niaprazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1908 27367-90-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niaprazine trihydrochloride
  • niaprazine
  • nopron
selective brain catecholamine depletor; RN given refers to parent cpd; structure
  • Molecular weight: 356.45
  • Formula: C20H25FN4O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.47
  • ALOGS: -3.32
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CM16 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Other hypnotics and sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.17 acidic
pKa2 7.92 Basic
pKa3 3.09 Basic
pKa4 0.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07333 KEGG_DRUG
34426-53-4 SECONDARY_CAS_RN
C0068673 UMLSCUI
CHEBI:135505 CHEBI
CHEMBL2105141 ChEMBL_ID
DB13687 DRUGBANK_ID
C021062 MESH_SUPPLEMENTAL_RECORD_UI
71919 PUBCHEM_CID
2817 INN_ID
R2H3YN6E3L UNII
31722 RXNORM
005813 NDDF
713432007 SNOMEDCT_US

Pharmaceutical products:

None