monobenzone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1834 103-16-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • monobenzone
  • benoquin
  • benzoquin
  • hydroquinone benzyl ether
  • hydroquinone monobenzyl ether
  • leucodinine
  • monobenzon
  • monobenzyl ether hydroquinone
  • monobenzyl hydroquinone
  • Molecular weight: 200.24
  • Formula: C13H12O2
  • CLOGP: 3.34
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.46
  • ALOGS: -3.71
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 10, 1952 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX13 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
FDA PE N0000175851 Depigmenting Activity
FDA EPC N0000175853 Depigmenting Agent
FDA MoA N0000175850 Melanin Synthesis Inhibitors
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:64933 melanin synthesis inhibitor

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.05 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme INHIBITOR CHEMBL CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.43 DRUG MATRIX
Prostaglandin G/H synthase 1 Enzyme IC50 5.99 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.41 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.31 DRUG MATRIX

External reference:

IDSource
4018885 VUID
N0000171571 NUI
C0050962 UMLSCUI
D05072 KEGG_DRUG
256167003 SNOMEDCT_US
414760009 SNOMEDCT_US
72832 MMSL
17145 RXNORM
5133 MMSL
4018885 VANDF
002020 NDDF
9L2KA76MG5 UNII
588 INN_ID
7638 PUBCHEM_CID
CHEBI:34380 CHEBI
CHEMBL1388 ChEMBL_ID
DB00600 DRUGBANK_ID
C006429 MESH_SUPPLEMENTAL_RECORD_UI
6830 IUPHAR_LIGAND_ID

Pharmaceutical products:

None