nomifensine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
norepinephrine, serotonin, dopamine reuptake inhibitors 1958 24526-64-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • merital
  • nomifensine maleate
  • nomifensine
  • (+/-)-Nomifensin
  • (+/-)-Nomifensine
  • linamiphen
  • nomifensin
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
  • Molecular weight: 238.33
  • Formula: C16H18N2
  • CLOGP: 2.37
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.26
  • ALOGS: -2.87
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

Approvals:

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

None

nomifensine