mofezolac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory agents, ibufenac derivatives | 1829 | 78967-07-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Cyclooxygenase 1 inhibitor; ; RN from Toxlit
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | PMDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.86 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.36 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.85 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.85 | CHEMBL | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.36 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01718 | KEGG_DRUG |
| C0043597 | UMLSCUI |
| CHEBI:31860 | CHEBI |
| 63X | PDB_CHEM_ID |
| CHEMBL259972 | ChEMBL_ID |
| C054999 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4237 | PUBCHEM_CID |
| 6701 | INN_ID |
| RVJ0BV3H3Y | UNII |
| 11469 | RXNORM |
| 008241 | NDDF |
Pharmaceutical products:
None