ampiroxicam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory, isoxicam derivatives | 199 | 99464-64-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
prodrug of piroxicam; structure given in first source
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
| FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
| CHEBI has role | CHEBI:35842 | anti-rheumatic drugs |
| CHEBI has role | CHEBI:50630 | COX-1 inhibitor |
| FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
| CHEBI has role | CHEBI:50266 | Prodrugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.27 | acidic |
| pKa2 | 4.73 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01397 | KEGG_DRUG |
| 8356 | RXNORM |
| C0246289 | UMLSCUI |
| CHEBI:31210 | CHEBI |
| CHEBI:8249 | CHEBI |
| CHEMBL1566249 | ChEMBL_ID |
| DB16877 | DRUGBANK_ID |
| C065946 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6047 | INN_ID |
| 0PV32JZB1J | UNII |
| 2176 | PUBCHEM_CID |
| 1529 | MMSL |
| 5308 | MMSL |
| d00343 | MMSL |
| 27754002 | SNOMEDCT_US |
| 387153005 | SNOMEDCT_US |
| C0031990 | UMLSCUI |
| DB00554 | DRUGBANK_ID |
| 4018626 | VANDF |
| 3713 | INN_ID |
| D010894 | MESH_DESCRIPTOR_UI |
| 54676228 | PUBCHEM_CID |
| 002389 | NDDF |
Pharmaceutical products:
None