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amprenavir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| HIV protease inhibitors | 200 | 161814-49-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
; RN refers to (3S-(3R*(1S*,2R*)))-isomer; fosamprenavir is a prodrug
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.20 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.04 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 67.81 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 35 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.484 | Moderate | 0.72 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 4.055 | Moderate | 0.72 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 48.306 | 10^-6 cm/s | Moderate | 0.72 |
| dh-clint | Dog hepatocyte intrinsic clearance | 12.618 | uL/min/10^6 cells | Moderate | 0.72 |
| dppb | Dog plasma protein binding (% unbound) | 17.090 | % | Moderate | 0.72 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 28.520 | % | Moderate | 0.72 |
| herg | hERG pIC50 | 4.500 | pIC50 | Moderate | 0.72 |
| hh-clint | Human hepatocyte intrinsic clearance | 29.444 | uL/min/10^6 cells | Moderate | 0.72 |
| hlm-clint | Human liver microsomal intrinsic clearance | 214.783 | uL/min/mg protein | Moderate | 0.72 |
| hppb | Human plasma protein binding (% unbound) | 18.120 | % | Moderate | 0.72 |
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK | 21 | |||
| kinase-selectivity-class | AURKA,AXL,GRK2,TEK | 4 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 13.709 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 7.870 | Moderate | 0.72 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 133.045 | Moderate | 0.72 | |
| mppb | Mouse plasma protein binding (% unbound) | 13.250 | Moderate | 0.72 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 47.534 | Moderate | 0.72 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 25.090 | % | Moderate | 0.72 |
| rat-kpuu-brain | Rat brain Kpuu | 0.024 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 180.717 | uL/min/10^6 cells | Moderate | 0.72 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 73.500 | % | Moderate | 0.72 |
| rppb | Rat plasma protein binding (% unbound) | 15.580 | % | Moderate | 0.72 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 222.844 | uM | Moderate | 0.72 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 20, 2000 | EMA | ||
| April 15, 1999 | FDA | GLAXOSMITHKLINE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AE05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Protease inhibitors |
| FDA MoA | N0000000246 | HIV Protease Inhibitors |
| MeSH PA | D000084762 | Viral Protease Inhibitors |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000904 | Antibiotics, Antitubercular |
| MeSH PA | D000995 | Antitubercular Agents |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D017320 | HIV Protease Inhibitors |
| MeSH PA | D019380 | Anti-HIV Agents |
| MeSH PA | D044966 | Anti-Retroviral Agents |
| FDA EPC | N0000175889 | Protease Inhibitor |
| FDA MoA | N0000182141 | Cytochrome P450 3A4 Inhibitors |
| FDA MoA | N0000185506 | Cytochrome P450 3A4 Inducers |
| FDA MoA | N0000191264 | P-Glycoprotein Inducers |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35660 | HIV protease inhibitor |
| CHEBI has role | CHEBI:36044 | antiviral drug |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
Related Drugs by ATC class:
J05AE Protease inhibitors 10 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
| Prevention of HIV Infection after Exposure | off-label use | ||
| Acquired hemolytic anemia | contraindication | 4854004 | |
| Hypercholesterolemia | contraindication | 13644009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Hereditary factor VIII deficiency disease | contraindication | 28293008 | DOID:12134 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hereditary factor IX deficiency disease | contraindication | 41788008 | DOID:12259 |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Chronic type B viral hepatitis | contraindication | 61977001 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Lipodystrophy | contraindication | 71325002 | DOID:811 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Kidney stone | contraindication | 95570007 | |
| Chronic hepatitis C | contraindication | 128302006 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Familial hypercholesterolemia - homozygous | contraindication | 238078005 | |
| Hypertriglyceridemia | contraindication | 302870006 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Autoimmune hemolytic anemia | contraindication | 413603009 | DOID:718 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Obesity | contraindication | 414916001 | DOID:9970 |
| Ketoacidosis in diabetes mellitus | contraindication | 420422005 | DOID:1837 |
| Smokes tobacco daily | contraindication | 449868002 | |
| Vitamin K Deficiency Induced Hypoprothrombinemia | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.6 | acidic |
| pKa2 | 1.64 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thromboxane-A synthase | Enzyme | IC50 | 5.17 | DRUG MATRIX | |||||
| Cathepsin D | Enzyme | IC50 | 4.82 | CHEMBL | |||||
| Cytochrome P450 3A4 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
| Pol polyprotein | Enzyme | INHIBITOR | Ki | 10.40 | CHEMBL | CHEMBL | |||
| Gag-Pol polyprotein | Polyprotein | WOMBAT-PK | |||||||
| Protease | Enzyme | Ki | 10.44 | CHEMBL | |||||
| Protease | Enzyme | Ki | 10.52 | CHEMBL | |||||
| Protease | Enzyme | Ki | 9.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021158 | VUID |
| N0000148609 | NUI |
| D00894 | KEGG_DRUG |
| 228655 | RXNORM |
| C0754188 | UMLSCUI |
| CHEBI:40050 | CHEBI |
| 478 | PDB_CHEM_ID |
| CHEMBL116 | ChEMBL_ID |
| DB00701 | DRUGBANK_ID |
| C095108 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12681 | IUPHAR_LIGAND_ID |
| 7751 | INN_ID |
| 5S0W860XNR | UNII |
| 65016 | PUBCHEM_CID |
| 29919 | MMSL |
| 8067 | MMSL |
| d04428 | MMSL |
| 4021158 | VANDF |
| 007752 | NDDF |
| 116088006 | SNOMEDCT_US |
| 387006009 | SNOMEDCT_US |
| 5S0W860XNR | INXIGHT DRUGS |
Pharmaceutical products:
None