Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastics, taxane derivatives | 2044 | 33069-62-4 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.54 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 6.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 6.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 10, 2019 | EMA | TEVA BV | |
Sept. 20, 2019 | PMDA | Taiho Pharmaceutical Co., Ltd. | |
Dec. 29, 1992 | FDA | HQ SPCLT PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1910.19 | 12.84 | 1556 | 144032 | 72031 | 56074448 |
Neutropenia | 1706.59 | 12.84 | 2071 | 143517 | 156096 | 55990383 |
Neuropathy peripheral | 1648.03 | 12.84 | 1658 | 143930 | 101235 | 56045244 |
Disease progression | 1223.19 | 12.84 | 1432 | 144156 | 103741 | 56042738 |
Metastases to liver | 1107.20 | 12.84 | 692 | 144896 | 20894 | 56125585 |
Erythema | 1039.61 | 12.84 | 1619 | 143969 | 154320 | 55992159 |
Metastases to bone | 1034.97 | 12.84 | 639 | 144949 | 18869 | 56127610 |
Febrile neutropenia | 1018.16 | 12.84 | 1308 | 144280 | 104237 | 56042242 |
Rheumatoid arthritis | 894.74 | 12.84 | 20 | 145568 | 382584 | 55763895 |
Flushing | 879.25 | 12.84 | 993 | 144595 | 69107 | 56077372 |
Breast cancer metastatic | 857.05 | 12.84 | 521 | 145067 | 14948 | 56131531 |
Anaemia | 826.17 | 12.84 | 2005 | 143583 | 265506 | 55880973 |
Myelosuppression | 709.97 | 12.84 | 484 | 145104 | 16971 | 56129508 |
Drug ineffective | 697.96 | 12.84 | 815 | 144773 | 918174 | 55228305 |
Metastases to lung | 665.41 | 12.84 | 401 | 145187 | 11317 | 56135162 |
Neutrophil count decreased | 662.71 | 12.84 | 728 | 144860 | 49094 | 56097385 |
Palmar-plantar erythrodysaesthesia syndrome | 656.90 | 12.84 | 497 | 145091 | 20568 | 56125911 |
Dyspnoea | 651.63 | 12.84 | 3137 | 142451 | 589440 | 55557039 |
Polyneuropathy | 566.94 | 12.84 | 377 | 145211 | 12673 | 56133806 |
Neoplasm progression | 557.96 | 12.84 | 541 | 145047 | 31475 | 56115004 |
Joint swelling | 549.90 | 12.84 | 56 | 145532 | 289744 | 55856735 |
Peripheral sensory neuropathy | 531.68 | 12.84 | 289 | 145299 | 6667 | 56139812 |
Acute myeloid leukaemia | 495.30 | 12.84 | 385 | 145203 | 16587 | 56129892 |
Metastases to central nervous system | 487.52 | 12.84 | 334 | 145254 | 11802 | 56134677 |
Thrombocytopenia | 477.21 | 12.84 | 1074 | 144514 | 135150 | 56011329 |
Leukopenia | 446.10 | 12.84 | 718 | 144870 | 70222 | 56076257 |
Metastases to lymph nodes | 444.76 | 12.84 | 263 | 145325 | 7160 | 56139319 |
Neurotoxicity | 442.98 | 12.84 | 350 | 145238 | 15445 | 56131034 |
Mucosal inflammation | 441.38 | 12.84 | 549 | 145039 | 42261 | 56104218 |
Contraindicated product administered | 412.06 | 12.84 | 16 | 145572 | 186270 | 55960209 |
Ejection fraction decreased | 404.72 | 12.84 | 366 | 145222 | 19475 | 56127004 |
Arthropathy | 403.33 | 12.84 | 30 | 145558 | 200245 | 55946234 |
Chest discomfort | 395.91 | 12.84 | 823 | 144765 | 98034 | 56048445 |
Death | 395.58 | 12.84 | 1838 | 143750 | 339588 | 55806891 |
Pneumonitis | 393.43 | 12.84 | 446 | 145142 | 31118 | 56115361 |
Product dose omission issue | 381.93 | 12.84 | 42 | 145546 | 204711 | 55941768 |
Systemic lupus erythematosus | 380.34 | 12.84 | 21 | 145567 | 180057 | 55966422 |
Haematotoxicity | 378.23 | 12.84 | 248 | 145340 | 8135 | 56138344 |
Synovitis | 374.23 | 12.84 | 9 | 145579 | 161296 | 55985183 |
Ascites | 364.04 | 12.84 | 467 | 145121 | 37077 | 56109402 |
Therapeutic product effect decreased | 348.06 | 12.84 | 23 | 145565 | 169429 | 55977050 |
Glossodynia | 344.44 | 12.84 | 11 | 145577 | 152447 | 55994032 |
Fall | 338.84 | 12.84 | 258 | 145330 | 357252 | 55789227 |
Bone marrow failure | 331.17 | 12.84 | 387 | 145201 | 27899 | 56118580 |
Abdominal discomfort | 325.77 | 12.84 | 155 | 145433 | 277119 | 55869360 |
Sinusitis | 325.34 | 12.84 | 59 | 145529 | 197522 | 55948957 |
Completed suicide | 324.69 | 12.84 | 4 | 145584 | 133829 | 56012650 |
Anaphylactic shock | 308.72 | 12.84 | 329 | 145259 | 21411 | 56125068 |
Pain | 307.96 | 12.84 | 800 | 144788 | 662384 | 55484095 |
Swelling | 302.25 | 12.84 | 121 | 145467 | 239650 | 55906829 |
Condition aggravated | 299.48 | 12.84 | 271 | 145317 | 344627 | 55801852 |
Proteinuria | 293.15 | 12.84 | 290 | 145298 | 17280 | 56129199 |
Breast cancer | 288.94 | 12.84 | 481 | 145107 | 48352 | 56098127 |
Second primary malignancy | 286.18 | 12.84 | 199 | 145389 | 7203 | 56139276 |
Weight increased | 284.52 | 12.84 | 119 | 145469 | 229584 | 55916895 |
Pseudocirrhosis | 283.21 | 12.84 | 93 | 145495 | 548 | 56145931 |
Metastases to peritoneum | 281.34 | 12.84 | 143 | 145445 | 2861 | 56143618 |
Feeling hot | 277.80 | 12.84 | 434 | 145154 | 41353 | 56105126 |
Epistaxis | 276.45 | 12.84 | 565 | 145023 | 66458 | 56080021 |
Cystoid macular oedema | 272.33 | 12.84 | 114 | 145474 | 1427 | 56145052 |
Myelodysplastic syndrome | 272.26 | 12.84 | 270 | 145318 | 16136 | 56130343 |
Headache | 267.26 | 12.84 | 664 | 144924 | 558380 | 55588099 |
Musculoskeletal stiffness | 260.22 | 12.84 | 45 | 145543 | 155962 | 55990517 |
Bronchospasm | 256.56 | 12.84 | 256 | 145332 | 15413 | 56131066 |
Pleural effusion | 255.61 | 12.84 | 634 | 144954 | 84846 | 56061633 |
Product use issue | 254.61 | 12.84 | 82 | 145506 | 185959 | 55960520 |
Interstitial lung disease | 252.03 | 12.84 | 495 | 145093 | 56568 | 56089911 |
Drug intolerance | 234.62 | 12.84 | 204 | 145384 | 264614 | 55881865 |
Onycholysis | 233.28 | 12.84 | 99 | 145489 | 1285 | 56145194 |
Skin toxicity | 230.26 | 12.84 | 140 | 145448 | 4013 | 56142466 |
Hypertension | 226.52 | 12.84 | 1236 | 144352 | 243042 | 55903437 |
Gastrointestinal perforation | 222.73 | 12.84 | 125 | 145463 | 3074 | 56143405 |
Wound | 216.77 | 12.84 | 47 | 145541 | 138757 | 56007722 |
Ovarian cancer recurrent | 215.03 | 12.84 | 88 | 145500 | 1036 | 56145443 |
Back pain | 213.83 | 12.84 | 1191 | 144397 | 235979 | 55910500 |
General physical health deterioration | 211.72 | 12.84 | 936 | 144652 | 169074 | 55977405 |
Peripheral swelling | 211.32 | 12.84 | 178 | 145410 | 234548 | 55911931 |
Treatment failure | 204.98 | 12.84 | 92 | 145496 | 170300 | 55976179 |
Vomiting | 204.79 | 12.84 | 2076 | 143512 | 496152 | 55650327 |
Arthralgia | 197.56 | 12.84 | 653 | 144935 | 501016 | 55645463 |
Diarrhoea | 191.43 | 12.84 | 2502 | 143086 | 636005 | 55510474 |
Psoriasis | 189.02 | 12.84 | 13 | 145575 | 92679 | 56053800 |
Injection site pain | 188.35 | 12.84 | 37 | 145551 | 117081 | 56029398 |
Bone pain | 184.78 | 12.84 | 404 | 145184 | 49781 | 56096698 |
Hypertransaminasaemia | 183.02 | 12.84 | 127 | 145461 | 4580 | 56141899 |
Nausea | 182.08 | 12.84 | 2876 | 142712 | 761302 | 55385177 |
Pericarditis | 180.32 | 12.84 | 32 | 145556 | 108891 | 56037588 |
Nasopharyngitis | 174.96 | 12.84 | 188 | 145400 | 220771 | 55925708 |
Cardiotoxicity | 171.68 | 12.84 | 149 | 145439 | 7501 | 56138978 |
Helicobacter infection | 170.18 | 12.84 | 4 | 145584 | 73264 | 56073215 |
Platelet count decreased | 169.99 | 12.84 | 633 | 144955 | 105750 | 56040729 |
Embolism | 166.41 | 12.84 | 144 | 145444 | 7220 | 56139259 |
Ovarian cancer | 165.85 | 12.84 | 134 | 145454 | 6104 | 56140375 |
Cardiac dysfunction | 164.99 | 12.84 | 87 | 145501 | 1883 | 56144596 |
Abdominal pain | 162.13 | 12.84 | 1185 | 144403 | 257620 | 55888859 |
Sense of oppression | 161.74 | 12.84 | 69 | 145519 | 908 | 56145571 |
Pyrexia | 160.95 | 12.84 | 1722 | 143866 | 417051 | 55729428 |
Metastasis | 160.52 | 12.84 | 118 | 145470 | 4666 | 56141813 |
Hepatic enzyme increased | 160.37 | 12.84 | 125 | 145463 | 171259 | 55975220 |
Breast cancer recurrent | 158.57 | 12.84 | 110 | 145478 | 3965 | 56142514 |
PIK3CA-activated mutation | 156.42 | 12.84 | 67 | 145521 | 891 | 56145588 |
Drug abuse | 155.85 | 12.84 | 4 | 145584 | 67606 | 56078873 |
Pancreatic carcinoma metastatic | 154.70 | 12.84 | 87 | 145501 | 2148 | 56144331 |
Blood cholesterol increased | 154.58 | 12.84 | 8 | 145580 | 72571 | 56073908 |
Irritable bowel syndrome | 154.32 | 12.84 | 5 | 145583 | 68453 | 56078026 |
White blood cell count decreased | 153.99 | 12.84 | 690 | 144898 | 125300 | 56021179 |
Therapy partial responder | 151.67 | 12.84 | 140 | 145448 | 7645 | 56138834 |
Osteonecrosis of jaw | 151.66 | 12.84 | 293 | 145295 | 33065 | 56113414 |
Mobility decreased | 151.54 | 12.84 | 35 | 145553 | 98956 | 56047523 |
Duodenal ulcer perforation | 150.56 | 12.84 | 6 | 145582 | 68336 | 56078143 |
Maternal exposure during pregnancy | 150.34 | 12.84 | 161 | 145427 | 189392 | 55957087 |
Discomfort | 147.70 | 12.84 | 92 | 145496 | 141669 | 56004810 |
Hospitalisation | 145.95 | 12.84 | 13 | 145575 | 74987 | 56071492 |
Arthritis | 143.81 | 12.84 | 40 | 145548 | 99812 | 56046667 |
Migraine | 142.57 | 12.84 | 26 | 145562 | 86771 | 56059708 |
Lymphangiosis carcinomatosa | 142.44 | 12.84 | 68 | 145520 | 1181 | 56145298 |
Hypokalaemia | 141.85 | 12.84 | 551 | 145037 | 93886 | 56052593 |
Contusion | 141.37 | 12.84 | 78 | 145510 | 128352 | 56018127 |
Hypoxia | 140.68 | 12.84 | 380 | 145208 | 53517 | 56092962 |
Overdose | 140.59 | 12.84 | 49 | 145539 | 105781 | 56040698 |
Drug hypersensitivity | 139.71 | 12.84 | 316 | 145272 | 274889 | 55871590 |
Tachycardia | 139.39 | 12.84 | 593 | 144995 | 105283 | 56041196 |
Loss of personal independence in daily activities | 136.65 | 12.84 | 23 | 145565 | 81346 | 56065133 |
Somnolence | 136.15 | 12.84 | 133 | 145455 | 163280 | 55983199 |
Suicide attempt | 134.93 | 12.84 | 3 | 145585 | 57833 | 56088646 |
Injection site erythema | 134.33 | 12.84 | 20 | 145568 | 77428 | 56069051 |
Paraesthesia | 132.81 | 12.84 | 678 | 144910 | 129836 | 56016643 |
Fibromyalgia | 132.09 | 12.84 | 5 | 145583 | 59598 | 56086881 |
Depression | 130.94 | 12.84 | 164 | 145424 | 179953 | 55966526 |
Exposure during pregnancy | 129.36 | 12.84 | 98 | 145490 | 136244 | 56010235 |
Asthma | 129.26 | 12.84 | 65 | 145523 | 112705 | 56033774 |
Metastases to meninges | 127.07 | 12.84 | 77 | 145511 | 2193 | 56144286 |
Pulmonary embolism | 125.88 | 12.84 | 580 | 145008 | 106544 | 56039935 |
Oxygen saturation decreased | 125.04 | 12.84 | 469 | 145119 | 78598 | 56067881 |
Nail disorder | 123.02 | 12.84 | 150 | 145438 | 11301 | 56135178 |
Neutropenic sepsis | 122.85 | 12.84 | 173 | 145415 | 15012 | 56131467 |
Hepatic failure | 122.59 | 12.84 | 269 | 145319 | 33217 | 56113262 |
Left ventricular dysfunction | 121.60 | 12.84 | 147 | 145441 | 10976 | 56135503 |
Disease recurrence | 121.46 | 12.84 | 220 | 145368 | 23640 | 56122839 |
Dehydration | 119.43 | 12.84 | 761 | 144827 | 158064 | 55988415 |
Influenza | 116.77 | 12.84 | 50 | 145538 | 95211 | 56051268 |
Lower respiratory tract infection | 116.14 | 12.84 | 77 | 145511 | 114717 | 56031762 |
Nail discolouration | 115.41 | 12.84 | 75 | 145513 | 2421 | 56144058 |
Large intestine perforation | 115.32 | 12.84 | 121 | 145467 | 7730 | 56138749 |
Throat tightness | 112.02 | 12.84 | 205 | 145383 | 22202 | 56124277 |
Peripheral motor neuropathy | 111.89 | 12.84 | 62 | 145526 | 1486 | 56144993 |
Asthenia | 109.45 | 12.84 | 1361 | 144227 | 341612 | 55804867 |
Cyanosis | 108.93 | 12.84 | 167 | 145421 | 15643 | 56130836 |
Biliary tract infection | 108.89 | 12.84 | 45 | 145543 | 544 | 56145935 |
Decreased appetite | 108.85 | 12.84 | 952 | 144636 | 218279 | 55928200 |
Pneumocystis jirovecii pneumonia | 106.99 | 12.84 | 165 | 145423 | 15536 | 56130943 |
Nail toxicity | 105.35 | 12.84 | 38 | 145550 | 308 | 56146171 |
Blister | 104.91 | 12.84 | 77 | 145511 | 108810 | 56037669 |
Intestinal perforation | 104.10 | 12.84 | 135 | 145453 | 10824 | 56135655 |
Ileus | 101.85 | 12.84 | 151 | 145437 | 13731 | 56132748 |
Hepatic atrophy | 101.58 | 12.84 | 35 | 145553 | 244 | 56146235 |
Confusional state | 101.56 | 12.84 | 244 | 145344 | 207911 | 55938568 |
Injection site reaction | 101.54 | 12.84 | 10 | 145578 | 53237 | 56093242 |
Gastrointestinal toxicity | 101.54 | 12.84 | 101 | 145487 | 6055 | 56140424 |
Cholangitis | 100.31 | 12.84 | 91 | 145497 | 4858 | 56141621 |
Inappropriate schedule of product administration | 98.69 | 12.84 | 46 | 145542 | 83341 | 56063138 |
Toxicity to various agents | 98.28 | 12.84 | 278 | 145310 | 224286 | 55922193 |
Memory impairment | 97.53 | 12.84 | 51 | 145537 | 86506 | 56059973 |
Metastases to skin | 96.18 | 12.84 | 55 | 145533 | 1403 | 56145076 |
Pancytopenia | 95.95 | 12.84 | 469 | 145119 | 88246 | 56058233 |
Osteoarthritis | 95.48 | 12.84 | 44 | 145544 | 80252 | 56066227 |
Urogenital fistula | 95.07 | 12.84 | 31 | 145557 | 178 | 56146301 |
Injury | 93.93 | 12.84 | 20 | 145568 | 59831 | 56086648 |
Feeling abnormal | 93.60 | 12.84 | 125 | 145463 | 133477 | 56013002 |
Injection site swelling | 92.17 | 12.84 | 5 | 145583 | 43573 | 56102906 |
Insomnia | 91.93 | 12.84 | 227 | 145361 | 191633 | 55954846 |
Gait disturbance | 91.65 | 12.84 | 177 | 145411 | 163144 | 55983335 |
Injection site pruritus | 88.10 | 12.84 | 5 | 145583 | 41926 | 56104553 |
Cardiomyopathy | 88.01 | 12.84 | 154 | 145434 | 16104 | 56130375 |
Pancreatic carcinoma | 87.95 | 12.84 | 101 | 145487 | 7140 | 56139339 |
Intentional product misuse | 87.71 | 12.84 | 14 | 145574 | 51490 | 56094989 |
Tumour necrosis | 86.40 | 12.84 | 41 | 145547 | 702 | 56145777 |
Incorrect dose administered | 85.72 | 12.84 | 16 | 145572 | 52531 | 56093948 |
Metastases to pleura | 85.50 | 12.84 | 50 | 145538 | 1332 | 56145147 |
Laryngospasm | 85.37 | 12.84 | 66 | 145522 | 2818 | 56143661 |
Dysaesthesia | 84.05 | 12.84 | 76 | 145512 | 4040 | 56142439 |
Drug interaction | 83.66 | 12.84 | 271 | 145317 | 209484 | 55936995 |
Plasma cell myeloma | 83.34 | 12.84 | 11 | 145577 | 46635 | 56099844 |
Folliculitis | 83.01 | 12.84 | 20 | 145568 | 54959 | 56091520 |
Small intestinal obstruction | 82.93 | 12.84 | 153 | 145435 | 16672 | 56129807 |
Posterior reversible encephalopathy syndrome | 82.30 | 12.84 | 148 | 145440 | 15812 | 56130667 |
Subileus | 82.01 | 12.84 | 65 | 145523 | 2879 | 56143600 |
C-reactive protein abnormal | 81.86 | 12.84 | 3 | 145585 | 36806 | 56109673 |
Non-small cell lung cancer | 81.58 | 12.84 | 71 | 145517 | 3587 | 56142892 |
Muscle spasms | 80.49 | 12.84 | 145 | 145443 | 137226 | 56009253 |
Recall phenomenon | 79.91 | 12.84 | 36 | 145552 | 544 | 56145935 |
Metastatic neoplasm | 79.41 | 12.84 | 72 | 145516 | 3841 | 56142638 |
Tumour marker increased | 79.39 | 12.84 | 75 | 145513 | 4218 | 56142261 |
Metastases to spine | 79.02 | 12.84 | 64 | 145524 | 2925 | 56143554 |
Hydronephrosis | 78.81 | 12.84 | 108 | 145480 | 9134 | 56137345 |
Red blood cell sedimentation rate increased | 78.09 | 12.84 | 4 | 145584 | 36619 | 56109860 |
Suicidal ideation | 77.94 | 12.84 | 26 | 145562 | 57716 | 56088763 |
Tumour haemorrhage | 77.70 | 12.84 | 48 | 145540 | 1416 | 56145063 |
Malignant pleural effusion | 77.49 | 12.84 | 58 | 145530 | 2358 | 56144121 |
Triple negative breast cancer | 76.73 | 12.84 | 27 | 145561 | 202 | 56146277 |
Acute promyelocytic leukaemia | 74.70 | 12.84 | 40 | 145548 | 894 | 56145585 |
Osteoporosis | 74.65 | 12.84 | 21 | 145567 | 52031 | 56094448 |
Cardiac failure | 74.25 | 12.84 | 413 | 145175 | 81680 | 56064799 |
Anaphylactoid reaction | 74.09 | 12.84 | 66 | 145522 | 3440 | 56143039 |
Hepatic function abnormal | 72.17 | 12.84 | 225 | 145363 | 34333 | 56112146 |
Portal hypertension | 71.55 | 12.84 | 65 | 145523 | 3476 | 56143003 |
Anaphylactic reaction | 71.17 | 12.84 | 322 | 145266 | 58673 | 56087806 |
Computerised tomogram thorax abnormal | 69.87 | 12.84 | 45 | 145543 | 1430 | 56145049 |
Radiation pneumonitis | 69.48 | 12.84 | 45 | 145543 | 1444 | 56145035 |
Invasive ductal breast carcinoma | 69.43 | 12.84 | 87 | 145501 | 6739 | 56139740 |
Hypoglycaemia | 68.86 | 12.84 | 29 | 145559 | 55786 | 56090693 |
Fluid retention | 68.50 | 12.84 | 27 | 145561 | 54051 | 56092428 |
Carbohydrate antigen 15-3 increased | 68.29 | 12.84 | 42 | 145546 | 1229 | 56145250 |
Alveolitis | 68.07 | 12.84 | 56 | 145532 | 2617 | 56143862 |
Illness | 67.08 | 12.84 | 6 | 145582 | 34505 | 56111974 |
Bronchitis | 65.38 | 12.84 | 119 | 145469 | 112192 | 56034287 |
Adverse event | 64.82 | 12.84 | 31 | 145557 | 55345 | 56091134 |
Metastases to kidney | 64.69 | 12.84 | 23 | 145565 | 178 | 56146301 |
Pain in extremity | 64.59 | 12.84 | 477 | 145111 | 296954 | 55849525 |
Metastases to the mediastinum | 63.80 | 12.84 | 29 | 145559 | 448 | 56146031 |
Pneumothorax | 63.22 | 12.84 | 127 | 145461 | 14740 | 56131739 |
Bronchostenosis | 63.13 | 12.84 | 28 | 145560 | 407 | 56146072 |
Abortion spontaneous | 62.10 | 12.84 | 18 | 145570 | 43735 | 56102744 |
Therapeutic product effect incomplete | 62.03 | 12.84 | 112 | 145476 | 105919 | 56040560 |
Secondary cerebellar degeneration | 61.91 | 12.84 | 17 | 145571 | 47 | 56146432 |
Metastases to retroperitoneum | 61.37 | 12.84 | 21 | 145567 | 143 | 56146336 |
Sleep disorder | 61.17 | 12.84 | 51 | 145537 | 67612 | 56078867 |
Tumour lysis syndrome | 60.75 | 12.84 | 88 | 145500 | 7835 | 56138644 |
Urticaria | 60.41 | 12.84 | 183 | 145405 | 144493 | 56001986 |
Superior vena cava syndrome | 60.32 | 12.84 | 31 | 145557 | 635 | 56145844 |
Hypertensive crisis | 59.80 | 12.84 | 120 | 145468 | 13916 | 56132563 |
Performance status decreased | 59.44 | 12.84 | 57 | 145531 | 3266 | 56143213 |
Anxiety | 59.40 | 12.84 | 277 | 145311 | 192895 | 55953584 |
Palmar erythema | 58.84 | 12.84 | 42 | 145546 | 1585 | 56144894 |
Paronychia | 58.72 | 12.84 | 68 | 145520 | 4850 | 56141629 |
Lymphoedema | 58.63 | 12.84 | 101 | 145487 | 10429 | 56136050 |
Blood pressure fluctuation | 58.40 | 12.84 | 16 | 145572 | 40344 | 56106135 |
COVID-19 | 58.06 | 12.84 | 65 | 145523 | 74993 | 56071486 |
Colitis | 57.95 | 12.84 | 238 | 145350 | 41573 | 56104906 |
Atelectasis | 57.42 | 12.84 | 143 | 145445 | 19165 | 56127314 |
Thrombotic microangiopathy | 57.37 | 12.84 | 94 | 145494 | 9317 | 56137162 |
Surgery | 57.23 | 12.84 | 8 | 145580 | 32478 | 56114001 |
Carbohydrate antigen 125 increased | 57.10 | 12.84 | 50 | 145538 | 2547 | 56143932 |
Ear infection | 56.82 | 12.84 | 7 | 145581 | 31288 | 56115191 |
Small intestinal perforation | 56.70 | 12.84 | 38 | 145550 | 1293 | 56145186 |
Macular oedema | 56.66 | 12.84 | 59 | 145529 | 3735 | 56142744 |
Cataract | 56.54 | 12.84 | 31 | 145557 | 51216 | 56095263 |
Multiple sclerosis | 56.36 | 12.84 | 4 | 145584 | 27798 | 56118681 |
Pulmonary arterial hypertension | 56.17 | 12.84 | 3 | 145585 | 26500 | 56119979 |
Urinary tract obstruction | 55.70 | 12.84 | 43 | 145545 | 1832 | 56144647 |
Hyperaemia | 55.18 | 12.84 | 45 | 145543 | 2077 | 56144402 |
Acute interstitial pneumonitis | 54.65 | 12.84 | 29 | 145559 | 636 | 56145843 |
Recurrent cancer | 54.47 | 12.84 | 42 | 145546 | 1786 | 56144693 |
Hot flush | 54.10 | 12.84 | 252 | 145336 | 46474 | 56100005 |
Unevaluable event | 53.85 | 12.84 | 28 | 145560 | 47659 | 56098820 |
Sepsis | 53.42 | 12.84 | 575 | 145013 | 139265 | 56007214 |
Infusion related reaction | 53.32 | 12.84 | 797 | 144791 | 208134 | 55938345 |
Neoplasm recurrence | 53.29 | 12.84 | 47 | 145541 | 2417 | 56144062 |
Coronary artery disease | 53.28 | 12.84 | 8 | 145580 | 30788 | 56115691 |
Hepatic lesion | 52.77 | 12.84 | 60 | 145528 | 4195 | 56142284 |
Carcinoembryonic antigen increased | 52.37 | 12.84 | 39 | 145549 | 1573 | 56144906 |
Gastric disorder | 52.30 | 12.84 | 11 | 145577 | 33199 | 56113280 |
Pericardial effusion | 52.25 | 12.84 | 172 | 145416 | 27003 | 56119476 |
Type 2 diabetes mellitus | 52.20 | 12.84 | 28 | 145560 | 46834 | 56099645 |
Malignant ascites | 52.11 | 12.84 | 31 | 145557 | 853 | 56145626 |
Hepatitis B reactivation | 51.95 | 12.84 | 46 | 145542 | 2378 | 56144101 |
Adverse drug reaction | 51.93 | 12.84 | 55 | 145533 | 65077 | 56081402 |
Pregnancy | 51.90 | 12.84 | 11 | 145577 | 33022 | 56113457 |
Nephrolithiasis | 51.82 | 12.84 | 16 | 145572 | 37319 | 56109160 |
Hypersensitivity | 51.71 | 12.84 | 941 | 144647 | 255467 | 55891012 |
Bile duct stenosis | 51.17 | 12.84 | 34 | 145554 | 1140 | 56145339 |
Dizziness | 51.05 | 12.84 | 676 | 144912 | 375464 | 55771015 |
Device related infection | 50.91 | 12.84 | 148 | 145440 | 21732 | 56124747 |
Drug reaction with eosinophilia and systemic symptoms | 49.91 | 12.84 | 9 | 145579 | 30295 | 56116184 |
Wheezing | 49.73 | 12.84 | 73 | 145515 | 74953 | 56071526 |
Metastases to chest wall | 49.55 | 12.84 | 25 | 145563 | 492 | 56145987 |
Cholangitis sclerosing | 49.49 | 12.84 | 36 | 145552 | 1400 | 56145079 |
Nasal congestion | 49.11 | 12.84 | 44 | 145544 | 56326 | 56090153 |
Medication error | 49.09 | 12.84 | 24 | 145564 | 42311 | 56104168 |
Bone lesion | 48.65 | 12.84 | 65 | 145523 | 5365 | 56141114 |
Constipation | 48.32 | 12.84 | 762 | 144826 | 201181 | 55945298 |
Hallucination | 48.31 | 12.84 | 34 | 145554 | 49115 | 56097364 |
Coma | 47.98 | 12.84 | 50 | 145538 | 59605 | 56086874 |
Basal cell carcinoma | 47.40 | 12.84 | 5 | 145583 | 25216 | 56121263 |
Eczema asteatotic | 47.30 | 12.84 | 20 | 145568 | 257 | 56146222 |
Tumour associated fever | 47.30 | 12.84 | 20 | 145568 | 257 | 56146222 |
Hypomagnesaemia | 46.91 | 12.84 | 157 | 145431 | 24858 | 56121621 |
Biliary sepsis | 46.66 | 12.84 | 29 | 145559 | 865 | 56145614 |
Extravasation | 46.53 | 12.84 | 41 | 145547 | 2106 | 56144373 |
Metastases to pelvis | 46.50 | 12.84 | 22 | 145566 | 374 | 56146105 |
Drug dependence | 46.39 | 12.84 | 3 | 145585 | 22530 | 56123949 |
Irritability | 46.19 | 12.84 | 10 | 145578 | 29578 | 56116901 |
Hip arthroplasty | 46.16 | 12.84 | 21 | 145567 | 38602 | 56107877 |
Enterocolitis infectious | 46.16 | 12.84 | 36 | 145552 | 1557 | 56144922 |
Drug resistance | 45.93 | 12.84 | 137 | 145451 | 20405 | 56126074 |
Subclavian vein thrombosis | 45.86 | 12.84 | 38 | 145550 | 1794 | 56144685 |
Device related thrombosis | 45.76 | 12.84 | 36 | 145552 | 1577 | 56144902 |
Serotonin syndrome | 45.56 | 12.84 | 7 | 145581 | 26483 | 56119996 |
Capillary leak syndrome | 45.55 | 12.84 | 39 | 145549 | 1927 | 56144552 |
Aortitis | 45.42 | 12.84 | 30 | 145558 | 996 | 56145483 |
Toxic erythema of chemotherapy | 44.65 | 12.84 | 16 | 145572 | 127 | 56146352 |
Respiratory distress | 44.47 | 12.84 | 181 | 145407 | 31486 | 56114993 |
Intestinal obstruction | 44.25 | 12.84 | 166 | 145422 | 27805 | 56118674 |
Suffocation feeling | 44.23 | 12.84 | 32 | 145556 | 1234 | 56145245 |
Chronic obstructive pulmonary disease | 44.10 | 12.84 | 50 | 145538 | 57365 | 56089114 |
Hormone receptor positive breast cancer | 43.98 | 12.84 | 23 | 145565 | 489 | 56145990 |
Swollen tongue | 43.92 | 12.84 | 12 | 145576 | 30312 | 56116167 |
Malignant peritoneal neoplasm | 43.88 | 12.84 | 26 | 145562 | 710 | 56145769 |
Hyperpyrexia | 43.82 | 12.84 | 48 | 145540 | 3220 | 56143259 |
Type I hypersensitivity | 43.37 | 12.84 | 42 | 145546 | 2436 | 56144043 |
Wrong technique in product usage process | 43.23 | 12.84 | 52 | 145536 | 58116 | 56088363 |
Nervousness | 42.93 | 12.84 | 11 | 145577 | 29004 | 56117475 |
Dysgeusia | 42.57 | 12.84 | 214 | 145374 | 40701 | 56105778 |
Oesophagobronchial fistula | 42.50 | 12.84 | 12 | 145576 | 38 | 56146441 |
Road traffic accident | 42.47 | 12.84 | 10 | 145578 | 27917 | 56118562 |
Transaminases increased | 42.45 | 12.84 | 167 | 145421 | 28603 | 56117876 |
Gait inability | 42.34 | 12.84 | 28 | 145560 | 41790 | 56104689 |
Febrile infection | 41.80 | 12.84 | 32 | 145556 | 1346 | 56145133 |
Pleural neoplasm | 41.65 | 12.84 | 20 | 145568 | 352 | 56146127 |
Periodontitis | 41.62 | 12.84 | 46 | 145542 | 3117 | 56143362 |
Stress | 41.35 | 12.84 | 55 | 145533 | 58855 | 56087624 |
Endocarditis noninfective | 40.94 | 12.84 | 12 | 145576 | 45 | 56146434 |
Joint range of motion decreased | 40.78 | 12.84 | 8 | 145580 | 25357 | 56121122 |
Administration site extravasation | 40.55 | 12.84 | 25 | 145563 | 735 | 56145744 |
Prescribed overdose | 40.45 | 12.84 | 5 | 145583 | 22291 | 56124188 |
Acute myelomonocytic leukaemia | 40.39 | 12.84 | 16 | 145572 | 172 | 56146307 |
Rash pruritic | 40.18 | 12.84 | 46 | 145542 | 52548 | 56093931 |
Muscle spasticity | 40.10 | 12.84 | 3 | 145585 | 19957 | 56126522 |
Metastases to abdominal wall | 39.75 | 12.84 | 14 | 145574 | 105 | 56146374 |
Hypoalbuminaemia | 39.75 | 12.84 | 86 | 145502 | 10513 | 56135966 |
Disseminated intravascular coagulation | 39.72 | 12.84 | 119 | 145469 | 17766 | 56128713 |
Cerebrovascular accident | 39.71 | 12.84 | 128 | 145460 | 99142 | 56047337 |
Joint stiffness | 39.70 | 12.84 | 21 | 145567 | 35404 | 56111075 |
Lactic acidosis | 39.54 | 12.84 | 21 | 145567 | 35325 | 56111154 |
Dyskinesia | 39.46 | 12.84 | 13 | 145575 | 29095 | 56117384 |
Inflammation | 39.46 | 12.84 | 74 | 145514 | 68997 | 56077482 |
Lymphadenopathy mediastinal | 39.42 | 12.84 | 41 | 145547 | 2592 | 56143887 |
Metastases to breast | 39.37 | 12.84 | 18 | 145570 | 282 | 56146197 |
Lymphocele | 39.28 | 12.84 | 25 | 145563 | 778 | 56145701 |
Adenocarcinoma | 39.26 | 12.84 | 42 | 145546 | 2743 | 56143736 |
Immune-mediated enterocolitis | 39.17 | 12.84 | 31 | 145557 | 1370 | 56145109 |
Deep vein thrombosis | 39.01 | 12.84 | 336 | 145252 | 76641 | 56069838 |
Rhabdomyolysis | 38.82 | 12.84 | 29 | 145559 | 40629 | 56105850 |
Psychotic disorder | 38.79 | 12.84 | 7 | 145581 | 23551 | 56122928 |
Gastrooesophageal reflux disease | 38.67 | 12.84 | 100 | 145488 | 83157 | 56063322 |
Blood uric acid decreased | 38.31 | 12.84 | 24 | 145564 | 726 | 56145753 |
Limb injury | 38.04 | 12.84 | 6 | 145582 | 22264 | 56124215 |
Product prescribing error | 37.94 | 12.84 | 7 | 145581 | 23179 | 56123300 |
Pseudomembranous colitis | 37.82 | 12.84 | 42 | 145546 | 2861 | 56143618 |
Ill-defined disorder | 37.79 | 12.84 | 75 | 145513 | 68468 | 56078011 |
Hypocalcaemia | 37.73 | 12.84 | 161 | 145427 | 28599 | 56117880 |
Myocardial infarction | 37.67 | 12.84 | 119 | 145469 | 92751 | 56053728 |
Capillary permeability increased | 37.43 | 12.84 | 10 | 145578 | 24 | 56146455 |
Hypervolaemia | 37.33 | 12.84 | 11 | 145577 | 26447 | 56120032 |
Peritonitis | 37.12 | 12.84 | 109 | 145479 | 16093 | 56130386 |
Amnesia | 37.06 | 12.84 | 39 | 145549 | 46283 | 56100196 |
Impaired healing | 36.84 | 12.84 | 109 | 145479 | 86732 | 56059747 |
Cachexia | 36.60 | 12.84 | 54 | 145534 | 4888 | 56141591 |
Hypersensitivity pneumonitis | 36.58 | 12.84 | 38 | 145550 | 2399 | 56144080 |
Metastases to stomach | 36.54 | 12.84 | 15 | 145573 | 178 | 56146301 |
Stomatitis | 36.50 | 12.84 | 475 | 145113 | 120335 | 56026144 |
Diabetes mellitus | 36.24 | 12.84 | 50 | 145538 | 52685 | 56093794 |
Female genital tract fistula | 36.07 | 12.84 | 51 | 145537 | 4441 | 56142038 |
Chills | 36.02 | 12.84 | 415 | 145173 | 102189 | 56044290 |
Lymphadenopathy | 35.82 | 12.84 | 183 | 145405 | 35025 | 56111454 |
Metastases to soft tissue | 35.71 | 12.84 | 14 | 145574 | 146 | 56146333 |
Fistula | 35.70 | 12.84 | 74 | 145514 | 8781 | 56137698 |
Onychalgia | 35.59 | 12.84 | 24 | 145564 | 825 | 56145654 |
Hyperhidrosis | 35.50 | 12.84 | 386 | 145202 | 93702 | 56052777 |
Nail dystrophy | 35.41 | 12.84 | 25 | 145563 | 927 | 56145552 |
Foot deformity | 35.31 | 12.84 | 9 | 145579 | 23816 | 56122663 |
Anastomotic leak | 35.11 | 12.84 | 19 | 145569 | 434 | 56146045 |
Eye pain | 34.99 | 12.84 | 18 | 145570 | 30829 | 56115650 |
Radiation necrosis | 34.93 | 12.84 | 18 | 145570 | 371 | 56146108 |
Mental disorder | 34.83 | 12.84 | 9 | 145579 | 23595 | 56122884 |
Herpes zoster | 34.60 | 12.84 | 92 | 145496 | 75797 | 56070682 |
Oesophagitis | 34.56 | 12.84 | 97 | 145491 | 13960 | 56132519 |
Hypotension | 34.51 | 12.84 | 870 | 144718 | 249638 | 55896841 |
Cervix carcinoma | 34.41 | 12.84 | 40 | 145548 | 2865 | 56143614 |
Tumour embolism | 34.28 | 12.84 | 13 | 145575 | 123 | 56146356 |
International normalised ratio increased | 34.21 | 12.84 | 38 | 145550 | 44003 | 56102476 |
Treatment noncompliance | 34.18 | 12.84 | 21 | 145567 | 32602 | 56113877 |
Ovarian cancer metastatic | 34.04 | 12.84 | 24 | 145564 | 888 | 56145591 |
Renal disorder | 34.00 | 12.84 | 17 | 145571 | 29588 | 56116891 |
Crying | 33.97 | 12.84 | 7 | 145581 | 21433 | 56125046 |
Therapy interrupted | 33.78 | 12.84 | 12 | 145576 | 25613 | 56120866 |
Bradycardia | 33.77 | 12.84 | 78 | 145510 | 67426 | 56079053 |
Computerised tomogram thorax | 33.76 | 12.84 | 15 | 145573 | 219 | 56146260 |
Night sweats | 33.76 | 12.84 | 34 | 145554 | 41179 | 56105300 |
Gallbladder disorder | 33.72 | 12.84 | 3 | 145585 | 17331 | 56129148 |
Injection site haemorrhage | 33.66 | 12.84 | 8 | 145580 | 22193 | 56124286 |
Acute erythroid leukaemia | 33.61 | 12.84 | 11 | 145577 | 64 | 56146415 |
Pruritus | 33.39 | 12.84 | 597 | 144991 | 316026 | 55830453 |
Acne | 33.29 | 12.84 | 7 | 145581 | 21129 | 56125350 |
Bronchial fistula | 33.28 | 12.84 | 9 | 145579 | 23 | 56146456 |
Scleroderma-like reaction | 33.19 | 12.84 | 11 | 145577 | 67 | 56146412 |
Dyspnoea at rest | 33.18 | 12.84 | 45 | 145543 | 3768 | 56142711 |
Bursitis | 32.96 | 12.84 | 15 | 145573 | 27567 | 56118912 |
Dermatitis acneiform | 32.94 | 12.84 | 48 | 145540 | 4296 | 56142183 |
Neutropenic colitis | 32.87 | 12.84 | 38 | 145550 | 2705 | 56143774 |
Product administration error | 32.82 | 12.84 | 7 | 145581 | 20922 | 56125557 |
Congestive cardiomyopathy | 32.64 | 12.84 | 56 | 145532 | 5763 | 56140716 |
Radiation skin injury | 32.50 | 12.84 | 23 | 145565 | 856 | 56145623 |
Kidney infection | 32.36 | 12.84 | 7 | 145581 | 20718 | 56125761 |
Wound dehiscence | 32.14 | 12.84 | 49 | 145539 | 4566 | 56141913 |
Blood glucose increased | 32.11 | 12.84 | 94 | 145494 | 75057 | 56071422 |
Peritoneal disorder | 32.02 | 12.84 | 18 | 145570 | 444 | 56146035 |
Eosinophil percentage increased | 31.97 | 12.84 | 24 | 145564 | 980 | 56145499 |
Rectal perforation | 31.91 | 12.84 | 17 | 145571 | 376 | 56146103 |
Infusion related hypersensitivity reaction | 31.77 | 12.84 | 13 | 145575 | 153 | 56146326 |
Incorrect route of product administration | 31.72 | 12.84 | 8 | 145580 | 21321 | 56125158 |
Stress cardiomyopathy | 31.68 | 12.84 | 68 | 145520 | 8268 | 56138211 |
Invasive lobular breast carcinoma | 31.37 | 12.84 | 22 | 145566 | 807 | 56145672 |
Primary cardiac lymphoma | 31.08 | 12.84 | 9 | 145579 | 32 | 56146447 |
No adverse event | 30.96 | 12.84 | 29 | 145559 | 36345 | 56110134 |
Vaginal fistula | 30.96 | 12.84 | 17 | 145571 | 400 | 56146079 |
Head injury | 30.95 | 12.84 | 13 | 145575 | 25053 | 56121426 |
Pulse absent | 30.80 | 12.84 | 50 | 145538 | 4917 | 56141562 |
Immune-mediated hepatitis | 30.79 | 12.84 | 24 | 145564 | 1037 | 56145442 |
Full blood count abnormal | 30.68 | 12.84 | 15 | 145573 | 26447 | 56120032 |
Cardiac cirrhosis | 30.46 | 12.84 | 12 | 145576 | 127 | 56146352 |
Neutrophil count abnormal | 30.35 | 12.84 | 36 | 145552 | 2634 | 56143845 |
Blood bilirubin increased | 30.27 | 12.84 | 168 | 145420 | 33186 | 56113293 |
Choking sensation | 30.22 | 12.84 | 40 | 145548 | 3271 | 56143208 |
Tonsillar disorder | 30.22 | 12.84 | 24 | 145564 | 1066 | 56145413 |
Loss of consciousness | 30.18 | 12.84 | 423 | 145165 | 108926 | 56037553 |
Metastases to bladder | 30.01 | 12.84 | 13 | 145575 | 178 | 56146301 |
Disability | 29.99 | 12.84 | 3 | 145585 | 15777 | 56130702 |
Nightmare | 29.98 | 12.84 | 4 | 145584 | 16822 | 56129657 |
Joint dislocation | 29.97 | 12.84 | 3 | 145585 | 15770 | 56130709 |
Metastases to eye | 29.96 | 12.84 | 12 | 145576 | 133 | 56146346 |
Pneumonitis chemical | 29.81 | 12.84 | 13 | 145575 | 181 | 56146298 |
Panic attack | 29.78 | 12.84 | 8 | 145580 | 20439 | 56126040 |
Neuromuscular toxicity | 29.57 | 12.84 | 12 | 145576 | 138 | 56146341 |
Oropharyngeal pain | 29.51 | 12.84 | 114 | 145474 | 83674 | 56062805 |
Alanine aminotransferase increased | 29.45 | 12.84 | 371 | 145217 | 93291 | 56053188 |
Duodenitis haemorrhagic | 29.41 | 12.84 | 7 | 145581 | 8 | 56146471 |
Gastrointestinal necrosis | 29.18 | 12.84 | 35 | 145553 | 2591 | 56143888 |
Device dislocation | 29.10 | 12.84 | 11 | 145577 | 22595 | 56123884 |
Flatulence | 29.00 | 12.84 | 23 | 145565 | 31265 | 56115214 |
Eosinophilia | 28.97 | 12.84 | 8 | 145580 | 20069 | 56126410 |
Glaucoma | 28.86 | 12.84 | 5 | 145583 | 17324 | 56129155 |
Vena cava thrombosis | 28.81 | 12.84 | 31 | 145557 | 2038 | 56144441 |
Neoplasm | 28.81 | 12.84 | 56 | 145532 | 6345 | 56140134 |
HER2 positive breast cancer | 28.74 | 12.84 | 16 | 145572 | 387 | 56146092 |
Tumour pain | 28.67 | 12.84 | 25 | 145563 | 1266 | 56145213 |
Mastitis | 28.60 | 12.84 | 34 | 145554 | 2494 | 56143985 |
Upper limb fracture | 28.46 | 12.84 | 5 | 145583 | 17150 | 56129329 |
Pulmonary tumour thrombotic microangiopathy | 28.31 | 12.84 | 9 | 145579 | 47 | 56146432 |
Venous thrombosis | 28.26 | 12.84 | 46 | 145542 | 4534 | 56141945 |
Therapeutic response unexpected | 28.20 | 12.84 | 5 | 145583 | 17039 | 56129440 |
Metabolic acidosis | 28.16 | 12.84 | 38 | 145550 | 40416 | 56106063 |
Aggression | 27.84 | 12.84 | 11 | 145577 | 21995 | 56124484 |
Tremor | 27.78 | 12.84 | 191 | 145397 | 120898 | 56025581 |
Cough | 27.75 | 12.84 | 874 | 144714 | 259087 | 55887392 |
Cytopenia | 27.70 | 12.84 | 71 | 145517 | 9684 | 56136795 |
Gastrointestinal fistula | 27.67 | 12.84 | 16 | 145572 | 417 | 56146062 |
Guillain-Barre syndrome | 27.45 | 12.84 | 40 | 145548 | 3580 | 56142899 |
Skin laceration | 27.33 | 12.84 | 9 | 145579 | 20147 | 56126332 |
Cytomegalovirus infection | 27.27 | 12.84 | 8 | 145580 | 19288 | 56127191 |
Hypopituitarism | 27.15 | 12.84 | 22 | 145566 | 1006 | 56145473 |
Nasal septum perforation | 27.14 | 12.84 | 19 | 145569 | 695 | 56145784 |
Porokeratosis | 26.99 | 12.84 | 11 | 145577 | 128 | 56146351 |
Musculoskeletal disorder | 26.94 | 12.84 | 8 | 145580 | 19139 | 56127340 |
Bone marrow infiltration | 26.88 | 12.84 | 17 | 145571 | 523 | 56145956 |
Sinus disorder | 26.84 | 12.84 | 10 | 145578 | 20724 | 56125755 |
Prescribed underdose | 26.59 | 12.84 | 10 | 145578 | 20607 | 56125872 |
Acute megakaryocytic leukaemia | 26.50 | 12.84 | 8 | 145580 | 34 | 56146445 |
Protein urine | 26.38 | 12.84 | 18 | 145570 | 631 | 56145848 |
Neck pain | 26.29 | 12.84 | 77 | 145511 | 61478 | 56085001 |
Adrenocorticotropic hormone deficiency | 26.22 | 12.84 | 14 | 145574 | 311 | 56146168 |
Thyroid dermatopathy | 26.14 | 12.84 | 7 | 145581 | 17 | 56146462 |
Enterocolitis | 25.91 | 12.84 | 57 | 145531 | 7047 | 56139432 |
Immune-mediated myocarditis | 25.90 | 12.84 | 11 | 145577 | 143 | 56146336 |
Pelvic abscess | 25.86 | 12.84 | 25 | 145563 | 1447 | 56145032 |
Foot fracture | 25.84 | 12.84 | 12 | 145576 | 21797 | 56124682 |
Blood pressure systolic increased | 25.83 | 12.84 | 41 | 145547 | 40795 | 56105684 |
Scintillating scotoma | 25.77 | 12.84 | 11 | 145577 | 145 | 56146334 |
Laboratory test abnormal | 25.73 | 12.84 | 16 | 145572 | 24679 | 56121800 |
Bone erosion | 25.65 | 12.84 | 4 | 145584 | 14970 | 56131509 |
Double hit lymphoma | 25.62 | 12.84 | 6 | 145582 | 6 | 56146473 |
Fear | 25.50 | 12.84 | 4 | 145584 | 14904 | 56131575 |
Mood swings | 25.46 | 12.84 | 6 | 145582 | 16741 | 56129738 |
Viral infection | 25.44 | 12.84 | 27 | 145561 | 31919 | 56114560 |
Underdose | 25.30 | 12.84 | 15 | 145573 | 23742 | 56122737 |
Duodenal perforation | 25.22 | 12.84 | 19 | 145569 | 780 | 56145699 |
Vocal cord paralysis | 25.20 | 12.84 | 28 | 145560 | 1909 | 56144570 |
Drug level increased | 25.19 | 12.84 | 11 | 145577 | 20714 | 56125765 |
Upper respiratory tract infection | 25.10 | 12.84 | 97 | 145491 | 71191 | 56075288 |
Cervix carcinoma recurrent | 24.97 | 12.84 | 8 | 145580 | 43 | 56146436 |
Chest pain | 24.90 | 12.84 | 655 | 144933 | 189142 | 55957337 |
Portal vein thrombosis | 24.83 | 12.84 | 31 | 145557 | 2392 | 56144087 |
Carpal tunnel syndrome | 24.78 | 12.84 | 8 | 145580 | 18136 | 56128343 |
Impaired work ability | 24.72 | 12.84 | 4 | 145584 | 14568 | 56131911 |
Transfusion | 24.60 | 12.84 | 3 | 145585 | 13517 | 56132962 |
Osteolysis | 24.52 | 12.84 | 32 | 145556 | 2581 | 56143898 |
Tooth erosion | 24.48 | 12.84 | 15 | 145573 | 436 | 56146043 |
Acute pulmonary oedema | 24.44 | 12.84 | 58 | 145530 | 7539 | 56138940 |
Haemoglobin | 24.43 | 12.84 | 11 | 145577 | 166 | 56146313 |
Procedural pain | 24.40 | 12.84 | 6 | 145582 | 16265 | 56130214 |
Intestinal metastasis | 24.34 | 12.84 | 10 | 145578 | 119 | 56146360 |
Laryngeal discomfort | 24.30 | 12.84 | 13 | 145575 | 290 | 56146189 |
Gastroenteritis radiation | 24.30 | 12.84 | 15 | 145573 | 442 | 56146037 |
Accidental exposure to product | 24.28 | 12.84 | 17 | 145571 | 24630 | 56121849 |
Jugular vein thrombosis | 24.27 | 12.84 | 33 | 145555 | 2770 | 56143709 |
Sciatica | 24.26 | 12.84 | 19 | 145569 | 25991 | 56120488 |
Infection | 24.20 | 12.84 | 368 | 145220 | 199838 | 55946641 |
Device malfunction | 24.10 | 12.84 | 6 | 145582 | 16130 | 56130349 |
Oligoastrocytoma | 23.93 | 12.84 | 7 | 145581 | 26 | 56146453 |
Embryonal rhabdomyosarcoma | 23.90 | 12.84 | 6 | 145582 | 10 | 56146469 |
Hepatotoxicity | 23.81 | 12.84 | 150 | 145438 | 31003 | 56115476 |
Colitis ulcerative | 23.80 | 12.84 | 17 | 145571 | 24374 | 56122105 |
Adenocarcinoma pancreas | 23.79 | 12.84 | 21 | 145567 | 1081 | 56145398 |
Intracranial tumour haemorrhage | 23.68 | 12.84 | 11 | 145577 | 179 | 56146300 |
Blast cells present | 23.57 | 12.84 | 14 | 145574 | 384 | 56146095 |
Cholangitis infective | 23.56 | 12.84 | 12 | 145576 | 241 | 56146238 |
Spinal stenosis | 23.43 | 12.84 | 4 | 145584 | 14010 | 56132469 |
Exostosis | 23.43 | 12.84 | 5 | 145583 | 14938 | 56131541 |
Eastern Cooperative Oncology Group performance status worsened | 23.35 | 12.84 | 19 | 145569 | 874 | 56145605 |
Acute lymphocytic leukaemia | 23.29 | 12.84 | 32 | 145556 | 2712 | 56143767 |
Sinus congestion | 23.19 | 12.84 | 6 | 145582 | 15718 | 56130761 |
Emphysematous cystitis | 23.14 | 12.84 | 10 | 145578 | 136 | 56146343 |
Poisoning | 22.94 | 12.84 | 3 | 145585 | 12810 | 56133669 |
Product quality issue | 22.92 | 12.84 | 29 | 145559 | 31707 | 56114772 |
Blood potassium increased | 22.89 | 12.84 | 8 | 145580 | 17253 | 56129226 |
Lymphopenia | 22.86 | 12.84 | 95 | 145493 | 16679 | 56129800 |
Ankle fracture | 22.82 | 12.84 | 7 | 145581 | 16396 | 56130083 |
Obesity | 22.76 | 12.84 | 15 | 145573 | 22433 | 56124046 |
Right ventricular failure | 22.76 | 12.84 | 7 | 145581 | 16372 | 56130107 |
Pelvic pain | 22.71 | 12.84 | 75 | 145513 | 11792 | 56134687 |
Hypersomnia | 22.68 | 12.84 | 7 | 145581 | 16334 | 56130145 |
Cancer pain | 22.65 | 12.84 | 33 | 145555 | 2953 | 56143526 |
Laryngeal necrosis | 22.57 | 12.84 | 6 | 145582 | 14 | 56146465 |
Peritoneal fibrosis | 22.46 | 12.84 | 5 | 145583 | 3 | 56146476 |
Drug ineffective for unapproved indication | 22.44 | 12.84 | 20 | 145568 | 25673 | 56120806 |
Vesical fistula | 22.38 | 12.84 | 8 | 145580 | 63 | 56146416 |
Granulocyte count decreased | 22.20 | 12.84 | 19 | 145569 | 938 | 56145541 |
Balance disorder | 22.17 | 12.84 | 112 | 145476 | 76408 | 56070071 |
Infected lymphocele | 22.15 | 12.84 | 11 | 145577 | 209 | 56146270 |
Respiratory failure | 22.06 | 12.84 | 357 | 145231 | 94705 | 56051774 |
Angiosarcoma | 22.02 | 12.84 | 12 | 145576 | 278 | 56146201 |
Dystonia | 22.01 | 12.84 | 3 | 145585 | 12418 | 56134061 |
Organising pneumonia | 22.00 | 12.84 | 45 | 145543 | 5290 | 56141189 |
Transient ischaemic attack | 21.92 | 12.84 | 33 | 145555 | 33544 | 56112935 |
Cystitis noninfective | 21.91 | 12.84 | 19 | 145569 | 955 | 56145524 |
Bladder perforation | 21.85 | 12.84 | 10 | 145578 | 157 | 56146322 |
Haemolytic uraemic syndrome | 21.84 | 12.84 | 29 | 145559 | 2379 | 56144100 |
Hypermetabolism | 21.80 | 12.84 | 10 | 145578 | 158 | 56146321 |
Eye pruritus | 21.77 | 12.84 | 5 | 145583 | 14201 | 56132278 |
Accidental overdose | 21.67 | 12.84 | 13 | 145575 | 20448 | 56126031 |
Eye disorder | 21.66 | 12.84 | 13 | 145575 | 20439 | 56126040 |
Scleroderma | 21.60 | 12.84 | 43 | 145545 | 4958 | 56141521 |
Lymphatic disorder | 21.59 | 12.84 | 13 | 145575 | 366 | 56146113 |
Macular degeneration | 21.50 | 12.84 | 11 | 145577 | 18897 | 56127582 |
Arterioenteric fistula | 21.49 | 12.84 | 6 | 145582 | 18 | 56146461 |
Electrocardiogram QT prolonged | 21.40 | 12.84 | 71 | 145517 | 54517 | 56091962 |
Joint effusion | 21.38 | 12.84 | 6 | 145582 | 14892 | 56131587 |
Retroperitoneal neoplasm metastatic | 21.35 | 12.84 | 7 | 145581 | 41 | 56146438 |
Gelastic seizure | 21.35 | 12.84 | 5 | 145583 | 5 | 56146474 |
Abnormal behaviour | 21.31 | 12.84 | 13 | 145575 | 20259 | 56126220 |
Xerophthalmia | 21.21 | 12.84 | 14 | 145574 | 464 | 56146015 |
Metastases to ovary | 21.21 | 12.84 | 13 | 145575 | 378 | 56146101 |
Breast cellulitis | 21.13 | 12.84 | 15 | 145573 | 561 | 56145918 |
Wrist fracture | 21.09 | 12.84 | 3 | 145585 | 12023 | 56134456 |
Pancreatitis | 21.04 | 12.84 | 54 | 145534 | 45026 | 56101453 |
Ovarian cancer stage IV | 21.03 | 12.84 | 11 | 145577 | 234 | 56146245 |
Enteritis | 20.95 | 12.84 | 54 | 145534 | 7389 | 56139090 |
Cerebral ischaemia | 20.93 | 12.84 | 48 | 145540 | 6102 | 56140377 |
Seasonal allergy | 20.92 | 12.84 | 9 | 145579 | 17099 | 56129380 |
Septic shock | 20.87 | 12.84 | 245 | 145343 | 60590 | 56085889 |
Diverticulitis | 20.84 | 12.84 | 38 | 145550 | 35814 | 56110665 |
Femur fracture | 20.81 | 12.84 | 44 | 145544 | 39251 | 56107228 |
Pulmonary vein stenosis | 20.71 | 12.84 | 8 | 145580 | 80 | 56146399 |
Full blood count decreased | 20.61 | 12.84 | 18 | 145570 | 23331 | 56123148 |
Ocular hyperaemia | 20.57 | 12.84 | 16 | 145572 | 21963 | 56124516 |
Seroma | 20.47 | 12.84 | 25 | 145563 | 1886 | 56144593 |
BRAF gene mutation | 20.42 | 12.84 | 7 | 145581 | 48 | 56146431 |
Transaminases | 20.36 | 12.84 | 8 | 145580 | 84 | 56146395 |
Hepatic vein thrombosis | 20.34 | 12.84 | 9 | 145579 | 130 | 56146349 |
Blood iron decreased | 20.26 | 12.84 | 4 | 145584 | 12623 | 56133856 |
Lymphangitis | 20.25 | 12.84 | 17 | 145571 | 817 | 56145662 |
Blood alkaline phosphatase increased | 20.25 | 12.84 | 171 | 145417 | 38774 | 56107705 |
Vessel puncture site bruise | 20.19 | 12.84 | 13 | 145575 | 413 | 56146066 |
Splenic artery thrombosis | 20.17 | 12.84 | 7 | 145581 | 50 | 56146429 |
Hallucination, visual | 20.10 | 12.84 | 10 | 145578 | 17458 | 56129021 |
Type 1 lepra reaction | 20.04 | 12.84 | 5 | 145583 | 8 | 56146471 |
Abdominal infection | 20.01 | 12.84 | 24 | 145564 | 1777 | 56144702 |
Pulmonary toxicity | 19.97 | 12.84 | 55 | 145533 | 7828 | 56138651 |
Enterocutaneous fistula | 19.88 | 12.84 | 20 | 145568 | 1215 | 56145264 |
Sopor | 19.87 | 12.84 | 15 | 145573 | 20907 | 56125572 |
Bacterial parotitis | 19.84 | 12.84 | 4 | 145584 | 0 | 56146479 |
Venous thrombosis limb | 19.81 | 12.84 | 30 | 145558 | 2779 | 56143700 |
Brachiocephalic vein thrombosis | 19.71 | 12.84 | 8 | 145580 | 92 | 56146387 |
Tumour ulceration | 19.69 | 12.84 | 9 | 145579 | 141 | 56146338 |
Emotional disorder | 19.51 | 12.84 | 4 | 145584 | 12291 | 56134188 |
Retroperitoneal lymphadenopathy | 19.51 | 12.84 | 14 | 145574 | 533 | 56145946 |
Radiation oesophagitis | 19.47 | 12.84 | 11 | 145577 | 274 | 56146205 |
TP53 gene mutation | 19.43 | 12.84 | 6 | 145582 | 28 | 56146451 |
Pneumonia | 19.40 | 12.84 | 858 | 144730 | 406240 | 55740239 |
Respiratory tract congestion | 19.39 | 12.84 | 8 | 145580 | 15583 | 56130896 |
Immune-mediated hepatic disorder | 19.33 | 12.84 | 11 | 145577 | 278 | 56146201 |
Respiratory depth decreased | 19.25 | 12.84 | 6 | 145582 | 29 | 56146450 |
Duodenal obstruction | 19.23 | 12.84 | 10 | 145578 | 210 | 56146269 |
Poor quality sleep | 19.21 | 12.84 | 11 | 145577 | 17744 | 56128735 |
Intestinal ischaemia | 19.11 | 12.84 | 50 | 145538 | 6905 | 56139574 |
Dermatomyositis | 19.10 | 12.84 | 29 | 145559 | 2693 | 56143786 |
Neuroendocrine breast tumour | 19.09 | 12.84 | 6 | 145582 | 30 | 56146449 |
Rash | 19.06 | 12.84 | 1062 | 144526 | 491985 | 55654494 |
Delirium | 19.03 | 12.84 | 52 | 145536 | 42465 | 56104014 |
Blood glucose decreased | 19.02 | 12.84 | 13 | 145575 | 19074 | 56127405 |
Influenza like illness | 18.99 | 12.84 | 87 | 145501 | 60901 | 56085578 |
Breast ulceration | 18.96 | 12.84 | 7 | 145581 | 61 | 56146418 |
Device issue | 18.96 | 12.84 | 16 | 145572 | 21090 | 56125389 |
Eye irritation | 18.91 | 12.84 | 13 | 145575 | 19015 | 56127464 |
Pelvic infection | 18.91 | 12.84 | 11 | 145577 | 290 | 56146189 |
Metastases to thorax | 18.90 | 12.84 | 10 | 145578 | 218 | 56146261 |
Erythema multiforme | 18.84 | 12.84 | 61 | 145527 | 9493 | 56136986 |
Emotional distress | 18.72 | 12.84 | 30 | 145558 | 29733 | 56116746 |
Endometrial cancer recurrent | 18.71 | 12.84 | 5 | 145583 | 12 | 56146467 |
Post procedural fistula | 18.65 | 12.84 | 10 | 145578 | 224 | 56146255 |
Ear pain | 18.62 | 12.84 | 32 | 145556 | 30858 | 56115621 |
Cholangitis acute | 18.61 | 12.84 | 13 | 145575 | 474 | 56146005 |
Myoclonus | 18.59 | 12.84 | 8 | 145580 | 15195 | 56131284 |
Electrolyte imbalance | 18.53 | 12.84 | 94 | 145494 | 17939 | 56128540 |
Hydrothorax | 18.52 | 12.84 | 16 | 145572 | 800 | 56145679 |
Clonal haematopoiesis | 18.43 | 12.84 | 5 | 145583 | 13 | 56146466 |
Ovarian clear cell carcinoma | 18.43 | 12.84 | 5 | 145583 | 13 | 56146466 |
Laryngeal cancer stage III | 18.43 | 12.84 | 5 | 145583 | 13 | 56146466 |
Cardiovascular disorder | 18.38 | 12.84 | 66 | 145522 | 10823 | 56135656 |
Metastases to pancreas | 18.38 | 12.84 | 10 | 145578 | 231 | 56146248 |
Abdominal lymphadenopathy | 18.34 | 12.84 | 15 | 145573 | 695 | 56145784 |
Fungal infection | 18.27 | 12.84 | 36 | 145552 | 32957 | 56113522 |
Eye swelling | 18.24 | 12.84 | 17 | 145571 | 21359 | 56125120 |
Aorto-oesophageal fistula | 18.16 | 12.84 | 5 | 145583 | 14 | 56146465 |
Breast neoplasm | 18.09 | 12.84 | 20 | 145568 | 1356 | 56145123 |
Metastases to adrenals | 18.09 | 12.84 | 15 | 145573 | 709 | 56145770 |
Dementia | 18.04 | 12.84 | 11 | 145577 | 17147 | 56129332 |
Aplasia | 18.03 | 12.84 | 35 | 145553 | 3961 | 56142518 |
Ovarian epithelial cancer | 18.00 | 12.84 | 11 | 145577 | 318 | 56146161 |
Blood pressure diastolic abnormal | 17.94 | 12.84 | 4 | 145584 | 11594 | 56134885 |
Thrombophlebitis migrans | 17.87 | 12.84 | 8 | 145580 | 119 | 56146360 |
Neutropenic infection | 17.85 | 12.84 | 18 | 145570 | 1097 | 56145382 |
Cancer fatigue | 17.77 | 12.84 | 7 | 145581 | 74 | 56146405 |
Angiodermatitis | 17.77 | 12.84 | 7 | 145581 | 74 | 56146405 |
Glomerular vascular disorder | 17.77 | 12.84 | 6 | 145582 | 39 | 56146440 |
Gastroenteritis viral | 17.72 | 12.84 | 16 | 145572 | 20408 | 56126071 |
Cranial nerve disorder | 17.70 | 12.84 | 13 | 145575 | 513 | 56145966 |
Vaginal perforation | 17.67 | 12.84 | 5 | 145583 | 16 | 56146463 |
Liver scan abnormal | 17.64 | 12.84 | 6 | 145582 | 40 | 56146439 |
Therapy cessation | 17.60 | 12.84 | 27 | 145561 | 27237 | 56119242 |
Blood pressure immeasurable | 17.58 | 12.84 | 18 | 145570 | 1117 | 56145362 |
Blood magnesium decreased | 17.57 | 12.84 | 69 | 145519 | 11805 | 56134674 |
Hyponatraemia | 17.54 | 12.84 | 366 | 145222 | 101773 | 56044706 |
Acute monocytic leukaemia | 17.52 | 12.84 | 8 | 145580 | 125 | 56146354 |
Cardiac murmur | 17.50 | 12.84 | 4 | 145584 | 11397 | 56135082 |
Gastric perforation | 17.48 | 12.84 | 21 | 145567 | 1557 | 56144922 |
Live birth | 17.44 | 12.84 | 15 | 145573 | 19590 | 56126889 |
Vulvovaginal inflammation | 17.40 | 12.84 | 15 | 145573 | 748 | 56145731 |
Gout | 17.39 | 12.84 | 5 | 145583 | 12216 | 56134263 |
Acquired gene mutation | 17.37 | 12.84 | 16 | 145572 | 871 | 56145608 |
Endometrial cancer metastatic | 17.29 | 12.84 | 8 | 145580 | 129 | 56146350 |
Photophobia | 17.28 | 12.84 | 10 | 145578 | 16040 | 56130439 |
Intestinal prolapse | 17.24 | 12.84 | 8 | 145580 | 130 | 56146349 |
Blood creatinine decreased | 17.23 | 12.84 | 40 | 145548 | 5126 | 56141353 |
Mediastinitis | 17.14 | 12.84 | 9 | 145579 | 193 | 56146286 |
Nail ridging | 17.09 | 12.84 | 11 | 145577 | 349 | 56146130 |
Breast sarcoma | 17.08 | 12.84 | 4 | 145584 | 4 | 56146475 |
Tumour cavitation | 17.08 | 12.84 | 4 | 145584 | 4 | 56146475 |
Aortic dissection rupture | 17.08 | 12.84 | 4 | 145584 | 4 | 56146475 |
Maternal death affecting foetus | 17.08 | 12.84 | 4 | 145584 | 4 | 56146475 |
Sensory disturbance | 17.06 | 12.84 | 71 | 145517 | 12472 | 56134007 |
Lymphatic obstruction | 17.01 | 12.84 | 5 | 145583 | 19 | 56146460 |
Metastases to muscle | 16.96 | 12.84 | 8 | 145580 | 135 | 56146344 |
Anaemia of malignant disease | 16.90 | 12.84 | 12 | 145576 | 449 | 56146030 |
Mediastinal disorder | 16.87 | 12.84 | 11 | 145577 | 357 | 56146122 |
Tumour invasion | 16.86 | 12.84 | 8 | 145580 | 137 | 56146342 |
Uterine atrophy | 16.81 | 12.84 | 6 | 145582 | 47 | 56146432 |
Pancreatic failure | 16.80 | 12.84 | 16 | 145572 | 909 | 56145570 |
Exposed bone in jaw | 16.76 | 12.84 | 28 | 145560 | 2820 | 56143659 |
Oesophageal varices haemorrhage | 16.75 | 12.84 | 17 | 145571 | 1044 | 56145435 |
Carbohydrate antigen 19-9 increased | 16.69 | 12.84 | 9 | 145579 | 204 | 56146275 |
Ovarian failure | 16.68 | 12.84 | 18 | 145570 | 1187 | 56145292 |
Subdural haematoma | 16.67 | 12.84 | 7 | 145581 | 13492 | 56132987 |
Gingival bleeding | 16.63 | 12.84 | 67 | 145521 | 11599 | 56134880 |
Nail avulsion | 16.60 | 12.84 | 8 | 145580 | 142 | 56146337 |
Myeloproliferative neoplasm | 16.56 | 12.84 | 12 | 145576 | 464 | 56146015 |
Endometrial adenocarcinoma | 16.52 | 12.84 | 18 | 145570 | 1200 | 56145279 |
Toxic neuropathy | 16.50 | 12.84 | 11 | 145577 | 371 | 56146108 |
Laryngeal oedema | 16.50 | 12.84 | 40 | 145548 | 5270 | 56141209 |
Tongue disorder | 16.49 | 12.84 | 3 | 145585 | 10033 | 56136446 |
Median nerve injury | 16.43 | 12.84 | 5 | 145583 | 22 | 56146457 |
Mood altered | 16.37 | 12.84 | 7 | 145581 | 13348 | 56133131 |
Restless legs syndrome | 16.29 | 12.84 | 12 | 145576 | 16935 | 56129544 |
Weight decreased | 16.28 | 12.84 | 486 | 145102 | 240228 | 55906251 |
Tumour fistulisation | 16.25 | 12.84 | 5 | 145583 | 23 | 56146456 |
Distal intestinal obstruction syndrome | 16.24 | 12.84 | 11 | 145577 | 381 | 56146098 |
Bronchopleural fistula | 16.23 | 12.84 | 9 | 145579 | 216 | 56146263 |
Angioedema | 16.19 | 12.84 | 54 | 145534 | 41399 | 56105080 |
Product storage error | 16.08 | 12.84 | 7 | 145581 | 13206 | 56133273 |
Lupus-like syndrome | 16.07 | 12.84 | 6 | 145582 | 12421 | 56134058 |
Thyroiditis | 16.04 | 12.84 | 23 | 145565 | 2029 | 56144450 |
Labelled drug-drug interaction medication error | 16.01 | 12.84 | 5 | 145583 | 11581 | 56134898 |
Thyroid disorder | 16.01 | 12.84 | 8 | 145580 | 13930 | 56132549 |
Immediate post-injection reaction | 15.99 | 12.84 | 11 | 145577 | 391 | 56146088 |
Localised infection | 15.98 | 12.84 | 29 | 145559 | 27383 | 56119096 |
Immune-mediated pancreatitis | 15.95 | 12.84 | 7 | 145581 | 99 | 56146380 |
Keratitis | 15.92 | 12.84 | 28 | 145560 | 2939 | 56143540 |
Aspartate aminotransferase increased | 15.86 | 12.84 | 301 | 145287 | 82301 | 56064178 |
Vaginal cuff dehiscence | 15.81 | 12.84 | 4 | 145584 | 7 | 56146472 |
Ileal perforation | 15.77 | 12.84 | 11 | 145577 | 400 | 56146079 |
Pulmonary artery stenosis | 15.74 | 12.84 | 8 | 145580 | 160 | 56146319 |
Urosepsis | 15.70 | 12.84 | 85 | 145503 | 16631 | 56129848 |
Cholecystectomy | 15.68 | 12.84 | 3 | 145585 | 9681 | 56136798 |
Gene mutation | 15.59 | 12.84 | 19 | 145569 | 1430 | 56145049 |
Artificial menopause | 15.59 | 12.84 | 5 | 145583 | 27 | 56146452 |
Cardiac pseudoaneurysm | 15.59 | 12.84 | 5 | 145583 | 27 | 56146452 |
Lividity | 15.55 | 12.84 | 9 | 145579 | 235 | 56146244 |
Application site recall reaction | 15.47 | 12.84 | 4 | 145584 | 8 | 56146471 |
Blood lactate dehydrogenase increased | 15.46 | 12.84 | 99 | 145489 | 20576 | 56125903 |
Embolism venous | 15.44 | 12.84 | 27 | 145561 | 2821 | 56143658 |
Myeloid leukaemia | 15.44 | 12.84 | 10 | 145578 | 321 | 56146158 |
Ototoxicity | 15.42 | 12.84 | 17 | 145571 | 1149 | 56145330 |
Chemotherapy | 15.32 | 12.84 | 19 | 145569 | 1456 | 56145023 |
Carcinoid tumour pulmonary | 15.30 | 12.84 | 11 | 145577 | 420 | 56146059 |
Mucosal dryness | 15.29 | 12.84 | 25 | 145563 | 2473 | 56144006 |
Biliary obstruction | 15.27 | 12.84 | 25 | 145563 | 2476 | 56144003 |
Sputum discoloured | 15.25 | 12.84 | 9 | 145579 | 14283 | 56132196 |
Speech disorder | 15.22 | 12.84 | 48 | 145540 | 37445 | 56109034 |
Hiatus hernia | 15.21 | 12.84 | 17 | 145571 | 19635 | 56126844 |
Orbital myositis | 15.15 | 12.84 | 5 | 145583 | 30 | 56146449 |
Onychomadesis | 15.14 | 12.84 | 36 | 145552 | 4685 | 56141794 |
Faeces discoloured | 15.12 | 12.84 | 13 | 145575 | 16983 | 56129496 |
Glycosylated haemoglobin increased | 15.11 | 12.84 | 5 | 145583 | 11160 | 56135319 |
BRCA2 gene mutation | 15.10 | 12.84 | 6 | 145582 | 65 | 56146414 |
Pain in jaw | 15.06 | 12.84 | 53 | 145535 | 39983 | 56106496 |
Cholelithiasis | 15.01 | 12.84 | 52 | 145536 | 39412 | 56107067 |
Product supply issue | 15.01 | 12.84 | 19 | 145569 | 1487 | 56144992 |
Gamma-glutamyltransferase increased | 15.00 | 12.84 | 134 | 145454 | 30871 | 56115608 |
Ovarian cyst | 14.98 | 12.84 | 10 | 145578 | 14856 | 56131623 |
Nail pigmentation | 14.89 | 12.84 | 8 | 145580 | 180 | 56146299 |
Granulocyte count | 14.88 | 12.84 | 3 | 145585 | 0 | 56146479 |
Porocarcinoma | 14.88 | 12.84 | 3 | 145585 | 0 | 56146479 |
Ankyloglossia acquired | 14.88 | 12.84 | 3 | 145585 | 0 | 56146479 |
Myiasis | 14.88 | 12.84 | 3 | 145585 | 0 | 56146479 |
Therapeutic response decreased | 14.84 | 12.84 | 78 | 145510 | 52680 | 56093799 |
Tuberculosis | 14.82 | 12.84 | 5 | 145583 | 11024 | 56135455 |
Limb discomfort | 14.78 | 12.84 | 29 | 145559 | 26593 | 56119886 |
Hyperbilirubinaemia | 14.76 | 12.84 | 59 | 145529 | 10176 | 56136303 |
Pulmonary congestion | 14.74 | 12.84 | 12 | 145576 | 16103 | 56130376 |
Nasal disorder | 14.68 | 12.84 | 25 | 145563 | 2557 | 56143922 |
Affect lability | 14.67 | 12.84 | 4 | 145584 | 10121 | 56136358 |
Obstructive shock | 14.62 | 12.84 | 5 | 145583 | 34 | 56146445 |
Ovarian endometrioid carcinoma | 14.62 | 12.84 | 5 | 145583 | 34 | 56146445 |
Anger | 14.50 | 12.84 | 6 | 145582 | 11666 | 56134813 |
Scar | 14.49 | 12.84 | 7 | 145581 | 12426 | 56134053 |
Hypothalamo-pituitary disorder | 14.44 | 12.84 | 13 | 145575 | 687 | 56145792 |
Cardiac failure congestive | 14.42 | 12.84 | 151 | 145437 | 87569 | 56058910 |
Ureteric stenosis | 14.42 | 12.84 | 12 | 145576 | 570 | 56145909 |
Bone marrow disorder | 14.41 | 12.84 | 22 | 145566 | 2052 | 56144427 |
Bacterial diarrhoea | 14.41 | 12.84 | 6 | 145582 | 74 | 56146405 |
Lung infiltration | 14.39 | 12.84 | 72 | 145516 | 13666 | 56132813 |
Hepatic cancer metastatic | 14.38 | 12.84 | 10 | 145578 | 362 | 56146117 |
Polymicrogyria | 14.34 | 12.84 | 6 | 145582 | 75 | 56146404 |
Extrapyramidal disorder | 14.33 | 12.84 | 7 | 145581 | 12349 | 56134130 |
Toxic cardiomyopathy | 14.29 | 12.84 | 7 | 145581 | 129 | 56146350 |
Thinking abnormal | 14.27 | 12.84 | 4 | 145584 | 9937 | 56136542 |
Productive cough | 14.26 | 12.84 | 86 | 145502 | 56146 | 56090333 |
Lichenoid keratosis | 14.23 | 12.84 | 18 | 145570 | 1407 | 56145072 |
Transaminases abnormal | 14.22 | 12.84 | 12 | 145576 | 581 | 56145898 |
Anhedonia | 14.21 | 12.84 | 4 | 145584 | 9910 | 56136569 |
Clonal evolution | 14.20 | 12.84 | 6 | 145582 | 77 | 56146402 |
Status epilepticus | 14.20 | 12.84 | 11 | 145577 | 15130 | 56131349 |
Hernia | 14.17 | 12.84 | 5 | 145583 | 10718 | 56135761 |
Hypercalcaemia of malignancy | 14.10 | 12.84 | 8 | 145580 | 201 | 56146278 |
Oesophageal squamous cell carcinoma | 14.10 | 12.84 | 7 | 145581 | 133 | 56146346 |
Seizure | 14.09 | 12.84 | 233 | 145355 | 124886 | 56021593 |
Peritoneal lesion | 14.09 | 12.84 | 4 | 145584 | 13 | 56146466 |
Mechanical ileus | 14.07 | 12.84 | 10 | 145578 | 375 | 56146104 |
Panniculitis | 14.05 | 12.84 | 4 | 145584 | 9838 | 56136641 |
Pulpitis dental | 13.98 | 12.84 | 14 | 145574 | 846 | 56145633 |
Dysuria | 13.95 | 12.84 | 131 | 145457 | 30598 | 56115881 |
Failure to thrive | 13.92 | 12.84 | 43 | 145545 | 6527 | 56139952 |
Cannabinoid hyperemesis syndrome | 13.92 | 12.84 | 5 | 145583 | 40 | 56146439 |
Rotator cuff syndrome | 13.90 | 12.84 | 7 | 145581 | 12136 | 56134343 |
Meibomian gland dysfunction | 13.86 | 12.84 | 7 | 145581 | 138 | 56146341 |
Cholecystitis chronic | 13.85 | 12.84 | 4 | 145584 | 9744 | 56136735 |
Liver function test abnormal | 13.71 | 12.84 | 66 | 145522 | 45605 | 56100874 |
Cystitis haemorrhagic | 13.70 | 12.84 | 31 | 145557 | 3906 | 56142573 |
Nail infection | 13.67 | 12.84 | 23 | 145565 | 2330 | 56144149 |
Delusion | 13.55 | 12.84 | 6 | 145582 | 11209 | 56135270 |
Carbohydrate antigen 15-3 | 13.48 | 12.84 | 6 | 145582 | 88 | 56146391 |
Hypergeusia | 13.44 | 12.84 | 4 | 145584 | 16 | 56146463 |
Uterine adhesions | 13.40 | 12.84 | 5 | 145583 | 45 | 56146434 |
Movement disorder | 13.39 | 12.84 | 18 | 145570 | 19180 | 56127299 |
Cardiac disorder | 13.38 | 12.84 | 67 | 145521 | 45820 | 56100659 |
Morphoea | 13.36 | 12.84 | 9 | 145579 | 309 | 56146170 |
Extremity necrosis | 13.34 | 12.84 | 18 | 145570 | 1500 | 56144979 |
Hyperphosphataemia | 13.32 | 12.84 | 21 | 145567 | 2014 | 56144465 |
Aortic dissection | 13.32 | 12.84 | 20 | 145568 | 1839 | 56144640 |
Pharyngitis streptococcal | 13.31 | 12.84 | 4 | 145584 | 9494 | 56136985 |
Metastatic gastric cancer | 13.30 | 12.84 | 7 | 145581 | 151 | 56146328 |
Hyperferritinaemia | 13.25 | 12.84 | 7 | 145581 | 152 | 56146327 |
Metastases to vagina | 13.25 | 12.84 | 4 | 145584 | 17 | 56146462 |
Carcinoembryonic antigen | 13.24 | 12.84 | 6 | 145582 | 92 | 56146387 |
Dandy-Walker syndrome | 13.24 | 12.84 | 6 | 145582 | 92 | 56146387 |
Anal sphincter atony | 13.23 | 12.84 | 8 | 145580 | 227 | 56146252 |
Systolic dysfunction | 13.23 | 12.84 | 18 | 145570 | 1512 | 56144967 |
Deformity | 13.18 | 12.84 | 5 | 145583 | 10250 | 56136229 |
Upper-airway cough syndrome | 13.18 | 12.84 | 4 | 145584 | 9434 | 56137045 |
Blood pressure diastolic increased | 13.15 | 12.84 | 3 | 145585 | 8558 | 56137921 |
Opsoclonus myoclonus | 13.13 | 12.84 | 7 | 145581 | 155 | 56146324 |
Cognitive disorder | 13.07 | 12.84 | 74 | 145514 | 49059 | 56097420 |
Foetal malnutrition | 13.07 | 12.84 | 6 | 145582 | 95 | 56146384 |
Torsade de pointes | 13.04 | 12.84 | 8 | 145580 | 12432 | 56134047 |
Respiratory depression | 13.03 | 12.84 | 8 | 145580 | 12427 | 56134052 |
Impaired quality of life | 12.95 | 12.84 | 3 | 145585 | 8471 | 56138008 |
Ulcer | 12.92 | 12.84 | 24 | 145564 | 22461 | 56124018 |
Empyema | 12.90 | 12.84 | 20 | 145568 | 1891 | 56144588 |
Peritoneal fluid analysis abnormal | 12.89 | 12.84 | 4 | 145584 | 19 | 56146460 |
Transformation to acute myeloid leukaemia | 12.89 | 12.84 | 8 | 145580 | 238 | 56146241 |
Walking aid user | 12.88 | 12.84 | 3 | 145585 | 8440 | 56138039 |
Dermatitis | 12.87 | 12.84 | 75 | 145513 | 15082 | 56131397 |
Lymphorrhoea | 12.85 | 12.84 | 5 | 145583 | 51 | 56146428 |
Hereditary motor and sensory neuropathy | 12.84 | 12.84 | 6 | 145582 | 99 | 56146380 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 693.15 | 15.65 | 723 | 47912 | 78275 | 31570434 |
Febrile neutropenia | 599.89 | 15.65 | 831 | 47804 | 121018 | 31527691 |
Neutropenia | 585.74 | 15.65 | 885 | 47750 | 139479 | 31509230 |
Interstitial lung disease | 394.03 | 15.65 | 478 | 48157 | 60925 | 31587784 |
Pancreatic carcinoma metastatic | 369.66 | 15.65 | 147 | 48488 | 2797 | 31645912 |
Neuropathy peripheral | 359.60 | 15.65 | 508 | 48127 | 75141 | 31573568 |
Pancreatic carcinoma | 314.35 | 15.65 | 184 | 48451 | 8416 | 31640293 |
Disease progression | 308.43 | 15.65 | 521 | 48114 | 89943 | 31558766 |
Neutrophil count decreased | 265.15 | 15.65 | 341 | 48294 | 46053 | 31602656 |
Leukopenia | 257.98 | 15.65 | 377 | 48258 | 57451 | 31591258 |
Anaemia | 255.07 | 15.65 | 812 | 47823 | 212710 | 31435999 |
Thrombocytopenia | 243.73 | 15.65 | 618 | 48017 | 142129 | 31506580 |
Pneumonitis | 240.69 | 15.65 | 265 | 48370 | 30387 | 31618322 |
Non-small cell lung cancer | 228.26 | 15.65 | 116 | 48519 | 3993 | 31644716 |
Alopecia | 200.11 | 15.65 | 200 | 48435 | 20495 | 31628214 |
Death | 177.31 | 15.65 | 1048 | 47587 | 359521 | 31289188 |
Myelosuppression | 176.13 | 15.65 | 161 | 48474 | 14759 | 31633950 |
Cholangitis | 168.46 | 15.65 | 121 | 48514 | 7865 | 31640844 |
Radiation pneumonitis | 144.55 | 15.65 | 72 | 48563 | 2372 | 31646337 |
Mucosal inflammation | 144.13 | 15.65 | 218 | 48417 | 34209 | 31614500 |
Cystoid macular oedema | 135.15 | 15.65 | 48 | 48587 | 657 | 31648052 |
Product dose omission issue | 130.19 | 15.65 | 8 | 48627 | 105578 | 31543131 |
Completed suicide | 122.37 | 15.65 | 4 | 48631 | 91510 | 31557199 |
Metastases to central nervous system | 119.82 | 15.65 | 97 | 48538 | 7539 | 31641170 |
Bone marrow failure | 118.13 | 15.65 | 178 | 48457 | 27830 | 31620879 |
Haemoptysis | 114.23 | 15.65 | 189 | 48446 | 32000 | 31616709 |
Neoplasm progression | 114.11 | 15.65 | 148 | 48487 | 20124 | 31628585 |
Haematotoxicity | 108.49 | 15.65 | 89 | 48546 | 7048 | 31641661 |
Flushing | 107.04 | 15.65 | 177 | 48458 | 29951 | 31618758 |
Polyneuropathy | 104.60 | 15.65 | 114 | 48521 | 12908 | 31635801 |
General physical health deterioration | 104.10 | 15.65 | 396 | 48239 | 113039 | 31535670 |
Peripheral sensory neuropathy | 102.87 | 15.65 | 82 | 48553 | 6233 | 31642476 |
Overdose | 97.03 | 15.65 | 9 | 48626 | 84655 | 31564054 |
Immune-mediated hepatitis | 96.01 | 15.65 | 49 | 48586 | 1701 | 31647008 |
Neurotoxicity | 93.72 | 15.65 | 120 | 48515 | 16106 | 31632603 |
Pyrexia | 89.20 | 15.65 | 781 | 47854 | 303059 | 31345650 |
Radiation oesophagitis | 88.59 | 15.65 | 31 | 48604 | 405 | 31648304 |
Pneumothorax | 88.29 | 15.65 | 119 | 48516 | 16791 | 31631918 |
Depression | 84.66 | 15.65 | 18 | 48617 | 90797 | 31557912 |
Fall | 84.17 | 15.65 | 97 | 48538 | 185992 | 31462717 |
White blood cell count decreased | 82.52 | 15.65 | 308 | 48327 | 87090 | 31561619 |
Therapy partial responder | 81.73 | 15.65 | 73 | 48562 | 6489 | 31642220 |
Immune-mediated lung disease | 81.26 | 15.65 | 38 | 48597 | 1086 | 31647623 |
Dehydration | 80.59 | 15.65 | 379 | 48256 | 118732 | 31529977 |
Biliary tract infection | 78.70 | 15.65 | 31 | 48604 | 574 | 31648135 |
Decreased appetite | 78.40 | 15.65 | 451 | 48184 | 152766 | 31495943 |
Plasma cell myeloma | 73.72 | 15.65 | 3 | 48632 | 56528 | 31592181 |
Thrombotic microangiopathy | 71.87 | 15.65 | 80 | 48555 | 9271 | 31639438 |
Drug ineffective | 71.84 | 15.65 | 338 | 48297 | 395235 | 31253474 |
Drug interaction | 71.46 | 15.65 | 132 | 48503 | 208411 | 31440298 |
Erythema | 70.66 | 15.65 | 277 | 48358 | 80128 | 31568581 |
Anaphylactic shock | 69.99 | 15.65 | 97 | 48538 | 14048 | 31634661 |
Pancytopenia | 69.73 | 15.65 | 292 | 48343 | 87024 | 31561685 |
Sepsis | 68.65 | 15.65 | 433 | 48202 | 151496 | 31497213 |
Headache | 67.68 | 15.65 | 111 | 48524 | 183541 | 31465168 |
Metastases to liver | 67.10 | 15.65 | 90 | 48545 | 12637 | 31636072 |
Anxiety | 66.81 | 15.65 | 28 | 48607 | 91005 | 31557704 |
Metastases to lung | 66.36 | 15.65 | 73 | 48562 | 8349 | 31640360 |
Liver abscess | 64.10 | 15.65 | 49 | 48586 | 3502 | 31645207 |
Infusion related reaction | 63.72 | 15.65 | 190 | 48445 | 47865 | 31600844 |
Gastrointestinal perforation | 63.12 | 15.65 | 49 | 48586 | 3583 | 31645126 |
Dyspnoea | 62.54 | 15.65 | 802 | 47833 | 342677 | 31306032 |
Platelet count decreased | 61.02 | 15.65 | 332 | 48303 | 110103 | 31538606 |
Tumour haemorrhage | 60.47 | 15.65 | 42 | 48593 | 2586 | 31646123 |
Nasopharyngitis | 60.03 | 15.65 | 12 | 48623 | 63233 | 31585476 |
Pneumonia | 58.96 | 15.65 | 778 | 47857 | 334534 | 31314175 |
Pulmonary toxicity | 57.61 | 15.65 | 55 | 48580 | 5322 | 31643387 |
Colitis | 56.83 | 15.65 | 146 | 48489 | 33741 | 31614968 |
Toxicity to various agents | 56.04 | 15.65 | 122 | 48513 | 181365 | 31467344 |
Joint swelling | 55.42 | 15.65 | 8 | 48627 | 53423 | 31595286 |
Adrenal insufficiency | 54.13 | 15.65 | 81 | 48554 | 12578 | 31636131 |
Insomnia | 53.97 | 15.65 | 40 | 48595 | 94796 | 31553913 |
Immune-mediated enterocolitis | 52.93 | 15.65 | 36 | 48599 | 2142 | 31646567 |
Hypersensitivity | 52.19 | 15.65 | 196 | 48439 | 55547 | 31593162 |
Kounis syndrome | 51.96 | 15.65 | 35 | 48600 | 2049 | 31646660 |
Onycholysis | 51.04 | 15.65 | 23 | 48612 | 602 | 31648107 |
Nausea | 48.97 | 15.65 | 702 | 47933 | 307245 | 31341464 |
Weight increased | 48.48 | 15.65 | 34 | 48601 | 82913 | 31565796 |
Rheumatoid arthritis | 47.67 | 15.65 | 8 | 48627 | 47801 | 31600908 |
Coronary artery disease | 47.57 | 15.65 | 7 | 48628 | 46080 | 31602629 |
Cardiac failure congestive | 47.12 | 15.65 | 32 | 48603 | 79355 | 31569354 |
Diarrhoea | 45.99 | 15.65 | 777 | 47858 | 351632 | 31297077 |
Somnolence | 45.80 | 15.65 | 51 | 48584 | 99394 | 31549315 |
Vomiting | 45.40 | 15.65 | 534 | 48101 | 223439 | 31425270 |
Metastases to meninges | 45.37 | 15.65 | 27 | 48608 | 1272 | 31647437 |
Suicidal ideation | 44.12 | 15.65 | 3 | 48632 | 36403 | 31612306 |
Psoriasis | 44.05 | 15.65 | 9 | 48626 | 46710 | 31601999 |
Tremor | 43.78 | 15.65 | 32 | 48603 | 76388 | 31572321 |
Pneumatosis intestinalis | 43.69 | 15.65 | 40 | 48595 | 3671 | 31645038 |
Electrocardiogram QT prolonged | 43.60 | 15.65 | 4 | 48631 | 37983 | 31610726 |
Intentional product misuse | 43.55 | 15.65 | 4 | 48631 | 37947 | 31610762 |
Stomatitis | 43.18 | 15.65 | 146 | 48489 | 39292 | 31609417 |
Aggression | 42.61 | 15.65 | 4 | 48631 | 37287 | 31611422 |
Injection site pain | 41.54 | 15.65 | 3 | 48632 | 34631 | 31614078 |
Bronchial fistula | 41.32 | 15.65 | 14 | 48621 | 165 | 31648544 |
Bradycardia | 41.06 | 15.65 | 28 | 48607 | 69299 | 31579410 |
Tracheal fistula | 40.83 | 15.65 | 12 | 48623 | 85 | 31648624 |
Pulmonary radiation injury | 40.67 | 15.65 | 11 | 48624 | 55 | 31648654 |
Pancreatic enzyme abnormality | 40.67 | 15.65 | 11 | 48624 | 55 | 31648654 |
Hospitalisation | 40.44 | 15.65 | 13 | 48622 | 49794 | 31598915 |
Cardiac disorder | 40.37 | 15.65 | 6 | 48629 | 39208 | 31609501 |
Pleural effusion | 39.84 | 15.65 | 223 | 48412 | 74697 | 31574012 |
Neutropenic sepsis | 39.03 | 15.65 | 69 | 48566 | 12310 | 31636399 |
Metastases to bone | 38.86 | 15.65 | 64 | 48571 | 10784 | 31637925 |
Scleroderma-like reaction | 38.78 | 15.65 | 10 | 48625 | 40 | 31648669 |
Arthralgia | 38.76 | 15.65 | 112 | 48523 | 151312 | 31497397 |
Hypoglycaemia | 38.45 | 15.65 | 15 | 48620 | 50931 | 31597778 |
Performance status decreased | 38.42 | 15.65 | 38 | 48597 | 3840 | 31644869 |
Tracheo-oesophageal fistula | 38.41 | 15.65 | 17 | 48618 | 426 | 31648283 |
Prostate cancer | 38.14 | 15.65 | 6 | 48629 | 37595 | 31611114 |
Embolism | 37.78 | 15.65 | 51 | 48584 | 7202 | 31641507 |
Musculoskeletal stiffness | 36.87 | 15.65 | 9 | 48626 | 41316 | 31607393 |
Immune-mediated hepatic disorder | 36.70 | 15.65 | 18 | 48617 | 573 | 31648136 |
Oesophagitis | 36.33 | 15.65 | 67 | 48568 | 12349 | 31636360 |
Immune-mediated dermatitis | 36.27 | 15.65 | 13 | 48622 | 183 | 31648526 |
Skin toxicity | 36.19 | 15.65 | 38 | 48597 | 4121 | 31644588 |
Hallucination | 36.14 | 15.65 | 13 | 48622 | 46397 | 31602312 |
Enterocolitis infectious | 35.46 | 15.65 | 24 | 48611 | 1416 | 31647293 |
Right ventricular ejection fraction decreased | 34.90 | 15.65 | 9 | 48626 | 36 | 31648673 |
Agitation | 34.67 | 15.65 | 20 | 48615 | 54149 | 31594560 |
Enterocolitis | 34.67 | 15.65 | 49 | 48586 | 7225 | 31641484 |
Septic shock | 34.56 | 15.65 | 196 | 48439 | 65962 | 31582747 |
Therapeutic product effect decreased | 34.56 | 15.65 | 4 | 48631 | 31618 | 31617091 |
Recall phenomenon | 34.49 | 15.65 | 17 | 48618 | 547 | 31648162 |
Hypertransaminasaemia | 33.37 | 15.65 | 37 | 48598 | 4267 | 31644442 |
Pulmonary embolism | 33.32 | 15.65 | 227 | 48408 | 81419 | 31567290 |
Blood glucose increased | 33.17 | 15.65 | 27 | 48608 | 61056 | 31587653 |
Asthma | 33.07 | 15.65 | 12 | 48623 | 42599 | 31606110 |
Gastritis bacterial | 31.96 | 15.65 | 12 | 48623 | 194 | 31648515 |
Teratoma benign | 31.86 | 15.65 | 8 | 48627 | 28 | 31648681 |
Gastrointestinal toxicity | 31.74 | 15.65 | 27 | 48608 | 2247 | 31646462 |
Dysphagia | 31.54 | 15.65 | 173 | 48462 | 57503 | 31591206 |
Tidal volume decreased | 31.02 | 15.65 | 8 | 48627 | 32 | 31648677 |
Memory impairment | 30.86 | 15.65 | 10 | 48625 | 38120 | 31610589 |
Oxygen saturation decreased | 30.77 | 15.65 | 153 | 48482 | 48962 | 31599747 |
Intestinal perforation | 30.74 | 15.65 | 50 | 48585 | 8339 | 31640370 |
Brain teratoma | 30.70 | 15.65 | 7 | 48628 | 14 | 31648695 |
Bronchospasm | 30.69 | 15.65 | 55 | 48580 | 9917 | 31638792 |
Angioedema | 30.62 | 15.65 | 7 | 48628 | 33611 | 31615098 |
Adrenocorticotropic hormone deficiency | 30.40 | 15.65 | 17 | 48618 | 711 | 31647998 |
Blood pressure increased | 30.34 | 15.65 | 47 | 48588 | 79586 | 31569123 |
Confusional state | 30.32 | 15.65 | 104 | 48531 | 133230 | 31515479 |
Condition aggravated | 30.28 | 15.65 | 139 | 48496 | 163870 | 31484839 |
Metastases to peritoneum | 30.16 | 15.65 | 23 | 48612 | 1637 | 31647072 |
Haemolytic uraemic syndrome | 29.72 | 15.65 | 25 | 48610 | 2049 | 31646660 |
Coma | 29.62 | 15.65 | 13 | 48622 | 41137 | 31607572 |
Ductal adenocarcinoma of pancreas | 29.41 | 15.65 | 8 | 48627 | 41 | 31648668 |
Metastatic gastric cancer | 29.34 | 15.65 | 11 | 48624 | 177 | 31648532 |
Nail dystrophy | 29.17 | 15.65 | 11 | 48624 | 180 | 31648529 |
Disseminated intravascular coagulation | 28.92 | 15.65 | 83 | 48552 | 20454 | 31628255 |
Dizziness | 28.90 | 15.65 | 183 | 48452 | 198964 | 31449745 |
Unmasking of previously unidentified disease | 28.64 | 15.65 | 17 | 48618 | 797 | 31647912 |
Pulmonary hypoplasia | 28.59 | 15.65 | 14 | 48621 | 444 | 31648265 |
Anaphylactic reaction | 28.55 | 15.65 | 105 | 48530 | 29448 | 31619261 |
International normalised ratio increased | 28.51 | 15.65 | 17 | 48618 | 45206 | 31603503 |
Wrong technique in product usage process | 28.34 | 15.65 | 8 | 48627 | 33335 | 31615374 |
Feeling abnormal | 27.61 | 15.65 | 28 | 48607 | 56974 | 31591735 |
Myocardial infarction | 27.52 | 15.65 | 86 | 48549 | 113368 | 31535341 |
Fluid retention | 27.45 | 15.65 | 3 | 48632 | 24799 | 31623910 |
Periarticular thenar erythema with onycholysis | 27.41 | 15.65 | 5 | 48630 | 0 | 31648709 |
Tumour necrosis | 27.38 | 15.65 | 19 | 48616 | 1168 | 31647541 |
Lung adenocarcinoma | 27.34 | 15.65 | 34 | 48601 | 4428 | 31644281 |
Oesophagopleural fistula | 27.30 | 15.65 | 8 | 48627 | 56 | 31648653 |
Off label use | 26.97 | 15.65 | 710 | 47925 | 346564 | 31302145 |
Muscle spasms | 26.33 | 15.65 | 40 | 48595 | 68278 | 31580431 |
Hypoxia | 26.23 | 15.65 | 149 | 48486 | 50164 | 31598545 |
Macular oedema | 26.16 | 15.65 | 26 | 48609 | 2642 | 31646067 |
Influenza | 26.11 | 15.65 | 18 | 48617 | 44307 | 31604402 |
Abnormal behaviour | 26.07 | 15.65 | 3 | 48632 | 23825 | 31624884 |
Discontinued product administered | 25.99 | 15.65 | 6 | 48629 | 13 | 31648696 |
Neutropenic colitis | 25.97 | 15.65 | 26 | 48609 | 2666 | 31646043 |
Peripheral swelling | 25.90 | 15.65 | 40 | 48595 | 67825 | 31580884 |
Heart rate decreased | 25.52 | 15.65 | 6 | 48629 | 28260 | 31620449 |
Acute respiratory distress syndrome | 25.24 | 15.65 | 89 | 48546 | 24451 | 31624258 |
Cytomegalovirus infection | 24.93 | 15.65 | 4 | 48631 | 24703 | 31624006 |
Urticaria | 24.85 | 15.65 | 31 | 48604 | 57486 | 31591223 |
Eastern Cooperative Oncology Group performance status worsened | 24.81 | 15.65 | 16 | 48619 | 870 | 31647839 |
Dermatitis acneiform | 24.79 | 15.65 | 37 | 48598 | 5730 | 31642979 |
Irritability | 24.75 | 15.65 | 3 | 48632 | 22886 | 31625823 |
Inappropriate schedule of product administration | 24.57 | 15.65 | 25 | 48610 | 50798 | 31597911 |
Lung abscess | 24.25 | 15.65 | 24 | 48611 | 2427 | 31646282 |
Erythema multiforme | 24.18 | 15.65 | 44 | 48591 | 8027 | 31640682 |
Pneumoperitoneum | 23.95 | 15.65 | 20 | 48615 | 1623 | 31647086 |
Taeniasis | 23.53 | 15.65 | 7 | 48628 | 52 | 31648657 |
Infectious pleural effusion | 23.52 | 15.65 | 22 | 48613 | 2075 | 31646634 |
Oligohydramnios | 23.12 | 15.65 | 11 | 48624 | 327 | 31648382 |
Pancreatic carcinoma recurrent | 23.07 | 15.65 | 7 | 48628 | 56 | 31648653 |
Ileus | 23.02 | 15.65 | 63 | 48572 | 15106 | 31633603 |
Chronic kidney disease | 22.93 | 15.65 | 15 | 48620 | 37960 | 31610749 |
Lymphangiosis carcinomatosa | 22.88 | 15.65 | 15 | 48620 | 839 | 31647870 |
Lung squamous cell carcinoma metastatic | 22.86 | 15.65 | 7 | 48628 | 58 | 31648651 |
Stress cardiomyopathy | 22.46 | 15.65 | 20 | 48615 | 1770 | 31646939 |
Feeling hot | 22.27 | 15.65 | 65 | 48570 | 16168 | 31632541 |
Metastases to lymph nodes | 22.21 | 15.65 | 30 | 48605 | 4238 | 31644471 |
Aortic injury | 21.93 | 15.65 | 5 | 48630 | 10 | 31648699 |
Loss of personal independence in daily activities | 21.89 | 15.65 | 8 | 48627 | 28280 | 31620429 |
Disturbance in attention | 21.84 | 15.65 | 4 | 48631 | 22446 | 31626263 |
Sinusitis | 21.48 | 15.65 | 15 | 48620 | 36681 | 31612028 |
Sense of oppression | 21.33 | 15.65 | 12 | 48623 | 508 | 31648201 |
Non-small cell lung cancer stage IV | 20.89 | 15.65 | 9 | 48626 | 211 | 31648498 |
Metabolic acidosis | 20.86 | 15.65 | 18 | 48617 | 39559 | 31609150 |
Second primary malignancy | 20.64 | 15.65 | 38 | 48597 | 6994 | 31641715 |
Radiation skin injury | 20.56 | 15.65 | 13 | 48622 | 683 | 31648026 |
Metastases to skin | 20.52 | 15.65 | 11 | 48624 | 423 | 31648286 |
Tumour pseudoprogression | 20.52 | 15.65 | 11 | 48624 | 423 | 31648286 |
Lactic acidosis | 20.13 | 15.65 | 12 | 48623 | 31925 | 31616784 |
Proteinuria | 20.08 | 15.65 | 64 | 48571 | 16699 | 31632010 |
Seizure | 19.94 | 15.65 | 82 | 48553 | 99686 | 31549023 |
Blood creatine phosphokinase increased | 19.89 | 15.65 | 21 | 48614 | 41953 | 31606756 |
Pain | 19.84 | 15.65 | 187 | 48448 | 186572 | 31462137 |
Cataract | 19.70 | 15.65 | 6 | 48629 | 23801 | 31624908 |
Pulmonary artery occlusion | 19.69 | 15.65 | 4 | 48631 | 3 | 31648706 |
Oesophagobronchial fistula | 19.56 | 15.65 | 8 | 48627 | 164 | 31648545 |
Gastric perforation | 19.54 | 15.65 | 21 | 48614 | 2338 | 31646371 |
Cachexia | 19.49 | 15.65 | 36 | 48599 | 6643 | 31642066 |
Rhabdomyolysis | 19.36 | 15.65 | 43 | 48592 | 63538 | 31585171 |
Subdural haematoma | 19.30 | 15.65 | 3 | 48632 | 18968 | 31629741 |
Hyperkalaemia | 19.20 | 15.65 | 44 | 48591 | 64307 | 31584402 |
Abdominal discomfort | 19.10 | 15.65 | 31 | 48604 | 51536 | 31597173 |
Lung disorder | 19.07 | 15.65 | 99 | 48536 | 32213 | 31616496 |
Adenocarcinoma pancreas | 19.06 | 15.65 | 16 | 48619 | 1308 | 31647401 |
Nasal congestion | 19.05 | 15.65 | 4 | 48631 | 20377 | 31628332 |
Eosinophilia | 18.99 | 15.65 | 6 | 48629 | 23247 | 31625462 |
Paronychia | 18.89 | 15.65 | 24 | 48611 | 3194 | 31645515 |
Herpes zoster | 18.83 | 15.65 | 13 | 48622 | 31980 | 31616729 |
Hypopituitarism | 18.70 | 15.65 | 19 | 48616 | 1982 | 31646727 |
Lymphopenia | 18.36 | 15.65 | 56 | 48579 | 14273 | 31634436 |
Miller Fisher syndrome | 18.33 | 15.65 | 6 | 48629 | 63 | 31648646 |
Transient ischaemic attack | 18.28 | 15.65 | 7 | 48628 | 24049 | 31624660 |
Abdominal pain | 18.26 | 15.65 | 320 | 48315 | 145632 | 31503077 |
Hepatic function abnormal | 18.25 | 15.65 | 117 | 48518 | 41105 | 31607604 |
Pulmonary cavitation | 18.13 | 15.65 | 13 | 48622 | 842 | 31647867 |
Metastases to kidney | 18.08 | 15.65 | 9 | 48626 | 296 | 31648413 |
Pneumonia bacterial | 17.91 | 15.65 | 45 | 48590 | 10251 | 31638458 |
Pericardial effusion | 17.87 | 15.65 | 75 | 48560 | 22348 | 31626361 |
Pain in extremity | 17.76 | 15.65 | 105 | 48530 | 116098 | 31532611 |
Arthritis | 17.67 | 15.65 | 10 | 48625 | 27375 | 31621334 |
Hiccups | 17.66 | 15.65 | 42 | 48593 | 9245 | 31639464 |
Immune-mediated pancreatitis | 17.61 | 15.65 | 6 | 48629 | 72 | 31648637 |
Product use issue | 17.60 | 15.65 | 38 | 48597 | 56721 | 31591988 |
Tumour marker increased | 17.59 | 15.65 | 11 | 48624 | 567 | 31648142 |
Contusion | 17.43 | 15.65 | 15 | 48620 | 33013 | 31615696 |
Balance disorder | 17.42 | 15.65 | 19 | 48616 | 37403 | 31611306 |
Upper respiratory tract infection | 17.26 | 15.65 | 12 | 48623 | 29410 | 31619299 |
Vascular pseudoaneurysm ruptured | 17.17 | 15.65 | 6 | 48629 | 78 | 31648631 |
Treatment noncompliance | 17.13 | 15.65 | 9 | 48626 | 25675 | 31623034 |
Hypophagia | 17.00 | 15.65 | 73 | 48562 | 21969 | 31626740 |
Rhinorrhoea | 16.99 | 15.65 | 7 | 48628 | 23005 | 31625704 |
Blood thyroid stimulating hormone abnormal | 16.88 | 15.65 | 9 | 48626 | 342 | 31648367 |
Supraventricular tachycardia | 16.85 | 15.65 | 44 | 48591 | 10263 | 31638446 |
Multiple-drug resistance | 16.82 | 15.65 | 27 | 48608 | 4453 | 31644256 |
Metastases to the mediastinum | 16.81 | 15.65 | 8 | 48627 | 238 | 31648471 |
Portal venous gas | 16.79 | 15.65 | 9 | 48626 | 346 | 31648363 |
Immune-mediated nephritis | 16.75 | 15.65 | 8 | 48627 | 240 | 31648469 |
Sleep apnoea syndrome | 16.72 | 15.65 | 4 | 48631 | 18621 | 31630088 |
Hypothyroidism | 16.69 | 15.65 | 63 | 48572 | 17884 | 31630825 |
Coronary artery aneurysm | 16.64 | 15.65 | 6 | 48629 | 86 | 31648623 |
Upper gastrointestinal perforation | 16.44 | 15.65 | 3 | 48632 | 0 | 31648709 |
Anaphylactoid shock | 16.44 | 15.65 | 9 | 48626 | 361 | 31648348 |
Dysarthria | 16.34 | 15.65 | 15 | 48620 | 32002 | 31616707 |
Respiratory failure | 16.30 | 15.65 | 232 | 48403 | 101217 | 31547492 |
Hypophysitis | 16.18 | 15.65 | 18 | 48617 | 2084 | 31646625 |
Thrombocytosis | 16.17 | 15.65 | 24 | 48611 | 3699 | 31645010 |
Haemorrhage | 16.12 | 15.65 | 30 | 48605 | 47304 | 31601405 |
Tumour lysis syndrome | 15.99 | 15.65 | 56 | 48579 | 15329 | 31633380 |
Gastrooesophageal reflux disease | 15.99 | 15.65 | 17 | 48618 | 33854 | 31614855 |
Palmar-plantar erythrodysaesthesia syndrome | 15.79 | 15.65 | 56 | 48579 | 15427 | 31633282 |
Incorrect dose administered | 15.72 | 15.65 | 19 | 48616 | 35733 | 31612976 |
Dry mouth | 15.69 | 15.65 | 9 | 48626 | 24449 | 31624260 |
Colitis ischaemic | 15.66 | 15.65 | 31 | 48604 | 6021 | 31642688 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 1829.65 | 12.14 | 1837 | 162556 | 125059 | 70638992 |
Malignant neoplasm progression | 1701.23 | 12.14 | 1733 | 162660 | 120006 | 70644045 |
Neutropenia | 1669.93 | 12.14 | 2485 | 161908 | 254671 | 70509380 |
Febrile neutropenia | 1153.04 | 12.14 | 1852 | 162541 | 202466 | 70561585 |
Erythema | 1032.89 | 12.14 | 1740 | 162653 | 197823 | 70566228 |
Flushing | 1004.46 | 12.14 | 1090 | 163303 | 81082 | 70682969 |
Disease progression | 924.37 | 12.14 | 1450 | 162943 | 155222 | 70608829 |
Anaemia | 842.37 | 12.14 | 2440 | 161953 | 400983 | 70363068 |
Metastases to liver | 833.42 | 12.14 | 596 | 163797 | 25282 | 70738769 |
Neutrophil count decreased | 770.64 | 12.14 | 959 | 163434 | 82597 | 70681454 |
Metastases to bone | 766.10 | 12.14 | 535 | 163858 | 21841 | 70742210 |
Myelosuppression | 733.06 | 12.14 | 587 | 163806 | 29558 | 70734493 |
Dyspnoea | 631.27 | 12.14 | 3471 | 160922 | 766589 | 69997462 |
Breast cancer metastatic | 597.41 | 12.14 | 342 | 164051 | 9804 | 70754247 |
Rheumatoid arthritis | 583.72 | 12.14 | 21 | 164372 | 291784 | 70472267 |
Metastases to lung | 578.00 | 12.14 | 400 | 163993 | 16084 | 70747967 |
Leukopenia | 531.65 | 12.14 | 915 | 163478 | 105645 | 70658406 |
Polyneuropathy | 531.27 | 12.14 | 422 | 163971 | 20993 | 70743058 |
Interstitial lung disease | 528.98 | 12.14 | 904 | 163489 | 103781 | 70660270 |
Thrombocytopenia | 528.62 | 12.14 | 1478 | 162915 | 237632 | 70526419 |
Neoplasm progression | 502.38 | 12.14 | 571 | 163822 | 44657 | 70719394 |
Completed suicide | 498.98 | 12.14 | 5 | 164388 | 227130 | 70536921 |
Pneumonitis | 492.56 | 12.14 | 620 | 163773 | 53977 | 70710074 |
Peripheral sensory neuropathy | 479.82 | 12.14 | 317 | 164076 | 11793 | 70752258 |
Palmar-plantar erythrodysaesthesia syndrome | 470.30 | 12.14 | 457 | 163936 | 29790 | 70734261 |
Pancreatic carcinoma metastatic | 447.09 | 12.14 | 205 | 164188 | 3635 | 70760416 |
Drug ineffective | 432.86 | 12.14 | 964 | 163429 | 938788 | 69825263 |
Joint swelling | 417.09 | 12.14 | 49 | 164344 | 253162 | 70510889 |
Metastases to central nervous system | 415.82 | 12.14 | 316 | 164077 | 14718 | 70749333 |
Cystoid macular oedema | 411.55 | 12.14 | 159 | 164234 | 1793 | 70762258 |
Mucosal inflammation | 402.27 | 12.14 | 630 | 163763 | 67220 | 70696831 |
Fall | 376.16 | 12.14 | 288 | 164105 | 443808 | 70320243 |
Haematotoxicity | 366.29 | 12.14 | 282 | 164111 | 13392 | 70750659 |
Neurotoxicity | 362.90 | 12.14 | 395 | 163998 | 29431 | 70734620 |
Product dose omission issue | 360.81 | 12.14 | 41 | 164352 | 217427 | 70546624 |
Anaphylactic shock | 340.26 | 12.14 | 398 | 163995 | 32092 | 70731959 |
Acute myeloid leukaemia | 339.10 | 12.14 | 388 | 164005 | 30552 | 70733499 |
Bone marrow failure | 338.84 | 12.14 | 489 | 163904 | 48521 | 70715530 |
Metastases to lymph nodes | 332.86 | 12.14 | 228 | 164165 | 9010 | 70755041 |
Chest discomfort | 332.66 | 12.14 | 826 | 163567 | 123555 | 70640496 |
Drug abuse | 319.86 | 12.14 | 4 | 164389 | 147252 | 70616799 |
Feeling hot | 316.78 | 12.14 | 472 | 163921 | 48198 | 70715853 |
Bronchospasm | 293.37 | 12.14 | 311 | 164082 | 22481 | 70741570 |
Pancreatic carcinoma | 291.93 | 12.14 | 241 | 164152 | 12663 | 70751388 |
Onycholysis | 263.82 | 12.14 | 113 | 164280 | 1690 | 70762361 |
Pseudocirrhosis | 263.23 | 12.14 | 86 | 164307 | 565 | 70763486 |
General physical health deterioration | 261.60 | 12.14 | 1162 | 163231 | 234869 | 70529182 |
Synovitis | 259.23 | 12.14 | 9 | 164384 | 129219 | 70634832 |
Therapeutic product effect decreased | 252.83 | 12.14 | 21 | 164372 | 142997 | 70621054 |
Contraindicated product administered | 251.74 | 12.14 | 15 | 164378 | 134597 | 70629454 |
Weight increased | 249.42 | 12.14 | 125 | 164268 | 242206 | 70521845 |
Nausea | 248.79 | 12.14 | 3038 | 161355 | 849050 | 69915001 |
Condition aggravated | 247.98 | 12.14 | 380 | 164013 | 427255 | 70336796 |
Headache | 247.36 | 12.14 | 619 | 163774 | 579786 | 70184265 |
Arthropathy | 242.15 | 12.14 | 31 | 164362 | 150026 | 70614025 |
Breast cancer | 239.59 | 12.14 | 340 | 164053 | 33209 | 70730842 |
Metastases to peritoneum | 236.30 | 12.14 | 133 | 164260 | 3686 | 70760365 |
Musculoskeletal stiffness | 234.91 | 12.14 | 32 | 164361 | 147728 | 70616323 |
Overdose | 234.53 | 12.14 | 53 | 164340 | 169692 | 70594359 |
Gastrointestinal perforation | 230.60 | 12.14 | 151 | 164242 | 5530 | 70758521 |
Toxicity to various agents | 224.02 | 12.14 | 337 | 164056 | 381835 | 70382216 |
Second primary malignancy | 221.46 | 12.14 | 207 | 164186 | 12844 | 70751207 |
Cholangitis | 221.08 | 12.14 | 196 | 164197 | 11353 | 70752698 |
Back pain | 220.80 | 12.14 | 1223 | 163170 | 269929 | 70494122 |
Sinusitis | 219.85 | 12.14 | 60 | 164333 | 169135 | 70594916 |
Vomiting | 216.07 | 12.14 | 2210 | 162183 | 590901 | 70173150 |
White blood cell count decreased | 214.24 | 12.14 | 871 | 163522 | 169270 | 70594781 |
Proteinuria | 210.21 | 12.14 | 298 | 164095 | 29076 | 70734975 |
Diarrhoea | 205.87 | 12.14 | 2740 | 161653 | 780601 | 69983450 |
Ejection fraction decreased | 205.42 | 12.14 | 302 | 164091 | 30460 | 70733591 |
Therapy partial responder | 204.30 | 12.14 | 194 | 164199 | 12280 | 70751771 |
Skin toxicity | 202.80 | 12.14 | 153 | 164240 | 7045 | 70757006 |
Ascites | 201.34 | 12.14 | 468 | 163925 | 67079 | 70696972 |
Platelet count decreased | 198.53 | 12.14 | 879 | 163514 | 177343 | 70586708 |
Arthralgia | 198.28 | 12.14 | 558 | 163835 | 502832 | 70261219 |
Pyrexia | 196.10 | 12.14 | 2208 | 162185 | 604744 | 70159307 |
Myelodysplastic syndrome | 189.70 | 12.14 | 286 | 164107 | 29499 | 70734552 |
Pleural effusion | 189.03 | 12.14 | 707 | 163686 | 132157 | 70631894 |
Pain | 185.62 | 12.14 | 789 | 163604 | 628027 | 70136024 |
Hypertransaminasaemia | 183.70 | 12.14 | 158 | 164235 | 8785 | 70755266 |
Glossodynia | 180.91 | 12.14 | 4 | 164389 | 86483 | 70677568 |
Depression | 174.64 | 12.14 | 124 | 164269 | 198850 | 70565201 |
Infusion related reaction | 174.27 | 12.14 | 911 | 163482 | 196623 | 70567428 |
Pemphigus | 173.07 | 12.14 | 4 | 164389 | 83032 | 70681019 |
Biliary tract infection | 172.82 | 12.14 | 75 | 164318 | 1160 | 70762891 |
Drug interaction | 172.38 | 12.14 | 394 | 163999 | 381047 | 70383004 |
Injection site pain | 172.23 | 12.14 | 32 | 164361 | 117587 | 70646464 |
Abdominal discomfort | 171.67 | 12.14 | 147 | 164246 | 214511 | 70549540 |
Radiation pneumonitis | 169.33 | 12.14 | 106 | 164287 | 3587 | 70760464 |
Product use issue | 168.91 | 12.14 | 104 | 164289 | 179833 | 70584218 |
Hypertension | 167.43 | 12.14 | 1217 | 163176 | 294816 | 70469235 |
Swelling | 166.12 | 12.14 | 117 | 164276 | 188422 | 70575629 |
Peripheral swelling | 165.99 | 12.14 | 182 | 164211 | 236381 | 70527670 |
Sense of oppression | 165.51 | 12.14 | 77 | 164316 | 1413 | 70762638 |
Suicide attempt | 165.06 | 12.14 | 4 | 164389 | 79506 | 70684545 |
Epistaxis | 164.60 | 12.14 | 568 | 163825 | 102059 | 70661992 |
Nasopharyngitis | 162.58 | 12.14 | 165 | 164228 | 222041 | 70542010 |
Systemic lupus erythematosus | 159.75 | 12.14 | 23 | 164370 | 101879 | 70662172 |
Drug intolerance | 159.04 | 12.14 | 173 | 164220 | 225514 | 70538537 |
Psoriasis | 154.81 | 12.14 | 22 | 164371 | 98411 | 70665640 |
Somnolence | 152.22 | 12.14 | 165 | 164228 | 215441 | 70548610 |
Embolism | 149.29 | 12.14 | 167 | 164226 | 12821 | 70751230 |
Paraesthesia | 148.03 | 12.14 | 699 | 163694 | 144838 | 70619213 |
Mobility decreased | 146.63 | 12.14 | 30 | 164363 | 102969 | 70661082 |
Lymphangiosis carcinomatosa | 144.85 | 12.14 | 76 | 164317 | 1825 | 70762226 |
Hypersensitivity | 141.69 | 12.14 | 965 | 163428 | 228847 | 70535204 |
Cardiac dysfunction | 141.09 | 12.14 | 93 | 164300 | 3444 | 70760607 |
Oxygen saturation decreased | 137.79 | 12.14 | 585 | 163808 | 115844 | 70648207 |
Ovarian cancer recurrent | 137.39 | 12.14 | 50 | 164343 | 471 | 70763580 |
Confusional state | 137.31 | 12.14 | 283 | 164110 | 284115 | 70479936 |
Metastases to meninges | 136.25 | 12.14 | 87 | 164306 | 3049 | 70761002 |
Non-small cell lung cancer | 136.22 | 12.14 | 115 | 164278 | 6232 | 70757819 |
Intentional product misuse | 134.47 | 12.14 | 14 | 164379 | 79581 | 70684470 |
Abdominal pain | 133.43 | 12.14 | 1294 | 163099 | 340833 | 70423218 |
Hospitalisation | 133.31 | 12.14 | 17 | 164376 | 82551 | 70681500 |
Neutropenic sepsis | 129.97 | 12.14 | 218 | 164175 | 24612 | 70739439 |
Blood cholesterol increased | 127.80 | 12.14 | 5 | 164388 | 64599 | 70699452 |
Throat tightness | 124.78 | 12.14 | 215 | 164178 | 24807 | 70739244 |
Insomnia | 124.63 | 12.14 | 195 | 164198 | 217611 | 70546440 |
Contusion | 124.36 | 12.14 | 71 | 164322 | 127965 | 70636086 |
Dehydration | 123.93 | 12.14 | 923 | 163470 | 225219 | 70538832 |
Ovarian cancer | 123.62 | 12.14 | 91 | 164302 | 4034 | 70760017 |
Decreased appetite | 122.88 | 12.14 | 1161 | 163232 | 303619 | 70460432 |
Hypoxia | 122.28 | 12.14 | 484 | 163909 | 92860 | 70671191 |
Plasma cell myeloma | 120.81 | 12.14 | 14 | 164379 | 73187 | 70690864 |
Asthma | 120.19 | 12.14 | 65 | 164328 | 120728 | 70643323 |
Nail toxicity | 119.52 | 12.14 | 41 | 164352 | 319 | 70763732 |
Arthritis | 119.49 | 12.14 | 39 | 164354 | 97941 | 70666110 |
Pulmonary embolism | 118.09 | 12.14 | 690 | 163703 | 155177 | 70608874 |
Pancytopenia | 117.78 | 12.14 | 674 | 163719 | 150433 | 70613618 |
Influenza | 116.35 | 12.14 | 59 | 164334 | 113641 | 70650410 |
Migraine | 116.31 | 12.14 | 15 | 164378 | 72223 | 70691828 |
Loss of personal independence in daily activities | 116.26 | 12.14 | 27 | 164366 | 84883 | 70679168 |
Cyanosis | 115.20 | 12.14 | 199 | 164194 | 23007 | 70741044 |
Helicobacter infection | 114.76 | 12.14 | 3 | 164390 | 55653 | 70708398 |
Pneumothorax | 114.65 | 12.14 | 211 | 164182 | 25635 | 70738416 |
Hypoglycaemia | 114.30 | 12.14 | 38 | 164355 | 94326 | 70669725 |
Hepatic enzyme increased | 114.30 | 12.14 | 117 | 164276 | 156873 | 70607178 |
Gastrointestinal toxicity | 113.33 | 12.14 | 104 | 164289 | 6301 | 70757750 |
Wound | 112.39 | 12.14 | 44 | 164349 | 98688 | 70665363 |
Recall phenomenon | 112.30 | 12.14 | 53 | 164340 | 1006 | 70763045 |
Tumour haemorrhage | 111.30 | 12.14 | 82 | 164311 | 3640 | 70760411 |
Osteonecrosis of jaw | 110.22 | 12.14 | 273 | 164120 | 40729 | 70723322 |
Metastases to skin | 108.98 | 12.14 | 59 | 164334 | 1512 | 70762539 |
Thrombotic microangiopathy | 108.87 | 12.14 | 168 | 164225 | 17680 | 70746371 |
Tachycardia | 107.52 | 12.14 | 682 | 163711 | 157864 | 70606187 |
Bone pain | 105.95 | 12.14 | 308 | 164085 | 50514 | 70713537 |
Breast cancer recurrent | 105.53 | 12.14 | 71 | 164322 | 2722 | 70761329 |
Injection site erythema | 104.29 | 12.14 | 21 | 164372 | 72903 | 70691148 |
Immune-mediated hepatitis | 103.87 | 12.14 | 71 | 164322 | 2795 | 70761256 |
Blood pressure fluctuation | 103.33 | 12.14 | 9 | 164384 | 59003 | 70705048 |
Nail disorder | 103.00 | 12.14 | 124 | 164269 | 10300 | 70753751 |
Treatment failure | 98.74 | 12.14 | 113 | 164280 | 144029 | 70620022 |
Coronary artery disease | 98.69 | 12.14 | 14 | 164379 | 62722 | 70701329 |
Drug reaction with eosinophilia and systemic symptoms | 98.52 | 12.14 | 10 | 164383 | 58003 | 70706048 |
Inappropriate schedule of product administration | 98.37 | 12.14 | 64 | 164329 | 107491 | 70656560 |
Duodenal ulcer perforation | 97.68 | 12.14 | 5 | 164388 | 51107 | 70712944 |
Pericarditis | 97.65 | 12.14 | 37 | 164356 | 84668 | 70679383 |
Irritable bowel syndrome | 97.10 | 12.14 | 5 | 164388 | 50845 | 70713206 |
Alopecia | 96.45 | 12.14 | 788 | 163605 | 197702 | 70566349 |
Gait disturbance | 94.63 | 12.14 | 178 | 164215 | 184928 | 70579123 |
Fibromyalgia | 93.70 | 12.14 | 4 | 164389 | 47870 | 70716181 |
Anaphylactic reaction | 92.80 | 12.14 | 382 | 164011 | 74592 | 70689459 |
Cardiotoxicity | 92.35 | 12.14 | 121 | 164272 | 10949 | 70753102 |
Intestinal perforation | 92.28 | 12.14 | 147 | 164246 | 15897 | 70748154 |
Memory impairment | 91.94 | 12.14 | 50 | 164343 | 92591 | 70671460 |
Feeling abnormal | 91.73 | 12.14 | 117 | 164276 | 142202 | 70621849 |
Colitis | 91.03 | 12.14 | 340 | 164053 | 63474 | 70700577 |
Nail discolouration | 90.94 | 12.14 | 64 | 164329 | 2642 | 70761409 |
Bradycardia | 90.55 | 12.14 | 93 | 164300 | 124522 | 70639529 |
Ileus | 90.53 | 12.14 | 184 | 164209 | 24053 | 70739998 |
Hallucination | 90.13 | 12.14 | 32 | 164361 | 76228 | 70687823 |
Suicidal ideation | 89.75 | 12.14 | 25 | 164368 | 69571 | 70694480 |
Peripheral motor neuropathy | 89.17 | 12.14 | 67 | 164326 | 3065 | 70760986 |
Blister | 89.00 | 12.14 | 62 | 164331 | 100464 | 70663587 |
Asthenia | 88.19 | 12.14 | 1520 | 162873 | 456146 | 70307905 |
Injection site swelling | 86.53 | 12.14 | 3 | 164390 | 43154 | 70720897 |
Triple negative breast cancer | 86.31 | 12.14 | 27 | 164366 | 151 | 70763900 |
Drug hypersensitivity | 86.27 | 12.14 | 315 | 164078 | 262144 | 70501907 |
Myocardial infarction | 85.16 | 12.14 | 168 | 164225 | 171477 | 70592574 |
Performance status decreased | 83.99 | 12.14 | 83 | 164310 | 5518 | 70758533 |
Injection site reaction | 83.61 | 12.14 | 9 | 164384 | 49843 | 70714208 |
Hypokalaemia | 82.62 | 12.14 | 554 | 163839 | 130634 | 70633417 |
Coma | 82.17 | 12.14 | 56 | 164337 | 91788 | 70672263 |
Immune-mediated enterocolitis | 82.06 | 12.14 | 67 | 164326 | 3464 | 70760587 |
Exposure during pregnancy | 81.85 | 12.14 | 51 | 164342 | 87666 | 70676385 |
Dysaesthesia | 81.33 | 12.14 | 80 | 164313 | 5288 | 70758763 |
Radiation oesophagitis | 81.17 | 12.14 | 36 | 164357 | 588 | 70763463 |
Anxiety | 80.18 | 12.14 | 253 | 164140 | 220077 | 70543974 |
Metastasis | 79.68 | 12.14 | 84 | 164309 | 6030 | 70758021 |
Injury | 79.49 | 12.14 | 26 | 164367 | 65219 | 70698832 |
Tumour necrosis | 79.21 | 12.14 | 50 | 164343 | 1717 | 70762334 |
Incorrect dose administered | 78.84 | 12.14 | 28 | 164365 | 66691 | 70697360 |
Electrocardiogram QT prolonged | 78.70 | 12.14 | 48 | 164345 | 83469 | 70680582 |
Sepsis | 78.25 | 12.14 | 889 | 163504 | 243656 | 70520395 |
Fluid retention | 77.68 | 12.14 | 25 | 164368 | 63360 | 70700691 |
Injection site pruritus | 77.67 | 12.14 | 3 | 164390 | 39207 | 70724844 |
Dizziness | 77.58 | 12.14 | 695 | 163698 | 463446 | 70300605 |
PIK3CA-activated mutation | 77.52 | 12.14 | 34 | 164359 | 540 | 70763511 |
Hepatic atrophy | 76.42 | 12.14 | 31 | 164362 | 401 | 70763650 |
C-reactive protein abnormal | 76.25 | 12.14 | 3 | 164390 | 38576 | 70725475 |
Rhabdomyolysis | 75.98 | 12.14 | 66 | 164327 | 95694 | 70668357 |
Tumour marker increased | 75.84 | 12.14 | 66 | 164327 | 3728 | 70760323 |
Metastatic neoplasm | 75.56 | 12.14 | 72 | 164321 | 4576 | 70759475 |
Urogenital fistula | 74.53 | 12.14 | 23 | 164370 | 122 | 70763929 |
Acute promyelocytic leukaemia | 73.65 | 12.14 | 45 | 164348 | 1457 | 70762594 |
Invasive ductal breast carcinoma | 72.50 | 12.14 | 78 | 164315 | 5731 | 70758320 |
Metastases to kidney | 72.41 | 12.14 | 31 | 164362 | 463 | 70763588 |
Serotonin syndrome | 72.19 | 12.14 | 7 | 164386 | 42107 | 70721944 |
Osteoarthritis | 72.15 | 12.14 | 41 | 164352 | 74106 | 70689945 |
Discomfort | 71.82 | 12.14 | 83 | 164310 | 105353 | 70658698 |
Lactic acidosis | 70.73 | 12.14 | 31 | 164362 | 64993 | 70699058 |
Pneumocystis jirovecii pneumonia | 70.24 | 12.14 | 190 | 164203 | 29892 | 70734159 |
International normalised ratio increased | 69.87 | 12.14 | 51 | 164342 | 80675 | 70683376 |
Muscle spasms | 69.54 | 12.14 | 159 | 164234 | 153887 | 70610164 |
Pain in extremity | 69.47 | 12.14 | 460 | 163933 | 327622 | 70436429 |
Nasal congestion | 68.80 | 12.14 | 33 | 164360 | 65639 | 70698412 |
Subileus | 68.45 | 12.14 | 72 | 164321 | 5155 | 70758896 |
Posterior reversible encephalopathy syndrome | 68.26 | 12.14 | 165 | 164228 | 24237 | 70739814 |
Large intestine perforation | 67.92 | 12.14 | 115 | 164278 | 13080 | 70750971 |
Alveolitis | 67.66 | 12.14 | 62 | 164331 | 3749 | 70760302 |
Aggression | 67.12 | 12.14 | 15 | 164378 | 48431 | 70715620 |
Nephrolithiasis | 66.89 | 12.14 | 14 | 164379 | 47309 | 70716742 |
Stomatitis | 66.10 | 12.14 | 517 | 163876 | 127994 | 70636057 |
Lower respiratory tract infection | 66.08 | 12.14 | 98 | 164295 | 111815 | 70652236 |
Macular oedema | 65.64 | 12.14 | 70 | 164323 | 5092 | 70758959 |
Malignant pleural effusion | 65.57 | 12.14 | 56 | 164337 | 3083 | 70760968 |
Metastases to spine | 65.47 | 12.14 | 61 | 164332 | 3768 | 70760283 |
Cataract | 64.65 | 12.14 | 24 | 164369 | 55621 | 70708430 |
Enterocolitis infectious | 64.47 | 12.14 | 52 | 164341 | 2642 | 70761409 |
Scleroderma-like reaction | 64.36 | 12.14 | 20 | 164373 | 109 | 70763942 |
Nail dystrophy | 64.09 | 12.14 | 35 | 164358 | 913 | 70763138 |
Pulmonary arterial hypertension | 63.46 | 12.14 | 3 | 164390 | 32852 | 70731199 |
Cardiac failure congestive | 63.44 | 12.14 | 137 | 164256 | 135320 | 70628731 |
Metastases to the mediastinum | 63.19 | 12.14 | 29 | 164364 | 515 | 70763536 |
Urticaria | 63.05 | 12.14 | 182 | 164211 | 162867 | 70601184 |
Bronchial fistula | 62.85 | 12.14 | 22 | 164371 | 183 | 70763868 |
Computerised tomogram thorax abnormal | 62.23 | 12.14 | 46 | 164347 | 2052 | 70761999 |
Anaphylactoid reaction | 62.08 | 12.14 | 67 | 164326 | 4940 | 70759111 |
Haemoptysis | 61.19 | 12.14 | 259 | 164134 | 51193 | 70712858 |
Illness | 61.10 | 12.14 | 3 | 164390 | 31788 | 70732263 |
COVID-19 | 61.09 | 12.14 | 94 | 164299 | 105663 | 70658388 |
Cholangitis sclerosing | 60.95 | 12.14 | 47 | 164346 | 2236 | 70761815 |
Metabolic acidosis | 60.50 | 12.14 | 50 | 164343 | 74296 | 70689755 |
Hyperaemia | 59.84 | 12.14 | 51 | 164342 | 2800 | 70761251 |
Accidental overdose | 59.77 | 12.14 | 6 | 164387 | 35115 | 70728936 |
Bronchitis | 59.66 | 12.14 | 113 | 164280 | 117130 | 70646921 |
Basal cell carcinoma | 59.38 | 12.14 | 5 | 164388 | 33693 | 70730358 |
Hypertensive crisis | 59.05 | 12.14 | 135 | 164258 | 19127 | 70744924 |
Irritability | 59.03 | 12.14 | 9 | 164384 | 38216 | 70725835 |
Cardiomyopathy | 59.02 | 12.14 | 164 | 164229 | 26209 | 70737842 |
Oesophagitis | 58.95 | 12.14 | 149 | 164244 | 22503 | 70741548 |
Acute interstitial pneumonitis | 58.94 | 12.14 | 35 | 164358 | 1075 | 70762976 |
Osteoporosis | 58.68 | 12.14 | 20 | 164373 | 48887 | 70715164 |
Metastases to pleura | 58.34 | 12.14 | 37 | 164356 | 1281 | 70762770 |
Pulmonary toxicity | 58.10 | 12.14 | 96 | 164297 | 10702 | 70753349 |
Immune-mediated lung disease | 57.58 | 12.14 | 40 | 164353 | 1617 | 70762434 |
Sleep apnoea syndrome | 57.24 | 12.14 | 5 | 164388 | 32708 | 70731343 |
Prostate cancer | 56.67 | 12.14 | 4 | 164389 | 31159 | 70732892 |
Bronchostenosis | 56.33 | 12.14 | 28 | 164365 | 598 | 70763453 |
Product prescribing error | 56.14 | 12.14 | 11 | 164382 | 38941 | 70725110 |
Hepatic failure | 55.79 | 12.14 | 273 | 164120 | 57352 | 70706699 |
Lymphoedema | 55.72 | 12.14 | 96 | 164297 | 11073 | 70752978 |
Secondary cerebellar degeneration | 55.35 | 12.14 | 15 | 164378 | 45 | 70764006 |
Stress | 54.94 | 12.14 | 46 | 164347 | 67920 | 70696131 |
Eosinophilia | 54.83 | 12.14 | 13 | 164380 | 40306 | 70723745 |
Maternal exposure during pregnancy | 54.56 | 12.14 | 116 | 164277 | 115229 | 70648822 |
Suffocation feeling | 54.05 | 12.14 | 38 | 164355 | 1566 | 70762485 |
Malignant ascites | 54.03 | 12.14 | 33 | 164360 | 1068 | 70762983 |
Acute myelomonocytic leukaemia | 54.00 | 12.14 | 22 | 164371 | 288 | 70763763 |
Disseminated intravascular coagulation | 53.86 | 12.14 | 186 | 164207 | 33412 | 70730639 |
Cytomegalovirus infection | 53.71 | 12.14 | 13 | 164380 | 39745 | 70724306 |
Paronychia | 52.43 | 12.14 | 73 | 164320 | 7001 | 70757050 |
Palmar erythema | 52.29 | 12.14 | 39 | 164354 | 1764 | 70762287 |
Medication error | 51.84 | 12.14 | 34 | 164359 | 56878 | 70707173 |
Biliary sepsis | 51.67 | 12.14 | 36 | 164357 | 1462 | 70762589 |
Drug level increased | 51.11 | 12.14 | 11 | 164382 | 36458 | 70727593 |
Treatment noncompliance | 50.98 | 12.14 | 22 | 164371 | 46552 | 70717499 |
Left ventricular dysfunction | 50.84 | 12.14 | 122 | 164271 | 17835 | 70746216 |
Carbohydrate antigen 125 increased | 50.67 | 12.14 | 40 | 164353 | 1970 | 70762081 |
Swollen tongue | 50.27 | 12.14 | 12 | 164381 | 37034 | 70727017 |
Hot flush | 50.24 | 12.14 | 238 | 164155 | 49346 | 70714705 |
Wrong technique in product usage process | 50.20 | 12.14 | 51 | 164342 | 68647 | 70695404 |
Atelectasis | 49.66 | 12.14 | 164 | 164229 | 28798 | 70735253 |
Road traffic accident | 49.56 | 12.14 | 10 | 164383 | 34672 | 70729379 |
Oesophagobronchial fistula | 48.96 | 12.14 | 19 | 164374 | 217 | 70763834 |
Unevaluable event | 48.94 | 12.14 | 30 | 164363 | 52033 | 70712018 |
Dyskinesia | 48.93 | 12.14 | 17 | 164376 | 41057 | 70722994 |
Hepatic function abnormal | 48.86 | 12.14 | 297 | 164096 | 67699 | 70696352 |
Pericardial effusion | 48.67 | 12.14 | 209 | 164184 | 41567 | 70722484 |
Carbohydrate antigen 15-3 increased | 47.58 | 12.14 | 30 | 164363 | 1028 | 70763023 |
Laryngospasm | 47.38 | 12.14 | 50 | 164343 | 3593 | 70760458 |
Device related infection | 47.15 | 12.14 | 173 | 164220 | 32012 | 70732039 |
Tumour lysis syndrome | 46.98 | 12.14 | 132 | 164261 | 21228 | 70742823 |
Wheezing | 46.83 | 12.14 | 92 | 164301 | 94078 | 70669973 |
Gastric disorder | 46.80 | 12.14 | 10 | 164383 | 33312 | 70730739 |
Febrile infection | 46.48 | 12.14 | 46 | 164347 | 3063 | 70760988 |
Blood glucose increased | 45.89 | 12.14 | 107 | 164286 | 102875 | 70661176 |
Small intestinal perforation | 45.88 | 12.14 | 45 | 164348 | 2964 | 70761087 |
Haemolytic uraemic syndrome | 45.58 | 12.14 | 52 | 164341 | 4078 | 70759973 |
Adrenocorticotropic hormone deficiency | 45.35 | 12.14 | 29 | 164364 | 1019 | 70763032 |
Superior vena cava syndrome | 45.34 | 12.14 | 30 | 164363 | 1118 | 70762933 |
Folliculitis | 45.19 | 12.14 | 21 | 164372 | 42549 | 70721502 |
Immune-mediated hepatic disorder | 44.92 | 12.14 | 28 | 164365 | 940 | 70763111 |
Limb injury | 44.88 | 12.14 | 4 | 164389 | 25748 | 70738303 |
Liver abscess | 44.85 | 12.14 | 60 | 164333 | 5539 | 70758512 |
Extravasation | 44.85 | 12.14 | 47 | 164346 | 3350 | 70760701 |
Stress cardiomyopathy | 44.35 | 12.14 | 81 | 164312 | 9781 | 70754270 |
Respiratory distress | 44.00 | 12.14 | 246 | 164147 | 54404 | 70709647 |
Choking sensation | 43.73 | 12.14 | 48 | 164345 | 3607 | 70760444 |
Immune-mediated dermatitis | 43.25 | 12.14 | 19 | 164374 | 303 | 70763748 |
Ear infection | 43.01 | 12.14 | 7 | 164386 | 28329 | 70735722 |
Type I hypersensitivity | 42.91 | 12.14 | 48 | 164345 | 3684 | 70760367 |
Neutropenic colitis | 42.82 | 12.14 | 56 | 164337 | 5058 | 70758993 |
Subdural haematoma | 42.81 | 12.14 | 8 | 164385 | 29290 | 70734761 |
Tumour associated fever | 42.75 | 12.14 | 25 | 164368 | 746 | 70763305 |
Psychotic disorder | 42.57 | 12.14 | 17 | 164376 | 37684 | 70726367 |
Tremor | 42.24 | 12.14 | 201 | 164192 | 155423 | 70608628 |
Full blood count abnormal | 42.15 | 12.14 | 13 | 164380 | 33865 | 70730186 |
Surgery | 42.12 | 12.14 | 9 | 164384 | 29980 | 70734071 |
Death | 42.08 | 12.14 | 1510 | 162883 | 508551 | 70255500 |
Abnormal behaviour | 41.98 | 12.14 | 14 | 164379 | 34695 | 70729356 |
Carcinoembryonic antigen increased | 41.96 | 12.14 | 36 | 164357 | 1994 | 70762057 |
Cachexia | 41.63 | 12.14 | 79 | 164314 | 9821 | 70754230 |
Angioedema | 41.62 | 12.14 | 56 | 164337 | 66554 | 70697497 |
Gastrooesophageal reflux disease | 41.59 | 12.14 | 93 | 164300 | 90746 | 70673305 |
Rash pruritic | 41.38 | 12.14 | 51 | 164342 | 62940 | 70701111 |
Oropharyngeal pain | 41.38 | 12.14 | 102 | 164291 | 96208 | 70667843 |
Hypersensitivity pneumonitis | 41.05 | 12.14 | 45 | 164348 | 3377 | 70760674 |
Rectal perforation | 41.01 | 12.14 | 25 | 164368 | 806 | 70763245 |
Head injury | 40.89 | 12.14 | 14 | 164379 | 34127 | 70729924 |
Blood creatine phosphokinase increased | 40.88 | 12.14 | 49 | 164344 | 61214 | 70702837 |
Poisoning | 40.86 | 12.14 | 3 | 164390 | 22619 | 70741432 |
Mental disorder | 40.65 | 12.14 | 8 | 164385 | 28232 | 70735819 |
Joint range of motion decreased | 40.48 | 12.14 | 6 | 164387 | 26020 | 70738031 |
Adenocarcinoma pancreas | 40.12 | 12.14 | 35 | 164358 | 1983 | 70762068 |
Hypomagnesaemia | 40.09 | 12.14 | 194 | 164199 | 40570 | 70723481 |
Recurrent cancer | 40.04 | 12.14 | 38 | 164355 | 2403 | 70761648 |
Drug withdrawal syndrome | 39.91 | 12.14 | 13 | 164380 | 32702 | 70731349 |
Transient ischaemic attack | 39.78 | 12.14 | 29 | 164364 | 45915 | 70718136 |
Adverse drug reaction | 39.66 | 12.14 | 39 | 164354 | 53305 | 70710746 |
Portal hypertension | 39.44 | 12.14 | 61 | 164332 | 6431 | 70757620 |
Hydronephrosis | 39.39 | 12.14 | 100 | 164293 | 15142 | 70748909 |
Female genital tract fistula | 39.31 | 12.14 | 42 | 164351 | 3061 | 70760990 |
Product administration error | 39.21 | 12.14 | 10 | 164383 | 29513 | 70734538 |
Cardiac disorder | 39.14 | 12.14 | 48 | 164345 | 59367 | 70704684 |
Labelled drug-drug interaction medication error | 38.86 | 12.14 | 5 | 164388 | 24122 | 70739929 |
Adenocarcinoma | 38.64 | 12.14 | 45 | 164348 | 3608 | 70760443 |
Nervousness | 38.62 | 12.14 | 12 | 164381 | 31108 | 70732943 |
Agitation | 38.49 | 12.14 | 101 | 164292 | 93274 | 70670777 |
Herpes zoster | 38.43 | 12.14 | 88 | 164305 | 85147 | 70678904 |
Eastern Cooperative Oncology Group performance status worsened | 38.40 | 12.14 | 31 | 164362 | 1577 | 70762474 |
Joint stiffness | 37.89 | 12.14 | 17 | 164376 | 35159 | 70728892 |
Eye pain | 37.49 | 12.14 | 16 | 164377 | 34086 | 70729965 |
Infusion related hypersensitivity reaction | 37.31 | 12.14 | 16 | 164377 | 240 | 70763811 |
Metastases to retroperitoneum | 37.24 | 12.14 | 18 | 164375 | 361 | 70763690 |
Capillary permeability increased | 37.15 | 12.14 | 10 | 164383 | 29 | 70764022 |
Nightmare | 37.15 | 12.14 | 4 | 164389 | 22152 | 70741899 |
Sleep disorder | 36.73 | 12.14 | 66 | 164327 | 69806 | 70694245 |
Haemorrhage | 36.61 | 12.14 | 88 | 164305 | 83727 | 70680324 |
Hypopituitarism | 36.40 | 12.14 | 40 | 164353 | 3010 | 70761041 |
Cervix carcinoma | 36.28 | 12.14 | 34 | 164359 | 2116 | 70761935 |
Acne | 36.13 | 12.14 | 7 | 164386 | 24982 | 70739069 |
Skin laceration | 35.87 | 12.14 | 8 | 164385 | 25870 | 70738181 |
Pulmonary radiation injury | 35.86 | 12.14 | 11 | 164382 | 57 | 70763994 |
Bone lesion | 35.79 | 12.14 | 53 | 164340 | 5377 | 70758674 |
Tracheal fistula | 35.67 | 12.14 | 13 | 164380 | 123 | 70763928 |
Acute myocardial infarction | 35.56 | 12.14 | 72 | 164321 | 72815 | 70691236 |
Capillary leak syndrome | 35.55 | 12.14 | 42 | 164351 | 3420 | 70760631 |
Type 2 diabetes mellitus | 35.42 | 12.14 | 30 | 164363 | 44050 | 70720001 |
Aortitis | 35.40 | 12.14 | 28 | 164365 | 1383 | 70762668 |
Computerised tomogram thorax | 35.28 | 12.14 | 15 | 164378 | 220 | 70763831 |
Injection site haemorrhage | 35.17 | 12.14 | 8 | 164385 | 25519 | 70738532 |
Hyperhidrosis | 34.93 | 12.14 | 462 | 163931 | 131124 | 70632927 |
Blood pressure systolic increased | 34.91 | 12.14 | 49 | 164344 | 57210 | 70706841 |
Acute kidney injury | 34.80 | 12.14 | 836 | 163557 | 473788 | 70290263 |
Dysgeusia | 34.79 | 12.14 | 215 | 164178 | 49287 | 70714764 |
Chills | 34.64 | 12.14 | 499 | 163894 | 144287 | 70619764 |
Prescribed overdose | 34.60 | 12.14 | 10 | 164383 | 27171 | 70736880 |
Dystonia | 34.51 | 12.14 | 3 | 164390 | 19703 | 70744348 |
Gait inability | 34.49 | 12.14 | 35 | 164358 | 47140 | 70716911 |
Blood triglycerides increased | 34.42 | 12.14 | 3 | 164390 | 19661 | 70744390 |
Toxic erythema of chemotherapy | 34.27 | 12.14 | 15 | 164378 | 237 | 70763814 |
Hyperkalaemia | 34.27 | 12.14 | 129 | 164264 | 106462 | 70657589 |
Gout | 34.22 | 12.14 | 6 | 164387 | 23000 | 70741051 |
Emotional distress | 34.16 | 12.14 | 22 | 164371 | 37166 | 70726885 |
Radiation skin injury | 34.09 | 12.14 | 27 | 164366 | 1336 | 70762715 |
Enterocolitis | 34.06 | 12.14 | 86 | 164307 | 12980 | 70751071 |
Heart rate decreased | 34.04 | 12.14 | 57 | 164336 | 61958 | 70702093 |
Pneumatosis intestinalis | 33.93 | 12.14 | 54 | 164339 | 5833 | 70758218 |
Metastases to stomach | 33.93 | 12.14 | 15 | 164378 | 243 | 70763808 |
Pseudomembranous colitis | 33.85 | 12.14 | 50 | 164343 | 5061 | 70758990 |
Drug ineffective for unapproved indication | 33.79 | 12.14 | 24 | 164369 | 38514 | 70725537 |
Amnesia | 33.46 | 12.14 | 43 | 164350 | 52112 | 70711939 |
Lymphadenopathy mediastinal | 33.41 | 12.14 | 44 | 164349 | 4001 | 70760050 |
Constipation | 33.34 | 12.14 | 793 | 163600 | 251645 | 70512406 |
Diabetes mellitus | 33.32 | 12.14 | 73 | 164320 | 71751 | 70692300 |
Incorrect route of product administration | 33.26 | 12.14 | 10 | 164383 | 26482 | 70737569 |
Device related thrombosis | 33.23 | 12.14 | 34 | 164359 | 2356 | 70761695 |
Small intestinal obstruction | 33.20 | 12.14 | 129 | 164264 | 24526 | 70739525 |
Eczema asteatotic | 32.82 | 12.14 | 19 | 164374 | 556 | 70763495 |
Cancer pain | 32.74 | 12.14 | 48 | 164345 | 4826 | 70759225 |
Crying | 32.71 | 12.14 | 5 | 164388 | 21194 | 70742857 |
Tonsillar disorder | 32.48 | 12.14 | 24 | 164369 | 1070 | 70762981 |
Upper respiratory tract infection | 32.48 | 12.14 | 86 | 164307 | 79188 | 70684863 |
Primary cardiac lymphoma | 32.05 | 12.14 | 9 | 164384 | 32 | 70764019 |
Obesity | 32.03 | 12.14 | 11 | 164382 | 26760 | 70737291 |
Bile duct stenosis | 31.94 | 12.14 | 30 | 164363 | 1872 | 70762179 |
Fear | 31.91 | 12.14 | 5 | 164388 | 20806 | 70743245 |
Hypersomnia | 31.81 | 12.14 | 5 | 164388 | 20759 | 70743292 |
Scleroderma | 31.80 | 12.14 | 48 | 164345 | 4953 | 70759098 |
Metastases to chest wall | 31.78 | 12.14 | 17 | 164376 | 425 | 70763626 |
Metastases to eye | 31.77 | 12.14 | 14 | 164379 | 225 | 70763826 |
Pleural neoplasm | 31.72 | 12.14 | 16 | 164377 | 353 | 70763698 |
Pregnancy | 31.68 | 12.14 | 8 | 164385 | 23773 | 70740278 |
Immune-mediated pancreatitis | 31.58 | 12.14 | 13 | 164380 | 175 | 70763876 |
Neck pain | 31.54 | 12.14 | 67 | 164326 | 66590 | 70697461 |
Anastomotic leak | 31.51 | 12.14 | 23 | 164370 | 1006 | 70763045 |
Retroperitoneal lymphadenopathy | 31.49 | 12.14 | 23 | 164370 | 1007 | 70763044 |
Malignant peritoneal neoplasm | 31.47 | 12.14 | 20 | 164373 | 695 | 70763356 |
Administration site extravasation | 31.32 | 12.14 | 24 | 164369 | 1131 | 70762920 |
Erythema multiforme | 31.31 | 12.14 | 97 | 164296 | 16467 | 70747584 |
Myoclonus | 31.23 | 12.14 | 11 | 164382 | 26344 | 70737707 |
Dermatitis acneiform | 31.16 | 12.14 | 66 | 164327 | 8879 | 70755172 |
Kounis syndrome | 31.15 | 12.14 | 39 | 164354 | 3372 | 70760679 |
Inflammation | 30.98 | 12.14 | 87 | 164306 | 78578 | 70685473 |
Adrenal insufficiency | 30.86 | 12.14 | 128 | 164265 | 25067 | 70738984 |
Hypoalbuminaemia | 30.76 | 12.14 | 106 | 164287 | 19016 | 70745035 |
Disease recurrence | 30.76 | 12.14 | 170 | 164223 | 37433 | 70726618 |
Hypervolaemia | 30.72 | 12.14 | 28 | 164365 | 39678 | 70724373 |
Flatulence | 30.66 | 12.14 | 26 | 164367 | 38155 | 70725896 |
Right ventricular failure | 30.64 | 12.14 | 7 | 164386 | 22267 | 70741784 |
Hyperpyrexia | 30.57 | 12.14 | 49 | 164344 | 5325 | 70758726 |
Endocarditis noninfective | 30.56 | 12.14 | 13 | 164380 | 191 | 70763860 |
Blood uric acid decreased | 30.51 | 12.14 | 24 | 164369 | 1176 | 70762875 |
Balance disorder | 30.34 | 12.14 | 107 | 164286 | 90021 | 70674030 |
Musculoskeletal disorder | 30.17 | 12.14 | 5 | 164388 | 19966 | 70744085 |
Metastases to pelvis | 30.16 | 12.14 | 18 | 164375 | 558 | 70763493 |
Duodenal perforation | 30.16 | 12.14 | 30 | 164363 | 2010 | 70762041 |
Bursitis | 30.16 | 12.14 | 12 | 164381 | 26661 | 70737390 |
Periarticular thenar erythema with onycholysis | 30.03 | 12.14 | 8 | 164385 | 22 | 70764029 |
Transaminases increased | 29.84 | 12.14 | 199 | 164194 | 46819 | 70717232 |
Right ventricular ejection fraction decreased | 29.77 | 12.14 | 9 | 164384 | 44 | 70764007 |
Pancreatic enzyme abnormality | 29.64 | 12.14 | 11 | 164382 | 110 | 70763941 |
Tumour pain | 29.45 | 12.14 | 30 | 164363 | 2068 | 70761983 |
Mood swings | 28.95 | 12.14 | 4 | 164389 | 18282 | 70745769 |
Deep vein thrombosis | 28.70 | 12.14 | 388 | 164005 | 110654 | 70653397 |
Angiosarcoma | 28.60 | 12.14 | 17 | 164376 | 523 | 70763528 |
Cerebrovascular accident | 28.42 | 12.14 | 205 | 164188 | 143265 | 70620786 |
Panic attack | 28.41 | 12.14 | 8 | 164385 | 22111 | 70741940 |
Urinary tract obstruction | 28.41 | 12.14 | 42 | 164351 | 4255 | 70759796 |
Laryngeal necrosis | 28.37 | 12.14 | 8 | 164385 | 29 | 70764022 |
Neoplasm recurrence | 28.21 | 12.14 | 40 | 164353 | 3901 | 70760150 |
Pulse absent | 28.17 | 12.14 | 65 | 164328 | 9265 | 70754786 |
Subclavian vein thrombosis | 28.10 | 12.14 | 31 | 164362 | 2343 | 70761708 |
Accidental exposure to product | 28.02 | 12.14 | 15 | 164378 | 28036 | 70736015 |
Metastases to bladder | 27.97 | 12.14 | 13 | 164380 | 238 | 70763813 |
Oligohydramnios | 27.94 | 12.14 | 36 | 164357 | 3204 | 70760847 |
Hepatotoxicity | 27.81 | 12.14 | 186 | 164207 | 43800 | 70720251 |
Diabetes mellitus inadequate control | 27.62 | 12.14 | 9 | 164384 | 22636 | 70741415 |
Respiratory tract congestion | 27.62 | 12.14 | 4 | 164389 | 17649 | 70746402 |
Delirium | 27.59 | 12.14 | 85 | 164308 | 74529 | 70689522 |
Peritonitis | 27.55 | 12.14 | 127 | 164266 | 26032 | 70738019 |
Ovarian failure | 27.53 | 12.14 | 17 | 164376 | 561 | 70763490 |
Foot deformity | 27.42 | 12.14 | 7 | 164386 | 20648 | 70743403 |
Neuromuscular toxicity | 27.39 | 12.14 | 12 | 164381 | 190 | 70763861 |
Ovarian cancer metastatic | 27.32 | 12.14 | 17 | 164376 | 569 | 70763482 |
Tumour embolism | 27.28 | 12.14 | 11 | 164382 | 140 | 70763911 |
Hepatic lesion | 27.20 | 12.14 | 50 | 164343 | 6067 | 70757984 |
Venous thrombosis limb | 27.18 | 12.14 | 40 | 164353 | 4035 | 70760016 |
Kidney infection | 26.99 | 12.14 | 6 | 164387 | 19449 | 70744602 |
Drug resistance | 26.92 | 12.14 | 166 | 164227 | 38024 | 70726027 |
Blood potassium increased | 26.74 | 12.14 | 15 | 164378 | 27311 | 70736740 |
Sopor | 26.73 | 12.14 | 20 | 164373 | 31247 | 70732804 |
Limb discomfort | 26.71 | 12.14 | 18 | 164375 | 29687 | 70734364 |
Abortion spontaneous | 26.69 | 12.14 | 14 | 164379 | 26465 | 70737586 |
Eosinophil percentage increased | 26.54 | 12.14 | 24 | 164369 | 1426 | 70762625 |
Viral infection | 26.37 | 12.14 | 30 | 164363 | 38361 | 70725690 |
Melaena | 26.37 | 12.14 | 57 | 164336 | 56298 | 70707753 |
Gastric perforation | 26.25 | 12.14 | 38 | 164355 | 3777 | 70760274 |
Cardiac cirrhosis | 26.21 | 12.14 | 12 | 164381 | 212 | 70763839 |
Status epilepticus | 26.19 | 12.14 | 12 | 164381 | 24514 | 70739537 |
Procedural pain | 26.13 | 12.14 | 5 | 164388 | 18004 | 70746047 |
Bone marrow infiltration | 26.13 | 12.14 | 16 | 164377 | 520 | 70763531 |
Seizure | 26.04 | 12.14 | 275 | 164118 | 177687 | 70586364 |
Lymphopenia | 26.04 | 12.14 | 129 | 164264 | 27230 | 70736821 |
Night sweats | 26.02 | 12.14 | 38 | 164355 | 43646 | 70720405 |
Enteritis | 26 | 12.14 | 77 | 164316 | 12754 | 70751297 |
Mastitis | 25.90 | 12.14 | 28 | 164365 | 2068 | 70761983 |
Dysphagia | 25.85 | 12.14 | 386 | 164007 | 112448 | 70651603 |
Septic shock | 25.70 | 12.14 | 384 | 164009 | 111874 | 70652177 |
Gallbladder disorder | 25.53 | 12.14 | 5 | 164388 | 17707 | 70746344 |
Blood pressure diastolic abnormal | 25.49 | 12.14 | 3 | 164390 | 15501 | 70748550 |
Wound dehiscence | 25.44 | 12.14 | 49 | 164344 | 6159 | 70757892 |
Thyroid dermatopathy | 25.35 | 12.14 | 7 | 164386 | 23 | 70764028 |
Foot fracture | 25.34 | 12.14 | 7 | 164386 | 19593 | 70744458 |
Metastatic gastric cancer | 25.23 | 12.14 | 14 | 164379 | 377 | 70763674 |
Therapy interrupted | 25.17 | 12.14 | 13 | 164380 | 24789 | 70739262 |
Tooth erosion | 25.07 | 12.14 | 14 | 164379 | 382 | 70763669 |
Chest pain | 25.06 | 12.14 | 761 | 163632 | 250499 | 70513552 |
Vocal cord paralysis | 25.04 | 12.14 | 29 | 164364 | 2312 | 70761739 |
Duodenitis haemorrhagic | 25.03 | 12.14 | 10 | 164383 | 124 | 70763927 |
Colitis ulcerative | 24.99 | 12.14 | 25 | 164368 | 33898 | 70730153 |
Gastritis bacterial | 24.97 | 12.14 | 13 | 164380 | 307 | 70763744 |
Acute megakaryocytic leukaemia | 24.96 | 12.14 | 8 | 164385 | 49 | 70764002 |
Tumour pseudoprogression | 24.87 | 12.14 | 16 | 164377 | 568 | 70763483 |
Therapeutic product effect incomplete | 24.86 | 12.14 | 169 | 164224 | 119713 | 70644338 |
Adverse event | 24.86 | 12.14 | 48 | 164345 | 49413 | 70714638 |
Sinus congestion | 24.84 | 12.14 | 5 | 164388 | 17368 | 70746683 |
Oesophagopleural fistula | 24.82 | 12.14 | 8 | 164385 | 50 | 70764001 |
Hepatic infection | 24.78 | 12.14 | 19 | 164374 | 896 | 70763155 |
Aplasia | 24.68 | 12.14 | 53 | 164340 | 7198 | 70756853 |
Paranoia | 24.67 | 12.14 | 5 | 164388 | 17283 | 70746768 |
Liver function test abnormal | 24.54 | 12.14 | 67 | 164326 | 61079 | 70702972 |
Sinus bradycardia | 24.54 | 12.14 | 12 | 164381 | 23611 | 70740440 |
Haemoglobin | 24.52 | 12.14 | 9 | 164384 | 87 | 70763964 |
Congestive cardiomyopathy | 24.50 | 12.14 | 68 | 164325 | 10858 | 70753193 |
Oligoastrocytoma | 24.49 | 12.14 | 7 | 164386 | 27 | 70764024 |
Pulmonary tumour thrombotic microangiopathy | 24.43 | 12.14 | 9 | 164384 | 88 | 70763963 |
Glaucoma | 24.27 | 12.14 | 6 | 164387 | 18086 | 70745965 |
Vena cava thrombosis | 24.09 | 12.14 | 30 | 164363 | 2580 | 70761471 |
Sinus disorder | 24.09 | 12.14 | 7 | 164386 | 18952 | 70745099 |
Eye disorder | 24.08 | 12.14 | 9 | 164384 | 20776 | 70743275 |
Device dislocation | 24.05 | 12.14 | 11 | 164382 | 22496 | 70741555 |
Movement disorder | 23.96 | 12.14 | 13 | 164380 | 24116 | 70739935 |
Lung abscess | 23.90 | 12.14 | 36 | 164357 | 3708 | 70760343 |
Weight decreased | 23.80 | 12.14 | 543 | 163850 | 309945 | 70454106 |
Localised infection | 23.79 | 12.14 | 25 | 164368 | 33133 | 70730918 |
Spinal stenosis | 23.69 | 12.14 | 3 | 164390 | 14650 | 70749401 |
Orthostatic hypotension | 23.66 | 12.14 | 53 | 164340 | 51690 | 70712361 |
Metastases to breast | 23.66 | 12.14 | 12 | 164381 | 268 | 70763783 |
Anaemia of malignant disease | 23.65 | 12.14 | 17 | 164376 | 726 | 70763325 |
Scintillating scotoma | 23.64 | 12.14 | 11 | 164382 | 202 | 70763849 |
Joint dislocation | 23.43 | 12.14 | 3 | 164390 | 14528 | 70749523 |
Intestinal metastasis | 23.14 | 12.14 | 12 | 164381 | 281 | 70763770 |
Tracheo-oesophageal fistula | 23.11 | 12.14 | 15 | 164378 | 541 | 70763510 |
Pruritus | 23.05 | 12.14 | 617 | 163776 | 344943 | 70419108 |
Eye swelling | 23.05 | 12.14 | 13 | 164380 | 23601 | 70740450 |
Exostosis | 23.03 | 12.14 | 3 | 164390 | 14342 | 70749709 |
Mood altered | 23.02 | 12.14 | 5 | 164388 | 16470 | 70747581 |
Uterine atrophy | 22.94 | 12.14 | 6 | 164387 | 15 | 70764036 |
Chromaturia | 22.90 | 12.14 | 13 | 164380 | 23515 | 70740536 |
Gastrointestinal haemorrhage | 22.77 | 12.14 | 206 | 164187 | 137202 | 70626849 |
Anhedonia | 22.76 | 12.14 | 3 | 164390 | 14210 | 70749841 |
Infected lymphocele | 22.56 | 12.14 | 11 | 164382 | 225 | 70763826 |
Pyogenic granuloma | 22.43 | 12.14 | 14 | 164379 | 471 | 70763580 |
Underdose | 22.40 | 12.14 | 21 | 164372 | 29362 | 70734689 |
Ovarian epithelial cancer recurrent | 22.39 | 12.14 | 6 | 164387 | 17 | 70764034 |
Extrapyramidal disorder | 22.39 | 12.14 | 10 | 164383 | 20740 | 70743311 |
Hallucination, visual | 22.33 | 12.14 | 21 | 164372 | 29316 | 70734735 |
Pulmonary cavitation | 22.32 | 12.14 | 22 | 164371 | 1458 | 70762593 |
No adverse event | 22.22 | 12.14 | 25 | 164368 | 32128 | 70731923 |
Teratoma benign | 22.21 | 12.14 | 8 | 164385 | 73 | 70763978 |
Metastases to soft tissue | 22.11 | 12.14 | 13 | 164380 | 392 | 70763659 |
Immune-mediated myocarditis | 22.08 | 12.14 | 16 | 164377 | 692 | 70763359 |
Gelastic seizure | 21.89 | 12.14 | 5 | 164388 | 5 | 70764046 |
Ductal adenocarcinoma of pancreas | 21.87 | 12.14 | 10 | 164383 | 176 | 70763875 |
Xerophthalmia | 21.84 | 12.14 | 15 | 164378 | 595 | 70763456 |
Faeces discoloured | 21.84 | 12.14 | 18 | 164375 | 26791 | 70737260 |
Hormone receptor positive breast cancer | 21.70 | 12.14 | 12 | 164381 | 321 | 70763730 |
Vaginal fistula | 21.67 | 12.14 | 11 | 164382 | 246 | 70763805 |
Poor quality sleep | 21.66 | 12.14 | 10 | 164383 | 20339 | 70743712 |
Dysarthria | 21.63 | 12.14 | 73 | 164320 | 62240 | 70701811 |
Dermatomyositis | 21.60 | 12.14 | 33 | 164360 | 3442 | 70760609 |
Intestinal obstruction | 21.51 | 12.14 | 159 | 164234 | 38666 | 70725385 |
Urinary retention | 21.49 | 12.14 | 57 | 164336 | 52463 | 70711588 |
Eye pruritus | 21.40 | 12.14 | 4 | 164389 | 14643 | 70749408 |
Ventricular tachycardia | 21.39 | 12.14 | 32 | 164361 | 36391 | 70727660 |
Speech disorder | 21.38 | 12.14 | 54 | 164339 | 50526 | 70713525 |
Therapy cessation | 21.36 | 12.14 | 28 | 164365 | 33648 | 70730403 |
Periodontitis | 21.33 | 12.14 | 37 | 164356 | 4291 | 70759760 |
Bronchopulmonary aspergillosis | 21.32 | 12.14 | 11 | 164382 | 20991 | 70743060 |
Nasal septum perforation | 21.27 | 12.14 | 16 | 164377 | 733 | 70763318 |
Thrombophlebitis migrans | 21.27 | 12.14 | 12 | 164381 | 334 | 70763717 |
Bronchopleural fistula | 21.23 | 12.14 | 15 | 164378 | 623 | 70763428 |
Arterioenteric fistula | 21.23 | 12.14 | 6 | 164387 | 22 | 70764029 |
Glycosylated haemoglobin increased | 21.06 | 12.14 | 7 | 164386 | 17384 | 70746667 |
Metastases to abdominal cavity | 21.03 | 12.14 | 14 | 164379 | 527 | 70763524 |
Device issue | 21.01 | 12.14 | 15 | 164378 | 24010 | 70740041 |
Cystitis noninfective | 20.99 | 12.14 | 20 | 164373 | 1271 | 70762780 |
Therapeutic response unexpected | 20.94 | 12.14 | 8 | 164385 | 18223 | 70745828 |
Rash papular | 20.90 | 12.14 | 8 | 164385 | 18202 | 70745849 |
Endometrial adenocarcinoma | 20.87 | 12.14 | 18 | 164375 | 1004 | 70763047 |
Acquired gene mutation | 20.80 | 12.14 | 25 | 164368 | 2073 | 70761978 |
Acute erythroid leukaemia | 20.78 | 12.14 | 11 | 164382 | 269 | 70763782 |
Ocular hyperaemia | 20.75 | 12.14 | 16 | 164377 | 24623 | 70739428 |
Muscle twitching | 20.71 | 12.14 | 10 | 164383 | 19817 | 70744234 |
Tongue disorder | 20.69 | 12.14 | 3 | 164390 | 13224 | 70750827 |
Taeniasis | 20.69 | 12.14 | 7 | 164386 | 52 | 70763999 |
Gastrointestinal necrosis | 20.49 | 12.14 | 40 | 164353 | 5078 | 70758973 |
Transfusion | 20.45 | 12.14 | 9 | 164384 | 18827 | 70745224 |
Pulmonary congestion | 20.36 | 12.14 | 17 | 164376 | 25137 | 70738914 |
Hip arthroplasty | 20.27 | 12.14 | 21 | 164372 | 28019 | 70736032 |
Splenic artery thrombosis | 20.24 | 12.14 | 7 | 164386 | 56 | 70763995 |
Hypocalcaemia | 20.10 | 12.14 | 175 | 164218 | 44684 | 70719367 |
Chronic obstructive pulmonary disease | 20.06 | 12.14 | 102 | 164291 | 77539 | 70686512 |
Fungal infection | 20.04 | 12.14 | 35 | 164358 | 37432 | 70726619 |
Pancreatic failure | 19.97 | 12.14 | 21 | 164372 | 1503 | 70762548 |
Immune-mediated nephritis | 19.96 | 12.14 | 12 | 164381 | 377 | 70763674 |
Respiratory depth decreased | 19.90 | 12.14 | 6 | 164387 | 29 | 70764022 |
Vessel puncture site bruise | 19.90 | 12.14 | 13 | 164380 | 474 | 70763577 |
Aortic injury | 19.88 | 12.14 | 5 | 164388 | 10 | 70764041 |
Blood urine present | 19.85 | 12.14 | 10 | 164383 | 19343 | 70744708 |
Pancreatic carcinoma recurrent | 19.81 | 12.14 | 9 | 164384 | 156 | 70763895 |
Neuroendocrine breast tumour | 19.74 | 12.14 | 6 | 164387 | 30 | 70764021 |
Nail avulsion | 19.69 | 12.14 | 8 | 164385 | 104 | 70763947 |
Impaired healing | 19.62 | 12.14 | 97 | 164296 | 74277 | 70689774 |
Ovarian epithelial cancer | 19.61 | 12.14 | 10 | 164383 | 226 | 70763825 |
Cough | 19.59 | 12.14 | 932 | 163461 | 324445 | 70439606 |
Upper gastrointestinal perforation | 19.56 | 12.14 | 5 | 164388 | 11 | 70764040 |
Radiation necrosis | 19.55 | 12.14 | 12 | 164381 | 392 | 70763659 |
Post thrombotic syndrome | 19.49 | 12.14 | 14 | 164379 | 597 | 70763454 |
Oesophageal stenosis | 19.43 | 12.14 | 34 | 164359 | 3970 | 70760081 |
Pulmonary artery stenosis | 19.41 | 12.14 | 8 | 164385 | 108 | 70763943 |
Lung adenocarcinoma | 19.40 | 12.14 | 50 | 164343 | 7640 | 70756411 |
Device malfunction | 19.37 | 12.14 | 10 | 164383 | 19074 | 70744977 |
Infectious pleural effusion | 19.31 | 12.14 | 30 | 164363 | 3174 | 70760877 |
Gastroenteritis viral | 19.29 | 12.14 | 13 | 164380 | 21442 | 70742609 |
Biliary obstruction | 19.29 | 12.14 | 34 | 164359 | 3993 | 70760058 |
Renal failure | 19.27 | 12.14 | 315 | 164078 | 188755 | 70575296 |
Cholangitis infective | 19.24 | 12.14 | 13 | 164380 | 502 | 70763549 |
Carbohydrate antigen 19-9 increased | 19.20 | 12.14 | 12 | 164381 | 405 | 70763646 |
Dysstasia | 19.19 | 12.14 | 18 | 164375 | 25161 | 70738890 |
Joint effusion | 19.15 | 12.14 | 6 | 164387 | 15471 | 70748580 |
Hypermetabolism | 19.12 | 12.14 | 11 | 164382 | 318 | 70763733 |
Guillain-Barre syndrome | 18.99 | 12.14 | 51 | 164342 | 7989 | 70756062 |
Immediate post-injection reaction | 18.97 | 12.14 | 11 | 164382 | 323 | 70763728 |
Dyspnoea at rest | 18.95 | 12.14 | 46 | 164347 | 6773 | 70757278 |
Lymphatic disorder | 18.94 | 12.14 | 11 | 164382 | 324 | 70763727 |
Cholelithiasis | 18.90 | 12.14 | 52 | 164341 | 47288 | 70716763 |
Musculoskeletal pain | 18.90 | 12.14 | 127 | 164266 | 90200 | 70673851 |
Haematochezia | 18.89 | 12.14 | 96 | 164297 | 72985 | 70691066 |
Disturbance in attention | 18.76 | 12.14 | 45 | 164348 | 42849 | 70721202 |
Carpal tunnel syndrome | 18.76 | 12.14 | 8 | 164385 | 17049 | 70747002 |
Emphysematous cystitis | 18.69 | 12.14 | 10 | 164383 | 250 | 70763801 |
Angiodermatitis | 18.69 | 12.14 | 7 | 164386 | 72 | 70763979 |
Swelling face | 18.68 | 12.14 | 79 | 164314 | 63085 | 70700966 |
Photophobia | 18.59 | 12.14 | 10 | 164383 | 18640 | 70745411 |
Muscle rigidity | 18.59 | 12.14 | 10 | 164383 | 18640 | 70745411 |
Cardiac murmur | 18.52 | 12.14 | 3 | 164390 | 12183 | 70751868 |
Pain in jaw | 18.47 | 12.14 | 45 | 164348 | 42624 | 70721427 |
Epstein-Barr virus infection | 18.45 | 12.14 | 4 | 164389 | 13194 | 70750857 |
Ill-defined disorder | 18.41 | 12.14 | 65 | 164328 | 54676 | 70709375 |
Tumour ulceration | 18.38 | 12.14 | 9 | 164384 | 186 | 70763865 |
Transaminases | 18.35 | 12.14 | 7 | 164386 | 76 | 70763975 |
Depressed level of consciousness | 18.25 | 12.14 | 123 | 164270 | 87308 | 70676743 |
Dementia | 18.24 | 12.14 | 15 | 164378 | 22350 | 70741701 |
HER2 positive breast cancer | 18.18 | 12.14 | 11 | 164382 | 350 | 70763701 |
Laryngeal discomfort | 18.11 | 12.14 | 13 | 164380 | 554 | 70763497 |
Pneumonitis chemical | 18.09 | 12.14 | 11 | 164382 | 353 | 70763698 |
Immune-mediated encephalitis | 18.06 | 12.14 | 11 | 164382 | 354 | 70763697 |
Scar | 18.06 | 12.14 | 5 | 164388 | 13976 | 70750075 |
Immune reconstitution inflammatory syndrome | 18.04 | 12.14 | 4 | 164389 | 12986 | 70751065 |
Gastroenteritis radiation | 18.03 | 12.14 | 14 | 164379 | 673 | 70763378 |
Thyroiditis | 17.96 | 12.14 | 33 | 164360 | 4003 | 70760048 |
Hypothalamo-pituitary disorder | 17.87 | 12.14 | 17 | 164376 | 1078 | 70762973 |
Loss of consciousness | 17.83 | 12.14 | 480 | 163913 | 155236 | 70608815 |
Torsade de pointes | 17.64 | 12.14 | 10 | 164383 | 18106 | 70745945 |
Lung adenocarcinoma stage IV | 17.60 | 12.14 | 11 | 164382 | 371 | 70763680 |
Venous thrombosis | 17.58 | 12.14 | 44 | 164349 | 6605 | 70757446 |
Blood glucose decreased | 17.57 | 12.14 | 18 | 164375 | 24141 | 70739910 |
Empyema | 17.57 | 12.14 | 32 | 164361 | 3855 | 70760196 |
Sputum discoloured | 17.52 | 12.14 | 11 | 164382 | 18840 | 70745211 |
Breast sarcoma | 17.52 | 12.14 | 4 | 164389 | 4 | 70764047 |
Maternal death affecting foetus | 17.52 | 12.14 | 4 | 164389 | 4 | 70764047 |
Gene mutation | 17.51 | 12.14 | 24 | 164369 | 2267 | 70761784 |
Product supply issue | 17.46 | 12.14 | 20 | 164373 | 1575 | 70762476 |
Atrioventricular block first degree | 17.46 | 12.14 | 3 | 164390 | 11670 | 70752381 |
Liver scan abnormal | 17.46 | 12.14 | 6 | 164387 | 47 | 70764004 |
Vulvovaginal inflammation | 17.38 | 12.14 | 12 | 164381 | 480 | 70763571 |
Taste disorder | 17.36 | 12.14 | 62 | 164331 | 11323 | 70752728 |
Product storage error | 17.35 | 12.14 | 6 | 164387 | 14535 | 70749516 |
Blood pressure immeasurable | 17.32 | 12.14 | 22 | 164371 | 1930 | 70762121 |
Haematoma | 17.30 | 12.14 | 56 | 164337 | 48362 | 70715689 |
Chemotherapy | 17.25 | 12.14 | 20 | 164373 | 1596 | 70762455 |
Lymphadenopathy | 17.23 | 12.14 | 181 | 164212 | 48610 | 70715441 |
Sciatica | 17.18 | 12.14 | 19 | 164374 | 24608 | 70739443 |
Blast cells present | 17.15 | 12.14 | 15 | 164378 | 853 | 70763198 |
Hypophysitis | 17.07 | 12.14 | 31 | 164362 | 3727 | 70760324 |
Hypophagia | 17.01 | 12.14 | 159 | 164234 | 41411 | 70722640 |
Non-small cell lung cancer stage IV | 16.99 | 12.14 | 10 | 164383 | 302 | 70763749 |
Tumour cavitation | 16.97 | 12.14 | 5 | 164388 | 22 | 70764029 |
Breast ulceration | 16.93 | 12.14 | 6 | 164387 | 52 | 70763999 |
Portal vein thrombosis | 16.90 | 12.14 | 38 | 164355 | 5324 | 70758727 |
Neutrophil count abnormal | 16.87 | 12.14 | 28 | 164365 | 3133 | 70760918 |
Product quality issue | 16.85 | 12.14 | 28 | 164365 | 30533 | 70733518 |
Glomerular vascular disorder | 16.85 | 12.14 | 8 | 164385 | 154 | 70763897 |
Pulmonary hypoplasia | 16.83 | 12.14 | 6 | 164387 | 53 | 70763998 |
Plethoric face | 16.79 | 12.14 | 5 | 164388 | 23 | 70764028 |
Ulcer | 16.76 | 12.14 | 21 | 164372 | 25733 | 70738318 |
Non-small cell lung cancer recurrent | 16.76 | 12.14 | 7 | 164386 | 98 | 70763953 |
Choriocarcinoma | 16.71 | 12.14 | 8 | 164385 | 157 | 70763894 |
Pulmonary vein stenosis | 16.71 | 12.14 | 8 | 164385 | 157 | 70763894 |
Obstruction gastric | 16.71 | 12.14 | 19 | 164374 | 1485 | 70762566 |
Schizophrenia | 16.70 | 12.14 | 9 | 164384 | 16759 | 70747292 |
Hepatic vein thrombosis | 16.61 | 12.14 | 9 | 164384 | 231 | 70763820 |
Respiratory failure | 16.53 | 12.14 | 510 | 163883 | 168225 | 70595826 |
End stage renal disease | 16.35 | 12.14 | 3 | 164390 | 11130 | 70752921 |
Double hit lymphoma | 16.35 | 12.14 | 6 | 164387 | 58 | 70763993 |
Hernia | 16.29 | 12.14 | 7 | 164386 | 14853 | 70749198 |
Obstructive airways disorder | 16.26 | 12.14 | 22 | 164371 | 26091 | 70737960 |
Angiosarcoma metastatic | 16.26 | 12.14 | 6 | 164387 | 59 | 70763992 |
Hypercholesterolaemia | 16.26 | 12.14 | 11 | 164382 | 18106 | 70745945 |
Lung squamous cell carcinoma metastatic | 16.26 | 12.14 | 6 | 164387 | 59 | 70763992 |
Vaginal cuff dehiscence | 16.25 | 12.14 | 4 | 164389 | 7 | 70764044 |
Influenza like illness | 16.22 | 12.14 | 87 | 164306 | 65244 | 70698807 |
Discontinued product administered | 16.17 | 12.14 | 6 | 164387 | 60 | 70763991 |
Protein urine | 16.13 | 12.14 | 18 | 164375 | 1378 | 70762673 |
Bladder cancer | 16.11 | 12.14 | 10 | 164383 | 17232 | 70746819 |
Dermatitis | 16.02 | 12.14 | 88 | 164305 | 19329 | 70744722 |
Mania | 15.99 | 12.14 | 10 | 164383 | 17164 | 70746887 |
Acute respiratory distress syndrome | 15.99 | 12.14 | 156 | 164237 | 41098 | 70722953 |
Apathy | 15.88 | 12.14 | 4 | 164389 | 11904 | 70752147 |
Lymphoma | 15.84 | 12.14 | 8 | 164385 | 15454 | 70748597 |
TP53 gene mutation | 15.83 | 12.14 | 5 | 164388 | 29 | 70764022 |
Brachydactyly | 15.83 | 12.14 | 5 | 164388 | 29 | 70764022 |
Keratitis | 15.82 | 12.14 | 30 | 164363 | 3727 | 70760324 |
Pancreatitis | 15.81 | 12.14 | 83 | 164310 | 62585 | 70701466 |
Cognitive disorder | 15.79 | 12.14 | 80 | 164313 | 60876 | 70703175 |
Arteriosclerosis coronary artery | 15.72 | 12.14 | 9 | 164384 | 16206 | 70747845 |
Renal cancer | 15.65 | 12.14 | 4 | 164389 | 11792 | 70752259 |
Onychalgia | 15.62 | 12.14 | 14 | 164379 | 822 | 70763229 |
Blood magnesium decreased | 15.59 | 12.14 | 72 | 164321 | 14769 | 70749282 |
Campylobacter test positive | 15.58 | 12.14 | 6 | 164387 | 67 | 70763984 |
Median nerve injury | 15.55 | 12.14 | 5 | 164388 | 31 | 70764020 |
Progressive multifocal leukoencephalopathy | 15.53 | 12.14 | 13 | 164380 | 19201 | 70744850 |
Arrhythmia | 15.52 | 12.14 | 72 | 164321 | 56071 | 70707980 |
Immune-mediated hypothyroidism | 15.52 | 12.14 | 10 | 164383 | 356 | 70763695 |
Prescribed underdose | 15.48 | 12.14 | 16 | 164377 | 21369 | 70742682 |
Miller Fisher syndrome | 15.44 | 12.14 | 8 | 164385 | 187 | 70763864 |
Depressed mood | 15.44 | 12.14 | 51 | 164342 | 43769 | 70720282 |
Tidal volume decreased | 15.42 | 12.14 | 6 | 164387 | 69 | 70763982 |
Laryngeal cancer stage III | 15.41 | 12.14 | 5 | 164388 | 32 | 70764019 |
Dysentery | 15.41 | 12.14 | 15 | 164378 | 979 | 70763072 |
Intestinal ischaemia | 15.34 | 12.14 | 62 | 164331 | 12002 | 70752049 |
Bone erosion | 15.32 | 12.14 | 8 | 164385 | 15165 | 70748886 |
Ecchymosis | 15.32 | 12.14 | 7 | 164386 | 14325 | 70749726 |
Coagulopathy | 15.25 | 12.14 | 34 | 164359 | 33215 | 70730836 |
Radiation pericarditis | 15.21 | 12.14 | 3 | 164390 | 0 | 70764051 |
Ankyloglossia acquired | 15.21 | 12.14 | 3 | 164390 | 0 | 70764051 |
Therapy non-responder | 15.17 | 12.14 | 110 | 164283 | 76805 | 70687246 |
Adenocarcinoma of appendix | 15.12 | 12.14 | 6 | 164387 | 73 | 70763978 |
Immune-mediated cholangitis | 15.07 | 12.14 | 7 | 164386 | 128 | 70763923 |
Clonal haematopoiesis | 15.03 | 12.14 | 5 | 164388 | 35 | 70764016 |
Blood pressure diastolic increased | 14.98 | 12.14 | 5 | 164388 | 12386 | 70751665 |
Fatigue | 14.95 | 12.14 | 2153 | 162240 | 822166 | 69941885 |
Pneumothorax spontaneous | 14.87 | 12.14 | 17 | 164376 | 1336 | 70762715 |
Metastases to ovary | 14.83 | 12.14 | 9 | 164384 | 288 | 70763763 |
Duodenal obstruction | 14.82 | 12.14 | 10 | 164383 | 385 | 70763666 |
Blood creatinine decreased | 14.79 | 12.14 | 44 | 164349 | 7305 | 70756746 |
Pneumoperitoneum | 14.76 | 12.14 | 25 | 164368 | 2844 | 70761207 |
Pollakiuria | 14.71 | 12.14 | 35 | 164358 | 33426 | 70730625 |
Fistula | 14.70 | 12.14 | 57 | 164336 | 10824 | 70753227 |
Osteolysis | 14.69 | 12.14 | 28 | 164365 | 3491 | 70760560 |
Uterine adhesions | 14.68 | 12.14 | 5 | 164388 | 38 | 70764013 |
Hypotension | 14.61 | 12.14 | 1107 | 163286 | 403274 | 70360777 |
Brachiocephalic vein thrombosis | 14.60 | 12.14 | 8 | 164385 | 210 | 70763841 |
Hypercalcaemia of malignancy | 14.53 | 12.14 | 10 | 164383 | 398 | 70763653 |
Invasive lobular breast carcinoma | 14.51 | 12.14 | 12 | 164381 | 632 | 70763419 |
Glomerular filtration rate decreased | 14.50 | 12.14 | 16 | 164377 | 20740 | 70743311 |
Metastases to abdominal wall | 14.45 | 12.14 | 7 | 164386 | 141 | 70763910 |
Diverticulitis | 14.41 | 12.14 | 49 | 164344 | 41685 | 70722366 |
Endometrial cancer metastatic | 14.35 | 12.14 | 5 | 164388 | 41 | 70764010 |
Cannabinoid hyperemesis syndrome | 14.35 | 12.14 | 5 | 164388 | 41 | 70764010 |
Thinking abnormal | 14.33 | 12.14 | 5 | 164388 | 12046 | 70752005 |
Secretion discharge | 14.33 | 12.14 | 6 | 164387 | 12927 | 70751124 |
Odynophagia | 14.32 | 12.14 | 54 | 164339 | 10121 | 70753930 |
Metastatic malignant melanoma | 14.24 | 12.14 | 26 | 164367 | 3138 | 70760913 |
Ankle fracture | 14.20 | 12.14 | 9 | 164384 | 15335 | 70748716 |
Diverticulum | 14.16 | 12.14 | 7 | 164386 | 13686 | 70750365 |
Carbohydrate antigen 15-3 | 14.11 | 12.14 | 6 | 164387 | 88 | 70763963 |
Superinfection bacterial | 14.09 | 12.14 | 16 | 164377 | 1248 | 70762803 |
Frequent bowel movements | 14.02 | 12.14 | 17 | 164376 | 21136 | 70742915 |
Intentional product use issue | 14.01 | 12.14 | 195 | 164198 | 119947 | 70644104 |
Lung infiltration | 14.00 | 12.14 | 92 | 164301 | 21532 | 70742519 |
Peritoneal disorder | 14.00 | 12.14 | 12 | 164381 | 664 | 70763387 |
Meibomian gland dysfunction | 13.98 | 12.14 | 7 | 164386 | 152 | 70763899 |
Needle issue | 13.92 | 12.14 | 4 | 164389 | 10911 | 70753140 |
Ovarian cancer stage III | 13.92 | 12.14 | 8 | 164385 | 231 | 70763820 |
Breast cellulitis | 13.90 | 12.14 | 9 | 164384 | 323 | 70763728 |
Pseudocyst | 13.90 | 12.14 | 9 | 164384 | 323 | 70763728 |
Steatorrhoea | 13.90 | 12.14 | 13 | 164380 | 807 | 70763244 |
Pulmonary hypertension | 13.88 | 12.14 | 58 | 164335 | 46478 | 70717573 |
Hypergeusia | 13.88 | 12.14 | 4 | 164389 | 16 | 70764035 |
Skin cancer | 13.87 | 12.14 | 7 | 164386 | 13529 | 70750522 |
Carcinoembryonic antigen | 13.87 | 12.14 | 6 | 164387 | 92 | 70763959 |
Coronary artery occlusion | 13.85 | 12.14 | 8 | 164385 | 14337 | 70749714 |
Post procedural fistula | 13.85 | 12.14 | 8 | 164385 | 233 | 70763818 |
Vascular pseudoaneurysm ruptured | 13.81 | 12.14 | 7 | 164386 | 156 | 70763895 |
Vision blurred | 13.80 | 12.14 | 147 | 164246 | 94837 | 70669214 |
Haemodialysis | 13.73 | 12.14 | 12 | 164381 | 17354 | 70746697 |
Lymphocele | 13.72 | 12.14 | 18 | 164375 | 1631 | 70762420 |
Subclavian artery occlusion | 13.69 | 12.14 | 7 | 164386 | 159 | 70763892 |
Metastases to vagina | 13.68 | 12.14 | 4 | 164389 | 17 | 70764034 |
Ear pain | 13.68 | 12.14 | 27 | 164366 | 27572 | 70736479 |
Electrocardiogram QRS complex prolonged | 13.65 | 12.14 | 3 | 164390 | 9803 | 70754248 |
Dandy-Walker syndrome | 13.65 | 12.14 | 5 | 164388 | 48 | 70764003 |
Pulmonary artery occlusion | 13.65 | 12.14 | 5 | 164388 | 48 | 70764003 |
Xeroderma | 13.58 | 12.14 | 8 | 164385 | 242 | 70763809 |
Renal disorder | 13.56 | 12.14 | 44 | 164349 | 37965 | 70726086 |
Rhinorrhoea | 13.54 | 12.14 | 94 | 164299 | 66277 | 70697774 |
Tumour hyperprogression | 13.54 | 12.14 | 7 | 164386 | 163 | 70763888 |
Upper-airway cough syndrome | 13.50 | 12.14 | 3 | 164390 | 9728 | 70754323 |
Vitamin D deficiency | 13.50 | 12.14 | 6 | 164387 | 12481 | 70751570 |
Bladder necrosis | 13.50 | 12.14 | 4 | 164389 | 18 | 70764033 |
Aortic dissection rupture | 13.50 | 12.14 | 4 | 164389 | 18 | 70764033 |
Porokeratosis | 13.43 | 12.14 | 8 | 164385 | 247 | 70763804 |
Mucosal infection | 13.39 | 12.14 | 10 | 164383 | 453 | 70763598 |
Increased tendency to bruise | 13.39 | 12.14 | 3 | 164390 | 9672 | 70754379 |
Laryngeal oedema | 13.35 | 12.14 | 43 | 164350 | 7452 | 70756599 |
Uveitis | 13.34 | 12.14 | 9 | 164384 | 14836 | 70749215 |
Lupus-like syndrome | 13.32 | 12.14 | 5 | 164388 | 11510 | 70752541 |
Abnormal dreams | 13.31 | 12.14 | 4 | 164389 | 10599 | 70753452 |
Systemic toxicity | 13.31 | 12.14 | 6 | 164387 | 102 | 70763949 |
Acute pulmonary oedema | 13.31 | 12.14 | 64 | 164329 | 13348 | 70750703 |
Cardiac failure | 13.30 | 12.14 | 431 | 163962 | 143110 | 70620941 |
Eye irritation | 13.23 | 12.14 | 13 | 164380 | 17775 | 70746276 |
Productive cough | 13.16 | 12.14 | 117 | 164276 | 78220 | 70685831 |
Acquired amegakaryocytic thrombocytopenia | 13.16 | 12.14 | 4 | 164389 | 20 | 70764031 |
Blood glucose abnormal | 13.15 | 12.14 | 3 | 164390 | 9554 | 70754497 |
Toxic neuropathy | 13.14 | 12.14 | 13 | 164380 | 865 | 70763186 |
Neoplasm | 13.14 | 12.14 | 44 | 164349 | 7780 | 70756271 |
Vaginal perforation | 13.14 | 12.14 | 3 | 164390 | 3 | 70764048 |
Ulcerated haemangioma | 13.14 | 12.14 | 3 | 164390 | 3 | 70764048 |
Peritoneal lesion | 13.14 | 12.14 | 3 | 164390 | 3 | 70764048 |
Breast prosthesis removal | 13.14 | 12.14 | 3 | 164390 | 3 | 70764048 |
Type 1 lepra reaction | 13.13 | 12.14 | 5 | 164388 | 54 | 70763997 |
Tumour perforation | 13.10 | 12.14 | 9 | 164384 | 357 | 70763694 |
Restless legs syndrome | 13.10 | 12.14 | 14 | 164379 | 18414 | 70745637 |
Diabetic ketoacidosis | 13.05 | 12.14 | 34 | 164359 | 31478 | 70732573 |
Tumour invasion | 13.04 | 12.14 | 9 | 164384 | 360 | 70763691 |
Ototoxicity | 13.03 | 12.14 | 24 | 164369 | 2917 | 70761134 |
Generalised tonic-clonic seizure | 13.01 | 12.14 | 51 | 164342 | 41610 | 70722441 |
Portal venous gas | 12.97 | 12.14 | 9 | 164384 | 363 | 70763688 |
Obstructive shock | 12.97 | 12.14 | 5 | 164388 | 56 | 70763995 |
Immune-mediated renal disorder | 12.85 | 12.14 | 6 | 164387 | 111 | 70763940 |
Mediastinal fibrosis | 12.84 | 12.14 | 4 | 164389 | 22 | 70764029 |
Pulpitis dental | 12.83 | 12.14 | 14 | 164379 | 1045 | 70763006 |
Cholecystitis chronic | 12.79 | 12.14 | 3 | 164390 | 9373 | 70754678 |
CSF white blood cell count decreased | 12.69 | 12.14 | 4 | 164389 | 23 | 70764028 |
Blood loss anaemia | 12.65 | 12.14 | 9 | 164384 | 14432 | 70749619 |
Metastases to adrenals | 12.64 | 12.14 | 15 | 164378 | 1227 | 70762824 |
Infusion site hypersensitivity | 12.55 | 12.14 | 4 | 164389 | 24 | 70764027 |
Haemolytic anaemia | 12.47 | 12.14 | 74 | 164319 | 16720 | 70747331 |
Thrombotic thrombocytopenic purpura | 12.45 | 12.14 | 37 | 164356 | 6140 | 70757911 |
Thrombocytosis | 12.39 | 12.14 | 43 | 164350 | 7741 | 70756310 |
Injection site induration | 12.38 | 12.14 | 3 | 164390 | 9165 | 70754886 |
Stent malfunction | 12.30 | 12.14 | 5 | 164388 | 65 | 70763986 |
Larynx irritation | 12.29 | 12.14 | 6 | 164387 | 123 | 70763928 |
Hereditary motor and sensory neuropathy | 12.29 | 12.14 | 6 | 164387 | 123 | 70763928 |
Radiation dysphagia | 12.28 | 12.14 | 3 | 164390 | 5 | 70764046 |
Organising pneumonia | 12.26 | 12.14 | 51 | 164342 | 9999 | 70754052 |
Poor venous access | 12.26 | 12.14 | 10 | 164383 | 14961 | 70749090 |
Nasal disorder | 12.19 | 12.14 | 25 | 164368 | 3289 | 70760762 |
Blood alkaline phosphatase increased | 12.17 | 12.14 | 197 | 164196 | 58324 | 70705727 |
Jugular vein thrombosis | 12.17 | 12.14 | 28 | 164365 | 3982 | 70760069 |
Metastases to uterus | 12.17 | 12.14 | 5 | 164388 | 67 | 70763984 |
Lung squamous cell carcinoma stage III | 12.15 | 12.14 | 4 | 164389 | 27 | 70764024 |
None
Source | Code | Description |
---|---|---|
ATC | L01CD01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Taxanes |
FDA PE | N0000175085 | Microtubule Inhibition |
FDA EPC | N0000175592 | Microtubule Inhibitor |
MeSH PA | D000970 | Antineoplastic Agents |
CHEBI has role | CHEBI:25212 | metabolites |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:61950 | microtubule stabilizing role |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D050257 | Tubulin Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ocular hypertension | indication | 4210003 | DOID:9282 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Secondary malignant neoplasm of pancreas | indication | 94459006 | |
Kaposi's sarcoma | indication | 109385007 | |
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Carcinoma of breast | indication | 254838004 | DOID:3459 |
Carcinoma of fallopian tube | indication | 276870001 | DOID:1963 |
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Malignant tumor of peritoneum | indication | 363492001 | |
Metastatic Breast Carcinoma | indication | ||
Malignant glaucoma | off-label use | 10100008 | |
Aphakic glaucoma | off-label use | 15374009 | |
Secondary glaucoma | off-label use | 95717004 | |
Neoplasm of esophagus | off-label use | 126817006 | DOID:5041 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Endometrial carcinoma | off-label use | 254878006 | DOID:2871 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Malignant tumor of cervix | off-label use | 363354003 | DOID:4362 |
Malignant tumor of testis | off-label use | 363449006 | DOID:2998 |
Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
Bronchospasm | contraindication | 4386001 | |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Complete atrioventricular block | contraindication | 27885002 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Depressive disorder | contraindication | 35489007 | |
Anaphylaxis | contraindication | 39579001 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Acute infectious disease | contraindication | 63171007 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Pulmonary emphysema | contraindication | 87433001 | |
Cardiogenic shock | contraindication | 89138009 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Liver function tests abnormal | contraindication | 166603001 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Pheochromocytoma | contraindication | 302835009 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Acute exacerbation of asthma | contraindication | 708038006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.47 | acidic |
pKa2 | 12.08 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7923536 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8138229 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8314156 | Dec. 9, 2023 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8314156 | Dec. 9, 2023 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF BREAST CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7820788 | Oct. 27, 2024 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 7758891 | Feb. 21, 2026 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8268348 | Feb. 21, 2026 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9101543 | Feb. 21, 2026 | TREATMENT OF PANCREATIC CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 8034375 | Aug. 13, 2026 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9393318 | March 4, 2032 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9597409 | March 4, 2032 | TREATMENT OF LUNG CANCER |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | 9511046 | Jan. 12, 2034 | TREATMENT OF PANCREATIC CANCER |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | Dec. 6, 2022 | ADDITIONAL CLINICAL TRIAL INFORMATION ADDED TO PEDIATRIC USE SUBSECTION |
100MG/VIAL | ABRAXANE | ABRAXIS BIOSCIENCE | N021660 | Jan. 7, 2005 | RX | POWDER | INTRAVENOUS | June 6, 2023 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | EC50 | 8.05 | IUPHAR | SCIENTIFIC LITERATURE | |||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | AGONIST | EC50 | 5.30 | IUPHAR | ||||
Delta-type opioid receptor | GPCR | Ki | 5.83 | DRUG MATRIX | |||||
Bile salt export pump | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Tubulin beta chain | Structural | INHIBITOR | EC50 | 8.05 | IUPHAR | ||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 4.62 | DRUG MATRIX | |||||
Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 4.95 | DRUG MATRIX | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 5.59 | CHEMBL | |||||
Substance-K receptor | GPCR | Ki | 5.69 | DRUG MATRIX | |||||
Melanocortin receptor 5 | GPCR | Ki | 4.79 | DRUG MATRIX | |||||
Tyrosine-protein kinase Mer | Kinase | IC50 | 5.31 | CHEMBL | |||||
Tubulin beta-3 chain | Structural | IC50 | 8.11 | CHEMBL | |||||
Nucleotide-binding oligomerization domain-containing protein 2 | Cytosolic other | IC50 | 5.10 | CHEMBL | |||||
Cholecystokinin receptor type A | GPCR | Ki | 5.64 | DRUG MATRIX | |||||
Botulinum neurotoxin type A | Enzyme | IC50 | 5.28 | CHEMBL |
ID | Source |
---|---|
4020736 | VUID |
N0000148314 | NUI |
D00491 | KEGG_DRUG |
4020736 | VANDF |
C0144576 | UMLSCUI |
CHEBI:45863 | CHEBI |
TA1 | PDB_CHEM_ID |
CHEMBL428647 | ChEMBL_ID |
D017239 | MESH_DESCRIPTOR_UI |
DB01229 | DRUGBANK_ID |
2770 | IUPHAR_LIGAND_ID |
7052 | INN_ID |
P88XT4IS4D | UNII |
36314 | PUBCHEM_CID |
196466 | RXNORM |
2296 | MMSL |
42243 | MMSL |
5224 | MMSL |
64289 | MMSL |
d01376 | MMSL |
004116 | NDDF |
387374002 | SNOMEDCT_US |
67735003 | SNOMEDCT_US |
D000068196 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3213 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3213 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3216 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3216 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3217 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3218 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-3218 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4764 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-4768 | INJECTION, SOLUTION, CONCENTRATE | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 16714-137 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-098 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-710 | INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION | 100 mg | INTRAVENOUS | NDA authorized generic | 32 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-504 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-505 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-506 | INJECTION | 6 mg | INTRAVENOUS | NDA | 22 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-613 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-593 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-593 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-594 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-594 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-595 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-595 | INJECTION, SOLUTION | 300 mg | INTRAVENOUS | ANDA | 24 sections |
Paclitaxel protein-bound particles for injectable suspension (albumin-bound) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6230 | INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION | 100 mg | INTRAVENOUS | NDA authorized generic | 32 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61703-342 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 16 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 62332-620 | INJECTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 62332-621 | INJECTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 62332-622 | INJECTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | Human Prescription Drug Label | 1 | 63323-763 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
Paclitaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-516 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 21 sections |
PACLITAXELPACLITAXEL | Human Prescription Drug Label | 1 | 68083-178 | INJECTION, SOLUTION | 6 mg | INTRAVENOUS | ANDA | 19 sections |