10 | 135616 | 222 | 50469276 |
Joint effusion | 18.34 | 12.57 | 6 | 135620 | 13015 | 50456483 |
Dementia | 18.32 | 12.57 | 10 | 135616 | 15987 | 50453511 |
Breast neoplasm | 18.27 | 12.57 | 20 | 135606 | 1293 | 50468205 |
Poor quality sleep | 18.22 | 12.57 | 11 | 135615 | 16635 | 50452863 |
Metastases to adrenals | 18.17 | 12.57 | 15 | 135611 | 679 | 50468819 |
Myoclonus | 18.16 | 12.57 | 8 | 135618 | 14462 | 50455036 |
Metastases to pancreas | 18.12 | 12.57 | 10 | 135616 | 229 | 50469269 |
Aorto-oesophageal fistula | 17.99 | 12.57 | 5 | 135621 | 14 | 50469484 |
Product supply issue | 17.98 | 12.57 | 19 | 135607 | 1180 | 50468318 |
Chest pain | 17.93 | 12.57 | 610 | 135016 | 176272 | 50293226 |
Influenza like illness | 17.91 | 12.57 | 86 | 135540 | 57373 | 50412125 |
Intestinal ischaemia | 17.89 | 12.57 | 49 | 135577 | 6708 | 50462790 |
Neutropenic infection | 17.69 | 12.57 | 18 | 135608 | 1069 | 50468429 |
Onychomadesis | 17.65 | 12.57 | 33 | 135593 | 3503 | 50465995 |
Respiratory tract congestion | 17.58 | 12.57 | 8 | 135618 | 14191 | 50455307 |
Angiodermatitis | 17.53 | 12.57 | 7 | 135619 | 74 | 50469424 |
Vaginal perforation | 17.49 | 12.57 | 5 | 135621 | 16 | 50469482 |
Intestinal prolapse | 17.48 | 12.57 | 8 | 135618 | 121 | 50469377 |
Liver scan abnormal | 17.43 | 12.57 | 6 | 135620 | 40 | 50469458 |
Rash papular | 17.41 | 12.57 | 6 | 135620 | 12598 | 50456900 |
Ovarian failure | 17.37 | 12.57 | 18 | 135608 | 1093 | 50468405 |
Dermatomyositis | 17.35 | 12.57 | 25 | 135601 | 2136 | 50467362 |
Eye swelling | 17.35 | 12.57 | 17 | 135609 | 20127 | 50449371 |
Sciatica | 17.34 | 12.57 | 19 | 135607 | 21363 | 50448135 |
Blood creatinine decreased | 17.28 | 12.57 | 40 | 135586 | 4936 | 50464562 |
Tumour fistulisation | 17.26 | 12.57 | 5 | 135621 | 17 | 50469481 |
Pneumonia | 17.16 | 12.57 | 834 | 134792 | 377567 | 50091931 |
Drug ineffective for unapproved indication | 17.16 | 12.57 | 19 | 135607 | 21262 | 50448236 |
Sensory disturbance | 17.16 | 12.57 | 70 | 135556 | 11759 | 50457739 |
Breast cellulitis | 17.14 | 12.57 | 13 | 135613 | 520 | 50468978 |
Embolism venous | 17.13 | 12.57 | 27 | 135599 | 2498 | 50467000 |
Exostosis | 17.07 | 12.57 | 5 | 135621 | 11648 | 50457850 |
Gene mutation | 17.06 | 12.57 | 19 | 135607 | 1252 | 50468246 |
Seasonal allergy | 17.06 | 12.57 | 9 | 135617 | 14667 | 50454831 |
Adrenocorticotropic hormone deficiency | 17.05 | 12.57 | 10 | 135616 | 258 | 50469240 |
Cardiac murmur | 16.99 | 12.57 | 4 | 135622 | 10780 | 50458718 |
Anaemia of malignant disease | 16.97 | 12.57 | 12 | 135614 | 430 | 50469068 |
Cholelithiasis | 16.97 | 12.57 | 49 | 135577 | 37924 | 50431574 |
Mediastinitis | 16.97 | 12.57 | 9 | 135617 | 190 | 50469308 |
Maternal death affecting foetus | 16.94 | 12.57 | 4 | 135622 | 4 | 50469494 |
Aortic dissection rupture | 16.94 | 12.57 | 4 | 135622 | 4 | 50469494 |
Radiation oesophagitis | 16.92 | 12.57 | 10 | 135616 | 262 | 50469236 |
Lymphatic obstruction | 16.83 | 12.57 | 5 | 135621 | 19 | 50469479 |
Invasive ductal breast carcinoma | 16.74 | 12.57 | 44 | 135582 | 5877 | 50463621 |
Cardiac failure congestive | 16.73 | 12.57 | 145 | 135481 | 84237 | 50385261 |
Acute erythroid leukaemia | 16.71 | 12.57 | 6 | 135620 | 46 | 50469452 |
Bacterial diarrhoea | 16.71 | 12.57 | 6 | 135620 | 46 | 50469452 |
Seizure | 16.71 | 12.57 | 219 | 135407 | 117655 | 50351843 |
Respiratory failure | 16.69 | 12.57 | 340 | 135286 | 90841 | 50378657 |
Metastases to muscle | 16.69 | 12.57 | 8 | 135618 | 135 | 50469363 |
Mediastinal disorder | 16.65 | 12.57 | 11 | 135615 | 352 | 50469146 |
Nail avulsion | 16.64 | 12.57 | 8 | 135618 | 136 | 50469362 |
Distal intestinal obstruction syndrome | 16.60 | 12.57 | 11 | 135615 | 354 | 50469144 |
Angioedema | 16.56 | 12.57 | 49 | 135577 | 37627 | 50431871 |
Infected lymphocele | 16.55 | 12.57 | 9 | 135617 | 200 | 50469298 |
Delirium | 16.55 | 12.57 | 50 | 135576 | 38142 | 50431356 |
Eye irritation | 16.53 | 12.57 | 13 | 135613 | 17127 | 50452371 |
Subdural haematoma | 16.50 | 12.57 | 7 | 135619 | 12940 | 50456558 |
Gastric perforation | 16.43 | 12.57 | 20 | 135606 | 1450 | 50468048 |
Myeloproliferative neoplasm | 16.40 | 12.57 | 12 | 135614 | 454 | 50469044 |
Infection | 16.40 | 12.57 | 346 | 135280 | 172608 | 50296890 |
Exposed bone in jaw | 16.37 | 12.57 | 28 | 135598 | 2772 | 50466726 |
Gingival bleeding | 16.32 | 12.57 | 67 | 135559 | 11286 | 50458212 |
Median nerve injury | 16.25 | 12.57 | 5 | 135621 | 22 | 50469476 |
Toxic neuropathy | 16.14 | 12.57 | 11 | 135615 | 371 | 50469127 |
Mood altered | 16.13 | 12.57 | 7 | 135619 | 12766 | 50456732 |
Nasal disorder | 16.10 | 12.57 | 25 | 135601 | 2283 | 50467215 |
Cystitis noninfective | 16.10 | 12.57 | 15 | 135611 | 799 | 50468699 |
Bronchopleural fistula | 16.08 | 12.57 | 9 | 135617 | 212 | 50469286 |
Photophobia | 16.06 | 12.57 | 10 | 135616 | 14877 | 50454621 |
Nail infection | 16.03 | 12.57 | 23 | 135603 | 1958 | 50467540 |
Ileal perforation | 15.96 | 12.57 | 11 | 135615 | 378 | 50469120 |
Thyroid disorder | 15.92 | 12.57 | 7 | 135619 | 12670 | 50456828 |
Aplasia | 15.91 | 12.57 | 33 | 135593 | 3780 | 50465718 |
Immediate post-injection reaction | 15.89 | 12.57 | 11 | 135615 | 381 | 50469117 |
Liver function test abnormal | 15.87 | 12.57 | 63 | 135563 | 44276 | 50425222 |
Acquired gene mutation | 15.84 | 12.57 | 15 | 135611 | 816 | 50468682 |
Mechanical ileus | 15.83 | 12.57 | 10 | 135616 | 296 | 50469202 |
Lividity | 15.82 | 12.57 | 9 | 135617 | 219 | 50469279 |
Blood alkaline phosphatase increased | 15.81 | 12.57 | 162 | 135464 | 37364 | 50432134 |
Rash | 15.81 | 12.57 | 986 | 134640 | 436485 | 50033013 |
HER2 positive breast cancer | 15.68 | 12.57 | 10 | 135616 | 301 | 50469197 |
Vaginal cuff dehiscence | 15.67 | 12.57 | 4 | 135622 | 7 | 50469491 |
Cholecystectomy | 15.58 | 12.57 | 3 | 135623 | 9300 | 50460198 |
Blood pressure immeasurable | 15.58 | 12.57 | 17 | 135609 | 1095 | 50468403 |
Carbohydrate antigen 19-9 increased | 15.52 | 12.57 | 8 | 135618 | 159 | 50469339 |
Pulmonary artery stenosis | 15.52 | 12.57 | 8 | 135618 | 159 | 50469339 |
Pulmonary congestion | 15.43 | 12.57 | 11 | 135615 | 15236 | 50454262 |
Artificial menopause | 15.41 | 12.57 | 5 | 135621 | 27 | 50469471 |
Orbital myositis | 15.41 | 12.57 | 5 | 135621 | 27 | 50469471 |
Restless legs syndrome | 15.40 | 12.57 | 12 | 135614 | 15885 | 50453613 |
Tongue disorder | 15.38 | 12.57 | 3 | 135623 | 9213 | 50460285 |
Blood magnesium decreased | 15.37 | 12.57 | 65 | 135561 | 11095 | 50458403 |
Limb discomfort | 15.35 | 12.57 | 26 | 135600 | 24331 | 50445167 |
Application site recall reaction | 15.33 | 12.57 | 4 | 135622 | 8 | 50469490 |
Arterioenteric fistula | 15.33 | 12.57 | 4 | 135622 | 8 | 50469490 |
Mucosal dryness | 15.24 | 12.57 | 25 | 135601 | 2392 | 50467106 |
Productive cough | 15.21 | 12.57 | 81 | 135545 | 52613 | 50416885 |
Myeloid leukaemia | 15.19 | 12.57 | 10 | 135616 | 318 | 50469180 |
Pancreatic failure | 15.14 | 12.57 | 15 | 135611 | 863 | 50468635 |
Carcinoid tumour pulmonary | 15.13 | 12.57 | 11 | 135615 | 412 | 50469086 |
Electrolyte imbalance | 15.08 | 12.57 | 88 | 135538 | 17081 | 50452417 |
BRCA2 gene mutation | 15.06 | 12.57 | 6 | 135620 | 63 | 50469435 |
Product storage error | 14.96 | 12.57 | 7 | 135619 | 12217 | 50457281 |
Cholangitis acute | 14.95 | 12.57 | 11 | 135615 | 420 | 50469078 |
Pain in jaw | 14.79 | 12.57 | 53 | 135573 | 38375 | 50431123 |
Myiasis | 14.77 | 12.57 | 3 | 135623 | 0 | 50469498 |
Granulocyte count | 14.77 | 12.57 | 3 | 135623 | 0 | 50469498 |
Ankyloglossia acquired | 14.77 | 12.57 | 3 | 135623 | 0 | 50469498 |
Immune-mediated renal disorder | 14.77 | 12.57 | 3 | 135623 | 0 | 50469498 |
Glycosylated haemoglobin increased | 14.74 | 12.57 | 5 | 135621 | 10601 | 50458897 |
Acute monocytic leukaemia | 14.74 | 12.57 | 6 | 135620 | 67 | 50469431 |
Clonal haematopoiesis | 14.71 | 12.57 | 4 | 135622 | 10 | 50469488 |
Hepatic cancer metastatic | 14.68 | 12.57 | 10 | 135616 | 337 | 50469161 |
Anger | 14.65 | 12.57 | 6 | 135620 | 11327 | 50458171 |
Nail pigmentation | 14.62 | 12.57 | 8 | 135618 | 180 | 50469318 |
Faeces discoloured | 14.60 | 12.57 | 13 | 135613 | 16111 | 50453387 |
Thyroiditis | 14.52 | 12.57 | 21 | 135605 | 1801 | 50467697 |
Localised infection | 14.47 | 12.57 | 29 | 135597 | 25456 | 50444042 |
Sputum discoloured | 14.45 | 12.57 | 9 | 135617 | 13386 | 50456112 |
Obstructive shock | 14.44 | 12.57 | 5 | 135621 | 34 | 50469464 |
Cholecystitis chronic | 14.44 | 12.57 | 4 | 135622 | 9665 | 50459833 |
Endometrial cancer recurrent | 14.44 | 12.57 | 4 | 135622 | 11 | 50469487 |
Opsoclonus myoclonus | 14.40 | 12.57 | 7 | 135619 | 122 | 50469376 |
Speech disorder | 14.37 | 12.57 | 48 | 135578 | 35500 | 50433998 |
Depressed level of consciousness | 14.37 | 12.57 | 81 | 135545 | 51872 | 50417626 |
Oesophageal squamous cell carcinoma | 14.35 | 12.57 | 7 | 135619 | 123 | 50469375 |
Postoperative adhesion | 14.32 | 12.57 | 9 | 135617 | 264 | 50469234 |
Taste disorder | 14.32 | 12.57 | 52 | 135574 | 8272 | 50461226 |
Meibomian gland dysfunction | 14.30 | 12.57 | 7 | 135619 | 124 | 50469374 |
Ovarian cyst | 14.29 | 12.57 | 10 | 135616 | 13986 | 50455512 |
Complication associated with device | 14.28 | 12.57 | 11 | 135615 | 14644 | 50454854 |
Clonal evolution | 14.28 | 12.57 | 6 | 135620 | 73 | 50469425 |
Hypothalamo-pituitary disorder | 14.25 | 12.57 | 13 | 135613 | 674 | 50468824 |
Cystitis haemorrhagic | 14.24 | 12.57 | 31 | 135595 | 3671 | 50465827 |
Thinking abnormal | 14.21 | 12.57 | 4 | 135622 | 9563 | 50459935 |
Transaminases abnormal | 14.15 | 12.57 | 12 | 135614 | 564 | 50468934 |
Polymicrogyria | 14.13 | 12.57 | 6 | 135620 | 75 | 50469423 |
Hiatus hernia | 14.11 | 12.57 | 17 | 135609 | 18327 | 50451171 |
Anhedonia | 14.11 | 12.57 | 4 | 135622 | 9520 | 50459978 |
Scar | 14.11 | 12.57 | 7 | 135619 | 11811 | 50457687 |
Ureteric stenosis | 14.10 | 12.57 | 12 | 135614 | 567 | 50468931 |
Glomerular vascular disorder | 14.08 | 12.57 | 5 | 135621 | 37 | 50469461 |
Hyperferritinaemia | 14.05 | 12.57 | 7 | 135619 | 129 | 50469369 |
Toxic cardiomyopathy | 14.05 | 12.57 | 7 | 135619 | 129 | 50469369 |
Lung infiltration | 14.02 | 12.57 | 72 | 135554 | 13321 | 50456177 |
Extrapyramidal disorder | 14.01 | 12.57 | 7 | 135619 | 11763 | 50457735 |
Live birth | 13.95 | 12.57 | 14 | 135612 | 16394 | 50453104 |
Pulpitis dental | 13.94 | 12.57 | 14 | 135612 | 819 | 50468679 |
Macular degeneration | 13.77 | 12.57 | 11 | 135615 | 14377 | 50455121 |
Immune-mediated lung disease | 13.70 | 12.57 | 10 | 135616 | 377 | 50469121 |
Ototoxicity | 13.70 | 12.57 | 16 | 135610 | 1111 | 50468387 |
Hereditary motor and sensory neuropathy | 13.59 | 12.57 | 6 | 135620 | 83 | 50469415 |
Tuberculosis | 13.59 | 12.57 | 5 | 135621 | 10078 | 50459420 |
Morphoea | 13.57 | 12.57 | 9 | 135617 | 290 | 50469208 |
Aortic dissection | 13.55 | 12.57 | 19 | 135607 | 1584 | 50467914 |
Rotator cuff syndrome | 13.54 | 12.57 | 7 | 135619 | 11537 | 50457961 |
Immune-mediated myocarditis | 13.52 | 12.57 | 6 | 135620 | 84 | 50469414 |
Obesity | 13.50 | 12.57 | 15 | 135611 | 16760 | 50452738 |
Bone marrow disorder | 13.45 | 12.57 | 21 | 135605 | 1927 | 50467571 |
Catheter site thrombosis | 13.45 | 12.57 | 7 | 135619 | 142 | 50469356 |
Hyponatraemia | 13.40 | 12.57 | 345 | 135281 | 95794 | 50373704 |
Soft tissue necrosis | 13.34 | 12.57 | 10 | 135616 | 393 | 50469105 |
Corneal disorder | 13.34 | 12.57 | 19 | 135607 | 1607 | 50467891 |
Essential thrombocythaemia | 13.32 | 12.57 | 7 | 135619 | 145 | 50469353 |
Hypergeusia | 13.30 | 12.57 | 4 | 135622 | 16 | 50469482 |
Systolic dysfunction | 13.27 | 12.57 | 18 | 135608 | 1454 | 50468044 |
Uterine adhesions | 13.23 | 12.57 | 5 | 135621 | 45 | 50469453 |
Oesophageal varices haemorrhage | 13.15 | 12.57 | 15 | 135611 | 1015 | 50468483 |
Dermatitis | 13.14 | 12.57 | 74 | 135552 | 14177 | 50455321 |
Uterine atrophy | 13.13 | 12.57 | 5 | 135621 | 46 | 50469452 |
Metastases to vagina | 13.11 | 12.57 | 4 | 135622 | 17 | 50469481 |
Urinary retention | 13.06 | 12.57 | 32 | 135594 | 26158 | 50443340 |
Respiratory depression | 13.05 | 12.57 | 8 | 135618 | 12002 | 50457496 |
Peritoneal neoplasm | 13.04 | 12.57 | 5 | 135621 | 47 | 50469451 |
Renal failure | 13.04 | 12.57 | 204 | 135422 | 106429 | 50363069 |
Dandy-Walker syndrome | 13.04 | 12.57 | 6 | 135620 | 92 | 50469406 |
Metastases to abdominal cavity | 13.03 | 12.57 | 10 | 135616 | 407 | 50469091 |
Delusion | 13.02 | 12.57 | 6 | 135620 | 10563 | 50458935 |
Anal sphincter atony | 12.96 | 12.57 | 8 | 135618 | 227 | 50469271 |
Malignant neoplasm of pleura | 12.95 | 12.57 | 5 | 135621 | 48 | 50469450 |
Failure to thrive | 12.93 | 12.57 | 42 | 135584 | 6316 | 50463182 |
Affect lability | 12.93 | 12.57 | 4 | 135622 | 8994 | 50460504 |
Foetal malnutrition | 12.86 | 12.57 | 6 | 135620 | 95 | 50469403 |
Pneumothorax spontaneous | 12.81 | 12.57 | 12 | 135614 | 644 | 50468854 |
Biliary obstruction | 12.79 | 12.57 | 23 | 135603 | 2370 | 50467128 |
Urosepsis | 12.77 | 12.57 | 78 | 135548 | 15387 | 50454111 |
Peritoneal fluid analysis abnormal | 12.75 | 12.57 | 4 | 135622 | 19 | 50469479 |
Blood lactate dehydrogenase increased | 12.74 | 12.57 | 93 | 135533 | 19469 | 50450029 |
Chemotherapy | 12.74 | 12.57 | 17 | 135609 | 1352 | 50468146 |
Lichenoid keratosis | 12.71 | 12.57 | 17 | 135609 | 1355 | 50468143 |
Tumour cavitation | 12.70 | 12.57 | 3 | 135623 | 3 | 50469495 |
Breast sarcoma | 12.70 | 12.57 | 3 | 135623 | 3 | 50469495 |
Breast prosthesis removal | 12.70 | 12.57 | 3 | 135623 | 3 | 50469495 |
Torsade de pointes | 12.70 | 12.57 | 8 | 135618 | 11827 | 50457671 |
Haemolytic anaemia | 12.70 | 12.57 | 54 | 135572 | 9238 | 50460260 |
Product dispensing error | 12.69 | 12.57 | 4 | 135622 | 8887 | 50460611 |
Lymphorrhoea | 12.68 | 12.57 | 5 | 135621 | 51 | 50469447 |
Hyperlipidaemia | 12.64 | 12.57 | 17 | 135609 | 17473 | 50452025 |
Haemodynamic instability | 12.60 | 12.57 | 3 | 135623 | 8021 | 50461477 |
Activated PI3 kinase delta syndrome | 12.59 | 12.57 | 4 | 135622 | 20 | 50469478 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 586.38 | 15.76 | 779 | 43624 | 111461 | 29418663 |
Malignant neoplasm progression | 576.61 | 15.76 | 629 | 43774 | 73230 | 29456894 |
Neutropenia | 567.22 | 15.76 | 833 | 43570 | 130878 | 29399246 |
Interstitial lung disease | 350.00 | 15.76 | 432 | 43971 | 57286 | 29472838 |
Neuropathy peripheral | 308.78 | 15.76 | 452 | 43951 | 70575 | 29459549 |
Disease progression | 252.72 | 15.76 | 446 | 43957 | 81470 | 29448654 |
Leukopenia | 246.60 | 15.76 | 356 | 44047 | 54847 | 29475277 |
Pneumonitis | 239.70 | 15.76 | 251 | 44152 | 27793 | 29502331 |
Anaemia | 232.37 | 15.76 | 745 | 43658 | 200206 | 29329918 |
Thrombocytopenia | 230.36 | 15.76 | 576 | 43827 | 134247 | 29395877 |
Neutrophil count decreased | 219.91 | 15.76 | 298 | 44105 | 43269 | 29486855 |
Alopecia | 200.28 | 15.76 | 191 | 44212 | 18893 | 29511231 |
Death | 184.65 | 15.76 | 1003 | 43400 | 341081 | 29189043 |
Cholangitis | 174.80 | 15.76 | 120 | 44283 | 7417 | 29522707 |
Mucosal inflammation | 144.23 | 15.76 | 206 | 44197 | 31389 | 29498735 |
Cystoid macular oedema | 141.01 | 15.76 | 48 | 44355 | 588 | 29529536 |
Radiation pneumonitis | 128.25 | 15.76 | 64 | 44339 | 2165 | 29527959 |
Myelosuppression | 125.65 | 15.76 | 121 | 44282 | 12106 | 29518018 |
Bone marrow failure | 122.38 | 15.76 | 177 | 44226 | 27272 | 29502852 |
Completed suicide | 117.60 | 15.76 | 4 | 44399 | 90242 | 29439882 |
Product dose omission issue | 113.76 | 15.76 | 8 | 44395 | 96375 | 29433749 |
General physical health deterioration | 110.90 | 15.76 | 373 | 44030 | 102484 | 29427640 |
Metastases to central nervous system | 108.15 | 15.76 | 88 | 44315 | 7043 | 29523081 |
Flushing | 108.06 | 15.76 | 172 | 44231 | 28820 | 29501304 |
Haemoptysis | 106.73 | 15.76 | 176 | 44227 | 30374 | 29499750 |
Haematotoxicity | 106.54 | 15.76 | 85 | 44318 | 6614 | 29523510 |
Neoplasm progression | 97.92 | 15.76 | 130 | 44273 | 18482 | 29511642 |
Polyneuropathy | 97.09 | 15.76 | 105 | 44298 | 12047 | 29518077 |
Peripheral sensory neuropathy | 93.68 | 15.76 | 75 | 44328 | 5864 | 29524260 |
Overdose | 93.10 | 15.76 | 7 | 44396 | 79812 | 29450312 |
Drug ineffective | 91.41 | 15.76 | 263 | 44140 | 362907 | 29167217 |
Neurotoxicity | 90.99 | 15.76 | 111 | 44292 | 14502 | 29515622 |
Immune-mediated hepatitis | 88.31 | 15.76 | 44 | 44359 | 1483 | 29528641 |
Pyrexia | 88.24 | 15.76 | 734 | 43669 | 286888 | 29243236 |
Dehydration | 87.86 | 15.76 | 373 | 44030 | 114375 | 29415749 |
Radiation oesophagitis | 87.51 | 15.76 | 30 | 44373 | 376 | 29529748 |
Pneumothorax | 83.86 | 15.76 | 111 | 44292 | 15731 | 29514393 |
Erythema | 79.49 | 15.76 | 272 | 44131 | 75334 | 29454790 |
Decreased appetite | 77.68 | 15.76 | 426 | 43977 | 144916 | 29385208 |
Depression | 74.69 | 15.76 | 18 | 44385 | 85129 | 29444995 |
Fall | 74.57 | 15.76 | 94 | 44309 | 177084 | 29353040 |
Biliary tract infection | 74.53 | 15.76 | 28 | 44375 | 464 | 29529660 |
Sepsis | 68.86 | 15.76 | 407 | 43996 | 142275 | 29387849 |
Dyspnoea | 68.60 | 15.76 | 770 | 43633 | 325962 | 29204162 |
White blood cell count decreased | 66.10 | 15.76 | 274 | 44129 | 83088 | 29447036 |
Pneumonia | 63.80 | 15.76 | 747 | 43656 | 319425 | 29210699 |
Drug interaction | 63.78 | 15.76 | 125 | 44278 | 197260 | 29332864 |
Tumour haemorrhage | 63.43 | 15.76 | 42 | 44361 | 2443 | 29527681 |
Pancytopenia | 63.32 | 15.76 | 270 | 44133 | 82898 | 29447226 |
Liver abscess | 63.24 | 15.76 | 47 | 44356 | 3291 | 29526833 |
Immune-mediated lung disease | 62.48 | 15.76 | 28 | 44375 | 740 | 29529384 |
Anaphylactic shock | 62.36 | 15.76 | 88 | 44315 | 13248 | 29516876 |
Therapy partial responder | 62.18 | 15.76 | 56 | 44347 | 5143 | 29524981 |
Anxiety | 60.81 | 15.76 | 26 | 44377 | 85339 | 29444785 |
Thrombotic microangiopathy | 60.74 | 15.76 | 70 | 44333 | 8611 | 29521513 |
Pancreatic carcinoma metastatic | 59.97 | 15.76 | 42 | 44361 | 2679 | 29527445 |
Metastases to lung | 59.49 | 15.76 | 66 | 44337 | 7789 | 29522335 |
Headache | 59.01 | 15.76 | 107 | 44296 | 173900 | 29356224 |
Pancreatic carcinoma | 57.49 | 15.76 | 62 | 44341 | 7088 | 29523036 |
Gastrointestinal perforation | 57.10 | 15.76 | 45 | 44358 | 3438 | 29526686 |
Kounis syndrome | 56.84 | 15.76 | 35 | 44368 | 1794 | 29528330 |
Colitis | 56.82 | 15.76 | 137 | 44266 | 31111 | 29499013 |
Onycholysis | 56.65 | 15.76 | 23 | 44380 | 473 | 29529651 |
Nausea | 54.10 | 15.76 | 667 | 43736 | 288588 | 29241536 |
Nasopharyngitis | 53.53 | 15.76 | 12 | 44391 | 59653 | 29470471 |
Toxicity to various agents | 51.02 | 15.76 | 116 | 44287 | 173545 | 29356579 |
Joint swelling | 51.01 | 15.76 | 7 | 44396 | 49623 | 29480501 |
Hypersensitivity | 50.97 | 15.76 | 185 | 44218 | 52718 | 29477406 |
Infusion related reaction | 50.64 | 15.76 | 163 | 44240 | 43723 | 29486401 |
Platelet count decreased | 49.42 | 15.76 | 297 | 44106 | 104375 | 29425749 |
Metastases to liver | 49.27 | 15.76 | 74 | 44329 | 11782 | 29518342 |
Insomnia | 48.96 | 15.76 | 37 | 44366 | 88724 | 29441400 |
Somnolence | 48.29 | 15.76 | 42 | 44361 | 93913 | 29436211 |
Vomiting | 47.96 | 15.76 | 508 | 43895 | 211752 | 29318372 |
Metastases to meninges | 47.80 | 15.76 | 27 | 44376 | 1178 | 29528946 |
Hospitalisation | 46.07 | 15.76 | 7 | 44396 | 45981 | 29484143 |
Diarrhoea | 45.56 | 15.76 | 726 | 43677 | 331972 | 29198152 |
Plasma cell myeloma | 43.99 | 15.76 | 3 | 44400 | 37112 | 29493012 |
Coronary artery disease | 43.64 | 15.76 | 7 | 44396 | 44183 | 29485941 |
Weight increased | 43.52 | 15.76 | 31 | 44372 | 76636 | 29453488 |
Cardiac failure congestive | 42.13 | 15.76 | 32 | 44371 | 76549 | 29453575 |
Pleural effusion | 41.20 | 15.76 | 215 | 44188 | 71693 | 29458431 |
Pulmonary radiation injury | 40.91 | 15.76 | 11 | 44392 | 55 | 29530069 |
Suicidal ideation | 40.59 | 15.76 | 3 | 44400 | 34713 | 29495411 |
Electrocardiogram QT prolonged | 39.86 | 15.76 | 4 | 44399 | 36133 | 29493991 |
Tracheo-oesophageal fistula | 39.25 | 15.76 | 17 | 44386 | 413 | 29529711 |
Scleroderma-like reaction | 39.20 | 15.76 | 10 | 44393 | 39 | 29530085 |
Aggression | 39.03 | 15.76 | 4 | 44399 | 35537 | 29494587 |
Tremor | 38.85 | 15.76 | 32 | 44371 | 73506 | 29456618 |
Tracheal fistula | 38.41 | 15.76 | 11 | 44392 | 72 | 29530052 |
Bronchial fistula | 38.35 | 15.76 | 13 | 44390 | 157 | 29529967 |
Intentional product misuse | 37.80 | 15.76 | 4 | 44399 | 34657 | 29495467 |
Embolism | 37.54 | 15.76 | 49 | 44354 | 6847 | 29523277 |
Injection site pain | 37.38 | 15.76 | 3 | 44400 | 32443 | 29497681 |
Off label use | 36.93 | 15.76 | 645 | 43758 | 300155 | 29229969 |
Bradycardia | 36.64 | 15.76 | 27 | 44376 | 65602 | 29464522 |
Cardiac disorder | 36.58 | 15.76 | 6 | 44397 | 37257 | 29492867 |
Skin toxicity | 36.26 | 15.76 | 36 | 44367 | 3735 | 29526389 |
Hypertransaminasaemia | 35.75 | 15.76 | 35 | 44368 | 3571 | 29526553 |
Recall phenomenon | 35.70 | 15.76 | 17 | 44386 | 518 | 29529606 |
Right ventricular ejection fraction decreased | 35.10 | 15.76 | 9 | 44394 | 36 | 29530088 |
Dysphagia | 34.81 | 15.76 | 169 | 44234 | 54757 | 29475367 |
Enterocolitis | 34.18 | 15.76 | 46 | 44357 | 6620 | 29523504 |
Hypoglycaemia | 33.97 | 15.76 | 15 | 44388 | 48331 | 29481793 |
Gastrointestinal toxicity | 33.79 | 15.76 | 27 | 44376 | 2104 | 29528020 |
Septic shock | 33.74 | 15.76 | 184 | 44219 | 62376 | 29467748 |
Adrenal insufficiency | 33.49 | 15.76 | 60 | 44343 | 11054 | 29519070 |
Performance status decreased | 32.95 | 15.76 | 34 | 44369 | 3693 | 29526431 |
Agitation | 32.90 | 15.76 | 18 | 44385 | 51286 | 29478838 |
Hallucination | 32.82 | 15.76 | 13 | 44390 | 44699 | 29485425 |
Oxygen saturation decreased | 32.71 | 15.76 | 144 | 44259 | 44793 | 29485331 |
Musculoskeletal stiffness | 32.66 | 15.76 | 8 | 44395 | 37450 | 29492674 |
Gastritis bacterial | 32.21 | 15.76 | 12 | 44391 | 194 | 29529930 |
Teratoma benign | 32.03 | 15.76 | 8 | 44395 | 28 | 29530096 |
Oesophagitis | 31.71 | 15.76 | 61 | 44342 | 11862 | 29518262 |
Tidal volume decreased | 31.20 | 15.76 | 8 | 44395 | 32 | 29530092 |
Neutropenic sepsis | 31.19 | 15.76 | 60 | 44343 | 11667 | 29518457 |
Pulmonary embolism | 31.03 | 15.76 | 209 | 44194 | 76325 | 29453799 |
Condition aggravated | 31.01 | 15.76 | 114 | 44289 | 146181 | 29383943 |
Haemolytic uraemic syndrome | 30.99 | 15.76 | 25 | 44378 | 1975 | 29528149 |
Stomatitis | 30.96 | 15.76 | 124 | 44279 | 36989 | 29493135 |
Brain teratoma | 30.85 | 15.76 | 7 | 44396 | 14 | 29530110 |
Immune-mediated enterocolitis | 30.70 | 15.76 | 23 | 44380 | 1630 | 29528494 |
Therapeutic product effect decreased | 30.62 | 15.76 | 4 | 44399 | 29447 | 29500677 |
Metastases to bone | 30.55 | 15.76 | 54 | 44349 | 9844 | 29520280 |
Bronchospasm | 30.41 | 15.76 | 53 | 44350 | 9556 | 29520568 |
Nail dystrophy | 30.41 | 15.76 | 11 | 44392 | 163 | 29529961 |
Intestinal perforation | 30.14 | 15.76 | 48 | 44355 | 8038 | 29522086 |
Arthralgia | 30.12 | 15.76 | 108 | 44295 | 139509 | 29390615 |
Pneumatosis intestinalis | 30.01 | 15.76 | 30 | 44373 | 3139 | 29526985 |
Blood glucose increased | 29.53 | 15.76 | 27 | 44376 | 58957 | 29471167 |
Neutropenic colitis | 28.89 | 15.76 | 26 | 44377 | 2385 | 29527739 |
Pulmonary toxicity | 28.59 | 15.76 | 36 | 44367 | 4854 | 29525270 |
Disseminated intravascular coagulation | 28.50 | 15.76 | 80 | 44323 | 19900 | 29510224 |
Tumour necrosis | 28.49 | 15.76 | 19 | 44384 | 1118 | 29529006 |
Acute respiratory distress syndrome | 28.10 | 15.76 | 87 | 44316 | 22848 | 29507276 |
Psoriasis | 27.87 | 15.76 | 7 | 44396 | 32220 | 29497904 |
Memory impairment | 27.78 | 15.76 | 10 | 44393 | 36460 | 29493664 |
Periarticular thenar erythema with onycholysis | 27.52 | 15.76 | 5 | 44398 | 0 | 29530124 |
Oesophagopleural fistula | 27.47 | 15.76 | 8 | 44395 | 56 | 29530068 |
Angioedema | 27.47 | 15.76 | 7 | 44396 | 31908 | 29498216 |
Hypoxia | 27.35 | 15.76 | 142 | 44261 | 47237 | 29482887 |
Anaphylactic reaction | 27.03 | 15.76 | 97 | 44306 | 27476 | 29502648 |
Coma | 26.54 | 15.76 | 13 | 44390 | 39437 | 29490687 |
Macular oedema | 26.52 | 15.76 | 25 | 44378 | 2433 | 29527691 |
International normalised ratio increased | 26.43 | 15.76 | 17 | 44386 | 44355 | 29485769 |
Enterocolitis infectious | 26.34 | 15.76 | 19 | 44384 | 1270 | 29528854 |
Myocardial infarction | 26.04 | 15.76 | 82 | 44321 | 110214 | 29419910 |
Rheumatoid arthritis | 25.91 | 15.76 | 8 | 44395 | 32144 | 29497980 |
Confusional state | 25.57 | 15.76 | 102 | 44301 | 127775 | 29402349 |
Peripheral swelling | 25.53 | 15.76 | 35 | 44368 | 63704 | 29466420 |
Eastern Cooperative Oncology Group performance status worsened | 25.34 | 15.76 | 15 | 44388 | 715 | 29529409 |
Dermatitis acneiform | 25.32 | 15.76 | 36 | 44367 | 5455 | 29524669 |
Dizziness | 25.20 | 15.76 | 174 | 44229 | 189510 | 29340614 |
Pneumoperitoneum | 25.09 | 15.76 | 20 | 44383 | 1553 | 29528571 |
Wrong technique in product usage process | 25.01 | 15.76 | 8 | 44395 | 31420 | 29498704 |
Fluid retention | 24.98 | 15.76 | 3 | 44400 | 23557 | 29506567 |
Stress cardiomyopathy | 24.53 | 15.76 | 20 | 44383 | 1604 | 29528520 |
Blood pressure increased | 24.41 | 15.76 | 46 | 44357 | 73757 | 29456367 |
Abnormal behaviour | 24.39 | 15.76 | 3 | 44400 | 23124 | 29507000 |
Muscle spasms | 23.87 | 15.76 | 38 | 44365 | 65044 | 29465080 |
Feeling abnormal | 23.78 | 15.76 | 28 | 44375 | 54417 | 29475707 |
Taeniasis | 23.68 | 15.76 | 7 | 44396 | 52 | 29530072 |
Influenza | 23.67 | 15.76 | 17 | 44386 | 41864 | 29488260 |
Incorrect dose administered | 23.54 | 15.76 | 10 | 44393 | 32974 | 29497150 |
Irritability | 23.05 | 15.76 | 3 | 44400 | 22149 | 29507975 |
Loss of personal independence in daily activities | 23.04 | 15.76 | 5 | 44398 | 25435 | 29504689 |
Metabolic acidosis | 23.02 | 15.76 | 14 | 44389 | 37648 | 29492476 |
Urticaria | 22.93 | 15.76 | 29 | 44374 | 54631 | 29475493 |
Metastases to skin | 22.75 | 15.76 | 11 | 44392 | 347 | 29529777 |
Dysarthria | 22.66 | 15.76 | 9 | 44394 | 30902 | 29499222 |
Pancreatic enzyme abnormality | 22.65 | 15.76 | 6 | 44397 | 28 | 29530096 |
Adrenocorticotropic hormone deficiency | 22.56 | 15.76 | 13 | 44390 | 589 | 29529535 |
Non-small cell lung cancer | 22.49 | 15.76 | 25 | 44378 | 2956 | 29527168 |
Tumour pseudoprogression | 22.23 | 15.76 | 11 | 44392 | 365 | 29529759 |
Sense of oppression | 22.22 | 15.76 | 12 | 44391 | 479 | 29529645 |
Cytomegalovirus infection | 22.21 | 15.76 | 4 | 44399 | 23211 | 29506913 |
Discontinued product administered | 21.72 | 15.76 | 5 | 44398 | 11 | 29530113 |
Asthma | 21.52 | 15.76 | 12 | 44391 | 33837 | 29496287 |
Inappropriate schedule of product administration | 21.50 | 15.76 | 21 | 44382 | 44451 | 29485673 |
Seizure | 21.44 | 15.76 | 70 | 44333 | 93053 | 29437071 |
Hyperkalaemia | 21.44 | 15.76 | 37 | 44366 | 61355 | 29468769 |
Infectious pleural effusion | 21.31 | 15.76 | 20 | 44383 | 1936 | 29528188 |
Prostate cancer | 21.21 | 15.76 | 6 | 44397 | 25521 | 29504603 |
Feeling hot | 21.10 | 15.76 | 61 | 44342 | 15427 | 29514697 |
Metastases to lymph nodes | 21.02 | 15.76 | 28 | 44375 | 3989 | 29526135 |
Paronychia | 20.97 | 15.76 | 24 | 44379 | 2929 | 29527195 |
Rhabdomyolysis | 20.91 | 15.76 | 37 | 44366 | 60771 | 29469353 |
Psychotic disorder | 20.61 | 15.76 | 3 | 44400 | 20351 | 29509773 |
Heart rate decreased | 20.43 | 15.76 | 6 | 44397 | 24906 | 29505218 |
Oesophagobronchial fistula | 20.38 | 15.76 | 8 | 44395 | 150 | 29529974 |
Lung disorder | 20.37 | 15.76 | 95 | 44308 | 30267 | 29499857 |
Lactic acidosis | 20.30 | 15.76 | 10 | 44393 | 30237 | 29499887 |
Chronic kidney disease | 20.29 | 15.76 | 15 | 44388 | 36401 | 29493723 |
Pericardial effusion | 20.27 | 15.76 | 74 | 44329 | 21134 | 29508990 |
Cachexia | 20.06 | 15.76 | 35 | 44368 | 6314 | 29523810 |
Immune-mediated hepatic disorder | 19.96 | 15.76 | 10 | 44393 | 341 | 29529783 |
Lung abscess | 19.87 | 15.76 | 21 | 44382 | 2345 | 29527779 |
Disturbance in attention | 19.84 | 15.76 | 4 | 44399 | 21420 | 29508704 |
Pulmonary artery occlusion | 19.78 | 15.76 | 4 | 44399 | 3 | 29530121 |
Blood thyroid stimulating hormone abnormal | 19.44 | 15.76 | 9 | 44394 | 257 | 29529867 |
Gastric perforation | 19.43 | 15.76 | 20 | 44383 | 2166 | 29527958 |
Metastases to peritoneum | 19.42 | 15.76 | 17 | 44386 | 1503 | 29528621 |
Lymphangiosis carcinomatosa | 18.99 | 15.76 | 13 | 44390 | 799 | 29529325 |
Lung squamous cell carcinoma metastatic | 18.90 | 15.76 | 6 | 44397 | 58 | 29530066 |
Metastases to kidney | 18.84 | 15.76 | 9 | 44394 | 276 | 29529848 |
Supraventricular tachycardia | 18.67 | 15.76 | 44 | 44359 | 9840 | 29520284 |
Product use in unapproved indication | 18.64 | 15.76 | 206 | 44197 | 86669 | 29443455 |
Radiation skin injury | 18.59 | 15.76 | 12 | 44391 | 668 | 29529456 |
Thrombocytosis | 18.52 | 15.76 | 24 | 44379 | 3329 | 29526795 |
Tumour marker increased | 18.42 | 15.76 | 11 | 44392 | 533 | 29529591 |
Blastic plasmacytoid dendritic cell neoplasia | 18.37 | 15.76 | 6 | 44397 | 64 | 29530060 |
Tumour lysis syndrome | 18.26 | 15.76 | 54 | 44349 | 13830 | 29516294 |
Sinusitis | 18.06 | 15.76 | 15 | 44388 | 34335 | 29495789 |
Ileus | 17.98 | 15.76 | 55 | 44348 | 14347 | 29515777 |
Subdural haematoma | 17.70 | 15.76 | 3 | 44400 | 18190 | 29511934 |
Blood creatine phosphokinase increased | 17.64 | 15.76 | 21 | 44382 | 40623 | 29489501 |
Metastases to the mediastinum | 17.52 | 15.76 | 8 | 44395 | 221 | 29529903 |
Hypophysitis | 17.47 | 15.76 | 18 | 44385 | 1952 | 29528172 |
Second primary malignancy | 17.46 | 15.76 | 34 | 44369 | 6671 | 29523453 |
Vascular pseudoaneurysm ruptured | 17.37 | 15.76 | 6 | 44397 | 77 | 29530047 |
Coronary artery aneurysm | 17.37 | 15.76 | 6 | 44397 | 77 | 29530047 |
Cataract | 17.27 | 15.76 | 6 | 44397 | 22372 | 29507752 |
Portal venous gas | 17.24 | 15.76 | 9 | 44394 | 335 | 29529789 |
Enteritis | 17.15 | 15.76 | 34 | 44369 | 6757 | 29523367 |
Pulmonary cavitation | 17.06 | 15.76 | 12 | 44391 | 771 | 29529353 |
Eosinophilia | 17.00 | 15.76 | 6 | 44397 | 22155 | 29507969 |
Abdominal pain | 16.78 | 15.76 | 291 | 44112 | 135066 | 29395058 |
Transient ischaemic attack | 16.69 | 15.76 | 7 | 44396 | 23263 | 29506861 |
Anaphylactoid shock | 16.62 | 15.76 | 9 | 44394 | 361 | 29529763 |
Nasal congestion | 16.52 | 15.76 | 4 | 44399 | 18875 | 29511249 |
Upper gastrointestinal perforation | 16.51 | 15.76 | 3 | 44400 | 0 | 29530124 |
Balance disorder | 16.44 | 15.76 | 18 | 44385 | 36152 | 29493972 |
Erythema multiforme | 16.41 | 15.76 | 36 | 44367 | 7681 | 29522443 |
Hiccups | 16.28 | 15.76 | 39 | 44364 | 8814 | 29521310 |
Product use issue | 16.20 | 15.76 | 33 | 44370 | 51411 | 29478713 |
Tachycardia | 16.13 | 15.76 | 173 | 44230 | 72237 | 29457887 |
Herpes zoster | 15.96 | 15.76 | 13 | 44390 | 30039 | 29500085 |
Pneumonia bacterial | 15.95 | 15.76 | 40 | 44363 | 9303 | 29520821 |
Pain in extremity | 15.80 | 15.76 | 99 | 44304 | 110334 | 29419790 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 1648.53 | 12.23 | 1687 | 149897 | 115838 | 64231310 |
Neutropenia | 1598.31 | 12.23 | 2362 | 149222 | 237262 | 64109886 |
Malignant neoplasm progression | 1488.94 | 12.23 | 1568 | 150016 | 111303 | 64235845 |
Febrile neutropenia | 1045.49 | 12.23 | 1704 | 149880 | 185953 | 64161195 |
Erythema | 1000.77 | 12.23 | 1668 | 149916 | 185402 | 64161746 |
Flushing | 916.25 | 12.23 | 1024 | 150560 | 77624 | 64269524 |
Disease progression | 794.46 | 12.23 | 1291 | 150293 | 140389 | 64206759 |
Anaemia | 754.66 | 12.23 | 2273 | 149311 | 376407 | 63970741 |
Metastases to liver | 717.93 | 12.23 | 531 | 151053 | 23410 | 64323738 |
Metastases to bone | 706.09 | 12.23 | 494 | 151090 | 19941 | 64327207 |
Neutrophil count decreased | 664.31 | 12.23 | 862 | 150722 | 76334 | 64270814 |
Dyspnoea | 600.50 | 12.23 | 3289 | 148295 | 715385 | 63631763 |
Metastases to lung | 539.01 | 12.23 | 374 | 151210 | 14890 | 64332258 |
Myelosuppression | 525.54 | 12.23 | 441 | 151143 | 23389 | 64323759 |
Polyneuropathy | 501.50 | 12.23 | 398 | 151186 | 19496 | 64327652 |
Completed suicide | 500.02 | 12.23 | 5 | 151579 | 224409 | 64122739 |
Leukopenia | 485.54 | 12.23 | 861 | 150723 | 100381 | 64246767 |
Thrombocytopenia | 482.44 | 12.23 | 1383 | 150201 | 222418 | 64124730 |
Pneumonitis | 478.45 | 12.23 | 591 | 150993 | 49774 | 64297374 |
Interstitial lung disease | 474.94 | 12.23 | 836 | 150748 | 96896 | 64250252 |
Drug ineffective | 455.56 | 12.23 | 801 | 150783 | 839446 | 63507702 |
Peripheral sensory neuropathy | 449.85 | 12.23 | 299 | 151285 | 11079 | 64336069 |
Palmar-plantar erythrodysaesthesia syndrome | 434.77 | 12.23 | 431 | 151153 | 28388 | 64318760 |
Neoplasm progression | 428.80 | 12.23 | 505 | 151079 | 40459 | 64306689 |
Cystoid macular oedema | 416.92 | 12.23 | 157 | 151427 | 1617 | 64345531 |
Metastases to central nervous system | 391.25 | 12.23 | 297 | 151287 | 13615 | 64333533 |
Mucosal inflammation | 378.71 | 12.23 | 591 | 150993 | 61993 | 64285155 |
Neurotoxicity | 359.23 | 12.23 | 380 | 151204 | 27024 | 64320124 |
Fall | 355.63 | 12.23 | 276 | 151308 | 416550 | 63930598 |
Joint swelling | 345.81 | 12.23 | 48 | 151536 | 215334 | 64131814 |
Haematotoxicity | 342.27 | 12.23 | 266 | 151318 | 12630 | 64334518 |
Bone marrow failure | 337.45 | 12.23 | 486 | 151098 | 47466 | 64299682 |
Product dose omission issue | 330.74 | 12.23 | 36 | 151548 | 194711 | 64152437 |
Chest discomfort | 319.30 | 12.23 | 786 | 150798 | 115320 | 64231828 |
Acute myeloid leukaemia | 313.32 | 12.23 | 354 | 151230 | 27109 | 64320039 |
Rheumatoid arthritis | 310.34 | 12.23 | 19 | 151565 | 164275 | 64182873 |
Metastases to lymph nodes | 308.70 | 12.23 | 214 | 151370 | 8503 | 64338645 |
Feeling hot | 302.76 | 12.23 | 450 | 151134 | 45213 | 64301935 |
Anaphylactic shock | 296.21 | 12.23 | 361 | 151223 | 29967 | 64317181 |
Drug abuse | 290 | 12.23 | 4 | 151580 | 132370 | 64214778 |
General physical health deterioration | 287.94 | 12.23 | 1094 | 150490 | 203331 | 64143817 |
Onycholysis | 270.18 | 12.23 | 112 | 151472 | 1514 | 64345634 |
Bronchospasm | 256.77 | 12.23 | 285 | 151299 | 21397 | 64325751 |
Pseudocirrhosis | 254.78 | 12.23 | 84 | 151500 | 561 | 64346587 |
Nausea | 238.90 | 12.23 | 2855 | 148729 | 782945 | 63564203 |
Weight increased | 228.11 | 12.23 | 108 | 151476 | 213240 | 64133908 |
Headache | 227.71 | 12.23 | 574 | 151010 | 528893 | 63818255 |
Toxicity to various agents | 227.00 | 12.23 | 314 | 151270 | 363199 | 63983949 |
Overdose | 222.61 | 12.23 | 51 | 151533 | 159515 | 64187633 |
Condition aggravated | 219.50 | 12.23 | 335 | 151249 | 372091 | 63975057 |
Gastrointestinal perforation | 217.93 | 12.23 | 144 | 151440 | 5280 | 64341868 |
Cholangitis | 213.89 | 12.23 | 188 | 151396 | 10614 | 64336534 |
Contraindicated product administered | 208.10 | 12.23 | 11 | 151573 | 107818 | 64239330 |
Ascites | 206.84 | 12.23 | 453 | 151131 | 61548 | 64285600 |
Metastases to peritoneum | 205.74 | 12.23 | 119 | 151465 | 3428 | 64343720 |
Vomiting | 204.46 | 12.23 | 2084 | 149500 | 549033 | 63798115 |
Skin toxicity | 201.37 | 12.23 | 148 | 151436 | 6454 | 64340694 |
Therapeutic product effect decreased | 199.17 | 12.23 | 20 | 151564 | 115331 | 64231817 |
Back pain | 199.16 | 12.23 | 1133 | 150451 | 249038 | 64098110 |
Musculoskeletal stiffness | 196.37 | 12.23 | 28 | 151556 | 123178 | 64223970 |
Synovitis | 194.77 | 12.23 | 9 | 151575 | 99081 | 64248067 |
Pyrexia | 191.92 | 12.23 | 2080 | 149504 | 556564 | 63790584 |
Hypertension | 190.75 | 12.23 | 1150 | 150434 | 258111 | 64089037 |
Diarrhoea | 190.01 | 12.23 | 2557 | 149027 | 720147 | 63627001 |
Arthropathy | 189.31 | 12.23 | 29 | 151555 | 120938 | 64226210 |
White blood cell count decreased | 188.72 | 12.23 | 803 | 150781 | 157034 | 64190114 |
Ejection fraction decreased | 187.53 | 12.23 | 281 | 151303 | 28426 | 64318722 |
Sinusitis | 185.74 | 12.23 | 56 | 151528 | 145872 | 64201276 |
Proteinuria | 184.86 | 12.23 | 274 | 151310 | 27449 | 64319699 |
Drug interaction | 183.80 | 12.23 | 358 | 151226 | 361725 | 63985423 |
Pleural effusion | 182.70 | 12.23 | 683 | 150901 | 125876 | 64221272 |
Breast cancer metastatic | 181.86 | 12.23 | 144 | 151440 | 7025 | 64340123 |
Second primary malignancy | 181.39 | 12.23 | 182 | 151402 | 12155 | 64334993 |
Hypertransaminasaemia | 177.20 | 12.23 | 142 | 151442 | 7049 | 64340099 |
Injection site pain | 173.67 | 12.23 | 27 | 151557 | 111381 | 64235767 |
Platelet count decreased | 169.61 | 12.23 | 812 | 150772 | 166899 | 64180249 |
Infusion related reaction | 169.02 | 12.23 | 800 | 150784 | 163667 | 64183481 |
Hypersensitivity | 165.76 | 12.23 | 904 | 150680 | 195548 | 64151600 |
Therapy partial responder | 161.47 | 12.23 | 157 | 151427 | 10091 | 64337057 |
Biliary tract infection | 159.69 | 12.23 | 66 | 151518 | 885 | 64346263 |
Sense of oppression | 157.34 | 12.23 | 74 | 151510 | 1373 | 64345775 |
Depression | 155.17 | 12.23 | 122 | 151462 | 183169 | 64163979 |
Somnolence | 153.77 | 12.23 | 151 | 151433 | 203494 | 64143654 |
Arthralgia | 151.27 | 12.23 | 533 | 151051 | 441727 | 63905421 |
Suicide attempt | 148.04 | 12.23 | 4 | 151580 | 71003 | 64276145 |
Cardiac dysfunction | 145.92 | 12.23 | 91 | 151493 | 3015 | 64344133 |
Myelodysplastic syndrome | 145.70 | 12.23 | 245 | 151339 | 27334 | 64319814 |
Paraesthesia | 145.28 | 12.23 | 664 | 150920 | 133858 | 64213290 |
Abdominal discomfort | 139.01 | 12.23 | 134 | 151450 | 182188 | 64164960 |
Lymphangiosis carcinomatosa | 138.37 | 12.23 | 73 | 151511 | 1748 | 64345400 |
Nasopharyngitis | 138.33 | 12.23 | 154 | 151430 | 195919 | 64151229 |
Embolism | 138.31 | 12.23 | 157 | 151427 | 12078 | 64335070 |
Epistaxis | 136.95 | 12.23 | 524 | 151060 | 97607 | 64249541 |
Peripheral swelling | 136.14 | 12.23 | 175 | 151409 | 208978 | 64138170 |
Pain | 136.08 | 12.23 | 755 | 150829 | 552756 | 63794392 |
Hospitalisation | 135.30 | 12.23 | 11 | 151573 | 75196 | 64271952 |
Oxygen saturation decreased | 134.06 | 12.23 | 553 | 151031 | 106623 | 64240525 |
Glossodynia | 133.57 | 12.23 | 4 | 151580 | 64692 | 64282456 |
Product use issue | 133.51 | 12.23 | 97 | 151487 | 151618 | 64195530 |
Radiation pneumonitis | 132.84 | 12.23 | 88 | 151496 | 3240 | 64343908 |
Swelling | 126.56 | 12.23 | 114 | 151470 | 160104 | 64187044 |
Metastases to meninges | 126.04 | 12.23 | 80 | 151504 | 2735 | 64344413 |
Pemphigus | 124.43 | 12.23 | 4 | 151580 | 60697 | 64286451 |
Abdominal pain | 123.53 | 12.23 | 1198 | 150386 | 311177 | 64035971 |
Drug intolerance | 121.61 | 12.23 | 158 | 151426 | 187834 | 64159314 |
Intentional product misuse | 121.04 | 12.23 | 14 | 151570 | 72281 | 64274867 |
Gastrointestinal toxicity | 120.42 | 12.23 | 100 | 151484 | 5222 | 64341926 |
Ovarian cancer recurrent | 120.21 | 12.23 | 41 | 151543 | 308 | 64346840 |
Nail toxicity | 119.41 | 12.23 | 41 | 151543 | 315 | 64346833 |
Dehydration | 118.72 | 12.23 | 894 | 150690 | 215869 | 64131279 |
Confusional state | 118.35 | 12.23 | 275 | 151309 | 260869 | 64086279 |
Alopecia | 117.28 | 12.23 | 728 | 150856 | 164962 | 64182186 |
Mobility decreased | 116.59 | 12.23 | 29 | 151555 | 85811 | 64261337 |
Decreased appetite | 115.25 | 12.23 | 1087 | 150497 | 280202 | 64066946 |
Tumour haemorrhage | 114.95 | 12.23 | 82 | 151502 | 3411 | 64343737 |
Recall phenomenon | 114.19 | 12.23 | 53 | 151531 | 953 | 64346195 |
Systemic lupus erythematosus | 113.95 | 12.23 | 22 | 151562 | 77590 | 64269558 |
Insomnia | 113.46 | 12.23 | 181 | 151403 | 197655 | 64149493 |
Metastases to skin | 112.58 | 12.23 | 59 | 151525 | 1393 | 64345755 |
Throat tightness | 112.19 | 12.23 | 198 | 151386 | 22962 | 64324186 |
Nail disorder | 111.94 | 12.23 | 119 | 151465 | 8505 | 64338643 |
Pulmonary embolism | 111.82 | 12.23 | 656 | 150928 | 145700 | 64201448 |
Pneumothorax | 110.38 | 12.23 | 202 | 151382 | 24096 | 64323052 |
Hypoglycaemia | 109.90 | 12.23 | 37 | 151547 | 89855 | 64257293 |
Osteonecrosis of jaw | 108.69 | 12.23 | 269 | 151315 | 39556 | 64307592 |
Psoriasis | 108.12 | 12.23 | 19 | 151565 | 71684 | 64275464 |
Neutropenic sepsis | 107.65 | 12.23 | 195 | 151389 | 23077 | 64324071 |
Injection site erythema | 106.24 | 12.23 | 19 | 151565 | 70781 | 64276367 |
Influenza | 106.21 | 12.23 | 59 | 151525 | 106472 | 64240676 |
Contusion | 105.39 | 12.23 | 69 | 151515 | 113896 | 64233252 |
Cyanosis | 104.22 | 12.23 | 187 | 151397 | 21968 | 64325180 |
Hypoxia | 102.58 | 12.23 | 445 | 151139 | 87704 | 64259444 |
Pancytopenia | 99.11 | 12.23 | 626 | 150958 | 142683 | 64204465 |
Migraine | 98.09 | 12.23 | 15 | 151569 | 62662 | 64284486 |
Coronary artery disease | 98 | 12.23 | 13 | 151571 | 60420 | 64286728 |
Loss of personal independence in daily activities | 97.39 | 12.23 | 25 | 151559 | 72429 | 64274719 |
Tachycardia | 97.08 | 12.23 | 643 | 150941 | 148936 | 64198212 |
Blood cholesterol increased | 96.91 | 12.23 | 5 | 151579 | 50061 | 64297087 |
Arthritis | 96.53 | 12.23 | 38 | 151546 | 83776 | 64263372 |
Immune-mediated hepatitis | 94.98 | 12.23 | 64 | 151520 | 2425 | 64344723 |
Nail discolouration | 94.73 | 12.23 | 64 | 151520 | 2436 | 64344712 |
Drug reaction with eosinophilia and systemic symptoms | 94.61 | 12.23 | 9 | 151575 | 54208 | 64292940 |
Bone pain | 94.53 | 12.23 | 286 | 151298 | 47286 | 64299862 |
Asthenia | 91.61 | 12.23 | 1463 | 150121 | 426581 | 63920567 |
Electrocardiogram QT prolonged | 91.53 | 12.23 | 36 | 151548 | 79412 | 64267736 |
Peripheral motor neuropathy | 91.52 | 12.23 | 67 | 151517 | 2903 | 64344245 |
Myocardial infarction | 90.15 | 12.23 | 157 | 151427 | 165664 | 64181484 |
Hepatic enzyme increased | 89.50 | 12.23 | 104 | 151480 | 129839 | 64217309 |
Blood pressure fluctuation | 89.49 | 12.23 | 9 | 151575 | 51862 | 64295286 |
Inappropriate schedule of product administration | 89.30 | 12.23 | 53 | 151531 | 92233 | 64254915 |
Feeling abnormal | 88.75 | 12.23 | 110 | 151474 | 133492 | 64213656 |
Incorrect dose administered | 87.58 | 12.23 | 18 | 151566 | 60747 | 64286401 |
Bradycardia | 86.50 | 12.23 | 90 | 151494 | 118129 | 64229019 |
Asthma | 86.23 | 12.23 | 59 | 151525 | 95166 | 64251982 |
Breast cancer recurrent | 85.83 | 12.23 | 61 | 151523 | 2522 | 64344626 |
Gait disturbance | 85.65 | 12.23 | 172 | 151412 | 171983 | 64175165 |
Suicidal ideation | 85.61 | 12.23 | 25 | 151559 | 66517 | 64280631 |
Hallucination | 85.49 | 12.23 | 32 | 151552 | 72756 | 64274392 |
Dysaesthesia | 85.28 | 12.23 | 80 | 151504 | 4915 | 64342233 |
Intestinal perforation | 82.16 | 12.23 | 137 | 151447 | 15176 | 64331972 |
Memory impairment | 81.79 | 12.23 | 50 | 151534 | 85632 | 64261516 |
Thrombotic microangiopathy | 81.45 | 12.23 | 143 | 151441 | 16512 | 64330636 |
Ileus | 80.21 | 12.23 | 171 | 151413 | 22795 | 64324353 |
Rhabdomyolysis | 80.20 | 12.23 | 59 | 151525 | 91667 | 64255481 |
Coma | 79.71 | 12.23 | 54 | 151530 | 87561 | 64259587 |
Cardiotoxicity | 79.46 | 12.23 | 109 | 151475 | 10165 | 64336983 |
Anaphylactic reaction | 79.39 | 12.23 | 346 | 151238 | 68318 | 64278830 |
Colitis | 78.31 | 12.23 | 309 | 151275 | 58365 | 64288783 |
Drug hypersensitivity | 78.22 | 12.23 | 291 | 151293 | 237524 | 64109624 |
Injection site reaction | 78.20 | 12.23 | 9 | 151575 | 46655 | 64300493 |
Stomatitis | 77.76 | 12.23 | 482 | 151102 | 109123 | 64238025 |
Tumour necrosis | 77.59 | 12.23 | 49 | 151535 | 1660 | 64345488 |
Radiation oesophagitis | 77.24 | 12.23 | 34 | 151550 | 537 | 64346611 |
Helicobacter infection | 76.97 | 12.23 | 3 | 151581 | 38359 | 64308789 |
Performance status decreased | 76.78 | 12.23 | 78 | 151506 | 5286 | 64341862 |
Wound | 76.74 | 12.23 | 42 | 151542 | 76435 | 64270713 |
Hepatic atrophy | 76.70 | 12.23 | 31 | 151553 | 391 | 64346757 |
Acute promyelocytic leukaemia | 76.36 | 12.23 | 45 | 151539 | 1343 | 64345805 |
Injection site pruritus | 75.76 | 12.23 | 3 | 151581 | 37823 | 64309325 |
Anxiety | 74.05 | 12.23 | 237 | 151347 | 202412 | 64144736 |
Fluid retention | 72.05 | 12.23 | 25 | 151559 | 59581 | 64287567 |
Exposure during pregnancy | 71.84 | 12.23 | 47 | 151537 | 77628 | 64269520 |
Pneumocystis jirovecii pneumonia | 70.54 | 12.23 | 182 | 151402 | 27452 | 64319696 |
International normalised ratio increased | 70.42 | 12.23 | 50 | 151534 | 79117 | 64268031 |
Sepsis | 70.25 | 12.23 | 839 | 150745 | 229502 | 64117646 |
Dizziness | 69.08 | 12.23 | 662 | 150922 | 429501 | 63917647 |
Lactic acidosis | 68.83 | 12.23 | 29 | 151555 | 61381 | 64285767 |
Irritable bowel syndrome | 68.52 | 12.23 | 5 | 151579 | 37364 | 64309784 |
Tumour marker increased | 68.21 | 12.23 | 60 | 151524 | 3390 | 64343758 |
Large intestine perforation | 67.94 | 12.23 | 113 | 151471 | 12491 | 64334657 |
Hypokalaemia | 67.91 | 12.23 | 505 | 151079 | 121398 | 64225750 |
Fibromyalgia | 67.82 | 12.23 | 4 | 151580 | 35727 | 64311421 |
Treatment failure | 67.76 | 12.23 | 106 | 151478 | 116710 | 64230438 |
Plasma cell myeloma | 67.76 | 12.23 | 13 | 151571 | 46062 | 64301086 |
Metastases to kidney | 67.29 | 12.23 | 29 | 151555 | 434 | 64346714 |
Serotonin syndrome | 67.29 | 12.23 | 7 | 151577 | 39275 | 64307873 |
Subileus | 66.95 | 12.23 | 70 | 151514 | 4907 | 64342241 |
Posterior reversible encephalopathy syndrome | 66.89 | 12.23 | 159 | 151425 | 22787 | 64324361 |
Duodenal ulcer perforation | 65.34 | 12.23 | 4 | 151580 | 34621 | 64312527 |
Cardiac failure congestive | 65.33 | 12.23 | 130 | 151454 | 130450 | 64216698 |
Scleroderma-like reaction | 65.19 | 12.23 | 20 | 151564 | 102 | 64347046 |
Alveolitis | 64.71 | 12.23 | 60 | 151524 | 3632 | 64343516 |
Macular oedema | 64.66 | 12.23 | 68 | 151516 | 4799 | 64342349 |
Irritability | 64.38 | 12.23 | 6 | 151578 | 36740 | 64310408 |
Metastatic neoplasm | 64.32 | 12.23 | 65 | 151519 | 4377 | 64342771 |
Metabolic acidosis | 64.19 | 12.23 | 44 | 151540 | 70914 | 64276234 |
Aggression | 63.98 | 12.23 | 15 | 151569 | 46217 | 64300931 |
PIK3CA-activated mutation | 63.79 | 12.23 | 29 | 151555 | 496 | 64346652 |
Injury | 63.47 | 12.23 | 26 | 151558 | 55966 | 64291182 |
Metastases to spine | 63.45 | 12.23 | 59 | 151525 | 3584 | 64343564 |
Muscle spasms | 63.42 | 12.23 | 149 | 151435 | 140874 | 64206274 |
Metastases to the mediastinum | 63.32 | 12.23 | 29 | 151555 | 505 | 64346643 |
Metastasis | 62.54 | 12.23 | 72 | 151512 | 5623 | 64341525 |
Hyperaemia | 61.49 | 12.23 | 51 | 151533 | 2658 | 64344490 |
Anaphylactoid reaction | 60.82 | 12.23 | 65 | 151519 | 4673 | 64342475 |
Nephrolithiasis | 60.80 | 12.23 | 14 | 151570 | 43669 | 64303479 |
Urogenital fistula | 60.51 | 12.23 | 18 | 151566 | 81 | 64347067 |
Bronchial fistula | 60.42 | 12.23 | 21 | 151563 | 168 | 64346980 |
Pain in extremity | 60.11 | 12.23 | 441 | 151143 | 302644 | 64044504 |
Nasal congestion | 59.51 | 12.23 | 33 | 151551 | 59625 | 64287523 |
Malignant pleural effusion | 59.46 | 12.23 | 52 | 151532 | 2915 | 64344233 |
Cataract | 59.42 | 12.23 | 23 | 151561 | 51239 | 64295909 |
Hypertensive crisis | 59.31 | 12.23 | 132 | 151452 | 18116 | 64329032 |
Pericarditis | 58.94 | 12.23 | 37 | 151547 | 62479 | 64284669 |
Blister | 58.82 | 12.23 | 62 | 151522 | 80905 | 64266243 |
Osteoarthritis | 57.66 | 12.23 | 39 | 151545 | 63297 | 64283851 |
Accidental overdose | 57.43 | 12.23 | 6 | 151578 | 33551 | 64313597 |
Cardiomyopathy | 56.67 | 12.23 | 159 | 151425 | 25197 | 64321951 |
Cholangitis sclerosing | 56.23 | 12.23 | 42 | 151542 | 1877 | 64345271 |
C-reactive protein abnormal | 55.91 | 12.23 | 3 | 151581 | 29044 | 64318104 |
Acute myelomonocytic leukaemia | 55.12 | 12.23 | 22 | 151562 | 268 | 64346880 |
Psychotic disorder | 54.74 | 12.23 | 8 | 151576 | 34570 | 64312578 |
Bronchostenosis | 54.60 | 12.23 | 27 | 151557 | 562 | 64346586 |
Basal cell carcinoma | 54.12 | 12.23 | 5 | 151579 | 30833 | 64316315 |
Bronchitis | 53.76 | 12.23 | 109 | 151475 | 108634 | 64238514 |
Paronychia | 53.44 | 12.23 | 71 | 151513 | 6421 | 64340727 |
Eosinophilia | 53.40 | 12.23 | 12 | 151572 | 38064 | 64309084 |
Computerised tomogram thorax abnormal | 53.08 | 12.23 | 41 | 151543 | 1928 | 64345220 |
Malignant ascites | 52.81 | 12.23 | 32 | 151552 | 1006 | 64346142 |
Urticaria | 52.60 | 12.23 | 174 | 151410 | 147143 | 64200005 |
Medication error | 52.26 | 12.23 | 26 | 151558 | 49940 | 64297208 |
Sleep apnoea syndrome | 51.92 | 12.23 | 5 | 151579 | 29827 | 64317321 |
Metastases to pleura | 51.85 | 12.23 | 34 | 151550 | 1230 | 64345918 |
Nail dystrophy | 51.79 | 12.23 | 29 | 151555 | 784 | 64346364 |
Secondary cerebellar degeneration | 51.72 | 12.23 | 14 | 151570 | 41 | 64347107 |
Enterocolitis infectious | 51.02 | 12.23 | 44 | 151540 | 2420 | 64344728 |
Lymphoedema | 50.99 | 12.23 | 87 | 151497 | 9818 | 64337330 |
Oesophagitis | 50.68 | 12.23 | 138 | 151446 | 21492 | 64325656 |
Dyskinesia | 50.29 | 12.23 | 15 | 151569 | 39373 | 64307775 |
Lower respiratory tract infection | 50.11 | 12.23 | 91 | 151493 | 94523 | 64252625 |
Acute interstitial pneumonitis | 50.00 | 12.23 | 31 | 151553 | 1016 | 64346132 |
Oesophagobronchial fistula | 49.83 | 12.23 | 19 | 151565 | 203 | 64346945 |
Product prescribing error | 49.69 | 12.23 | 11 | 151573 | 35258 | 64311890 |
Cytomegalovirus infection | 49.67 | 12.23 | 13 | 151571 | 37186 | 64309962 |
Disseminated intravascular coagulation | 49.49 | 12.23 | 178 | 151406 | 32170 | 64314978 |
Carbohydrate antigen 125 increased | 49.49 | 12.23 | 39 | 151545 | 1889 | 64345259 |
Wrong technique in product usage process | 49.19 | 12.23 | 48 | 151536 | 64926 | 64282222 |
Swollen tongue | 49.05 | 12.23 | 11 | 151573 | 34943 | 64312205 |
Unevaluable event | 48.83 | 12.23 | 29 | 151555 | 50460 | 64296688 |
Pancreatic carcinoma metastatic | 48.73 | 12.23 | 50 | 151534 | 3428 | 64343720 |
Left ventricular dysfunction | 47.82 | 12.23 | 116 | 151468 | 16838 | 64330310 |
Drug withdrawal syndrome | 47.81 | 12.23 | 8 | 151576 | 31283 | 64315865 |
Hyperkalaemia | 47.78 | 12.23 | 104 | 151480 | 101025 | 64246123 |
Haemoptysis | 47.71 | 12.23 | 235 | 151349 | 48813 | 64298335 |
Pulmonary arterial hypertension | 47.66 | 12.23 | 3 | 151581 | 25364 | 64321784 |
Tremor | 47.65 | 12.23 | 183 | 151401 | 148047 | 64199101 |
Drug level increased | 47.51 | 12.23 | 11 | 151573 | 34185 | 64312963 |
Suffocation feeling | 47.36 | 12.23 | 35 | 151549 | 1539 | 64345609 |
Laryngospasm | 47.32 | 12.23 | 49 | 151535 | 3396 | 64343752 |
Palmar erythema | 46.95 | 12.23 | 36 | 151548 | 1674 | 64345474 |
Osteoporosis | 46.95 | 12.23 | 20 | 151564 | 42060 | 64305088 |
Treatment noncompliance | 46.42 | 12.23 | 22 | 151562 | 43460 | 64303688 |
Device related infection | 46.41 | 12.23 | 168 | 151416 | 30458 | 64316690 |
Haemolytic uraemic syndrome | 46.13 | 12.23 | 52 | 151532 | 3969 | 64343179 |
Pericardial effusion | 45.51 | 12.23 | 198 | 151386 | 39056 | 64308092 |
Neutropenic colitis | 45.47 | 12.23 | 55 | 151529 | 4526 | 64342622 |
Choking sensation | 44.51 | 12.23 | 48 | 151536 | 3487 | 64343661 |
Stress | 44.36 | 12.23 | 46 | 151538 | 60488 | 64286660 |
Type I hypersensitivity | 44.07 | 12.23 | 48 | 151536 | 3526 | 64343622 |
Carbohydrate antigen 15-3 increased | 44.06 | 12.23 | 28 | 151556 | 959 | 64346189 |
Liver abscess | 43.85 | 12.23 | 58 | 151526 | 5222 | 64341926 |
Blood glucose increased | 43.78 | 12.23 | 104 | 151480 | 97969 | 64249179 |
Immune-mediated lung disease | 43.71 | 12.23 | 30 | 151554 | 1172 | 64345976 |
Biliary sepsis | 43.52 | 12.23 | 32 | 151552 | 1396 | 64345752 |
Gastric disorder | 43.44 | 12.23 | 8 | 151576 | 29189 | 64317959 |
Small intestinal perforation | 43.43 | 12.23 | 41 | 151543 | 2539 | 64344609 |
Atelectasis | 43.40 | 12.23 | 152 | 151432 | 27114 | 64320034 |
Hypersensitivity pneumonitis | 42.66 | 12.23 | 45 | 151539 | 3187 | 64343961 |
Road traffic accident | 42.49 | 12.23 | 10 | 151574 | 30735 | 64316413 |
Cachexia | 42.33 | 12.23 | 77 | 151507 | 9140 | 64338008 |
Hot flush | 41.79 | 12.23 | 217 | 151367 | 46018 | 64301130 |
Hepatic failure | 41.42 | 12.23 | 247 | 151337 | 55147 | 64292001 |
Surgery | 41.40 | 12.23 | 8 | 151576 | 28205 | 64318943 |
Blood creatine phosphokinase increased | 41.24 | 12.23 | 46 | 151538 | 58512 | 64288636 |
Pulmonary toxicity | 41.21 | 12.23 | 73 | 151511 | 8488 | 64338660 |
Acute kidney injury | 41.13 | 12.23 | 776 | 150808 | 448464 | 63898684 |
Subdural haematoma | 41.07 | 12.23 | 8 | 151576 | 28046 | 64319102 |
Angioedema | 40.93 | 12.23 | 51 | 151533 | 61770 | 64285378 |
Abnormal behaviour | 40.80 | 12.23 | 14 | 151570 | 33608 | 64313540 |
Limb injury | 40.75 | 12.23 | 4 | 151580 | 23501 | 64323647 |
Tumour lysis syndrome | 40.62 | 12.23 | 119 | 151465 | 19321 | 64327827 |
Recurrent cancer | 40.50 | 12.23 | 38 | 151546 | 2335 | 64344813 |
Eastern Cooperative Oncology Group performance status worsened | 40.38 | 12.23 | 29 | 151555 | 1219 | 64345929 |
Carcinoembryonic antigen increased | 39.91 | 12.23 | 34 | 151550 | 1839 | 64345309 |
Extravasation | 39.72 | 12.23 | 43 | 151541 | 3137 | 64344011 |
Rash pruritic | 39.44 | 12.23 | 46 | 151538 | 57358 | 64289790 |
Head injury | 39.30 | 12.23 | 14 | 151570 | 32828 | 64314320 |
Transient ischaemic attack | 39.16 | 12.23 | 28 | 151556 | 44154 | 64302994 |
Gastrooesophageal reflux disease | 38.86 | 12.23 | 86 | 151498 | 83057 | 64264091 |
COVID-19 | 38.83 | 12.23 | 58 | 151526 | 65082 | 64282066 |
Female genital tract fistula | 38.68 | 12.23 | 39 | 151545 | 2619 | 64344529 |
Agitation | 38.42 | 12.23 | 95 | 151489 | 88272 | 64258876 |
Discomfort | 38.34 | 12.23 | 83 | 151501 | 80795 | 64266353 |
Nervousness | 38.20 | 12.23 | 11 | 151573 | 29545 | 64317603 |
Pleural neoplasm | 38.15 | 12.23 | 16 | 151568 | 223 | 64346925 |
Mental disorder | 37.76 | 12.23 | 8 | 151576 | 26437 | 64320711 |
Respiratory distress | 37.63 | 12.23 | 231 | 151353 | 52100 | 64295048 |
Rectal perforation | 37.56 | 12.23 | 23 | 151561 | 737 | 64346411 |
Metastases to retroperitoneum | 37.28 | 12.23 | 18 | 151566 | 355 | 64346793 |
Maternal exposure during pregnancy | 37.23 | 12.23 | 109 | 151475 | 95775 | 64251373 |
Myoclonus | 37.12 | 12.23 | 7 | 151577 | 25111 | 64322037 |
Capillary permeability increased | 37.02 | 12.23 | 10 | 151574 | 29 | 64347119 |
Capillary leak syndrome | 36.74 | 12.23 | 42 | 151542 | 3255 | 64343893 |
Product administration error | 36.26 | 12.23 | 10 | 151574 | 27633 | 64319515 |
Eczema asteatotic | 36.08 | 12.23 | 19 | 151565 | 453 | 64346695 |
Bone lesion | 36.01 | 12.23 | 52 | 151532 | 5085 | 64342063 |
Cardiac disorder | 35.96 | 12.23 | 47 | 151537 | 55769 | 64291379 |
Pulmonary radiation injury | 35.71 | 12.23 | 11 | 151573 | 57 | 64347091 |
Primary cardiac lymphoma | 35.66 | 12.23 | 9 | 151575 | 18 | 64347130 |
Wheezing | 35.52 | 12.23 | 86 | 151498 | 80493 | 64266655 |
Nightmare | 35.30 | 12.23 | 4 | 151580 | 20989 | 64326159 |
Toxic erythema of chemotherapy | 35.27 | 12.23 | 15 | 151569 | 217 | 64346931 |
Oropharyngeal pain | 35.25 | 12.23 | 100 | 151484 | 88767 | 64258381 |
Acute myocardial infarction | 35.21 | 12.23 | 69 | 151515 | 69649 | 64277499 |
Full blood count abnormal | 35.07 | 12.23 | 13 | 151571 | 29744 | 64317404 |
Pseudomembranous colitis | 34.81 | 12.23 | 50 | 151534 | 4866 | 64342282 |
Stress cardiomyopathy | 34.74 | 12.23 | 71 | 151513 | 9186 | 64337962 |
Constipation | 34.63 | 12.23 | 743 | 150841 | 228594 | 64118554 |
Herpes zoster | 34.53 | 12.23 | 85 | 151499 | 79102 | 64268046 |
Kounis syndrome | 34.50 | 12.23 | 39 | 151545 | 2986 | 64344162 |
Emotional distress | 34.42 | 12.23 | 21 | 151563 | 36017 | 64311131 |
Diabetes mellitus | 34.25 | 12.23 | 65 | 151519 | 66409 | 64280739 |
Tonsillar disorder | 34.10 | 12.23 | 24 | 151560 | 977 | 64346171 |
Dysgeusia | 34.04 | 12.23 | 208 | 151376 | 46839 | 64300309 |
Gout | 33.79 | 12.23 | 5 | 151579 | 21408 | 64325740 |
Eye pain | 33.76 | 12.23 | 16 | 151568 | 31609 | 64315539 |
Metastases to stomach | 33.73 | 12.23 | 15 | 151569 | 243 | 64346905 |
Skin laceration | 33.63 | 12.23 | 8 | 151576 | 24409 | 64322739 |
Ear infection | 33.58 | 12.23 | 7 | 151577 | 23397 | 64323751 |
Chills | 33.42 | 12.23 | 480 | 151104 | 136784 | 64210364 |
Injection site haemorrhage | 33.35 | 12.23 | 8 | 151576 | 24270 | 64322878 |
Tracheal fistula | 33.29 | 12.23 | 12 | 151572 | 108 | 64347040 |
Blood triglycerides increased | 33.27 | 12.23 | 3 | 151581 | 18863 | 64328285 |
Dystonia | 33.26 | 12.23 | 3 | 151581 | 18862 | 64328286 |
Hydronephrosis | 32.97 | 12.23 | 90 | 151494 | 14035 | 64333113 |
Acne | 32.92 | 12.23 | 7 | 151577 | 23074 | 64324074 |
Prostate cancer | 32.71 | 12.23 | 4 | 151580 | 19791 | 64327357 |
Cancer pain | 32.67 | 12.23 | 45 | 151539 | 4212 | 64342936 |
Anastomotic leak | 32.53 | 12.23 | 23 | 151561 | 943 | 64346205 |
Haemorrhage | 32.43 | 12.23 | 88 | 151496 | 79263 | 64267885 |
Radiation skin injury | 32.21 | 12.23 | 26 | 151558 | 1304 | 64345844 |
Hyperhidrosis | 32.09 | 12.23 | 441 | 151143 | 124479 | 64222669 |
Aortitis | 32.05 | 12.23 | 24 | 151560 | 1077 | 64346071 |
Infusion related hypersensitivity reaction | 31.95 | 12.23 | 13 | 151571 | 167 | 64346981 |
Blood uric acid decreased | 31.95 | 12.23 | 24 | 151560 | 1082 | 64346066 |
Bile duct stenosis | 31.28 | 12.23 | 29 | 151555 | 1755 | 64345393 |
Portal hypertension | 31.19 | 12.23 | 54 | 151530 | 6165 | 64340983 |
Fear | 31.17 | 12.23 | 5 | 151579 | 20166 | 64326982 |
Flatulence | 31.09 | 12.23 | 23 | 151561 | 35643 | 64311505 |
Device related thrombosis | 31.09 | 12.23 | 31 | 151553 | 2054 | 64345094 |
Neck pain | 30.98 | 12.23 | 61 | 151523 | 61472 | 64285676 |
Administration site extravasation | 30.64 | 12.23 | 23 | 151561 | 1036 | 64346112 |
Adverse drug reaction | 30.63 | 12.23 | 37 | 151547 | 45427 | 64301721 |
Endocarditis noninfective | 30.51 | 12.23 | 13 | 151571 | 189 | 64346959 |
Hypervolaemia | 30.49 | 12.23 | 27 | 151557 | 38258 | 64308890 |
Delirium | 30.38 | 12.23 | 74 | 151510 | 69120 | 64278028 |
Pancreatic carcinoma | 30.36 | 12.23 | 72 | 151512 | 10301 | 64336847 |
Superior vena cava syndrome | 30.33 | 12.23 | 23 | 151561 | 1052 | 64346096 |
Hypersomnia | 30.21 | 12.23 | 5 | 151579 | 19712 | 64327436 |
Joint stiffness | 30.06 | 12.23 | 17 | 151567 | 30387 | 64316761 |
Therapeutic product effect incomplete | 29.97 | 12.23 | 133 | 151451 | 103349 | 64243799 |
Periarticular thenar erythema with onycholysis | 29.92 | 12.23 | 8 | 151576 | 22 | 64347126 |
Scleroderma | 29.81 | 12.23 | 46 | 151538 | 4772 | 64342376 |
Duodenal perforation | 29.73 | 12.23 | 29 | 151555 | 1871 | 64345277 |
Right ventricular ejection fraction decreased | 29.65 | 12.23 | 9 | 151575 | 44 | 64347104 |
Right ventricular failure | 29.64 | 12.23 | 7 | 151577 | 21464 | 64325684 |
Hepatic function abnormal | 29.55 | 12.23 | 255 | 151329 | 64058 | 64283090 |
Blood pressure systolic increased | 29.50 | 12.23 | 44 | 151540 | 49409 | 64297739 |
Enterocolitis | 29.49 | 12.23 | 78 | 151506 | 11940 | 64335208 |
Hypoalbuminaemia | 29.41 | 12.23 | 100 | 151484 | 17574 | 64329574 |
Tumour pain | 29.30 | 12.23 | 29 | 151555 | 1904 | 64345244 |
Seizure | 29.25 | 12.23 | 251 | 151333 | 166641 | 64180507 |
Metastases to eye | 29.10 | 12.23 | 13 | 151571 | 213 | 64346935 |
Febrile infection | 29.07 | 12.23 | 35 | 151549 | 2866 | 64344282 |
Small intestinal obstruction | 28.94 | 12.23 | 121 | 151463 | 23452 | 64323696 |
Upper respiratory tract infection | 28.79 | 12.23 | 82 | 151502 | 72703 | 64274445 |
Amnesia | 28.74 | 12.23 | 43 | 151541 | 48226 | 64298922 |
Therapy interrupted | 28.73 | 12.23 | 6 | 151578 | 20030 | 64327118 |
Musculoskeletal disorder | 28.67 | 12.23 | 4 | 151580 | 17902 | 64329246 |
Urinary tract obstruction | 28.65 | 12.23 | 41 | 151543 | 3976 | 64343172 |
Oligohydramnios | 28.58 | 12.23 | 36 | 151548 | 3088 | 64344060 |
Death | 28.51 | 12.23 | 1397 | 150187 | 481308 | 63865840 |
Metastases to pelvis | 28.44 | 12.23 | 17 | 151567 | 521 | 64346627 |
Subclavian vein thrombosis | 28.40 | 12.23 | 31 | 151553 | 2283 | 64344865 |
Lymphadenopathy mediastinal | 28.30 | 12.23 | 40 | 151544 | 3836 | 64343312 |
Ovarian failure | 28.24 | 12.23 | 17 | 151567 | 528 | 64346620 |
Retroperitoneal lymphadenopathy | 28.22 | 12.23 | 21 | 151563 | 933 | 64346215 |
Immune-mediated enterocolitis | 28.20 | 12.23 | 33 | 151551 | 2623 | 64344525 |
Peritonitis | 28.08 | 12.23 | 125 | 151459 | 24898 | 64322250 |
Gait inability | 27.99 | 12.23 | 35 | 151549 | 42333 | 64304815 |
Transaminases increased | 27.87 | 12.23 | 190 | 151394 | 44404 | 64302744 |
Adrenocorticotropic hormone deficiency | 27.86 | 12.23 | 20 | 151564 | 840 | 64346308 |
Cerebrovascular accident | 27.80 | 12.23 | 199 | 151385 | 137384 | 64209764 |
Incorrect route of product administration | 27.76 | 12.23 | 10 | 151574 | 23288 | 64323860 |
Mood swings | 27.74 | 12.23 | 4 | 151580 | 17464 | 64329684 |
Ventricular tachycardia | 27.49 | 12.23 | 24 | 151560 | 34241 | 64312907 |
Heart rate decreased | 27.37 | 12.23 | 55 | 151529 | 55012 | 64292136 |
Balance disorder | 27.35 | 12.23 | 103 | 151481 | 83823 | 64263325 |
Neuromuscular toxicity | 27.35 | 12.23 | 12 | 151572 | 188 | 64346960 |
Joint range of motion decreased | 27.31 | 12.23 | 6 | 151578 | 19337 | 64327811 |
Liver function test abnormal | 27.30 | 12.23 | 62 | 151522 | 59339 | 64287809 |
Accidental exposure to product | 27.14 | 12.23 | 14 | 151570 | 26350 | 64320798 |
Limb discomfort | 27.14 | 12.23 | 15 | 151569 | 27160 | 64319988 |
Venous thrombosis limb | 27.13 | 12.23 | 39 | 151545 | 3798 | 64343350 |
Deep vein thrombosis | 26.88 | 12.23 | 371 | 151213 | 104811 | 64242337 |
Vocal cord paralysis | 26.77 | 12.23 | 29 | 151555 | 2117 | 64345031 |
Folliculitis | 26.73 | 12.23 | 19 | 151565 | 30058 | 64317090 |
Panic attack | 26.71 | 12.23 | 8 | 151576 | 20945 | 64326203 |
Hyperpyrexia | 26.67 | 12.23 | 45 | 151539 | 5032 | 64342116 |
Eosinophil percentage increased | 26.63 | 12.23 | 24 | 151560 | 1400 | 64345748 |
Pregnancy | 26.54 | 12.23 | 8 | 151576 | 20857 | 64326291 |
Blood potassium increased | 26.45 | 12.23 | 14 | 151570 | 25966 | 64321182 |
Abortion spontaneous | 26.41 | 12.23 | 13 | 151571 | 25130 | 64322018 |
Cardiac cirrhosis | 26.25 | 12.23 | 12 | 151572 | 208 | 64346940 |
Hypomagnesaemia | 26.25 | 12.23 | 164 | 151420 | 37212 | 64309936 |
Dermatitis acneiform | 26.24 | 12.23 | 60 | 151524 | 8383 | 64338765 |
Dysphagia | 26.19 | 12.23 | 374 | 151210 | 106438 | 64240710 |
Hepatic lesion | 25.92 | 12.23 | 48 | 151536 | 5776 | 64341372 |
Disease recurrence | 25.83 | 12.23 | 144 | 151440 | 31366 | 64315782 |
Hepatic infection | 25.74 | 12.23 | 19 | 151565 | 834 | 64346314 |
Aplasia | 25.71 | 12.23 | 53 | 151531 | 6900 | 64340248 |
Metastases to bladder | 25.69 | 12.23 | 12 | 151572 | 219 | 64346929 |
Diabetes mellitus inadequate control | 25.66 | 12.23 | 9 | 151575 | 21312 | 64325836 |
Hepatotoxicity | 25.41 | 12.23 | 171 | 151413 | 39791 | 64307357 |
Weight decreased | 25.36 | 12.23 | 496 | 151088 | 285243 | 64061905 |
Sleep disorder | 25.32 | 12.23 | 65 | 151519 | 59644 | 64287504 |
Enteritis | 25.30 | 12.23 | 74 | 151510 | 12003 | 64335145 |
Thyroid dermatopathy | 25.26 | 12.23 | 7 | 151577 | 23 | 64347125 |
Gastric perforation | 25.19 | 12.23 | 36 | 151548 | 3487 | 64343661 |
Xerophthalmia | 25.06 | 12.23 | 15 | 151569 | 461 | 64346687 |
Metastases to chest wall | 25.05 | 12.23 | 14 | 151570 | 377 | 64346771 |
Metastases to breast | 25.02 | 12.23 | 12 | 151572 | 233 | 64346915 |
Pulse absent | 25.01 | 12.23 | 61 | 151523 | 8885 | 64338263 |
Respiratory tract congestion | 24.99 | 12.23 | 4 | 151580 | 16161 | 64330987 |
Duodenitis haemorrhagic | 24.97 | 12.23 | 10 | 151574 | 123 | 64347025 |
Pulmonary tumour thrombotic microangiopathy | 24.97 | 12.23 | 9 | 151575 | 81 | 64347067 |
Dysarthria | 24.94 | 12.23 | 65 | 151519 | 59341 | 64287807 |
Tooth erosion | 24.92 | 12.23 | 14 | 151570 | 381 | 64346767 |
Gastritis bacterial | 24.84 | 12.23 | 13 | 151571 | 306 | 64346842 |
Hypopituitarism | 24.77 | 12.23 | 31 | 151553 | 2642 | 64344506 |
Anaemia of malignant disease | 24.75 | 12.23 | 17 | 151567 | 665 | 64346483 |
Sopor | 24.75 | 12.23 | 20 | 151564 | 29641 | 64317507 |
Drug ineffective for unapproved indication | 24.74 | 12.23 | 22 | 151562 | 31111 | 64316037 |
Oesophagopleural fistula | 24.72 | 12.23 | 8 | 151576 | 50 | 64347098 |
Muscle twitching | 24.68 | 12.23 | 7 | 151577 | 18991 | 64328157 |
Tumour embolism | 24.68 | 12.23 | 10 | 151574 | 127 | 64347021 |
Vena cava thrombosis | 24.67 | 12.23 | 30 | 151554 | 2482 | 64344666 |
Gallbladder disorder | 24.63 | 12.23 | 5 | 151579 | 17025 | 64330123 |
Septic shock | 24.59 | 12.23 | 366 | 151218 | 105071 | 64242077 |
Gastrointestinal haemorrhage | 24.54 | 12.23 | 196 | 151388 | 132116 | 64215032 |
Haemoglobin | 24.49 | 12.23 | 9 | 151575 | 86 | 64347062 |
Eye disorder | 24.43 | 12.23 | 7 | 151577 | 18862 | 64328286 |
Laryngeal necrosis | 24.39 | 12.23 | 7 | 151577 | 27 | 64347121 |
Lymphopenia | 24.29 | 12.23 | 122 | 151462 | 25535 | 64321613 |
Kidney infection | 24.26 | 12.23 | 6 | 151578 | 17832 | 64329316 |
Tumour pseudoprogression | 24.18 | 12.23 | 15 | 151569 | 492 | 64346656 |
Intestinal metastasis | 24.12 | 12.23 | 12 | 151572 | 253 | 64346895 |
Chronic obstructive pulmonary disease | 23.94 | 12.23 | 86 | 151498 | 70962 | 64276186 |
Tracheo-oesophageal fistula | 23.81 | 12.23 | 15 | 151569 | 506 | 64346642 |
Sinus bradycardia | 23.80 | 12.23 | 12 | 151572 | 22881 | 64324267 |
Prescribed overdose | 23.76 | 12.23 | 9 | 151575 | 20322 | 64326826 |
Breast cancer | 23.76 | 12.23 | 133 | 151451 | 29015 | 64318133 |
Device dislocation | 23.73 | 12.23 | 10 | 151574 | 21168 | 64325980 |
Viral infection | 23.73 | 12.23 | 30 | 151554 | 36110 | 64311038 |
Melaena | 23.72 | 12.23 | 57 | 151527 | 53491 | 64293657 |
Mastitis | 23.67 | 12.23 | 26 | 151558 | 1928 | 64345220 |
Type 2 diabetes mellitus | 23.65 | 12.23 | 27 | 151557 | 33993 | 64313155 |
Procedural pain | 23.61 | 12.23 | 4 | 151580 | 15504 | 64331644 |
Neoplasm recurrence | 23.56 | 12.23 | 36 | 151548 | 3703 | 64343445 |
Therapy cessation | 23.45 | 12.23 | 25 | 151559 | 32464 | 64314684 |
Computerised tomogram thorax | 23.43 | 12.23 | 10 | 151574 | 146 | 64347002 |
Immune-mediated hepatic disorder | 23.32 | 12.23 | 15 | 151569 | 525 | 64346623 |
Paranoia | 23.24 | 12.23 | 5 | 151579 | 16347 | 64330801 |
Foot fracture | 23.02 | 12.23 | 7 | 151577 | 18150 | 64328998 |
Pyogenic granuloma | 22.97 | 12.23 | 14 | 151570 | 445 | 64346703 |
Intestinal obstruction | 22.91 | 12.23 | 155 | 151429 | 36131 | 64311017 |
Speech disorder | 22.72 | 12.23 | 50 | 151534 | 48391 | 64298757 |
Spinal stenosis | 22.57 | 12.23 | 3 | 151581 | 13928 | 64333220 |
Mood altered | 22.48 | 12.23 | 5 | 151579 | 15974 | 64331174 |
Tumour associated fever | 22.36 | 12.23 | 15 | 151569 | 564 | 64346584 |
Metastases to soft tissue | 22.33 | 12.23 | 13 | 151571 | 379 | 64346769 |
Teratoma benign | 22.10 | 12.23 | 8 | 151576 | 73 | 64347075 |
Anhedonia | 22.09 | 12.23 | 3 | 151581 | 13703 | 64333445 |
Urinary retention | 22.09 | 12.23 | 52 | 151532 | 49149 | 64297999 |
Taste disorder | 21.91 | 12.23 | 60 | 151524 | 9373 | 64337775 |
Chromaturia | 21.84 | 12.23 | 13 | 151571 | 22598 | 64324550 |
Metastases to abdominal cavity | 21.84 | 12.23 | 14 | 151570 | 487 | 64346661 |
Gelastic seizure | 21.82 | 12.23 | 5 | 151579 | 5 | 64347143 |
Bone marrow infiltration | 21.81 | 12.23 | 14 | 151570 | 488 | 64346660 |
No adverse event | 21.73 | 12.23 | 21 | 151563 | 28540 | 64318608 |
Pulmonary cavitation | 21.67 | 12.23 | 21 | 151563 | 1344 | 64345804 |
Status epilepticus | 21.58 | 12.23 | 12 | 151572 | 21651 | 64325497 |
Nasal septum perforation | 21.48 | 12.23 | 16 | 151568 | 712 | 64346436 |
Vessel puncture site bruise | 21.39 | 12.23 | 13 | 151571 | 411 | 64346737 |
Sinus congestion | 21.38 | 12.23 | 5 | 151579 | 15434 | 64331714 |
Glaucoma | 21.28 | 12.23 | 6 | 151578 | 16342 | 64330806 |
Eye swelling | 21.26 | 12.23 | 13 | 151571 | 22268 | 64324880 |
Bursitis | 21.26 | 12.23 | 12 | 151572 | 21473 | 64325675 |
Renal failure | 21.15 | 12.23 | 300 | 151284 | 181388 | 64165760 |
Obesity | 21.05 | 12.23 | 11 | 151573 | 20551 | 64326597 |
Rash papular | 20.98 | 12.23 | 7 | 151577 | 17106 | 64330042 |
Transfusion | 20.97 | 12.23 | 8 | 151576 | 17986 | 64329162 |
Fungal infection | 20.89 | 12.23 | 30 | 151554 | 34221 | 64312927 |
Wound dehiscence | 20.81 | 12.23 | 44 | 151540 | 5830 | 64341318 |
Movement disorder | 20.76 | 12.23 | 13 | 151571 | 21987 | 64325161 |
Adenocarcinoma | 20.74 | 12.23 | 32 | 151552 | 3319 | 64343829 |
Periodontitis | 20.71 | 12.23 | 36 | 151548 | 4123 | 64343025 |
Pneumatosis intestinalis | 20.69 | 12.23 | 41 | 151543 | 5188 | 64341960 |
Faeces discoloured | 20.66 | 12.23 | 18 | 151566 | 25711 | 64321437 |
Hallucination, auditory | 20.65 | 12.23 | 7 | 151577 | 16932 | 64330216 |
Night sweats | 20.61 | 12.23 | 33 | 151551 | 36013 | 64311135 |
Taeniasis | 20.59 | 12.23 | 7 | 151577 | 52 | 64347096 |
Sinus disorder | 20.59 | 12.23 | 7 | 151577 | 16901 | 64330247 |
Scintillating scotoma | 20.58 | 12.23 | 10 | 151574 | 200 | 64346948 |
Hallucination, visual | 20.56 | 12.23 | 21 | 151563 | 27813 | 64319335 |
Dermatomyositis | 20.55 | 12.23 | 29 | 151555 | 2777 | 64344371 |
Double hit lymphoma | 20.54 | 12.23 | 6 | 151578 | 25 | 64347123 |
Device issue | 20.54 | 12.23 | 14 | 151570 | 22634 | 64324514 |
Invasive ductal breast carcinoma | 20.52 | 12.23 | 40 | 151544 | 5002 | 64342146 |
Orthostatic hypotension | 20.50 | 12.23 | 50 | 151534 | 46688 | 64300460 |
Depressed level of consciousness | 20.49 | 12.23 | 110 | 151474 | 81326 | 64265822 |
Device malfunction | 20.29 | 12.23 | 8 | 151576 | 17625 | 64329523 |
Splenic artery thrombosis | 20.14 | 12.23 | 7 | 151577 | 56 | 64347092 |
Cytokine release syndrome | 20.09 | 12.23 | 12 | 151572 | 20817 | 64326331 |
Nail avulsion | 20.00 | 12.23 | 8 | 151576 | 98 | 64347050 |
Localised infection | 19.84 | 12.23 | 25 | 151559 | 30136 | 64317012 |
Respiratory depth decreased | 19.82 | 12.23 | 6 | 151578 | 29 | 64347119 |
Progressive multifocal leukoencephalopathy | 19.81 | 12.23 | 9 | 151575 | 18223 | 64328925 |
Foot deformity | 19.81 | 12.23 | 7 | 151577 | 16497 | 64330651 |
Emphysematous cystitis | 19.80 | 12.23 | 10 | 151574 | 218 | 64346930 |
Dyspnoea at rest | 19.69 | 12.23 | 45 | 151539 | 6284 | 64340864 |
Product supply issue | 19.64 | 12.23 | 20 | 151564 | 1359 | 64345789 |
Underdose | 19.64 | 12.23 | 19 | 151565 | 25810 | 64321338 |
Poor quality sleep | 19.61 | 12.23 | 10 | 151574 | 18941 | 64328207 |
Hypermetabolism | 19.49 | 12.23 | 11 | 151573 | 302 | 64346846 |
Upper gastrointestinal perforation | 19.49 | 12.23 | 5 | 151579 | 11 | 64347137 |
Inflammation | 19.47 | 12.23 | 83 | 151501 | 65217 | 64281931 |
Post thrombotic syndrome | 19.42 | 12.23 | 14 | 151570 | 592 | 64346556 |
Lymphatic disorder | 19.39 | 12.23 | 11 | 151573 | 305 | 64346843 |
Bronchopleural fistula | 19.34 | 12.23 | 14 | 151570 | 596 | 64346552 |
Pulmonary artery stenosis | 19.31 | 12.23 | 8 | 151576 | 108 | 64347040 |
Osteolysis | 19.11 | 12.23 | 28 | 151556 | 2775 | 64344373 |
Therapeutic response unexpected | 19.09 | 12.23 | 8 | 151576 | 16993 | 64330155 |
Gene mutation | 19.06 | 12.23 | 24 | 151560 | 2058 | 64345090 |
Immediate post-injection reaction | 18.95 | 12.23 | 11 | 151573 | 319 | 64346829 |
Cholelithiasis | 18.94 | 12.23 | 50 | 151534 | 45456 | 64301692 |
Radiation necrosis | 18.89 | 12.23 | 11 | 151573 | 321 | 64346827 |
Glycosylated haemoglobin increased | 18.87 | 12.23 | 7 | 151577 | 16012 | 64331136 |
Pulmonary congestion | 18.82 | 12.23 | 17 | 151567 | 23863 | 64323285 |
Keratitis | 18.77 | 12.23 | 30 | 151554 | 3207 | 64343941 |
Tongue disorder | 18.65 | 12.23 | 3 | 151581 | 12077 | 64335071 |
Uterine atrophy | 18.64 | 12.23 | 5 | 151579 | 14 | 64347134 |
Angiodermatitis | 18.59 | 12.23 | 7 | 151577 | 72 | 64347076 |
Blood urine present | 18.50 | 12.23 | 10 | 151574 | 18330 | 64328818 |
Muscle rigidity | 18.41 | 12.23 | 9 | 151575 | 17464 | 64329684 |
Bronchopulmonary aspergillosis | 18.40 | 12.23 | 11 | 151573 | 19074 | 64328074 |
Hypocalcaemia | 18.37 | 12.23 | 164 | 151420 | 41589 | 64305559 |
Venous thrombosis | 18.36 | 12.23 | 44 | 151540 | 6337 | 64340811 |
Adverse event | 18.32 | 12.23 | 41 | 151543 | 39448 | 64307700 |
Transaminases | 18.26 | 12.23 | 7 | 151577 | 76 | 64347072 |
Tumour ulceration | 18.26 | 12.23 | 9 | 151575 | 186 | 64346962 |
Pancreatitis | 18.24 | 12.23 | 75 | 151509 | 59532 | 64287616 |
Gastroenteritis radiation | 18.24 | 12.23 | 14 | 151570 | 652 | 64346496 |
Ovarian cancer | 18.21 | 12.23 | 30 | 151554 | 3289 | 64343859 |
Gastroenteritis viral | 18.15 | 12.23 | 12 | 151572 | 19717 | 64327431 |
Pneumonitis chemical | 18.15 | 12.23 | 11 | 151573 | 346 | 64346802 |
Brachiocephalic vein thrombosis | 18.08 | 12.23 | 8 | 151576 | 128 | 64347020 |
Blood creatinine increased | 18.08 | 12.23 | 218 | 151366 | 135564 | 64211584 |
Erythema multiforme | 18.04 | 12.23 | 79 | 151505 | 15622 | 64331526 |
Hypophysitis | 17.98 | 12.23 | 31 | 151553 | 3528 | 64343620 |
Disturbance in attention | 17.97 | 12.23 | 44 | 151540 | 41030 | 64306118 |
Dermatitis | 17.97 | 12.23 | 87 | 151497 | 17942 | 64329206 |
Cough | 17.91 | 12.23 | 875 | 150709 | 301273 | 64045875 |
Ocular hyperaemia | 17.86 | 12.23 | 16 | 151568 | 22548 | 64324600 |
Fistula | 17.82 | 12.23 | 57 | 151527 | 9704 | 64337444 |
Eye pruritus | 17.73 | 12.23 | 4 | 151580 | 12655 | 64334493 |
Chest pain | 17.65 | 12.23 | 700 | 150884 | 235280 | 64111868 |
Oesophageal stenosis | 17.57 | 12.23 | 32 | 151552 | 3802 | 64343346 |
Cardiac murmur | 17.57 | 12.23 | 3 | 151581 | 11560 | 64335588 |
Pain in jaw | 17.56 | 12.23 | 44 | 151540 | 40711 | 64306437 |
Carbohydrate antigen 19-9 increased | 17.54 | 12.23 | 11 | 151573 | 368 | 64346780 |
Vulvovaginal inflammation | 17.50 | 12.23 | 12 | 151572 | 468 | 64346680 |
Maternal death affecting foetus | 17.46 | 12.23 | 4 | 151580 | 4 | 64347144 |
Epstein-Barr virus infection | 17.38 | 12.23 | 4 | 151580 | 12484 | 64334664 |
Liver scan abnormal | 17.37 | 12.23 | 6 | 151578 | 47 | 64347101 |
Diabetic ketoacidosis | 17.37 | 12.23 | 27 | 151557 | 29818 | 64317330 |
Joint dislocation | 17.36 | 12.23 | 3 | 151581 | 11462 | 64335686 |
Immune reconstitution inflammatory syndrome | 17.34 | 12.23 | 4 | 151580 | 12466 | 64334682 |
Dementia | 17.33 | 12.23 | 14 | 151570 | 20752 | 64326396 |
Empyema | 17.32 | 12.23 | 31 | 151553 | 3634 | 64343514 |
Exostosis | 17.31 | 12.23 | 3 | 151581 | 11435 | 64335713 |
Product quality issue | 17.31 | 12.23 | 27 | 151557 | 29772 | 64317376 |
Scar | 17.29 | 12.23 | 5 | 151579 | 13393 | 64333755 |
Ovarian cancer metastatic | 17.28 | 12.23 | 12 | 151572 | 478 | 64346670 |
Adrenal insufficiency | 17.27 | 12.23 | 101 | 151483 | 22386 | 64324762 |
Infectious pleural effusion | 17.25 | 12.23 | 27 | 151557 | 2835 | 64344313 |
Gastrointestinal necrosis | 17.23 | 12.23 | 37 | 151547 | 4955 | 64342193 |
Acute respiratory distress syndrome | 17.17 | 12.23 | 153 | 151431 | 38782 | 64308366 |
Thrombophlebitis migrans | 17.07 | 12.23 | 10 | 151574 | 295 | 64346853 |
Infected lymphocele | 17.00 | 12.23 | 9 | 151575 | 217 | 64346931 |
Breast ulceration | 16.95 | 12.23 | 6 | 151578 | 51 | 64347097 |
Haematoma | 16.93 | 12.23 | 54 | 151530 | 46196 | 64300952 |
Carpal tunnel syndrome | 16.91 | 12.23 | 8 | 151576 | 15820 | 64331328 |
Apathy | 16.88 | 12.23 | 3 | 151581 | 11229 | 64335919 |
Hepatic vein thrombosis | 16.85 | 12.23 | 9 | 151575 | 221 | 64346927 |
Immune-mediated renal disorder | 16.84 | 12.23 | 6 | 151578 | 52 | 64347096 |
Pulmonary vein stenosis | 16.84 | 12.23 | 8 | 151576 | 152 | 64346996 |
Torsade de pointes | 16.75 | 12.23 | 10 | 151574 | 17353 | 64329795 |
Pulmonary hypoplasia | 16.74 | 12.23 | 6 | 151578 | 53 | 64347095 |
Plethoric face | 16.72 | 12.23 | 5 | 151579 | 23 | 64347125 |
Hormone receptor positive breast cancer | 16.69 | 12.23 | 10 | 151574 | 308 | 64346840 |
Lung abscess | 16.64 | 12.23 | 30 | 151554 | 3536 | 64343612 |
Photophobia | 16.62 | 12.23 | 10 | 151574 | 17283 | 64329865 |
Dysstasia | 16.60 | 12.23 | 18 | 151566 | 23197 | 64323951 |
Immune-mediated dermatitis | 16.60 | 12.23 | 8 | 151576 | 157 | 64346991 |
Malignant peritoneal neoplasm | 16.56 | 12.23 | 13 | 151571 | 626 | 64346522 |
Laryngeal cancer stage III | 16.55 | 12.23 | 5 | 151579 | 24 | 64347124 |
Blood glucose decreased | 16.46 | 12.23 | 18 | 151566 | 23105 | 64324043 |
Hypothalamo-pituitary disorder | 16.46 | 12.23 | 16 | 151568 | 1028 | 64346120 |
Lymphadenopathy | 16.43 | 12.23 | 175 | 151409 | 46511 | 64300637 |
Depressed mood | 16.37 | 12.23 | 46 | 151538 | 40966 | 64306182 |
Arteriosclerosis coronary artery | 16.36 | 12.23 | 8 | 151576 | 15521 | 64331627 |
Sputum discoloured | 16.24 | 12.23 | 11 | 151573 | 17845 | 64329303 |
Vaginal cuff dehiscence | 16.19 | 12.23 | 4 | 151580 | 7 | 64347141 |
Onychalgia | 16.03 | 12.23 | 14 | 151570 | 783 | 64346365 |
Hip arthroplasty | 15.90 | 12.23 | 16 | 151568 | 21335 | 64325813 |
Congestive cardiomyopathy | 15.89 | 12.23 | 57 | 151527 | 10287 | 64336861 |
Atrioventricular block first degree | 15.84 | 12.23 | 3 | 151581 | 10731 | 64336417 |
Metastases to ovary | 15.76 | 12.23 | 9 | 151575 | 253 | 64346895 |
Pruritus | 15.70 | 12.23 | 588 | 150996 | 311812 | 64035336 |
Joint effusion | 15.69 | 12.23 | 6 | 151578 | 13467 | 64333681 |
Cystitis noninfective | 15.68 | 12.23 | 16 | 151568 | 1090 | 64346058 |
Cholangitis infective | 15.62 | 12.23 | 11 | 151573 | 448 | 64346700 |
Pneumoperitoneum | 15.55 | 12.23 | 25 | 151559 | 2686 | 64344462 |
Blood creatinine decreased | 15.55 | 12.23 | 44 | 151540 | 7006 | 64340142 |
Intestinal ischaemia | 15.54 | 12.23 | 61 | 151523 | 11488 | 64335660 |
Drug resistance | 15.51 | 12.23 | 138 | 151446 | 34964 | 64312184 |
Campylobacter test positive | 15.50 | 12.23 | 6 | 151578 | 67 | 64347081 |
Median nerve injury | 15.48 | 12.23 | 5 | 151579 | 31 | 64347117 |
Haematochezia | 15.43 | 12.23 | 92 | 151492 | 66281 | 64280867 |
Obstruction gastric | 15.41 | 12.23 | 18 | 151566 | 1428 | 64345720 |
Swelling face | 15.40 | 12.23 | 79 | 151505 | 59087 | 64288061 |
Product storage error | 15.39 | 12.23 | 6 | 151578 | 13312 | 64333836 |
Arrhythmia | 15.35 | 12.23 | 68 | 151516 | 52876 | 64294272 |
Tidal volume decreased | 15.34 | 12.23 | 6 | 151578 | 69 | 64347079 |
Blast cells present | 15.31 | 12.23 | 14 | 151570 | 832 | 64346316 |
Pancreatic failure | 15.27 | 12.23 | 18 | 151566 | 1442 | 64345706 |
Blood magnesium decreased | 15.25 | 12.23 | 69 | 151515 | 13836 | 64333312 |
Guillain-Barre syndrome | 15.25 | 12.23 | 46 | 151538 | 7589 | 64339559 |
Colitis ulcerative | 15.24 | 12.23 | 19 | 151565 | 23009 | 64324139 |
Infusion site hypersensitivity | 15.24 | 12.23 | 4 | 151580 | 10 | 64347138 |
Adenocarcinoma of appendix | 15.19 | 12.23 | 6 | 151578 | 71 | 64347077 |
Hypophagia | 15.18 | 12.23 | 151 | 151433 | 39436 | 64307712 |
Radiation pericarditis | 15.17 | 12.23 | 3 | 151581 | 0 | 64347148 |
Ankyloglossia acquired | 15.17 | 12.23 | 3 | 151581 | 0 | 64347148 |
Ecchymosis | 15.11 | 12.23 | 7 | 151577 | 14015 | 64333133 |
Portal vein thrombosis | 14.99 | 12.23 | 35 | 151549 | 4956 | 64342192 |
Lymphoma | 14.96 | 12.23 | 7 | 151577 | 13934 | 64333214 |
Arterioenteric fistula | 14.96 | 12.23 | 4 | 151580 | 11 | 64347137 |
Biliary obstruction | 14.93 | 12.23 | 30 | 151554 | 3834 | 64343314 |
Mania | 14.86 | 12.23 | 10 | 151574 | 16276 | 64330872 |
Meibomian gland dysfunction | 14.83 | 12.23 | 7 | 151577 | 131 | 64347017 |
Xeroderma | 14.78 | 12.23 | 8 | 151576 | 202 | 64346946 |
Immune-mediated nephritis | 14.77 | 12.23 | 9 | 151575 | 286 | 64346862 |
Malignant melanoma | 14.72 | 12.23 | 6 | 151578 | 12958 | 64334190 |
Clonal haematopoiesis | 14.71 | 12.23 | 4 | 151580 | 12 | 64347136 |
Superinfection bacterial | 14.70 | 12.23 | 16 | 151568 | 1174 | 64345974 |
Odynophagia | 14.70 | 12.23 | 53 | 151531 | 9588 | 64337560 |
Influenza like illness | 14.62 | 12.23 | 85 | 151499 | 61617 | 64285531 |
Cancer fatigue | 14.61 | 12.23 | 6 | 151578 | 79 | 64347069 |
Uterine adhesions | 14.61 | 12.23 | 5 | 151579 | 38 | 64347110 |
Hypotension | 14.55 | 12.23 | 1061 | 150523 | 379913 | 63967235 |
Fatigue | 14.51 | 12.23 | 1989 | 149595 | 746741 | 63600407 |
Pulmonary artery occlusion | 14.50 | 12.23 | 5 | 151579 | 39 | 64347109 |
Pollakiuria | 14.41 | 12.23 | 33 | 151551 | 31497 | 64315651 |
Nasal disorder | 14.41 | 12.23 | 25 | 151559 | 2859 | 64344289 |
Psychomotor hyperactivity | 14.40 | 12.23 | 8 | 151576 | 14443 | 64332705 |
Pancreatic enzyme abnormality | 14.35 | 12.23 | 6 | 151578 | 83 | 64347065 |
Peritoneal disorder | 14.28 | 12.23 | 12 | 151572 | 637 | 64346511 |
Lung infiltration | 14.26 | 12.23 | 91 | 151493 | 20798 | 64326350 |
Hernia | 14.18 | 12.23 | 7 | 151577 | 13511 | 64333637 |
Breast cellulitis | 14.17 | 12.23 | 9 | 151575 | 308 | 64346840 |
Ulcer | 14.16 | 12.23 | 20 | 151564 | 22970 | 64324178 |
Systemic toxicity | 14.16 | 12.23 | 6 | 151578 | 86 | 64347062 |
Pseudocyst | 14.14 | 12.23 | 9 | 151575 | 309 | 64346839 |
Coagulopathy | 14.12 | 12.23 | 34 | 151550 | 31886 | 64315262 |
Angiosarcoma | 14.08 | 12.23 | 10 | 151574 | 413 | 64346735 |
Toxic neuropathy | 14.07 | 12.23 | 13 | 151571 | 783 | 64346365 |
Embryonal rhabdomyosarcoma | 14.07 | 12.23 | 5 | 151579 | 43 | 64347105 |
Triple negative breast cancer | 14.03 | 12.23 | 6 | 151578 | 88 | 64347060 |
Tumour cavitation | 14.03 | 12.23 | 4 | 151580 | 15 | 64347133 |
Loss of consciousness | 14.02 | 12.23 | 452 | 151132 | 147913 | 64199235 |
Tumour hyperprogression | 13.97 | 12.23 | 7 | 151577 | 150 | 64346998 |
Renal disorder | 13.87 | 12.23 | 40 | 151544 | 35325 | 64311823 |
Hypergeusia | 13.82 | 12.23 | 4 | 151580 | 16 | 64347132 |
Laboratory test abnormal | 13.79 | 12.23 | 22 | 151562 | 24041 | 64323107 |
Post procedural fistula | 13.78 | 12.23 | 8 | 151576 | 232 | 64346916 |
Vascular pseudoaneurysm ruptured | 13.76 | 12.23 | 7 | 151577 | 155 | 64346993 |
Neoplasm | 13.71 | 12.23 | 42 | 151542 | 6989 | 64340159 |
Thinking abnormal | 13.70 | 12.23 | 5 | 151579 | 11551 | 64335597 |
Porokeratosis | 13.66 | 12.23 | 8 | 151576 | 236 | 64346912 |
Haemodialysis | 13.65 | 12.23 | 12 | 151572 | 17065 | 64330083 |
Subclavian artery occlusion | 13.64 | 12.23 | 7 | 151577 | 158 | 64346990 |
Metastases to vagina | 13.63 | 12.23 | 4 | 151580 | 17 | 64347131 |
Mucosal infection | 13.62 | 12.23 | 10 | 151574 | 435 | 64346713 |
Vision blurred | 13.60 | 12.23 | 141 | 151443 | 90175 | 64256973 |
Diverticulum | 13.60 | 12.23 | 7 | 151577 | 13191 | 64333957 |
Vaginal fistula | 13.60 | 12.23 | 8 | 151576 | 238 | 64346910 |
Dandy-Walker syndrome | 13.59 | 12.23 | 5 | 151579 | 48 | 64347100 |
Tumour perforation | 13.52 | 12.23 | 9 | 151575 | 334 | 64346814 |
Angiosarcoma metastatic | 13.50 | 12.23 | 5 | 151579 | 49 | 64347099 |
Lower gastrointestinal haemorrhage | 13.48 | 12.23 | 8 | 151576 | 13931 | 64333217 |
Obstructive airways disorder | 13.47 | 12.23 | 21 | 151563 | 23164 | 64323984 |
Ankle fracture | 13.46 | 12.23 | 9 | 151575 | 14701 | 64332447 |
Ear pain | 13.46 | 12.23 | 24 | 151560 | 25112 | 64322036 |
Aortic dissection rupture | 13.45 | 12.23 | 4 | 151580 | 18 | 64347130 |
Bladder necrosis | 13.45 | 12.23 | 4 | 151580 | 18 | 64347130 |
Coronary artery occlusion | 13.40 | 12.23 | 8 | 151576 | 13883 | 64333265 |
Immune-mediated myocarditis | 13.39 | 12.23 | 10 | 151574 | 447 | 64346701 |
Immune-mediated hypothyroidism | 13.37 | 12.23 | 7 | 151577 | 165 | 64346983 |
Discontinued product administered | 13.32 | 12.23 | 5 | 151579 | 51 | 64347097 |
Portal venous gas | 13.31 | 12.23 | 9 | 151575 | 343 | 64346805 |
Non-small cell lung cancer | 13.30 | 12.23 | 33 | 151551 | 4857 | 64342291 |
Thrombocytosis | 13.26 | 12.23 | 42 | 151542 | 7114 | 64340034 |
Tumour invasion | 13.24 | 12.23 | 9 | 151575 | 346 | 64346802 |
Chemotherapy | 13.21 | 12.23 | 17 | 151567 | 1490 | 64345658 |
Ill-defined disorder | 13.13 | 12.23 | 56 | 151528 | 43996 | 64303152 |
Abnormal dreams | 13.12 | 12.23 | 4 | 151580 | 10352 | 64336796 |
Pulpitis dental | 13.12 | 12.23 | 14 | 151570 | 1005 | 64346143 |
Glomerular filtration rate decreased | 13.11 | 12.23 | 16 | 151568 | 19556 | 64327592 |
Breast sarcoma | 13.09 | 12.23 | 3 | 151581 | 3 | 64347145 |
Ulcerated haemangioma | 13.09 | 12.23 | 3 | 151581 | 3 | 64347145 |
Breast prosthesis removal | 13.09 | 12.23 | 3 | 151581 | 3 | 64347145 |
Vaginal perforation | 13.09 | 12.23 | 3 | 151581 | 3 | 64347145 |
Musculoskeletal pain | 13.04 | 12.23 | 125 | 151459 | 81169 | 64265979 |
Renal impairment | 13.00 | 12.23 | 231 | 151353 | 134786 | 64212362 |
Metastases to adrenals | 13.00 | 12.23 | 15 | 151569 | 1174 | 64345974 |
KL-6 increased | 12.98 | 12.23 | 5 | 151579 | 55 | 64347093 |
Hereditary motor and sensory neuropathy | 12.97 | 12.23 | 6 | 151578 | 107 | 64347041 |
Generalised tonic-clonic seizure | 12.93 | 12.23 | 49 | 151535 | 39808 | 64307340 |
Blood pressure immeasurable | 12.92 | 12.23 | 19 | 151565 | 1889 | 64345259 |
Obstructive shock | 12.90 | 12.23 | 5 | 151579 | 56 | 64347092 |
Acute pulmonary oedema | 12.90 | 12.23 | 62 | 151522 | 12747 | 64334401 |
Cholecystitis chronic | 12.87 | 12.23 | 3 | 151581 | 9284 | 64337864 |
Thrombotic thrombocytopenic purpura | 12.86 | 12.23 | 37 | 151547 | 5947 | 64341201 |
Secretion discharge | 12.85 | 12.23 | 6 | 151578 | 11958 | 64335190 |
Prescribed underdose | 12.85 | 12.23 | 14 | 151570 | 18001 | 64329147 |
Metastases to uterus | 12.82 | 12.23 | 5 | 151579 | 57 | 64347091 |
Ototoxicity | 12.82 | 12.23 | 23 | 151561 | 2700 | 64344448 |
Increased tendency to bruise | 12.81 | 12.23 | 3 | 151581 | 9252 | 64337896 |
Abdominal infection | 12.79 | 12.23 | 24 | 151560 | 2916 | 64344232 |
Mediastinal fibrosis | 12.79 | 12.23 | 4 | 151580 | 22 | 64347126 |
Jugular vein thrombosis | 12.77 | 12.23 | 28 | 151556 | 3803 | 64343345 |
Non-small cell lung cancer recurrent | 12.75 | 12.23 | 5 | 151579 | 58 | 64347090 |
Eructation | 12.68 | 12.23 | 3 | 151581 | 9188 | 64337960 |
Lung squamous cell carcinoma metastatic | 12.67 | 12.23 | 5 | 151579 | 59 | 64347089 |
CSF white blood cell count decreased | 12.64 | 12.23 | 4 | 151580 | 23 | 64347125 |
Full blood count decreased | 12.61 | 12.23 | 21 | 151563 | 22561 | 64324587 |
Bladder cancer | 12.59 | 12.23 | 5 | 151579 | 10969 | 64336179 |
Duodenal obstruction | 12.50 | 12.23 | 9 | 151575 | 380 | 64346768 |
Immune-mediated encephalitis | 12.49 | 12.23 | 8 | 151576 | 278 | 64346870 |
Cognitive disorder | 12.46 | 12.23 | 77 | 151507 | 55010 | 64292138 |
Distal intestinal obstruction syndrome | 12.42 | 12.23 | 11 | 151573 | 627 | 64346521 |
Brain injury | 12.35 | 12.23 | 4 | 151580 | 9961 | 64337187 |
Vitamin D deficiency | 12.35 | 12.23 | 6 | 151578 | 11686 | 64335462 |
Acquired gene mutation | 12.34 | 12.23 | 19 | 151565 | 1967 | 64345181 |
Transient psychosis | 12.31 | 12.23 | 5 | 151579 | 64 | 64347084 |
Steatorrhoea | 12.30 | 12.23 | 12 | 151572 | 774 | 64346374 |
Haemolytic anaemia | 12.26 | 12.23 | 72 | 151512 | 15981 | 64331167 |
Bacterial diarrhoea | 12.26 | 12.23 | 6 | 151578 | 122 | 64347026 |
Radiation dysphagia | 12.24 | 12.23 | 3 | 151581 | 5 | 64347143 |
Stent malfunction | 12.24 | 12.23 | 5 | 151579 | 65 | 64347083 |
None
Source | Code | Description |
---|---|---|
ATC | L01CD01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Taxanes |
FDA PE | N0000175085 | Microtubule Inhibition |
FDA EPC | N0000175592 | Microtubule Inhibitor |
MeSH PA | D000970 | Antineoplastic Agents |
CHEBI has role | CHEBI:25212 | metabolites |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:61950 | microtubule stabilizing role |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D050257 | Tubulin Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ocular hypertension | indication | 4210003 | DOID:9282 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Secondary malignant neoplasm of pancreas | indication | 94459006 | |
Kaposi's sarcoma | indication | 109385007 | |
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Carcinoma of breast | indication | 254838004 | DOID:3459 |
Carcinoma of fallopian tube | indication | 276870001 | DOID:1963 |
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Malignant tumor of peritoneum | indication | 363492001 | |
Metastatic Breast Carcinoma | indication | ||
Malignant glaucoma | off-label use | 10100008 | |
Aphakic glaucoma | off-label use | 15374009 | |
Secondary glaucoma | off-label use | 95717004 | |
Neoplasm of esophagus | off-label use | 126817006 | DOID:5041 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Endometrial carcinoma | off-label use | 254878006 | DOID:2871 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Malignant tumor of cervix | off-label use | 363354003 | DOID:4362 |
Malignant tumor of testis | off-label use | 363449006 | DOID:2998 |
Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
Bronchospasm | contraindication | 4386001 | |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Complete atrioventricular block | contraindication | 27885002 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Depressive disorder | contraindication | 35489007 | |
Anaphylaxis | contraindication | 39579001 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Acute infectious disease | contraindication | 63171007 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Pulmonary emphysema | contraindication | 87433001 | |
Cardiogenic shock | contraindication | 89138009 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Liver function tests abnormal | contraindication | 166603001 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Pheochromocytoma | contraindication | 302835009 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Acute exacerbation of asthma | contraindication | 708038006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.47 | acidic |
pKa2 | 12.08 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8314156 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8314156 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7758891 | Feb. 21, 2026 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8268348 | Feb. 21, 2026 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9101543 | Feb. 21, 2026 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8034375 | Aug. 13, 2026 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9393318 | March 4, 2032 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9597409 | March 4, 2032 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9511046 | Jan. 12, 2034 | TREATMENT OF PANCREATIC CANCER |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | Dec. 6, 2022 | ADDITIONAL CLINICAL TRIAL INFORMATION ADDED TO PEDIATRIC USE SUBSECTION |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | June 6, 2023 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | EC50 | 8.05 | IUPHAR | SCIENTIFIC LITERATURE | |||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | AGONIST | EC50 | 5.30 | IUPHAR | ||||
Delta-type opioid receptor | GPCR | Ki | 5.83 | DRUG MATRIX | |||||
Bile salt export pump | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Tubulin beta chain | Structural | INHIBITOR | EC50 | 8.05 | IUPHAR | ||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 4.62 | DRUG MATRIX | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 4.95 | DRUG MATRIX | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 5.59 | CHEMBL | |||||
Substance-K receptor | GPCR | Ki | 5.69 | DRUG MATRIX | |||||
Melanocortin receptor 5 | GPCR | Ki | 4.79 | DRUG MATRIX | |||||
Tyrosine-protein kinase Mer | Kinase | IC50 | 5.31 | CHEMBL | |||||
Tubulin beta-3 chain | Structural | IC50 | 8.11 | CHEMBL | |||||
Nucleotide-binding oligomerization domain-containing protein 2 | Cytosolic other | IC50 | 5.10 | CHEMBL | |||||
Cholecystokinin receptor type A | GPCR | Ki | 5.64 | DRUG MATRIX | |||||
Botulinum neurotoxin type A | Enzyme | IC50 | 5.28 | CHEMBL |
ID | Source |
---|---|
4020736 | VUID |
N0000148314 | NUI |
D00491 | KEGG_DRUG |
4020736 | VANDF |
C0144576 | UMLSCUI |
CHEBI:45863 | CHEBI |
TA1 | PDB_CHEM_ID |
CHEMBL428647 | ChEMBL_ID |
D017239 | MESH_DESCRIPTOR_UI |
DB01229 | DRUGBANK_ID |
2770 | IUPHAR_LIGAND_ID |
7052 | INN_ID |
P88XT4IS4D | UNII |
36314 | PUBCHEM_CID |
196466 | RXNORM |
2296 | MMSL |
42243 | MMSL |
5224 | MMSL |
64289 | MMSL |
d01376 | MMSL |
004116 | NDDF |
387374002 | SNOMEDCT_US |
67735003 | SNOMEDCT_US |
D000068196 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3213 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3213 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3216 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3216 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3217 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3218 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3218 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4764 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4768 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 16714-137 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-098 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-710 | INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION | 100 mg | INTRAVENOUS | NDA authorized generic | 32 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-504 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-505 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-506 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-613 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-593 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-594 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-595 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel protein-bound particles for injectable suspension (albumin-bound) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6230 | INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION | 100 mg | INTRAVENOUS | NDA authorized generic | 32 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61703-342 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 63323-763 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-516 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
PACLITAXELPACLITAXEL | Human Prescription Drug Label | 1 | 68083-178 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 19 sections |
PACLITAXELPACLITAXEL | Human Prescription Drug Label | 1 | 68083-179 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 19 sections |
PACLITAXELPACLITAXEL | Human Prescription Drug Label | 1 | 68083-180 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 19 sections |
ABRAXANE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68817-134 | INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION | 100 mg | INTRAVENOUS | NDA | 32 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 69539-157 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 69539-158 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 69539-159 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |