moracizine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1842 31883-05-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moricizine hydrochloride
  • moracizine
  • moricizine
  • ethmozine
  • moricizine HCl
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
  • Molecular weight: 427.52
  • Formula: C22H25N3O4S
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 71.11
  • ALOGS: -4.10
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.09 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
June 19, 1990 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BG01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Other antiarrhythmics, class I and III
FDA EPC N0000175426 Antiarrhythmic
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers
CHEBI has role CHEBI:38070 antiarrhythmic agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ventricular arrhythmia indication 44103008

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.75 acidic
pKa2 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL

External reference:

IDSource
4019551 VUID
N0000179669 NUI
D02087 KEGG_DRUG
29560-58-5 SECONDARY_CAS_RN
4019551 VANDF
4019845 VANDF
C0591466 UMLSCUI
CHEBI:60937 CHEBI
CHEMBL1075 ChEMBL_ID
CHEMBL1200334 ChEMBL_ID
D016293 MESH_DESCRIPTOR_UI
DB00680 DRUGBANK_ID
34632 PUBCHEM_CID
7244 IUPHAR_LIGAND_ID
2998 INN_ID
2GT1D0TMX1 UNII
151721 RXNORM
1620 MMSL
5135 MMSL
d00307 MMSL
003553 NDDF
004488 NDDF
108489008 SNOMEDCT_US
350598002 SNOMEDCT_US
373726009 SNOMEDCT_US

Pharmaceutical products:

None