nifedipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, nifedipine derivatives | 1922 | 21829-25-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
| 30 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.01 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.71 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.79 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 7.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 31, 1981 | FDA | PFIZER |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Premature delivery | 674.67 | 10.09 | 404 | 62990 | 29877 | 63395751 |
| Exposure during pregnancy | 318.68 | 10.09 | 563 | 62831 | 154984 | 63270644 |
| Premature baby | 299.83 | 10.09 | 211 | 63183 | 20524 | 63405104 |
| Low birth weight baby | 206.62 | 10.09 | 113 | 63281 | 7016 | 63418612 |
| Pre-eclampsia | 178.11 | 10.09 | 112 | 63282 | 9021 | 63416607 |
| Pemphigus | 147.56 | 10.09 | 9 | 63385 | 183717 | 63241911 |
| Foetal exposure during pregnancy | 143.09 | 10.09 | 168 | 63226 | 31794 | 63393834 |
| Alopecia | 136.83 | 10.09 | 84 | 63310 | 337452 | 63088176 |
| Glossodynia | 124.22 | 10.09 | 16 | 63378 | 178860 | 63246768 |
| Maternal exposure during pregnancy | 116.90 | 10.09 | 482 | 62912 | 219580 | 63206048 |
| Blood pressure inadequately controlled | 114.89 | 10.09 | 68 | 63326 | 4910 | 63420718 |
| Hypotension | 106.86 | 10.09 | 546 | 62848 | 272058 | 63153570 |
| Arthropathy | 94.28 | 10.09 | 59 | 63335 | 234733 | 63190895 |
| Renal impairment | 92.64 | 10.09 | 244 | 63150 | 88111 | 63337517 |
| Pericarditis | 90.78 | 10.09 | 12 | 63382 | 131567 | 63294061 |
| Systemic lupus erythematosus | 90.29 | 10.09 | 48 | 63346 | 208870 | 63216758 |
| Neovascularisation | 89.34 | 10.09 | 36 | 63358 | 1109 | 63424519 |
| Premature labour | 86.75 | 10.09 | 83 | 63311 | 12421 | 63413207 |
| Wound | 85.84 | 10.09 | 28 | 63366 | 163235 | 63262393 |
| Therapeutic product effect decreased | 84.04 | 10.09 | 44 | 63350 | 193143 | 63232485 |
| Caesarean section | 82.06 | 10.09 | 93 | 63301 | 16939 | 63408689 |
| Oedema peripheral | 79.43 | 10.09 | 387 | 63007 | 189124 | 63236504 |
| Discomfort | 79.12 | 10.09 | 34 | 63360 | 167340 | 63258288 |
| Blood pressure increased | 73.77 | 10.09 | 339 | 63055 | 161723 | 63263905 |
| Infusion related reaction | 72.47 | 10.09 | 83 | 63311 | 245438 | 63180190 |
| Foetal growth restriction | 72.00 | 10.09 | 60 | 63334 | 7493 | 63418135 |
| Helicobacter infection | 70.28 | 10.09 | 6 | 63388 | 92779 | 63332849 |
| Rheumatoid factor positive | 68.14 | 10.09 | 4 | 63390 | 84402 | 63341226 |
| Cardiac failure congestive | 67.94 | 10.09 | 225 | 63169 | 92208 | 63333420 |
| Blood aldosterone increased | 67.48 | 10.09 | 19 | 63375 | 184 | 63425444 |
| Proteinuria | 65.51 | 10.09 | 88 | 63306 | 19057 | 63406571 |
| Contraindicated product administered | 61.63 | 10.09 | 76 | 63318 | 217572 | 63208056 |
| Hypersensitivity | 60.46 | 10.09 | 126 | 63268 | 292559 | 63133069 |
| Joint swelling | 59.67 | 10.09 | 151 | 63243 | 327515 | 63098113 |
| Cerebral infarction | 58.79 | 10.09 | 94 | 63300 | 23799 | 63401829 |
| Aplastic anaemia | 54.38 | 10.09 | 57 | 63337 | 9512 | 63416116 |
| Scleroderma | 53.33 | 10.09 | 44 | 63350 | 5418 | 63420210 |
| Pulmonary oedema | 51.95 | 10.09 | 146 | 63248 | 54727 | 63370901 |
| Abdominal discomfort | 51.62 | 10.09 | 157 | 63237 | 320728 | 63104900 |
| Anuria | 51.29 | 10.09 | 63 | 63331 | 12488 | 63413140 |
| Primary hyperaldosteronism | 51.08 | 10.09 | 12 | 63382 | 51 | 63425577 |
| Transfusion | 50.63 | 10.09 | 69 | 63325 | 15148 | 63410480 |
| Synovitis | 50.09 | 10.09 | 68 | 63326 | 186850 | 63238778 |
| Dyspnoea exertional | 49.03 | 10.09 | 152 | 63242 | 60150 | 63365478 |
| Rash | 48.75 | 10.09 | 344 | 63050 | 560527 | 62865101 |
| Cardiac failure | 48.61 | 10.09 | 197 | 63197 | 88945 | 63336683 |
| Blood pressure diastolic abnormal | 48.47 | 10.09 | 66 | 63328 | 14476 | 63411152 |
| Paradoxical drug reaction | 48.14 | 10.09 | 37 | 63357 | 4115 | 63421513 |
| Oligohydramnios | 47.50 | 10.09 | 44 | 63350 | 6322 | 63419306 |
| Polyhydramnios | 47.18 | 10.09 | 29 | 63365 | 2242 | 63423386 |
| Shock | 46.72 | 10.09 | 84 | 63310 | 23379 | 63402249 |
| Bradycardia | 46.63 | 10.09 | 170 | 63224 | 73057 | 63352571 |
| Blood pressure systolic abnormal | 46.52 | 10.09 | 62 | 63332 | 13324 | 63412304 |
| Wrist deformity | 46.30 | 10.09 | 28 | 63366 | 2102 | 63423526 |
| Treatment failure | 46.06 | 10.09 | 80 | 63314 | 198963 | 63226665 |
| Drug intolerance | 44.14 | 10.09 | 159 | 63235 | 308502 | 63117126 |
| Acute pulmonary oedema | 43.53 | 10.09 | 47 | 63347 | 8111 | 63417517 |
| Lower respiratory tract infection | 43.20 | 10.09 | 41 | 63353 | 132266 | 63293362 |
| Blood creatinine increased | 43.12 | 10.09 | 188 | 63206 | 87656 | 63337972 |
| Heart rate decreased | 42.91 | 10.09 | 121 | 63273 | 45439 | 63380189 |
| Intestinal angioedema | 42.33 | 10.09 | 18 | 63376 | 637 | 63424991 |
| Drug ineffective | 42.17 | 10.09 | 763 | 62631 | 1044002 | 62381626 |
| Pain | 41.18 | 10.09 | 508 | 62886 | 740120 | 62685508 |
| Hepatic enzyme increased | 41.00 | 10.09 | 88 | 63306 | 202240 | 63223388 |
| Impaired healing | 39.44 | 10.09 | 27 | 63367 | 102515 | 63323113 |
| Sinusitis | 38.53 | 10.09 | 108 | 63286 | 226545 | 63199083 |
| Rectal prolapse | 37.86 | 10.09 | 24 | 63370 | 1959 | 63423669 |
| Uraemic encephalopathy | 37.33 | 10.09 | 13 | 63381 | 264 | 63425364 |
| Eclampsia | 36.82 | 10.09 | 14 | 63380 | 368 | 63425260 |
| Product use issue | 36.07 | 10.09 | 107 | 63287 | 220413 | 63205215 |
| Hypertensive crisis | 36.05 | 10.09 | 59 | 63335 | 15227 | 63410401 |
| Bladder prolapse | 36.03 | 10.09 | 24 | 63370 | 2132 | 63423496 |
| Hypergammaglobulinaemia | 35.95 | 10.09 | 15 | 63379 | 506 | 63425122 |
| Dialysis | 35.78 | 10.09 | 48 | 63346 | 10379 | 63415249 |
| Superimposed pre-eclampsia | 35.46 | 10.09 | 6 | 63388 | 0 | 63425628 |
| Drug dispensed to wrong patient | 35.42 | 10.09 | 13 | 63381 | 309 | 63425319 |
| Drug interaction | 33.96 | 10.09 | 364 | 63030 | 228767 | 63196861 |
| Cerebrovascular accident | 33.94 | 10.09 | 204 | 63190 | 107820 | 63317808 |
| Product complaint | 33.74 | 10.09 | 52 | 63342 | 12757 | 63412871 |
| Hypocalvaria | 33.33 | 10.09 | 8 | 63386 | 38 | 63425590 |
| Swelling | 32.99 | 10.09 | 152 | 63242 | 275226 | 63150402 |
| Dyspnoea | 32.86 | 10.09 | 878 | 62516 | 660435 | 62765193 |
| Fatigue | 32.84 | 10.09 | 658 | 62736 | 887370 | 62538258 |
| Knee arthroplasty | 32.83 | 10.09 | 7 | 63387 | 54199 | 63371429 |
| Psoriatic arthropathy | 32.74 | 10.09 | 26 | 63368 | 91494 | 63334134 |
| Blood pressure systolic increased | 32.71 | 10.09 | 113 | 63281 | 47284 | 63378344 |
| Phaeochromocytoma | 32.67 | 10.09 | 14 | 63380 | 505 | 63425123 |
| Irritable bowel syndrome | 32.64 | 10.09 | 21 | 63373 | 82391 | 63343237 |
| Fibromyalgia | 32.53 | 10.09 | 20 | 63374 | 80400 | 63345228 |
| Neonatal respiratory distress syndrome | 32.43 | 10.09 | 25 | 63369 | 2793 | 63422835 |
| Hyperkalaemia | 32.14 | 10.09 | 123 | 63271 | 54080 | 63371548 |
| Infection | 32.12 | 10.09 | 119 | 63275 | 229054 | 63196574 |
| Tubulointerstitial nephritis | 31.92 | 10.09 | 65 | 63329 | 19838 | 63405790 |
| Peripartum cardiomyopathy | 31.84 | 10.09 | 10 | 63384 | 145 | 63425483 |
| Premature separation of placenta | 31.78 | 10.09 | 21 | 63373 | 1840 | 63423788 |
| Blood pressure decreased | 31.78 | 10.09 | 139 | 63255 | 64883 | 63360745 |
| Renal artery stenosis | 31.30 | 10.09 | 21 | 63373 | 1888 | 63423740 |
| Respiratory tract inflammation | 30.63 | 10.09 | 14 | 63380 | 590 | 63425038 |
| Renin decreased | 30.53 | 10.09 | 9 | 63385 | 104 | 63425524 |
| Hypervolaemia | 30.30 | 10.09 | 79 | 63315 | 28334 | 63397294 |
| Blister | 30.17 | 10.09 | 52 | 63342 | 129762 | 63295866 |
| Blood pressure fluctuation | 29.88 | 10.09 | 108 | 63286 | 46209 | 63379419 |
| Nodular regenerative hyperplasia | 29.73 | 10.09 | 13 | 63381 | 493 | 63425135 |
| Angina unstable | 29.61 | 10.09 | 36 | 63358 | 7059 | 63418569 |
| Renal failure | 29.53 | 10.09 | 210 | 63184 | 117442 | 63308186 |
| Pain in jaw | 29.41 | 10.09 | 103 | 63291 | 43393 | 63382235 |
| Hypertension | 29.39 | 10.09 | 416 | 62978 | 278887 | 63146741 |
| Adverse drug reaction | 29.33 | 10.09 | 22 | 63372 | 79692 | 63345936 |
| Injection site erythema | 29.28 | 10.09 | 24 | 63370 | 83150 | 63342478 |
| CD30 expression | 28.54 | 10.09 | 7 | 63387 | 37 | 63425591 |
| Foetal death | 28.12 | 10.09 | 44 | 63350 | 10936 | 63414692 |
| Foetal distress syndrome | 27.58 | 10.09 | 17 | 63377 | 1321 | 63424307 |
| Cognitive disorder | 26.90 | 10.09 | 11 | 63383 | 55804 | 63369824 |
| Product residue present | 26.82 | 10.09 | 26 | 63368 | 3953 | 63421675 |
| Pulmonary hypertension | 26.04 | 10.09 | 89 | 63305 | 37034 | 63388594 |
| Peripheral vascular disorder | 25.81 | 10.09 | 31 | 63363 | 6004 | 63419624 |
| Thermal burn | 25.76 | 10.09 | 31 | 63363 | 6015 | 63419613 |
| Aortic dissection | 25.65 | 10.09 | 19 | 63375 | 1999 | 63423629 |
| Swollen joint count increased | 25.55 | 10.09 | 3 | 63391 | 36051 | 63389577 |
| Drug abuse | 25.44 | 10.09 | 21 | 63373 | 72497 | 63353131 |
| Patent ductus arteriosus | 25.38 | 10.09 | 26 | 63368 | 4224 | 63421404 |
| Electrocardiogram PR prolongation | 25.29 | 10.09 | 13 | 63381 | 711 | 63424917 |
| Maternal condition affecting foetus | 25.13 | 10.09 | 9 | 63385 | 199 | 63425429 |
| Blood pressure diastolic decreased | 25.10 | 10.09 | 64 | 63330 | 22642 | 63402986 |
| Drug ineffective for unapproved indication | 25.08 | 10.09 | 83 | 63311 | 33980 | 63391648 |
| Blood urea increased | 24.77 | 10.09 | 70 | 63324 | 26309 | 63399319 |
| Liver injury | 24.54 | 10.09 | 15 | 63379 | 60505 | 63365123 |
| Injection site reaction | 24.45 | 10.09 | 14 | 63380 | 58510 | 63367118 |
| Acute myocardial infarction | 24.30 | 10.09 | 79 | 63315 | 32045 | 63393583 |
| Diabetic nephropathy | 23.85 | 10.09 | 16 | 63378 | 1438 | 63424190 |
| Neutropenia | 23.78 | 10.09 | 92 | 63302 | 174913 | 63250715 |
| Hip arthroplasty | 23.60 | 10.09 | 9 | 63385 | 47637 | 63377991 |
| HELLP syndrome | 23.41 | 10.09 | 14 | 63380 | 1030 | 63424598 |
| Metabolic acidosis | 23.29 | 10.09 | 98 | 63296 | 44971 | 63380657 |
| Infrequent bowel movements | 22.99 | 10.09 | 15 | 63379 | 1287 | 63424341 |
| Psoriasis | 22.91 | 10.09 | 32 | 63362 | 86925 | 63338703 |
| Foetal exposure timing unspecified | 22.84 | 10.09 | 9 | 63385 | 261 | 63425367 |
| Intentional product use issue | 22.42 | 10.09 | 60 | 63334 | 127832 | 63297796 |
| Finger amputation | 22.35 | 10.09 | 11 | 63383 | 548 | 63425080 |
| Preterm premature rupture of membranes | 21.91 | 10.09 | 15 | 63379 | 1394 | 63424234 |
| Type 2 diabetes mellitus | 21.78 | 10.09 | 19 | 63375 | 63849 | 63361779 |
| Fluid retention | 21.55 | 10.09 | 117 | 63277 | 59569 | 63366059 |
| Pulmonary arterial hypertension | 21.29 | 10.09 | 60 | 63334 | 22517 | 63403111 |
| Endometritis | 21.15 | 10.09 | 13 | 63381 | 1005 | 63424623 |
| Acute kidney injury | 21.13 | 10.09 | 375 | 63019 | 263040 | 63162588 |
| BRASH syndrome | 21.08 | 10.09 | 10 | 63384 | 459 | 63425169 |
| Palpitations | 21.01 | 10.09 | 188 | 63206 | 112582 | 63313046 |
| Angina pectoris | 21.00 | 10.09 | 72 | 63322 | 30006 | 63395622 |
| Hepatic function abnormal | 20.97 | 10.09 | 83 | 63311 | 37059 | 63388569 |
| Myocardial infarction | 20.96 | 10.09 | 171 | 63223 | 99722 | 63325906 |
| Hepatic rupture | 20.96 | 10.09 | 6 | 63388 | 62 | 63425566 |
| Therapeutic product effect incomplete | 20.93 | 10.09 | 60 | 63334 | 124996 | 63300632 |
| Respiratory distress | 20.91 | 10.09 | 78 | 63316 | 33873 | 63391755 |
| Rheumatoid arthritis | 20.85 | 10.09 | 158 | 63236 | 253661 | 63171967 |
| Urticaria | 20.75 | 10.09 | 90 | 63304 | 165712 | 63259916 |
| Left ventricular hypertrophy | 20.63 | 10.09 | 26 | 63368 | 5289 | 63420339 |
| Urine output decreased | 20.49 | 10.09 | 39 | 63355 | 11331 | 63414297 |
| Nephrogenic systemic fibrosis | 20.47 | 10.09 | 24 | 63370 | 4532 | 63421096 |
| Injection site inflammation | 20.26 | 10.09 | 22 | 63372 | 3821 | 63421807 |
| Renal hypoplasia | 20.14 | 10.09 | 5 | 63389 | 28 | 63425600 |
| Stomatitis | 20.10 | 10.09 | 71 | 63323 | 138654 | 63286974 |
| Stillbirth | 20.06 | 10.09 | 29 | 63365 | 6721 | 63418907 |
| Chronic kidney disease | 19.91 | 10.09 | 94 | 63300 | 45304 | 63380324 |
| Vitamin D decreased | 19.54 | 10.09 | 36 | 63358 | 10206 | 63415422 |
| Porphyria acute | 19.42 | 10.09 | 13 | 63381 | 1164 | 63424464 |
| Haemoglobin decreased | 19.20 | 10.09 | 226 | 63168 | 145259 | 63280369 |
| Oedema | 18.83 | 10.09 | 164 | 63230 | 97458 | 63328170 |
| Bradycardia foetal | 18.70 | 10.09 | 9 | 63385 | 427 | 63425201 |
| Gestational hypertension | 18.60 | 10.09 | 17 | 63377 | 2400 | 63423228 |
| Extrapyramidal disorder | 18.54 | 10.09 | 41 | 63353 | 13243 | 63412385 |
| Barotrauma | 18.52 | 10.09 | 7 | 63387 | 181 | 63425447 |
| Drug titration error | 18.36 | 10.09 | 11 | 63383 | 812 | 63424816 |
| Frostbite | 18.22 | 10.09 | 6 | 63388 | 102 | 63425526 |
| Hypertensive emergency | 18.04 | 10.09 | 15 | 63379 | 1867 | 63423761 |
| Atrial septal defect | 18.04 | 10.09 | 28 | 63366 | 6910 | 63418718 |
| Vascular resistance systemic increased | 17.73 | 10.09 | 3 | 63391 | 0 | 63425628 |
| Oxygen saturation decreased | 17.71 | 10.09 | 150 | 63244 | 88435 | 63337193 |
| Cardiac arrest | 17.61 | 10.09 | 155 | 63239 | 92390 | 63333238 |
| Myocardial depression | 17.46 | 10.09 | 9 | 63385 | 495 | 63425133 |
| Hypovolaemic shock | 17.38 | 10.09 | 26 | 63368 | 6215 | 63419413 |
| Atrioventricular block | 17.34 | 10.09 | 29 | 63365 | 7618 | 63418010 |
| Hypertension neonatal | 17.22 | 10.09 | 4 | 63390 | 16 | 63425612 |
| Multiple sclerosis relapse | 17.05 | 10.09 | 14 | 63380 | 48464 | 63377164 |
| Platelet count decreased | 16.96 | 10.09 | 184 | 63210 | 115938 | 63309690 |
| Arrhythmia | 16.74 | 10.09 | 79 | 63315 | 38061 | 63387567 |
| Transferrin decreased | 16.70 | 10.09 | 7 | 63387 | 239 | 63425389 |
| Spinal cord infarction | 16.22 | 10.09 | 7 | 63387 | 257 | 63425371 |
| Intentional self-injury | 16.22 | 10.09 | 3 | 63391 | 25684 | 63399944 |
| Contusion | 16.11 | 10.09 | 86 | 63308 | 149958 | 63275670 |
| Use of accessory respiratory muscles | 16.04 | 10.09 | 7 | 63387 | 264 | 63425364 |
| Gastrointestinal disorder | 15.95 | 10.09 | 72 | 63322 | 131167 | 63294461 |
| Hyperuricaemia | 15.86 | 10.09 | 23 | 63371 | 5347 | 63420281 |
| Foetal exposure during delivery | 15.77 | 10.09 | 6 | 63388 | 158 | 63425470 |
| Product substitution error | 15.74 | 10.09 | 4 | 63390 | 25 | 63425603 |
| Atrioventricular block first degree | 15.72 | 10.09 | 27 | 63367 | 7246 | 63418382 |
| Coronary artery disease | 15.65 | 10.09 | 69 | 63325 | 32308 | 63393320 |
| Pseudolymphoma | 15.59 | 10.09 | 9 | 63385 | 620 | 63425008 |
| Hypertensive encephalopathy | 15.47 | 10.09 | 9 | 63385 | 629 | 63424999 |
| Laboratory test interference | 15.37 | 10.09 | 9 | 63385 | 637 | 63424991 |
| Oral herpes | 15.31 | 10.09 | 59 | 63335 | 26015 | 63399613 |
| Nephrotic syndrome | 15.20 | 10.09 | 23 | 63371 | 5553 | 63420075 |
| Respiratory failure | 15.15 | 10.09 | 162 | 63232 | 101696 | 63323932 |
| Macular degeneration | 15.06 | 10.09 | 3 | 63391 | 24373 | 63401255 |
| Heliotrope rash | 15.01 | 10.09 | 6 | 63388 | 181 | 63425447 |
| Exposure via breast milk | 14.93 | 10.09 | 14 | 63380 | 2043 | 63423585 |
| Ileal ulcer | 14.88 | 10.09 | 8 | 63386 | 480 | 63425148 |
| Cardiomegaly | 14.87 | 10.09 | 45 | 63349 | 17569 | 63408059 |
| Renin increased | 14.79 | 10.09 | 6 | 63388 | 188 | 63425440 |
| Altered state of consciousness | 14.74 | 10.09 | 57 | 63337 | 25173 | 63400455 |
| Injection site pruritus | 14.70 | 10.09 | 14 | 63380 | 45102 | 63380526 |
| Renal atrophy | 14.60 | 10.09 | 12 | 63382 | 1470 | 63424158 |
| Foetal heart rate deceleration abnormality | 14.56 | 10.09 | 8 | 63386 | 501 | 63425127 |
| Scleroderma renal crisis | 14.52 | 10.09 | 7 | 63387 | 333 | 63425295 |
| Skin induration | 14.51 | 10.09 | 17 | 63377 | 3206 | 63422422 |
| Malignant hypertension | 14.48 | 10.09 | 11 | 63383 | 1202 | 63424426 |
| Wheezing | 14.47 | 10.09 | 48 | 63346 | 95547 | 63330081 |
| Foetal hypokinesia | 14.40 | 10.09 | 8 | 63386 | 512 | 63425116 |
| Umbilical cord vascular disorder | 14.34 | 10.09 | 5 | 63389 | 102 | 63425526 |
| Premature rupture of membranes | 14.19 | 10.09 | 21 | 63373 | 4972 | 63420656 |
| Aortic valve incompetence | 13.97 | 10.09 | 23 | 63371 | 5965 | 63419663 |
| Therapy partial responder | 13.88 | 10.09 | 32 | 63362 | 10626 | 63415002 |
| Accidental exposure to product | 13.87 | 10.09 | 5 | 63389 | 27400 | 63398228 |
| Poikiloderma | 13.83 | 10.09 | 6 | 63388 | 223 | 63425405 |
| Skin hypertrophy | 13.82 | 10.09 | 17 | 63377 | 3374 | 63422254 |
| COVID-19 | 13.78 | 10.09 | 62 | 63332 | 113041 | 63312587 |
| Hypoaesthesia teeth | 13.75 | 10.09 | 4 | 63390 | 44 | 63425584 |
| Human chorionic gonadotropin positive | 13.66 | 10.09 | 4 | 63390 | 45 | 63425583 |
| Ventricular hypertrophy | 13.64 | 10.09 | 17 | 63377 | 3419 | 63422209 |
| General physical health deterioration | 13.57 | 10.09 | 132 | 63262 | 201270 | 63224358 |
| Blood lactate dehydrogenase increased | 13.32 | 10.09 | 52 | 63342 | 23064 | 63402564 |
| Haemoperitoneum | 13.26 | 10.09 | 15 | 63379 | 2726 | 63422902 |
| Adverse event | 13.16 | 10.09 | 30 | 63364 | 67529 | 63358099 |
| Cervical incompetence | 13.13 | 10.09 | 8 | 63386 | 609 | 63425019 |
| Prescribed overdose | 13.12 | 10.09 | 9 | 63385 | 34144 | 63391484 |
| Hypoproteinaemia | 13.09 | 10.09 | 13 | 63381 | 2036 | 63423592 |
| Joint contracture | 13.02 | 10.09 | 12 | 63382 | 1712 | 63423916 |
| Neonatal hyponatraemia | 13.00 | 10.09 | 4 | 63390 | 54 | 63425574 |
| Renal impairment neonatal | 13.00 | 10.09 | 4 | 63390 | 54 | 63425574 |
| Cortisol increased | 12.99 | 10.09 | 7 | 63387 | 422 | 63425206 |
| Dermatophytosis of nail | 12.74 | 10.09 | 4 | 63390 | 58 | 63425570 |
| Wrong technique in product usage process | 12.70 | 10.09 | 27 | 63367 | 62313 | 63363315 |
| Live birth | 12.68 | 10.09 | 55 | 63339 | 25575 | 63400053 |
| Lacunar infarction | 12.66 | 10.09 | 16 | 63378 | 3264 | 63422364 |
| Small for dates baby | 12.46 | 10.09 | 17 | 63377 | 3734 | 63421894 |
| Musculoskeletal stiffness | 12.43 | 10.09 | 121 | 63273 | 184497 | 63241131 |
| Jaundice neonatal | 12.41 | 10.09 | 9 | 63385 | 916 | 63424712 |
| Ill-defined disorder | 12.41 | 10.09 | 41 | 63353 | 81714 | 63343914 |
| Feeling cold | 12.39 | 10.09 | 52 | 63342 | 23836 | 63401792 |
| Neuromuscular blockade | 12.32 | 10.09 | 6 | 63388 | 292 | 63425336 |
| Sleep disorder | 12.32 | 10.09 | 41 | 63353 | 81525 | 63344103 |
| Rheumatic fever | 12.24 | 10.09 | 15 | 63379 | 43096 | 63382532 |
| Weight increased | 12.20 | 10.09 | 185 | 63209 | 260607 | 63165021 |
| Skin tightness | 12.04 | 10.09 | 18 | 63376 | 4298 | 63421330 |
| Nasopharyngitis | 12.02 | 10.09 | 180 | 63214 | 254077 | 63171551 |
| Hypoglycaemia neonatal | 11.99 | 10.09 | 9 | 63385 | 966 | 63424662 |
| Amniotic cavity infection | 11.97 | 10.09 | 10 | 63384 | 1253 | 63424375 |
| Systemic scleroderma | 11.94 | 10.09 | 9 | 63385 | 972 | 63424656 |
| Hypoxia | 11.82 | 10.09 | 101 | 63293 | 59691 | 63365937 |
| Haemodialysis | 11.80 | 10.09 | 27 | 63367 | 8920 | 63416708 |
| Antibody test positive | 11.73 | 10.09 | 14 | 63380 | 2693 | 63422935 |
| Transient ischaemic attack | 11.66 | 10.09 | 71 | 63323 | 37682 | 63387946 |
| Ductus arteriosus premature closure | 11.64 | 10.09 | 6 | 63388 | 330 | 63425298 |
| Iron binding capacity total decreased | 11.61 | 10.09 | 6 | 63388 | 332 | 63425296 |
| Anaemia | 11.60 | 10.09 | 379 | 63015 | 293051 | 63132577 |
| Pancreatitis haemorrhagic | 11.57 | 10.09 | 7 | 63387 | 526 | 63425102 |
| Carotid artery disease | 11.54 | 10.09 | 11 | 63383 | 1638 | 63423990 |
| Microvillous inclusion disease | 11.51 | 10.09 | 3 | 63391 | 21 | 63425607 |
| Blood corticotrophin decreased | 11.49 | 10.09 | 6 | 63388 | 339 | 63425289 |
| Mental status changes | 11.31 | 10.09 | 73 | 63321 | 39526 | 63386102 |
| Sinus bradycardia | 11.20 | 10.09 | 36 | 63358 | 14515 | 63411113 |
| Stevens-Johnson syndrome | 11.18 | 10.09 | 52 | 63342 | 24898 | 63400730 |
| Device expulsion | 11.18 | 10.09 | 11 | 63383 | 34911 | 63390717 |
| Platelet transfusion | 11.18 | 10.09 | 8 | 63386 | 798 | 63424830 |
| Foot deformity | 11.16 | 10.09 | 7 | 63387 | 27846 | 63397782 |
| Febrile neutropenia | 11.06 | 10.09 | 71 | 63323 | 118378 | 63307250 |
| Cough | 11.03 | 10.09 | 376 | 63018 | 292367 | 63133261 |
| Muscle spasticity | 10.99 | 10.09 | 4 | 63390 | 21790 | 63403838 |
| Glomerulonephritis membranoproliferative | 10.93 | 10.09 | 5 | 63389 | 211 | 63425417 |
| End stage renal disease | 10.90 | 10.09 | 22 | 63372 | 6671 | 63418957 |
| Haemodialysis complication | 10.89 | 10.09 | 5 | 63389 | 213 | 63425415 |
| Pulmonary embolism | 10.86 | 10.09 | 70 | 63324 | 116614 | 63309014 |
| Arthralgia | 10.82 | 10.09 | 462 | 62932 | 569248 | 62856380 |
| Brain natriuretic peptide increased | 10.81 | 10.09 | 19 | 63375 | 5194 | 63420434 |
| Threatened labour | 10.76 | 10.09 | 8 | 63386 | 846 | 63424782 |
| Pneumonia | 10.71 | 10.09 | 558 | 62836 | 456209 | 62969419 |
| Hypoperfusion | 10.67 | 10.09 | 10 | 63384 | 1457 | 63424171 |
| Hyperplasia adrenal | 10.66 | 10.09 | 3 | 63391 | 29 | 63425599 |
| Congenital hypothyroidism | 10.59 | 10.09 | 5 | 63389 | 227 | 63425401 |
| Arteriovenous fistula operation | 10.49 | 10.09 | 5 | 63389 | 232 | 63425396 |
| Large intestine benign neoplasm | 10.42 | 10.09 | 4 | 63390 | 108 | 63425520 |
| Pancreatic neuroendocrine tumour metastatic | 10.39 | 10.09 | 3 | 63391 | 32 | 63425596 |
| Decreased appetite | 10.37 | 10.09 | 326 | 63068 | 250726 | 63174902 |
| Mallory-Weiss syndrome | 10.37 | 10.09 | 10 | 63384 | 1511 | 63424117 |
| Abdominal distension | 10.32 | 10.09 | 132 | 63262 | 86483 | 63339145 |
| Histiocytic necrotising lymphadenitis | 10.31 | 10.09 | 3 | 63391 | 33 | 63425595 |
| Intestinal pseudo-obstruction | 10.30 | 10.09 | 8 | 63386 | 904 | 63424724 |
| Electrocardiogram abnormal | 10.28 | 10.09 | 26 | 63368 | 9153 | 63416475 |
| Hospitalisation | 10.28 | 10.09 | 130 | 63264 | 84951 | 63340677 |
| Hyporeflexia | 10.26 | 10.09 | 11 | 63383 | 1884 | 63423744 |
| Gastrooesophageal reflux disease | 10.25 | 10.09 | 143 | 63251 | 95496 | 63330132 |
| Blood chloride increased | 10.21 | 10.09 | 13 | 63381 | 2671 | 63422957 |
| Renal tubular dysfunction | 10.19 | 10.09 | 6 | 63388 | 429 | 63425199 |
| Renal disorder | 10.17 | 10.09 | 62 | 63332 | 32912 | 63392716 |
| Pyuria | 10.16 | 10.09 | 11 | 63383 | 1903 | 63423725 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Premature baby | 234.26 | 10.73 | 194 | 42916 | 19439 | 34894382 |
| Low birth weight baby | 154.42 | 10.73 | 105 | 43005 | 7800 | 34906021 |
| Foetal exposure during pregnancy | 126.91 | 10.73 | 193 | 42917 | 37908 | 34875913 |
| Photodermatosis | 99.01 | 10.73 | 34 | 43076 | 529 | 34913292 |
| Solar lentigo | 92.07 | 10.73 | 32 | 43078 | 517 | 34913304 |
| Dysplastic naevus | 91.31 | 10.73 | 31 | 43079 | 465 | 34913356 |
| Off label use | 77.18 | 10.73 | 263 | 42847 | 419261 | 34494560 |
| Polydactyly | 70.60 | 10.73 | 33 | 43077 | 1180 | 34912641 |
| Foetal growth restriction | 69.46 | 10.73 | 50 | 43060 | 4067 | 34909754 |
| Gingival hypertrophy | 66.14 | 10.73 | 36 | 43074 | 1785 | 34912036 |
| Bradycardia | 61.74 | 10.73 | 219 | 42891 | 75199 | 34838622 |
| Drug abuse | 59.26 | 10.73 | 24 | 43086 | 99072 | 34814749 |
| Cerebral infarction | 58.33 | 10.73 | 114 | 42996 | 27341 | 34886480 |
| Renal impairment | 55.26 | 10.73 | 247 | 42863 | 94266 | 34819555 |
| Drug ineffective | 53.77 | 10.73 | 337 | 42773 | 456414 | 34457407 |
| Hyperkalaemia | 52.15 | 10.73 | 196 | 42914 | 69193 | 34844628 |
| Completed suicide | 48.95 | 10.73 | 245 | 42865 | 97923 | 34815898 |
| Atrioventricular septal defect | 48.54 | 10.73 | 16 | 43094 | 218 | 34913603 |
| Blood creatinine increased | 48.04 | 10.73 | 238 | 42872 | 94738 | 34819083 |
| Dandy-Walker syndrome | 45.53 | 10.73 | 15 | 43095 | 204 | 34913617 |
| Aplastic anaemia | 45.47 | 10.73 | 58 | 43052 | 9658 | 34904163 |
| Kidney transplant rejection | 45.36 | 10.73 | 51 | 43059 | 7446 | 34906375 |
| Blood urea increased | 44.97 | 10.73 | 109 | 43001 | 30255 | 34883566 |
| Trisomy 21 | 40.57 | 10.73 | 18 | 43092 | 569 | 34913252 |
| Bezoar | 39.61 | 10.73 | 22 | 43088 | 1135 | 34912686 |
| Pulmonary hypertension | 38.65 | 10.73 | 82 | 43028 | 20842 | 34892979 |
| Neutropenia | 37.81 | 10.73 | 86 | 43024 | 156692 | 34757129 |
| Shock | 37.09 | 10.73 | 88 | 43022 | 24091 | 34889730 |
| Cardiac failure congestive | 36.79 | 10.73 | 201 | 42909 | 83069 | 34830752 |
| Neurodevelopmental disorder | 35.44 | 10.73 | 15 | 43095 | 422 | 34913399 |
| Protein urine present | 34.11 | 10.73 | 37 | 43073 | 5191 | 34908630 |
| Macrocephaly | 33.26 | 10.73 | 15 | 43095 | 493 | 34913328 |
| Oesophageal obstruction | 33.26 | 10.73 | 15 | 43095 | 493 | 34913328 |
| Actinic keratosis | 32.77 | 10.73 | 34 | 43076 | 4533 | 34909288 |
| Proteinuria | 32.08 | 10.73 | 71 | 43039 | 18571 | 34895250 |
| Hepatic function abnormal | 30.60 | 10.73 | 122 | 42988 | 44241 | 34869580 |
| Congenital central nervous system anomaly | 30.37 | 10.73 | 15 | 43095 | 607 | 34913214 |
| Phospholipidosis | 30.09 | 10.73 | 8 | 43102 | 48 | 34913773 |
| Speech disorder developmental | 28.88 | 10.73 | 23 | 43087 | 2177 | 34911644 |
| Drug interaction | 28.38 | 10.73 | 413 | 42697 | 225533 | 34688288 |
| Cardiac arrest | 28.12 | 10.73 | 209 | 42901 | 95950 | 34817871 |
| Aplasia pure red cell | 27.75 | 10.73 | 36 | 43074 | 6096 | 34907725 |
| Chronic kidney disease | 26.58 | 10.73 | 111 | 42999 | 41099 | 34872722 |
| Gene mutation | 25.83 | 10.73 | 18 | 43092 | 1390 | 34912431 |
| Incision site pain | 25.82 | 10.73 | 20 | 43090 | 1818 | 34912003 |
| Foetal exposure timing unspecified | 25.54 | 10.73 | 10 | 43100 | 229 | 34913592 |
| Pre-eclampsia | 25.28 | 10.73 | 7 | 43103 | 50 | 34913771 |
| Hypotonic-hyporesponsive episode | 24.77 | 10.73 | 6 | 43104 | 23 | 34913798 |
| Endoscopy upper gastrointestinal tract abnormal | 24.48 | 10.73 | 7 | 43103 | 57 | 34913764 |
| Systemic scleroderma | 24.38 | 10.73 | 11 | 43099 | 362 | 34913459 |
| Thrombotic cerebral infarction | 24.18 | 10.73 | 11 | 43099 | 369 | 34913452 |
| Oedema | 24.08 | 10.73 | 116 | 42994 | 45625 | 34868196 |
| Blood pressure decreased | 23.86 | 10.73 | 126 | 42984 | 51389 | 34862432 |
| Blood pressure increased | 23.26 | 10.73 | 187 | 42923 | 87915 | 34825906 |
| Haemodilution | 22.29 | 10.73 | 6 | 43104 | 38 | 34913783 |
| Pyelocaliectasis | 22.04 | 10.73 | 15 | 43095 | 1115 | 34912706 |
| Death | 21.05 | 10.73 | 355 | 42755 | 397694 | 34516127 |
| Acute kidney injury | 21.02 | 10.73 | 508 | 42602 | 304480 | 34609341 |
| Oedema peripheral | 20.97 | 10.73 | 233 | 42877 | 119579 | 34794242 |
| Hypertensive crisis | 20.63 | 10.73 | 38 | 43072 | 8713 | 34905108 |
| Hypertension | 20.63 | 10.73 | 258 | 42852 | 136185 | 34777636 |
| Myocardial infarction | 20.52 | 10.73 | 234 | 42876 | 120851 | 34792970 |
| Interstitial lung disease | 20.29 | 10.73 | 144 | 42966 | 65138 | 34848683 |
| Atrioventricular block | 20.27 | 10.73 | 36 | 43074 | 8027 | 34905794 |
| Anti-erythropoietin antibody positive | 20.17 | 10.73 | 13 | 43097 | 882 | 34912939 |
| Malignant hypertension | 20.10 | 10.73 | 12 | 43098 | 710 | 34913111 |
| Attention deficit hyperactivity disorder | 20.09 | 10.73 | 20 | 43090 | 2539 | 34911282 |
| Drug dependence | 19.98 | 10.73 | 3 | 43107 | 24214 | 34889607 |
| Procedural hypertension | 19.88 | 10.73 | 6 | 43104 | 60 | 34913761 |
| Treatment failure | 19.87 | 10.73 | 17 | 43093 | 46680 | 34867141 |
| Renal failure | 19.79 | 10.73 | 247 | 42863 | 130310 | 34783511 |
| Hypotension | 19.67 | 10.73 | 383 | 42727 | 221266 | 34692555 |
| Cutaneous lupus erythematosus | 19.39 | 10.73 | 12 | 43098 | 758 | 34913063 |
| HIV associated nephropathy | 19.20 | 10.73 | 9 | 43101 | 324 | 34913497 |
| Congenital cystic lung | 18.87 | 10.73 | 8 | 43102 | 226 | 34913595 |
| Lymphocyte count decreased | 18.75 | 10.73 | 66 | 43044 | 22556 | 34891265 |
| Lacunar infarction | 18.66 | 10.73 | 21 | 43089 | 3069 | 34910752 |
| Neonatal respiratory failure | 18.34 | 10.73 | 9 | 43101 | 359 | 34913462 |
| Intestinal pseudo-obstruction | 18.17 | 10.73 | 16 | 43094 | 1740 | 34912081 |
| Mixed connective tissue disease | 18.02 | 10.73 | 5 | 43105 | 36 | 34913785 |
| Photosensitivity reaction | 17.83 | 10.73 | 40 | 43070 | 10554 | 34903267 |
| Supernumerary nipple | 17.79 | 10.73 | 5 | 43105 | 38 | 34913783 |
| Blood pressure inadequately controlled | 17.78 | 10.73 | 19 | 43091 | 2621 | 34911200 |
| Atrioventricular block complete | 17.76 | 10.73 | 37 | 43073 | 9282 | 34904539 |
| Metabolic acidosis | 17.66 | 10.73 | 103 | 43007 | 43577 | 34870244 |
| Joint range of motion decreased | 17.55 | 10.73 | 32 | 43078 | 7280 | 34906541 |
| Product use in unapproved indication | 17.43 | 10.73 | 80 | 43030 | 117419 | 34796402 |
| Renal ischaemia | 17.27 | 10.73 | 10 | 43100 | 559 | 34913262 |
| Patent ductus arteriosus | 17.26 | 10.73 | 21 | 43089 | 3333 | 34910488 |
| Apnoeic attack | 17.09 | 10.73 | 9 | 43101 | 417 | 34913404 |
| Cell marker increased | 16.90 | 10.73 | 9 | 43101 | 427 | 34913394 |
| Renal disorder | 16.71 | 10.73 | 69 | 43041 | 25411 | 34888410 |
| Rickets | 16.66 | 10.73 | 5 | 43105 | 49 | 34913772 |
| Hyperuricaemia | 16.59 | 10.73 | 33 | 43077 | 8010 | 34905811 |
| Febrile neutropenia | 16.49 | 10.73 | 100 | 43010 | 136749 | 34777072 |
| Crepitations | 16.43 | 10.73 | 20 | 43090 | 3176 | 34910645 |
| Myocardial ischaemia | 16.38 | 10.73 | 53 | 43057 | 17355 | 34896466 |
| Prinzmetal angina | 16.34 | 10.73 | 12 | 43098 | 1007 | 34912814 |
| Complications of transplanted kidney | 16.26 | 10.73 | 24 | 43086 | 4585 | 34909236 |
| Congenital pulmonary valve atresia | 16.14 | 10.73 | 5 | 43105 | 55 | 34913766 |
| Squamous cell carcinoma of skin | 16.04 | 10.73 | 39 | 43071 | 10842 | 34902979 |
| Brain stem infarction | 15.97 | 10.73 | 13 | 43097 | 1269 | 34912552 |
| Eating disorder symptom | 15.82 | 10.73 | 4 | 43106 | 19 | 34913802 |
| Nausea | 15.79 | 10.73 | 310 | 42800 | 339598 | 34574223 |
| Meningitis staphylococcal | 15.75 | 10.73 | 5 | 43105 | 60 | 34913761 |
| Thrombocytopenia | 15.45 | 10.73 | 121 | 42989 | 156126 | 34757695 |
| Therapeutic product effect incomplete | 15.44 | 10.73 | 24 | 43086 | 50517 | 34863304 |
| Caesarean section | 15.33 | 10.73 | 16 | 43094 | 2148 | 34911673 |
| Polyhydramnios | 15.30 | 10.73 | 7 | 43103 | 238 | 34913583 |
| Pulmonary eosinophilia | 15.19 | 10.73 | 7 | 43103 | 242 | 34913579 |
| Abdominal symptom | 15.09 | 10.73 | 9 | 43101 | 532 | 34913289 |
| Vomiting | 15.03 | 10.73 | 215 | 42895 | 247406 | 34666415 |
| Post procedural urine leak | 14.95 | 10.73 | 6 | 43104 | 147 | 34913674 |
| Azotaemia | 14.90 | 10.73 | 24 | 43086 | 4943 | 34908878 |
| Cerebrovascular accident | 14.86 | 10.73 | 165 | 42945 | 84646 | 34829175 |
| Putamen haemorrhage | 14.73 | 10.73 | 7 | 43103 | 260 | 34913561 |
| Retinopathy of prematurity | 14.61 | 10.73 | 6 | 43104 | 156 | 34913665 |
| Hyphaema | 14.41 | 10.73 | 9 | 43101 | 578 | 34913243 |
| Nephrogenic systemic fibrosis | 14.34 | 10.73 | 21 | 43089 | 3984 | 34909837 |
| Bronchopulmonary dysplasia | 14.25 | 10.73 | 9 | 43101 | 589 | 34913232 |
| Chorioretinopathy | 14.25 | 10.73 | 13 | 43097 | 1480 | 34912341 |
| Wrong technique in product usage process | 14.24 | 10.73 | 14 | 43096 | 35972 | 34877849 |
| Agitation | 14.21 | 10.73 | 31 | 43079 | 57368 | 34856453 |
| Product dose omission issue | 14.14 | 10.73 | 88 | 43022 | 119623 | 34794198 |
| Neonatal respiratory distress | 13.96 | 10.73 | 9 | 43101 | 611 | 34913210 |
| Red blood cells urine positive | 13.95 | 10.73 | 14 | 43096 | 1795 | 34912026 |
| Palatal swelling | 13.83 | 10.73 | 4 | 43106 | 34 | 34913787 |
| Cerebral hyperperfusion syndrome | 13.78 | 10.73 | 5 | 43105 | 92 | 34913729 |
| Lupus-like syndrome | 13.77 | 10.73 | 17 | 43093 | 2739 | 34911082 |
| Maternal exposure during pregnancy | 13.73 | 10.73 | 23 | 43087 | 4895 | 34908926 |
| Pulmonary oedema | 13.70 | 10.73 | 103 | 43007 | 47426 | 34866395 |
| Oesophageal haemorrhage | 13.62 | 10.73 | 12 | 43098 | 1306 | 34912515 |
| Ventricular extrasystoles | 13.58 | 10.73 | 39 | 43071 | 11969 | 34901852 |
| Blindness | 13.54 | 10.73 | 45 | 43065 | 14941 | 34898880 |
| Intentional product use issue | 13.45 | 10.73 | 34 | 43076 | 59782 | 34854039 |
| Naevus flammeus | 13.43 | 10.73 | 6 | 43104 | 193 | 34913628 |
| Congenital hearing disorder | 13.40 | 10.73 | 5 | 43105 | 100 | 34913721 |
| Pituitary tumour recurrent | 13.40 | 10.73 | 5 | 43105 | 100 | 34913721 |
| Neuropathy peripheral | 13.37 | 10.73 | 55 | 43055 | 83208 | 34830613 |
| Hydrocele male infected | 13.26 | 10.73 | 4 | 43106 | 40 | 34913781 |
| Exposure during pregnancy | 13.14 | 10.73 | 32 | 43078 | 8902 | 34904919 |
| Cytokine release syndrome | 12.93 | 10.73 | 6 | 43104 | 22871 | 34890950 |
| Sclerodactylia | 12.83 | 10.73 | 4 | 43106 | 45 | 34913776 |
| Neonatal cholestasis | 12.83 | 10.73 | 4 | 43106 | 45 | 34913776 |
| Renal failure neonatal | 12.83 | 10.73 | 5 | 43105 | 113 | 34913708 |
| Neonatal respiratory distress syndrome | 12.80 | 10.73 | 20 | 43090 | 4014 | 34909807 |
| Altered state of consciousness | 12.73 | 10.73 | 59 | 43051 | 22834 | 34890987 |
| Bradycardia foetal | 12.68 | 10.73 | 7 | 43103 | 357 | 34913464 |
| Acute myocardial infarction | 12.56 | 10.73 | 111 | 42999 | 53608 | 34860213 |
| Infantile apnoea | 12.51 | 10.73 | 10 | 43100 | 951 | 34912870 |
| Fatigue | 12.48 | 10.73 | 355 | 42755 | 370298 | 34543523 |
| BRASH syndrome | 12.47 | 10.73 | 8 | 43102 | 538 | 34913283 |
| Hypocalcaemia | 12.35 | 10.73 | 61 | 43049 | 24228 | 34889593 |
| White blood cell count increased | 12.33 | 10.73 | 90 | 43020 | 41061 | 34872760 |
| Product residue present | 12.23 | 10.73 | 16 | 43094 | 2730 | 34911091 |
| Acute lung injury | 12.22 | 10.73 | 12 | 43098 | 1498 | 34912323 |
| Transplant rejection | 12.16 | 10.73 | 34 | 43076 | 10277 | 34903544 |
| Chronic allograft nephropathy | 12.11 | 10.73 | 11 | 43099 | 1246 | 34912575 |
| Cardiac cirrhosis | 12.03 | 10.73 | 4 | 43106 | 56 | 34913765 |
| Spinal cord abscess | 11.96 | 10.73 | 6 | 43104 | 251 | 34913570 |
| Hypertensive emergency | 11.82 | 10.73 | 10 | 43100 | 1030 | 34912791 |
| Vertebral artery stenosis | 11.74 | 10.73 | 5 | 43105 | 143 | 34913678 |
| Papillary renal cell carcinoma | 11.72 | 10.73 | 6 | 43104 | 262 | 34913559 |
| Maternal drugs affecting foetus | 11.68 | 10.73 | 19 | 43091 | 3946 | 34909875 |
| Serotonin syndrome | 11.62 | 10.73 | 5 | 43105 | 19928 | 34893893 |
| Drug level increased | 11.60 | 10.73 | 56 | 43054 | 22040 | 34891781 |
| Blood pressure systolic | 11.58 | 10.73 | 3 | 43107 | 16 | 34913805 |
| Tubulointerstitial nephritis | 11.56 | 10.73 | 54 | 43056 | 20970 | 34892851 |
| Haemoglobin decreased | 11.48 | 10.73 | 211 | 42899 | 120561 | 34793260 |
| Angina unstable | 11.44 | 10.73 | 36 | 43074 | 11617 | 34902204 |
| Angina pectoris | 11.43 | 10.73 | 72 | 43038 | 31291 | 34882530 |
| Skin tightness | 11.42 | 10.73 | 14 | 43096 | 2239 | 34911582 |
| Hot flush | 11.41 | 10.73 | 4 | 43106 | 18062 | 34895759 |
| Renal artery stenosis | 11.38 | 10.73 | 14 | 43096 | 2247 | 34911574 |
| Hydrops foetalis | 11.24 | 10.73 | 9 | 43101 | 858 | 34912963 |
| Postrenal failure | 11.23 | 10.73 | 7 | 43103 | 448 | 34913373 |
| Skin hypertrophy | 11.22 | 10.73 | 15 | 43095 | 2614 | 34911207 |
| Clonic convulsion | 11.16 | 10.73 | 8 | 43102 | 646 | 34913175 |
| Sedation | 11.13 | 10.73 | 6 | 43104 | 21000 | 34892821 |
| Kidney infection | 10.97 | 10.73 | 22 | 43088 | 5372 | 34908449 |
| Adverse drug reaction | 10.95 | 10.73 | 12 | 43098 | 29330 | 34884491 |
| Neutrophil count increased | 10.91 | 10.73 | 46 | 43064 | 17100 | 34896721 |
| Cerebrovascular insufficiency | 10.89 | 10.73 | 3 | 43107 | 21 | 34913800 |
| Hepatocellular injury | 10.85 | 10.73 | 7 | 43103 | 22204 | 34891617 |
| Peripheral arterial occlusive disease | 10.82 | 10.73 | 23 | 43087 | 5851 | 34907970 |
| Nodal rhythm | 10.82 | 10.73 | 11 | 43099 | 1432 | 34912389 |
| Anaemia neonatal | 10.78 | 10.73 | 6 | 43104 | 311 | 34913510 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Premature delivery | 504.76 | 9.64 | 322 | 91074 | 23145 | 79629847 |
| Exposure during pregnancy | 260.76 | 9.64 | 438 | 90958 | 100694 | 79552298 |
| Pre-eclampsia | 142.45 | 9.64 | 93 | 91303 | 6948 | 79646044 |
| Renal impairment | 137.84 | 9.64 | 446 | 90950 | 157337 | 79495655 |
| Maternal exposure during pregnancy | 116.58 | 9.64 | 383 | 91013 | 136155 | 79516837 |
| Cerebral infarction | 112.58 | 9.64 | 194 | 91202 | 45482 | 79607510 |
| Bradycardia | 102.36 | 9.64 | 365 | 91031 | 135192 | 79517800 |
| Cardiac failure congestive | 99.58 | 9.64 | 374 | 91022 | 142028 | 79510964 |
| Hypotension | 99.52 | 9.64 | 852 | 90544 | 439465 | 79213527 |
| Alopecia | 93.14 | 9.64 | 77 | 91319 | 231278 | 79421714 |
| Dysplastic naevus | 88.01 | 9.64 | 31 | 91365 | 564 | 79652428 |
| Photodermatosis | 87.06 | 9.64 | 35 | 91361 | 929 | 79652063 |
| Aplastic anaemia | 86.97 | 9.64 | 105 | 91291 | 17800 | 79635192 |
| Blood creatinine increased | 85.98 | 9.64 | 379 | 91017 | 154678 | 79498314 |
| Shock | 83.48 | 9.64 | 166 | 91230 | 43382 | 79609610 |
| Hyperkalaemia | 82.09 | 9.64 | 303 | 91093 | 114095 | 79538897 |
| Drug abuse | 81.97 | 9.64 | 42 | 91354 | 162649 | 79490343 |
| Blood pressure inadequately controlled | 81.81 | 9.64 | 63 | 91333 | 6114 | 79646878 |
| Neovascularisation | 81.64 | 9.64 | 36 | 91360 | 1209 | 79651783 |
| Proteinuria | 81.34 | 9.64 | 139 | 91257 | 32363 | 79620629 |
| Oedema peripheral | 78.19 | 9.64 | 526 | 90870 | 251762 | 79401230 |
| Premature labour | 76.61 | 9.64 | 69 | 91327 | 8321 | 79644671 |
| Therapeutic product effect decreased | 74.43 | 9.64 | 48 | 91348 | 163815 | 79489177 |
| Solar lentigo | 71.85 | 9.64 | 32 | 91364 | 1101 | 79651891 |
| Pericarditis | 71.36 | 9.64 | 16 | 91380 | 104220 | 79548772 |
| Pemphigus | 70.81 | 9.64 | 14 | 91382 | 99568 | 79553424 |
| Drug interaction | 66.13 | 9.64 | 747 | 90649 | 414436 | 79238556 |
| Blood urea increased | 65.24 | 9.64 | 161 | 91235 | 48629 | 79604363 |
| Glossodynia | 64.72 | 9.64 | 19 | 91377 | 103318 | 79549674 |
| Blood pressure increased | 63.87 | 9.64 | 438 | 90958 | 210922 | 79442070 |
| Duodenal ulcer perforation | 63.22 | 9.64 | 3 | 91393 | 66208 | 79586784 |
| Wound | 63.13 | 9.64 | 27 | 91369 | 116152 | 79536840 |
| Neutropenia | 62.56 | 9.64 | 149 | 91247 | 287561 | 79365431 |
| Gingival hypertrophy | 62.34 | 9.64 | 41 | 91355 | 3101 | 79649891 |
| Hypersensitivity | 58.46 | 9.64 | 134 | 91262 | 262105 | 79390887 |
| Arthropathy | 56.46 | 9.64 | 72 | 91324 | 177039 | 79475953 |
| Hepatic function abnormal | 53.57 | 9.64 | 195 | 91201 | 72912 | 79580080 |
| Pulmonary oedema | 52.95 | 9.64 | 221 | 91175 | 88033 | 79564959 |
| Discomfort | 52.80 | 9.64 | 40 | 91356 | 125577 | 79527415 |
| Blood pressure decreased | 52.75 | 9.64 | 240 | 91156 | 99226 | 79553766 |
| Joint swelling | 52.60 | 9.64 | 163 | 91233 | 288483 | 79364509 |
| Primary hyperaldosteronism | 51.62 | 9.64 | 15 | 91381 | 141 | 79652851 |
| Rheumatoid factor positive | 50.51 | 9.64 | 5 | 91391 | 59834 | 79593158 |
| Completed suicide | 49.45 | 9.64 | 464 | 90932 | 245303 | 79407689 |
| Infusion related reaction | 49.43 | 9.64 | 120 | 91276 | 230117 | 79422875 |
| Cardiac failure | 49.23 | 9.64 | 325 | 91071 | 154517 | 79498475 |
| Helicobacter infection | 49.14 | 9.64 | 10 | 91386 | 69694 | 79583298 |
| Caesarean section | 49.02 | 9.64 | 66 | 91330 | 12469 | 79640523 |
| Foetal growth restriction | 47.85 | 9.64 | 30 | 91366 | 2089 | 79650903 |
| Off label use | 47.23 | 9.64 | 744 | 90652 | 906471 | 78746521 |
| Cerebrovascular accident | 47 | 9.64 | 322 | 91074 | 154970 | 79498022 |
| Kidney transplant rejection | 46.39 | 9.64 | 58 | 91338 | 10188 | 79642804 |
| Cardiac arrest | 45.26 | 9.64 | 345 | 91051 | 171751 | 79481241 |
| Hypertensive crisis | 44.49 | 9.64 | 83 | 91313 | 20687 | 79632305 |
| Muscle injury | 43.91 | 9.64 | 3 | 91393 | 48558 | 79604434 |
| Myocardial infarction | 43.43 | 9.64 | 360 | 91036 | 183769 | 79469223 |
| Wrist deformity | 42.91 | 9.64 | 28 | 91368 | 2089 | 79650903 |
| Drug ineffective | 42.70 | 9.64 | 930 | 90466 | 1079983 | 78573009 |
| Angina unstable | 41.77 | 9.64 | 71 | 91325 | 16456 | 79636536 |
| Treatment failure | 41.40 | 9.64 | 83 | 91313 | 170403 | 79482589 |
| Renal failure | 41.21 | 9.64 | 381 | 91015 | 200587 | 79452405 |
| Polyhydramnios | 40.48 | 9.64 | 25 | 91371 | 1695 | 79651297 |
| Metabolic acidosis | 40.00 | 9.64 | 194 | 91202 | 82335 | 79570657 |
| Hypertension | 39.22 | 9.64 | 564 | 90832 | 330428 | 79322564 |
| Chronic kidney disease | 39.17 | 9.64 | 165 | 91231 | 65989 | 79587003 |
| Bladder prolapse | 39.14 | 9.64 | 23 | 91373 | 1424 | 79651568 |
| Synovitis | 38.68 | 9.64 | 71 | 91325 | 150663 | 79502329 |
| Adverse drug reaction | 38.41 | 9.64 | 14 | 91382 | 66378 | 79586614 |
| Scleroderma | 38.33 | 9.64 | 39 | 91357 | 5471 | 79647521 |
| Blood aldosterone increased | 38.05 | 9.64 | 13 | 91383 | 215 | 79652777 |
| Tubulointerstitial nephritis | 37.89 | 9.64 | 113 | 91283 | 38122 | 79614870 |
| Pulmonary hypertension | 37.58 | 9.64 | 131 | 91265 | 47949 | 79605043 |
| Bezoar | 36.88 | 9.64 | 28 | 91368 | 2660 | 79650332 |
| Impaired healing | 36.72 | 9.64 | 28 | 91368 | 87627 | 79565365 |
| Renal artery stenosis | 36.55 | 9.64 | 31 | 91365 | 3451 | 79649541 |
| Drug intolerance | 36.48 | 9.64 | 167 | 91229 | 263952 | 79389040 |
| Acute kidney injury | 36.26 | 9.64 | 814 | 90582 | 518590 | 79134402 |
| Systemic lupus erythematosus | 35.82 | 9.64 | 52 | 91344 | 121097 | 79531895 |
| Lower respiratory tract infection | 35.77 | 9.64 | 58 | 91338 | 129162 | 79523830 |
| Hyperuricaemia | 35.69 | 9.64 | 55 | 91341 | 11744 | 79641248 |
| Anuria | 35.56 | 9.64 | 76 | 91320 | 20887 | 79632105 |
| Angina pectoris | 35.40 | 9.64 | 135 | 91261 | 51597 | 79601395 |
| Atrioventricular block | 35.06 | 9.64 | 60 | 91336 | 13981 | 79639011 |
| Oedema | 35.02 | 9.64 | 246 | 91150 | 119334 | 79533658 |
| Intestinal angioedema | 34.83 | 9.64 | 18 | 91378 | 865 | 79652127 |
| Superimposed pre-eclampsia | 34.64 | 9.64 | 6 | 91390 | 0 | 79652992 |
| Blood pressure systolic abnormal | 34.57 | 9.64 | 67 | 91329 | 17180 | 79635812 |
| Malignant hypertension | 34.22 | 9.64 | 22 | 91374 | 1600 | 79651392 |
| Dialysis | 33.73 | 9.64 | 69 | 91327 | 18393 | 79634599 |
| Actinic keratosis | 33.62 | 9.64 | 38 | 91358 | 6004 | 79646988 |
| Phaeochromocytoma | 33.43 | 9.64 | 16 | 91380 | 651 | 79652341 |
| Rectal prolapse | 32.82 | 9.64 | 24 | 91372 | 2154 | 79650838 |
| Psoriatic arthropathy | 32.56 | 9.64 | 25 | 91371 | 77974 | 79575018 |
| BRASH syndrome | 32.44 | 9.64 | 18 | 91378 | 999 | 79651993 |
| Contraindicated product administered | 32.33 | 9.64 | 84 | 91312 | 157454 | 79495538 |
| Fatigue | 31.90 | 9.64 | 817 | 90579 | 928910 | 78724082 |
| Wrong technique in product usage process | 31.72 | 9.64 | 23 | 91373 | 73852 | 79579140 |
| Acute myocardial infarction | 31.70 | 9.64 | 173 | 91223 | 76863 | 79576129 |
| Transfusion | 31.32 | 9.64 | 73 | 91323 | 21257 | 79631735 |
| Intentional product use issue | 31.30 | 9.64 | 81 | 91315 | 152031 | 79500961 |
| Hepatic enzyme increased | 31.24 | 9.64 | 106 | 91290 | 182504 | 79470488 |
| Sinusitis | 31.11 | 9.64 | 117 | 91279 | 195384 | 79457608 |
| Oligohydramnios | 31.03 | 9.64 | 28 | 91368 | 3384 | 79649608 |
| Eclampsia | 30.98 | 9.64 | 11 | 91385 | 205 | 79652787 |
| Blood pressure diastolic abnormal | 30.73 | 9.64 | 68 | 91328 | 19134 | 79633858 |
| Fibromyalgia | 30.38 | 9.64 | 18 | 91378 | 64322 | 79588670 |
| Aortic dissection | 29.86 | 9.64 | 30 | 91366 | 4145 | 79648847 |
| Systemic scleroderma | 29.71 | 9.64 | 18 | 91378 | 1179 | 79651813 |
| Acute pulmonary oedema | 29.40 | 9.64 | 56 | 91340 | 14174 | 79638818 |
| Product use issue | 29.37 | 9.64 | 132 | 91264 | 209690 | 79443302 |
| Incision site pain | 29.30 | 9.64 | 25 | 91371 | 2805 | 79650187 |
| Lacunar infarction | 29.04 | 9.64 | 35 | 91361 | 5922 | 79647070 |
| Protein urine present | 29.01 | 9.64 | 46 | 91350 | 10066 | 79642926 |
| Intestinal pseudo-obstruction | 28.98 | 9.64 | 24 | 91372 | 2585 | 79650407 |
| Knee arthroplasty | 28.88 | 9.64 | 7 | 91389 | 43241 | 79609751 |
| Hypergammaglobulinaemia | 28.81 | 9.64 | 15 | 91381 | 732 | 79652260 |
| Blood pressure systolic increased | 28.62 | 9.64 | 152 | 91244 | 66834 | 79586158 |
| Haemoglobin decreased | 28.51 | 9.64 | 384 | 91012 | 221735 | 79431257 |
| Renin decreased | 28.34 | 9.64 | 9 | 91387 | 117 | 79652875 |
| Irritable bowel syndrome | 27.21 | 9.64 | 19 | 91377 | 62222 | 79590770 |
| Rash | 27.15 | 9.64 | 483 | 90913 | 577875 | 79075117 |
| Uraemic encephalopathy | 27.08 | 9.64 | 14 | 91382 | 673 | 79652319 |
| Atrioventricular block first degree | 26.86 | 9.64 | 50 | 91346 | 12441 | 79640551 |
| Peripartum cardiomyopathy | 26.85 | 9.64 | 9 | 91387 | 140 | 79652852 |
| Febrile neutropenia | 26.84 | 9.64 | 155 | 91241 | 230844 | 79422148 |
| Paradoxical drug reaction | 26.83 | 9.64 | 37 | 91359 | 7148 | 79645844 |
| Injection site erythema | 26.81 | 9.64 | 30 | 91366 | 78167 | 79574825 |
| Aplasia pure red cell | 25.90 | 9.64 | 38 | 91358 | 7772 | 79645220 |
| Altered state of consciousness | 25.70 | 9.64 | 109 | 91287 | 43713 | 79609279 |
| Heart rate decreased | 25.70 | 9.64 | 153 | 91243 | 70163 | 79582829 |
| CD30 expression | 25.67 | 9.64 | 7 | 91389 | 51 | 79652941 |
| Dyspnoea exertional | 25.41 | 9.64 | 179 | 91217 | 86894 | 79566098 |
| White blood cell count increased | 25.14 | 9.64 | 159 | 91237 | 74474 | 79578518 |
| Therapeutic product effect incomplete | 25.06 | 9.64 | 81 | 91315 | 141564 | 79511428 |
| Psoriasis | 24.99 | 9.64 | 40 | 91356 | 89547 | 79563445 |
| Coronary artery disease | 24.92 | 9.64 | 144 | 91252 | 65330 | 79587662 |
| Drug dependence | 24.62 | 9.64 | 8 | 91388 | 40761 | 79612231 |
| Atrioventricular block complete | 24.56 | 9.64 | 57 | 91339 | 16553 | 79636439 |
| Diabetic nephropathy | 24.50 | 9.64 | 23 | 91373 | 2924 | 79650068 |
| Oesophageal obstruction | 24.37 | 9.64 | 15 | 91381 | 1011 | 79651981 |
| Abdominal discomfort | 24.17 | 9.64 | 178 | 91218 | 250549 | 79402443 |
| Infection | 24.08 | 9.64 | 170 | 91226 | 241542 | 79411450 |
| Drug dispensed to wrong patient | 23.91 | 9.64 | 13 | 91383 | 693 | 79652299 |
| Peripheral vascular disorder | 23.69 | 9.64 | 37 | 91359 | 7993 | 79644999 |
| Thrombotic cerebral infarction | 23.54 | 9.64 | 12 | 91384 | 560 | 79652432 |
| Sleep disorder | 23.20 | 9.64 | 39 | 91357 | 85638 | 79567354 |
| Renal hypoplasia | 23.06 | 9.64 | 5 | 91391 | 11 | 79652981 |
| Azotaemia | 22.85 | 9.64 | 37 | 91359 | 8239 | 79644753 |
| Low birth weight baby | 22.58 | 9.64 | 12 | 91384 | 611 | 79652381 |
| Endometritis | 22.27 | 9.64 | 13 | 91383 | 795 | 79652197 |
| Pain in jaw | 22.01 | 9.64 | 108 | 91288 | 46043 | 79606949 |
| Hypervolaemia | 21.88 | 9.64 | 102 | 91294 | 42588 | 79610404 |
| Pain | 21.60 | 9.64 | 628 | 90768 | 703174 | 78949818 |
| Premature baby | 21.42 | 9.64 | 24 | 91372 | 3756 | 79649236 |
| Finger amputation | 21.36 | 9.64 | 12 | 91384 | 682 | 79652310 |
| Umbilical cord vascular disorder | 21.25 | 9.64 | 5 | 91391 | 18 | 79652974 |
| Myocardial ischaemia | 21.23 | 9.64 | 71 | 91325 | 25448 | 79627544 |
| Sedation | 21.20 | 9.64 | 17 | 91379 | 51878 | 79601114 |
| Product complaint | 21.05 | 9.64 | 47 | 91349 | 13302 | 79639690 |
| Platelet transfusion | 20.87 | 9.64 | 19 | 91377 | 2323 | 79650669 |
| Intentional self-injury | 20.22 | 9.64 | 6 | 91390 | 32413 | 79620579 |
| Hypertensive encephalopathy | 19.93 | 9.64 | 13 | 91383 | 969 | 79652023 |
| Hypertensive emergency | 19.90 | 9.64 | 20 | 91376 | 2765 | 79650227 |
| Endoscopy upper gastrointestinal tract abnormal | 19.80 | 9.64 | 6 | 91390 | 66 | 79652926 |
| Wheezing | 19.75 | 9.64 | 68 | 91328 | 116596 | 79536396 |
| HIV associated nephropathy | 19.72 | 9.64 | 9 | 91387 | 328 | 79652664 |
| Weight increased | 19.67 | 9.64 | 213 | 91183 | 277173 | 79375819 |
| Foetal death | 19.60 | 9.64 | 34 | 91362 | 8010 | 79644982 |
| Left ventricular hypertrophy | 19.48 | 9.64 | 41 | 91355 | 11150 | 79641842 |
| Phospholipidosis | 19.37 | 9.64 | 8 | 91388 | 228 | 79652764 |
| Brain stem infarction | 19.35 | 9.64 | 17 | 91379 | 1984 | 79651008 |
| General physical health deterioration | 19.26 | 9.64 | 212 | 91184 | 275026 | 79377966 |
| Preterm premature rupture of membranes | 19.12 | 9.64 | 14 | 91382 | 1259 | 79651733 |
| Oesophageal haemorrhage | 19.10 | 9.64 | 16 | 91380 | 1751 | 79651241 |
| Dyspnoea | 19.09 | 9.64 | 1181 | 90215 | 855844 | 78797148 |
| Stillbirth | 18.89 | 9.64 | 23 | 91373 | 3932 | 79649060 |
| Respiratory tract inflammation | 18.88 | 9.64 | 12 | 91384 | 856 | 79652136 |
| Putamen haemorrhage | 18.85 | 9.64 | 10 | 91386 | 507 | 79652485 |
| Injection site inflammation | 18.79 | 9.64 | 23 | 91373 | 3953 | 79649039 |
| Cognitive disorder | 18.78 | 9.64 | 32 | 91364 | 69894 | 79583098 |
| Arthralgia | 18.61 | 9.64 | 506 | 90890 | 571297 | 79081695 |
| Pulmonary arterial hypertension | 18.57 | 9.64 | 73 | 91323 | 28293 | 79624699 |
| Electrocardiogram PR prolongation | 18.50 | 9.64 | 15 | 91381 | 1568 | 79651424 |
| Interstitial lung disease | 18.50 | 9.64 | 204 | 91192 | 112396 | 79540596 |
| Sclerodactylia | 18.43 | 9.64 | 7 | 91389 | 159 | 79652833 |
| Vascular resistance systemic increased | 18.39 | 9.64 | 4 | 91392 | 9 | 79652983 |
| Nephrotic syndrome | 18.37 | 9.64 | 40 | 91356 | 11134 | 79641858 |
| Maternal condition affecting foetus | 18.35 | 9.64 | 7 | 91389 | 161 | 79652831 |
| Hip arthroplasty | 18.34 | 9.64 | 9 | 91387 | 35747 | 79617245 |
| Thrombocytopenia | 18.29 | 9.64 | 205 | 91191 | 265054 | 79387938 |
| Multiple sclerosis relapse | 18.08 | 9.64 | 16 | 91380 | 46517 | 79606475 |
| Neuropathy peripheral | 17.95 | 9.64 | 92 | 91304 | 141213 | 79511779 |
| Pemphigoid | 17.85 | 9.64 | 48 | 91348 | 15267 | 79637725 |
| Injection site reaction | 17.73 | 9.64 | 22 | 91374 | 54763 | 79598229 |
| COVID-19 | 17.67 | 9.64 | 107 | 91289 | 157567 | 79495425 |
| Renal disorder | 17.62 | 9.64 | 95 | 91301 | 42010 | 79610982 |
| Product residue present | 17.60 | 9.64 | 21 | 91375 | 3515 | 79649477 |
| Urticaria | 17.59 | 9.64 | 132 | 91264 | 185069 | 79467923 |
| Ventricular extrasystoles | 17.45 | 9.64 | 56 | 91340 | 19648 | 79633344 |
| Scleroderma renal crisis | 17.44 | 9.64 | 10 | 91386 | 591 | 79652401 |
| Prinzmetal angina | 17.41 | 9.64 | 15 | 91381 | 1705 | 79651287 |
| Haemodialysis | 17.34 | 9.64 | 53 | 91343 | 18115 | 79634877 |
| Blood pressure fluctuation | 17.29 | 9.64 | 134 | 91262 | 67011 | 79585981 |
| HELLP syndrome | 17.17 | 9.64 | 11 | 91385 | 795 | 79652197 |
| Barotrauma | 17.16 | 9.64 | 7 | 91389 | 193 | 79652799 |
| Thermal burn | 17.10 | 9.64 | 30 | 91366 | 7130 | 79645862 |
| Photosensitivity reaction | 16.88 | 9.64 | 58 | 91338 | 21069 | 79631923 |
| Injection site pain | 16.80 | 9.64 | 84 | 91312 | 129754 | 79523238 |
| Small for dates baby | 16.78 | 9.64 | 9 | 91387 | 467 | 79652525 |
| Swollen joint count increased | 16.77 | 9.64 | 3 | 91393 | 22924 | 79630068 |
| Condition aggravated | 16.67 | 9.64 | 442 | 90954 | 500682 | 79152310 |
| Skin hypertrophy | 16.37 | 9.64 | 24 | 91372 | 4904 | 79648088 |
| Squamous cell carcinoma of skin | 16.37 | 9.64 | 44 | 91352 | 13989 | 79639003 |
| Nephrogenic systemic fibrosis | 16.28 | 9.64 | 27 | 91369 | 6133 | 79646859 |
| Gestational hypertension | 16.27 | 9.64 | 15 | 91381 | 1864 | 79651128 |
| Nodal rhythm | 16.24 | 9.64 | 19 | 91377 | 3116 | 79649876 |
| Vitamin D decreased | 16.20 | 9.64 | 35 | 91361 | 9690 | 79643302 |
| Arrhythmia | 16.18 | 9.64 | 123 | 91273 | 61149 | 79591843 |
| Nodular regenerative hyperplasia | 16.13 | 9.64 | 13 | 91383 | 1348 | 79651644 |
| Platelet count decreased | 16.12 | 9.64 | 313 | 91083 | 194351 | 79458641 |
| Hypocalcaemia | 15.98 | 9.64 | 105 | 91291 | 49819 | 79603173 |
| Nephrogenic anaemia | 15.95 | 9.64 | 21 | 91375 | 3881 | 79649111 |
| Myocardial depression | 15.89 | 9.64 | 9 | 91387 | 520 | 79652472 |
| Tricuspid valve incompetence | 15.65 | 9.64 | 54 | 91342 | 19658 | 79633334 |
| Complications of transplanted kidney | 15.63 | 9.64 | 27 | 91369 | 6339 | 79646653 |
| Product use in unapproved indication | 15.52 | 9.64 | 198 | 91198 | 250161 | 79402831 |
| Hepatocellular injury | 15.52 | 9.64 | 19 | 91377 | 47574 | 79605418 |
| Telangiectasia | 15.41 | 9.64 | 13 | 91383 | 1436 | 79651556 |
| Diabetes mellitus | 15.24 | 9.64 | 147 | 91249 | 78243 | 79574749 |
| Peritoneal dialysis complication | 15.18 | 9.64 | 16 | 91380 | 2338 | 79650654 |
| Haemodilution | 15.04 | 9.64 | 6 | 91390 | 156 | 79652836 |
| Gastroenteritis | 15.01 | 9.64 | 78 | 91318 | 34004 | 79618988 |
| Hyperventilation | 15.00 | 9.64 | 30 | 91366 | 7869 | 79645123 |
| Premature separation of placenta | 14.97 | 9.64 | 12 | 91384 | 1234 | 79651758 |
| Neutrophil count increased | 14.89 | 9.64 | 70 | 91326 | 29326 | 79623666 |
| Urine output decreased | 14.86 | 9.64 | 50 | 91346 | 17972 | 79635020 |
| Incorrect route of product administration | 14.83 | 9.64 | 11 | 91385 | 34918 | 79618074 |
| Blood lactate dehydrogenase increased | 14.81 | 9.64 | 86 | 91310 | 39084 | 79613908 |
| Porphyria acute | 14.76 | 9.64 | 13 | 91383 | 1522 | 79651470 |
| Renal atrophy | 14.71 | 9.64 | 14 | 91382 | 1811 | 79651181 |
| Amniotic cavity infection | 14.51 | 9.64 | 10 | 91386 | 817 | 79652175 |
| Accidental exposure to product | 14.45 | 9.64 | 9 | 91387 | 31313 | 79621679 |
| Cytokine release syndrome | 14.44 | 9.64 | 12 | 91384 | 35986 | 79617006 |
| Swelling | 14.34 | 9.64 | 169 | 91227 | 216542 | 79436450 |
| Lymphocyte count decreased | 14.26 | 9.64 | 98 | 91298 | 47191 | 79605801 |
| Nasopharyngitis | 14.22 | 9.64 | 205 | 91191 | 253676 | 79399316 |
| Peritoneal dialysis | 14.20 | 9.64 | 10 | 91386 | 846 | 79652146 |
| Foot deformity | 14.05 | 9.64 | 5 | 91391 | 24069 | 79628923 |
| Diverticulum intestinal haemorrhagic | 14.01 | 9.64 | 20 | 91376 | 3991 | 79649001 |
| Aggression | 13.98 | 9.64 | 23 | 91373 | 50935 | 79602057 |
| Ventricular hypertrophy | 13.96 | 9.64 | 27 | 91369 | 6911 | 79646081 |
| Accidental exposure to product by child | 13.95 | 9.64 | 17 | 91379 | 2909 | 79650083 |
| End stage renal disease | 13.94 | 9.64 | 38 | 91358 | 12182 | 79640810 |
| Hot flush | 13.94 | 9.64 | 26 | 91370 | 54851 | 79598141 |
| Blood pressure diastolic decreased | 13.90 | 9.64 | 70 | 91326 | 30146 | 79622846 |
| Human chorionic gonadotropin positive | 13.82 | 9.64 | 4 | 91392 | 37 | 79652955 |
| Heliotrope rash | 13.76 | 9.64 | 6 | 91390 | 196 | 79652796 |
| Procedural hypertension | 13.75 | 9.64 | 7 | 91389 | 326 | 79652666 |
| Hyphaema | 13.71 | 9.64 | 10 | 91386 | 894 | 79652098 |
| Hyperplasia adrenal | 13.64 | 9.64 | 4 | 91392 | 39 | 79652953 |
| Mucosal erosion | 13.62 | 9.64 | 15 | 91381 | 2303 | 79650689 |
| Neutropenic sepsis | 13.60 | 9.64 | 7 | 91389 | 27057 | 79625935 |
| Renal ischaemia | 13.56 | 9.64 | 11 | 91385 | 1151 | 79651841 |
| Meningitis staphylococcal | 13.53 | 9.64 | 5 | 91391 | 105 | 79652887 |
| Hepatic rupture | 13.53 | 9.64 | 5 | 91391 | 105 | 79652887 |
| Palpitations | 13.50 | 9.64 | 212 | 91184 | 126398 | 79526594 |
| Hypoaesthesia teeth | 13.46 | 9.64 | 4 | 91392 | 41 | 79652951 |
| Anti-erythropoietin antibody positive | 13.36 | 9.64 | 9 | 91387 | 708 | 79652284 |
| Peritonitis bacterial | 13.24 | 9.64 | 32 | 91364 | 9535 | 79643457 |
| Blood albumin decreased | 13.22 | 9.64 | 59 | 91337 | 24184 | 79628808 |
| Diabetic retinopathy | 13.14 | 9.64 | 17 | 91379 | 3089 | 79649903 |
| Fluid retention | 13.12 | 9.64 | 130 | 91266 | 69679 | 79583313 |
| Shunt occlusion | 13.01 | 9.64 | 12 | 91384 | 1492 | 79651500 |
| Sinus arrhythmia | 13.00 | 9.64 | 14 | 91382 | 2096 | 79650896 |
| Intracardiac mass | 12.99 | 9.64 | 6 | 91390 | 225 | 79652767 |
| Hypermagnesaemia | 12.90 | 9.64 | 11 | 91385 | 1233 | 79651759 |
| Decreased appetite | 12.89 | 9.64 | 497 | 90899 | 341921 | 79311071 |
| Paranasal sinus inflammation | 12.89 | 9.64 | 6 | 91390 | 229 | 79652763 |
| Live birth | 12.89 | 9.64 | 49 | 91347 | 18695 | 79634297 |
| Arteriosclerosis | 12.83 | 9.64 | 48 | 91348 | 18179 | 79634813 |
| Haemoperitoneum | 12.80 | 9.64 | 20 | 91376 | 4323 | 79648669 |
| Illness | 12.75 | 9.64 | 21 | 91375 | 46490 | 79606502 |
| Transferrin decreased | 12.69 | 9.64 | 7 | 91389 | 384 | 79652608 |
| Cerebral hyperperfusion syndrome | 12.64 | 9.64 | 5 | 91391 | 127 | 79652865 |
| Injection site pruritus | 12.64 | 9.64 | 18 | 91378 | 42265 | 79610727 |
| Cardiac failure acute | 12.62 | 9.64 | 49 | 91347 | 18880 | 79634112 |
| Product substitution error | 12.59 | 9.64 | 4 | 91392 | 52 | 79652940 |
| Bradycardia foetal | 12.57 | 9.64 | 5 | 91391 | 129 | 79652863 |
| Brain natriuretic peptide increased | 12.57 | 9.64 | 30 | 91366 | 8870 | 79644122 |
| Device expulsion | 12.54 | 9.64 | 7 | 91389 | 25854 | 79627138 |
| Prescribed overdose | 12.48 | 9.64 | 15 | 91381 | 37868 | 79615124 |
| Hypoproteinaemia | 12.44 | 9.64 | 19 | 91377 | 4027 | 79648965 |
| Chorioretinopathy | 12.36 | 9.64 | 14 | 91382 | 2217 | 79650775 |
| Post transplant distal limb syndrome | 12.32 | 9.64 | 8 | 91388 | 592 | 79652400 |
| Hydronephrosis | 12.31 | 9.64 | 46 | 91350 | 17408 | 79635584 |
| Pleural effusion | 12.17 | 9.64 | 234 | 91162 | 145028 | 79507964 |
| Rheumatoid arthritis | 12.14 | 9.64 | 167 | 91229 | 208303 | 79444689 |
| Cerebral haemorrhage | 12.14 | 9.64 | 110 | 91286 | 57563 | 79595429 |
| Red blood cells urine positive | 12.12 | 9.64 | 21 | 91375 | 4942 | 79648050 |
| Low density lipoprotein increased | 12.11 | 9.64 | 29 | 91367 | 8593 | 79644399 |
| Ileus paralytic | 12.08 | 9.64 | 31 | 91365 | 9589 | 79643403 |
| Ear infection | 12.03 | 9.64 | 13 | 91383 | 34419 | 79618573 |
| Papillary renal cell carcinoma | 11.99 | 9.64 | 6 | 91390 | 269 | 79652723 |
| Immunodeficiency | 11.91 | 9.64 | 5 | 91391 | 21763 | 79631229 |
| Post procedural urine leak | 11.90 | 9.64 | 5 | 91391 | 149 | 79652843 |
| Vomiting | 11.88 | 9.64 | 633 | 90763 | 665195 | 78987797 |
| Shunt stenosis | 11.84 | 9.64 | 11 | 91385 | 1380 | 79651612 |
| Peripheral arterial occlusive disease | 11.84 | 9.64 | 28 | 91368 | 8230 | 79644762 |
| Muscle spasticity | 11.65 | 9.64 | 5 | 91391 | 21470 | 79631522 |
| Renal-limited thrombotic microangiopathy | 11.59 | 9.64 | 5 | 91391 | 159 | 79652833 |
| Apnoeic attack | 11.47 | 9.64 | 8 | 91388 | 666 | 79652326 |
| Glomerular filtration rate decreased | 11.45 | 9.64 | 54 | 91342 | 22648 | 79630344 |
| Ill-defined disorder | 11.42 | 9.64 | 38 | 91358 | 65837 | 79587155 |
| Cardiomegaly | 11.39 | 9.64 | 60 | 91336 | 26292 | 79626700 |
| Peripheral ischaemia | 11.38 | 9.64 | 30 | 91366 | 9427 | 79643565 |
| Blood glucose increased | 11.32 | 9.64 | 190 | 91206 | 114785 | 79538207 |
| Pulmonary embolism | 11.30 | 9.64 | 134 | 91262 | 171520 | 79481472 |
| Loss of personal independence in daily activities | 11.28 | 9.64 | 70 | 91326 | 102510 | 79550482 |
| Renal cyst haemorrhage | 11.28 | 9.64 | 8 | 91388 | 684 | 79652308 |
| Crepitations | 11.28 | 9.64 | 31 | 91365 | 9986 | 79643006 |
| Sinus bradycardia | 11.27 | 9.64 | 58 | 91338 | 25189 | 79627803 |
| Joint range of motion decreased | 11.26 | 9.64 | 71 | 91325 | 33211 | 79619781 |
| Dehydration | 11.26 | 9.64 | 368 | 91028 | 247819 | 79405173 |
| Lip haemorrhage | 11.26 | 9.64 | 10 | 91386 | 1184 | 79651808 |
| Frostbite | 11.25 | 9.64 | 5 | 91391 | 171 | 79652821 |
| Laboratory test interference | 11.21 | 9.64 | 10 | 91386 | 1191 | 79651801 |
| Cardiac failure chronic | 11.12 | 9.64 | 33 | 91363 | 11102 | 79641890 |
| Chest discomfort | 11.10 | 9.64 | 221 | 91175 | 137823 | 79515169 |
| Musculoskeletal stiffness | 11.00 | 9.64 | 138 | 91258 | 174870 | 79478122 |
| Liver injury | 10.99 | 9.64 | 31 | 91365 | 56583 | 79596409 |
| Gastric cancer | 10.96 | 9.64 | 31 | 91365 | 10148 | 79642844 |
| Periodontitis | 10.95 | 9.64 | 19 | 91377 | 4477 | 79648515 |
| Blister | 10.95 | 9.64 | 86 | 91310 | 119390 | 79533602 |
| Cholangitis acute | 10.94 | 9.64 | 11 | 91385 | 1521 | 79651471 |
| Electrocardiogram QRS complex shortened | 10.90 | 9.64 | 8 | 91388 | 722 | 79652270 |
| Lactic acidosis | 10.88 | 9.64 | 126 | 91270 | 70233 | 79582759 |
| Pneumonia | 10.88 | 9.64 | 888 | 90508 | 659358 | 78993634 |
| Dermatophytosis of nail | 10.86 | 9.64 | 5 | 91391 | 186 | 79652806 |
| Poisoning deliberate | 10.84 | 9.64 | 4 | 91392 | 18824 | 79634168 |
| Pituitary tumour recurrent | 10.81 | 9.64 | 5 | 91391 | 188 | 79652804 |
| Vertebral artery stenosis | 10.79 | 9.64 | 5 | 91391 | 189 | 79652803 |
| Use of accessory respiratory muscles | 10.76 | 9.64 | 7 | 91389 | 520 | 79652472 |
| Cervical incompetence | 10.76 | 9.64 | 7 | 91389 | 520 | 79652472 |
| Nausea | 10.74 | 9.64 | 948 | 90448 | 956248 | 78696744 |
| Bradyarrhythmia | 10.73 | 9.64 | 18 | 91378 | 4128 | 79648864 |
| Influenza like illness | 10.70 | 9.64 | 44 | 91352 | 71663 | 79581329 |
| Atrioventricular dissociation | 10.70 | 9.64 | 6 | 91390 | 340 | 79652652 |
| Restrictive cardiomyopathy | 10.63 | 9.64 | 9 | 91387 | 999 | 79651993 |
| Carotid artery disease | 10.54 | 9.64 | 13 | 91383 | 2251 | 79650741 |
| Skin tightness | 10.52 | 9.64 | 21 | 91375 | 5501 | 79647491 |
| Fibroadenoma of breast | 10.51 | 9.64 | 6 | 91390 | 352 | 79652640 |
| Abdominal symptom | 10.49 | 9.64 | 8 | 91388 | 765 | 79652227 |
| Parkinsonism | 10.47 | 9.64 | 3 | 91393 | 16581 | 79636411 |
| High density lipoprotein decreased | 10.47 | 9.64 | 19 | 91377 | 4636 | 79648356 |
| Gastric ileus | 10.44 | 9.64 | 3 | 91393 | 27 | 79652965 |
| Acantholysis | 10.44 | 9.64 | 3 | 91393 | 27 | 79652965 |
| Foetal hypokinesia | 10.41 | 9.64 | 6 | 91390 | 358 | 79652634 |
| Peripheral embolism | 10.32 | 9.64 | 12 | 91384 | 1954 | 79651038 |
| Clostridium difficile infection | 10.17 | 9.64 | 21 | 91375 | 42664 | 79610328 |
| Dyslalia | 10.15 | 9.64 | 9 | 91387 | 1063 | 79651929 |
| Pyuria | 10.15 | 9.64 | 13 | 91383 | 2339 | 79650653 |
| Withdrawal hypertension | 10.12 | 9.64 | 6 | 91390 | 378 | 79652614 |
| Vascular resistance systemic decreased | 10.08 | 9.64 | 5 | 91391 | 220 | 79652772 |
| Urticaria pigmentosa | 10.07 | 9.64 | 3 | 91393 | 31 | 79652961 |
| Pancreatitis haemorrhagic | 9.99 | 9.64 | 8 | 91388 | 822 | 79652170 |
| Colon gangrene | 9.98 | 9.64 | 3 | 91393 | 32 | 79652960 |
| Memory impairment | 9.97 | 9.64 | 81 | 91315 | 111653 | 79541339 |
| Intentional product misuse | 9.93 | 9.64 | 66 | 91330 | 95099 | 79557893 |
| Iron binding capacity total decreased | 9.90 | 9.64 | 6 | 91390 | 393 | 79652599 |
| Oliguria | 9.90 | 9.64 | 41 | 91355 | 16268 | 79636724 |
| Hypothermia | 9.87 | 9.64 | 7 | 91389 | 22739 | 79630253 |
| Poikiloderma | 9.85 | 9.64 | 6 | 91390 | 397 | 79652595 |
| Mobility decreased | 9.82 | 9.64 | 91 | 91305 | 122084 | 79530908 |
| Hepatic cytolysis | 9.77 | 9.64 | 10 | 91386 | 27141 | 79625851 |
| Ileal ulcer | 9.74 | 9.64 | 9 | 91387 | 1121 | 79651871 |
| Mydriasis | 9.74 | 9.64 | 4 | 91392 | 17639 | 79635353 |
| Glomerulonephritis membranoproliferative | 9.69 | 9.64 | 7 | 91389 | 616 | 79652376 |
| Spinal cord infarction | 9.69 | 9.64 | 7 | 91389 | 616 | 79652376 |
| Threatened labour | 9.68 | 9.64 | 7 | 91389 | 617 | 79652375 |
| Product dose omission issue | 9.68 | 9.64 | 213 | 91183 | 247324 | 79405668 |
| Hypogonadism | 9.68 | 9.64 | 11 | 91385 | 1749 | 79651243 |
| Cerebellar infarction | 9.66 | 9.64 | 16 | 91380 | 3631 | 79649361 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07FB03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
| ATC | C08CA05 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
| ATC | C08CA55 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
| ATC | C08GA01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics |
| FDA CS | M0006414 | Dihydropyridines |
| FDA MoA | N0000000069 | Calcium Channel Antagonists |
| FDA EPC | N0000175421 | Dihydropyridine Calcium Channel Blocker |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D012102 | Reproductive Control Agents |
| MeSH PA | D015149 | Tocolytic Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:38215 | calcium channel blockers |
| CHEBI has role | CHEBI:66993 | tocolytic drugs |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Prinzmetal angina | indication | 87343002 | |
| Angina pectoris | indication | 194828000 | |
| Premature labor | off-label use | 6383007 | |
| Raynaud's phenomenon | off-label use | 266261006 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Stenosis of intestine | contraindication | 23065003 | |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Left heart failure | contraindication | 85232009 | |
| Cardiogenic shock | contraindication | 89138009 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pyloric obstruction | contraindication | 244815007 | |
| Peripheral edema | contraindication | 271809000 | |
| Continent ileostomy - stoma | contraindication | 311414006 | |
| Non-Q wave myocardial infarction | contraindication | 314207007 | |
| Acute coronary syndrome | contraindication | 394659003 | |
| Porphyria | contraindication | 418470004 | |
| Severe Aortic Valve Stenosis | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.5 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | GATING INHIBITOR | IC50 | 7.70 | IUPHAR | CHEMBL | |||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | Kd | 9.40 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Sodium/nucleoside cotransporter 1 | Transporter | Ki | 5.09 | DRUG MATRIX | |||||
| Adenosine receptor A2a | GPCR | Ki | 4.65 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.30 | WOMBAT-PK | |||||
| Cytochrome P450 3A4 | Enzyme | IC50 | 5.26 | WOMBAT-PK | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.50 | PDSP | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.02 | DRUG MATRIX | |||||
| Adenosine receptor A1 | GPCR | Ki | 5.35 | DRUG MATRIX | |||||
| Adenosine receptor A3 | GPCR | Ki | 5.08 | CHEMBL | |||||
| Glutathione reductase, mitochondrial | Enzyme | Ki | 4.76 | CHEMBL | |||||
| Transthyretin | Secreted | IC50 | 5.66 | WOMBAT-PK | |||||
| ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 4.30 | CHEMBL | |||||
| Glycine receptor subunit alpha-1 | Ion channel | IC50 | 5.48 | CHEMBL | |||||
| Bile salt export pump | Transporter | IC50 | 4.51 | CHEMBL | |||||
| Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 4.67 | WOMBAT-PK | |||||
| Cytochrome P450 1A2 | Enzyme | IC50 | 6.52 | DRUG MATRIX | |||||
| Potassium voltage-gated channel subfamily A member 1 | Ion channel | IC50 | 4.02 | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1S | Ion channel | INHIBITOR | IC50 | 6.30 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily A member 5 | Ion channel | IC50 | 5.21 | CHEMBL | |||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | IC50 | 4.36 | DRUG MATRIX | |||||
| Glycine receptor subunit beta | Ion channel | ANTAGONIST | IC50 | 5.90 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily A member 2 | Ion channel | Kd | 4.70 | WOMBAT-PK | |||||
| Myosin light chain kinase, smooth muscle | Kinase | IC50 | 5.69 | CHEMBL | |||||
| Thromboxane-A synthase | Enzyme | IC50 | 4.73 | DRUG MATRIX | |||||
| C-C chemokine receptor type 2 | GPCR | Ki | 6.07 | DRUG MATRIX | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1F | Ion channel | GATING INHIBITOR | IC50 | 6 | IUPHAR | ||||
| Glycine receptor subunit alpha-3 | Ion channel | ANTAGONIST | IC50 | 4.50 | IUPHAR | ||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.43 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | Ki | 5.40 | CHEMBL | |||||
| Adenosine receptor A2a | GPCR | Ki | 4.74 | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | IC50 | 9 | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | Ki | 8.46 | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | Ki | 8.92 | CHEMBL | |||||
| Cholinesterase | Enzyme | Ki | 5.92 | CHEMBL | |||||
| Indoleamine 2,3-dioxygenase 2 | Enzyme | IC50 | 5.82 | CHEMBL | |||||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | IC50 | 8.59 | CHEMBL | |||||
| Voltage-gated L-type calcium channel | Ion channel | Ki | 8.33 | CHEMBL | |||||
| Indoleamine 2,3-dioxygenase 1 | Enzyme | IC50 | 4.34 | CHEMBL | |||||
| Arachidonate 15-lipoxygenase | Enzyme | IC50 | 4.82 | DRUG MATRIX | |||||
| Potassium voltage-gated channel subfamily A member 7 | Ion channel | BLOCKER | IC50 | 4.90 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily A member 1 | Ion channel | BLOCKER | IC50 | 4 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily A member 2 | Ion channel | BLOCKER | Kd | 4.70 | IUPHAR | ||||
| Potassium channel subfamily K member 2 | Ion channel | IC50 | 5.09 | CHEMBL | |||||
| Bile salt export pump | Transporter | IC50 | 4.34 | CHEMBL | |||||
| Adenosine receptor A1 | GPCR | Ki | 5.54 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018390 | VUID |
| N0000146717 | NUI |
| D00437 | KEGG_DRUG |
| 4018390 | VANDF |
| C0028066 | UMLSCUI |
| CHEBI:7565 | CHEBI |
| C5U | PDB_CHEM_ID |
| CHEMBL193 | ChEMBL_ID |
| DB01115 | DRUGBANK_ID |
| D009543 | MESH_DESCRIPTOR_UI |
| 4485 | PUBCHEM_CID |
| 2514 | IUPHAR_LIGAND_ID |
| 3222 | INN_ID |
| I9ZF7L6G2L | UNII |
| 7417 | RXNORM |
| 2302 | MMSL |
| 5175 | MMSL |
| d00051 | MMSL |
| 000710 | NDDF |
| 017700 | NDDF |
| 387490003 | SNOMEDCT_US |
| 85272000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Procardia XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-2650 | TABLET, FILM COATED, EXTENDED RELEASE | 30 mg | ORAL | NDA | 20 sections |
| Procardia XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-2660 | TABLET, FILM COATED, EXTENDED RELEASE | 60 mg | ORAL | NDA | 20 sections |
| Procardia XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-2670 | TABLET, FILM COATED, EXTENDED RELEASE | 90 mg | ORAL | NDA | 20 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2497 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2530 | CAPSULE, LIQUID FILLED | 20 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7080 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7080 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7081 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7081 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7082 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7082 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7208 | TABLET, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 12 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7229 | CAPSULE | 10 mg | ORAL | ANDA | 19 sections |
| NIFEDIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-319 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | ANDA | 19 sections |
| NIFEDIPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-948 | TABLET, FILM COATED, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 11 sections |
| nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-807 | TABLET, FILM COATED, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 20 sections |
| nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-908 | TABLET, FILM COATED, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 20 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-909 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 14 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-194 | CAPSULE | 10 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-194 | CAPSULE | 10 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-194 | CAPSULE | 10 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-195 | CAPSULE | 20 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-195 | CAPSULE | 20 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-195 | CAPSULE | 20 mg | ORAL | ANDA | 19 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-009 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 11 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-009 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 11 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-009 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 11 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-009 | TABLET, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 11 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-010 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 11 sections |
| Nifedipine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-010 | TABLET, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 11 sections |