montelukast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
leukotriene receptor antagonists 1836 158966-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • montelukast
  • montelukast sodium
  • singulair
Montelukast is an orally active compound that binds with high affinity and selectivity to the CysLT1 receptor (in preference to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor). Montelukast inhibits physiologic actions of cysteinyl leukotriene LTD4 at the CysLT1 receptor without any agonist activity.
  • Molecular weight: 586.19
  • Formula: C35H36ClNO3S
  • CLOGP: 8.33
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 2
  • TPSA: 70.42
  • ALOGS: -7.85
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.28 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 62 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.68 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1998 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 4137.86 9.91 2990 171281 86347 50344506
Wheezing 1812.27 9.91 1586 172685 60461 50370392
Eosinophilic granulomatosis with polyangiitis 1265.55 9.91 406 173865 1549 50429304
Obstructive airways disorder 770.52 9.91 545 173726 15107 50415746
Dyspnoea 676.81 9.91 3682 170589 543926 49886927
Cough 670.61 9.91 2087 172184 239177 50191676
Sputum discoloured 594.41 9.91 438 173833 12957 50417896
Productive cough 518.14 9.91 765 173506 51929 50378924
Sleep disorder due to a general medical condition 514.05 9.91 319 173952 7052 50423801
Forced expiratory volume decreased 491.87 9.91 259 174012 4135 50426718
Chest discomfort 449.70 9.91 989 173282 91733 50339120
Pemphigus 391.75 9.91 4 174267 120162 50310691
Full blood count abnormal 388.03 9.91 440 173831 22948 50407905
Toxicity to various agents 337.18 9.91 155 174116 212344 50218509
Synovitis 322.76 9.91 28 174243 123837 50307016
Urticaria 317.63 9.91 1075 173196 128486 50302367
Hand deformity 315.08 9.91 6 174265 100193 50330660
Sinusitis 291.10 9.91 1261 173010 169297 50261556
Bronchitis 290.24 9.91 903 173368 103256 50327597
Systemic lupus erythematosus 283.27 9.91 68 174203 140554 50290299
Treatment failure 268.66 9.91 71 174200 137566 50293287
Nasal congestion 267.99 9.91 563 173708 50557 50380296
Glossodynia 261.91 9.91 42 174229 115527 50315326
Upper respiratory tract infection 250.98 9.91 640 173631 65258 50365595
Food allergy 245.12 9.91 212 174059 7925 50422928
Contraindicated product administered 241.89 9.91 105 174166 148853 50282000
Chronic obstructive pulmonary disease 237.69 9.91 551 173720 52884 50377969
Drug intolerance 235.83 9.91 244 174027 218860 50211993
Arthropathy 221.18 9.91 135 174136 157771 50273082
Blood immunoglobulin E increased 216.69 9.91 122 174149 2237 50428616
Asthmatic crisis 211.23 9.91 106 174165 1522 50429331
Joint swelling 210.05 9.91 325 173946 244961 50185892
Nasal polyps 205.04 9.91 121 174150 2433 50428420
Pericarditis 196.46 9.91 21 174250 78668 50352185
Anaphylactic reaction 193.49 9.91 513 173758 53542 50377311
Rhinitis allergic 189.88 9.91 174 174097 7026 50423827
Nightmare 188.31 9.91 254 174017 15832 50415021
Temperature regulation disorder 186.99 9.91 138 174133 4089 50426764
Middle insomnia 185.90 9.91 199 174072 9722 50421131
Neutropenia 181.44 9.91 146 174125 147819 50283034
Pneumonia 180.81 9.91 2044 172227 376357 50054496
Infusion related reaction 173.29 9.91 197 174074 169360 50261493
Acute kidney injury 168.97 9.91 331 173940 227727 50203126
Sleep apnoea syndrome 165.58 9.91 296 173975 23572 50407281
Eosinophil count increased 165.24 9.91 177 174094 8653 50422200
Completed suicide 164.39 9.91 128 174143 131761 50299092
Alopecia 161.32 9.91 380 173891 244667 50186186
Influenza 160.24 9.91 672 173599 88866 50341987
Therapeutic product effect incomplete 160.02 9.91 682 173589 90833 50340020
Wound 155.84 9.91 85 174186 105709 50325144
Seasonal allergy 155.69 9.91 221 174050 14455 50416398
Product quality issue 154.91 9.91 334 173937 30524 50400329
Breath sounds abnormal 152.57 9.91 160 174111 7632 50423221
Off label use 152.10 9.91 984 173287 473442 49957411
Dyspnoea exertional 149.87 9.91 452 173819 50781 50380072
Gastrooesophageal reflux disease 148.95 9.91 589 173682 75839 50355014
Maternal exposure during pregnancy 148.18 9.91 200 174071 159578 50271275
Therapeutic product effect decreased 146.83 9.91 151 174120 135899 50294954
Infective pulmonary exacerbation of cystic fibrosis 143.55 9.91 156 174115 7753 50423100
Coeliac disease 143.34 9.91 163 174108 8522 50422331
Drug interaction 133.38 9.91 307 173964 199314 50231539
Malignant neoplasm progression 133.13 9.91 35 174236 68089 50362764
Pancytopenia 132.01 9.91 62 174209 83968 50346885
Thrombocytopenia 130.77 9.91 148 174123 127525 50303328
Anaemia 130.28 9.91 440 173831 252016 50178837
Sleep terror 130.25 9.91 59 174212 664 50430189
Drug abuse 128.45 9.91 25 174246 59821 50371032
Helicobacter infection 124.72 9.91 13 174258 49689 50381164
Death 121.61 9.91 642 173629 324737 50106116
Febrile neutropenia 117.65 9.91 98 174173 97569 50333284
Rhinitis 117.46 9.91 144 174127 8157 50422696
Bronchospasm 114.49 9.91 193 174078 14661 50416192
Upper-airway cough syndrome 114.06 9.91 144 174127 8406 50422447
Muscle injury 113.59 9.91 3 174268 37108 50393745
Abdominal discomfort 113.26 9.91 413 173858 231228 50199625
Rhinorrhoea 113.24 9.91 413 173858 51170 50379683
Polycystic ovaries 111.91 9.91 82 174189 2402 50428451
Product dose omission issue 111.29 9.91 1043 173228 182795 50248058
Secretion discharge 110.65 9.91 152 174119 9639 50421214
Folliculitis 110.44 9.91 6 174265 39219 50391634
Anxiety 108.68 9.91 1010 173261 176596 50254257
General physical health deterioration 108.65 9.91 203 174068 142231 50288622
Headache 108.19 9.91 2390 171881 504145 49926708
Stomatitis 106.49 9.91 115 174156 101229 50329624
Suicidal ideation 106.41 9.91 425 173846 54960 50375893
Drug ineffective 106.16 9.91 2089 172182 817244 49613609
Aggression 104.19 9.91 227 174044 20889 50409964
Impaired healing 102.85 9.91 56 174215 69730 50361123
Peak expiratory flow rate decreased 102.83 9.91 47 174224 541 50430312
Dysphonia 102.53 9.91 331 173940 38561 50392292
Respiratory tract congestion 102.23 9.91 179 174092 14020 50416833
Loss of personal independence in daily activities 100.78 9.91 493 173778 69557 50361296
Respiratory tract infection 96 9.91 285 173986 31732 50399121
Perfume sensitivity 95.15 9.91 45 174226 563 50430290
Hyponatraemia 94.61 9.91 115 174156 96024 50334829
Sputum increased 94.14 9.91 66 174205 1801 50429052
Eczema 92.15 9.91 226 174045 22476 50408377
Rheumatoid arthritis 91.98 9.91 372 173899 202178 50228675
Total lung capacity increased 90.41 9.91 46 174225 681 50430172
Lung hyperinflation 89.83 9.91 53 174218 1065 50429788
Sensitisation 89.40 9.91 60 174211 1522 50429331
Immunodeficiency 87.99 9.91 172 174099 14656 50416197
Heart rate increased 87.46 9.91 509 173762 76741 50354112
Sinus disorder 87.20 9.91 195 174076 18263 50412590
Disease progression 84.84 9.91 124 174147 95742 50335111
Status asthmaticus 84.52 9.91 46 174225 787 50430066
Impaired quality of life 83.98 9.91 104 174167 5952 50424901
Oropharyngeal pain 83.82 9.91 506 173765 77295 50353558
Reversible airways obstruction 83.66 9.91 49 174222 971 50429882
Respiratory rate increased 82.58 9.91 144 174127 11241 50419612
Leukopenia 82.25 9.91 67 174204 67461 50363392
Blood test abnormal 79.30 9.91 141 174130 11178 50419675
Multiple organ dysfunction syndrome 79.26 9.91 37 174234 50300 50380553
Vital capacity decreased 78.60 9.91 46 174225 910 50429943
Swelling 76.80 9.91 393 173878 200479 50230374
Pruritus 76.70 9.91 1387 172884 282181 50148672
Forced vital capacity decreased 76.64 9.91 45 174226 896 50429957
Chronic sinusitis 76.48 9.91 100 174171 6045 50424808
Dermatitis atopic 76.29 9.91 77 174194 3509 50427344
Eosinophilia 76.04 9.91 186 174085 18466 50412387
Hypotension 75.89 9.91 487 173784 234982 50195871
Sensitivity to weather change 75.22 9.91 98 174173 5903 50424950
Rales 74.72 9.91 128 174143 9850 50421003
Blood pressure systolic increased 74.59 9.91 280 173991 35169 50395684
Throat clearing 73.92 9.91 48 174223 1150 50429703
Mucosal inflammation 72.25 9.91 24 174247 40118 50390735
Renal impairment 71.83 9.91 93 174178 75568 50355285
Abnormal behaviour 70.74 9.91 187 174084 19471 50411382
Throat irritation 69.67 9.91 246 174025 29993 50400860
Respiratory symptom 68.90 9.91 61 174210 2353 50428500
Bronchial secretion retention 68.29 9.91 50 174221 1463 50429390
Dust allergy 68.27 9.91 35 174236 527 50430326
Respiration abnormal 68.17 9.91 86 174185 5016 50425837
C-reactive protein abnormal 67.93 9.91 8 174263 27801 50403052
Intentional overdose 67.81 9.91 69 174202 62435 50368418
Musculoskeletal stiffness 67.49 9.91 222 174049 128259 50302594
Discomfort 66.56 9.91 174 174097 108206 50322647
C-reactive protein increased 65.93 9.91 79 174192 66395 50364458
Sneezing 65.92 9.91 148 174123 13896 50416957
Sleep disorder due to general medical condition, insomnia type 63.67 9.91 15 174256 31432 50399421
Poor quality device used 63.53 9.91 52 174219 1799 50429054
Bradycardia 63.44 9.91 77 174194 64349 50366504
Ejection fraction 61.86 9.91 43 174228 1157 50429696
Coma 61.46 9.91 63 174208 56816 50374037
Rhonchi 61.31 9.91 56 174215 2251 50428602
Septic shock 61.02 9.91 64 174207 57111 50373742
Sinus congestion 60.91 9.91 143 174128 13828 50417025
Emphysema 60.80 9.91 111 174160 8982 50421871
Bursitis 60.71 9.91 191 174080 21944 50408909
Bone marrow failure 60.42 9.91 11 174260 27613 50403240
Toxic epidermal necrolysis 59.76 9.91 3 174268 20989 50409864
Abnormal dreams 59.60 9.91 112 174159 9265 50421588
Crying 59.56 9.91 180 174091 20236 50410617
Illness 59.45 9.91 203 174068 24337 50406516
Metabolic acidosis 58.90 9.91 30 174241 38795 50392058
Malaise 58.59 9.91 1541 172730 333991 50096862
Hyperkalaemia 58.20 9.91 48 174223 48041 50382812
Throat tightness 57.28 9.91 180 174091 20667 50410186
Blister 57.27 9.91 131 174140 85287 50345566
Angioedema 56.94 9.91 269 174002 37407 50393446
Pulmonary function test decreased 56.61 9.91 64 174207 3324 50427529
Nasopharyngitis 56.51 9.91 956 173315 191971 50238882
Cystic fibrosis 56.41 9.91 59 174212 2805 50428048
Rash erythematous 55.00 9.91 252 174019 34600 50396253
Gastrointestinal disorder 54.73 9.91 156 174115 94300 50336553
Confusional state 54.66 9.91 395 173876 185533 50245320
Bronchial disorder 54.41 9.91 39 174232 1103 50429750
Hypokalaemia 54.23 9.91 141 174130 87851 50343002
Depressed level of consciousness 53.40 9.91 60 174211 51893 50378960
Eye pruritus 53.24 9.91 127 174144 12407 50418446
Respiratory disorder 52.59 9.91 230 174041 30957 50399896
Factor V Leiden mutation 52.50 9.91 21 174250 169 50430684
Haemoglobin decreased 51.99 9.91 243 174028 126973 50303880
Sinusitis fungal 51.92 9.91 40 174231 1266 50429587
Hepatic enzyme increased 51.78 9.91 270 174001 137110 50293743
Asthma exercise induced 51.24 9.91 23 174248 253 50430600
Multiple allergies 51.22 9.91 99 174172 8364 50422489
Blood pressure increased 51.10 9.91 691 173580 132441 50298412
Insomnia 50.65 9.91 865 173406 174000 50256853
Migraine 50.52 9.91 437 173834 74843 50356010
Bronchial neoplasm 49.82 9.91 26 174245 407 50430446
Hyper IgE syndrome 49.76 9.91 26 174245 408 50430445
Smoke sensitivity 49.46 9.91 24 174247 319 50430534
Diarrhoea 49.19 9.91 1599 172672 586877 49843976
Intentional product use issue 49.14 9.91 121 174150 76797 50354056
Cardiac failure 49.07 9.91 119 174152 75921 50354932
Aspirin-exacerbated respiratory disease 49.04 9.91 33 174238 841 50430012
Restrictive pulmonary disease 48.86 9.91 40 174231 1384 50429469
Bronchial obstruction 48.01 9.91 38 174233 1252 50429601
Asthma-chronic obstructive pulmonary disease overlap syndrome 47.55 9.91 26 174245 449 50430404
Infusion site pruritus 47.34 9.91 63 174208 3874 50426979
Nasal discharge discolouration 46.72 9.91 40 174231 1474 50429379
Nasal turbinate hypertrophy 46.72 9.91 29 174242 641 50430212
Mood altered 46.46 9.91 122 174149 12651 50418202
Hypoventilation 46.01 9.91 62 174209 3859 50426994
Nasal oedema 45.76 9.91 31 174240 799 50430054
Depression 45.65 9.91 812 173459 164611 50266242
Bronchial haemorrhage 45.35 9.91 26 174245 494 50430359
Salpingo-oophorectomy unilateral 44.40 9.91 26 174245 515 50430338
Metastases to bone 44.39 9.91 5 174266 17990 50412863
Idiopathic intracranial hypertension 43.80 9.91 47 174224 2302 50428551
Infusion site swelling 43.50 9.91 84 174187 7092 50423761
Pulmonary function test abnormal 43.26 9.91 36 174235 1275 50429578
Infusion site erythema 43.26 9.91 94 174177 8633 50422220
Ascites 43.14 9.91 36 174235 35825 50395028
Red blood cell sedimentation rate increased 42.76 9.91 24 174247 29392 50401461
Irritable bowel syndrome 42.19 9.91 70 174201 51371 50379482
Pulmonary mass 42.08 9.91 151 174120 18554 50412299
Platelet count decreased 41.98 9.91 191 174080 100535 50330318
Aphonia 41.66 9.91 91 174180 8387 50422466
Feeling abnormal 41.64 9.91 635 173636 124857 50305996
Hepatotoxicity 41.35 9.91 21 174250 27205 50403648
Mood swings 41.33 9.91 135 174136 15819 50415034
Sepsis 40.71 9.91 279 173992 132646 50298207
Neoplasm progression 40.67 9.91 25 174246 29132 50401721
Prolonged expiration 39.92 9.91 27 174244 694 50430159
Nasal obstruction 39.59 9.91 31 174240 1005 50429848
Cholestasis 39.48 9.91 19 174252 25382 50405471
Neurotoxicity 39.28 9.91 3 174268 14737 50416116
Alanine aminotransferase increased 38.97 9.91 164 174107 88195 50342658
Anger 38.95 9.91 106 174165 11227 50419626
Scratch 38.94 9.91 65 174206 4897 50425956
Cholecystitis chronic 37.91 9.91 95 174176 9574 50421279
Frustration tolerance decreased 37.60 9.91 69 174202 5605 50425248
Cardio-respiratory arrest 37.47 9.91 81 174190 53811 50377042
Chronic spontaneous urticaria 37.35 9.91 23 174248 501 50430352
Humidity intolerance 37.30 9.91 19 174252 282 50430571
Bronchiectasis 37.18 9.91 98 174173 10185 50420668
Poor quality sleep 37.12 9.91 134 174137 16512 50414341
Hereditary angioedema 37.11 9.91 67 174204 5375 50425478
Dehydration 36.95 9.91 341 173930 152108 50278745
Haemoptysis 36.77 9.91 180 174091 25393 50405460
Lipohypertrophy 36.45 9.91 24 174247 589 50430264
Viral infection 36.16 9.91 201 174070 29785 50401068
Increased bronchial secretion 35.93 9.91 35 174236 1527 50429326
Bronchopulmonary aspergillosis allergic 35.81 9.91 31 174240 1160 50429693
Fluid retention 35.55 9.91 297 173974 50352 50380501
Decreased appetite 35.43 9.91 483 173788 200440 50230413
Hepatocellular injury 35.15 9.91 23 174248 25924 50404929
Eosinophil count abnormal 34.90 9.91 21 174250 438 50430415
Live birth 34.89 9.91 7 174264 16401 50414452
Body tinea 34.85 9.91 32 174239 1295 50429558
Hip arthroplasty 34.85 9.91 32 174239 30397 50400456
Metastases to liver 34.50 9.91 13 174258 20091 50410762
Palmar-plantar erythrodysaesthesia syndrome 34.48 9.91 13 174258 20085 50410768
Allergy to animal 33.99 9.91 26 174245 814 50430039
Vocal cord dysfunction 33.91 9.91 19 174252 345 50430508
Product use issue 33.83 9.91 340 173931 149135 50281718
Cytomegalovirus infection 33.64 9.91 10 174261 17952 50412901
Encephalopathy 33.49 9.91 40 174231 33671 50397182
Agranulocytosis 33.33 9.91 16 174255 21405 50409448
White blood cell count decreased 33.30 9.91 250 174021 116472 50314381
Gastrointestinal haemorrhage 33.01 9.91 135 174136 73186 50357667
Atopy 32.88 9.91 16 174255 214 50430639
Lactic acidosis 32.69 9.91 40 174231 33315 50397538
Mastocytosis 32.53 9.91 21 174250 498 50430355
Biliary dyskinesia 32.52 9.91 42 174229 2508 50428345
Mobility decreased 32.48 9.91 153 174118 79795 50351058
Arthralgia 32.41 9.91 1210 173061 437492 49993361
Skin plaque 32.33 9.91 69 174202 6259 50424594
Oxygen saturation decreased 32.24 9.91 390 173881 72858 50357995
Neutrophil count decreased 32.14 9.91 69 174202 45957 50384896
FEV1/FVC ratio decreased 32.07 9.91 11 174260 54 50430799
Inhibitory drug interaction 32.02 9.91 39 174232 2194 50428659
Cardiac arrest 31.73 9.91 164 174107 83487 50347366
Total lung capacity decreased 31.72 9.91 30 174241 1261 50429592
Endometrial ablation 31.22 9.91 25 174246 838 50430015
Knee arthroplasty 31.08 9.91 47 174224 35799 50395054
Increased viscosity of bronchial secretion 30.97 9.91 16 174255 245 50430608
Acute myeloid leukaemia 30.89 9.91 7 174264 15067 50415786
Renal failure 30.61 9.91 228 174043 106405 50324448
Anosmia 30.19 9.91 51 174220 3880 50426973
Skin ulcer 29.95 9.91 47 174224 35271 50395582
Nephrectomy 29.80 9.91 24 174247 811 50430042
Blood creatinine increased 29.63 9.91 148 174123 76012 50354841
Swelling face 29.57 9.91 294 173977 52301 50378552
Aspartate aminotransferase increased 29.53 9.91 153 174118 77845 50353008
Sputum culture positive 29.42 9.91 30 174241 1384 50429469
Irritability 29.40 9.91 183 174088 28243 50402610
Bronchitis chronic 29.38 9.91 50 174221 3827 50427026
Pharyngeal oedema 29.38 9.91 106 174165 13059 50417794
Infusion site pain 28.91 9.91 101 174170 12245 50418608
Inflammation 28.73 9.91 100 174171 56812 50374041
Eosinophilic pneumonia 28.52 9.91 34 174237 1870 50428983
Interstitial lung disease 28.51 9.91 91 174180 53085 50377768
Colitis 28.39 9.91 56 174215 38473 50392380
Embolism venous 28.23 9.91 39 174232 2486 50428367
Circulatory collapse 28.10 9.91 17 174254 19983 50410870
Disseminated intravascular coagulation 27.90 9.91 12 174259 17123 50413730
Osteonecrosis of jaw 27.86 9.91 43 174228 32483 50398370
Creatinine renal clearance decreased 27.62 9.91 4 174267 11877 50418976
Inappropriate schedule of product administration 27.61 9.91 373 173898 71458 50359395
Ear infection 27.37 9.91 168 174103 25802 50405051
Liver injury 27.34 9.91 27 174244 24779 50406074
Neurosensory hypoacusis 27.18 9.91 14 174257 213 50430640
Bone erosion 27.02 9.91 4 174267 11683 50419170
Swollen tongue 26.96 9.91 180 174091 28450 50402403
Respiratory gas exchange disorder 26.75 9.91 16 174255 330 50430523
Liver disorder 26.66 9.91 55 174216 37167 50393686
Heart sounds 26.60 9.91 20 174251 610 50430243
Rash 26.50 9.91 1234 173037 436237 49994616
Glucose tolerance impaired 26.37 9.91 56 174215 5062 50425791
Lymphocyte count decreased 26.36 9.91 31 174240 26276 50404577
Neutropenic sepsis 26.27 9.91 8 174263 14139 50416714
Paraesthesia oral 26.09 9.91 97 174174 12124 50418729
Infection susceptibility increased 26.07 9.91 38 174233 2546 50428307
Rash maculo-papular 26.05 9.91 32 174239 26609 50404244
Blood bilirubin increased 25.89 9.91 44 174227 31994 50398859
Vomiting 25.89 9.91 1310 172961 459448 49971405
Mast cell activation syndrome 25.88 9.91 16 174255 351 50430502
Increased upper airway secretion 25.77 9.91 42 174229 3102 50427751
Condition aggravated 25.70 9.91 803 173468 296255 50134598
Urticaria chronic 25.68 9.91 18 174253 491 50430362
Anuria 25.65 9.91 4 174267 11240 50419613
Pneumonia aspiration 25.60 9.91 42 174229 30962 50399891
Rhabdomyolysis 25.23 9.91 61 174210 38966 50391887
Spirometry abnormal 25.11 9.91 13 174258 200 50430653
Erythema 25.05 9.91 671 173600 145743 50285110
Occupational asthma 24.91 9.91 11 174260 116 50430737
Pulmonary pain 24.75 9.91 35 174236 2280 50428573
Infusion site extravasation 24.73 9.91 66 174205 6910 50423943
Infection 24.62 9.91 433 173838 172521 50258332
Weight increased 24.40 9.91 887 173384 201004 50229849
Hypocalcaemia 24.38 9.91 34 174237 26782 50404071
Psoriasis 24.38 9.91 353 173918 68647 50362206
Hypersensitivity 24.26 9.91 938 173333 214223 50216630
Progressive multifocal leukoencephalopathy 24.13 9.91 5 174266 11452 50419401
Nocturnal fear 23.91 9.91 6 174265 6 50430847
Gamma-glutamyltransferase increased 23.65 9.91 41 174230 29582 50401271
Drug level increased 23.60 9.91 19 174252 19249 50411604
Lower respiratory tract congestion 23.60 9.91 32 174239 2004 50428849
Therapy non-responder 23.56 9.91 93 174178 50929 50379924
Hypomagnesaemia 23.51 9.91 27 174244 23129 50407724
Blood creatine phosphokinase increased 23.41 9.91 34 174237 26333 50404520
Pain 23.34 9.91 1698 172573 577205 49853648
Exposure to allergen 23.33 9.91 12 174259 182 50430671
Paranasal sinus discomfort 23.28 9.91 39 174232 2947 50427906
Acute respiratory distress syndrome 23.21 9.91 23 174248 21076 50409777
Mononeuropathy multiplex 23.20 9.91 13 174258 236 50430617
Stress 23.05 9.91 285 173986 53508 50377345
Palpitations 22.96 9.91 455 173816 94051 50336802
Lung opacity 22.85 9.91 31 174240 1942 50428911
Chest pain 22.83 9.91 783 173488 176099 50254754
Lung diffusion test decreased 22.79 9.91 18 174253 591 50430262
Separation anxiety disorder 22.62 9.91 7 174264 23 50430830
Affective disorder 22.55 9.91 53 174218 5128 50425725
Product substitution issue 22.44 9.91 102 174169 13955 50416898
Burning sensation 22.24 9.91 247 174024 45199 50385654
Ankle fracture 22.13 9.91 110 174161 15612 50415241
Infusion site urticaria 22.08 9.91 22 174249 987 50429866
Hepatic failure 22.04 9.91 49 174222 32234 50398619
Allergy test positive 22.03 9.91 15 174256 390 50430463
Infusion site haemorrhage 21.79 9.91 38 174233 2966 50427887
Nasal inflammation 21.69 9.91 15 174256 400 50430453
Anaphylactic shock 21.63 9.91 131 174140 20024 50410829
Orthostatic hypotension 21.59 9.91 43 174228 29438 50401415
Eye paraesthesia 21.59 9.91 8 174263 51 50430802
Upper airway obstruction 21.58 9.91 17 174254 556 50430297
Premature delivery 21.52 9.91 30 174241 23633 50407220
Influenza like illness 21.51 9.91 297 173974 57162 50373691
Drug tolerance decreased 21.49 9.91 3 174268 9157 50421696
Pharyngeal swelling 21.30 9.91 48 174223 4518 50426335
Lip swelling 21.22 9.91 152 174119 24584 50406269
Neuroleptic malignant syndrome 21.21 9.91 6 174265 11124 50419729
Carpal tunnel syndrome 20.88 9.91 114 174157 16779 50414074
Hypercapnia 20.87 9.91 48 174223 4579 50426274
Delirium 20.72 9.91 65 174206 38127 50392726
Infusion site bruising 20.66 9.91 32 174239 2263 50428590
Educational problem 20.52 9.91 14 174257 365 50430488
Product container issue 20.51 9.91 25 174246 1407 50429446
Expiratory reserve volume decreased 20.47 9.91 7 174264 34 50430819
Hepatic function abnormal 20.41 9.91 52 174219 32629 50398224
Respiratory tract inflammation 20.30 9.91 16 174255 524 50430329
Hyperhidrosis 20.22 9.91 426 173845 89000 50341853
Ear discomfort 20.18 9.91 60 174211 6684 50424169
Dyspnoea at rest 20.07 9.91 41 174230 3606 50427247
Cognitive disorder 20.01 9.91 81 174190 44042 50386811
Eosinophilic oesophagitis 19.83 9.91 12 174259 253 50430600
Obstruction 19.80 9.91 30 174241 2081 50428772
Hypoglycaemia 19.78 9.91 106 174165 53475 50377378
Atrial fibrillation 19.61 9.91 240 174031 101505 50329348
Hypoalbuminaemia 19.38 9.91 5 174266 9855 50420998
Product use in unapproved indication 19.29 9.91 529 173742 115290 50315563
Gluten sensitivity 19.19 9.91 15 174256 485 50430368
Adrenal suppression 19.06 9.91 19 174252 853 50430000
Lung disorder 19.04 9.91 237 174034 44562 50386291
Cerebral infarction 19.04 9.91 28 174243 21576 50409277
Serotonin syndrome 19.01 9.91 35 174236 24678 50406175
Choking sensation 19 9.91 37 174234 3143 50427710
Pleural effusion 18.95 9.91 184 174087 81270 50349583
Somnambulism 18.91 9.91 48 174223 4876 50425977
Mite allergy 18.85 9.91 15 174256 498 50430355
Inappropriate antidiuretic hormone secretion 18.70 9.91 11 174260 13132 50417721
Airway peak pressure increased 18.65 9.91 12 174259 283 50430570
Airway remodelling 18.58 9.91 7 174264 47 50430806
Bronchial wall thickening 18.46 9.91 19 174252 886 50429967
Administration site erythema 18.30 9.91 15 174256 520 50430333
Metastases to central nervous system 18.21 9.91 8 174263 11274 50419579
Tuberculosis 18.19 9.91 6 174265 10077 50420776
Torsade de pointes 18.17 9.91 9 174262 11826 50419027
Sedation 18.13 9.91 50 174221 30560 50400293
Decubitus ulcer 18.09 9.91 5 174266 9413 50421440
Pharyngitis streptococcal 18.05 9.91 69 174202 8739 50422114
Thinking abnormal 18.03 9.91 73 174198 9494 50421359
Lactose intolerance 17.98 9.91 32 174239 2538 50428315
Paranoia 17.97 9.91 77 174194 10271 50420582
Appetite disorder 17.92 9.91 54 174217 6060 50424793
CFTR gene mutation 17.90 9.91 8 174263 87 50430766
Body temperature decreased 17.87 9.91 107 174164 16288 50414565
Tenosynovitis 17.85 9.91 7 174264 10558 50420295
COVID-19 17.80 9.91 242 174029 46420 50384433
Weight decreased 17.80 9.91 932 173339 220313 50210540
Pneumothorax spontaneous 17.58 9.91 16 174255 640 50430213
Stevens-Johnson syndrome 17.46 9.91 30 174241 21722 50409131
Acute hepatic failure 17.35 9.91 17 174254 15660 50415193
Pneumocystis jirovecii pneumonia 17.29 9.91 15 174256 14648 50416205
Acute sinusitis 17.25 9.91 38 174233 3522 50427331
Pneumococcal infection 17.22 9.91 13 174258 399 50430454
Hysterectomy 17.16 9.91 63 174208 7827 50423026
Hypercalcaemia 17.16 9.91 34 174237 23318 50407535
Blood alkaline phosphatase increased 16.94 9.91 69 174202 37457 50393396
Altered state of consciousness 16.88 9.91 31 174240 21879 50408974
Drug eruption 16.80 9.91 35 174236 23571 50407282
Cortisol decreased 16.68 9.91 19 174252 995 50429858
Pre-existing condition improved 16.57 9.91 58 174213 7039 50423814
Hiatus hernia 16.48 9.91 114 174157 18230 50412623
Mycotic allergy 16.36 9.91 17 174254 802 50430051
Conjunctivitis allergic 16.35 9.91 16 174255 702 50430151
Bronchial irritation 16.25 9.91 5 174266 16 50430837
Pulmonary thrombosis 16.22 9.91 60 174211 7481 50423372
Left ventricular dysfunction 16.11 9.91 8 174263 10498 50420355
Lymphopenia 16.09 9.91 18 174253 15603 50415250
Vocal cord disorder 16.09 9.91 21 174250 1267 50429586
Ulcer 16.09 9.91 28 174243 20172 50410681
Bronchial hyperreactivity 15.95 9.91 22 174249 1400 50429453
Myalgia 15.95 9.91 550 173721 123769 50307084
Product contamination physical 15.92 9.91 7 174264 73 50430780
Neurogenic shock 15.92 9.91 11 174260 293 50430560
Nephropathy toxic 15.92 9.91 4 174267 8025 50422828
Diabetic ketoacidosis 15.91 9.91 23 174248 17849 50413004
Nodular vasculitis 15.81 9.91 5 174266 18 50430835
Peritonitis 15.78 9.91 18 174253 15468 50415385
Ischaemic stroke 15.76 9.91 19 174252 15929 50414924
Bacteraemia 15.57 9.91 16 174255 14417 50416436
Blood pressure fluctuation 15.47 9.91 67 174204 35756 50395097
Sinus polyp 15.47 9.91 11 174260 307 50430546
Tic 15.45 9.91 20 174251 1197 50429656
Panniculitis 15.45 9.91 5 174266 8498 50422355
Drug resistance 15.42 9.91 26 174245 18963 50411890
Muscle spasticity 15.41 9.91 22 174249 17162 50413691
Peripheral swelling 15.37 9.91 567 173704 205369 50225484
Transaminases increased 15.35 9.91 47 174224 27777 50403076
Allergic sinusitis 15.28 9.91 14 174257 565 50430288
Quality of life decreased 15.24 9.91 52 174219 6231 50424622
Liver function test abnormal 15.13 9.91 90 174181 44249 50386604
Oesophageal dilatation 15.02 9.91 11 174260 322 50430531
Candida infection 14.97 9.91 135 174136 23388 50407465
Incorrect dose administered 14.91 9.91 242 174029 48172 50382681
Cardiac murmur 14.86 9.91 75 174196 10709 50420144
Nervousness 14.79 9.91 153 174118 27498 50403355
Miller Fisher syndrome 14.77 9.91 7 174264 88 50430765
Anticholinergic syndrome 14.74 9.91 24 174247 1771 50429082
Muscle tension dysphonia 14.68 9.91 4 174267 7 50430846
Rhinitis perennial 14.67 9.91 5 174266 24 50430829
Ear pruritus 14.62 9.91 29 174242 2497 50428356
Laryngitis fungal 14.59 9.91 8 174263 139 50430714
Foetal exposure during pregnancy 14.54 9.91 47 174224 27312 50403541
Cytopenia 14.52 9.91 6 174265 8769 50422084
International normalised ratio increased 14.51 9.91 88 174183 43064 50387789
Ejection fraction decreased 14.45 9.91 26 174245 18494 50412359
Sarcoidosis 14.41 9.91 44 174227 4973 50425880
Osteomyelitis 14.40 9.91 35 174236 22318 50408535
Acute myocardial infarction 14.39 9.91 52 174219 29221 50401632
Female genital tract fistula 14.35 9.91 36 174235 3630 50427223
Respiratory tract irritation 14.35 9.91 12 174259 428 50430425
Intentional product misuse 14.34 9.91 98 174173 46636 50384217
Drug reaction with eosinophilia and systemic symptoms 14.30 9.91 50 174221 28374 50402479
Pulmonary eosinophilia 14.30 9.91 9 174262 204 50430649
Oesophagogastroduodenoscopy 14.30 9.91 7 174264 95 50430758
Lip discolouration 14.24 9.91 13 174258 522 50430331
Pregnancy 14.24 9.91 53 174218 29524 50401329
Skin necrosis 14.23 9.91 10 174261 10857 50419996
Oropharyngeal discomfort 14.18 9.91 37 174234 3821 50427032
Ejection fraction abnormal 14.15 9.91 16 174255 831 50430022
Sleep study abnormal 14.02 9.91 3 174268 0 50430853
Glomus tumour 14.02 9.91 3 174268 0 50430853
Unresponsive to stimuli 14.00 9.91 56 174215 30553 50400300
Fracture pain 13.99 9.91 11 174260 359 50430494
Lower respiratory tract infection 13.97 9.91 428 173843 94773 50336080
Product packaging confusion 13.96 9.91 8 174263 152 50430701
Myelodysplastic syndrome 13.94 9.91 19 174252 15113 50415740
Electrocardiogram QT prolonged 13.92 9.91 113 174158 51773 50379080
Mucosal discolouration 13.86 9.91 12 174259 449 50430404
Gallbladder disorder 13.85 9.91 102 174169 16640 50414213
Sinus headache 13.84 9.91 41 174230 4557 50426296
Oxygen consumption decreased 13.74 9.91 9 174262 219 50430634
Exposure to fungus 13.74 9.91 7 174264 104 50430749
Injection site scab 13.68 9.91 11 174260 371 50430482
Squamous cell carcinoma of the oral cavity 13.59 9.91 10 174261 295 50430558
Blood immunoglobulin E decreased 13.53 9.91 6 174265 64 50430789
Sputum retention 13.46 9.91 12 174259 467 50430386
Overdose 13.45 9.91 252 174019 99475 50331378
Functional residual capacity decreased 13.37 9.91 6 174265 66 50430787
Metastases to lung 13.33 9.91 11 174260 11009 50419844
Laryngeal oedema 13.30 9.91 43 174228 5010 50425843
PCO2 increased 13.30 9.91 18 174253 1125 50429728
Respiratory tract infection viral 13.27 9.91 23 174248 1786 50429067
Foot deformity 13.24 9.91 29 174242 19181 50411672
Premature baby 13.21 9.91 27 174244 18310 50412543
Depressed mood 13.20 9.91 177 174094 33846 50397007
Forced expiratory volume 13.20 9.91 4 174267 12 50430841
Blood lactate dehydrogenase increased 13.10 9.91 30 174241 19532 50411321
Product dispensing error 13.08 9.91 63 174208 8828 50422025
Pulmonary embolism 13.05 9.91 450 173821 101254 50329599
Accidental overdose 13.05 9.91 30 174241 19503 50411350
Melaena 13.02 9.91 48 174223 26816 50404037
Sinus operation 13.02 9.91 22 174249 1674 50429179
Mandibular mass 13 9.91 8 174263 174 50430679
Functional residual capacity increased 12.98 9.91 6 174265 71 50430782
Breast cancer metastatic 12.97 9.91 10 174261 10354 50420499
Administration site swelling 12.97 9.91 17 174254 1030 50429823
Epilepsy 12.94 9.91 35 174236 21532 50409321
Muscle rigidity 12.93 9.91 9 174262 9820 50421033
Cardiac disorder 12.92 9.91 214 174057 42765 50388088
Joint stiffness 12.90 9.91 57 174214 30251 50400602
Miosis 12.79 9.91 3 174268 6307 50424546
Female reproductive neoplasm 12.75 9.91 5 174266 38 50430815
Product appearance confusion 12.75 9.91 5 174266 38 50430815
Cold agglutinins positive 12.75 9.91 5 174266 38 50430815
Abnormal weight gain 12.73 9.91 20 174251 1432 50429421
Sinus bradycardia 12.72 9.91 16 174255 13167 50417686
Diverticulum 12.70 9.91 71 174200 10543 50420310
Ligament pain 12.68 9.91 8 174263 182 50430671
Sleep disorder 12.66 9.91 272 173999 57011 50373842
Oropharyngitis fungal 12.63 9.91 5 174266 39 50430814
Therapeutic response unexpected 12.62 9.91 96 174175 15819 50415034
Haemophagocytic lymphohistiocytosis 12.61 9.91 7 174264 8626 50422227
Type 2 diabetes mellitus 12.59 9.91 177 174094 34198 50396655
Product taste abnormal 12.56 9.91 22 174249 1723 50429130
Posterior reversible encephalopathy syndrome 12.53 9.91 20 174251 14908 50415945
Eczema impetiginous 12.52 9.91 4 174267 15 50430838
Middle ear effusion 12.49 9.91 24 174247 2019 50428834
Hepatic encephalopathy 12.44 9.91 9 174262 9627 50421226
Inhalation therapy 12.42 9.91 5 174266 41 50430812
Neuropsychiatric syndrome 12.42 9.91 5 174266 41 50430812
Hypereosinophilic syndrome 12.39 9.91 9 174262 260 50430593
Schizophrenia 12.33 9.91 5 174266 7392 50423461
Proteinuria 12.33 9.91 24 174247 16573 50414280
Ligament sprain 12.32 9.91 70 174201 10455 50420398
Hypothermia 12.21 9.91 14 174257 12002 50418851
Amnesia 12.19 9.91 209 174062 42051 50388802
Upper limb fracture 12.17 9.91 95 174176 15778 50415075
Pneumonia respiratory syncytial viral 12.11 9.91 13 174258 637 50430216
Hyperplastic cholecystopathy 12.09 9.91 6 174265 84 50430769
Depressive symptom 12.08 9.91 31 174240 3169 50427684
Administration site pruritus 12.07 9.91 9 174262 271 50430582
Acute generalised exanthematous pustulosis 12.00 9.91 8 174263 8930 50421923
Distal intestinal obstruction syndrome 12.00 9.91 10 174261 355 50430498
Otorrhoea 11.99 9.91 18 174253 1238 50429615
Infusion site nodule 11.99 9.91 17 174254 1110 50429743
Diverticulum oesophageal 11.98 9.91 7 174264 138 50430715
Platelet adhesiveness decreased 11.96 9.91 3 174268 3 50430850
Polymorphic eruption of pregnancy 11.96 9.91 3 174268 3 50430850
Oral pruritus 11.88 9.91 21 174250 1657 50429196
Respiratory arrest 11.85 9.91 58 174213 29951 50400902
Body temperature abnormal 11.84 9.91 18 174253 1252 50429601
Hallucination 11.79 9.91 226 174045 46431 50384422
Cephalo-pelvic disproportion 11.78 9.91 8 174263 207 50430646
Mouth ulceration 11.75 9.91 53 174218 27971 50402882
Malnutrition 11.72 9.91 17 174254 13172 50417681
Jaundice 11.68 9.91 49 174222 26380 50404473
Vaccination complication 11.63 9.91 14 174257 778 50430075
Injection site hypoaesthesia 11.60 9.91 10 174261 372 50430481
Blood parathyroid hormone decreased 11.55 9.91 5 174266 7109 50423744
Low birth weight baby 11.52 9.91 3 174268 5878 50424975
School refusal 11.50 9.91 3 174268 4 50430849
Pulmonary arterial hypertension 11.44 9.91 34 174237 20285 50410568
Blood calcium decreased 11.40 9.91 35 174236 20671 50410182
Screaming 11.40 9.91 29 174242 2949 50427904
Infusion site mass 11.26 9.91 17 174254 1175 50429678
Fungal infection 11.26 9.91 155 174116 29810 50401043
Clostridium difficile colitis 11.25 9.91 28 174243 17714 50413139
Diastolic dysfunction 11.25 9.91 42 174229 5260 50425593
Phlebectomy 11.22 9.91 5 174266 54 50430799
Cardiogenic shock 11.21 9.91 23 174248 15576 50415277
Pulmonary renal syndrome 11.20 9.91 10 174261 390 50430463
Product prescribing error 11.14 9.91 36 174235 20925 50409928
Serum sickness 11.13 9.91 26 174245 2506 50428347
Fear 11.12 9.91 87 174184 14462 50416391
Stress urinary incontinence 11.11 9.91 23 174248 2042 50428811
Hearing aid user 11.06 9.91 5 174266 56 50430797
Self-injurious ideation 11.04 9.91 24 174247 2205 50428648
Eye swelling 11.03 9.91 112 174159 20032 50410821
Microscopic polyangiitis 10.99 9.91 7 174264 162 50430691
Snoring 10.98 9.91 31 174240 3353 50427500
Obsessive thoughts 10.96 9.91 11 174260 498 50430355
Hospitalisation 10.94 9.91 309 173962 67628 50363225
Coagulopathy 10.86 9.91 29 174242 17915 50412938
Neuropathy peripheral 10.83 9.91 252 174019 96505 50334348
Female sterilisation 10.83 9.91 11 174260 505 50430348
Peak expiratory flow rate increased 10.75 9.91 3 174268 6 50430847
Dyslipidaemia 10.74 9.91 45 174226 5943 50424910
Poisoning deliberate 10.74 9.91 7 174264 7905 50422948
Blood cholesterol increased 10.72 9.91 130 174141 55085 50375768
PO2 decreased 10.71 9.91 18 174253 1363 50429490
Hypertensive crisis 10.69 9.91 18 174253 13136 50417717
Speech disorder 10.69 9.91 177 174094 35371 50395482
Injection site discomfort 10.66 9.91 33 174238 3757 50427096
Atrioventricular block first degree 10.66 9.91 4 174267 6197 50424656
Lung diffusion disorder 10.61 9.91 5 174266 62 50430791
Pulmonary toxicity 10.59 9.91 3 174268 5559 50425294
Pertussis 10.57 9.91 12 174259 626 50430227
Lacrimation increased 10.55 9.91 97 174174 16895 50413958
Vasomotor rhinitis 10.54 9.91 5 174266 63 50430790
Basal cell carcinoma 10.51 9.91 43 174228 23313 50407540
Prothrombin time prolonged 10.47 9.91 9 174262 8829 50422024
Cushingoid 10.44 9.91 48 174223 6597 50424256
Uveitis 10.41 9.91 10 174261 9300 50421553
Joint range of motion decreased 10.40 9.91 31 174240 18481 50412372
Congenital naevus 10.38 9.91 7 174264 179 50430674
Herpes zoster oticus 10.36 9.91 8 174263 254 50430599
Glossitis 10.32 9.91 26 174245 2629 50428224
Flushing 10.29 9.91 303 173968 66712 50364141
Cerebral haemorrhage 10.27 9.91 53 174218 26999 50403854
Chronic gastrointestinal bleeding 10.24 9.91 6 174265 119 50430734
Unintentional medical device removal 10.23 9.91 3 174268 5432 50425421
Infusion site warmth 10.22 9.91 18 174253 1416 50429437
Aplastic anaemia 10.20 9.91 7 174264 7696 50423157
Oliguria 10.19 9.91 8 174263 8208 50422645
Erysipelas 10.18 9.91 5 174266 6603 50424250
Renal tubular necrosis 10.17 9.91 12 174259 10156 50420697
Forced expiratory volume abnormal 10.14 9.91 5 174266 69 50430784
Alice in wonderland syndrome 10.13 9.91 4 174267 31 50430822
Animal scratch 10.13 9.91 14 174257 893 50429960
Urinary retention 10.12 9.91 51 174220 26139 50404714
Device expulsion 10.10 9.91 58 174213 28764 50402089
Muscle spasms 10.10 9.91 529 173742 125024 50305829
Nasal discomfort 10.08 9.91 33 174238 3871 50426982
Mycobacterium avium complex infection 10.07 9.91 25 174246 2505 50428348
Breast neoplasm 10.04 9.91 17 174254 1296 50429557
Painful respiration 10.02 9.91 24 174247 2351 50428502
Hypertension 10.01 9.91 851 173420 210352 50220501
Cytokine release syndrome 9.98 9.91 9 174262 8625 50422228
Hyperventilation 9.98 9.91 41 174230 5368 50425485
Laryngeal stenosis 9.96 9.91 13 174258 784 50430069
SARS-CoV-2 test positive 9.96 9.91 37 174234 4622 50426231
Axonal neuropathy 9.92 9.91 14 174257 910 50429943
Administration site bruise 9.92 9.91 8 174263 271 50430582
Cold urticaria 9.91 9.91 4 174267 33 50430820

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 2789.20 10.91 1439 69658 32410 29471020
Wheezing 1177.76 10.91 822 70275 32418 29471012
Eosinophilic granulomatosis with polyangiitis 837.56 10.91 251 70846 1135 29502295
Obstructive airways disorder 656.90 10.91 379 70718 10637 29492793
Full blood count abnormal 441.45 10.91 332 70765 14681 29488749
Cough 440.33 10.91 952 70145 125775 29377655
Forced expiratory volume decreased 424.24 10.91 182 70915 2631 29500799
Sleep terror 412.51 10.91 126 70971 615 29502815
Productive cough 346.38 10.91 401 70696 30858 29472572
Suicidal ideation 342.94 10.91 420 70677 34296 29469134
Abnormal behaviour 339.13 10.91 344 70753 22783 29480647
Dyspnoea 316.38 10.91 1583 69514 325149 29178281
Aggression 289.77 10.91 391 70706 35150 29468280
Sleep disorder due to a general medical condition 270.43 10.91 138 70959 3008 29500422
Therapeutic product effect incomplete 262.27 10.91 393 70704 38912 29464518
Toxicity to various agents 258.11 10.91 52 71045 173609 29329821
Nightmare 257.31 10.91 216 70881 11201 29492229
Anger 235.10 10.91 201 70896 10689 29492741
Sputum discoloured 221.95 10.91 158 70939 6405 29497025
Nasal congestion 220.54 10.91 249 70848 18630 29484800
Middle insomnia 217.82 10.91 148 70949 5560 29497870
Chest discomfort 210.26 10.91 388 70709 45595 29457835
Sinusitis 199.17 10.91 322 70775 34028 29469402
Acute kidney injury 169.25 10.91 235 70862 265032 29238398
Blood immunoglobulin E increased 166.16 10.91 85 71012 1862 29501568
Loss of personal independence in daily activities 162.00 10.91 249 70848 25191 29478239
Nasal polyps 159.05 10.91 80 71017 1689 29501741
Anaemia 156.10 10.91 152 70945 200799 29302631
Anxiety 152.00 10.91 501 70596 84864 29418566
Depression 143.86 10.91 491 70606 84656 29418774
Pulmonary function test decreased 137.95 10.91 99 70998 4064 29499366
Mood altered 136.22 10.91 130 70967 7981 29495449
Bronchial wall thickening 123.12 10.91 57 71040 995 29502435
Infective pulmonary exacerbation of cystic fibrosis 122.30 10.91 109 70988 6127 29497303
Crying 122.12 10.91 102 70995 5249 29498181
Death 116.62 10.91 427 70670 341657 29161773
Eosinophilia 111.44 10.91 195 70902 21966 29481464
Febrile neutropenia 108.39 10.91 68 71029 112172 29391258
Thrombocytopenia 108.06 10.91 99 70998 134724 29368706
Drug interaction 107.55 10.91 194 70903 197191 29306239
Gastrooesophageal reflux disease 104.79 10.91 233 70864 31263 29472167
Urticaria 103.71 10.91 328 70769 54332 29449098
Nasopharyngitis 103.28 10.91 347 70750 59318 29444112
Rhinorrhoea 101.33 10.91 184 70913 21335 29482095
Eosinophil count increased 99.62 10.91 105 70992 7264 29496166
Bronchial secretion retention 97.41 10.91 50 71047 1103 29502327
Chronic obstructive pulmonary disease 97.03 10.91 266 70831 40689 29462741
Pulmonary function test abnormal 96.55 10.91 61 71036 2021 29501409
Bronchiectasis 96.54 10.91 98 70999 6487 29496943
Asthmatic crisis 90.04 10.91 35 71062 386 29503044
Sleep disorder 87.50 10.91 186 70911 24200 29479230
Bronchospasm 86.39 10.91 111 70986 9498 29493932
Dyspnoea exertional 83.46 10.91 234 70863 36256 29467174
Bronchitis 82.93 10.91 235 70862 36633 29466797
Rhinitis 82.93 10.91 78 71019 4700 29498730
Bronchial hyperreactivity 82.75 10.91 48 71049 1358 29502072
Pancytopenia 82.19 10.91 49 71048 83119 29420311
Upper-airway cough syndrome 80.72 10.91 63 71034 2940 29500490
Bronchial obstruction 80.58 10.91 47 71050 1344 29502086
Seasonal allergy 80.45 10.91 79 71018 5023 29498407
Influenza 80.04 10.91 252 70845 41629 29461801
Hypotension 79.71 10.91 223 70874 194131 29309299
Eosinophilic pneumonia chronic 78.69 10.91 25 71072 142 29503288
Irritability 77.21 10.91 167 70930 21985 29481445
Neutropenia 76.65 10.91 124 70973 131587 29371843
Off label use 76.13 10.91 419 70678 300381 29203049
Tic 75.82 10.91 50 71047 1785 29501645
Right atrial hypertrophy 74.96 10.91 33 71064 509 29502921
Vital capacity decreased 73.71 10.91 29 71068 331 29503099
Malignant neoplasm progression 73.71 10.91 43 71054 73816 29429614
Drug abuse 73.56 10.91 51 71046 79832 29423598
Sensitivity to weather change 71.94 10.91 44 71053 1375 29502055
Screaming 71.17 10.91 42 71055 1228 29502202
Blood creatinine increased 71.13 10.91 60 71037 85042 29418388
Psychomotor hyperactivity 70.91 10.91 93 71004 8120 29495310
Ear infection 70.37 10.91 92 71005 8008 29495422
Mood swings 70.33 10.91 87 71010 7164 29496266
Breath sounds abnormal 67.17 10.91 74 71023 5383 29498047
Multiple organ dysfunction syndrome 66.97 10.91 34 71063 63082 29440348
Hypersensitivity 65.96 10.91 277 70820 52626 29450804
Sepsis 65.14 10.91 155 70942 142527 29360903
Renal failure 65.00 10.91 116 70981 118483 29384947
Photodermatosis 63.65 10.91 28 71069 431 29502999
Headache 62.95 10.91 667 70430 173340 29330090
Solar lentigo 62.93 10.91 27 71070 390 29503040
Dysplastic naevus 62.19 10.91 27 71070 402 29503028
Obstruction 61.98 10.91 45 71052 1881 29501549
Leukopenia 61.22 10.91 28 71069 55175 29448255
Confusional state 60.71 10.91 136 70961 127741 29375689
Lower respiratory tract infection 60.64 10.91 170 70927 26332 29477098
Bronchopulmonary aspergillosis allergic 60.41 10.91 28 71069 490 29502940
Haemoglobin decreased 60.28 10.91 105 70992 108270 29395160
Hyponatraemia 59.88 10.91 45 71052 67588 29435842
Vocal cord dysfunction 59.17 10.91 20 71077 142 29503288
Sleep apnoea syndrome 58.30 10.91 130 70967 17469 29485961
Sneezing 58.07 10.91 62 71035 4352 29499078
Respiratory tract congestion 57.50 10.91 67 71030 5182 29498248
Asthma-chronic obstructive pulmonary disease overlap syndrome 56.43 10.91 30 71067 713 29502717
Upper respiratory tract infection 56.37 10.91 169 70928 27180 29476250
Blood cholesterol 56.25 10.91 20 71077 168 29503262
Completed suicide 54.33 10.91 83 71014 90163 29413267
Blood pressure systolic increased 54.20 10.91 123 70974 16722 29486708
Allergy to animal 53.43 10.91 21 71076 239 29503191
Social avoidant behaviour 52.93 10.91 49 71048 2893 29500537
Victim of child abuse 52.81 10.91 30 71067 815 29502615
Depressed mood 51.70 10.91 119 70978 16329 29487101
Nasal disorder 51.57 10.91 36 71061 1413 29502017
Right ventricular hypertrophy 51.31 10.91 33 71064 1128 29502302
Heart rate increased 50.98 10.91 207 70890 38731 29464699
Educational problem 50.83 10.91 25 71072 502 29502928
Blood pressure increased 50.52 10.91 327 70770 73476 29429954
Eye pruritus 50.32 10.91 57 71040 4275 29499155
Dyspnoea at rest 49.25 10.91 49 71048 3165 29500265
Sputum increased 48.73 10.91 39 71058 1888 29501542
Insomnia 48.32 10.91 372 70725 88389 29415041
Rhabdomyolysis 48.24 10.91 45 71052 60763 29442667
Osteoporosis 48.06 10.91 90 71007 10679 29492751
Product quality issue 47.77 10.91 113 70984 15782 29487648
Dehydration 47.45 10.91 131 70966 114617 29388813
Anaphylactic reaction 47.34 10.91 160 70937 27413 29476017
Suffocation feeling 47.23 10.91 24 71073 518 29502912
Diarrhoea 46.99 10.91 543 70554 332155 29171275
Septic shock 46.52 10.91 49 71048 62511 29440919
Impaired quality of life 45.92 10.91 43 71054 2576 29500854
Platelet count decreased 44.40 10.91 118 70979 104554 29398876
Chronic sinusitis 44.06 10.91 35 71062 1676 29501754
Dermatitis atopic 43.93 10.91 39 71058 2180 29501250
Aspirin-exacerbated respiratory disease 43.36 10.91 20 71077 346 29503084
Eosinophil count 43.05 10.91 15 71082 118 29503312
Forced vital capacity decreased 42.75 10.91 24 71073 637 29502793
Personality change 42.35 10.91 54 71043 4584 29498846
Gastrointestinal haemorrhage 41.58 10.91 80 71017 79453 29423977
Emotional disorder 41.27 10.91 55 71042 4876 29498554
Eye swelling 40.71 10.91 74 71023 8583 29494847
Panic attack 40.21 10.91 72 71025 8254 29495176
Body temperature decreased 40.17 10.91 83 71014 10581 29492849
Renal impairment 39.80 10.91 85 71012 81248 29422182
Anosmia 39.43 10.91 35 71062 1956 29501474
Rhinitis perennial 39.23 10.91 16 71081 202 29503228
Disease progression 38.13 10.91 88 71009 81828 29421602
Nasal inflammation 38.07 10.91 16 71081 219 29503211
Multiple allergies 37.80 10.91 35 71062 2067 29501363
Cardiac arrest 37.43 10.91 95 71002 85496 29417934
Bone marrow failure 37.14 10.91 10 71087 27439 29475991
Reversible airways obstruction 37.05 10.91 16 71081 235 29503195
Product dose omission issue 36.92 10.91 374 70723 96009 29407421
Food allergy 36.34 10.91 25 71072 958 29502472
Pruritus 36.31 10.91 435 70662 116414 29387016
Oropharyngeal pain 36.21 10.91 153 70944 29132 29474298
Restrictive pulmonary disease 36.16 10.91 26 71071 1070 29502360
Eczema 35.95 10.91 93 71004 13733 29489697
Respiratory disorder 35.04 10.91 105 70992 16878 29486552
Sinus congestion 34.91 10.91 49 71048 4563 29498867
Foetal exposure during pregnancy 34.80 10.91 19 71078 33848 29469582
Aortic valve stenosis 34.46 10.91 34 71063 2174 29501256
Eye disorder 34.37 10.91 65 71032 7769 29495661
Respiratory rate increased 34.25 10.91 69 71028 8639 29494791
Nasal oedema 34.21 10.91 16 71081 286 29503144
Ascites 34.19 10.91 23 71074 36596 29466834
Hypoventilation 34.06 10.91 38 71059 2803 29500627
Cardio-respiratory arrest 33.97 10.91 43 71054 50558 29452872
Stress 33.68 10.91 121 70976 21369 29482061
Hyperkalaemia 33.64 10.91 60 71037 61332 29442098
Negative thoughts 33.22 10.91 20 71077 607 29502823
Pleural effusion 32.86 10.91 78 71019 71830 29431600
Myocardial infarction 32.74 10.91 145 70952 110151 29393279
Peak expiratory flow rate decreased 32.46 10.91 12 71085 114 29503316
Perfume sensitivity 32.08 10.91 11 71086 82 29503348
Smoke sensitivity 32 10.91 12 71085 119 29503311
Morbid thoughts 31.80 10.91 14 71083 216 29503214
Status asthmaticus 31.63 10.91 15 71082 277 29503153
Respiratory tract infection 31.57 10.91 96 71001 15555 29487875
Coma 31.51 10.91 29 71068 39421 29464009
Illness 31.32 10.91 57 71040 6617 29496813
Sputum purulent 31.31 10.91 17 71080 422 29503008
Rhinitis allergic 30.68 10.91 35 71062 2645 29500785
Malaise 30.15 10.91 545 70552 159057 29344373
Intentional overdose 29.97 10.91 29 71068 38499 29464931
Chest X-ray abnormal 29.75 10.91 41 71056 3753 29499677
Dust allergy 29.59 10.91 17 71080 472 29502958
Cystic fibrosis 29.09 10.91 26 71071 1466 29501964
Drug resistance 28.86 10.91 8 71089 21532 29481898
Cardiac failure 28.83 10.91 96 71001 79191 29424239
Lung hyperinflation 28.49 10.91 20 71077 792 29502638
Hypokalaemia 28.47 10.91 48 71049 50155 29453275
Eosinophilic bronchitis 28.43 10.91 12 71085 166 29503264
General physical health deterioration 28.29 10.91 139 70958 102718 29400712
Nasal discharge discolouration 28.28 10.91 13 71084 223 29503207
Ocular discomfort 28.22 10.91 27 71070 1662 29501768
Excessive eye blinking 28.19 10.91 16 71081 434 29502996
Blood test abnormal 28.12 10.91 50 71047 5699 29497731
Total lung capacity abnormal 28.08 10.91 11 71086 124 29503306
Hepatic failure 27.83 10.91 21 71076 31491 29471939
Pleural thickening 27.77 10.91 14 71083 297 29503133
Acute myocardial infarction 27.76 10.91 46 71051 48392 29455038
Throat tightness 27.66 10.91 56 71041 7035 29496395
Nasal discomfort 27.44 10.91 23 71074 1189 29502241
Homicidal ideation 27.28 10.91 32 71065 2492 29500938
Blebitis 27.14 10.91 6 71091 4 29503426
Suicidal behaviour 27.04 10.91 24 71073 1341 29502089
Hypereosinophilic syndrome 26.58 10.91 12 71085 197 29503233
Endocarditis fibroplastica 26.57 10.91 6 71091 5 29503425
Discomfort 26.52 10.91 87 71010 14676 29488754
International normalised ratio increased 26.50 10.91 41 71056 44331 29459099
Agranulocytosis 26.43 10.91 8 71089 20332 29483098
Snoring 26.35 10.91 33 71064 2751 29500679
Product substitution issue 26.26 10.91 64 71033 9108 29494322
Blood immunoglobulin G decreased 26.25 10.91 22 71075 1137 29502293
Attention-seeking behaviour 26.19 10.91 8 71089 39 29503391
Sinus polyp 25.95 10.91 11 71086 154 29503276
Delirium 25.90 10.91 34 71063 39363 29464067
Panic reaction 25.81 10.91 23 71074 1292 29502138
Neuroleptic malignant syndrome 25.74 10.91 4 71093 16144 29487286
Attention deficit hyperactivity disorder 25.46 10.91 29 71068 2188 29501242
Oesophageal polyp 25.40 10.91 8 71089 44 29503386
Metabolic acidosis 25.28 10.91 32 71065 37630 29465800
Rheumatoid arthritis 25.24 10.91 24 71073 32128 29471302
Tearfulness 25.17 10.91 25 71072 1611 29501819
Haematemesis 25.03 10.91 14 71083 24612 29478818
Throat irritation 24.83 10.91 61 71036 8724 29494706
Pigment dispersion syndrome 24.72 10.91 6 71091 9 29503421
Pneumonia 24.58 10.91 971 70126 319201 29184229
Obesity 24.27 10.91 65 71032 9798 29493632
Cerebral haemorrhage 24.05 10.91 24 71073 31402 29472028
Cytomegalovirus infection 23.88 10.91 13 71084 23202 29480228
Epidural lipomatosis 23.76 10.91 17 71080 694 29502736
Fear 23.76 10.91 63 71034 9441 29493989
Blood lactic acid 23.57 10.91 13 71084 333 29503097
Syncope 23.52 10.91 108 70989 81263 29422167
Hyperkaliuria 23.50 10.91 9 71088 95 29503335
Enuresis 23.49 10.91 27 71070 2057 29501373
Bradycardia 23.49 10.91 80 71017 65549 29437881
Sinus disorder 23.20 10.91 47 71050 5908 29497522
Mucosal inflammation 23.19 10.91 25 71072 31570 29471860
Electrocardiogram QT prolonged 22.94 10.91 32 71065 36105 29467325
Dysphonia 22.73 10.91 99 70998 19097 29484333
C-reactive protein increased 22.71 10.91 45 71052 44218 29459212
Self-injurious ideation 22.58 10.91 23 71074 1528 29501902
Nausea 22.46 10.91 527 70570 288728 29214702
Cardiogenic shock 22.43 10.91 9 71088 19181 29484249
Bronchiolitis obliterans syndrome 22.38 10.91 10 71087 160 29503270
Contraindicated product administered 22.30 10.91 8 71089 18258 29485172
Intervertebral disc degeneration 22.26 10.91 43 71054 5221 29498209
Diastolic dysfunction 22.19 10.91 42 71055 5022 29498408
Meningitis eosinophilic 22.18 10.91 6 71091 17 29503413
Temperature intolerance 22.06 10.91 31 71066 2890 29500540
Lower respiratory tract congestion 22.04 10.91 19 71078 1021 29502409
NPM1 gene mutation 21.83 10.91 9 71088 117 29503313
White blood cell count decreased 21.58 10.91 115 70982 83247 29420183
Polyp 21.58 10.91 32 71065 3133 29500297
Rhonchi 21.53 10.91 23 71074 1615 29501815
Urinary tract infection 21.52 10.91 95 71002 72259 29431171
Melaena 21.44 10.91 26 71071 31150 29472280
Neoplasm progression 21.32 10.91 9 71088 18603 29484827
Tubulointerstitial nephritis 21.08 10.91 8 71089 17635 29485795
Stiff person syndrome 21.01 10.91 8 71089 83 29503347
Neutrophil count decreased 20.91 10.91 46 71051 43521 29459909
Asthenia 20.89 10.91 378 70719 214872 29288558
Palmar-plantar erythrodysaesthesia syndrome 20.69 10.91 5 71092 14754 29488676
Abnormal dreams 20.58 10.91 49 71048 6871 29496559
Deep vein thrombosis 20.51 10.91 70 71027 57329 29446101
Allergic respiratory disease 20.41 10.91 6 71091 25 29503405
Encephalopathy 20.19 10.91 27 71070 31016 29472414
Pyrexia 20.17 10.91 532 70565 287090 29216340
Lactic acidosis 19.99 10.91 26 71071 30221 29473209
Throat clearing 19.80 10.91 10 71087 213 29503217
Scleroderma 19.77 10.91 20 71077 1318 29502112
Nocturnal dyspnoea 19.66 10.91 13 71084 466 29502964
Blood bilirubin increased 19.59 10.91 32 71065 33861 29469569
Gastroenteritis viral 19.52 10.91 43 71054 5729 29497701
Migraine 19.48 10.91 70 71027 12360 29491070
Cerebrovascular accident 19.41 10.91 107 70990 76804 29426626
Physical assault 19.39 10.91 18 71079 1066 29502364
Lung hernia 19.36 10.91 7 71090 62 29503368
Hypoglycaemia 19.36 10.91 56 71041 48290 29455140
Acute respiratory distress syndrome 19.35 10.91 16 71081 22919 29480511
Cortisol decreased 19.29 10.91 16 71081 815 29502615
Forced expiratory flow decreased 19.24 10.91 9 71088 161 29503269
Affective disorder 19.05 10.91 30 71067 3096 29500334
Stomatitis 18.80 10.91 38 71059 37075 29466355
Self esteem decreased 18.76 10.91 13 71084 504 29502926
Blood urea increased 18.75 10.91 24 71073 28088 29475342
Secretion discharge 18.55 10.91 35 71062 4175 29499255
Mast cell activation syndrome 18.47 10.91 9 71088 177 29503253
Hyperglycaemia 18.33 10.91 34 71063 34253 29469177
Hypohidrosis 17.89 10.91 9 71088 190 29503240
Alopecia areata 17.85 10.91 9 71088 191 29503239
Haematuria 17.77 10.91 51 71046 44088 29459342
Treatment failure 17.73 10.91 39 71058 36900 29466530
Hepatocellular injury 17.70 10.91 15 71082 21228 29482202
Benign prostatic hyperplasia 17.55 10.91 65 71032 11645 29491785
Respiratory symptom 17.49 10.91 16 71081 930 29502500
Steroid diabetes 17.45 10.91 21 71076 1680 29501750
Respiratory tract irritation 17.42 10.91 8 71089 137 29503293
Poor quality device used 17.41 10.91 15 71082 805 29502625
Acute myeloid leukaemia 17.35 10.91 9 71088 16504 29486926
Airway remodelling 17.31 10.91 8 71089 139 29503291
Nasal septum deviation 17.30 10.91 16 71081 943 29502487
Unresponsive to stimuli 17.23 10.91 21 71076 25105 29478325
Mononeuropathy multiplex 17.21 10.91 8 71089 141 29503289
Mental disorder 17.19 10.91 69 71028 12836 29490594
Asthma exercise induced 17.19 10.91 7 71090 88 29503342
Eosinophilic oesophagitis 17.08 10.91 9 71088 210 29503220
Bronchitis viral 16.96 10.91 9 71088 213 29503217
Neuropsychiatric symptoms 16.94 10.91 12 71085 482 29502948
Sopor 16.78 10.91 3 71094 10931 29492499
Upper respiratory tract congestion 16.75 10.91 14 71083 721 29502709
Adjustment disorder 16.72 10.91 16 71081 985 29502445
Alanine aminotransferase increased 16.67 10.91 101 70996 70843 29432587
Altered state of consciousness 16.63 10.91 14 71083 19875 29483555
Chimerism 16.63 10.91 9 71088 222 29503208
Feeling abnormal 16.58 10.91 202 70895 54243 29449187
Constipation 16.54 10.91 185 70912 113975 29389455
Pneumocystis jirovecii pneumonia 16.40 10.91 10 71087 16769 29486661
Oropharyngeal discomfort 16.23 10.91 25 71072 2531 29500899
Bronchiolitis 16.18 10.91 26 71071 2729 29500701
Sedation 16.15 10.91 11 71086 17394 29486036
Hyperbilirubinaemia 15.90 10.91 8 71089 14926 29488504
Behaviour disorder 15.86 10.91 30 71067 3586 29499844
Sputum abnormal 15.77 10.91 11 71086 431 29502999
Disseminated intravascular coagulation 15.58 10.91 15 71082 19965 29483465
Small airways disease 15.51 10.91 5 71092 30 29503400
Hostility 15.46 10.91 14 71083 803 29502627
Obsessive-compulsive disorder 15.37 10.91 34 71063 4542 29498888
Total lung capacity decreased 15.30 10.91 12 71085 564 29502866
Haemophilus infection 15.29 10.91 15 71082 952 29502478
Decreased appetite 15.12 10.91 252 70845 145090 29358340
Seizure anoxic 15.10 10.91 3 71094 0 29503430
Exophthalmos congenital 15.10 10.91 3 71094 0 29503430
Cephalo-pelvic disproportion 15.10 10.91 3 71094 0 29503430
ACTH stimulation test abnormal 15.10 10.91 3 71094 0 29503430
Pigmentary glaucoma 15.10 10.91 3 71094 0 29503430
Fall 15.09 10.91 318 70779 176860 29326570
Hemiparesis 15.06 10.91 8 71089 14478 29488952
Idiopathic intracranial hypertension 14.96 10.91 12 71085 583 29502847
Oedema peripheral 14.92 10.91 168 70929 103389 29400041
Human ehrlichiosis 14.86 10.91 8 71089 195 29503235
Growth retardation 14.86 10.91 19 71078 1617 29501813
Drug level increased 14.77 10.91 14 71083 18773 29484657
Pulmonary oedema 14.67 10.91 53 71044 42682 29460748
Depressed level of consciousness 14.64 10.91 43 71054 36899 29466531
Allergy to plants 14.62 10.91 4 71093 12 29503418
Circulatory collapse 14.58 10.91 14 71083 18659 29484771
Angina pectoris 14.55 10.91 28 71069 27822 29475608
Bone density decreased 14.46 10.91 19 71078 1661 29501769
Swelling face 14.41 10.91 91 71006 20259 29483171
Device related infection 14.35 10.91 10 71087 15626 29487804
Disturbance in social behaviour 14.27 10.91 19 71078 1683 29501747
Frustration tolerance decreased 14.26 10.91 22 71075 2230 29501200
Peritonitis 14.26 10.91 9 71088 14815 29488615
Vomiting 14.22 10.91 395 70702 211865 29291565
Subarachnoid haemorrhage 14.15 10.91 3 71094 9689 29493741
Juvenile idiopathic arthritis 13.96 10.91 17 71080 1377 29502053
Shock haemorrhagic 13.86 10.91 3 71094 9548 29493882
Sputum retention 13.86 10.91 10 71087 414 29503016
Prostatomegaly 13.85 10.91 33 71064 4628 29498802
Hepatic encephalopathy 13.85 10.91 7 71090 13028 29490402
Diabetic ketoacidosis 13.83 10.91 11 71086 16062 29487368
Glaucoma 13.81 10.91 38 71059 5819 29497611
Subdural haematoma 13.80 10.91 14 71083 18179 29485251
Prolonged expiration 13.78 10.91 7 71090 151 29503279
Intentional product use issue 13.75 10.91 54 71043 42444 29460986
Nasal mucosal disorder 13.72 10.91 6 71091 91 29503339
Vasculitis 13.60 10.91 46 71051 7882 29495548
Weight increased 13.47 10.91 259 70838 76408 29427022
Renal tubular necrosis 13.35 10.91 9 71088 14306 29489124
Hypercalcaemia 13.33 10.91 7 71090 12752 29490678
Haematochezia 13.28 10.91 45 71052 36938 29466492
Facial discomfort 13.01 10.91 4 71093 20 29503410
Haematocrit decreased 12.84 10.91 32 71065 28990 29474440
Stridor 12.81 10.91 21 71076 2242 29501188
Extrapyramidal disorder 12.79 10.91 5 71092 10826 29492604
Central obesity 12.75 10.91 10 71087 470 29502960
Clostridium difficile colitis 12.74 10.91 8 71089 13204 29490226
Pulmonary embolism 12.73 10.91 120 70977 76414 29427016
Respiration abnormal 12.71 10.91 23 71074 2657 29500773
Kidney infection 12.69 10.91 32 71065 4651 29498779
Hypomagnesaemia 12.62 10.91 14 71083 17454 29485976
Interstitial lung disease 12.62 10.91 84 71013 57634 29445796
Agitation 12.57 10.91 183 70914 51121 29452309
Bronchopulmonary aspergillosis 12.57 10.91 7 71090 12337 29491093
Breath holding 12.57 10.91 3 71094 4 29503426
Spirometry abnormal 12.57 10.91 9 71088 368 29503062
Separation anxiety disorder 12.57 10.91 3 71094 4 29503426
Product taste abnormal 12.54 10.91 14 71083 1033 29502397
Aspartate aminotransferase increased 12.52 10.91 88 71009 59637 29443793
Choking 12.50 10.91 31 71066 4460 29498970
Conjunctivitis 12.50 10.91 45 71052 7953 29495477
Dysphagia 12.48 10.91 79 71018 54847 29448583
Eosinophil count abnormal 12.45 10.91 8 71089 273 29503157
Gastrointestinal tract mucosal pigmentation 12.44 10.91 9 71088 374 29503056
Onychophagia 12.20 10.91 5 71092 64 29503366
Hepatotoxicity 12.18 10.91 15 71082 17852 29485578
Fight in school 12.17 10.91 3 71094 5 29503425
Lymphopenia 11.97 10.91 9 71088 13524 29489906
Anuria 11.95 10.91 4 71093 9537 29493893
Quality of life decreased 11.83 10.91 25 71072 3237 29500193
Weight decreased 11.83 10.91 459 70638 150446 29352984
Liver function test decreased 11.79 10.91 5 71092 70 29503360
Chronic spontaneous urticaria 11.73 10.91 5 71092 71 29503359
Episcleritis 11.70 10.91 6 71091 132 29503298
Head banging 11.70 10.91 6 71091 132 29503298
Metastases to liver 11.68 10.91 7 71090 11849 29491581
Nervousness 11.67 10.91 56 71041 11250 29492180
Shock 11.64 10.91 21 71076 21383 29482047
Dysarthria 11.52 10.91 37 71060 30874 29472556
Occupational exposure to dust 11.50 10.91 3 71094 7 29503423
Actinic keratosis 11.46 10.91 27 71070 3759 29499671
Breech presentation 11.42 10.91 6 71091 139 29503291
Bronchial disorder 11.37 10.91 14 71083 1147 29502283
Duodenal ulcer 11.35 10.91 4 71093 9234 29494196
Ischaemic stroke 11.33 10.91 13 71084 15964 29487466
Sleep talking 11.29 10.91 9 71088 433 29502997
Painful respiration 11.24 10.91 14 71083 1160 29502270
Sinus bradycardia 11.22 10.91 7 71090 11596 29491834
Airway complication of anaesthesia 11.19 10.91 6 71091 145 29503285
Cerebral infarction 11.08 10.91 27 71070 24648 29478782
Neurodevelopmental disorder 11.07 10.91 8 71089 332 29503098
Sialadenosis 10.96 10.91 3 71094 9 29503421

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 5461.59 10.05 3474 193378 91751 64210129
Wheezing 2393.03 10.05 1975 194877 78604 64223276
Eosinophilic granulomatosis with polyangiitis 1734.14 10.05 550 196302 2332 64299548
Obstructive airways disorder 1207.50 10.05 798 196054 22387 64279493
Cough 941.02 10.05 2519 194333 299629 64002251
Forced expiratory volume decreased 833.51 10.05 411 196441 6456 64295424
Productive cough 796.93 10.05 1048 195804 72155 64229725
Dyspnoea 771.58 10.05 4259 192593 714415 63587465
Sputum discoloured 762.74 10.05 544 196308 17312 64284568
Full blood count abnormal 707.12 10.05 643 196209 29114 64272766
Toxicity to various agents 602.48 10.05 181 196671 363332 63938548
Chest discomfort 539.81 10.05 1133 195719 114973 64186907
Sleep disorder due to a general medical condition 491.70 10.05 309 196543 7925 64293955
Sleep terror 486.55 10.05 170 196682 1027 64300853
Nightmare 441.65 10.05 424 196428 20569 64281311
Nasal congestion 433.53 10.05 706 196146 58952 64242928
Urticaria 386.53 10.05 1156 195696 146161 64155719
Middle insomnia 375.95 10.05 313 196539 12564 64289316
Acute kidney injury 352.70 10.05 516 196336 448724 63853156
Suicidal ideation 317.96 10.05 657 196195 65885 64235995
Sinusitis 317.75 10.05 1074 195778 144854 64157026
Bronchitis 302.98 10.05 872 195980 107871 64194009
Blood immunoglobulin E increased 301.65 10.05 172 196680 3672 64298208
Aggression 297.12 10.05 518 196334 45714 64256166
Nasal polyps 291.83 10.05 165 196687 3464 64298416
Abnormal behaviour 288.99 10.05 430 196422 33192 64268688
Food allergy 287.41 10.05 218 196634 7633 64294247
Chronic obstructive pulmonary disease 269.97 10.05 640 196212 70408 64231472
Drug interaction 267.54 10.05 433 196419 361650 63940230
Therapeutic product effect incomplete 259.02 10.05 799 196053 102683 64199197
Neutropenia 256.27 10.05 213 196639 239411 64062469
Gastrooesophageal reflux disease 250.46 10.05 686 196166 82457 64219423
Anaemia 247.27 10.05 489 196363 378191 63923689
Completed suicide 245.55 10.05 195 196657 224219 64077661
Asthmatic crisis 236.87 10.05 113 196739 1643 64300237
Influenza 228.20 10.05 780 196072 105751 64196129
Upper respiratory tract infection 226.69 10.05 608 196244 72177 64229703
Off label use 224.28 10.05 1082 195770 631724 63670156
Anger 223.82 10.05 258 196594 15483 64286397
Anxiety 223.43 10.05 1213 195639 201436 64100444
Seasonal allergy 220.87 10.05 223 196629 11503 64290377
Febrile neutropenia 219.55 10.05 152 196700 187505 64114375
Thrombocytopenia 217.77 10.05 217 196635 223584 64078296
Drug abuse 216.92 10.05 67 196785 132307 64169573
Pancytopenia 213.46 10.05 85 196767 143224 64158656
Synovitis 207.99 10.05 28 196824 99062 64202818
Dyspnoea exertional 205.04 10.05 591 196261 73139 64228741
Infective pulmonary exacerbation of cystic fibrosis 201.74 10.05 213 196639 11583 64290297
Rhinitis allergic 200.57 10.05 179 196673 7899 64293981
Temperature regulation disorder 200.10 10.05 137 196715 4074 64297806
Breath sounds abnormal 200.09 10.05 211 196641 11458 64290422
Eosinophil count increased 193.46 10.05 227 196625 13885 64287995
Headache 182.74 10.05 2439 194413 527028 63774852
Sleep apnoea syndrome 181.00 10.05 326 196526 29506 64272374
Hypotension 178.82 10.05 582 196270 380392 63921488
Death 178.03 10.05 813 196039 481892 63819988
Malignant neoplasm progression 174.66 10.05 63 196789 112808 64189072
Rhinorrhoea 173.84 10.05 488 196364 59481 64242399
Loss of personal independence in daily activities 170.72 10.05 548 196304 71906 64229974
Eosinophilia 163.42 10.05 360 196492 37716 64264164
Pemphigus 162.28 10.05 5 196847 60696 64241184
Coeliac disease 162.13 10.05 153 196699 7259 64294621
Upper-airway cough syndrome 161.92 10.05 165 196687 8605 64293275
Nasopharyngitis 160.84 10.05 1087 195765 194986 64106894
Respiratory tract congestion 159.80 10.05 221 196631 15944 64285936
Hand deformity 158.26 10.05 8 196844 62763 64239117
Product quality issue 157.55 10.05 307 196545 29492 64272388
Bronchospasm 156.61 10.05 256 196596 21426 64280454
Anaphylactic reaction 155.16 10.05 512 196340 68152 64233728
Treatment failure 154.20 10.05 82 196770 116734 64185146
Mood altered 146.90 10.05 211 196641 15768 64286112
Pulmonary function test decreased 146.38 10.05 136 196716 6325 64295555
Rhinitis 145.63 10.05 172 196680 10593 64291287
Bronchial secretion retention 143.79 10.05 92 196760 2435 64299445
Hyponatraemia 142.88 10.05 145 196707 148194 64153686
Crying 142.13 10.05 235 196617 19855 64282025
Multiple organ dysfunction syndrome 141.67 10.05 66 196786 101347 64200533
Depression 140.20 10.05 999 195853 182292 64119588
Blood pressure systolic increased 133.22 10.05 392 196460 49061 64252819
Sensitivity to weather change 130.70 10.05 130 196722 6584 64295296
Heart rate increased 129.83 10.05 621 196231 98054 64203826
Polycystic ovaries 128.97 10.05 81 196771 2074 64299806
Pulmonary function test abnormal 127.32 10.05 93 196759 3071 64298809
Blood test abnormal 125.02 10.05 175 196677 12768 64289112
Drug intolerance 122.26 10.05 243 196609 187749 64114131
Pneumonia 118.85 10.05 2380 194472 557196 63744684
Joint swelling 118.46 10.05 305 196547 215077 64086803
Renal impairment 116.86 10.05 144 196708 134873 64167007
Secretion discharge 115.92 10.05 162 196690 11802 64290078
Sputum increased 115.85 10.05 93 196759 3542 64298338
Peak expiratory flow rate decreased 114.99 10.05 50 196802 578 64301302
Bronchial wall thickening 112.43 10.05 71 196781 1836 64300044
Oropharyngeal pain 111.68 10.05 552 196300 88315 64213565
Pericarditis 111.07 10.05 27 196825 62489 64239391
Respiratory rate increased 109.51 10.05 199 196653 18132 64283748
Perfume sensitivity 109.48 10.05 49 196803 610 64301270
Forced vital capacity decreased 108.76 10.05 64 196788 1452 64300428
Leukopenia 108.10 10.05 90 196762 101152 64200728
Disease progression 107.67 10.05 166 196686 141514 64160366
Hypersensitivity 106.94 10.05 991 195861 195461 64106419
Eczema 106.69 10.05 262 196590 29458 64272422
Bronchiectasis 106.26 10.05 170 196682 13970 64287910
Pruritus 105.72 10.05 1435 195417 310965 63990915
General physical health deterioration 105.25 10.05 299 196553 204126 64097754
Septic shock 105.05 10.05 100 196752 105337 64196543
Confusional state 104.51 10.05 426 196426 260718 64041162
Haemoglobin decreased 104.38 10.05 280 196572 194783 64107097
Sepsis 103.72 10.05 358 196494 229983 64071897
Respiratory tract infection 103.13 10.05 299 196553 37108 64264772
Bronchial obstruction 102.89 10.05 73 196779 2301 64299579
Irritability 102.54 10.05 295 196557 36451 64265429
Arthropathy 101.57 10.05 132 196720 120835 64181045
Contraindicated product administered 100.89 10.05 108 196744 107721 64194159
Product dose omission issue 100.81 10.05 972 195880 193775 64108105
Sneezing 100.71 10.05 173 196679 15078 64286802
Vital capacity decreased 100.68 10.05 54 196798 1018 64300862
Insomnia 99.76 10.05 982 195870 196854 64105026
Systemic lupus erythematosus 98.76 10.05 57 196795 77555 64224325
Dysphonia 98.70 10.05 339 196513 46043 64255837
Rhabdomyolysis 98.60 10.05 81 196771 91645 64210235
Intentional overdose 98.46 10.05 78 196774 89866 64212014
Infusion related reaction 98.23 10.05 223 196629 164244 64137636
Renal failure 97.05 10.05 261 196591 181427 64120453
Impaired quality of life 96.97 10.05 109 196743 6362 64295518
Stomatitis 96.85 10.05 115 196737 109490 64192390
Bone marrow failure 94.98 10.05 16 196836 47936 64253944
Platelet count decreased 94.90 10.05 234 196618 167477 64134403
Chronic sinusitis 94.31 10.05 106 196746 6186 64295694
Hyperkalaemia 93.82 10.05 102 196750 101027 64200853
Total lung capacity increased 93.79 10.05 45 196807 663 64301217
Sensitisation 93.52 10.05 61 196791 1670 64300210
Blood creatinine increased 93.08 10.05 170 196682 135612 64166268
Asthma-chronic obstructive pulmonary disease overlap syndrome 92.76 10.05 52 196800 1073 64300807
Dermatitis atopic 92.50 10.05 84 196768 3792 64298088
Lung hyperinflation 92.50 10.05 59 196793 1553 64300327
Coma 92.17 10.05 79 196773 87536 64214344
Glossodynia 92.07 10.05 41 196811 64655 64237225
Sinus congestion 91.46 10.05 167 196685 15272 64286608
Mood swings 89.95 10.05 178 196674 17290 64284590
Status asthmaticus 88.78 10.05 48 196804 920 64300960
Malaise 88.55 10.05 1699 195153 394548 63907332
Dust allergy 87.71 10.05 49 196803 1004 64300876
Blood pressure increased 87.21 10.05 857 195995 171695 64130185
Mucosal inflammation 86.98 10.05 41 196811 62543 64239337
Illness 86.96 10.05 201 196651 21737 64280143
Metabolic acidosis 86.25 10.05 55 196797 70903 64230977
Diarrhoea 86 10.05 1622 195230 721082 63580798
Aspirin-exacerbated respiratory disease 85.94 10.05 50 196802 1110 64300770
Eye pruritus 85.44 10.05 145 196707 12514 64289366
Throat clearing 84.39 10.05 52 196800 1286 64300594
Rales 84.30 10.05 160 196692 15069 64286811
Reversible airways obstruction 84.17 10.05 49 196803 1089 64300791
Immunodeficiency 83.87 10.05 165 196687 15959 64285921
Lower respiratory tract infection 83.83 10.05 535 196317 94079 64207801
Poor quality device used 83.05 10.05 60 196792 1947 64299933
Hypoventilation 82.96 10.05 97 196755 5909 64295971
Respiratory symptom 82.51 10.05 71 196781 2982 64298898
C-reactive protein increased 81.29 10.05 102 196750 94807 64207073
Cystic fibrosis 81.13 10.05 74 196778 3360 64298520
Bradycardia 81.04 10.05 148 196704 118071 64183809
Respiratory disorder 80.42 10.05 268 196584 35843 64266037
Cardiac arrest 80.26 10.05 224 196628 153840 64148040
Cardio-respiratory arrest 78.92 10.05 111 196741 98282 64203598
Restrictive pulmonary disease 78.81 10.05 60 196792 2112 64299768
Cardiac failure 78.61 10.05 180 196672 132193 64169687
Sinus disorder 78.42 10.05 165 196687 16743 64285137
Vocal cord dysfunction 78.35 10.05 34 196818 391 64301489
Bronchopulmonary aspergillosis allergic 77.61 10.05 53 196799 1569 64300311
Throat irritation 77.55 10.05 248 196604 32463 64269417
Sopor 77.33 10.05 3 196849 29658 64272222
Migraine 76.37 10.05 386 196466 62291 64239589
Helicobacter infection 75.54 10.05 13 196839 38349 64263531
Bronchial hyperreactivity 75.27 10.05 62 196790 2450 64299430
Therapeutic product effect decreased 75.04 10.05 149 196703 115202 64186678
Rhonchi 74.82 10.05 71 196781 3392 64298488
Smoke sensitivity 73.65 10.05 34 196818 457 64301423
Educational problem 73.44 10.05 32 196820 372 64301508
Dehydration 73.33 10.05 376 196476 216387 64085493
Abnormal dreams 71.72 10.05 120 196732 10236 64291644
Hypokalaemia 71.39 10.05 167 196685 121736 64180144
Respiration abnormal 71.09 10.05 92 196760 6223 64295657
Gastrointestinal haemorrhage 70.69 10.05 190 196662 132122 64169758
Neurotoxicity 70.67 10.05 3 196849 27401 64274479
Ascites 70.11 10.05 52 196800 61949 64239931
Multiple allergies 69.07 10.05 87 196765 5727 64296153
Sleep disorder 68.78 10.05 362 196490 59347 64242533
Intentional product use issue 68.42 10.05 116 196736 95248 64206632
Bursitis 68.38 10.05 181 196671 21304 64280576
Depressed level of consciousness 68.21 10.05 89 196763 81347 64220533
Right atrial hypertrophy 67.26 10.05 33 196819 512 64301368
Nasal discharge discolouration 67.07 10.05 50 196802 1704 64300176
Allergy to animal 65.21 10.05 40 196812 981 64300899
Ejection fraction 63.87 10.05 43 196809 1243 64300637
Eosinophilic pneumonia chronic 63.40 10.05 28 196824 337 64301543
Nasal oedema 63.13 10.05 39 196813 969 64300911
Impaired healing 63.02 10.05 55 196797 60418 64241462
Throat tightness 62.75 10.05 184 196668 22976 64278904
Rash erythematous 62.43 10.05 304 196548 48329 64253551
Feeling abnormal 62.41 10.05 653 196199 132949 64168931
Muscle injury 61.80 10.05 5 196847 26432 64275448
White blood cell count decreased 61.51 10.05 260 196592 157577 64144303
Dyspnoea at rest 60.27 10.05 85 196767 6244 64295636
C-reactive protein abnormal 59.08 10.05 9 196843 29038 64272842
Tic 59.08 10.05 55 196797 2564 64299316
Bronchial disorder 58.82 10.05 50 196802 2065 64299815
Anosmia 58.80 10.05 70 196782 4347 64297533
Obstruction 57.95 10.05 60 196792 3188 64298692
Nasal turbinate hypertrophy 56.92 10.05 30 196822 545 64301335
Encephalopathy 56.03 10.05 58 196794 58761 64243119
Depressed mood 56.01 10.05 261 196591 40751 64261129
Hepatic failure 55.79 10.05 52 196800 55342 64246538
Lactic acidosis 55.78 10.05 63 196789 61347 64240533
Idiopathic intracranial hypertension 55.71 10.05 53 196799 2540 64299340
Cytomegalovirus infection 55.45 10.05 22 196830 37177 64264703
Folliculitis 55.40 10.05 12 196840 30065 64271815
Neoplasm progression 55.15 10.05 28 196824 40936 64260944
Frustration tolerance decreased 55.01 10.05 80 196772 6045 64295835
Agranulocytosis 54.75 10.05 24 196828 38205 64263675
Acute myocardial infarction 54.57 10.05 80 196772 69638 64232242
Hepatocellular injury 53.70 10.05 36 196816 45199 64256681
Psychomotor hyperactivity 53.57 10.05 129 196723 14322 64287558
Nasal inflammation 52.76 10.05 29 196823 575 64301305
Alanine aminotransferase increased 52.35 10.05 232 196620 138799 64163081
Screaming 52.12 10.05 59 196793 3470 64298410
Decreased appetite 52.04 10.05 578 196274 280711 64021169
Dysplastic naevus 51.65 10.05 27 196825 482 64301398
Ear infection 51.49 10.05 173 196679 23231 64278649
Body temperature decreased 50.42 10.05 184 196668 25744 64276136
Wound 50.41 10.05 98 196754 76379 64225501
Hypoglycaemia 49.59 10.05 127 196725 89765 64212115
Hyper IgE syndrome 49.50 10.05 26 196826 469 64301411
Bronchial neoplasm 49.29 10.05 25 196827 418 64301462
Acute respiratory distress syndrome 48.95 10.05 29 196823 38906 64262974
Hepatotoxicity 48.52 10.05 31 196821 39931 64261949
Blood bilirubin increased 48.09 10.05 63 196789 57490 64244390
Neuroleptic malignant syndrome 48.06 10.05 9 196843 24987 64276893
International normalised ratio increased 47.51 10.05 107 196745 79060 64222820
Neutrophil count decreased 47.42 10.05 103 196749 77093 64224787
Serotonin syndrome 46.98 10.05 31 196821 39251 64262629
Prolonged expiration 46.92 10.05 30 196822 793 64301087
Sinusitis fungal 46.77 10.05 40 196812 1666 64300214
Total lung capacity decreased 46.44 10.05 40 196812 1682 64300198
Palmar-plantar erythrodysaesthesia syndrome 46.44 10.05 15 196837 28804 64273076
Stress 45.65 10.05 329 196523 60205 64241675
Neutropenic sepsis 45.57 10.05 8 196844 23264 64278616
Victim of child abuse 45.37 10.05 30 196822 841 64301039
Cholestasis 45.33 10.05 42 196810 44830 64257050
Delirium 45.32 10.05 89 196763 69105 64232775
Disseminated intravascular coagulation 45.24 10.05 21 196831 32327 64269553
Poor quality sleep 45.21 10.05 144 196708 18807 64283073
Acute myeloid leukaemia 44.78 10.05 14 196838 27449 64274431
Salpingo-oophorectomy unilateral 43.84 10.05 24 196828 472 64301408
Product substitution issue 43.78 10.05 137 196715 17724 64284156
Emphysema 43.23 10.05 117 196735 13952 64287928
Blood creatine phosphokinase increased 43.14 10.05 70 196782 58488 64243392
Humidity intolerance 42.91 10.05 21 196831 324 64301556
Mononeuropathy multiplex 42.79 10.05 21 196831 326 64301554
Swelling face 42.58 10.05 318 196534 58848 64243032
Solar lentigo 42.27 10.05 29 196823 865 64301015
Scratch 42.04 10.05 73 196779 6416 64295464
Myocardial infarction 41.83 10.05 315 196537 165506 64136374
Social avoidant behaviour 41.63 10.05 60 196792 4497 64297383
Lower respiratory tract congestion 41.20 10.05 48 196804 2913 64298967
Toxic epidermal necrolysis 40.95 10.05 32 196820 37134 64264746
Rhinitis perennial 40.88 10.05 18 196834 215 64301665
Mastocytosis 40.49 10.05 22 196830 426 64301454
Right ventricular hypertrophy 40.43 10.05 33 196819 1287 64300593
Melaena 40.40 10.05 63 196789 53485 64248395
Pleural effusion 40.28 10.05 224 196628 126335 64175545
Photodermatosis 40.01 10.05 28 196824 863 64301017
Aspartate aminotransferase increased 39.79 10.05 209 196643 119579 64182301
Sedation 39.35 10.05 41 196811 41421 64260459
Pneumonia aspiration 39.02 10.05 76 196776 59195 64242685
Drug resistance 38.96 10.05 30 196822 35072 64266808
Blood cholesterol 38.82 10.05 20 196832 346 64301534
Rash maculo-papular 38.75 10.05 52 196800 46974 64254906
Circulatory collapse 38.51 10.05 28 196824 33704 64268176
Sleep disorder due to general medical condition, insomnia type 38.40 10.05 16 196836 26254 64275626
Drug level increased 38.24 10.05 29 196823 34167 64267713
Skin plaque 37.75 10.05 84 196768 8856 64293024
Eosinophil count 37.61 10.05 14 196838 104 64301776
Alopecia 37.54 10.05 324 196528 165366 64136514
Viral infection 37.50 10.05 213 196639 35927 64265953
Interstitial lung disease 37.44 10.05 162 196690 97570 64204310
Nervousness 37.39 10.05 184 196668 29372 64272508
Suffocation feeling 37.34 10.05 34 196818 1540 64300340
Type 2 diabetes mellitus 36.96 10.05 203 196649 33817 64268063
Body tinea 36.85 10.05 31 196821 1262 64300618
Eye swelling 36.68 10.05 150 196702 22131 64279749
Anuria 36.10 10.05 7 196845 18957 64282923
Hypereosinophilic syndrome 36.02 10.05 21 196831 468 64301412
Metastases to bone 35.95 10.05 9 196843 20426 64281454
Metastases to liver 35.95 10.05 14 196838 23927 64277953
Aphonia 35.92 10.05 81 196771 8616 64293264
Separation anxiety disorder 35.79 10.05 10 196842 24 64301856
Cardiogenic shock 35.63 10.05 28 196824 32399 64269481
Nasal disorder 35.61 10.05 44 196808 2840 64299040
Endometrial ablation 35.57 10.05 25 196827 776 64301104
Eosinophilic bronchitis 35.53 10.05 19 196833 356 64301524
Personality change 35.46 10.05 80 196772 8513 64293367
Colitis 35.45 10.05 79 196773 58595 64243285
Affective disorder 35.03 10.05 68 196784 6512 64295368
Musculoskeletal stiffness 35.02 10.05 226 196626 122980 64178900
Therapy non-responder 34.90 10.05 95 196757 65804 64236076
Osteoporosis 34.84 10.05 234 196618 41846 64260034
Liver disorder 34.61 10.05 69 196783 53282 64248598
Haemodynamic instability 34.36 10.05 3 196849 14909 64286971
Hypomagnesaemia 34.32 10.05 38 196814 37338 64264542
Negative thoughts 34.30 10.05 30 196822 1288 64300592
Maternal exposure during pregnancy 34.30 10.05 163 196689 95721 64206159
Rheumatoid arthritis 34.29 10.05 328 196524 163966 64137914
Pneumocystis jirovecii pneumonia 34.15 10.05 21 196831 27613 64274267
Cerebral haemorrhage 34.07 10.05 65 196787 51025 64250855
Biliary dyskinesia 33.92 10.05 39 196813 2333 64299547
Increased viscosity of bronchial secretion 33.55 10.05 20 196832 465 64301415
Lipohypertrophy 33.51 10.05 24 196828 768 64301112
Nasal obstruction 33.51 10.05 30 196822 1329 64300551
Blood urea increased 33.26 10.05 52 196800 44101 64257779
Haemophagocytic lymphohistiocytosis 32.48 10.05 7 196845 17602 64284278
Weight decreased 32.46 10.05 1120 195732 284619 64017261
Hepatic function abnormal 32.37 10.05 95 196757 64218 64237662
Altered state of consciousness 32.17 10.05 41 196811 37861 64264019
Palpitations 32.03 10.05 472 196380 104016 64197864
Transplant rejection 31.93 10.05 7 196845 17394 64284486
Red blood cell sedimentation rate increased 31.83 10.05 29 196823 31206 64270674
Extrapyramidal disorder 31.82 10.05 10 196842 19542 64282338
Eosinophilic oesophagitis 31.75 10.05 19 196833 445 64301435
Ear discomfort 31.41 10.05 69 196783 7211 64294669
Cholecystitis chronic 31.36 10.05 80 196772 9207 64292673
Weight increased 31.07 10.05 862 195990 212486 64089394
Skin ulcer 31.06 10.05 54 196798 43920 64257960
Morbid thoughts 30.72 10.05 22 196830 704 64301176
Angioedema 30.68 10.05 306 196546 61515 64240365
Unresponsive to stimuli 30.32 10.05 68 196784 50325 64251555
Cognitive disorder 30.24 10.05 78 196774 55009 64246871
Mast cell activation syndrome 30.10 10.05 17 196835 356 64301524
Temperature intolerance 29.86 10.05 73 196779 8182 64293698
Hereditary angioedema 29.67 10.05 47 196805 3829 64298051
Atopy 29.67 10.05 15 196837 249 64301631
Fear 29.50 10.05 131 196721 20040 64281840
Sinus polyp 29.47 10.05 18 196834 438 64301442
Poisoning 29.38 10.05 15 196837 21864 64280016
Hyperbilirubinaemia 29.29 10.05 14 196838 21191 64280689
Lymphocyte count decreased 28.73 10.05 50 196802 40649 64261231
Lung diffusion test decreased 28.70 10.05 26 196826 1170 64300710
Overdose 28.64 10.05 330 196522 159236 64142644
Pulmonary mass 28.61 10.05 147 196705 23869 64278011
Diastolic dysfunction 28.48 10.05 75 196777 8800 64293080
Electrocardiogram QT prolonged 28.45 10.05 135 196717 79313 64222567
Panic attack 28.35 10.05 133 196719 20820 64281060
Increased bronchial secretion 28.30 10.05 39 196813 2803 64299077
Bronchial haemorrhage 28.22 10.05 26 196826 1196 64300684
Acute hepatic failure 28.12 10.05 23 196829 26089 64275791
Blood pressure fluctuation 28.05 10.05 74 196778 51797 64250083
Osteonecrosis of jaw 28.05 10.05 49 196803 39776 64262104
Infection susceptibility increased 28.04 10.05 38 196814 2688 64299192
Rheumatoid nodule 27.95 10.05 3 196849 12648 64289232
Nocturnal fear 27.81 10.05 7 196845 9 64301871
Fluid retention 27.65 10.05 291 196561 59315 64242565
Cerebral infarction 27.56 10.05 52 196800 40992 64260888
Hepatic encephalopathy 27.47 10.05 15 196837 21051 64280829
Heart sounds 27.20 10.05 19 196833 584 64301296
Nephropathy toxic 26.70 10.05 10 196842 17504 64284376
Total lung capacity abnormal 26.70 10.05 12 196840 151 64301729
Influenza like illness 26.66 10.05 297 196555 61405 64240475
Gamma-glutamyltransferase increased 26.39 10.05 69 196783 48441 64253439
Polyp 26.29 10.05 61 196791 6612 64295268
Self-injurious ideation 26.19 10.05 40 196812 3157 64298723
Respiratory arrest 26.14 10.05 79 196773 52906 64248974
Ischaemic stroke 26.13 10.05 30 196822 29005 64272875
Attention deficit hyperactivity disorder 26.08 10.05 37 196815 2733 64299147
Respiratory tract irritation 26.06 10.05 18 196834 543 64301337
Somnambulism 26 10.05 52 196800 5089 64296791
Neurosensory hypoacusis 25.97 10.05 13 196839 211 64301669
Erythema 25.89 10.05 751 196101 186319 64115561
Airway remodelling 25.81 10.05 12 196840 164 64301716
Swollen tongue 25.79 10.05 189 196663 34765 64267115
Accidental overdose 25.77 10.05 39 196813 33518 64268362
Renal tubular necrosis 25.70 10.05 18 196834 22092 64279788
FEV1/FVC ratio decreased 25.62 10.05 11 196841 123 64301757
Haemoptysis 25.42 10.05 245 196607 48803 64253077
Chronic spontaneous urticaria 25.41 10.05 17 196835 486 64301394
Blister 25.38 10.05 144 196708 80823 64221057
Vomiting 25.29 10.05 1400 195452 549717 63752163
Lacrimation increased 25.23 10.05 117 196735 18229 64283651
Drug reaction with eosinophilia and systemic symptoms 25.22 10.05 83 196769 54134 64247746
Intentional product misuse 25.21 10.05 124 196728 72171 64229709
Forced expiratory flow decreased 25.12 10.05 13 196839 227 64301653
Immune reconstitution inflammatory syndrome 25.05 10.05 4 196848 12466 64289414
Orthostatic hypotension 25.03 10.05 67 196785 46671 64255209
Cytopenia 25.02 10.05 8 196844 15463 64286417
Neuropathy peripheral 24.78 10.05 234 196618 117291 64184589
Burning sensation 24.72 10.05 246 196606 49418 64252462
Cortisol decreased 24.70 10.05 28 196824 1649 64300231
Haematemesis 24.70 10.05 68 196784 46931 64254949
Tubulointerstitial nephritis 24.64 10.05 35 196817 30874 64271006
Clostridium difficile colitis 24.64 10.05 28 196824 27195 64274685
Hypercalcaemia 24.63 10.05 36 196816 31380 64270500
Peritonitis 24.60 10.05 24 196828 24999 64276881
Diabetic ketoacidosis 24.59 10.05 33 196819 29812 64272068
Haematuria 24.54 10.05 98 196754 60373 64241507
Exposure to allergen 24.53 10.05 12 196840 185 64301695
Ejection fraction decreased 24.42 10.05 31 196821 28676 64273204
Pharyngeal swelling 24.34 10.05 53 196799 5506 64296374
Neurodevelopmental disorder 24.31 10.05 8 196844 39 64301841
Creatinine renal clearance decreased 24.15 10.05 7 196845 14414 64287466
Cardiac murmur 24.14 10.05 84 196768 11479 64290401
Hysterectomy 24.02 10.05 50 196802 5035 64296845
Haemodialysis 24.01 10.05 11 196841 17066 64284814
Eosinophilic pneumonia 24.00 10.05 47 196805 4530 64297350
Attention-seeking behaviour 23.76 10.05 10 196842 106 64301774
Progressive multifocal leukoencephalopathy 23.75 10.05 13 196839 18219 64283661
Sinus bradycardia 23.63 10.05 21 196831 22872 64279008
Proteinuria 23.51 10.05 30 196822 27693 64274187
Obsessive-compulsive disorder 23.49 10.05 48 196804 4770 64297110
Nasal discomfort 23.37 10.05 45 196807 4283 64297597
Stevens-Johnson syndrome 23.34 10.05 43 196809 34206 64267674
Spirometry abnormal 23.33 10.05 17 196835 559 64301321
Blebitis 23.30 10.05 6 196846 9 64301871
Enuresis 22.99 10.05 35 196817 2755 64299125
Homicidal ideation 22.90 10.05 38 196814 3219 64298661
Metastases to lung 22.79 10.05 9 196843 15255 64286625
Liver injury 22.78 10.05 35 196817 29897 64271983
Bone erosion 22.67 10.05 4 196848 11591 64290289
Allergy test positive 22.67 10.05 15 196837 421 64301459
Pharyngitis streptococcal 22.66 10.05 68 196784 8600 64293280
Atrioventricular block first degree 22.59 10.05 3 196849 10731 64291149
Lymphopenia 22.56 10.05 27 196825 25630 64276250
Hepatic enzyme increased 22.44 10.05 271 196581 129672 64172208
Nausea 22.24 10.05 2081 194771 783719 63518161
Status epilepticus 22.21 10.05 20 196832 21643 64280237
Pulmonary pain 22.12 10.05 33 196819 2551 64299329
Quality of life decreased 22.09 10.05 63 196789 7743 64294137
Suicidal behaviour 22.09 10.05 35 196817 2852 64299028
Snoring 22.07 10.05 46 196806 4636 64297244
Jaundice 22.06 10.05 75 196777 48437 64253443
Increased upper airway secretion 21.97 10.05 39 196813 3488 64298392
NPM1 gene mutation 21.96 10.05 10 196842 130 64301750
Bacteraemia 21.93 10.05 30 196822 26881 64274999
Infusion site pruritus 21.91 10.05 33 196819 2573 64299307
Shock haemorrhagic 21.83 10.05 12 196840 16779 64285101
Febrile bone marrow aplasia 21.75 10.05 4 196848 11251 64290629
Urinary retention 21.75 10.05 77 196775 49124 64252756
Cytokine release syndrome 21.63 10.05 19 196833 20810 64281070
Condition aggravated 21.59 10.05 923 195929 371503 63930377
Hypocalcaemia 21.50 10.05 61 196791 41692 64260188
Subarachnoid haemorrhage 21.45 10.05 15 196837 18423 64283457
Nephrectomy 21.39 10.05 24 196828 1398 64300482
Endocarditis fibroplastica 21.30 10.05 6 196846 15 64301865
Paraesthesia oral 21.30 10.05 88 196764 13043 64288837
Myelodysplastic syndrome 21.23 10.05 32 196820 27547 64274333
Miosis 21.21 10.05 7 196845 13259 64288621
Sinus operation 21.15 10.05 26 196826 1669 64300211
Haemorrhage intracranial 21.15 10.05 25 196827 23859 64278021
Hypoalbuminaemia 21.06 10.05 14 196838 17660 64284220
Pulmonary renal syndrome 21.02 10.05 16 196836 563 64301317
Abdominal discomfort 20.68 10.05 412 196440 181910 64119970
Upper limb fracture 20.58 10.05 95 196757 14771 64287109
Lactose intolerance 20.58 10.05 28 196824 1988 64299892
Skin necrosis 20.51 10.05 9 196843 14320 64287560
Torsade de pointes 20.36 10.05 14 196838 17349 64284531
Posterior reversible encephalopathy syndrome 20.34 10.05 24 196828 22922 64278958
Haematochezia 20.29 10.05 119 196733 66254 64235626
Asthenia 20.23 10.05 1084 195768 426960 63874920
Oropharyngeal discomfort 20.18 10.05 48 196804 5287 64296593
Appetite disorder 20.12 10.05 54 196798 6407 64295473
Female genital tract fistula 20.03 10.05 32 196820 2626 64299254
Inhibitory drug interaction 19.94 10.05 38 196814 3589 64298291
Urinary tract infection 19.94 10.05 546 196306 231050 64070830
Lip swelling 19.93 10.05 166 196686 31741 64270139
Blood alkaline phosphatase increased 19.93 10.05 96 196756 56183 64245697
Urticaria chronic 19.85 10.05 14 196838 437 64301443
Blood immunoglobulin G decreased 19.81 10.05 32 196820 2651 64299229
Electrolyte imbalance 19.71 10.05 29 196823 25214 64276666
Lung disorder 19.71 10.05 277 196575 60423 64241457
Carpal tunnel syndrome 19.64 10.05 98 196754 15730 64286150
Atrial fibrillation 19.59 10.05 386 196466 170703 64131177
Dysarthria 19.52 10.05 104 196748 59302 64242578
Mental disorder 19.51 10.05 143 196709 26302 64275578
Oxygen saturation decreased 19.42 10.05 446 196406 106730 64195150
Choking sensation 19.39 10.05 37 196815 3498 64298382
Ulcer 19.37 10.05 25 196827 22965 64278915
Neuropsychiatric symptoms 19.35 10.05 19 196833 947 64300933
Emotional disorder 19.29 10.05 83 196769 12524 64289356
Coagulopathy 19.26 10.05 43 196809 31877 64270003
Atrioventricular block complete 19.19 10.05 10 196842 14408 64287472
Thinking abnormal 19.18 10.05 78 196774 11478 64290402
Fall 19.07 10.05 1059 195793 415767 63886113
Injection site scab 19.05 10.05 12 196840 309 64301571
Epidural lipomatosis 18.98 10.05 18 196834 859 64301021
Hallucination 18.96 10.05 320 196532 72468 64229412
Syncope 18.85 10.05 353 196499 157282 64144598
Pigment dispersion syndrome 18.81 10.05 6 196846 26 64301854
Oesophageal polyp 18.80 10.05 7 196845 52 64301828
Eye disorder 18.78 10.05 110 196742 18759 64283121
Prescribed overdose 18.63 10.05 116 196736 20215 64281665
Respiratory tract inflammation 18.62 10.05 17 196835 773 64301107
Cytomegalovirus viraemia 18.61 10.05 5 196847 10823 64291057
Upper airway obstruction 18.52 10.05 21 196831 1237 64300643
Myoclonus 18.52 10.05 30 196822 25088 64276792
Ocular discomfort 18.51 10.05 39 196813 3960 64297920
Airway peak pressure increased 18.51 10.05 12 196840 325 64301555
Electrocardiogram QRS complex prolonged 18.49 10.05 3 196849 9241 64292639
Inflammation 18.44 10.05 120 196732 65180 64236700
Subdural haematoma 18.44 10.05 36 196816 28018 64273862
Venoocclusive liver disease 18.43 10.05 4 196848 10011 64291869
Infusion site swelling 18.37 10.05 47 196805 5418 64296462
Acute generalised exanthematous pustulosis 18.34 10.05 10 196842 14048 64287832
Eye paraesthesia 18.25 10.05 7 196845 57 64301823
Oliguria 18.12 10.05 11 196841 14565 64287315
Muscle rigidity 18.07 10.05 16 196836 17457 64284423
Gluten sensitivity 18.06 10.05 12 196840 339 64301541
Prothrombin time prolonged 18.05 10.05 13 196839 15728 64286152
Metastases to central nervous system 18.00 10.05 10 196842 13902 64287978
Sputum retention 17.97 10.05 18 196834 919 64300961
Liver function test abnormal 17.89 10.05 107 196745 59294 64242586
Pneumothorax spontaneous 17.78 10.05 19 196833 1047 64300833
Pharyngeal oedema 17.76 10.05 94 196758 15437 64286443
Pathogen resistance 17.76 10.05 8 196844 12535 64289345
Live birth 17.76 10.05 6 196846 11198 64290682
Lung hernia 17.74 10.05 7 196845 62 64301818
Incorrect dose administered 17.65 10.05 272 196580 60493 64241387
Tenosynovitis 17.63 10.05 7 196845 11826 64290054
Chronic kidney disease 17.62 10.05 104 196748 57815 64244065
Adrenal suppression 17.61 10.05 21 196831 1306 64300574
Acidosis 17.57 10.05 17 196835 17778 64284102
Tachycardia 17.57 10.05 336 196516 149243 64152637
Haemophilus infection 17.48 10.05 25 196827 1860 64300020
Ear pruritus 17.33 10.05 30 196822 2630 64299250
Sputum purulent 17.27 10.05 20 196832 1206 64300674
Blood lactic acid 17.26 10.05 13 196839 450 64301430
Panic reaction 17.19 10.05 38 196814 3989 64297891
Embolism venous 17.17 10.05 35 196817 3472 64298408
Intestinal perforation 17.10 10.05 13 196839 15300 64286580
Meningitis eosinophilic 17.09 10.05 5 196847 15 64301865
Pulmonary artery stenosis congenital 17.09 10.05 5 196847 15 64301865
Transaminases increased 17.02 10.05 74 196778 44520 64257360
Hyperkaliuria 16.95 10.05 9 196843 166 64301714
Hyposmia 16.89 10.05 14 196838 558 64301322
Glomerular filtration rate decreased 16.79 10.05 21 196831 19551 64282329
Pyrexia 16.69 10.05 1473 195379 557171 63744709
Functional residual capacity increased 16.65 10.05 7 196845 74 64301806
Brain oedema 16.62 10.05 26 196826 22049 64279831
Blood lactate dehydrogenase increased 16.54 10.05 49 196803 33029 64268851
CFTR gene mutation 16.49 10.05 7 196845 76 64301804
Fatigue 16.45 10.05 2563 194289 746167 63555713
Inappropriate schedule of product administration 16.40 10.05 383 196469 91903 64209977
Glucose tolerance impaired 16.33 10.05 50 196802 6393 64295487
Encephalitis 16.32 10.05 9 196843 12562 64289318
Injection site hypoaesthesia 16.30 10.05 12 196840 401 64301479
Gastrointestinal disorder 16.29 10.05 185 196667 89524 64212356
Toxic skin eruption 16.22 10.05 21 196831 19263 64282617
Chest pain 16.21 10.05 878 195974 235102 64066778
Chest X-ray abnormal 16.15 10.05 51 196801 6630 64295250
Shock 16.14 10.05 61 196791 38179 64263701
Respiratory failure 16.02 10.05 372 196480 160811 64141069
Nasal mucosal disorder 16.01 10.05 11 196841 329 64301551
Toxic encephalopathy 16.01 10.05 5 196847 9810 64292070
Bronchiolitis obliterans syndrome 15.99 10.05 10 196842 254 64301626
Pulmonary thrombosis 15.90 10.05 69 196783 10449 64291431
Emotional distress 15.81 10.05 174 196678 35864 64266016
Splenomegaly 15.69 10.05 19 196833 17942 64283938
Blood potassium increased 15.67 10.05 35 196817 25945 64275935
Cushingoid 15.67 10.05 55 196797 7548 64294332
Hepatitis C 15.64 10.05 7 196845 11008 64290872
Breast neoplasm 15.61 10.05 16 196836 840 64301040
Pulmonary oedema 15.59 10.05 159 196693 78515 64223365
Chimerism 15.58 10.05 10 196842 266 64301614
Poisoning deliberate 15.58 10.05 11 196841 13447 64288433
Ligament sprain 15.51 10.05 70 196782 10782 64291098
Ankle fracture 15.46 10.05 87 196765 14623 64287257
Intervertebral disc degeneration 15.41 10.05 80 196772 13040 64288840
Injection site pruritus 15.40 10.05 180 196672 37646 64264234
Infection 15.36 10.05 438 196414 184442 64117438
Fracture pain 15.33 10.05 11 196841 353 64301527
Mucosal discolouration 15.30 10.05 15 196837 746 64301134
Basal cell carcinoma 15.19 10.05 46 196806 30792 64271088
Forced expiratory volume abnormal 15.17 10.05 7 196845 94 64301786
Muscle tension dysphonia 15.16 10.05 4 196848 7 64301873
Dysphemia 15.12 10.05 31 196821 3088 64298792
Hallucination, auditory 15.12 10.05 96 196756 16843 64285037
Obesity 15.06 10.05 111 196741 20451 64281429
Anaphylactic shock 14.98 10.05 150 196702 30178 64271702
Upper gastrointestinal haemorrhage 14.98 10.05 56 196796 35164 64266716
Product taste abnormal 14.94 10.05 24 196828 1979 64299901
Allergic respiratory disease 14.93 10.05 6 196846 56 64301824
Endocarditis 14.90 10.05 5 196847 9373 64292507
Suspected suicide 14.86 10.05 4 196848 8650 64293230
Asthma exercise induced 14.85 10.05 7 196845 99 64301781
Allergic sinusitis 14.75 10.05 12 196840 466 64301414
Vasomotor rhinitis 14.74 10.05 6 196846 58 64301822
Ileus 14.64 10.05 30 196822 22936 64278944
Vasculitis 14.60 10.05 100 196752 17995 64283885
Sputum culture positive 14.58 10.05 30 196822 2996 64298884
Adenotonsillectomy 14.57 10.05 6 196846 60 64301820
Fibromyalgia 14.54 10.05 170 196682 35561 64266319
Benign prostatic hyperplasia 14.54 10.05 61 196791 9104 64292776
Hypohidrosis 14.52 10.05 9 196843 225 64301655
Schizophrenia 14.49 10.05 8 196844 11160 64290720
Eosinophil count abnormal 14.46 10.05 13 196839 579 64301301
Febrile convulsion 14.44 10.05 15 196837 800 64301080
Depressive symptom 14.43 10.05 38 196814 4458 64297422
Injection site urticaria 14.42 10.05 70 196782 11111 64290769
Crepitations 14.41 10.05 55 196797 7860 64294020
Chronic rhinosinusitis with nasal polyps 14.39 10.05 3 196849 0 64301880
Pigmentary glaucoma 14.39 10.05 3 196849 0 64301880
Sleep study abnormal 14.39 10.05 3 196849 0 64301880
Gastric haemorrhage 14.36 10.05 12 196840 13469 64288411
Pneumococcal infection 14.35 10.05 15 196837 806 64301074
Hyperglycaemia 14.34 10.05 118 196734 60850 64241030
Hemiparesis 14.33 10.05 45 196807 29782 64272098
Inappropriate antidiuretic hormone secretion 14.31 10.05 29 196823 22260 64279620
Irritable bowel syndrome 14.27 10.05 62 196790 37307 64264573
Ileus paralytic 14.25 10.05 4 196848 8411 64293469
Vocal cord disorder 14.24 10.05 19 196833 1324 64300556
Peak expiratory flow rate increased 14.20 10.05 4 196848 10 64301870
School refusal 14.20 10.05 5 196847 31 64301849
Laryngospasm 14.13 10.05 32 196820 3413 64298467
Catatonia 14.11 10.05 3 196849 7617 64294263
Enterococcal infection 13.98 10.05 13 196839 13853 64288027
Proctalgia 13.95 10.05 3 196849 7556 64294324
Pneumonia viral 13.95 10.05 54 196798 7768 64294112
Rectal haemorrhage 13.93 10.05 121 196731 61696 64240184
Klebsiella infection 13.93 10.05 12 196840 13269 64288611
Functional residual capacity decreased 13.90 10.05 6 196846 68 64301812
Abortion 13.90 10.05 18 196834 1218 64300662
Oesophagogastroduodenoscopy 13.90 10.05 8 196844 174 64301706
Paranasal sinus discomfort 13.72 10.05 30 196822 3125 64298755
Cardiac disorder 13.68 10.05 243 196609 55573 64246307
Panniculitis 13.65 10.05 5 196847 8874 64293006
Dialysis 13.65 10.05 19 196833 16901 64284979
Hypercapnia 13.63 10.05 53 196799 7641 64294239
Hospitalisation 13.63 10.05 313 196539 74894 64226986
Nasal septum deviation 13.58 10.05 20 196832 1528 64300352
Peripheral sensory neuropathy 13.58 10.05 9 196843 11369 64290511
Kidney transplant rejection 13.57 10.05 6 196846 9505 64292375
Tachypnoea 13.55 10.05 39 196813 26532 64275348
Expiratory reserve volume decreased 13.53 10.05 6 196846 73 64301807
Hand fracture 13.47 10.05 39 196813 4835 64297045
Growth retardation 13.46 10.05 20 196832 1541 64300339
Nodular vasculitis 13.45 10.05 5 196847 37 64301843
Blood calcium decreased 13.41 10.05 37 196815 25517 64276363
Gangrene 13.37 10.05 3 196849 7335 64294545
Bone density decreased 13.34 10.05 63 196789 9889 64291991
Hypertensive crisis 13.26 10.05 22 196830 18226 64283654
Drug-induced liver injury 13.22 10.05 88 196764 47555 64254325
Muscle spasticity 13.16 10.05 19 196833 16650 64285230
Therapeutic response unexpected 13.16 10.05 93 196759 16908 64284972
Acute sinusitis 13.16 10.05 35 196817 4131 64297749
Ataxia 13.12 10.05 30 196822 22054 64279826
Body temperature abnormal 13.10 10.05 20 196832 1578 64300302
Gallbladder disorder 13.09 10.05 93 196759 16937 64284943
Ligament pain 13.09 10.05 8 196844 195 64301685
Osteomyelitis 12.99 10.05 42 196810 27545 64274335
Contusion 12.98 10.05 447 196405 113518 64188362
Self esteem decreased 12.98 10.05 15 196837 902 64300978
Bronchopulmonary aspergillosis 12.97 10.05 24 196828 19061 64282819
Acute pulmonary oedema 12.92 10.05 12 196840 12797 64289083
Sinus pain 12.87 10.05 26 196826 2563 64299317
Delusion 12.83 10.05 22 196830 17992 64283888
Femur fracture 12.81 10.05 57 196795 34078 64267802
Product container issue 12.80 10.05 15 196837 916 64300964
Occupational exposure to dust 12.79 10.05 4 196848 16 64301864
Mandibular mass 12.77 10.05 8 196844 204 64301676
Nocturnal dyspnoea 12.74 10.05 18 196834 1324 64300556
Seizure 12.71 10.05 400 196452 166492 64135388
Infusion site erythema 12.71 10.05 48 196804 6825 64295055
Nasal pruritus 12.70 10.05 10 196842 370 64301510
Prostatomegaly 12.66 10.05 28 196824 2939 64298941
Onychophagia 12.65 10.05 6 196846 86 64301794
Serum ferritin increased 12.63 10.05 5 196847 8463 64293417
Lymphostasis 12.60 10.05 4 196848 17 64301863
Product appearance confusion 12.50 10.05 5 196847 46 64301834
Drug tolerance decreased 12.47 10.05 3 196849 6995 64294885
Frequent bowel movements 12.46 10.05 23 196829 18282 64283598
Cephalo-pelvic disproportion 12.42 10.05 7 196845 146 64301734
Leukoencephalopathy 12.39 10.05 3 196849 6964 64294916
Bronchitis chronic 12.38 10.05 33 196819 3899 64297981
Steroid diabetes 12.34 10.05 26 196826 2640 64299240
Lung opacity 12.34 10.05 29 196823 3170 64298710
Anticholinergic syndrome 12.32 10.05 26 196826 2643 64299237
Fight in school 12.32 10.05 3 196849 3 64301877
Allergy to fermented products 12.32 10.05 3 196849 3 64301877
Upper airway resistance syndrome 12.32 10.05 3 196849 3 64301877
Platelet adhesiveness decreased 12.32 10.05 3 196849 3 64301877
Haematocrit decreased 12.31 10.05 107 196745 54548 64247332
Gastric ulcer 12.27 10.05 49 196803 30185 64271695
Mite allergy 12.26 10.05 13 196839 710 64301170
Autophobia 12.24 10.05 4 196848 19 64301861
Cold agglutinins positive 12.23 10.05 5 196847 49 64301831
Measles 12.22 10.05 9 196843 301 64301579
Sputum abnormal 12.09 10.05 15 196837 972 64300908
Benign renal neoplasm 12.07 10.05 4 196848 20 64301860
Respiratory fume inhalation disorder 12.05 10.05 7 196845 155 64301725
Diverticulum oesophageal 12.05 10.05 7 196845 155 64301725
Gastroenteritis eosinophilic 12.04 10.05 8 196844 226 64301654
Aortic valve stenosis 12.04 10.05 36 196816 4544 64297336
Drug eruption 12.02 10.05 63 196789 36073 64265807
Cystic fibrosis respiratory infection suppression 12.01 10.05 10 196842 401 64301479
Miller Fisher syndrome 11.97 10.05 7 196845 157 64301723
Abnormal weight gain 11.94 10.05 23 196829 2190 64299690
Drug ineffective 11.89 10.05 2323 194529 837924 63463956
Cardiac tamponade 11.89 10.05 5 196847 8159 64293721
Body mass index increased 11.89 10.05 19 196833 1560 64300320
Aplastic anaemia 11.87 10.05 15 196837 13905 64287975
Duodenal ulcer 11.85 10.05 16 196836 14419 64287461
Unintentional medical device removal 11.78 10.05 3 196849 6731 64295149
Distal intestinal obstruction syndrome 11.77 10.05 12 196840 626 64301254
Lip discolouration 11.77 10.05 12 196840 626 64301254
Obsessive thoughts 11.74 10.05 15 196837 1002 64300878
Swelling 11.73 10.05 386 196466 159832 64142048
Myositis 11.67 10.05 20 196832 16357 64285523
Graft versus host disease 11.66 10.05 15 196837 13798 64288082
Hypernatraemia 11.63 10.05 12 196840 12177 64289703
Upper respiratory tract congestion 11.61 10.05 23 196829 2235 64299645
Tearfulness 11.60 10.05 36 196816 4637 64297243
Hyperammonaemia 11.59 10.05 8 196844 9896 64291984
Conjunctivitis allergic 11.58 10.05 15 196837 1015 64300865
Neurogenic shock 11.55 10.05 11 196841 528 64301352
Granulocytopenia 11.49 10.05 9 196843 10431 64291449
Gastroenteritis viral 11.46 10.05 101 196751 19628 64282252
Dyskinesia oesophageal 11.41 10.05 5 196847 59 64301821
Muscle spasms 11.38 10.05 533 196319 140490 64161390
Abdominal pain lower 11.32 10.05 42 196810 26427 64275453
Depression suicidal 11.30 10.05 24 196828 2451 64299429
Oral pruritus 11.30 10.05 20 196832 1785 64300095
Enterocolitis 11.27 10.05 12 196840 12006 64289874
Joint stiffness 11.27 10.05 51 196801 30353 64271527
Premature delivery 11.25 10.05 25 196827 18564 64283316
Otorrhoea 11.25 10.05 18 196834 1479 64300401
Stiff person syndrome 11.22 10.05 8 196844 254 64301626
Coronary artery disease 11.22 10.05 124 196728 60309 64241571
Faecaloma 11.20 10.05 8 196844 9720 64292160
Hip arthroplasty 11.14 10.05 31 196821 21320 64280560
Epstein-Barr virus infection 11.13 10.05 13 196839 12475 64289405
Graft versus host disease in lung 11.13 10.05 13 196839 791 64301089
Hypovolaemic shock 11.11 10.05 9 196843 10257 64291623
Laryngeal stenosis 11.09 10.05 13 196839 794 64301086
Small airways disease 11.07 10.05 4 196848 27 64301853
Psoriasis 11.07 10.05 292 196560 71411 64230469
Autism spectrum disorder 11.05 10.05 14 196838 927 64300953
Dermatitis acneiform 11.03 10.05 6 196846 8437 64293443
Hyperplastic cholecystopathy 11.01 10.05 6 196846 117 64301763
Hypothermia 10.99 10.05 28 196824 19828 64282052
Device related infection 10.98 10.05 52 196800 30574 64271306
Product contamination physical 10.96 10.05 6 196846 118 64301762
Hypovolaemia 10.95 10.05 19 196833 15467 64286413
Cardiac failure congestive 10.93 10.05 309 196543 130271 64171609
Product use in unapproved indication 10.93 10.05 651 196201 175967 64125913
Violence-related symptom 10.92 10.05 12 196840 683 64301197
Pertussis 10.91 10.05 13 196839 808 64301072
Bronchiolitis 10.91 10.05 30 196822 3611 64298269
Lower gastrointestinal haemorrhage 10.90 10.05 16 196836 13923 64287957
Choking 10.86 10.05 62 196790 10476 64291404
Squamous cell carcinoma of the oral cavity 10.83 10.05 10 196842 461 64301419
Decubitus ulcer 10.81 10.05 15 196837 13364 64288516
Refusal of treatment by patient 10.78 10.05 6 196846 8333 64293547
Mental status changes 10.76 10.05 127 196725 61035 64240845
Parkinsonism 10.75 10.05 17 196835 14356 64287524
Reaction to excipient 10.72 10.05 17 196835 1386 64300494
Paranoia 10.71 10.05 86 196766 16266 64285614
Blood albumin decreased 10.69 10.05 31 196821 21042 64280838
Flushing 10.66 10.05 315 196537 78333 64223547
Excessive eye blinking 10.66 10.05 16 196836 1244 64300636
Sarcoidosis 10.61 10.05 42 196810 6104 64295776
Bronchitis bacterial 10.59 10.05 16 196836 1251 64300629
Bradyphrenia 10.49 10.05 8 196844 9398 64292482
Hypervolaemia 10.48 10.05 71 196781 38214 64263666
Breast conserving surgery 10.48 10.05 11 196841 594 64301286
Animal scratch 10.46 10.05 14 196838 979 64300901
Hepatic cirrhosis 10.43 10.05 43 196809 26255 64275625
No adverse event 10.37 10.05 133 196719 28428 64273452
Enteritis 10.31 10.05 13 196839 12064 64289816
Prescribed underdose 10.28 10.05 25 196827 17990 64283890
Laryngitis fungal 10.28 10.05 6 196846 134 64301746
Cold urticaria 10.28 10.05 4 196848 34 64301846
Colitis ulcerative 10.20 10.05 36 196816 22992 64278888
Knee arthroplasty 10.18 10.05 45 196807 26954 64274926
Bacterial sepsis 10.18 10.05 5 196847 7452 64294428
Urosepsis 10.15 10.05 34 196818 22060 64279820
Joint range of motion decreased 10.15 10.05 28 196824 19315 64282565
Head banging 10.13 10.05 10 196842 502 64301378
Ventricular arrhythmia 10.08 10.05 5 196847 7410 64294470
BK virus infection 10.08 10.05 5 196847 7407 64294473

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DC03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
ATC R03DC53 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
FDA MoA N0000000083 Leukotriene Receptor Antagonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D065694 Cytochrome P-450 CYP1A2 Inducers
MeSH PA D006727 Hormone Antagonists
MeSH PA D020024 Leukotriene Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000175777 Leukotriene Receptor Antagonist
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:49159 leukotriene antagonists
CHEBI has role CHEBI:49167 anti-asthmatic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Non-allergic asthma indication 266361008 DOID:9360
Allergic asthma indication 389145006 DOID:9415
Asthma management indication 406162001
Exercise-Induced Bronchospasm Prevention indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Vasculitis of the skin contraindication 53312001
Dream disorder contraindication 85418005
Eosinophil count raised contraindication 386789004
Tremors contraindication
Nervousness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic
pKa2 4.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cysteinyl leukotriene receptor 1 GPCR ANTAGONIST Ki 9.30 CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.83 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.57 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.40 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.58 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.71 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.85 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 5.50 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.12 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.69 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 6.61 DRUG MATRIX
Cytochrome P450 2C8 Enzyme Ki 5.96 WOMBAT-PK
Delta-type opioid receptor GPCR Ki 5.77 DRUG MATRIX
Arachidonate 5-lipoxygenase Enzyme Ki 4.33 WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.33 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.82 DRUG MATRIX
Cysteinyl leukotriene receptor 2 GPCR Ki 5.30 PDSP
Mitogen-activated protein kinase 14 Kinase IC50 6.07 DRUG MATRIX
Substance-K receptor GPCR Ki 5.90 DRUG MATRIX
Uracil nucleotide/cysteinyl leukotriene receptor GPCR Ki 5.18 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.62 DRUG MATRIX
Cysteinyl leukotriene receptor 1 GPCR Ki 9.30 CHEMBL
Uracil nucleotide/cysteinyl leukotriene receptor GPCR ANTAGONIST IC50 7.21 IUPHAR

External reference:

IDSource
4024117 VUID
N0000022122 NUI
D00529 KEGG_DRUG
151767-02-1 SECONDARY_CAS_RN
4021110 VANDF
4024117 VANDF
C0298130 UMLSCUI
CHEBI:50730 CHEBI
MTK PDB_CHEM_ID
CHEMBL787 ChEMBL_ID
CHEMBL1200681 ChEMBL_ID
DB00471 DRUGBANK_ID
C093875 MESH_SUPPLEMENTAL_RECORD_UI
3340 IUPHAR_LIGAND_ID
7388 INN_ID
MHM278SD3E UNII
5281040 PUBCHEM_CID
115713 RXNORM
11578 MMSL
189710 MMSL
5134 MMSL
d04289 MMSL
007256 NDDF
007257 NDDF
108620002 SNOMEDCT_US
320883008 SNOMEDCT_US
373728005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7487 GRANULE 4 mg ORAL ANDA 31 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9649 TABLET, FILM COATED 10 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9650 TABLET, CHEWABLE 5 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9651 TABLET, CHEWABLE 4 mg ORAL ANDA 25 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5554 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5555 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5560 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0904-6808 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-079 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-079 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-080 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-080 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-081 TABLET 10 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-081 TABLET 10 mg ORAL ANDA 26 sections
MONTELUKAST SODIUM ORAL HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 19 sections
MONTELUKAST SODIUM ORAL HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 19 sections
MONTELUKAST SODIUM ORAL HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 19 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16729-119 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-221 TABLET, FILM COATED 10 mg ORAL NDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-565 TABLET, CHEWABLE 5 mg ORAL NDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-015 GRANULE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-016 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-017 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-018 TABLET, COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-220 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-221 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-222 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 31722-726 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-727 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-728 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections