moperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives	1837	1050-79-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

moperone hydrochloride
moperone
luvatren
luvatrena
meperon
methylperidol
moperone HCl

Molecular weight: 355.45
Formula: C22H26FNO2
CLOGP: 3.63
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 40.54
ALOGS: -4.54
ROTB: 6

Drug dosage:

Dose	Unit	Route
20	mg	O
20	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AD04	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.36	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	9		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	9.50		PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	8.13		PDSP

External reference:

ID	Source
D01105	KEGG_DRUG
3871-82-7	SECONDARY_CAS_RN
C0066787	UMLSCUI
CHEBI:31865	CHEBI
CHEMBL2104700	ChEMBL_ID
DB13554	DRUGBANK_ID
C005209	MESH_SUPPLEMENTAL_RECORD_UI
4249	PUBCHEM_CID
1589	INN_ID
OU730881W5	UNII
005973	NDDF
005974	NDDF

Pharmaceutical products:

None