mitiglinide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihyperglycaemics	1818	145375-43-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mitiglinide
mitiglinide calcium
mitiglinide calcium hydrate
S 21403
KAD-1229

a rapid and short-acting hypoglycemic agent; acts on sulfonylurea receptor closing KATP channels; considered one of the glinides-an imprecise grouping; structure given in first source

Molecular weight: 315.41
Formula: C19H25NO3
CLOGP: 3.06
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 57.61
ALOGS: -3.65
ROTB: 5

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.07 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 22, 2011	PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Renal impairment	50.35	37.82	27	812	157756	79585793
Hypoglycaemia	39.87	37.82	20	819	101574	79641975
Altered state of consciousness	37.82	37.82	15	824	43807	79699742

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10BX08	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Other blood glucose lowering drugs, excl. insulins
MeSH PA	D007004	Hypoglycemic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.91	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sulfonylurea receptor 1, Kir6.2	Ion channel	Q09428 Q14654	ABCC8_HUMAN KCJ11_HUMAN	BLOCKER	IC50	7		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D01854	KEGG_DRUG
C0906166	UMLSCUI
CHEBI:31740	CHEBI
9I0	PDB_CHEM_ID
CHEMBL471498	ChEMBL_ID
DB01252	DRUGBANK_ID
C087255	MESH_SUPPLEMENTAL_RECORD_UI
121891	PUBCHEM_CID
7710	INN_ID
D86I0XLB13	UNII
CHEMBL4298005	ChEMBL_ID

Pharmaceutical products:

None