nafamostat Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
proteolytic enzyme inhibitors 1867 81525-10-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nafamostat mesilate
  • nafamostat mesylate
  • FUT-175
  • nafamostat
  • nafamstat
  • nafamostat dihydrochloride
  • nafamostat hydrochloride
  • nafamostat HCl
  • ronastat
inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic; RN given refers to parent cpd
  • Molecular weight: 347.38
  • Formula: C19H17N5O2
  • CLOGP: 2.28
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 5
  • TPSA: 138.07
  • ALOGS: -4.01
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 5.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 81.96 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.84 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D000925 Anticoagulants
MeSH PA D018501 Antirheumatic Agents
MeSH PA D051056 Complement Inactivating Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006401 Hematologic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011480 Protease Inhibitors
MeSH PA D018689 Sensory System Agents
MeSH PA D015842 Serine Proteinase Inhibitors
MeSH PA D014361 Trypsin Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cystic fibrosis indication 190905008 DOID:1485

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.81 Basic
pKa2 10.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Complement C1r subcomponent Enzyme INHIBITOR IC50 6 CHEMBL IUPHAR
Tryptase alpha/beta-1 Enzyme INHIBITOR IC50 10 IUPHAR IUPHAR
Trypsin-1 Enzyme INHIBITOR IC50 7.77 CHEMBL IUPHAR
Prothrombin Enzyme IC50 6.54 CHEMBL
Complement C1s subcomponent Enzyme IC50 6.85 CHEMBL
Kallikrein-1 Enzyme IC50 6.19 CHEMBL
Coagulation factor X Enzyme IC50 4.68 CHEMBL
Acid-sensing ion channel 2 Ion channel BLOCKER IC50 4.20 IUPHAR
Acid-sensing ion channel 1 Ion channel BLOCKER IC50 4.90 IUPHAR
Acid-sensing ion channel 3 Ion channel BLOCKER IC50 5.60 IUPHAR
Serine protease hepsin Enzyme Ki 9.28 CHEMBL
Suppressor of tumorigenicity 14 protein Enzyme Ki 10.70 CHEMBL
Hepatocyte growth factor activator Enzyme Ki 7.60 CHEMBL
Plasminogen Enzyme IC50 6.62 CHEMBL
Cationic trypsin Enzyme IC50 7.77 CHEMBL

External reference:

IDSource
D01670 KEGG_DRUG
1D2T74921W UNII
82956-11-4 SECONDARY_CAS_RN
CHEMBL273264 ChEMBL_ID
CHEMBL1091841 ChEMBL_ID
C032855 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135466 CHEBI
5682 INN_ID
DB12598 DRUGBANK_ID
CHEMBL3989553 ChEMBL_ID
4413 PUBCHEM_CID
4262 IUPHAR_LIGAND_ID

Pharmaceutical products:

None