paclitaxel Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, taxane derivatives 2044 33069-62-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • paclitaxel
  • (-)-Paclitaxel
  • abraxane
  • capxol
  • cyclopax
  • ebetaxel
  • genaxol
  • mitotax
  • padexol
  • plaxicel
  • taxol
  • Taxol A
  • Tocosol Paclitaxel
  • nabpaclitaxel
  • ABI-007
  • nab-paclitaxel
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
  • Molecular weight: 853.92
  • Formula: C47H51NO14
  • CLOGP: 4.73
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 4
  • TPSA: 221.29
  • ALOGS: -5.19
  • ROTB: 14

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.54 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 6.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 10, 2019 EMA TEVA BV
Sept. 20, 2019 PMDA Taiho Pharmaceutical Co., Ltd.
Dec. 29, 1992 FDA HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1444.44 12.49 1915 132697 141289 46410161
Malignant neoplasm progression 1428.67 12.49 1309 133303 63617 46487833
Neuropathy peripheral 1292.68 12.49 1447 133165 89446 46462004
Disease progression 1059.47 12.49 1310 133302 89990 46461460
Metastases to liver 956.94 12.49 634 133978 18951 46532499
Erythema 863.07 12.49 1506 133106 141314 46410136
Metastases to bone 859.28 12.49 568 134044 16908 46534542
Febrile neutropenia 841.59 12.49 1192 133420 93435 46458015
Flushing 685.26 12.49 887 133725 63727 46487723
Drug ineffective 672.05 12.49 584 134028 677254 45874196
Breast cancer metastatic 632.52 12.49 428 134184 13250 46538200
Rheumatoid arthritis 618.04 12.49 16 134596 240199 46311251
Palmar-plantar erythrodysaesthesia syndrome 577.71 12.49 476 134136 19975 46531475
Anaemia 545.13 12.49 1797 132815 253982 46297468
Neutrophil count decreased 540.17 12.49 646 133966 42780 46508670
Dyspnoea 532.06 12.49 2900 131712 512648 46038802
Metastases to lung 519.29 12.49 345 134267 10351 46541099
Peripheral sensory neuropathy 489.33 12.49 279 134333 6324 46545126
Metastases to central nervous system 462.10 12.49 327 134285 10894 46540556
Polyneuropathy 442.13 12.49 323 134289 11321 46540129
Completed suicide 389.88 12.49 6 134606 145914 46405536
Neurotoxicity 386.79 12.49 319 134293 13398 46538052
Ejection fraction decreased 386.70 12.49 358 134254 17579 46533871
Leukopenia 363.91 12.49 683 133929 67660 46483790
Fall 363.26 12.49 253 134359 328844 46222606
Neoplasm progression 361.76 12.49 415 134197 26268 46525182
Product dose omission issue 359.59 12.49 35 134577 168485 46382965
Mucosal inflammation 357.80 12.49 499 134113 38477 46512973
Acute myeloid leukaemia 348.06 12.49 319 134293 15459 46535991
Haematotoxicity 327.78 12.49 220 134392 6713 46544737
Breast cancer 326.35 12.49 519 134093 44999 46506451
Thrombocytopenia 321.22 12.49 946 133666 125635 46425815
Metastases to lymph nodes 319.71 12.49 213 134399 6418 46545032
Bone marrow failure 310.63 12.49 405 134207 29264 46522186
Pneumonitis 310.16 12.49 396 134216 28024 46523426
Ascites 307.28 12.49 449 134163 36135 46515315
Chest discomfort 303.86 12.49 749 133863 89520 46461930
Joint swelling 296.97 12.49 59 134553 166014 46385436
Headache 258.49 12.49 629 133983 477723 46073727
Death 253.96 12.49 1745 132867 333803 46217647
Proteinuria 251.02 12.49 273 134339 16280 46535170
Pseudocirrhosis 243.95 12.49 87 134525 601 46550849
Weight increased 238.56 12.49 88 134524 164385 46387065
Cystoid macular oedema 238.23 12.49 107 134505 1429 46550021
Condition aggravated 236.67 12.49 215 134397 244837 46306613
Gastrointestinal perforation 229.74 12.49 133 134479 3104 46548346
Feeling hot 229.70 12.49 401 134211 37527 46513923
Hypertension 228.81 12.49 1145 133467 195211 46356239
General physical health deterioration 228.62 12.49 794 133818 114975 46436475
Onycholysis 227.44 12.49 96 134516 1092 46550358
Pleural effusion 222.83 12.49 633 133979 82319 46469131
Myelosuppression 221.03 12.49 181 134431 7522 46543928
Anaphylactic shock 215.69 12.49 279 134333 19995 46531455
Metastases to peritoneum 212.76 12.49 118 134494 2530 46548920
Skin toxicity 209.77 12.49 131 134481 3523 46547927
Injection site pain 204.68 12.49 32 134580 107120 46444330
Sinusitis 202.89 12.49 61 134551 129707 46421743
Epistaxis 201.04 12.49 519 134093 63786 46487664
Second primary malignancy 200.11 12.49 160 134452 6424 46545026
Contraindicated product administered 192.51 12.49 9 134603 79938 46471512
Bronchospasm 190.80 12.49 231 134381 15476 46535974
Interstitial lung disease 190.32 12.49 456 134156 53493 46497957
Psoriasis 185.61 12.49 10 134602 78594 46472856
Hypersensitivity 180.96 12.49 885 133727 149436 46402014
Myelodysplastic syndrome 176.26 12.49 222 134390 15489 46535961
Ovarian cancer 170.97 12.49 138 134474 5617 46545833
Overdose 170.54 12.49 42 134570 101937 46449513
Somnolence 170.12 12.49 122 134490 156399 46395051
Drug hypersensitivity 165.01 12.49 281 134331 243544 46307906
Pyrexia 164.76 12.49 1631 132981 347171 46204279
Therapeutic product effect decreased 163.94 12.49 22 134590 82579 46468871
Drug abuse 163.66 12.49 4 134608 63404 46488046
Pain 161.17 12.49 768 133844 476180 46075270
Vomiting 158.68 12.49 1996 132616 450798 46100652
Arthropathy 155.75 12.49 28 134584 84672 46466778
Infusion related reaction 155.68 12.49 641 133971 100567 46450883
Ovarian cancer recurrent 155.43 12.49 70 134542 941 46550509
Cardiac dysfunction 152.39 12.49 78 134534 1413 46550037
Bone pain 149.16 12.49 381 134231 46509 46504941
Musculoskeletal stiffness 147.90 12.49 49 134563 97944 46453506
Back pain 147.73 12.49 1074 133538 208965 46342485
Synovitis 146.63 12.49 7 134605 61068 46490382
Toxicity to various agents 146.06 12.49 241 134371 211525 46339925
Embolism 145.23 12.49 138 134474 7000 46544450
Injection site erythema 144.93 12.49 21 134591 74406 46477044
Osteonecrosis of jaw 144.89 12.49 312 134300 34090 46517360
Suicide attempt 143.87 12.49 3 134609 55033 46496417
Abdominal discomfort 142.97 12.49 135 134477 151030 46400420
Drug interaction 141.12 12.49 230 134382 202864 46348586
Breast cancer recurrent 140.59 12.49 105 134507 3806 46547644
Nail disorder 138.93 12.49 141 134471 7755 46543695
Hospitalisation 132.90 12.49 14 134598 63371 46488079
Metastasis 131.49 12.49 105 134507 4207 46547243
Lymphangiosis carcinomatosa 131.00 12.49 65 134547 1099 46550351
Pancreatic carcinoma metastatic 129.90 12.49 83 134529 2325 46549125
Depression 129.39 12.49 181 134431 169923 46381527
Peripheral swelling 128.61 12.49 160 134452 157911 46393539
White blood cell count decreased 124.56 12.49 646 133966 111585 46439865
Influenza 124.00 12.49 51 134561 89219 46462231
Product use issue 122.18 12.49 60 134552 94584 46456866
Peripheral motor neuropathy 119.20 12.49 66 134546 1410 46550040
Systemic lupus erythematosus 118.85 12.49 22 134590 65158 46486292
Diarrhoea 117.96 12.49 2264 132348 557338 45994112
Nausea 117.32 12.49 2696 131916 684758 45866692
Abdominal pain 115.42 12.49 1090 133522 228941 46322509
Exposure during pregnancy 115.38 12.49 86 134526 108126 46443324
Platelet count decreased 114.65 12.49 581 134031 99443 46452007
Sense of oppression 113.92 12.49 57 134555 982 46550468
Dysaesthesia 113.69 12.49 85 134527 3086 46548364
Cardiotoxicity 112.76 12.49 117 134495 6605 46544845
Gastrointestinal toxicity 112.32 12.49 96 134516 4235 46547215
Nail discolouration 112.22 12.49 74 134538 2190 46549260
Treatment failure 111.38 12.49 65 134547 93022 46458428
Migraine 111.07 12.49 32 134580 69994 46481456
Stomatitis 110.89 12.49 440 134172 67857 46483593
Inappropriate schedule of product administration 110.19 12.49 26 134586 64987 46486463
Arthritis 109.29 12.49 43 134569 77273 46474177
Hypertransaminasaemia 108.64 12.49 86 134526 3402 46548048
Nasopharyngitis 107.29 12.49 174 134438 153824 46397626
Hepatic atrophy 107.06 12.49 37 134575 230 46551220
Paraesthesia 105.11 12.49 638 133974 116799 46434651
Nail toxicity 104.11 12.49 39 134573 315 46551135
Feeling abnormal 103.37 12.49 125 134487 124935 46426515
Dehydration 102.58 12.49 799 133813 158741 46392709
Asthma 102.52 12.49 69 134543 91473 46459977
Metastases to meninges 100.44 12.49 65 134547 1862 46549588
PIK3CA-activated mutation 100.05 12.49 44 134568 557 46550893
Left ventricular dysfunction 99.62 12.49 135 134477 10120 46541330
Arthralgia 99.35 12.49 630 133982 363973 46187477
Muscle spasms 98.67 12.49 126 134486 122987 46428463
Large intestine perforation 97.84 12.49 115 134497 7465 46543985
Insomnia 94.98 12.49 209 134403 164715 46386735
Ileus 94.78 12.49 156 134456 13908 46537542
Loss of personal independence in daily activities 94.70 12.49 24 134588 57159 46494291
Injection site pruritus 93.98 12.49 5 134607 39738 46511712
Drug intolerance 93.48 12.49 176 134436 146873 46404577
Urogenital fistula 93.37 12.49 28 134584 101 46551349
Abortion spontaneous 93.16 12.49 9 134603 43637 46507813
Injection site swelling 92.54 12.49 6 134606 40321 46511129
Swelling 92.16 12.49 135 134477 124376 46427074
Injection site reaction 91.99 12.49 14 134598 47835 46503615
Fibromyalgia 91.50 12.49 3 134609 36460 46514990
Hypokalaemia 91.02 12.49 497 134115 87527 46463923
Gait disturbance 90.47 12.49 176 134436 145087 46406363
Cyanosis 90.41 12.49 164 134448 15807 46535643
Plasma cell myeloma 90.28 12.49 11 134601 44467 46506983
Intentional product misuse 90.12 12.49 14 134598 47114 46504336
Tachycardia 88.98 12.49 541 134071 99081 46452369
Therapy partial responder 88.62 12.49 87 134525 4595 46546855
Memory impairment 88.34 12.49 57 134555 77280 46474170
Incorrect dose administered 88.32 12.49 13 134599 45537 46505913
Metastases to skin 88.22 12.49 53 134559 1327 46550123
Pulmonary embolism 87.88 12.49 575 134037 108010 46443440
Glossodynia 87.59 12.49 12 134600 44361 46507089
Oxygen saturation decreased 87.26 12.49 413 134199 68751 46482699
Contusion 86.40 12.49 75 134537 87412 46464038
Suicidal ideation 83.65 12.49 29 134583 56353 46495097
Mobility decreased 83.51 12.49 35 134577 60559 46490891
Blood cholesterol increased 83.46 12.49 9 134603 40004 46511446
Metastases to spine 80.87 12.49 65 134547 2629 46548821
Hydronephrosis 80.75 12.49 111 134501 8434 46543016
Laryngospasm 79.27 12.49 66 134546 2807 46548643
Small intestinal obstruction 77.86 12.49 155 134457 16017 46535433
Malignant pleural effusion 77.41 12.49 61 134551 2397 46549053
Pancreatic carcinoma 77.30 12.49 95 134517 6462 46544988
Biliary tract infection 76.83 12.49 33 134579 393 46551057
Intestinal perforation 76.70 12.49 123 134489 10728 46540722
Acute promyelocytic leukaemia 76.62 12.49 42 134570 879 46550571
Disease recurrence 76.02 12.49 166 134446 18305 46533145
Pneumocystis jirovecii pneumonia 75.65 12.49 148 134464 15100 46536350
Decreased appetite 75.60 12.49 873 133739 192963 46358487
Tumour necrosis 74.76 12.49 39 134573 736 46550714
Cholangitis 74.20 12.49 79 134533 4595 46546855
Hepatic failure 73.64 12.49 238 134374 33178 46518272
Asthenia 71.98 12.49 1278 133334 309797 46241653
Metastases to the mediastinum 70.73 12.49 32 134580 435 46551015
Hypoxia 70.15 12.49 316 134296 51522 46499928
Therapeutic product effect incomplete 70.15 12.49 73 134539 78080 46473370
Bronchitis 68.96 12.49 125 134487 105854 46445596
Subileus 68.72 12.49 62 134550 2941 46548509
Cardiomyopathy 67.92 12.49 146 134466 15927 46535523
Chronic obstructive pulmonary disease 67.86 12.49 41 134571 57592 46493858
Hypoglycaemia 67.81 12.49 36 134576 54313 46497137
Osteoarthritis 66.46 12.49 49 134563 61976 46489474
Fluid retention 66.40 12.49 32 134580 51014 46500436
Throat tightness 64.87 12.49 167 134445 20472 46530978
Anxiety 64.73 12.49 287 134325 181670 46369780
Pain in extremity 63.84 12.49 460 134152 258220 46293230
Injury 63.01 12.49 24 134588 44003 46507447
Neutropenic sepsis 61.60 12.49 120 134492 12204 46539246
Carbohydrate antigen 15-3 increased 60.40 12.49 36 134576 888 46550562
Unevaluable event 59.98 12.49 29 134583 46146 46505304
Hallucination 59.56 12.49 35 134577 49916 46501534
Metastases to retroperitoneum 59.14 12.49 21 134591 143 46551307
Portal hypertension 59.10 12.49 61 134551 3422 46548028
Posterior reversible encephalopathy syndrome 58.85 12.49 133 134479 15008 46536442
Drug reaction with eosinophilia and systemic symptoms 58.30 12.49 8 134604 29540 46521910
Fistula 58.27 12.49 92 134520 7918 46543532
Maternal exposure during pregnancy 58.14 12.49 131 134481 102418 46449032
Pancytopenia 57.95 12.49 432 134180 84626 46466824
Macular oedema 57.61 12.49 65 134547 4036 46547414
Pneumothorax 57.41 12.49 129 134483 14500 46536950
Dizziness 57.22 12.49 667 133945 339747 46211703
Bile duct stenosis 57.04 12.49 37 134575 1064 46550386
Tumour marker increased 56.48 12.49 60 134552 3481 46547969
Pulmonary arterial hypertension 56.25 12.49 5 134607 25923 46525527
Stress 56.18 12.49 40 134572 51511 46499939
Carbohydrate antigen 125 increased 55.63 12.49 50 134562 2360 46549090
Recall phenomenon 55.51 12.49 29 134583 549 46550901
Anaphylactoid reaction 55.41 12.49 59 134553 3432 46548018
Small intestinal perforation 55.17 12.49 38 134574 1210 46550240
Coronary artery disease 54.30 12.49 15 134597 33737 46517713
Myocardial infarction 54.14 12.49 126 134486 97402 46454048
Metastatic neoplasm 54.01 12.49 59 134553 3534 46547916
Performance status decreased 53.68 12.49 56 134556 3181 46548269
Invasive ductal breast carcinoma 53.64 12.49 77 134535 6091 46545359
Hyperaemia 53.39 12.49 45 134567 1947 46549503
Cerebrovascular accident 53.36 12.49 134 134478 100905 46450545
Multiple sclerosis 53.20 12.49 5 134607 24786 46526664
Nasal congestion 52.87 12.49 37 134575 48076 46503374
Neoplasm recurrence 52.36 12.49 48 134564 2325 46549125
Irritability 52.26 12.49 10 134602 28936 46522514
Wrong technique in product usage process 52.11 12.49 48 134564 54374 46497076
Lymphoedema 52.03 12.49 91 134521 8521 46542929
Blood pressure fluctuation 51.93 12.49 12 134600 30436 46521014
Surgery 51.86 12.49 10 134602 28775 46522675
Sleep apnoea syndrome 51.85 12.49 3 134609 22198 46529252
Diabetes mellitus 51.79 12.49 41 134571 50024 46501426
Triple negative breast cancer 51.14 12.49 18 134594 119 46551331
Cataract 51.14 12.49 34 134578 45381 46506069
Nervousness 51.07 12.49 10 134602 28465 46522985
Gastric disorder 50.90 12.49 8 134604 26697 46524753
Tumour haemorrhage 50.88 12.49 38 134574 1377 46550073
Metastases to kidney 50.84 12.49 20 134592 187 46551263
Osteoporosis 50.51 12.49 27 134585 40581 46510869
Fluid overload 49.92 12.49 9 134603 27176 46524274
Urticaria 49.50 12.49 174 134438 117718 46433732
Nephrolithiasis 49.02 12.49 17 134595 33034 46518416
Osteonecrosis 48.50 12.49 174 134438 25570 46525880
Nasal septum perforation 48.13 12.49 29 134583 730 46550720
Alveolitis 48.13 12.49 47 134565 2466 46548984
Red blood cell sedimentation rate increased 48.11 12.49 5 134607 22884 46528566
Pregnancy 47.69 12.49 10 134602 27127 46524323
Recurrent cancer 47.68 12.49 40 134572 1719 46549731
Metastases to pleura 47.58 12.49 33 134579 1063 46550387
Swollen tongue 47.00 12.49 13 134599 29219 46522231
Superior vena cava syndrome 46.81 12.49 26 134586 559 46550891
Serotonin syndrome 46.75 12.49 7 134605 24213 46527237
Bone lesion 46.51 12.49 64 134548 4867 46546583
Coma 46.42 12.49 60 134552 58289 46493161
Lactic acidosis 46.06 12.49 20 134592 33889 46517561
Urinary tract obstruction 46.04 12.49 39 134573 1699 46549751
Subclavian vein thrombosis 46.00 12.49 40 134572 1806 46549644
Tremor 45.71 12.49 175 134437 115464 46435986
Device related infection 45.58 12.49 149 134463 20892 46530558
Lower respiratory tract infection 45.55 12.49 55 134557 55034 46496416
Computerised tomogram thorax abnormal 45.51 12.49 35 134577 1326 46550124
Metastases to breast 44.53 12.49 20 134592 267 46551183
Eczema asteatotic 44.00 12.49 20 134592 275 46551175
Rhabdomyolysis 43.75 12.49 34 134578 41875 46509575
Joint injury 43.65 12.49 3 134609 19206 46532244
Pericardial effusion 43.40 12.49 167 134445 25376 46526074
Anaphylactic reaction 43.38 12.49 282 134330 52830 46498620
Metastases to chest wall 43.30 12.49 23 134589 451 46550999
Extravasation 43.23 12.49 41 134571 2074 46549376
Confusional state 43.04 12.49 277 134335 159615 46391835
Hypocalcaemia 42.98 12.49 172 134440 26613 46524837
Cholangitis sclerosing 42.75 12.49 30 134582 985 46550465
Drug dependence 42.74 12.49 4 134608 19897 46531553
Paronychia 42.67 12.49 59 134553 4507 46546943
Product quality issue 42.46 12.49 25 134587 35623 46515827
Atelectasis 42.46 12.49 135 134477 18655 46532795
Injection site haemorrhage 42.32 12.49 5 134607 20704 46530746
Carcinoembryonic antigen increased 42.30 12.49 34 134578 1375 46550075
Gastrooesophageal reflux disease 42.10 12.49 95 134517 74249 46477201
Joint stiffness 41.86 12.49 13 134599 27095 46524355
Pharyngeal fistula 41.62 12.49 10 134602 10 46551440
Disseminated intravascular coagulation 41.54 12.49 135 134477 18870 46532580
Oesophagobronchial fistula 41.44 12.49 12 134600 37 46551413
Ear infection 41.44 12.49 8 134604 23005 46528445
Dyskinesia 41.00 12.49 16 134596 28909 46522541
Limb injury 40.79 12.49 4 134608 19170 46532280
No adverse event 40.78 12.49 24 134588 34207 46517243
Metastases to pelvis 40.78 12.49 18 134594 230 46551220
Tumour lysis syndrome 40.56 12.49 74 134538 7162 46544288
Cardiac failure 40.54 12.49 380 134232 79568 46471882
Hepatic enzyme increased 40.49 12.49 112 134500 81675 46469775
Psychotic disorder 40.45 12.49 8 134604 22613 46528837
Lymphadenopathy mediastinal 40.17 12.49 42 134570 2392 46549058
Acute myelomonocytic leukaemia 40.07 12.49 17 134595 196 46551254
Palmar erythema 39.97 12.49 33 134579 1387 46550063
Constipation 39.71 12.49 714 133898 173383 46378067
Radiation pneumonitis 39.16 12.49 31 134581 1226 46550224
Intestinal obstruction 39.12 12.49 164 134448 25911 46525539
Crying 38.82 12.49 7 134605 21134 46530316
Pseudomembranous colitis 38.81 12.49 47 134565 3148 46548302
Oesophagitis 38.39 12.49 106 134506 13545 46537905
Bradycardia 38.13 12.49 84 134528 66214 46485236
Metastases to soft tissue 37.96 12.49 15 134597 142 46551308
Bronchial fistula 37.93 12.49 10 134602 19 46551431
Medication error 37.79 12.49 21 134591 30890 46520560
Rash pruritic 37.78 12.49 43 134569 44172 46507278
Malignant ascites 37.65 12.49 27 134585 918 46550532
International normalised ratio increased 37.51 12.49 48 134564 46835 46504615
Malignant peritoneal neoplasm 37.47 12.49 24 134588 675 46550775
Periodontitis 37.21 12.49 48 134564 3428 46548022
Underdose 36.96 12.49 6 134606 19552 46531898
Gastrointestinal necrosis 36.78 12.49 43 134569 2775 46548675
Female genital tract fistula 36.69 12.49 46 134566 3193 46548257
Endocarditis noninfective 36.61 12.49 11 134601 40 46551410
Cervix carcinoma 36.49 12.49 42 134570 2665 46548785
Toxic erythema of chemotherapy 36.40 12.49 11 134601 41 46551409
Suffocation feeling 36.19 12.49 30 134582 1268 46550182
Capillary permeability increased 36.06 12.49 10 134602 25 46551425
Product prescribing error 36.03 12.49 7 134605 20040 46531410
Onychalgia 35.94 12.49 23 134589 646 46550804
Adverse drug reaction 35.93 12.49 45 134567 44317 46507133
Radiation necrosis 35.93 12.49 18 134594 311 46551139
Renal disorder 35.83 12.49 16 134596 26670 46524780
Device related thrombosis 35.55 12.49 29 134583 1198 46550252
Metastases to abdominal wall 35.51 12.49 12 134600 69 46551381
Capillary leak syndrome 35.44 12.49 35 134577 1862 46549588
Radiation skin injury 35.33 12.49 25 134587 832 46550618
Hypomagnesaemia 35.14 12.49 142 134470 22068 46529382
Basal cell carcinoma 35.09 12.49 8 134604 20479 46530971
Administration site extravasation 34.69 12.49 22 134590 608 46550842
Hepatic lesion 34.40 12.49 49 134563 3848 46547602
Type I hypersensitivity 34.35 12.49 38 134574 2308 46549142
Aortitis 34.31 12.49 23 134589 700 46550750
Dermatitis acneiform 34.21 12.49 50 134562 4020 46547430
Adenocarcinoma 34.18 12.49 38 134574 2321 46549129
Therapy cessation 34.16 12.49 17 134595 26612 46524838
Eye pain 34.13 12.49 19 134593 27921 46523529
Hyperpyrexia 34.11 12.49 41 134571 2725 46548725
Hypoalbuminaemia 33.97 12.49 84 134528 10043 46541407
Nightmare 33.94 12.49 4 134608 16594 46534856
Metabolic acidosis 33.92 12.49 37 134575 38743 46512707
Gallbladder disorder 33.90 12.49 5 134607 17493 46533957
Anastomotic leak 33.86 12.49 19 134593 417 46551033
Ovarian cancer metastatic 33.83 12.49 24 134588 802 46550648
Irritable bowel syndrome 33.72 12.49 4 134608 16511 46534939
Laboratory test abnormal 33.45 12.49 12 134600 22835 46528615
Sepsis 33.21 12.49 564 134048 135450 46416000
Adverse event 32.90 12.49 30 134582 34154 46517296
Fear 32.81 12.49 4 134608 16168 46535282
Device dislocation 32.70 12.49 11 134601 21791 46529659
Treatment noncompliance 32.48 12.49 23 134589 29708 46521742
Bronchostenosis 32.16 12.49 17 134595 330 46551120
Scleroderma-like reaction 32.15 12.49 11 134601 66 46551384
Glaucoma 32.15 12.49 4 134608 15917 46535533
Scleroderma 32.07 12.49 52 134560 4577 46546873
Eosinophilia 31.94 12.49 8 134604 19209 46532241
Vocal cord paralysis 31.89 12.49 31 134581 1617 46549833
Injection site rash 31.87 12.49 4 134608 15809 46535641
Acne 31.76 12.49 9 134603 19910 46531540
Biliary sepsis 31.66 12.49 20 134592 549 46550901
Herpes zoster 31.36 12.49 96 134516 67776 46483674
Lymphocele 31.24 12.49 23 134589 815 46550635
Alopecia 31.21 12.49 649 133963 161765 46389685
Blood glucose increased 31.09 12.49 105 134507 71908 46479542
Hormone receptor positive breast cancer 31.01 12.49 18 134594 422 46551028
Panic attack 30.73 12.49 10 134602 20232 46531218
Flatulence 30.69 12.49 23 134589 28855 46522595
Dysgeusia 30.66 12.49 211 134401 40280 46511170
Road traffic accident 30.58 12.49 15 134597 23676 46527774
Gait inability 30.33 12.49 34 134578 35169 46516281
Colitis 30.31 12.49 198 134414 37149 46514301
Enterocolitis infectious 30.30 12.49 29 134583 1484 46549966
Primary cardiac lymphoma 30.11 12.49 9 134603 32 46551418
Device issue 30.11 12.49 10 134602 19970 46531480
Wound 30.11 12.49 48 134564 42754 46508696
Amnesia 29.94 12.49 46 134566 41585 46509865
Pneumonia 29.74 12.49 842 133770 375478 46175972
Head injury 29.74 12.49 17 134595 24619 46526831
Sleep disorder 29.70 12.49 56 134556 46739 46504711
Pneumonitis chemical 29.60 12.49 13 134599 164 46551286
Poisoning 29.56 12.49 3 134609 13991 46537459
Invasive lobular breast carcinoma 29.45 12.49 20 134592 622 46550828
Osteolysis 29.43 12.49 37 134575 2575 46548875
Product administration error 29.40 12.49 10 134602 19671 46531779
Upper limb fracture 29.29 12.49 5 134607 15708 46535742
Hot flush 29.04 12.49 220 134392 43297 46508153
Therapeutic response unexpected 29.04 12.49 5 134607 15611 46535839
Tumour embolism 29.03 12.49 12 134600 129 46551321
Hypersensitivity pneumonitis 28.97 12.49 35 134577 2338 46549112
Ankle fracture 28.77 12.49 5 134607 15506 46535944
Electrocardiogram QT prolonged 28.72 12.49 66 134546 51259 46500191
Cardiac cirrhosis 28.39 12.49 12 134600 137 46551313
Onychomadesis 28.28 12.49 38 134574 2825 46548625
Pulse absent 28.18 12.49 51 134561 4905 46546545
Neuromuscular toxicity 27.93 12.49 12 134600 143 46551307
Balance disorder 27.90 12.49 94 134518 64427 46487023
Kidney infection 27.88 12.49 7 134605 16782 46534668
Pancreatitis 27.88 12.49 52 134560 43575 46507875
Hyperhidrosis 27.82 12.49 386 134226 88922 46462528
Angioedema 27.78 12.49 44 134568 39298 46512152
Mental disorder 27.75 12.49 15 134597 22410 46529040
Transient ischaemic attack 27.65 12.49 36 134576 34867 46516583
Cytomegalovirus infection 27.48 12.49 9 134603 18135 46533315
Procedural pain 27.39 12.49 3 134609 13176 46538274
Hypertensive crisis 27.35 12.49 94 134518 13521 46537929
Upper respiratory tract infection 27.21 12.49 93 134519 63463 46487987
Emotional distress 27.18 12.49 29 134583 30678 46520772
Accidental overdose 26.99 12.49 12 134600 20054 46531396
Choking sensation 26.71 12.49 40 134572 3287 46548163
Duodenitis haemorrhagic 26.65 12.49 7 134605 13 46551437
Lung infiltration 26.52 12.49 95 134517 13948 46537502
Drug level increased 26.47 12.49 10 134602 18431 46533019
Metastases to eye 26.38 12.49 11 134601 121 46551329
Duodenal perforation 26.37 12.49 21 134591 838 46550612
Splenic artery thrombosis 26.31 12.49 7 134605 14 46551436
Infusion related hypersensitivity reaction 26.31 12.49 7 134605 14 46551436
Right ventricular failure 26.17 12.49 7 134605 16086 46535364
Porokeratosis 26.07 12.49 11 134601 125 46551325
Acute interstitial pneumonitis 25.87 12.49 19 134593 671 46550779
Full blood count decreased 25.86 12.49 16 134596 22195 46529255
Eye disorder 25.77 12.49 10 134602 18131 46533319
Wheezing 25.75 12.49 74 134538 53312 46498138
Aggression 25.64 12.49 17 134595 22727 46528723
Blood uric acid decreased 25.43 12.49 17 134595 515 46550935
Thyroid dermatopathy 25.39 12.49 7 134605 17 46551433
Secondary cerebellar degeneration 25.39 12.49 7 134605 17 46551433
Viral infection 25.19 12.49 30 134582 30205 46521245
Hallucination, visual 25.14 12.49 10 134602 17863 46533587
Neck pain 25.00 12.49 79 134533 55227 46496223
Double hit lymphoma 24.97 12.49 6 134606 6 46551444
Thrombotic microangiopathy 24.86 12.49 66 134546 8240 46543210
Weight decreased 24.83 12.49 443 134169 210406 46341044
Abnormal behaviour 24.75 12.49 15 134597 21043 46530407
Mood swings 24.72 12.49 8 134604 16244 46535206
Acute lymphocytic leukaemia 24.68 12.49 35 134577 2738 46548712
Cardiac failure congestive 24.64 12.49 159 134453 91591 46459859
Femur fracture 24.62 12.49 43 134569 36954 46514496
Oropharyngeal pain 24.55 12.49 120 134492 74048 46477402
Deep vein thrombosis 24.52 12.49 344 134268 79429 46472021
Embryonal rhabdomyosarcoma 24.49 12.49 6 134606 7 46551443
Rectal perforation 24.40 12.49 15 134597 392 46551058
Lymphopenia 24.37 12.49 98 134514 15195 46536255
Congestive cardiomyopathy 24.25 12.49 52 134560 5661 46545789
Jugular vein thrombosis 24.20 12.49 34 134578 2636 46548814
Pulmonary toxicity 23.82 12.49 46 134566 4647 46546803
Renal failure 23.80 12.49 211 134401 113383 46438067
Carpal tunnel syndrome 23.79 12.49 8 134604 15851 46535599
COVID-19 23.61 12.49 12 134600 18563 46532887
Impaired work ability 23.60 12.49 4 134608 12632 46538818
Wound dehiscence 23.56 12.49 45 134567 4509 46546941
Bursitis 23.51 12.49 14 134598 19828 46531622
Skin laceration 23.45 12.49 12 134600 18490 46532960
Drug ineffective for unapproved indication 23.39 12.49 9 134603 16404 46535046
Immune-mediated hepatitis 23.33 12.49 17 134595 593 46550857
Cancer fatigue 23.18 12.49 7 134605 26 46551424
Cachexia 23.10 12.49 46 134566 4753 46546697
Chills 22.99 12.49 397 134215 95635 46455815
Gastrointestinal fistula 22.98 12.49 15 134597 436 46551014
Wrist fracture 22.96 12.49 3 134609 11500 46539950
Foot fracture 22.95 12.49 14 134598 19568 46531882
Peritoneal disorder 22.94 12.49 16 134596 520 46550930
Blood bilirubin increased 22.91 12.49 173 134439 34011 46517439
Cerebral ischaemia 22.86 12.49 54 134558 6271 46545179
Emotional disorder 22.80 12.49 4 134608 12320 46539130
Foot deformity 22.76 12.49 8 134604 15417 46536033
Haemoglobin 22.66 12.49 11 134601 177 46551273
Diverticulitis 22.35 12.49 38 134574 33001 46518449
Tooth erosion 22.16 12.49 15 134597 464 46550986
Venous thrombosis 22.15 12.49 45 134567 4717 46546733
Joint dislocation 22.13 12.49 3 134609 11183 46540267
Sinus disorder 22.13 12.49 10 134602 16553 46534897
Sopor 22.11 12.49 15 134597 19813 46531637
Anaemia of malignant disease 21.98 12.49 14 134598 390 46551060
Mastitis 21.93 12.49 30 134582 2268 46549182
Peritoneal fibrosis 21.92 12.49 5 134607 3 46551447
Brachiocephalic vein thrombosis 21.87 12.49 8 134604 60 46551390
Ocular hyperaemia 21.86 12.49 15 134597 19695 46531755
Hepatic function abnormal 21.85 12.49 172 134440 34249 46517201
Hyperkalaemia 21.84 12.49 74 134538 50635 46500815
Seizure 21.82 12.49 238 134374 122816 46428634
Dermatomyositis 21.78 12.49 28 134584 1993 46549457
Incorrect route of product administration 21.72 12.49 10 134602 16373 46535077
Radiation oesophagitis 21.69 12.49 12 134600 256 46551194
Vena cava thrombosis 21.64 12.49 29 134583 2150 46549300
Hepatic vein thrombosis 21.59 12.49 9 134603 99 46551351
Vessel puncture site bruise 21.55 12.49 13 134599 328 46551122
Blood glucose decreased 21.46 12.49 14 134598 18878 46532572
Musculoskeletal disorder 21.38 12.49 9 134603 15536 46535914
BRAF gene mutation 21.36 12.49 7 134605 36 46551414
Lymphatic disorder 21.34 12.49 13 134599 334 46551116
Helicobacter infection 21.30 12.49 4 134608 11732 46539718
Intracranial tumour haemorrhage 21.28 12.49 10 134602 149 46551301
Neutropenic infection 21.27 12.49 21 134591 1117 46550333
Hypersomnia 21.13 12.49 9 134603 15430 46536020
Gastroenteritis radiation 21.10 12.49 15 134597 503 46550947
Transfusion 21.06 12.49 6 134606 13225 46538225
Venous thrombosis limb 20.99 12.49 33 134579 2830 46548620
Vesical fistula 20.90 12.49 8 134604 69 46551381
Gelastic seizure 20.81 12.49 5 134607 5 46551445
Pulmonary tumour thrombotic microangiopathy 20.75 12.49 7 134605 40 46551410
Mediastinitis 20.69 12.49 11 134601 216 46551234
Protein urine 20.67 12.49 16 134596 612 46550838
Blood count abnormal 20.65 12.49 13 134599 17865 46533585
Cholelithiasis 20.64 12.49 51 134561 38630 46512820
Nail ridging 20.56 12.49 11 134601 219 46551231
Agitation 20.53 12.49 86 134526 55329 46496121
Swelling face 20.50 12.49 81 134531 52978 46498472
Neutrophil count abnormal 20.45 12.49 30 134582 2420 46549030
Tonsillar disorder 20.44 12.49 19 134593 937 46550513
Pulmonary vein stenosis 20.41 12.49 8 134604 74 46551376
Gout 20.34 12.49 4 134608 11352 46540098
Colitis ulcerative 20.33 12.49 13 134599 17719 46533731
Tumour ulceration 20.32 12.49 9 134603 116 46551334
Portal vein thrombosis 20.29 12.49 30 134582 2437 46549013
Enterocutaneous fistula 20.18 12.49 21 134591 1189 46550261
Product complaint 20.18 12.49 5 134607 12096 46539354
Thyroid disorder 20.12 12.49 5 134607 12071 46539379
Eosinophil percentage increased 20.11 12.49 18 134594 845 46550605
Diabetic ketoacidosis 20.01 12.49 14 134598 18196 46533254
Delirium 19.93 12.49 49 134563 37179 46514271
Breast ulceration 19.92 12.49 7 134605 46 46551404
Tumour pain 19.91 12.49 21 134591 1208 46550242
Product supply issue 19.84 12.49 18 134594 860 46550590
Movement disorder 19.81 12.49 12 134600 16837 46534613
Hip arthroplasty 19.80 12.49 14 134598 18098 46533352
Inflammation 19.79 12.49 73 134539 48708 46502742
Influenza like illness 19.72 12.49 92 134520 57478 46493972
Eye pruritus 19.68 12.49 5 134607 11893 46539557
Faeces discoloured 19.67 12.49 12 134600 16775 46534675
Hepatitis B reactivation 19.59 12.49 23 134589 1491 46549959
Acute kidney injury 19.55 12.49 524 134088 235331 46316119
Emphysematous cystitis 19.53 12.49 9 134603 128 46551322
Disability 19.48 12.49 3 134609 10164 46541286
Lymphadenopathy 19.45 12.49 164 134448 33324 46518126
Intestinal metastasis 19.43 12.49 7 134605 50 46551400
Neoplasm 19.40 12.49 48 134564 5740 46545710
Metastases to adrenals 19.37 12.49 16 134596 673 46550777
Seroma 19.35 12.49 27 134585 2080 46549370
Vaginal fistula 19.29 12.49 13 134599 399 46551051
Retroperitoneal lymphadenopathy 19.22 12.49 14 134598 488 46550962
HER2 positive breast cancer 19.03 12.49 8 134604 90 46551360
Metastases to thorax 19.01 12.49 10 134602 192 46551258
Respiratory distress 18.91 12.49 157 134455 31759 46519691
Laryngeal cancer stage III 18.79 12.49 5 134607 10 46551440
Mood altered 18.76 12.49 7 134605 13000 46538450
Metastases to ovary 18.75 12.49 12 134600 337 46551113
Night sweats 18.75 12.49 31 134581 27219 46524231
Blood potassium increased 18.70 12.49 13 134599 16954 46534496
Abdominal infection 18.68 12.49 24 134588 1707 46549743
Xerophthalmia 18.61 12.49 11 134601 267 46551183
Hypophosphataemia 18.57 12.49 55 134557 7312 46544138
Pelvic abscess 18.57 12.49 22 134590 1440 46550010
Accidental exposure to product 18.56 12.49 20 134592 21061 46530389
Urinary retention 18.54 12.49 29 134583 26032 46525418
Carbohydrate antigen 19-9 increased 18.47 12.49 9 134603 146 46551304
Cardiac murmur 18.47 12.49 5 134607 11399 46540051
Tooth extraction 18.44 12.49 68 134544 10125 46541325
Transaminases increased 18.33 12.49 140 134472 27621 46523829
Blood pressure immeasurable 18.18 12.49 20 134592 1207 46550243
Cholecystitis chronic 18.18 12.49 4 134608 10495 46540955
Neutropenic colitis 18.16 12.49 27 134585 2205 46549245
Fungal infection 18.15 12.49 36 134576 29484 46521966
Prescribed overdose 18.05 12.49 4 134608 10445 46541005
Pelvic infection 18.04 12.49 11 134601 283 46551167
Device malfunction 17.98 12.49 8 134604 13366 46538084
Eye irritation 17.95 12.49 13 134599 16601 46534849
Postoperative adhesion 17.92 12.49 10 134602 217 46551233
Seasonal allergy 17.89 12.49 8 134604 13326 46538124
Aorto-oesophageal fistula 17.89 12.49 5 134607 13 46551437
Gastrointestinal haemorrhage 17.89 12.49 140 134472 77233 46474217
Scintillating scotoma 17.83 12.49 9 134603 158 46551292
Poor quality sleep 17.74 12.49 11 134601 15242 46536208
Ovarian failure 17.73 12.49 19 134593 1113 46550337
Hepatic cirrhosis 17.72 12.49 91 134521 15641 46535809
Spinal stenosis 17.67 12.49 7 134605 12536 46538914
Restless legs syndrome 17.64 12.49 12 134600 15831 46535619
Metastases to bladder 17.63 12.49 9 134603 162 46551288
Bone erosion 17.61 12.49 3 134609 9440 46542010
Tuberculosis 17.59 12.49 4 134608 10261 46541189
Vulvovaginal inflammation 17.59 12.49 14 134598 558 46550892
Joint range of motion decreased 17.46 12.49 11 134601 15113 46536337
Non-small cell lung cancer 17.43 12.49 32 134580 3112 46548338
Orbital myositis 17.37 12.49 5 134607 15 46551435
Gastroenteritis viral 17.32 12.49 16 134596 18103 46533347
Ear pain 17.28 12.49 23 134589 22069 46529381
Respiratory depth decreased 17.27 12.49 6 134606 38 46551412
Duodenal obstruction 17.25 12.49 10 134602 234 46551216
Drug resistance 17.22 12.49 97 134515 17271 46534179
Metastases to stomach 17.16 12.49 8 134604 117 46551333
Cough 17.16 12.49 820 133792 229429 46322021
Vaginal perforation 17.13 12.49 5 134607 16 46551434
Subdural haematoma 17.12 12.49 8 134604 12989 46538461
Oesophageal stenosis 17.08 12.49 30 134582 2819 46548631
Blood pressure systolic increased 16.94 12.49 36 134576 28751 46522699
Metastases to muscle 16.92 12.49 8 134604 121 46551329
Angiosarcoma 16.91 12.49 10 134602 243 46551207
Tumour fistulisation 16.90 12.49 5 134607 17 46551433
Endometrial cancer metastatic 16.86 12.49 8 134604 122 46551328
Productive cough 16.81 12.49 82 134530 50633 46500817
Chest pain 16.73 12.49 644 133968 175680 46375770
Aortic dissection rupture 16.65 12.49 4 134608 4 46551446
Hydroureter 16.61 12.49 11 134601 328 46551122
Pneumonia aspiration 16.60 12.49 42 134570 31563 46519887
Respiratory tract congestion 16.60 12.49 8 134604 12756 46538694
Cholecystectomy 16.59 12.49 3 134609 9039 46542411
Tumour invasion 16.57 12.49 8 134604 127 46551323
Transaminases 16.55 12.49 7 134605 80 46551370
Bone marrow infiltration 16.53 12.49 12 134600 416 46551034
Liver scan abnormal 16.52 12.49 6 134606 44 46551406
Thinking abnormal 16.47 12.49 4 134608 9810 46541640
Post procedural fistula 16.41 12.49 10 134602 257 46551193
Peritonitis 16.31 12.49 109 134503 20605 46530845
Cancer pain 16.27 12.49 27 134585 2423 46549027
Bone sequestrum 16.21 12.49 22 134590 1651 46549799
Delusion 16.17 12.49 6 134606 11182 46540268
Speech disorder 16.11 12.49 52 134560 36115 46515335
Anger 16.08 12.49 7 134605 11845 46539605
Blood creatine phosphokinase increased 16.04 12.49 35 134577 27689 46523761
Product storage error 15.94 12.49 7 134605 11785 46539665
Bladder perforation 15.93 12.49 8 134604 139 46551311
Ileal perforation 15.92 12.49 11 134601 352 46551098
Sinus congestion 15.89 12.49 9 134603 13100 46538350
Lividity 15.86 12.49 9 134603 202 46551248
Adenocarcinoma pancreas 15.82 12.49 18 134594 1128 46550322
Myoclonus 15.81 12.49 11 134601 14341 46537109
Embolism venous 15.81 12.49 27 134585 2480 46548970
Hypotension 15.81 12.49 821 133791 231768 46319682
Pulmonary artery stenosis 15.77 12.49 8 134604 142 46551308
Disturbance in attention 15.77 12.49 43 134569 31517 46519933
Haemolytic uraemic syndrome 15.76 12.49 27 134585 2487 46548963
Dementia 15.72 12.49 12 134600 14918 46536532
Sciatica 15.71 12.49 19 134593 19001 46532449
Bacterial diarrhoea 15.65 12.49 6 134606 52 46551398
Hereditary motor and sensory neuropathy 15.65 12.49 6 134606 52 46551398
Vision blurred 15.42 12.49 151 134461 79557 46471893
Angiodermatitis 15.42 12.49 7 134605 96 46551354
Vaginal cuff dehiscence 15.38 12.49 4 134608 7 46551443
Severe acute respiratory syndrome 15.38 12.49 4 134608 7 46551443
Maternal death affecting foetus 15.38 12.49 4 134608 7 46551443
Schizophrenia 15.38 12.49 3 134609 8565 46542885
Blood loss anaemia 15.35 12.49 3 134609 8554 46542896
Acute respiratory distress syndrome 15.29 12.49 112 134500 21810 46529640
Foetal exposure during pregnancy 15.29 12.49 42 134570 30705 46520745
Ovarian cyst 15.25 12.49 11 134601 14076 46537374
Sputum discoloured 15.16 12.49 9 134603 12769 46538681
Pharyngitis streptococcal 15.13 12.49 3 134609 8465 46542985
Ototoxicity 15.11 12.49 17 134595 1052 46550398
Myeloproliferative neoplasm 15.06 12.49 12 134600 479 46550971
Product dispensing error 15.04 12.49 4 134608 9229 46542221
Application site recall reaction 15.04 12.49 4 134608 8 46551442
Distal intestinal obstruction syndrome 15.04 12.49 11 134601 386 46551064
Arterioenteric fistula 15.04 12.49 4 134608 8 46551442
Debridement 15.02 12.49 19 134593 1331 46550119
Prescribed underdose 15.01 12.49 8 134604 12045 46539405
Guillain-Barre syndrome 14.99 12.49 31 134581 3291 46548159
Hip fracture 14.97 12.49 34 134578 26522 46524928
Photophobia 14.92 12.49 12 134600 14532 46536918
Median nerve injury 14.90 12.49 5 134607 28 46551422
Clonal evolution 14.90 12.49 6 134606 60 46551390
Immediate post-injection reaction 14.89 12.49 11 134601 392 46551058
Joint effusion 14.88 12.49 8 134604 11987 46539463
Hypokinesia 14.87 12.49 7 134605 11315 46540135
Oesophageal squamous cell carcinoma 14.80 12.49 7 134605 106 46551344
Renal impairment 14.77 12.49 140 134472 74232 46477218
Cervix carcinoma recurrent 14.76 12.49 5 134607 29 46551421
Extrapyramidal disorder 14.75 12.49 7 134605 11261 46540189
Cystitis haemorrhagic 14.73 12.49 32 134580 3515 46547935
Bronchopleural fistula 14.71 12.49 9 134603 233 46551217
Eastern Cooperative Oncology Group performance status worsened 14.70 12.49 11 134601 400 46551050
Limb discomfort 14.68 12.49 27 134585 22749 46528701
Eye swelling 14.66 12.49 22 134590 20081 46531369
Hepatic cancer metastatic 14.64 12.49 10 134602 314 46551136
Obstructive shock 14.62 12.49 5 134607 30 46551420
Pleural neoplasm 14.57 12.49 7 134605 110 46551340
Ankyloglossia acquired 14.56 12.49 3 134609 0 46551450
Chest wall necrosis 14.56 12.49 3 134609 0 46551450
Granulocyte count 14.56 12.49 3 134609 0 46551450
Lymphatic obstruction 14.56 12.49 3 134609 0 46551450
Myiasis 14.56 12.49 3 134609 0 46551450
Ovarian cancer stage IV 14.55 12.49 6 134606 64 46551386
Brain cancer metastatic 14.55 12.49 6 134606 64 46551386
Sensory disturbance 14.55 12.49 72 134540 12195 46539255
Loss of consciousness 14.55 12.49 412 134200 107826 46443624
Metastases to abdominal cavity 14.55 12.49 11 134601 406 46551044
Breast cellulitis 14.52 12.49 12 134600 505 46550945
Cardiac disorder 14.49 12.49 71 134541 43787 46507663
Thrombophlebitis migrans 14.48 12.49 5 134607 31 46551419
Clonal haematopoiesis 14.43 12.49 4 134608 10 46551440
Febrile infection 14.41 12.49 18 134594 1245 46550205
Metastatic gastric cancer 14.40 12.49 8 134604 172 46551278
Electrolyte imbalance 14.39 12.49 92 134520 17134 46534316
Hernia 14.35 12.49 5 134607 9690 46541760
Pulmonary congestion 14.22 12.49 13 134599 14786 46536664
Polymicrogyria 14.16 12.49 6 134606 69 46551381
Laryngeal necrosis 14.15 12.49 4 134608 11 46551439
Acute myocardial infarction 14.15 12.49 46 134566 31878 46519572
Purulent discharge 14.07 12.49 38 134574 4792 46546658
Rash papular 14.06 12.49 10 134602 12888 46538562
Rotator cuff syndrome 13.97 12.49 8 134604 11575 46539875
Transaminases abnormal 13.93 12.49 12 134600 535 46550915
Enteritis 13.88 12.49 47 134565 6708 46544742
Pulmonary hypertension 13.87 12.49 55 134557 35938 46515512
Glycosylated haemoglobin increased 13.86 12.49 7 134605 10869 46540581
Lichenoid keratosis 13.85 12.49 18 134594 1295 46550155
Catheter site thrombosis 13.82 12.49 7 134605 124 46551326
Torsade de pointes 13.81 12.49 9 134603 12145 46539305
Hyperlipidaemia 13.80 12.49 20 134592 18519 46532931
Infected lymphocele 13.77 12.49 8 134604 188 46551262
Ovarian clear cell carcinoma 13.66 12.49 4 134608 13 46551437
Peripheral paralysis 13.64 12.49 6 134606 76 46551374
Cholangitis acute 13.60 12.49 11 134601 449 46551001
Pulpitis dental 13.60 12.49 14 134598 783 46550667
Hallucination, auditory 13.60 12.49 7 134605 10749 46540701
Nail infection 13.58 12.49 21 134591 1775 46549675
Hypothalamo-pituitary disorder 13.55 12.49 13 134599 667 46550783
Discomfort 13.50 12.49 79 134533 46591 46504859
Uterine adhesions 13.50 12.49 5 134607 39 46551411
Thyroiditis 13.50 12.49 20 134592 1628 46549822
Lung carcinoma cell type unspecified stage III 13.50 12.49 5 134607 39 46551411
Nail dystrophy 13.49 12.49 11 134601 454 46550996
Hysterectomy 13.46 12.49 3 134609 7803 46543647
Dysuria 13.46 12.49 131 134481 27702 46523748
Aplasia 13.44 12.49 31 134581 3545 46547905
Papilloedema 13.43 12.49 31 134581 3546 46547904
Exposed bone in jaw 13.39 12.49 29 134583 3179 46548271
Blood magnesium decreased 13.39 12.49 65 134547 10927 46540523
Failure to thrive 13.37 12.49 46 134566 6618 46544832
Increased appetite 13.32 12.49 4 134608 8523 46542927
Cervix cancer metastatic 13.28 12.49 5 134607 41 46551409
Periodontal disease 13.25 12.49 20 134592 1655 46549795
Paranoia 13.24 12.49 7 134605 10590 46540860
Peritoneal carcinoma metastatic 13.22 12.49 4 134608 15 46551435
Calcium ionised increased 13.14 12.49 7 134605 138 46551312
Respiratory fatigue 13.10 12.49 6 134606 84 46551366
Drug-induced liver injury 13.10 12.49 34 134578 25334 46526116
Laryngeal discomfort 13.08 12.49 9 134603 286 46551164
Toxic neuropathy 13.07 12.49 10 134602 376 46551074
Intestinal prolapse 13.05 12.49 7 134605 140 46551310
Fistula of small intestine 13.03 12.49 9 134603 288 46551162
Blood triglycerides increased 13.02 12.49 9 134603 11774 46539676
Localised infection 13.00 12.49 31 134581 23770 46527680
Spinal fracture 12.95 12.49 15 134597 15290 46536160
Abscess drainage 12.89 12.49 11 134601 484 46550966
Opsoclonus myoclonus 12.88 12.49 7 134605 144 46551306
Mediastinum neoplasm 12.82 12.49 4 134608 17 46551433
Metastases to vagina 12.82 12.49 4 134608 17 46551433
Endometrial cancer recurrent 12.82 12.49 4 134608 17 46551433
Morphoea 12.81 12.49 9 134603 296 46551154
Liver function test abnormal 12.76 12.49 80 134532 46407 46505043
Post procedural infection 12.73 12.49 3 134609 7510 46543940
Abdominal abscess 12.71 12.49 33 134579 4066 46547384
Acquired gene mutation 12.70 12.49 12 134600 604 46550846
Anhedonia 12.66 12.49 7 134605 10328 46541122
Thirst 12.65 12.49 8 134604 10968 46540482
Ovarian epithelial cancer recurrent 12.64 12.49 4 134608 18 46551432
Respiratory depression 12.63 12.49 9 134603 11591 46539859
Status epilepticus 12.60 12.49 13 134599 13966 46537484
Hydrothorax 12.59 12.49 12 134600 611 46550839
EGFR gene mutation 12.58 12.49 7 134605 151 46551299
Ureteric stenosis 12.55 12.49 12 134600 613 46550837
Cytopenia 12.55 12.49 50 134562 7718 46543732
Exostosis 12.50 12.49 7 134605 10256 46541194
Dandy-Walker syndrome 12.50 12.49 6 134606 94 46551356
Stress cardiomyopathy 12.50 12.49 50 134562 7734 46543716

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 536.82 15.11 719 43266 105974 29802519
Neutropenia 519.45 15.11 780 43205 127760 29780733
Malignant neoplasm progression 422.38 15.11 525 43460 71762 29836731
Pancreatic carcinoma metastatic 355.13 15.11 145 43840 3102 29905391
Interstitial lung disease 351.15 15.11 437 43548 59760 29848733
Pancreatic carcinoma 310.39 15.11 174 43811 7663 29900830
Leukopenia 224.84 15.11 340 43645 55819 29852674
Thrombocytopenia 203.58 15.11 548 43437 136496 29771997
Disease progression 202.78 15.11 395 43590 79479 29829014
Neuropathy peripheral 200.59 15.11 366 43619 70109 29838384
Pneumonitis 180.54 15.11 212 43773 27242 29881251
Alopecia 176.02 15.11 177 43808 19098 29889395
Non-small cell lung cancer 175.94 15.11 93 43892 3637 29904856
Anaemia 174.54 15.11 684 43301 207308 29701185
Dehydration 174.40 15.11 485 43500 123054 29785439
Mucosal inflammation 167.42 15.11 215 43770 30279 29878214
Neutrophil count decreased 165.55 15.11 254 43731 42200 29866293
Death 131.25 15.11 934 43051 356349 29552144
Drug ineffective 128.15 15.11 189 43796 340198 29568295
Cholangitis 126.04 15.11 99 43886 7703 29900790
Completed suicide 124.46 15.11 5 43980 99487 29809006
Bone marrow failure 121.45 15.11 182 43803 29603 29878890
Flushing 118.53 15.11 179 43806 29313 29879180
Haemoptysis 115.61 15.11 182 43803 30896 29877597
Metastases to central nervous system 114.60 15.11 91 43894 7193 29901300
Haematotoxicity 112.18 15.11 84 43901 6086 29902407
Radiation pneumonitis 106.30 15.11 54 43931 1942 29906551
Dyspnoea 103.48 15.11 838 43147 332457 29576036
Product dose omission issue 101.40 15.11 9 43976 91622 29816871
Overdose 91.40 15.11 9 43976 84328 29824165
Oesophagitis 88.33 15.11 95 43890 11076 29897417
Pyrexia 87.81 15.11 734 43251 293755 29614738
General physical health deterioration 82.91 15.11 328 43657 99616 29808877
Pneumothorax 82.35 15.11 110 43875 16083 29892410
Cystoid macular oedema 79.73 15.11 32 43953 653 29907840
Radiation oesophagitis 78.51 15.11 27 43958 350 29908143
Erythema 77.44 15.11 270 43715 77181 29831312
Polyneuropathy 73.88 15.11 89 43896 11734 29896759
Fall 72.16 15.11 97 43888 181775 29726718
Sepsis 70.77 15.11 411 43574 145984 29762509
Decreased appetite 70.62 15.11 418 43567 149492 29759001
Neurotoxicity 69.26 15.11 91 43894 13091 29895402
White blood cell count decreased 67.58 15.11 273 43712 83674 29824819
Plasma cell myeloma 65.78 15.11 3 43982 53459 29855034
Drug interaction 65.37 15.11 121 43864 199447 29709046
Myelosuppression 64.55 15.11 66 43919 7256 29901237
Nausea 62.51 15.11 688 43297 296269 29612224
Biliary tract infection 62.22 15.11 24 43961 439 29908054
Depression 61.34 15.11 28 43957 90409 29818084
Headache 61.06 15.11 109 43876 182197 29726296
Pancytopenia 60.98 15.11 267 43718 84785 29823708
Neoplasm progression 60.79 15.11 101 43884 17922 29890571
Toxicity to various agents 60.18 15.11 105 43880 177078 29731415
Immune-mediated hepatitis 58.86 15.11 30 43955 1086 29907407
Pneumonia 58.68 15.11 748 43237 333558 29574935
Gastrointestinal perforation 58.65 15.11 46 43939 3570 29904923
Hypersensitivity 58.06 15.11 193 43792 53835 29854658
Vomiting 56.09 15.11 530 43455 219288 29689205
Metastases to lung 55.26 15.11 63 43922 7832 29900661
Metastases to liver 54.39 15.11 77 43908 11888 29896605
Infusion related reaction 53.86 15.11 156 43829 40408 29868085
Nasopharyngitis 52.81 15.11 11 43974 58838 29849655
Coronary artery disease 52.06 15.11 6 43979 49706 29858787
Peripheral sensory neuropathy 51.67 15.11 53 43932 5848 29902645
Somnolence 51.51 15.11 40 43945 96723 29811770
Insomnia 50.43 15.11 38 43947 93298 29815195
Weight increased 48.05 15.11 25 43960 74888 29833605
Platelet count decreased 48.03 15.11 293 43692 105836 29802657
Dysphagia 46.08 15.11 185 43800 56513 29851980
Anaphylactic shock 45.30 15.11 77 43908 13916 29894577
Joint swelling 43.75 15.11 8 43977 46938 29861555
Rheumatoid arthritis 43.07 15.11 5 43980 41192 29867301
Tracheo-oesophageal fistula 42.90 15.11 18 43967 413 29908080
Kounis syndrome 42.60 15.11 28 43957 1645 29906848
Hospitalisation 42.51 15.11 7 43978 44312 29864181
Psoriasis 42.40 15.11 6 43979 42500 29865993
Bronchial fistula 42.39 15.11 14 43971 159 29908334
Suicidal ideation 41.45 15.11 3 43982 36111 29872382
Liver abscess 41.41 15.11 36 43949 3226 29905267
Pulmonary radiation injury 41.15 15.11 11 43974 55 29908438
Anxiety 40.84 15.11 43 43942 89828 29818665
Tumour haemorrhage 40.65 15.11 32 43953 2496 29905997
Metastases to meninges 40.46 15.11 24 43961 1175 29907318
Recall phenomenon 40.27 15.11 19 43966 580 29907913
Suicide attempt 39.52 15.11 4 43981 36693 29871800
Cardiac failure congestive 38.79 15.11 40 43945 84367 29824126
Oxygen saturation decreased 38.76 15.11 146 43839 43294 29865199
Device failure 38.50 15.11 29 43956 2119 29906374
Oesophagopleural fistula 38.18 15.11 8 43977 9 29908484
Scleroderma-like reaction 38.07 15.11 9 43976 24 29908469
Pulmonary embolism 37.43 15.11 219 43766 77916 29830577
Aggression 37.31 15.11 5 43980 36902 29871591
Tumour necrosis 37.20 15.11 22 43963 1071 29907422
Intentional product misuse 36.76 15.11 4 43981 34663 29873830
Embolism 36.22 15.11 48 43937 6961 29901532
Intestinal perforation 36.05 15.11 53 43932 8466 29900027
Haemolytic uraemic syndrome 35.82 15.11 27 43958 1975 29906518
Hypoglycaemia 35.79 15.11 15 43970 50966 29857527
Thrombotic microangiopathy 35.62 15.11 53 43932 8557 29899936
Hallucination 35.15 15.11 14 43971 49045 29859448
Diarrhoea 35.01 15.11 686 43299 333417 29575076
Hypoxia 34.85 15.11 151 43834 47703 29860790
Inappropriate schedule of product administration 34.47 15.11 8 43977 39720 29868773
Tremor 34.30 15.11 36 43949 75327 29833166
Tracheal fistula 34.08 15.11 10 43975 74 29908419
Bradycardia 33.71 15.11 28 43957 65498 29842995
Electrocardiogram QT prolonged 33.62 15.11 6 43979 35829 29872664
Gastrointestinal toxicity 33.55 15.11 26 43959 1982 29906511
Condition aggravated 33.48 15.11 98 43887 137768 29770725
Gastritis bacterial 33.36 15.11 12 43973 179 29908314
Disseminated intravascular coagulation 33.09 15.11 89 43896 22082 29886411
Tidal volume decreased 31.37 15.11 8 43977 32 29908461
Colitis 31.24 15.11 108 43877 30712 29877781
Cardiac disorder 30.93 15.11 10 43975 39883 29868610
Neutropenic sepsis 30.80 15.11 58 43927 11351 29897142
Off label use 30.66 15.11 525 43460 248765 29659728
Therapy partial responder 30.25 15.11 32 43953 3659 29904834
Performance status decreased 30.13 15.11 33 43952 3924 29904569
Acute respiratory distress syndrome 29.93 15.11 89 43896 23383 29885110
Metastases to bone 29.76 15.11 52 43933 9606 29898887
Bronchospasm 29.72 15.11 54 43931 10284 29898209
Pleural effusion 29.47 15.11 198 43787 73868 29834625
Complication associated with device 29.29 15.11 39 43946 5681 29902812
Brain teratoma 29.00 15.11 7 43978 21 29908472
Injection site pain 28.60 15.11 5 43980 30305 29878188
Anaphylactic reaction 28.31 15.11 98 43887 27884 29880609
Incorrect dose administered 28.26 15.11 6 43979 31680 29876813
Rhabdomyolysis 28.23 15.11 31 43954 63549 29844944
Hypophagia 28.05 15.11 84 43901 22152 29886341
Musculoskeletal stiffness 27.81 15.11 9 43976 35872 29872621
Memory impairment 27.64 15.11 10 43975 37164 29871329
Periarticular thenar erythema with onycholysis 27.63 15.11 5 43980 0 29908493
Enterocolitis 27.43 15.11 41 43944 6646 29901847
Myocardial infarction 27.19 15.11 94 43891 125531 29782962
Septic shock 27.10 15.11 173 43812 63434 29845059
Therapeutic product effect decreased 26.99 15.11 5 43980 29071 29879422
Pneumatosis intestinalis 26.95 15.11 26 43959 2664 29905829
Pneumoperitoneum 26.89 15.11 21 43964 1619 29906874
Peripheral swelling 26.87 15.11 30 43955 61044 29847449
Radiation skin injury 26.44 15.11 15 43970 675 29907818
Metastatic gastric cancer 26.28 15.11 10 43975 176 29908317
Supraventricular tachycardia 26.23 15.11 51 43934 10221 29898272
Nephrolithiasis 25.96 15.11 3 43982 24807 29883686
Wrong technique in product usage process 25.63 15.11 7 43978 31148 29877345
Coma 25.19 15.11 14 43971 40435 29868058
Oesophageal pain 25.06 15.11 15 43970 747 29907746
Ileus 24.80 15.11 64 43921 15491 29893002
Tumour lysis syndrome 24.80 15.11 57 43928 12828 29895665
Agitation 24.41 15.11 26 43959 54047 29854446
Hyperkalaemia 24.34 15.11 37 43948 65973 29842520
Ductal adenocarcinoma of pancreas 24.32 15.11 7 43978 48 29908445
Influenza 24.29 15.11 17 43968 43381 29865112
Hypertransaminasaemia 23.86 15.11 29 43956 3856 29904637
Fluid retention 23.86 15.11 4 43981 24994 29883499
Stomatitis 22.95 15.11 112 43873 37167 29871326
Sense of oppression 22.84 15.11 12 43973 463 29908030
Chills 22.83 15.11 183 43802 72155 29836338
International normalised ratio increased 22.63 15.11 22 43963 47717 29860776
Lung adenocarcinoma 22.62 15.11 29 43956 4070 29904423
Abnormal behaviour 22.55 15.11 5 43980 25618 29882875
Gastric perforation 22.54 15.11 21 43964 2060 29906433
Prostate cancer 22.50 15.11 4 43981 23953 29884540
Tachycardia 22.44 15.11 185 43800 73554 29834939
Metastases to skin 22.35 15.11 11 43974 369 29908124
Muscle spasms 22.35 15.11 38 43947 64800 29843693
Blood glucose increased 22.20 15.11 35 43950 61495 29846998
Cytomegalovirus infection 22.13 15.11 4 43981 23670 29884823
Myocardial oedema 21.99 15.11 7 43978 70 29908423
Coronary artery aneurysm 21.82 15.11 7 43978 72 29908421
Urticaria 21.72 15.11 29 43956 54577 29853916
Taeniasis 21.48 15.11 7 43978 76 29908417
Irritability 21.32 15.11 4 43981 23046 29885447
Neutropenic colitis 21.30 15.11 21 43964 2209 29906284
Angioedema 21.27 15.11 12 43973 34372 29874121
Macular oedema 21.14 15.11 23 43962 2715 29905778
Portal venous gas 21.05 15.11 10 43975 310 29908183
Blood creatine phosphokinase increased 21.03 15.11 20 43965 43828 29864665
Chronic kidney disease 20.94 15.11 15 43970 37823 29870670
Feeling hot 20.92 15.11 60 43925 15444 29893049
Lactic acidosis 20.63 15.11 10 43975 31203 29877290
Immune-mediated enterocolitis 20.50 15.11 15 43970 1048 29907445
Asthma 20.47 15.11 14 43971 36160 29872333
Disturbance in attention 20.13 15.11 4 43981 22125 29886368
Lung neoplasm malignant 19.88 15.11 58 43927 15074 29893419
Dermatitis acneiform 19.34 15.11 32 43953 5657 29902836
Enterocolitis infectious 19.18 15.11 15 43970 1159 29907334
Infectious pleural effusion 19.18 15.11 19 43966 2011 29906482
Metastases to the mediastinum 19.17 15.11 8 43977 181 29908312
Adenocarcinoma pancreas 19.11 15.11 16 43969 1362 29907131
Arthralgia 19.05 15.11 119 43866 135672 29772821
Gait disturbance 18.98 15.11 52 43933 74725 29833768
Extravasation 18.94 15.11 18 43967 1810 29906683
Thrombocytosis 18.61 15.11 24 43961 3389 29905104
Anaphylactoid shock 18.52 15.11 10 43975 408 29908085
Dysarthria 18.35 15.11 11 43974 30479 29878014
Eosinophilia 18.19 15.11 5 43980 22155 29886338
Subdural haematoma 18.18 15.11 3 43982 18969 29889524
Acute kidney injury 18.14 15.11 288 43697 273554 29634939
Colorectal cancer stage III 18.06 15.11 4 43981 7 29908486
Vascular pseudoaneurysm ruptured 17.87 15.11 6 43979 72 29908421
Respiratory failure 17.85 15.11 226 43759 100416 29808077
Eastern Cooperative Oncology Group performance status worsened 17.75 15.11 10 43975 444 29908049
Herpes zoster 17.74 15.11 11 43974 29932 29878561
Lung disorder 17.58 15.11 92 43893 31377 29877116
Arterial rupture 17.50 15.11 10 43975 456 29908037
Odynophagia 17.49 15.11 27 43958 4500 29903993
Sinusitis 17.45 15.11 14 43971 33331 29875162
Metastases to peritoneum 17.42 15.11 16 43969 1541 29906952
Psychotic disorder 17.39 15.11 5 43980 21510 29886983
Pericardial effusion 17.16 15.11 69 43916 21075 29887418
Feeling abnormal 17.15 15.11 36 43949 56720 29851773
Gastric cancer 17.03 15.11 28 43957 4922 29903571
Failure to thrive 17.03 15.11 37 43948 8017 29900476
Metabolic acidosis 16.92 15.11 18 43967 37443 29871050
Transient ischaemic attack 16.76 15.11 8 43977 25192 29883301
Blastic plasmacytoid dendritic cell neoplasia 16.71 15.11 6 43979 89 29908404
Tumour marker increased 16.51 15.11 10 43975 509 29907984
Skin toxicity 16.40 15.11 22 43963 3227 29905266
Blister 16.36 15.11 5 43980 20678 29887815
Blood pressure increased 16.11 15.11 53 43932 71875 29836618
Dizziness 16.10 15.11 196 43789 194713 29713780
Hyponatraemia 16.05 15.11 160 43825 67042 29841451
Balance disorder 15.97 15.11 18 43967 36475 29872018
Cyanosis 15.92 15.11 46 43939 11889 29896604
Product quality issue 15.85 15.11 4 43981 18770 29889723
Arthritis 15.85 15.11 8 43977 24393 29884100
Nail disorder 15.72 15.11 16 43969 1749 29906744
Depressed mood 15.65 15.11 3 43982 17026 29891467
Osteosarcoma 15.63 15.11 7 43978 189 29908304
Nasal congestion 15.59 15.11 4 43981 18562 29889931
Seizure 15.57 15.11 83 43902 98392 29810101
Pulmonary hypoplasia 15.53 15.11 9 43976 422 29908071
Oesophageal fistula 15.36 15.11 7 43978 197 29908296
Treatment noncompliance 15.35 15.11 9 43976 25244 29883249
Metastatic malignant melanoma 15.31 15.11 17 43968 2053 29906440
Abdominal pain 15.30 15.11 282 43703 135372 29773121
Hiccups 15.23 15.11 39 43946 9395 29899098

Pharmacologic Action:

SourceCodeDescription
ATC L01CD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Taxanes
FDA PE N0000175085 Microtubule Inhibition
FDA EPC N0000175592 Microtubule Inhibitor
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D050257 Tubulin Modulators
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:61950 microtubule-stabilizing agent
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Hypertensive disorder indication 38341003 DOID:10763
Open-angle glaucoma indication 84494001 DOID:1067
Secondary malignant neoplasm of pancreas indication 94459006
Kaposi's sarcoma indication 109385007
Non-small cell lung cancer indication 254637007 DOID:3908
Carcinoma of breast indication 254838004 DOID:3459
Carcinoma of fallopian tube indication 276870001 DOID:1963
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of peritoneum indication 363492001
Metastatic Breast Carcinoma indication
Malignant glaucoma off-label use 10100008
Aphakic glaucoma off-label use 15374009
Secondary glaucoma off-label use 95717004
Neoplasm of esophagus off-label use 126817006 DOID:5041
Small cell carcinoma of lung off-label use 254632001 DOID:5409
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Malignant tumor of cervix off-label use 363354003 DOID:4362
Malignant tumor of testis off-label use 363449006 DOID:2998
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hyperbilirubinemia contraindication 14783006 DOID:2741
Myocardial infarction contraindication 22298006 DOID:5844
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Depressive disorder contraindication 35489007
Anaphylaxis contraindication 39579001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Sinus bradycardia contraindication 49710005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Liver function tests abnormal contraindication 166603001
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.47 acidic
pKa2 12.08 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
100MG/VIAL ABRAXANE ABRAXIS BIOSCIENCE N021660 Jan. 7, 2005 RX FOR SUSPENSION IV (INFUSION) March 6, 2021 PEDIATRIC EXCLUSIVITY
100MG/VIAL ABRAXANE ABRAXIS BIOSCIENCE N021660 Jan. 7, 2005 RX FOR SUSPENSION IV (INFUSION) Dec. 6, 2022 ADDITIONULLL CLINICAL TRIAL INFORMATION ADDED TO PEDIATRIC USE SUBSECTION
100MG/VIAL ABRAXANE ABRAXIS BIOSCIENCE N021660 Jan. 7, 2005 RX FOR SUSPENSION IV (INFUSION) June 6, 2023 PEDIATRIC EXCLUSIVITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin beta Tumour-associated antigen INHIBITOR EC50 8.05 IUPHAR SCIENTIFIC LITERATURE
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 5.30 IUPHAR
Delta-type opioid receptor GPCR Ki 5.83 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 4.62 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 4.95 DRUG MATRIX
Cholecystokinin receptor type A GPCR Ki 5.64 DRUG MATRIX
Substance-K receptor GPCR Ki 5.69 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 4.79 DRUG MATRIX
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Bile salt export pump Transporter WOMBAT-PK
Tubulin beta chain Structural INHIBITOR EC50 8.05 IUPHAR
Multidrug resistance protein 1 Transporter IC50 5.59 CHEMBL
Tubulin beta-3 chain Structural IC50 8.11 CHEMBL
Botulinum neurotoxin type A Enzyme IC50 5.28 CHEMBL

External reference:

IDSource
4020736 VUID
N0000148314 NUI
D00491 KEGG_DRUG
4020736 VANDF
C1961039 UMLSCUI
CHEBI:45863 CHEBI
TA1 PDB_CHEM_ID
CHEMBL428647 ChEMBL_ID
12079629 PUBCHEM_CID
D000068196 MESH_DESCRIPTOR_UI
D017239 MESH_DESCRIPTOR_UI
DB01229 DRUGBANK_ID
2770 IUPHAR_LIGAND_ID
7052 INN_ID
P88XT4IS4D UNII
196466 RXNORM
2296 MMSL
42243 MMSL
5224 MMSL
64289 MMSL
d01376 MMSL
004116 NDDF
387374002 SNOMEDCT_US
67735003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3213 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3213 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3216 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3216 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3217 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3218 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-3218 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-4764 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 0703-4768 INJECTION, SOLUTION, CONCENTRATE 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel Human Prescription Drug Label 1 16714-137 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 44567-504 INJECTION 6 mg INTRAVENOUS NDA 22 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 44567-505 INJECTION 6 mg INTRAVENOUS NDA 22 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 44567-506 INJECTION 6 mg INTRAVENOUS NDA 22 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 45963-613 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 45963-613 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 47781-593 INJECTION, SOLUTION 30 mg INTRAVENOUS ANDA 24 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 47781-594 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 24 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 47781-595 INJECTION, SOLUTION 300 mg INTRAVENOUS ANDA 24 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 61703-342 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 16 sections
Paclitaxel Human Prescription Drug Label 1 63323-763 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 68083-178 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 68083-179 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
PACLITAXELPACLITAXEL Human Prescription Drug Label 1 68083-180 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 19 sections
ABRAXANE HUMAN PRESCRIPTION DRUG LABEL 1 68817-134 INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 100 mg INTRAVENOUS NDA 32 sections
Paclitaxel Human Prescription Drug Label 1 69539-157 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 69539-158 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel Human Prescription Drug Label 1 69539-159 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 21 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 70860-200 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections
Paclitaxel HUMAN PRESCRIPTION DRUG LABEL 1 70860-215 INJECTION, SOLUTION 6 mg INTRAVENOUS ANDA 24 sections