monobenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1834	103-16-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

monobenzone
benoquin
benzoquin
hydroquinone benzyl ether
hydroquinone monobenzyl ether
leucodinine
monobenzon
monobenzyl ether hydroquinone
monobenzyl hydroquinone

Molecular weight: 200.24
Formula: C13H12O2
CLOGP: 3.34
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 29.46
ALOGS: -3.71
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 10, 1952	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D11AX13	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
FDA MoA	N0000175850	Melanin Synthesis Inhibitors
FDA PE	N0000175851	Depigmenting Activity
FDA EPC	N0000175853	Depigmenting Agent
CHEBI has role	CHEBI:50177	dermatologic agent
CHEBI has role	CHEBI:50904	alergeno
CHEBI has role	CHEBI:64933	melanin synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.05	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tyrosinase	Enzyme	P14679	TYRO_HUMAN	INHIBITOR				CHEMBL	CHEMBL
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	5.43		DRUG MATRIX
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	5.99		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.41		DRUG MATRIX
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.31		DRUG MATRIX

External reference:

ID	Source
4018885	VUID
N0000171571	NUI
D05072	KEGG_DRUG
4018885	VANDF
C0050962	UMLSCUI
CHEBI:34380	CHEBI
CHEMBL1388	ChEMBL_ID
DB00600	DRUGBANK_ID
7638	PUBCHEM_CID
588	INN_ID
C006429	MESH_SUPPLEMENTAL_RECORD_UI
6830	IUPHAR_LIGAND_ID
9L2KA76MG5	UNII
17145	RXNORM
133	MMSL
5133	MMSL
72832	MMSL
002020	NDDF
256167003	SNOMEDCT_US
414760009	SNOMEDCT_US

Pharmaceutical products:

None