oxyphencyclimine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2026 125-53-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxyphencyclimine monohydrochloride
  • daricon
  • oxyphencyclimine hydrochloride
  • oxyphencyclimine
  • oxyphencyclimine HCl
cholinergic blocking agent used as an adjunct in the treatment of peptic ulcer
  • Molecular weight: 344.46
  • Formula: C20H28N2O3
  • CLOGP: 4.44
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 62.13
  • ALOGS: -3.78
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AA01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, esters with tertiary amino group
ATC A03CA03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Synthetic anticholinergic agents in combination with psycholeptics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Poisoning by phenobarbital contraindication 64921004
Substance abuse contraindication 66214007
Hepatic coma contraindication 72836002 DOID:12550
Sleep apnea contraindication 73430006 DOID:0050847
Disease of liver contraindication 235856003 DOID:409
Dyspnea contraindication 267036007
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4018397 VUID
N0000146724 NUI
C0304424 UMLSCUI
D01006 KEGG_DRUG
4V44H1O8XI UNII
839 INN_ID
4019872 VANDF
32698 RXNORM
27499006 SNOMEDCT_US
004705 NDDF
CHEMBL1495 ChEMBL_ID
DB00383 DRUGBANK_ID
125-52-0 SECONDARY_CAS_RN
C100201 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:7868 CHEBI
CHEMBL1200891 ChEMBL_ID
4642 PUBCHEM_CID
7256 IUPHAR_LIGAND_ID

Pharmaceutical products:

None