nifuroxazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
5-nitrofuran derivatives	1928	965-52-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

nifuroxazide
dicoferin
nifuroxazid
pentofuryl

Molecular weight: 275.22
Formula: C12H9N3O5
CLOGP: 1.90
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 120.65
ALOGS: -3.42
ROTB: 4

Drug dosage:

Dose	Unit	Route
0.60	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trimethylaminuria	147.94	87.52	17	373	156	63488476
Pseudomembranous colitis	105.70	87.52	18	372	3094	63485538
Megacolon	99.79	87.52	16	374	1899	63486733

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trimethylaminuria	156.32	63.37	18	447	178	79743745
Pseudomembranous colitis	103.16	63.37	19	446	5355	79738568
Megacolon	97.68	63.37	17	448	3478	79740445
Dysbiosis	77.34	63.37	12	453	1207	79742716
Intestinal perforation	75.64	63.37	18	447	17408	79726515
Peritonitis	71.91	63.37	19	446	28017	79715906
Clostridium difficile infection	68.40	63.37	20	445	42665	79701258

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07AX03	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Other intestinal antiinfectives
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.75	acidic
pKa2	10.28	acidic
pKa3	2.04	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Signal transducer and activator of transcription 3	Transcription factor	P40763	STAT3_HUMAN		EC50	5.52		CHEMBL

External reference:

ID	Source
D07111	KEGG_DRUG
C0068742	UMLSCUI
CHEBI:135136	CHEBI
CHEMBL244888	ChEMBL_ID
DB13855	DRUGBANK_ID
C013150	MESH_SUPPLEMENTAL_RECORD_UI
5337997	PUBCHEM_CID
12358	IUPHAR_LIGAND_ID
1578	INN_ID
PM5LI0P38J	UNII
31782	RXNORM
005828	NDDF
703471002	SNOMEDCT_US
703472009	SNOMEDCT_US

Pharmaceutical products:

None